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Conserved domains on  [gi|1720427389|ref|XP_030099400|]
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WD repeat-containing protein 17 isoform X3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
333-658 3.94e-62

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.94e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  333 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 412
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  413 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 490
Cdd:COG2319    163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  491 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 568
Cdd:COG2319    239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  569 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 646
Cdd:COG2319    314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                          330
                   ....*....|..
gi 1720427389  647 CSRDSTVRLWSL 658
Cdd:COG2319    390 GSADGTVRLWDL 401
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-441 1.27e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 1.27e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389   51 LHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWNVAEQKVIAKLdniKETPACLGWCwnthdavAFVSQKGPLLIw 130
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTL---KGHTGPVRDV-------AASADGTYLAS- 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  131 tiSGPDSgvsvhkeahsfasDICIFRWHTQKKGKVAFGHidgsisifqpgsknqkhvlrpdslegtdeEDPVTALEWDPl 210
Cdd:cd00200     69 --GSSDK-------------TIRLWDLETGECVRTLTGH-----------------------------TSYVSSVAFSP- 103

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  211 STDYLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktg 290
Cdd:cd00200    104 DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVN--SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLT----- 174

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  291 fhcFHV--VNSppkkkfSVQSPNKNHYISSTSeavpppnltqnqafslppghvvccflDGGVGLYDMGAKKWdfLREL-G 367
Cdd:cd00200    175 ---GHTgeVNS------VAFSPDGEKLLSSSS--------------------------DGTIKLWDLSTGKC--LGTLrG 217

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720427389  368 HVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWD 441
Cdd:cd00200    218 HENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
333-658 3.94e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.94e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  333 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 412
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  413 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 490
Cdd:COG2319    163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  491 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 568
Cdd:COG2319    239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  569 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 646
Cdd:COG2319    314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                          330
                   ....*....|..
gi 1720427389  647 CSRDSTVRLWSL 658
Cdd:COG2319    390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 367-657 3.33e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 3.33e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  367 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 446
Cdd:cd00200      7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  447 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 524
Cdd:cd00200     85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  525 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 604
Cdd:cd00200    162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720427389  605 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 657
Cdd:cd00200    238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-441 1.27e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 1.27e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389   51 LHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWNVAEQKVIAKLdniKETPACLGWCwnthdavAFVSQKGPLLIw 130
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTL---KGHTGPVRDV-------AASADGTYLAS- 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  131 tiSGPDSgvsvhkeahsfasDICIFRWHTQKKGKVAFGHidgsisifqpgsknqkhvlrpdslegtdeEDPVTALEWDPl 210
Cdd:cd00200     69 --GSSDK-------------TIRLWDLETGECVRTLTGH-----------------------------TSYVSSVAFSP- 103

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  211 STDYLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktg 290
Cdd:cd00200    104 DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVN--SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLT----- 174

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  291 fhcFHV--VNSppkkkfSVQSPNKNHYISSTSeavpppnltqnqafslppghvvccflDGGVGLYDMGAKKWdfLREL-G 367
Cdd:cd00200    175 ---GHTgeVNS------VAFSPDGEKLLSSSS--------------------------DGTIKLWDLSTGKC--LGTLrG 217

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720427389  368 HVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWD 441
Cdd:cd00200    218 HENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
50-401 2.76e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 2.76e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389   50 KLHAIMSEHKKTITAISWcphNPD--LFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWcwnTHD--AVAFVSQKG 125
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAF---SPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDgkLLASGSDDG 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  126 PLLIW---------TISGPDSGV-SVhkeahSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPGSKNQKHVLRPDSle 194
Cdd:COG2319    185 TVRLWdlatgkllrTLTGHTGAVrSV-----AFSPD-----------GKlLASGSADGTVRLWDLATGKLLRTLTGHS-- 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  195 gtdeeDPVTALEWDPLSTdYLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapG-MFITGdSQVGVLRIW 273
Cdd:COG2319    247 -----GSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRTLTGHSGGVN--SVAFSPD--GkLLASG-SDDGTVRLW 315

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  274 NVSrttpidnfklkkTGfHCFHVVNSPPKKKFSVQ-SPNKNHYISSTSeavpppnltqnqafslppghvvccflDGGVGL 352
Cdd:COG2319    316 DLA------------TG-KLLRTLTGHTGAVRSVAfSPDGKTLASGSD--------------------------DGTVRL 356

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720427389  353 YDMGAKKWdfLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINT 401
Cdd:COG2319    357 WDLATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 531-571 1.90e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.90e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1720427389   531 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 571
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 505-658 1.17e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  505 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 584
Cdd:PLN00181   540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720427389  585 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 658
Cdd:PLN00181   617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
532-571 6.54e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 6.54e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720427389  532 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 571
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-88 1.43e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.43e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1720427389    49 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 88
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 35-93 2.68e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.68e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720427389   35 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASSSTDNLVIIWNVAEQK 93
Cdd:PTZ00420    97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
49-88 3.34e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 3.34e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720427389   49 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 88
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
333-658 3.94e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.94e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  333 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 412
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  413 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 490
Cdd:COG2319    163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  491 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 568
Cdd:COG2319    239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  569 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 646
Cdd:COG2319    314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                          330
                   ....*....|..
gi 1720427389  647 CSRDSTVRLWSL 658
Cdd:COG2319    390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 367-657 3.33e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 3.33e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  367 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 446
Cdd:cd00200      7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  447 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 524
Cdd:cd00200     85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  525 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 604
Cdd:cd00200    162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720427389  605 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 657
Cdd:cd00200    238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
333-617 5.95e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.58  E-value: 5.95e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  333 AFSlPPGH-VVCCFLDGGVGLYDMGAKKwdFLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPG 410
Cdd:COG2319    127 AFS-PDGKtLASGSADGTVRLWDLATGK--LLRTLtGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTG 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  411 NEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHkDSKRIATCSGDG-FCIIRTVDGK 489
Cdd:COG2319    203 HTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHS-GSVRSVAFSP-DGRLLASGSADGtVRLWDLATGE 279

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  490 LLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVR 568
Cdd:COG2319    280 LLRTLTgHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVR 355

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1720427389  569 IWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWDTRG 617
Cdd:COG2319    356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTL-ASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 333-614 6.95e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.43  E-value: 6.95e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  333 AFSLPPGHVVCCFLDGGVGLYDMgAKKWDFLRELGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 412
Cdd:cd00200     16 AFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTLTGHT 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  413 GVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLL 491
Cdd:cd00200     94 SYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSP-DGTFVASSSQDGTIKLwDLRTGKCV 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  492 HKYK-HPAAVFGCDWSQNNKDMIATGCeDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIW 570
Cdd:cd00200    171 ATLTgHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTG--KCLGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVW 246

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1720427389  571 DYTQDACVSTLNGHTAPVRGLMWNTEIPYlLISGSWDYTIKVWD 614
Cdd:cd00200    247 DLRTGECVQTLSGHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-658 6.25e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.73  E-value: 6.25e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  407 TSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RT 485
Cdd:cd00200      4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGH-TGPVRDVAASA-DGTYLASGSSDKTIRLwDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  486 VDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlREGILCSGSDD 564
Cdd:cd00200     81 ETGECVRTLTgHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET--GKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  565 GSVRIWDYTQDACVSTLNGHTAPVRGLMWnTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtM 644
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-L 234

                          250
                   ....*....|....
gi 1720427389  645 ASCSRDSTVRLWSL 658
Cdd:cd00200    235 ASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 448-658 4.71e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 4.71e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  448 IQRFNEHGKnGIFYIAWsHKDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 525
Cdd:cd00200      2 RRTLKGHTG-GVTCVAF-SPDGKLLATGSGDGTIKVwDLETGELLRTLKgHTGPVRDVAASADGT-YLASGSSDKTIRLW 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  526 yvATSSNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGS 605
Cdd:cd00200     79 --DLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720427389  606 WDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRpFTMASCSRDSTVRLWSL 658
Cdd:cd00200    155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 534-659 2.81e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 2.81e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  534 PLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWnteIPY--LLISGSWDYTIK 611
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA---SADgtYLASGSSDKTIR 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1720427389  612 VWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWSLI 659
Cdd:cd00200     77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
421-658 3.28e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.94  E-value: 3.28e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  421 APGDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHKDSKRIATCSGDGFCIIRTVDGKLLHKYK-HPAA 499
Cdd:COG2319      2 LSADGAALAAASADLALALLAAALGALLLLLLGLA-AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  500 VFGCDWSQNNKdMIATGCEDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREGILcSGSDDGSVRIWDYTQDACVS 579
Cdd:COG2319     81 VLSVAFSPDGR-LLASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLR 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  580 TLNGHTAPVRGLMWNteiP--YLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHP-SRpfTMASCSRDSTVRLW 656
Cdd:COG2319    157 TLTGHSGAVTSVAFS---PdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdGK--LLASGSADGTVRLW 231


                   ..
gi 1720427389  657 SL 658
Cdd:COG2319    232 DL 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 51-441 1.27e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 90.86  E-value: 1.27e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389   51 LHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWNVAEQKVIAKLdniKETPACLGWCwnthdavAFVSQKGPLLIw 130
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDG-KLLATGSGDGTIKVWDLETGELLRTL---KGHTGPVRDV-------AASADGTYLAS- 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  131 tiSGPDSgvsvhkeahsfasDICIFRWHTQKKGKVAFGHidgsisifqpgsknqkhvlrpdslegtdeEDPVTALEWDPl 210
Cdd:cd00200     69 --GSSDK-------------TIRLWDLETGECVRTLTGH-----------------------------TSYVSSVAFSP- 103

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  211 STDYLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktg 290
Cdd:cd00200    104 DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVN--SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLT----- 174

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  291 fhcFHV--VNSppkkkfSVQSPNKNHYISSTSeavpppnltqnqafslppghvvccflDGGVGLYDMGAKKWdfLREL-G 367
Cdd:cd00200    175 ---GHTgeVNS------VAFSPDGEKLLSSSS--------------------------DGTIKLWDLSTGKC--LGTLrG 217

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720427389  368 HVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWD 441
Cdd:cd00200    218 HENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
50-401 2.76e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.73  E-value: 2.76e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389   50 KLHAIMSEHKKTITAISWcphNPD--LFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWcwnTHD--AVAFVSQKG 125
Cdd:COG2319    111 LLLRTLTGHTGAVRSVAF---SPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAF---SPDgkLLASGSDDG 184

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  126 PLLIW---------TISGPDSGV-SVhkeahSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPGSKNQKHVLRPDSle 194
Cdd:COG2319    185 TVRLWdlatgkllrTLTGHTGAVrSV-----AFSPD-----------GKlLASGSADGTVRLWDLATGKLLRTLTGHS-- 246

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  195 gtdeeDPVTALEWDPLSTdYLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapG-MFITGdSQVGVLRIW 273
Cdd:COG2319    247 -----GSVRSVAFSPDGR-LLASGSADGTVRLWDLATGELLRTLTGHSGGVN--SVAFSPD--GkLLASG-SDDGTVRLW 315

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  274 NVSrttpidnfklkkTGfHCFHVVNSPPKKKFSVQ-SPNKNHYISSTSeavpppnltqnqafslppghvvccflDGGVGL 352
Cdd:COG2319    316 DLA------------TG-KLLRTLTGHTGAVRSVAfSPDGKTLASGSD--------------------------DGTVRL 356

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1720427389  353 YDMGAKKWdfLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINT 401
Cdd:COG2319    357 WDLATGEL--LRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 50-274 3.71e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 3.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389   50 KLHAIMSEHKKTITAISWCPHNPdLFASSSTDNLVIIWNVAEQKVIAKLDNIKETPACLGWCWnTHDAVAFVSQKGPLLI 129
Cdd:cd00200     84 ECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKL 161

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  130 WTISgpdSGVSVHK-EAHSfaSDICIFRWHTqKKGKVAFGHIDGSISIFQPGSKNQKHVLRPDslegtdeEDPVTALEWD 208
Cdd:cd00200    162 WDLR---TGKCVATlTGHT--GEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGH-------ENGVNSVAFS 228

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720427389  209 PlSTDYLLVANLHFGIRLLDSESLYCITTFNLPSAavSVQCLAWVPSAPgMFITGdSQVGVLRIWN 274
Cdd:cd00200    229 P-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTN--SVTSLAWSPDGK-RLASG-SADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 531-571 1.90e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.90e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1720427389   531 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 571
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 505-658 1.17e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.17e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  505 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 584
Cdd:PLN00181   540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720427389  585 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 658
Cdd:PLN00181   617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
PTZ00420 PTZ00420
coronin; Provisional
 532-614 2.11e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 55.34  E-value: 2.11e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  532 NQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQD----------ACVstLNGHTAPVRGLMWNTEIPYLL 601
Cdd:PTZ00420    64 KPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWNPMNYYIM 141

                           90
                   ....*....|...
gi 1720427389  602 ISGSWDYTIKVWD 614
Cdd:PTZ00420   142 CSSGFDSFVNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
532-571 6.54e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 6.54e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720427389  532 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 571
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 577-614 1.33e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 1.33e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1720427389   577 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 614
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
577-614 8.29e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 8.29e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1720427389  577 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 614
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 366-454 1.13e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  366 LGHVETIFDCKFKPDDPNVLATASFDGTIKVWDINT--LTAVYTSP-----GNEGVIFALSWAPGDLNCIAGATSRNGAF 438
Cdd:PTZ00421    72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEegLTQNISDPivhlqGHTKKVGIVSFHPSAMNVLASAGADMVVN 151

                           90
                   ....*....|....*.
gi 1720427389  439 IWDIQKGKIIQRFNEH 454
Cdd:PTZ00421   152 VWDVERGKAVEVIKCH 167
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 439-585 4.18e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 4.18e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  439 IWDIQKGKIIQRFNEHGKNgIFYIAWSHKDSKRIATCSGDGFCIIRTVD-GKLLHKYKHPAAVFGCDWSQNNKDMIATGC 517
Cdd:PLN00181   559 VWDVARSQLVTEMKEHEKR-VWSIDYSSADPTLLASGSDDGSVKLWSINqGVSIGTIKTKANICCVQFPSESGRSLAFGS 637

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720427389  518 EDKNIrVFYVATSSNQPLKVFSGHTARVFHVKWspLREGILCSGSDDGSVRIWDYTQDAC------VSTLNGHT 585
Cdd:PLN00181   638 ADHKV-YYYDLRNPKLPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHT 708
PTZ00420 PTZ00420
coronin; Provisional
 511-571 5.69e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 5.69e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720427389  511 DMIATGCEDKNIRVFYVATSSNQ------PLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWD 571
Cdd:PTZ00420    88 EILASGSEDLTIRVWEIPHNDESvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWD 154
PTZ00420 PTZ00420
coronin; Provisional
 565-681 6.09e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 6.09e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  565 GSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-GGVCLDTVYD-------HGADVYGLTC 636
Cdd:PTZ00420    54 GAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDW 133

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1720427389  637 HPSRPFTMASCSRDSTVRLWSLIPLITPLQINI---LADRSWDeVIGN 681
Cdd:PTZ00420   134 NPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMpkkLSSLKWN-IKGN 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 367-398 1.14e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 1.14e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1720427389   367 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 398
Cdd:smart00320   10 GHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-88 1.43e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 1.43e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1720427389    49 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 88
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 530-627 1.94e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 1.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  530 SSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGSWDYT 609
Cdd:PTZ00421   113 NISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLD-GSLLCTTSKDKK 191

                           90
                   ....*....|....*...
gi 1720427389  610 IKVWDTRGGVCLDTVYDH 627
Cdd:PTZ00421   192 LNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
367-398 2.99e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.99e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1720427389  367 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 398
Cdd:pfam00400    9 GHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
618-657 3.24e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.24e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720427389  618 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 657
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 618-657 4.21e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 4.21e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1720427389   618 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 657
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 530-655 4.53e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 4.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  530 SSNQPLKVfsGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVST-------LNGHTAPVRGLMWNTEIPYLLI 602
Cdd:PTZ00421    65 ASNPPILL--GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVLA 142

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1720427389  603 SGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHpSRPFTMASCSRDSTVRL 655
Cdd:PTZ00421   143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNI 194
PTZ00421 PTZ00421
coronin; Provisional
 367-454 1.49e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 1.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389  367 GHVETIFDCKFKPDDPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSW-APGDLNCiagATSRNGAF-IWDIQK 444
Cdd:PTZ00421   123 GHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWnLDGSLLC---TTSKDKKLnIIDPRD 199

                           90
                   ....*....|
gi 1720427389  445 GKIIQRFNEH 454
Cdd:PTZ00421   200 GTIVSSVEAH 209
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 18-98 1.54e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.94  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720427389   18 NKDVCAANGDRFaycatlaIYIYQLDhrynEFKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWNVAEQKVIAK 97
Cdd:cd00200    189 GEKLLSSSSDGT-------IKLWDLS----TGKCLGTLRGHENGVNSVAFSPDG-YLLASGSEDGTIRVWDLRTGECVQT 256


                   .
gi 1720427389   98 L 98
Cdd:cd00200    257 L 257
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 487-525 1.64e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.64e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1720427389   487 DGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 525
Cdd:smart00320    1 SGELLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 590-658 2.59e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 2.59e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720427389  590 GLMWNTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 658
Cdd:PLN00181   537 GICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI 605
PTZ00420 PTZ00420
coronin; Provisional
 35-93 2.68e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 2.68e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720427389   35 LAIYIYQLDHR---YNEFK-LHAIMSEHKKTITAISWCPHNPDLFASSSTDNLVIIWNVAEQK 93
Cdd:PTZ00420    97 LTIRVWEIPHNdesVKEIKdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEK 159
WD40 pfam00400
WD domain, G-beta repeat;
49-88 3.34e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 3.34e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720427389   49 FKLHAIMSEHKKTITAISWCPHNpDLFASSSTDNLVIIWN 88
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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