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Conserved domains on  [gi|1720421568|ref|XP_030098174|]
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zinc finger protein 710 isoform X2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
337-595 4.85e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 4.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 337 PSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFA--YPSELKAHEVKHESgrCHVCVEC 414
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksLLSQSPSSLSSSDS--SSSASES 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 415 -----GLDFSTLTQLKRHL-ASHQGPTL-YQCLECDKSFHYRSQLQNHMLKH----QNVRPFVCTE--CGMEFSQIHHLK 481
Cdd:COG5048   261 prsslPTASSQSSSPNESDsSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCPYslCGKLFSRNDALK 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 482 QHSLTHKGVKEFKC--EVCGREFTLQANMKRHMLIHTSV-----RPYQC--HICFKTFVQKQTLKTHMIVHSPVKP--FK 550
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKdlkndKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1720421568 551 CKVCGKSFNRMYNLLGHMHLHAGSKPFkCPYCSSKFNLKGNLSRH 595
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
337-595 4.85e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 4.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 337 PSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFA--YPSELKAHEVKHESgrCHVCVEC 414
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksLLSQSPSSLSSSDS--SSSASES 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 415 -----GLDFSTLTQLKRHL-ASHQGPTL-YQCLECDKSFHYRSQLQNHMLKH----QNVRPFVCTE--CGMEFSQIHHLK 481
Cdd:COG5048   261 prsslPTASSQSSSPNESDsSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCPYslCGKLFSRNDALK 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 482 QHSLTHKGVKEFKC--EVCGREFTLQANMKRHMLIHTSV-----RPYQC--HICFKTFVQKQTLKTHMIVHSPVKP--FK 550
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKdlkndKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1720421568 551 CKVCGKSFNRMYNLLGHMHLHAGSKPFkCPYCSSKFNLKGNLSRH 595
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
536-560 3.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.37e-04
                          10        20
                  ....*....|....*....|....*
gi 1720421568 536 LKTHMIVHSPVKPFKCKVCGKSFNR 560
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
 425-512 5.96e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 5.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 425 KRHLASHQGPTLYQCLECDKSFH------------------YRSQLQNH------MLKHQNVRPFVCTECGMEFSQIHHL 480
Cdd:PHA00733   10 KKYLSNHKGIFIHVTLEELKRYHsltpeqkrliravvktliYNPQLLDEssylykLLTSKAVSPYVCPLCLMPFSSSVSL 89

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720421568 481 KQHSLTHKGVKefKCEVCGREFTLQANMKRHM 512
Cdd:PHA00733   90 KQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
337-595 4.85e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 4.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 337 PSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEVKPYSCHFCGRGFA--YPSELKAHEVKHESgrCHVCVEC 414
Cdd:COG5048   183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPksLLSQSPSSLSSSDS--SSSASES 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 415 -----GLDFSTLTQLKRHL-ASHQGPTL-YQCLECDKSFHYRSQLQNHMLKH----QNVRPFVCTE--CGMEFSQIHHLK 481
Cdd:COG5048   261 prsslPTASSQSSSPNESDsSSEKGFSLpIKSKQCNISFSRSSPLTRHLRSVnhsgESLKPFSCPYslCGKLFSRNDALK 340

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 482 QHSLTHKGVKEFKC--EVCGREFTLQANMKRHMLIHTSV-----RPYQC--HICFKTFVQKQTLKTHMIVHSPVKP--FK 550
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKdlkndKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1720421568 551 CKVCGKSFNRMYNLLGHMHLHAGSKPFkCPYCSSKFNLKGNLSRH 595
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
427-597 3.79e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 3.79e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 427 HLASHQGPTLYQCLECDKSFHYRSQLQNHMLKHQNVR-PFVCTECGMEFSQIHHLKQH----SLTHKGVKEFKC--EVCG 499
Cdd:COG5048   251 SDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHlrsvNHSGESLKPFSCpySLCG 330

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 500 REFTLQANMKRHMLIHTSVRPYQCHIC--------------FKTFVQKQTLKtHMIVHSPVKPFKCKVCGKSFNRMYNLl 565
Cdd:COG5048   331 KLFSRNDALKRHILLHTSISPAKEKLLnssskfspllnnepPQSLQQYKDLK-NDKKSETLSNSCIRNFKRDSNLSLHI- 408

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1720421568 566 gHMHLHAGSKPFKCPYCSSKFNLKGNLSRHMK 597
Cdd:COG5048   409 -ITHLSFRPYNCKNPPCSKSFNRHYNLIPHKK 439
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
302-591 4.84e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 4.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 302 CEKSYTSKYNLVTHILGHNGIKPHSCPH--CSKLFKQPSHLQTHLLTHQGTRPHKC-QVCHKAFTQTSHLKRHMLLHSEV 378
Cdd:COG5048    39 CTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLSSSSSNSN 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 379 KPYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLD-------FSTLTQLKRHLASHQGPTLYQCLEC-DKSFHYRS 450
Cdd:COG5048   119 DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSsvntpqsNSLHPPLPANSLSKDPSSNLSLLISsNVSTSIPS 198

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 451 QLQNHMLKHQNVRPFVCTECGMEFSQIH--------HLKQHSLTHKGVKEFK------CEVCGREFTLQANMKRHMLIHT 516
Cdd:COG5048   199 SSENSPLSSSYSIPSSSSDQNLENSSSSlplttnsqLSPKSLLSQSPSSLSSsdssssASESPRSSLPTASSQSSSPNES 278

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 517 SVR-------PYQCHICFKTFVQKQTLKTHM--IVHS--PVKPFKCKV--CGKSFNRMYNLLGHMHLHAGSKPFKCPY-- 581
Cdd:COG5048   279 DSSsekgfslPIKSKQCNISFSRSSPLTRHLrsVNHSgeSLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLln 358

                         330
                  ....*....|
gi 1720421568 582 CSSKFNLKGN 591
Cdd:COG5048   359 SSSKFSPLLN 368
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
305-539 7.67e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 7.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 305 SYTSKYNLVTHILGHNGIKPHSCPHCSKLFKQPSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEV------ 378
Cdd:COG5048   207 SSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgf 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 379 -KPYSCHFCGRGFAYPSELKAH--EVKH--ESGRCHVCVE--CGLDFSTLTQLKRHLASHQGPTLYQCLECD-------K 444
Cdd:COG5048   287 sLPIKSKQCNISFSRSSPLTRHlrSVNHsgESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspL 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 445 SFHYRSQLQNHMLKHQNVRPFVCT--ECGMEFSQIHHLKQHSLTHKGVK--EFKCEVCGREFTLQANMKRHMLIHTSVRP 520
Cdd:COG5048   367 LNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                         250
                  ....*....|....*....
gi 1720421568 521 YQCHICFKtFVQKQTLKTH 539
Cdd:COG5048   447 LLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
536-560 3.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.37e-04
                          10        20
                  ....*....|....*....|....*
gi 1720421568 536 LKTHMIVHSPVKPFKCKVCGKSFNR 560
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
339-364 6.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.37e-04
                          10        20
                  ....*....|....*....|....*.
gi 1720421568 339 HLQTHLLTHQGTRPHKCQVCHKAFTQ 364
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
367-392 2.07e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720421568 367 HLKRHMLLHSEVKPYSCHFCGRGFAY 392
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 353-375 2.10e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|...
gi 1720421568 353 HKCQVCHKAFTQTSHLKRHMLLH 375
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 349-403 2.96e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.96e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720421568 349 GTRPHKCQV--CHKAFTQTSHLKRHML-------------------LHSEVKPYSCHFCGRGFAYPSELKAHeVKH 403
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYH-RKH 420
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 437-459 5.78e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.78e-03
                          10        20
                  ....*....|....*....|...
gi 1720421568 437 YQCLECDKSFHYRSQLQNHMLKH 459
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 425-512 5.96e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 5.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720421568 425 KRHLASHQGPTLYQCLECDKSFH------------------YRSQLQNH------MLKHQNVRPFVCTECGMEFSQIHHL 480
Cdd:PHA00733   10 KKYLSNHKGIFIHVTLEELKRYHsltpeqkrliravvktliYNPQLLDEssylykLLTSKAVSPYVCPLCLMPFSSSVSL 89

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720421568 481 KQHSLTHKGVKefKCEVCGREFTLQANMKRHM 512
Cdd:PHA00733   90 KQHIRYTEHSK--VCPVCGKEFRNTDSTLDHV 119
zf-H2C2_2 pfam13465
Zinc-finger double domain;
507-532 6.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 1720421568 507 NMKRHMLIHTSVRPYQCHICFKTFVQ 532
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 521-543 6.25e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.25e-03
                          10        20
                  ....*....|....*....|...
gi 1720421568 521 YQCHICFKTFVQKQTLKTHMIVH 543
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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