|
Name |
Accession |
Description |
Interval |
E-value |
| PL48 super family |
cl24470 |
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ... |
30-207 |
1.08e-123 |
|
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.
The actual alignment was detected with superfamily member pfam15903:
Pssm-ID: 464930 Cd Length: 297 Bit Score: 379.82 E-value: 1.08e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 30 TESMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSEETVFLPLLTEFLSIK 109
Cdd:pfam15903 120 SKDMCLLEGELENLLGEFHIKMKGLAGFARLCPGDQYEVLMRYGRQRWKLRGRIETDDKQVWDEEEMVFLPLIHENFEIK 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 110 VTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIWSPFDKDDQPSAASTVNKASTVTKRFSTYSQS 189
Cdd:pfam15903 200 VTELKGLANHVLVGSVTCETKDLFAARPQVVAVDINDLGTIKLQLEVTWNPFDKEDQLPSASSVSKASVVSRRGSVYSWT 279
|
170
....*....|....*...
gi 1720428612 190 PPDTPSLREQAFYNMLRR 207
Cdd:pfam15903 280 PPDTPSFREKYFLSMLRQ 297
|
|
| Herpes_BLLF1 super family |
cl37540 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
286-591 |
7.44e-10 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
The actual alignment was detected with superfamily member pfam05109:
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 63.40 E-value: 7.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 286 SRTLSHISEASVDAALTEAVEAVdSQSPIPGPSPLVYPDSTHVERVSSVLPVLNNGHSATSPALST---TGPAP------ 356
Cdd:pfam05109 406 TRTATNATTTTHKVIFSKAPEST-TTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTadvTSPTPagttsg 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 357 -TFIDPAPTTQLDLVHKTTDSAPSELPSITHTTTSSAYSAVSLVNSVPSLTSTTIGSAHTTTPSPLtstgSVPNATdstq 435
Cdd:pfam05109 485 aSPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTT----PTPNAT---- 556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 436 aTPSPTHSTPSPTHTTIRLTHTT-----VSPTHSSPSPIHTTPSPTHTTVSPTCTTPSSGHSTTSPTQEAkMSTHTTGAV 510
Cdd:pfam05109 557 -SPTPAVTTPTPNATIPTLGKTSptsavTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNA-TSAVTTGQH 634
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 511 GPVQTTTS-----PISTTESPSPSTdvaiissssaesTGPGTEPLPCSHPASPP----YTKADPTASCTSYQSLASSGSK 581
Cdd:pfam05109 635 NITSSSTSsmslrPSSISETLSPST------------SDNSTSHMPLLTSAHPTggenITQVTPASTSTHHVSTSSPAPR 702
|
330
....*....|
gi 1720428612 582 PLTSPAPDSP 591
Cdd:pfam05109 703 PGTTSQASGP 712
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
911-1032 |
3.07e-07 |
|
HEAT repeat [General function prediction only];
:
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 50.78 E-value: 3.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 911 LLVQNLNSDDQAVVLKALRLApeGRLR-KDGLRALSSLLVHGNNKVMAAVStqlrsLSLGPVFRERALLCFLDQLEDGDV 989
Cdd:COG1413 20 ALIAALADEDPDVRAAAARAL--GRLGdPRAVPALLEALKDPDPEVRAAAA-----EALGRIGDPEAVPALIAALKDEDP 92
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1720428612 990 QTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQ 1032
Cdd:COG1413 93 EVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGR 135
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PL48 |
pfam15903 |
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ... |
30-207 |
1.08e-123 |
|
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.
Pssm-ID: 464930 Cd Length: 297 Bit Score: 379.82 E-value: 1.08e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 30 TESMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSEETVFLPLLTEFLSIK 109
Cdd:pfam15903 120 SKDMCLLEGELENLLGEFHIKMKGLAGFARLCPGDQYEVLMRYGRQRWKLRGRIETDDKQVWDEEEMVFLPLIHENFEIK 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 110 VTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIWSPFDKDDQPSAASTVNKASTVTKRFSTYSQS 189
Cdd:pfam15903 200 VTELKGLANHVLVGSVTCETKDLFAARPQVVAVDINDLGTIKLQLEVTWNPFDKEDQLPSASSVSKASVVSRRGSVYSWT 279
|
170
....*....|....*...
gi 1720428612 190 PPDTPSLREQAFYNMLRR 207
Cdd:pfam15903 280 PPDTPSFREKYFLSMLRQ 297
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
286-591 |
7.44e-10 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 63.40 E-value: 7.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 286 SRTLSHISEASVDAALTEAVEAVdSQSPIPGPSPLVYPDSTHVERVSSVLPVLNNGHSATSPALST---TGPAP------ 356
Cdd:pfam05109 406 TRTATNATTTTHKVIFSKAPEST-TTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTadvTSPTPagttsg 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 357 -TFIDPAPTTQLDLVHKTTDSAPSELPSITHTTTSSAYSAVSLVNSVPSLTSTTIGSAHTTTPSPLtstgSVPNATdstq 435
Cdd:pfam05109 485 aSPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTT----PTPNAT---- 556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 436 aTPSPTHSTPSPTHTTIRLTHTT-----VSPTHSSPSPIHTTPSPTHTTVSPTCTTPSSGHSTTSPTQEAkMSTHTTGAV 510
Cdd:pfam05109 557 -SPTPAVTTPTPNATIPTLGKTSptsavTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNA-TSAVTTGQH 634
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 511 GPVQTTTS-----PISTTESPSPSTdvaiissssaesTGPGTEPLPCSHPASPP----YTKADPTASCTSYQSLASSGSK 581
Cdd:pfam05109 635 NITSSSTSsmslrPSSISETLSPST------------SDNSTSHMPLLTSAHPTggenITQVTPASTSTHHVSTSSPAPR 702
|
330
....*....|
gi 1720428612 582 PLTSPAPDSP 591
Cdd:pfam05109 703 PGTTSQASGP 712
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
911-1032 |
3.07e-07 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 50.78 E-value: 3.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 911 LLVQNLNSDDQAVVLKALRLApeGRLR-KDGLRALSSLLVHGNNKVMAAVStqlrsLSLGPVFRERALLCFLDQLEDGDV 989
Cdd:COG1413 20 ALIAALADEDPDVRAAAARAL--GRLGdPRAVPALLEALKDPDPEVRAAAA-----EALGRIGDPEAVPALIAALKDEDP 92
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1720428612 990 QTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQ 1032
Cdd:COG1413 93 EVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGR 135
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
341-551 |
2.30e-06 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 51.68 E-value: 2.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 341 GHSATSPALSTTGPAPTFIDPAPTTQLDLVHKTTDSAPSELPSITHTTTSSAYSAVSLVNSVPSLTSTTIGSAHTTTPSP 420
Cdd:COG3469 8 ASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 421 LTSTGSVPNATDSTQATPSPTHSTPSPTHTTIRLTHTTVSPTHSSPSPIHTTPSpthttVSPTCTTPSSGHSTTSPTQEA 500
Cdd:COG3469 88 AATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASAT-----SSAGSTTTTTTVSGTETATGG 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1720428612 501 KMSTHTTGAVGPVQTTTSPISTTESPSPSTDVAIISSSSAESTGPGTEPLP 551
Cdd:COG3469 163 TTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLP 213
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
941-1031 |
4.03e-04 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 40.40 E-value: 4.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 941 LRALSSLLVHGNNKVMAAVSTQlrslSLGPVFRERALLCFLDQLEDGDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTE 1020
Cdd:pfam13646 1 LPALLQALLRDPDPEVRAAAIR----ALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDDDD 76
|
90
....*....|..
gi 1720428612 1021 A-VREAARQSLQ 1031
Cdd:pfam13646 77 DvVRAAAAEALA 88
|
|
| PHA03255 |
PHA03255 |
BDLF3; Provisional |
483-585 |
1.87e-03 |
|
BDLF3; Provisional
Pssm-ID: 165513 [Multi-domain] Cd Length: 234 Bit Score: 41.04 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 483 TCTTPSSGhSTTSPTQEAKMSTHTTGAVGPVQTTTSPISTTESPSPSTDVAIISSSSAESTGPGTEPLPCSHPASPPYTK 562
Cdd:PHA03255 25 TSSGSSTA-SAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPVPTTSNASTINVT 103
|
90 100
....*....|....*....|...
gi 1720428612 563 ADPTASCTSYQSLASSGSKPLTS 585
Cdd:PHA03255 104 TKVTAQNITATEAGTGTSTGVTS 126
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PL48 |
pfam15903 |
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ... |
30-207 |
1.08e-123 |
|
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.
Pssm-ID: 464930 Cd Length: 297 Bit Score: 379.82 E-value: 1.08e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 30 TESMCLLENELEAQLGEFHLRMKGLAGFARLCVGDQYEICMKYGRQRWKLRGRIESSGKQVWDSEETVFLPLLTEFLSIK 109
Cdd:pfam15903 120 SKDMCLLEGELENLLGEFHIKMKGLAGFARLCPGDQYEVLMRYGRQRWKLRGRIETDDKQVWDEEEMVFLPLIHENFEIK 199
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 110 VTELKGLANHVVVGSVSCETKDLFAALPQVVAVDINDLGTIKLSLEVIWSPFDKDDQPSAASTVNKASTVTKRFSTYSQS 189
Cdd:pfam15903 200 VTELKGLANHVLVGSVTCETKDLFAARPQVVAVDINDLGTIKLQLEVTWNPFDKEDQLPSASSVSKASVVSRRGSVYSWT 279
|
170
....*....|....*...
gi 1720428612 190 PPDTPSLREQAFYNMLRR 207
Cdd:pfam15903 280 PPDTPSFREKYFLSMLRQ 297
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
286-591 |
7.44e-10 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 63.40 E-value: 7.44e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 286 SRTLSHISEASVDAALTEAVEAVdSQSPIPGPSPLVYPDSTHVERVSSVLPVLNNGHSATSPALST---TGPAP------ 356
Cdd:pfam05109 406 TRTATNATTTTHKVIFSKAPEST-TTSPTLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTadvTSPTPagttsg 484
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 357 -TFIDPAPTTQLDLVHKTTDSAPSELPSITHTTTSSAYSAVSLVNSVPSLTSTTIGSAHTTTPSPLtstgSVPNATdstq 435
Cdd:pfam05109 485 aSPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVTT----PTPNAT---- 556
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 436 aTPSPTHSTPSPTHTTIRLTHTT-----VSPTHSSPSPIHTTPSPTHTTVSPTCTTPSSGHSTTSPTQEAkMSTHTTGAV 510
Cdd:pfam05109 557 -SPTPAVTTPTPNATIPTLGKTSptsavTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNA-TSAVTTGQH 634
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 511 GPVQTTTS-----PISTTESPSPSTdvaiissssaesTGPGTEPLPCSHPASPP----YTKADPTASCTSYQSLASSGSK 581
Cdd:pfam05109 635 NITSSSTSsmslrPSSISETLSPST------------SDNSTSHMPLLTSAHPTggenITQVTPASTSTHHVSTSSPAPR 702
|
330
....*....|
gi 1720428612 582 PLTSPAPDSP 591
Cdd:pfam05109 703 PGTTSQASGP 712
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
911-1032 |
3.07e-07 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 50.78 E-value: 3.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 911 LLVQNLNSDDQAVVLKALRLApeGRLR-KDGLRALSSLLVHGNNKVMAAVStqlrsLSLGPVFRERALLCFLDQLEDGDV 989
Cdd:COG1413 20 ALIAALADEDPDVRAAAARAL--GRLGdPRAVPALLEALKDPDPEVRAAAA-----EALGRIGDPEAVPALIAALKDEDP 92
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1720428612 990 QTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQ 1032
Cdd:COG1413 93 EVRRAAAEALGRLGDPAAVPALLEALKDPDWEVRRAAARALGR 135
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
934-1049 |
1.40e-06 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 48.86 E-value: 1.40e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 934 GRLR-KDGLRALSSLLVHGNNKV-MAAVStqlrslSLGPVFRERALLCFLDQLEDGDVQTRVAGCLALGCIKAPEGIEPL 1011
Cdd:COG1413 10 GRLGdPAAVPALIAALADEDPDVrAAAAR------ALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDPEAVPAL 83
|
90 100 110
....*....|....*....|....*....|....*...
gi 1720428612 1012 VYLCQTDTEAVREAARQSLQQCGEEgqSAHRQLEESLD 1049
Cdd:COG1413 84 IAALKDEDPEVRRAAAEALGRLGDP--AAVPALLEALK 119
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
341-551 |
2.30e-06 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 51.68 E-value: 2.30e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 341 GHSATSPALSTTGPAPTFIDPAPTTQLDLVHKTTDSAPSELPSITHTTTSSAYSAVSLVNSVPSLTSTTIGSAHTTTPSP 420
Cdd:COG3469 8 ASPTAGGASATAVTLLGAAATAASVTLTAATATTVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 421 LTSTGSVPNATDSTQATPSPTHSTPSPTHTTIRLTHTTVSPTHSSPSPIHTTPSpthttVSPTCTTPSSGHSTTSPTQEA 500
Cdd:COG3469 88 AATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTTTSGASAT-----SSAGSTTTTTTVSGTETATGG 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1720428612 501 KMSTHTTGAVGPVQTTTSPISTTESPSPSTDVAIISSSSAESTGPGTEPLP 551
Cdd:COG3469 163 TTTTSTTTTTTSASTTPSATTTATATTASGATTPSATTTATTTGPPTPGLP 213
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
331-532 |
3.07e-05 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 47.83 E-value: 3.07e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 331 VSSVLPVLNNGHSATSPALSTTGPAPTfidpAPTTQLDLVHKTTDSAPSELPSITHTTTSSAYSAVSLVNSVPSLTSTTI 410
Cdd:COG3469 42 VVSTTGSVVVAASGSAGSGTGTTAASS----TAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTST 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 411 GSAhtttpspLTSTGSVPNATDSTQATPSPTHSTPSPTHTTIRLTHTTVSPThsspspihttpspthTTVSPTCTTPSSG 490
Cdd:COG3469 118 GAG-------SVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGG---------------TTTTSTTTTTTSA 175
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1720428612 491 HSTTSPTqeakmSTHTTGAVGPVQTTTSPISTTESPSPSTDV 532
Cdd:COG3469 176 STTPSAT-----TTATATTASGATTPSATTTATTTGPPTPGL 212
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
282-593 |
4.74e-05 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 47.26 E-value: 4.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 282 HAPYSRTLSH--ISEASVDAALTEAVEAVDSQSPIPG----PSPLVYPDSTHVERVSSVLPVLNNghSATSPALSTTGPA 355
Cdd:pfam17823 90 HTPHGTDLSEpaTREGAADGAASRALAAAASSSPSSAaqslPAAIAALPSEAFSAPRAAACRANA--SAAPRAAIAAASA 167
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 356 PTFIDPAPTTQldlvhKTTDSAPSELPSITHTTTSSAYSAVSLVNSVPSLTSTTIGSAHTTTPSPLTSTGS---VPNATD 432
Cdd:pfam17823 168 PHAASPAPRTA-----ASSTTAASSTTAASSAPTTAASSAPATLTPARGISTAATATGHPAAGTALAAVGNsspAAGTVT 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 433 STQATPSP----THSTPSPTHTTIRLTHTTVSPTHSSPSPIHTTPSPTHTTvSPTCTTPSSGHSTTSPTQEAKMSTHTTG 508
Cdd:pfam17823 243 AAVGTVTPaalaTLAAAAGTVASAAGTINMGDPHARRLSPAKHMPSDTMAR-NPAAPMGAQAQGPIIQVSTDQPVHNTAG 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 509 AVGPVQTTTSPISTTESPSPSTDVAIISSSSAESTGPGTEPLPCSHPASPPYTKAdptasctsyqslassgSKPLTSPAP 588
Cdd:pfam17823 322 EPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEVEA----------------TSPTTQPSP 385
|
....*
gi 1720428612 589 DSPEQ 593
Cdd:pfam17823 386 LLPTQ 390
|
|
| HEAT |
COG1413 |
HEAT repeat [General function prediction only]; |
967-1036 |
4.96e-05 |
|
HEAT repeat [General function prediction only];
Pssm-ID: 441023 [Multi-domain] Cd Length: 137 Bit Score: 44.23 E-value: 4.96e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 967 SLGPVFRERALLCFLDQLEDGDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQCGEE 1036
Cdd:COG1413 8 ALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGDPRAVPALLEALKDPDPEVRAAAAEALGRIGDP 77
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
344-625 |
3.47e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 44.57 E-value: 3.47e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 344 ATSPALSTTGPAPTFIDPAPTTQLDLVHKTTDSAP--------SELPSITHTTTSSAYSAV-----SLVNSVPSLTSTTI 410
Cdd:pfam17823 66 APAPVTLTKGTSAAHLNSTEVTAEHTPHGTDLSEPatregaadGAASRALAAAASSSPSSAaqslpAAIAALPSEAFSAP 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 411 GSAHTTTPSPLTSTGSVPNATDSTQATPSPTHSTPSPT--HTTIRLTHTTVSPTHSSPS---PIHTTPSPTHTTVSPTCT 485
Cdd:pfam17823 146 RAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTaaSSTTAASSAPTTAASSAPAtltPARGISTAATATGHPAAG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 486 TPSSGHSTTSP---TQEAKMSTHTTGAVGPVQT-------------TTSPISTTESPSPSTDVAIISSSSAESTGPGTEp 549
Cdd:pfam17823 226 TALAAVGNSSPaagTVTAAVGTVTPAALATLAAaagtvasaagtinMGDPHARRLSPAKHMPSDTMARNPAAPMGAQAQ- 304
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720428612 550 lpcshpasppytkaDPTASCTSYQSLASSGSKPLTSPAPDSPEQIPKSPSSSPSSSAPEPQHSEHNLAAVAQAPVP 625
Cdd:pfam17823 305 --------------GPIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVL 366
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
941-1031 |
4.03e-04 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 40.40 E-value: 4.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 941 LRALSSLLVHGNNKVMAAVSTQlrslSLGPVFRERALLCFLDQLEDGDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTE 1020
Cdd:pfam13646 1 LPALLQALLRDPDPEVRAAAIR----ALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPALLELLRDDDD 76
|
90
....*....|..
gi 1720428612 1021 A-VREAARQSLQ 1031
Cdd:pfam13646 77 DvVRAAAAEALA 88
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
260-530 |
4.27e-04 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 44.18 E-value: 4.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 260 PESLTSGSMDEEPAMTPSLVNGHAPYSRTLShiSEASVDAALTEAVEAVDSQSPIPGPSPLVYPDSTHVERVSSVLPVLN 339
Cdd:pfam17823 137 LPSEAFSAPRAAACRANASAAPRAAIAAASA--PHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGIST 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 340 NGHSATSPALSTTGPAPTFIDPAPTTQLDLVHKTTDSAPSELPSITHTTTSSA--YSAVSLVNSVPSLTSTTigSAHTTT 417
Cdd:pfam17823 215 AATATGHPAAGTALAAVGNSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAgtINMGDPHARRLSPAKHM--PSDTMA 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 418 PSPLTSTGSVPNATDSTQATPSPTHST-PSPTHTTIRLTHTTVSPTHSSPSPIHTTPSPTHTTVSPTCTTPSSGHST--- 493
Cdd:pfam17823 293 RNPAAPMGAQAQGPIIQVSTDQPVHNTaGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSmip 372
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 1720428612 494 ----TSPTQEAKMSTHTTGAVGP--------VQTTTSPISTTESPSPST 530
Cdd:pfam17823 373 eveaTSPTTQPSPLLPTQGAAGPgillapeqVATEATAGTASAGPTPRS 421
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
241-626 |
1.27e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 42.83 E-value: 1.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 241 PKPLVQQPEPLPVQVAFRRPESLTSGSMDEEPAM-------------TPSLVNGHAPYSRTLShiSEASVDAALTEAvea 307
Cdd:pfam03154 65 SSKKIKEEAPSPLKSAKRQREKGASDTEEPERATakksktqeisrpnSPSEGEGESSDGRSVN--DEGSSDPKDIDQ--- 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 308 vDSQSPIPG-PSPL---VYPDSTHVERVSSVLPVLNNGHSATSPALSTTGPAPTFI-DPAPTTQLDLVHKTTDSAPSELP 382
Cdd:pfam03154 140 -DNRSTSPSiPSPQdneSDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAaTAGPTPSAPSVPPQGSPATSQPP 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 383 SITHTTTSSaysaVSLVNSVPSLTSTTIGSAHTTTPSPLTSTgsvPNATDSTQATPSPTHSTPSPTHTTIRLTHTTVSPT 462
Cdd:pfam03154 219 NQTQSTAAP----HTLIQQTPTLHPQRLPSPHPPLQPMTQPP---PPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQH 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 463 HSSPSPIHTTPSPTHTTVSPTCTTPSSGHSTTSPTQEAKMSTHTTGAVGPVQT--------------TTSPISTTESPSP 528
Cdd:pfam03154 292 PVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPlppaplsmphikppPTTPIPQLPNPQS 371
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 529 STDVAIISSSSAESTGPGTEPLPCSHPASPPYTKADPTASCTSYQSLasSGSKPLTSPaPDSPEQIPKSPSSSPSSSAPE 608
Cdd:pfam03154 372 HKHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLM--PQSQQLPPP-PAQPPVLTQSQSLPPPAASHP 448
|
410
....*....|....*...
gi 1720428612 609 PQHSEHNLAavAQAPVPE 626
Cdd:pfam03154 449 PTSGLHQVP--SQSPFPQ 464
|
|
| PHA03255 |
PHA03255 |
BDLF3; Provisional |
483-585 |
1.87e-03 |
|
BDLF3; Provisional
Pssm-ID: 165513 [Multi-domain] Cd Length: 234 Bit Score: 41.04 E-value: 1.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 483 TCTTPSSGhSTTSPTQEAKMSTHTTGAVGPVQTTTSPISTTESPSPSTDVAIISSSSAESTGPGTEPLPCSHPASPPYTK 562
Cdd:PHA03255 25 TSSGSSTA-SAGNVTGTTAVTTPSPSASGPSTNQSTTLTTTSAPITTTAILSTNTTTVTSTGTTVTPVPTTSNASTINVT 103
|
90 100
....*....|....*....|...
gi 1720428612 563 ADPTASCTSYQSLASSGSKPLTS 585
Cdd:PHA03255 104 TKVTAQNITATEAGTGTSTGVTS 126
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
255-592 |
3.12e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 41.70 E-value: 3.12e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 255 VAFRRPESLTSGSMDEEPAMTPSLVNGHAPYSRTLSHISEASVDAALTEAVEAVDSQSPIPGPSPLVYPDSTHVERVSSV 334
Cdd:PHA03307 55 VVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDL 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 335 LPVLNNGHSATSPALSTTGPAPtfiDPAPTTQLDLVHKTTDSAPSELPSITHTTTSSAYSAVSlVNSVPSLTSTTIGSAH 414
Cdd:PHA03307 135 SEMLRPVGSPGPPPAASPPAAG---ASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPP-PSTPPAAASPRPPRRS 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 415 TTTPSPLTSTGSVP--NATDSTQATPSPTHSTPSPTHTTIRLTHTTVSPTHSSPSPIHTTPSPTHTTVSPTCTTPSSGHS 492
Cdd:PHA03307 211 SPISASASSPAPAPgrSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSS 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 493 TTSPTQEAKMSThttgAVGPVQTTTSPISTTESPSPSTDVAIISSSSAESTGPGTEPLP-CSHPASPPYTKADPTASCTS 571
Cdd:PHA03307 291 PRERSPSPSPSS----PGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPsPSRSPSPSRPPPPADPSSPR 366
|
330 340
....*....|....*....|.
gi 1720428612 572 yQSLASSGSKPLTSPAPDSPE 592
Cdd:PHA03307 367 -KRPRPSRAPSSPAASAGRPT 386
|
|
| HEAT_2 |
pfam13646 |
HEAT repeats; This family includes multiple HEAT repeats. |
984-1049 |
3.63e-03 |
|
HEAT repeats; This family includes multiple HEAT repeats.
Pssm-ID: 433376 [Multi-domain] Cd Length: 88 Bit Score: 37.70 E-value: 3.63e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720428612 984 LEDGDVQTRVAGCLALGCIKAPEGIEPLVYLCQTDTEAVREAARQSLQQCGEEGQSAHrqLEESLD 1049
Cdd:pfam13646 9 LRDPDPEVRAAAIRALGRIGDPEAVPALLELLKDEDPAVRRAAAEALGKIGDPEALPA--LLELLR 72
|
|
| Chi1 |
COG3469 |
Chitinase [Carbohydrate transport and metabolism]; |
310-496 |
5.76e-03 |
|
Chitinase [Carbohydrate transport and metabolism];
Pssm-ID: 442692 [Multi-domain] Cd Length: 534 Bit Score: 40.51 E-value: 5.76e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 310 SQSPIPGPSPLVYPDSTHVERVSSVLPVLNNGHSATSPALSTTGPAPTFIDPAPTTqldlvhkTTDSAPSELPSITHTTT 389
Cdd:COG3469 41 TVVSTTGSVVVAASGSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATL-------VATSTASGANTGTSTVT 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720428612 390 SSAYSAVSLVNSVPSLTSTTIGSAHTTTPSPLTSTGSVPNATDSTQATPSPTHSTPSPTHTTirlthtTVSPTHSSPSPI 469
Cdd:COG3469 114 TTSTGAGSVTSTTSSTAGSTTTSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTTTSA------STTPSATTTATA 187
|
170 180
....*....|....*....|....*..
gi 1720428612 470 HTTPSPTHTTVSPTcTTPSSGHSTTSP 496
Cdd:COG3469 188 TTASGATTPSATTT-ATTTGPPTPGLP 213
|
|
| |
