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Conserved domains on  [gi|1720362323|ref|XP_030101150|]
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R3H domain-containing protein 2 isoform X5 [Mus musculus]

Protein Classification

SANT/Myb-like DNA-binding domain-containing protein; MFS transporter( domain architecture ID 11552550)

SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain-containing protein binds DNA and may function as a transcription factor; also contains a Med15 domain, a critical transducer of gene activation signals that control early metazoan development.| major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 168-229 2.62e-27

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


:

Pssm-ID: 100071  Cd Length: 63  Bit Score: 105.38  E-value: 2.62e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720362323 168 DRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTG-KAVIINKT 229
Cdd:cd02642     1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
Med15 super family cl26621
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 401-750 2.60e-11

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


The actual alignment was detected with superfamily member pfam09606:

Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 67.73  E-value: 2.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 401 LPPTPQHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQVLLPVSPPQQYNMAEDLSNPF--GQMSLSRQGSTEAADPSS 478
Cdd:pfam09606 124 LASLGRPQMPMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGqaGGMNGGQQGPMGGQMPPQ 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 479 ALFQPPLISQHPQQASFIMASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQppQQIQVSYYPPGQYPNSNQQYRPLSHPV 558
Cdd:pfam09606 204 MGVPGMPGPADAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQ--SQLGMGINQMQQMPQGVGGGAGQGGPG 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 559 AYSPQRGQQLPQASQQ--PGLQPMMSNQQQTAYQGMLGVQQPQNQGLLSNQRSSMGGQMQ---GLVVQYTPLPSYQVPVG 633
Cdd:pfam09606 282 QPMGPPGQQPGAMPNVmsIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVValgGLNHLETWNPGNFGGLG 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 634 SDSQNVVQP---SFQQPMLVPASQSVQG--GLPTGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQ 708
Cdd:pfam09606 362 ANPMQRGQPgmmSSPSPVPGQQVRQVTPnqFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQR 441

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1720362323 709 MSQQYSGVSPSG-PGVVVMqlNVPNGPQAPQNPSMVQWSHCKY 750
Cdd:pfam09606 442 TIGQDSPGGSLNtPGQSAV--NSPLNPQEEQLYREKYRQLTKY 482
 
Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 168-229 2.62e-27

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 105.38  E-value: 2.62e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720362323 168 DRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTG-KAVIINKT 229
Cdd:cd02642     1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
152-229 1.00e-14

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 70.02  E-value: 1.00e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  152 IDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINdNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKA--VIINKT 229
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVK-STKESVELPPMNSYERKIVHELAEKYGLESESFGEGPKrrVVISKK 79
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 401-750 2.60e-11

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 67.73  E-value: 2.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 401 LPPTPQHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQVLLPVSPPQQYNMAEDLSNPF--GQMSLSRQGSTEAADPSS 478
Cdd:pfam09606 124 LASLGRPQMPMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGqaGGMNGGQQGPMGGQMPPQ 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 479 ALFQPPLISQHPQQASFIMASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQppQQIQVSYYPPGQYPNSNQQYRPLSHPV 558
Cdd:pfam09606 204 MGVPGMPGPADAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQ--SQLGMGINQMQQMPQGVGGGAGQGGPG 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 559 AYSPQRGQQLPQASQQ--PGLQPMMSNQQQTAYQGMLGVQQPQNQGLLSNQRSSMGGQMQ---GLVVQYTPLPSYQVPVG 633
Cdd:pfam09606 282 QPMGPPGQQPGAMPNVmsIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVValgGLNHLETWNPGNFGGLG 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 634 SDSQNVVQP---SFQQPMLVPASQSVQG--GLPTGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQ 708
Cdd:pfam09606 362 ANPMQRGQPgmmSSPSPVPGQQVRQVTPnqFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQR 441

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1720362323 709 MSQQYSGVSPSG-PGVVVMqlNVPNGPQAPQNPSMVQWSHCKY 750
Cdd:pfam09606 442 TIGQDSPGGSLNtPGQSAV--NSPLNPQEEQLYREKYRQLTKY 482
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 170-228 1.05e-10

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 57.89  E-value: 1.05e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720362323 170 MMLLKLEQEILDFINDNNNQFKkFPQMTSYHRMLLHRVAAYFGMDHNV--DQTGKAVIINK 228
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLE-LPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
PHA03379 PHA03379
EBNA-3A; Provisional
 419-798 3.47e-06

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 51.21  E-value: 3.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 419 PVPALQPSPQPVQFSPSSCPQVLLPVSPPQQYNMAEDLSNPFgqmSLSRQGSTEAADPSSALFQP--PLISQHPQQASFI 496
Cdd:PHA03379  447 PVHDLEPGPLHDQHSMAPCPVAQLPPGPLQDLEPGDQLPGVV---QDGRPACAPVPAPAGPIVRPweASLSQVPGVAFAP 523

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 497 MAS---AGQPLPTSNYSTSSHAPPtqqvLPPQGYMQPP------QQIQVSYYPPGQYPNSNQQYRPLshPVAYSPQRGQQ 567
Cdd:PHA03379  524 VMPqpmPVEPVPVPTVALERPVCP----APPLIAMQGPgetsgiVRVRERWRPAPWTPNPPRSPSQM--SVRDRLARLRA 597

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 568 LPQASQQP-GLQPMMSNQQQTayqgmlgvQQPQNQGLLSNQRSSMGGQMQGL--VVQYTPLPSYQVPvgSDSQNVVQPSF 644
Cdd:PHA03379  598 EAQPYQASvEVQPPQLTQVSP--------QQPMEYPLEPEQQMFPGSPFSQVadVMRAGGVPAMQPQ--YFDLPLQQPIS 667

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 645 QQPMLVPASQSVQGGLPTGGVPVYYSMIPPAQQ--NGTSPSVGFLQPPGS-------EQYQMPQSPSPCSPPQMSQQYSG 715
Cdd:PHA03379  668 QGAPLAPLRASMGPVPPVPATQPQYFDIPLTEPinQGASAAHFLPQQPMEgplvperWMFQGATLSQSVRPGVAQSQYFD 747

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 716 VSPSGPgvvvMQLNVPNGPQAPQNPSMVQWshckyysVEQRGQKPGDLYSPdGSPQANAQMGSSPVTSPTQSPAPSPVTS 795
Cdd:PHA03379  748 LPLTQP----INHGAPAAHFLHQPPMEGPW-------VPEQWMFQGAPPSQ-GTDVVQHQLDALGYVLHVLNHPGVPVSP 815


                  ...
gi 1720362323 796 LSN 798
Cdd:PHA03379  816 AVN 818
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 456-625 1.48e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.57  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 456 LSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQASfimasAGQPLptsNYstsshaPPTQQVLPPQGYMQPPQQIQ 535
Cdd:TIGR01628 371 LQDQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQQF-----NGQPL---GW------PRMSMMPTPMGPGGPLRPNG 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 536 VSYYPPGQYPNSNQQYRPLSHPVA---YSPQ-RGQQLPQASQQPGLQPMMSNQQQTAYQgMLGVQQPQnqgllsNQRSSM 611
Cdd:TIGR01628 437 LAPMNAVRAPSRNAQNAAQKPPMQpvmYPPNyQSLPLSQDLPQPQSTASQGGQNKKLAQ-VLASATPQ------MQKQVL 509

                         170
                  ....*....|....
gi 1720362323 612 GGQMQGLVVQYTPL 625
Cdd:TIGR01628 510 GERLFPLVEAIEPA 523
Amelin smart00817
Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin ...
 467-602 5.77e-03

Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although their volumetric percentage is low, have an important role in enamel mineralisation. One of the non-amelogenin proteins is ameloblastin, also known as amelin and sheathlin. Ameloblastin (AMBN) is one of the enamel sheath proteins which is though to have a role in determining the prismatic structure of growing enamel crystals.


Pssm-ID: 214832 [Multi-domain]  Cd Length: 411  Bit Score: 40.26  E-value: 5.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  467 RQGSTEAADPSSALFQPPLISQHPQQAsfimasagqPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYPPGQYPN 546
Cdd:smart00817  82 REHETQQYEYSLPVHPPPLPSQPSLQP---------QQPGLKPFLQPTALPTNQATPQKNGPQPPMHLGQPPLQQAELPM 152

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720362323  547 SNQQYRPLSHP-------VAYSPQRGQQLPQASQQPGLQPMMSNQQQTAYQGMLGVQQPQNQG 602
Cdd:smart00817 153 IPPQVAPSDKPpqtelplYDFADPQNPLLFQIAHLMSRGPMPQNKQQHLYPGLFYMSYGANQL 215
 
Name Accession Description Interval E-value
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 168-229 2.62e-27

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 105.38  E-value: 2.62e-27
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720362323 168 DRMMLLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTG-KAVIINKT 229
Cdd:cd02642     1 DRLFVLKLEKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGgKCVIVNKT 63
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
152-229 1.00e-14

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 70.02  E-value: 1.00e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  152 IDLHEFLVNTLKKNPRDRMMLLKLEQEILDFINdNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTGKA--VIINKT 229
Cdd:smart00393   1 ADFLPVTLDALSYRPRRREELIELELEIARFVK-STKESVELPPMNSYERKIVHELAEKYGLESESFGEGPKrrVVISKK 79
Med15 pfam09606
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ...
 401-750 2.60e-11

ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.


Pssm-ID: 312941 [Multi-domain]  Cd Length: 732  Bit Score: 67.73  E-value: 2.60e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 401 LPPTPQHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQVLLPVSPPQQYNMAEDLSNPF--GQMSLSRQGSTEAADPSS 478
Cdd:pfam09606 124 LASLGRPQMPMGGAGFPSQMSRVGRMQPGGQAGGMMQPSSGQPGSGTPNQMGPNGGPGQGqaGGMNGGQQGPMGGQMPPQ 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 479 ALFQPPLISQHPQQASFIMASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQppQQIQVSYYPPGQYPNSNQQYRPLSHPV 558
Cdd:pfam09606 204 MGVPGMPGPADAGAQMGQQAQANGGMNPQQMGGAPNQVAMQQQQPQQQGQQ--SQLGMGINQMQQMPQGVGGGAGQGGPG 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 559 AYSPQRGQQLPQASQQ--PGLQPMMSNQQQTAYQGMLGVQQPQNQGLLSNQRSSMGGQMQ---GLVVQYTPLPSYQVPVG 633
Cdd:pfam09606 282 QPMGPPGQQPGAMPNVmsIGDQNNYQQQQTRQQQQQQGGNHPAAHQQQMNQSVGQGGQVValgGLNHLETWNPGNFGGLG 361

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 634 SDSQNVVQP---SFQQPMLVPASQSVQG--GLPTGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSEQYQMPQSPSPCSPPQ 708
Cdd:pfam09606 362 ANPMQRGQPgmmSSPSPVPGQQVRQVTPnqFMRQSPQPSVPSPQGPGSQPPQSHPGGMIPSPALIPSPSPQMSQQPAQQR 441

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1720362323 709 MSQQYSGVSPSG-PGVVVMqlNVPNGPQAPQNPSMVQWSHCKY 750
Cdd:pfam09606 442 TIGQDSPGGSLNtPGQSAV--NSPLNPQEEQLYREKYRQLTKY 482
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
 172-228 3.67e-11

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 59.16  E-value: 3.67e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720362323 172 LLKLEQEILDFINDNNNQFKKFPQMTSYHRMLLHRVAAYFGMDHNVDQTG--KAVIINK 228
Cdd:cd02325     1 REEREEELEAFAKDAAGKSLELPPMNSYERKLIHDLAEYYGLKSESEGEGpnRRVVITK 59
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 170-228 1.05e-10

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 57.89  E-value: 1.05e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720362323 170 MMLLKLEQEILDFINDNNNQFKkFPQMTSYHRMLLHRVAAYFGMDHNV--DQTGKAVIINK 228
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLE-LPPMSSYERRIIHELAQKYGLESESegEEPNRRVVVYK 60
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 421-649 1.13e-07

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 55.81  E-value: 1.13e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 421 PALQPSPQPVQFSPSSCPQVLLPVSPPQQ-----------YNMAEDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQH 489
Cdd:pfam09770 107 PAARAAQSSAQPPASSLPQYQYASQQSQQpskpvrtgyekYKEPEPIPDLQVDASLWGVAPKKAAAPAPAPQPAAQPASL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 490 PQQASFIM------------ASAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQvsyyPPGQYPNSNQQYRPLSHP 557
Cdd:pfam09770 187 PAPSRKMMsleeveaamraqAKKPAQQPAPAPAQPPAAPPAQQAQQQQQFPPQIQQQQ----QPQQQPQQPQQHPGQGHP 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 558 VAYspqrgQQLPQASQQPGLQPMMSNQQQTAYQGMLGV-QQP----QNQGLLSNQRSSMGGQMQGlVVQYTPLPSYQVPV 632
Cdd:pfam09770 263 VTI-----LQRPQSPQPDPAQPSIQPQAQQFHQQPPPVpVQPtqilQNPNRLSAARVGYPQNPQP-GVQPAPAHQAHRQQ 336

                         250
                  ....*....|....*..
gi 1720362323 633 GSDSQNVVQPSFQQPML 649
Cdd:pfam09770 337 GSFGRQAPIITHPQQLA 353
PHA03379 PHA03379
EBNA-3A; Provisional
 419-798 3.47e-06

EBNA-3A; Provisional


Pssm-ID: 223066 [Multi-domain]  Cd Length: 935  Bit Score: 51.21  E-value: 3.47e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 419 PVPALQPSPQPVQFSPSSCPQVLLPVSPPQQYNMAEDLSNPFgqmSLSRQGSTEAADPSSALFQP--PLISQHPQQASFI 496
Cdd:PHA03379  447 PVHDLEPGPLHDQHSMAPCPVAQLPPGPLQDLEPGDQLPGVV---QDGRPACAPVPAPAGPIVRPweASLSQVPGVAFAP 523

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 497 MAS---AGQPLPTSNYSTSSHAPPtqqvLPPQGYMQPP------QQIQVSYYPPGQYPNSNQQYRPLshPVAYSPQRGQQ 567
Cdd:PHA03379  524 VMPqpmPVEPVPVPTVALERPVCP----APPLIAMQGPgetsgiVRVRERWRPAPWTPNPPRSPSQM--SVRDRLARLRA 597

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 568 LPQASQQP-GLQPMMSNQQQTayqgmlgvQQPQNQGLLSNQRSSMGGQMQGL--VVQYTPLPSYQVPvgSDSQNVVQPSF 644
Cdd:PHA03379  598 EAQPYQASvEVQPPQLTQVSP--------QQPMEYPLEPEQQMFPGSPFSQVadVMRAGGVPAMQPQ--YFDLPLQQPIS 667

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 645 QQPMLVPASQSVQGGLPTGGVPVYYSMIPPAQQ--NGTSPSVGFLQPPGS-------EQYQMPQSPSPCSPPQMSQQYSG 715
Cdd:PHA03379  668 QGAPLAPLRASMGPVPPVPATQPQYFDIPLTEPinQGASAAHFLPQQPMEgplvperWMFQGATLSQSVRPGVAQSQYFD 747

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 716 VSPSGPgvvvMQLNVPNGPQAPQNPSMVQWshckyysVEQRGQKPGDLYSPdGSPQANAQMGSSPVTSPTQSPAPSPVTS 795
Cdd:PHA03379  748 LPLTQP----INHGAPAAHFLHQPPMEGPW-------VPEQWMFQGAPPSQ-GTDVVQHQLDALGYVLHVLNHPGVPVSP 815


                  ...
gi 1720362323 796 LSN 798
Cdd:PHA03379  816 AVN 818
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 399-575 1.00e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 49.70  E-value: 1.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  399 PALPPTPQHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQVLLPVSPPQQYNMAEDLSNPFGQMSLSRQGSTEAADPSS 478
Cdd:PRK10263   336 PVEPVTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQP 415

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  479 AlfQPPLISQHPQQASFIMASAGQPlPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYPPGQYpnsnQQYRPLSHPV 558
Cdd:PRK10263   416 A--QQPYYAPAPEQPAQQPYYAPAP-EQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLY----QQPQPVEQQP 488

                          170
                   ....*....|....*..
gi 1720362323  559 AYSPQRGQQLPQASQQP 575
Cdd:PRK10263   489 VVEPEPVVEETKPARPP 505
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 392-792 6.28e-05

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.07  E-value: 6.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 392 QQQQQQLPALPPTPQHQPPlnnhmisqPVPALQPSPQPVQFSPSSCPQVLLPVSPP--QQYNMAEDLSNPFGQMSLSRQG 469
Cdd:pfam03154 170 QPPVLQAQSGAASPPSPPP--------PGTTQAATAGPTPSAPSVPPQGSPATSQPpnQTQSTAAPHTLIQQTPTLHPQR 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 470 STEAADPSSALFQPPLISQHPQQA--SFIMASAGQPLPTSNYSTSSHAPptqQVLPPQGYMQPPQQIQvSYYPPGQYPNS 547
Cdd:pfam03154 242 LPSPHPPLQPMTQPPPPSQVSPQPlpQPSLHGQMPPMPHSLQTGPSHMQ---HPVPPQPFPLTPQSSQ-SQVPPGPSPAA 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 548 NQQYRPLSHPVAYSPQRGQQLPQASQQPGLQPM-MSNQQQTAYQGMLGVQQPQNQGLLSNQRSSMGGQMQGLVvqytPLP 626
Cdd:pfam03154 318 PGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLsMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNL----PPP 393

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 627 SYQVPVGSDSQNVVQPSFQQPM-LVPASQSVQGglptggvpvyysmiPPAQQNGTSPSVGFlqPPGSEQYQMPQSPSPCS 705
Cdd:pfam03154 394 PALKPLSSLSTHHPPSAHPPPLqLMPQSQQLPP--------------PPAQPPVLTQSQSL--PPPAASHPPTSGLHQVP 457

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 706 PPQMSQQYSGVSPSGPGVVvmqlnVPNGPQAPQNPSMVQWSHCKYYSVEQRGQKPGDLYSP------DGSPQANAQMGSS 779
Cdd:pfam03154 458 SQSPFPQHPFVPGGPPPIT-----PPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSCPlppvqiKEEALDEAEEPES 532

                         410
                  ....*....|...
gi 1720362323 780 PvTSPTQSPAPSP 792
Cdd:pfam03154 533 P-PPPPRSPSPEP 544
PHA03247 PHA03247
large tegument protein UL36; Provisional
 307-569 7.08e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.24  E-value: 7.08e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  307 PRPWSS----TDSDGSVRSMRPPVTKASSfsgisilTRGDSIGSSKGGSAGRLSRPGMALGAPEVC---NQVTSPQSVRG 379
Cdd:PHA03247  2712 PHALVSatplPPGPAAARQASPALPAAPA-------PPAVPAGPATPGGPARPARPPTTAGPPAPAppaAPAAGPPRRLT 2784

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  380 LLPCTAQQQQQQQQQQQQLPALPPTPQHQPPLNNHMISQPVPALQPSPQPVQFSPSSCPQvllPVSPPQQYNMAEDLSNP 459
Cdd:PHA03247  2785 RPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG---PPPPSLPLGGSVAPGGD 2861

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  460 FGQMSLSRQGSTEAADPS----SALFQPPLisqHPQQASFIMASAGQPLPTSnySTSSHAPPTQQVLPPQGYMQPPQQIQ 535
Cdd:PHA03247  2862 VRRRPPSRSPAAKPAAPArppvRRLARPAV---SRSTESFALPPDQPERPPQ--PQAPPPPQPQPQPPPPPQPQPPPPPP 2936

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1720362323  536 VSYYPPGQyPNSNQQYRPLSHPVAYSPQRGQQLP 569
Cdd:PHA03247  2937 PRPQPPLA-PTTDPAGAGEPSGAVPQPWLGALVP 2969
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 476-627 8.83e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 46.62  E-value: 8.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  476 PSSALFQPPLI-SQHPQQasfimasagQPLPTSNYSTSSH-APPTQQVLPPQGYMQPPQQiqvsYYPPGQYPNSNQQYRP 553
Cdd:PRK10263   740 PHEPLFTPIVEpVQQPQQ---------PVAPQQQYQQPQQpVAPQPQYQQPQQPVAPQPQ----YQQPQQPVAPQPQYQQ 806

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720362323  554 LSHPVAYSPQRGQ-QLPQASQQPGLQPmmsnQQQTAyqgmlgvqqPQNQGLLSNQRSSMGGQMQGLVVQYTPLPS 627
Cdd:PRK10263   807 PQQPVAPQPQYQQpQQPVAPQPQYQQP----QQPVA---------PQPQDTLLHPLLMRNGDSRPLHKPTTPLPS 868
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 456-625 1.48e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.57  E-value: 1.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 456 LSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQASfimasAGQPLptsNYstsshaPPTQQVLPPQGYMQPPQQIQ 535
Cdd:TIGR01628 371 LQDQFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQQF-----NGQPL---GW------PRMSMMPTPMGPGGPLRPNG 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 536 VSYYPPGQYPNSNQQYRPLSHPVA---YSPQ-RGQQLPQASQQPGLQPMMSNQQQTAYQgMLGVQQPQnqgllsNQRSSM 611
Cdd:TIGR01628 437 LAPMNAVRAPSRNAQNAAQKPPMQpvmYPPNyQSLPLSQDLPQPQSTASQGGQNKKLAQ-VLASATPQ------MQKQVL 509

                         170
                  ....*....|....
gi 1720362323 612 GGQMQGLVVQYTPL 625
Cdd:TIGR01628 510 GERLFPLVEAIEPA 523
PHA03377 PHA03377
EBNA-3C; Provisional
 399-686 8.17e-04

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 43.50  E-value: 8.17e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  399 PALPPTPQHQPPLNNHMISQPVPALQpsPQPVQFSPSScpqvllPVSPPQQYNMAEDLS--NPFGQMSLSRQGSTEAADP 476
Cdd:PHA03377   672 PATQSTPPRPSWLPSVFVLPSVDAGR--AQPSEESHLS------SMSPTQPISHEEQPRyeDPDDPLDLSLHPDQAPPPS 743

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  477 SSALFQPPLISQHPQqasfimasagqplptSNYSTSSHAPPTQqvLPPQGYMQPP-QQIQVSYYPPGQYP-NSNQQYRPL 554
Cdd:PHA03377   744 HQAPYSGHEEPQAQQ---------------APYPGYWEPRPPQ--APYLGYQEPQaQGVQVSSYPGYAGPwGLRAQHPRY 806

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  555 SHPVAYSPQR----GQQLPQASQQPGLQPmmsnqqqtAYQGMLGVQQPQNQGLLSNQRSSMGGQMQGLVVQYTPLPsyQV 630
Cdd:PHA03377   807 RHSWAYWSQYpghgHPQGPWAPRPPHLPP--------QWDGSAGHGQDQVSQFPHLQSETGPPRLQLSQVPQLPYS--QT 876

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720362323  631 PVGSDSQNVVQPSFQQPMlvpasQSVQGGLPTGGVPVYYSMIPPAQQNGTS-PSVGF 686
Cdd:PHA03377   877 LVSSSAPSWSSPQPRAPI-----RPIPTRFPPPPMPLQDSMAVGCDSSGTAcPSMPF 928
G_path_suppress pfam15991
G-protein pathway suppressor; This family of proteins inhibits G-protein- and ...
 422-581 1.11e-03

G-protein pathway suppressor; This family of proteins inhibits G-protein- and mitogen-activated protein kinase-mediated signal transduction.


Pssm-ID: 464961 [Multi-domain]  Cd Length: 272  Bit Score: 42.22  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 422 ALQPSPQPVQFSPSS-CPQVLLPVSPPQQYNMAEDLSNPFGQMSLSRQGSTEAADPSSALFQPPLISQHPQQASFIMASA 500
Cdd:pfam15991 103 ALQQAAAQVFLPQLSmQGQPHHQQHPGPQVGVLKRTRSPSPPVQQQAYYKQPAFSPGYAEHGQQKHDDGRRGYDVARFGS 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 501 GQPLPTSNYSTSSHAPPTQQVLPP-QGYMQPPQQIQVSYYPPGQYPNSNQQYRPLSHPVAY---SPQRGQQLPQA--SQQ 574
Cdd:pfam15991 183 WNKSTAQYPPSGQLFYPTHQYLPPpQTQGQADARLQTIYPQPGYALPLQQQYEHANQPSPFvssSPLKQMQSPKAgpGPQ 262


                  ....*..
gi 1720362323 575 PGLQPMM 581
Cdd:pfam15991 263 PMQLSVL 269
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 470-669 1.96e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 42.38  E-value: 1.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  470 STEAADPSSALFQPPLISQHPQqasfimaSAGQPLPTSNYSTSSHAPPtqqvlpPQGYMQPPQ--QIQVSYYPPGQYPNS 547
Cdd:PRK10263   336 PVEPVTQTPPVASVDVPPAQPT-------VAWQPVPGPQTGEPVIAPA------PEGYPQQSQyaQPAVQYNEPLQQPVQ 402

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  548 NQQyrPLSHPVAYSPQRGQQLPQASQQPGLQPMMSNQQQTAYQGMLGVQQPQNQgLLSNQRSsmggqmqglvvqYTPLPS 627
Cdd:PRK10263   403 PQQ--PYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQS-TFAPQST------------YQTEQT 467

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1720362323  628 YQVPVGSDSQNVVQPSFQQPMLVPASQSVQGGLPTGGvPVYY 669
Cdd:PRK10263   468 YQQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARP-PLYY 508
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
 563-693 3.67e-03

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 40.95  E-value: 3.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 563 QRGQQLPQASQQPGLQPMMSNQQQTAYQGMLGVQQ----PQNQGLLSNQRSSMGGQMQGLVVQYTPLPSYQVPvGSDSQN 638
Cdd:TIGR01628 374 QFMQLQPRMRQLPMGSPMGGAMGQPPYYGQGPQQQfngqPLGWPRMSMMPTPMGPGGPLRPNGLAPMNAVRAP-SRNAQN 452

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720362323 639 VVQPSFQQPMlvPASQSVQGGLPTGGVPVYYSMIPPAQQNGTSPSVGFLQPPGSE 693
Cdd:TIGR01628 453 AAQKPPMQPV--MYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQMQ 505
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 306-693 3.95e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 3.95e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  306 EPRPWSSTDSDGSVRSMrPPVTKASSfsgISILTRGDSIGSSKGGSAGRLSRPGMAL---GAPEvcnqvtsPQSVRGLLP 382
Cdd:PRK10263   536 EPEPIKSSLKAPSVAAV-PPVEAAAA---VSPLASGVKKATLATGAAATVAAPVFSLansGGPR-------PQVKEGIGP 604

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  383 ctaqqqqqqqqqqqqlpALPPTPQHQPPLNNHMISQPV--PALQPSPQPVQFSPSSCPQVLLPVSPPQQYNMAED-LSNP 459
Cdd:PRK10263   605 -----------------QLPRPKRIRVPTRRELASYGIklPSQRAAEEKAREAQRNQYDSGDQYNDDEIDAMQQDeLARQ 667

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  460 FGQMSLSRQGST-------EAADPSSALfQPPLISQ--HPQQASFimaSAGQPLPTSNYSTSSHAPPTQQVLPPQGYMQP 530
Cdd:PRK10263   668 FAQTQQQRYGEQyqhdvpvNAEDADAAA-EAELARQfaQTQQQRY---SGEQPAGANPFSLDDFEFSPMKALLDDGPHEP 743

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  531 pqqiqvsYYPPGQYPNSNQQYRPLSHPVAYSPQRgqqlPQASQQPGLQPMMSNQQQTAYQGMLGVQQPQNQGLLSNQrss 610
Cdd:PRK10263   744 -------LFTPIVEPVQQPQQPVAPQQQYQQPQQ----PVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQ--- 809

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  611 mggqmqglvvQYTPLPSYQVPvgsDSQNVVQPSFQQPMLVPASQSVQgglptggvpvyySMIPP-AQQNGTS-------- 681
Cdd:PRK10263   810 ----------PVAPQPQYQQP---QQPVAPQPQYQQPQQPVAPQPQD------------TLLHPlLMRNGDSrplhkptt 864

                          410
                   ....*....|....
gi 1720362323  682 --PSVGFLQPPGSE 693
Cdd:PRK10263   865 plPSLDLLTPPPSE 878
PRK14948 PRK14948
DNA polymerase III subunit gamma/tau;
362-575 5.66e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237862 [Multi-domain]  Cd Length: 620  Bit Score: 40.72  E-value: 5.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 362 LGAPEVCNQVTSPQSVRGLLPCTAQQQQQQQQQQQQLPALPPTPQHQPPLNN-HMISQPVPALQPSPQPVQfspsscpqv 440
Cdd:PRK14948  360 LPSAFISEIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKAsPPIPVPAEPTEPSPTPPA--------- 430

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 441 lLPVSPPQQYNMAE-------DLSNPFGQMSLSRQGSTEAADPSSALFQ------------PPLIS-------QHPQQAS 494
Cdd:PRK14948  431 -NAANAPPSLNLEElwqqilaKLELPSTRMLLSQQAELVSLDSNRAVIAvspnwlgmvqsrKPLLEqafakvlGRSIKLN 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 495 FIMASAGQPlptsnySTSSHAPPTQQVLPPQGYMQPPQQIQVSYYPPGQYPNSNQQYRPLSHPVAYSPQRGQQLPQASQQ 574
Cdd:PRK14948  510 LESQSGSAS------NTAKTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPPPPPTATQASSNAPAQIPADSSPPPPIPEE 583


                  .
gi 1720362323 575 P 575
Cdd:PRK14948  584 P 584
Amelin smart00817
Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin ...
 467-602 5.77e-03

Ameloblastin precursor (Amelin); This family consists of several mammalian Ameloblastin precursor (Amelin) proteins. Matrix proteins of tooth enamel consist mainly of amelogenin but also of non-amelogenin proteins, which, although their volumetric percentage is low, have an important role in enamel mineralisation. One of the non-amelogenin proteins is ameloblastin, also known as amelin and sheathlin. Ameloblastin (AMBN) is one of the enamel sheath proteins which is though to have a role in determining the prismatic structure of growing enamel crystals.


Pssm-ID: 214832 [Multi-domain]  Cd Length: 411  Bit Score: 40.26  E-value: 5.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323  467 RQGSTEAADPSSALFQPPLISQHPQQAsfimasagqPLPTSNYSTSSHAPPTQQVLPPQGYMQPPQQIQVSYYPPGQYPN 546
Cdd:smart00817  82 REHETQQYEYSLPVHPPPLPSQPSLQP---------QQPGLKPFLQPTALPTNQATPQKNGPQPPMHLGQPPLQQAELPM 152

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720362323  547 SNQQYRPLSHP-------VAYSPQRGQQLPQASQQPGLQPMMSNQQQTAYQGMLGVQQPQNQG 602
Cdd:smart00817 153 IPPQVAPSDKPpqtelplYDFADPQNPLLFQIAHLMSRGPMPQNKQQHLYPGLFYMSYGANQL 215
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 462-690 6.87e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.40  E-value: 6.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 462 QMSLSRQGSTEAADPSSALfQPPLISQHPQQASFIMASAGQPLPTS--NYSTSSHAPPTQ--QVL---PPQGYMQPPQQI 534
Cdd:pfam09770  99 QVRFNRQQPAARAAQSSAQ-PPASSLPQYQYASQQSQQPSKPVRTGyeKYKEPEPIPDLQvdASLwgvAPKKAAAPAPAP 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 535 QVSYYPPGQYPNSNQ---------QYRplshpvAYSPQRGQQLPQASQQP--GLQPMMSNQQQTAYQGMLGVQQPQNQGL 603
Cdd:pfam09770 178 QPAAQPASLPAPSRKmmsleeveaAMR------AQAKKPAQQPAPAPAQPpaAPPAQQAQQQQQFPPQIQQQQQPQQQPQ 251

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362323 604 LSNQRSSMGGQMQGL---------VVQYTPLPSYQVPVGSDSQNVVQPS--FQQPMLVPASQSVQGGLPTGGVPVyysmi 672
Cdd:pfam09770 252 QPQQHPGQGHPVTILqrpqspqpdPAQPSIQPQAQQFHQQPPPVPVQPTqiLQNPNRLSAARVGYPQNPQPGVQP----- 326

                         250
                  ....*....|....*...
gi 1720362323 673 PPAQQNGTSPSVGFLQPP 690
Cdd:pfam09770 327 APAHQAHRQQGSFGRQAP 344
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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