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Conserved domains on  [gi|1720423867|ref|XP_030098779|]
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trafficking protein particle complex subunit 6A isoform X1 [Mus musculus]

Protein Classification

trafficking protein particle complex subunit( domain architecture ID 10202223)

trafficking protein particle complex subunit is a component of TRAPP (transport protein particle) tethering complexes that have an important role at the different steps of vesicle transport

CATH:  3.30.1380.20
Gene Ontology:  GO:0006888|GO:0030008
PubMed:  9564032|27066478|18801063|22669257|20966969

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAPPC6A_Trs33 cd14944
Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking ...
 3-129 2.80e-52

Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking protein particle complex (TRAPP). TRS33 is one of the six core subunits of TRAPP complexes which play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane. In mammals, mutations in TRAPPC6a cause mosaic loss of coat pigment.


:

Pssm-ID: 271347  Cd Length: 167  Bit Score: 162.42  E-value: 2.80e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423867   3 DAVLFEFLHTEMVAELWAPDPDP---------GSGGKRRSLSVLEGLGFRVGQALGERLPLETPAFREELDALKFLCRDL 73
Cdd:cd14944     1 SESLFDFLLIEMVPYLLASASELkeseelddaEEEDDEAVLSRLEAIGFRVGLRLAERLTKDRPRFSDPLDVIKFICKDF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423867  74 WAAMFQKHMDGLRTNHQ-------------------------------FLAFTCGLLCGALHTLGFQSLVTASVASLPAC 122
Cdd:cd14944    81 WTAVFGKQIDNLRTNHRgvyvlqdnsfrwlsrlssgdgaaqsleeappYLAFPCGIIRGALANLGIPSTVTAEVTSLPGC 160


                  ....*..
gi 1720423867 123 KFQVVIQ 129
Cdd:cd14944   161 TFQIRIQ 167
 
Name Accession Description Interval E-value
TRAPPC6A_Trs33 cd14944
Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking ...
 3-129 2.80e-52

Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking protein particle complex (TRAPP). TRS33 is one of the six core subunits of TRAPP complexes which play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane. In mammals, mutations in TRAPPC6a cause mosaic loss of coat pigment.


Pssm-ID: 271347  Cd Length: 167  Bit Score: 162.42  E-value: 2.80e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423867   3 DAVLFEFLHTEMVAELWAPDPDP---------GSGGKRRSLSVLEGLGFRVGQALGERLPLETPAFREELDALKFLCRDL 73
Cdd:cd14944     1 SESLFDFLLIEMVPYLLASASELkeseelddaEEEDDEAVLSRLEAIGFRVGLRLAERLTKDRPRFSDPLDVIKFICKDF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423867  74 WAAMFQKHMDGLRTNHQ-------------------------------FLAFTCGLLCGALHTLGFQSLVTASVASLPAC 122
Cdd:cd14944    81 WTAVFGKQIDNLRTNHRgvyvlqdnsfrwlsrlssgdgaaqsleeappYLAFPCGIIRGALANLGIPSTVTAEVTSLPGC 160


                  ....*..
gi 1720423867 123 KFQVVIQ 129
Cdd:cd14944   161 TFQIRIQ 167
TRAPP pfam04051
Transport protein particle (TRAPP) component; TRAPP plays a key role in the targeting and/or ...
 7-126 3.13e-26

Transport protein particle (TRAPP) component; TRAPP plays a key role in the targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment. TRAPP is a large multimeric protein that contains at least 10 subunits. This family contains many TRAPP family proteins. The Bet3 subunit is one of the better characterized TRAPP proteins and has a dimeric structure with hydrophobic channels. The channel entrances are located on a putative membrane-interacting surface that is distinctively flat, wide and decorated with positively charged residues. Bet3 is proposed to localize TRAPP to the Golgi.


Pssm-ID: 461147  Cd Length: 148  Bit Score: 95.62  E-value: 3.13e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423867   7 FEFLHTEMVAELWAPDPDPGSGGKRrslsvLEGLGFRVGQALGERLPL--ETPAFREELDALKFLCRDLWAAMFQKHMDG 84
Cdd:pfam04051   1 FALLYGELVAYLQKDSEDVEEVNKR-----LEKMGYNIGQRLIELFLArdSRCRFTDFLETLKFICKDVWKMLFGKQADN 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720423867  85 LRTNHQ--------------------------FLAFTCGLLCGALHTLGFQSLVTA----SVASLPACKFQV 126
Cdd:pfam04051  76 LETNHDgeyvlidneppltrfvelpkdgsqlnYLAFLCGIIRGALEMLGFPARVTAhfvpSDVLRGDTTFEI 147
 
Name Accession Description Interval E-value
TRAPPC6A_Trs33 cd14944
Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking ...
 3-129 2.80e-52

Trs33 subunit of the TRAPP complex; TRS33 (also known as TRAPPC6A) subunit of the trafficking protein particle complex (TRAPP). TRS33 is one of the six core subunits of TRAPP complexes which play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane. In mammals, mutations in TRAPPC6a cause mosaic loss of coat pigment.


Pssm-ID: 271347  Cd Length: 167  Bit Score: 162.42  E-value: 2.80e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423867   3 DAVLFEFLHTEMVAELWAPDPDP---------GSGGKRRSLSVLEGLGFRVGQALGERLPLETPAFREELDALKFLCRDL 73
Cdd:cd14944     1 SESLFDFLLIEMVPYLLASASELkeseelddaEEEDDEAVLSRLEAIGFRVGLRLAERLTKDRPRFSDPLDVIKFICKDF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423867  74 WAAMFQKHMDGLRTNHQ-------------------------------FLAFTCGLLCGALHTLGFQSLVTASVASLPAC 122
Cdd:cd14944    81 WTAVFGKQIDNLRTNHRgvyvlqdnsfrwlsrlssgdgaaqsleeappYLAFPCGIIRGALANLGIPSTVTAEVTSLPGC 160


                  ....*..
gi 1720423867 123 KFQVVIQ 129
Cdd:cd14944   161 TFQIRIQ 167
TRAPP pfam04051
Transport protein particle (TRAPP) component; TRAPP plays a key role in the targeting and/or ...
 7-126 3.13e-26

Transport protein particle (TRAPP) component; TRAPP plays a key role in the targeting and/or fusion of ER-to-Golgi transport vesicles with their acceptor compartment. TRAPP is a large multimeric protein that contains at least 10 subunits. This family contains many TRAPP family proteins. The Bet3 subunit is one of the better characterized TRAPP proteins and has a dimeric structure with hydrophobic channels. The channel entrances are located on a putative membrane-interacting surface that is distinctively flat, wide and decorated with positively charged residues. Bet3 is proposed to localize TRAPP to the Golgi.


Pssm-ID: 461147  Cd Length: 148  Bit Score: 95.62  E-value: 3.13e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423867   7 FEFLHTEMVAELWAPDPDPGSGGKRrslsvLEGLGFRVGQALGERLPL--ETPAFREELDALKFLCRDLWAAMFQKHMDG 84
Cdd:pfam04051   1 FALLYGELVAYLQKDSEDVEEVNKR-----LEKMGYNIGQRLIELFLArdSRCRFTDFLETLKFICKDVWKMLFGKQADN 75

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720423867  85 LRTNHQ--------------------------FLAFTCGLLCGALHTLGFQSLVTA----SVASLPACKFQV 126
Cdd:pfam04051  76 LETNHDgeyvlidneppltrfvelpkdgsqlnYLAFLCGIIRGALEMLGFPARVTAhfvpSDVLRGDTTFEI 147
TRAPPC_bet3-like cd14941
Bet3-like domains of TRAPP; Bet3-like domains of a subfamily of core components of the ...
 6-126 1.23e-16

Bet3-like domains of TRAPP; Bet3-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP) include TRAPPC3, TRAPPC5, and TRAPPC6A. TRAPP complexes play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane. TRAPPs are large multimeric protein complexes which contain six core subunits that belong to two distinct structural families, the bet3-like family and the sedlin-like family.


Pssm-ID: 271344  Cd Length: 152  Bit Score: 71.34  E-value: 1.23e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423867   6 LFEFLHTEMVAELWAPDPDPGSGGKRrslsvLEGLGFRVGQALGERLPLET--PAFREELDALKFLCRDLWAAMFQKHMD 83
Cdd:cd14941     4 LFALLFGEMVSQLCKDYESVGDVNTK-----LADMGFNIGARLIEDFLARKngKRCTKVLDILLFIKKNAWKALFGKTPD 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720423867  84 GLRTNHQ---------------------------FLAFTCGLLCGALHTLGFQSLVTASVASL---PACKFQV 126
Cdd:cd14941    79 ILNWSHDddtyslidnepplndfislpdensslnYSAFTCGIIRGILENVGFPCKVTAHWDKLggdPGTEIMI 151
TRAPPC5_Trs31 cd14943
Trs31 subunit of the TRAPP complex; TRS31 (also known as TRAPPC5) subunit of the trafficking ...
 7-114 4.78e-05

Trs31 subunit of the TRAPP complex; TRS31 (also known as TRAPPC5) subunit of the trafficking protein particle complex (TRAPP). TRS31 is one of the six core subunits of TRAPP complexes which play a key role in the regulation of ER-to-Golgi and intra-Golgi transport by tethering the vesicle membrane to the target membrane.


Pssm-ID: 271346  Cd Length: 158  Bit Score: 40.60  E-value: 4.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720423867   7 FEFLHTEMVAELwapdpdpgsggKRRSLSV------LEGLGFRVGQALGERLPLETPAFREE---LDALKFLCRDLWAAM 77
Cdd:cd14943     6 FAFLFSEMVQYA-----------QRRVKSIseleqrLSELGYRVGIRLLELLSLREKGPKREtriLSILQFIKTTVWKYL 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720423867  78 FQKHMDGLR-----------TNHQFL-----------------AFTCGLLCGALHTLGFQSLVTA 114
Cdd:cd14943    75 FGKEADSLEkstdddneymiIDNEPLvnkfisvpkdmgglncaAFVAGIIEGVLDSAGFPAKVTA 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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