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Conserved domains on  [gi|1720362617|ref|XP_030101215|]
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MFS-type transporter SLC18B1 isoform X1 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-295 3.99e-132

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17385:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 390  Bit Score: 381.57  E-value: 3.99e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   1 MCFLVRIVDAIGFGAAITASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPL 80
Cdd:cd17385    96 LCFLVRIVEAVGFAAFITASFAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPL 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  81 NLYILPSYESDPGKQ--SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVmEKFSLSTGYVGLVFLGLSLSYAISSP 158
Cdd:cd17385   176 NMFILPRYDDDPSPKsgSMLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHL-RQFKLSPGQVGLMFLILAGSYAISAP 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 159 LFGLLSDKMPtLRKWLLVFGNLITAGCYMLLGPVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDS 238
Cdd:cd17385   255 LWGWLSDKKK-IPKWLMVIGSIITGVGFLLLGPAPLLPIKSELWMVIIGLVLLGLSLGAALVPTFPELLNCAREYGFPDN 333

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720362617 239 ISTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALFY 295
Cdd:cd17385   334 LSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSIYY 390
 
Name Accession Description Interval E-value
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 1-295 3.99e-132

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 381.57  E-value: 3.99e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   1 MCFLVRIVDAIGFGAAITASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPL 80
Cdd:cd17385    96 LCFLVRIVEAVGFAAFITASFAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPL 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  81 NLYILPSYESDPGKQ--SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVmEKFSLSTGYVGLVFLGLSLSYAISSP 158
Cdd:cd17385   176 NMFILPRYDDDPSPKsgSMLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHL-RQFKLSPGQVGLMFLILAGSYAISAP 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 159 LFGLLSDKMPtLRKWLLVFGNLITAGCYMLLGPVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDS 238
Cdd:cd17385   255 LWGWLSDKKK-IPKWLMVIGSIITGVGFLLLGPAPLLPIKSELWMVIIGLVLLGLSLGAALVPTFPELLNCAREYGFPDN 333

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720362617 239 ISTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALFY 295
Cdd:cd17385   334 LSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSIYY 390
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-257 3.08e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.09  E-value: 3.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   3 FLVRIVDAIGFGAAITASSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLN 81
Cdd:COG2814   102 LAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  82 LYILPSY---ESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSP 158
Cdd:COG2814   182 LRLLPESrpaARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGAL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 159 LFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAyangfedS 238
Cdd:COG2814   262 LAGRLADRFG--RRRLLLIGLLLLALGLLLLALAG------SLWLLLLALFLLGFGFGLLFPLLQALVAELA-------P 326

                         250
                  ....*....|....*....
gi 1720362617 239 ISTLGLVSGLFGAMWSVGA 257
Cdd:COG2814   327 PEARGRASGLYNSAFFLGG 345
MFS_1 pfam07690
Major Facilitator Superfamily;
3-261 5.82e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 65.52  E-value: 5.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   3 FLVRIVDAIGFGAAITASSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLN 81
Cdd:pfam07690  89 LVLRVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  82 LYILPSYESDPGKQ---------SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFvMEKFSLSTGYVGLVFLGLSLS 152
Cdd:pfam07690 169 LLPRPPPESKRPKPaeearlsliVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLL 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 153 YAISSPLFGLLSDKMPTLRKWLLVFGNLITAGCYMLLgpvpLLHIKSQLWLLVLVlvvngISAGMSIIPTFPEMLSCAYA 232
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL----LSLTLSSLWLLLAL-----LLLGFGFGLVFPALNALVSD 318

                         250       260
                  ....*....|....*....|....*....
gi 1720362617 233 NGFEDSIstlGLVSGLFGAMWSVGAFMGP 261
Cdd:pfam07690 319 LAPKEER---GTASGLYNTAGSLGGALGP 344
PRK03545 PRK03545
putative arabinose transporter; Provisional
 16-192 4.67e-03

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 38.33  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  16 AITASSSILAkAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYESDpGKQ 95
Cdd:PRK03545  116 SITASLAIRV-APAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGALITLLLLIKLLPLLPSE-HSG 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  96 SFWKLVTLPK----MGLLAFVIISLS---SCFGFLDPtlslFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMP 168
Cdd:PRK03545  194 SLKSLPLLFRrpalVSLYLLTVVVVTahfTAYSYIEP----FVQQVAGLSENFATLLLLLFGGAGIIGSVLFSRLGNRHP 269

                         170       180
                  ....*....|....*....|....
gi 1720362617 169 TLrkwLLVFGNLITAGCYMLLGPV 192
Cdd:PRK03545  270 SG---FLLIAIALLLVCLLLLLPA 290
 
Name Accession Description Interval E-value
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 1-295 3.99e-132

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 381.57  E-value: 3.99e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   1 MCFLVRIVDAIGFGAAITASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPL 80
Cdd:cd17385    96 LCFLVRIVEAVGFAAFITASFAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPL 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  81 NLYILPSYESDPGKQ--SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVmEKFSLSTGYVGLVFLGLSLSYAISSP 158
Cdd:cd17385   176 NMFILPRYDDDPSPKsgSMLKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHL-RQFKLSPGQVGLMFLILAGSYAISAP 254

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 159 LFGLLSDKMPtLRKWLLVFGNLITAGCYMLLGPVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDS 238
Cdd:cd17385   255 LWGWLSDKKK-IPKWLMVIGSIITGVGFLLLGPAPLLPIKSELWMVIIGLVLLGLSLGAALVPTFPELLNCAREYGFPDN 333

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720362617 239 ISTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALFY 295
Cdd:cd17385   334 LSTYGLVSGLFNAAFSLGAFIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSIYY 390
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 1-295 1.20e-37

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 137.71  E-value: 1.20e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   1 MCFLVRIVDAIGFGAAITASSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIP 79
Cdd:cd17325    86 QLLLARFLQGLASAAVWPAAMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALV 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  80 LNLYILP---------SYESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLS 150
Cdd:cd17325   166 LALLLLPeprpppnkrAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQG 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 151 LSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCA 230
Cdd:cd17325   246 LASALSQPPAGKLSDRIG--RKPLILIGLLLSAVALLLLPLAT------SFWLLLLLLALLGLGLGLVFPATLALLADIV 317

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720362617 231 YANGfedsistLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALFY 295
Cdd:cd17325   318 PPEG-------RGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 3-275 7.00e-18

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 83.39  E-value: 7.00e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   3 FLVRIVDAIGFGAAITASSSILAKAFPNN------VATVMGSLevfsGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLL 76
Cdd:cd17384    88 FLARALQGVGSACSSVAGMGMLASLYPDDkergkaMGIALGGL----ALGVLVGPPFGGVMYEFVGKSAPFLILAFLALL 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  77 MIPLNLYILP---SYESDPGKQSFWKLVTLPKMgLLAFVIISLS-SCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLS 152
Cdd:cd17384   164 DGALQLFILQpsvKSEESEEGTPWKTLLKDPYI-LIAAGAICFSnSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIG 242

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 153 YAISSPLFGLLSDKMptlRKWLLVFGNLITAGCYMLLgpVPLLHIKSQLWLLVLVLvvnGISAGMSIIPTFPEMLSCAYA 232
Cdd:cd17384   243 YLIGTNLFGPLAHKI---GRWLCSLLGMLLVGISLIL--IPLAKNIYGLIIPHFGL---GLGIGMVDSSMMPLLAYLVDL 314

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1720362617 233 NGfedsISTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEW 275
Cdd:cd17384   315 RH----SSVYGSVYAIADVAFCLAFALGPSLGGAIVKSIGFPW 353
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-257 3.08e-16

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 78.09  E-value: 3.08e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   3 FLVRIVDAIGFGAAITASSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLN 81
Cdd:COG2814   102 LAARFLQGLGAGALFPAALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLL 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  82 LYILPSY---ESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSP 158
Cdd:COG2814   182 LRLLPESrpaARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGAL 261

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 159 LFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAyangfedS 238
Cdd:COG2814   262 LAGRLADRFG--RRRLLLIGLLLLALGLLLLALAG------SLWLLLLALFLLGFGFGLLFPLLQALVAELA-------P 326

                         250
                  ....*....|....*....
gi 1720362617 239 ISTLGLVSGLFGAMWSVGA 257
Cdd:COG2814   327 PEARGRASGLYNSAFFLGG 345
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
3-294 1.37e-14

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 73.37  E-value: 1.37e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   3 FLVRIVDAIGFGAAITASSSILAKAFPNNV-ATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLN 81
Cdd:COG2271   102 LLLRFLLGLGEAGFFPAALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLR 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  82 LYilpsyesdpgkqsfwklvtlpkmgLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFG 161
Cdd:COG2271   182 FW------------------------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGG 237

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 162 LLSDKMPTLRKWLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAyangfedSIST 241
Cdd:COG2271   238 WLSDRLGRRRKLVLAIGLLLAALALLLLALLP------SPALAIALLFLAGFGLGGAFGLLWALAAELF-------PKKA 304

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720362617 242 LGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALF 294
Cdd:COG2271   305 RGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 4-289 3.75e-13

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 69.52  E-value: 3.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   4 LVRIVDAIGFGAAITASSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLyQSFGYEVPFIFLGCIVLLMIPLNL 82
Cdd:cd17474    92 AGRALQGIGAAGLGPLALTLIGDLFEgGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAIL 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  83 YILPSYESDPGKQSFWKLVTLPKM----GLLAFVIISLSSCFGF--LDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAIS 156
Cdd:cd17474   171 FLLPEPKEKAKSSSATKLRDLKKAlrgrGLLTFLVSAFLYFFLYfaFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALG 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 157 SPLFGLLSdKMPTLRKWLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSiIPTFPEMLscayANGFE 236
Cdd:cd17474   251 SLFVGRLL-KKRFGARRILVIGLLLYALSLLLLGFVP------SLALLLIAIVLFGLGLGLN-LPLLTTLV----TELAP 318

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720362617 237 DSIstLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGV 289
Cdd:cd17474   319 EEE--RGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 1-295 4.14e-12

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 66.09  E-value: 4.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   1 MCFLVRIVDaiGFGAAITASSSILAKAF--PNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMI 78
Cdd:cd17490    87 GLLIARFLS--GIAAATWVSFTVLYASYfpPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGF 164

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  79 PLNLYILPSYESD----PGKQSFWKLVTLPKM---GLLAFV--IISLSSCFGFLDPTLSLFVMEKFSLstgyvGLVFLGL 149
Cdd:cd17490   165 ILSLFIKEERREKkpvlTELKELLSVLKDKKLlffSLLAILqqMITFSTTFGFTPLIAKQLGASSFQL-----GLLSIIY 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 150 SLSYAISSPLFGLLSDKMPTLRKWLLvFGNLITAGCYMLlgpVPLLhikSQLWLLVLVLVVNGISAGMsiipTFPEMLSC 229
Cdd:cd17490   240 LLPNALASLLSGTLFYKKLGERNTII-IGFLLLGAYCFL---IPFA---PNLTLLYLLQALNGFGTGI----LFPLLMSL 308

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720362617 230 AYANGFEDSISTlglVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALFY 295
Cdd:cd17490   309 SIEGVPAEQRST---AMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
11-295 5.54e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 66.06  E-value: 5.54e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  11 IGFGAAITASSSI--LAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYIL-- 85
Cdd:COG2223   103 LGIGGGGSFAVGIalVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLrd 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  86 -PSYESDPGKQSF---WKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFG 161
Cdd:COG2223   183 pPAGAAAAAKASLrdqLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGG 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 162 LLSDKMPtLRKWLLVFGNLITAGCymllgpVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMlscayanGFEDSIST 241
Cdd:COG2223   263 WLSDRIG-GRRVLLIVFALMALGL------LLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV-------PDIFPTKN 328

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720362617 242 LGLVSGLFGAMWSVGAFMGPILGGFLCEKIG-FEWAAAMQGLWTLLSGVSMALFY 295
Cdd:COG2223   329 AGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLY 383
MFS_1 pfam07690
Major Facilitator Superfamily;
3-261 5.82e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 65.52  E-value: 5.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   3 FLVRIVDAIGFGAAITASSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLN 81
Cdd:pfam07690  89 LVLRVLQGLGAGALFPAALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  82 LYILPSYESDPGKQ---------SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFvMEKFSLSTGYVGLVFLGLSLS 152
Cdd:pfam07690 169 LLPRPPPESKRPKPaeearlsliVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLL 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 153 YAISSPLFGLLSDKMPTLRKWLLVFGNLITAGCYMLLgpvpLLHIKSQLWLLVLVlvvngISAGMSIIPTFPEMLSCAYA 232
Cdd:pfam07690 248 GAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL----LSLTLSSLWLLLAL-----LLLGFGFGLVFPALNALVSD 318

                         250       260
                  ....*....|....*....|....*....
gi 1720362617 233 NGFEDSIstlGLVSGLFGAMWSVGAFMGP 261
Cdd:pfam07690 319 LAPKEER---GTASGLYNTAGSLGGALGP 344
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 3-294 2.42e-11

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 63.77  E-value: 2.42e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   3 FLVRIVDAIGFGAAITASSSILAKAFPN-NVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLN 81
Cdd:cd17489    88 LVLRLIHGIGWGAFTTAAATLVADIIPPsRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLV 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  82 LYI----LPSYESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSlstGYVGLVFLGLSLSYAISS 157
Cdd:cd17489   168 FLVkdppPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI---SNAGLFFTVYAIALLLSR 244

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 158 PLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSiiptFPEMLSCAYANGFED 237
Cdd:cd17489   245 PFSGKLSDRKG--PKTVIIPGLLLLALGLLLLSFAG------SPWMLLLAAVLYGLGFGLL----FPALQALAVDLVPPH 312

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720362617 238 SIstlGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALF 294
Cdd:cd17489   313 RR---GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 1-197 4.81e-09

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 56.82  E-value: 4.81e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   1 MCFLVRIVDAIGFGAAITASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIpl 80
Cdd:cd17330    89 LLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNL-- 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  81 nLYIlpsyesdpgkqsfwkLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLF 160
Cdd:cd17330   167 -VLV---------------LFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLL 230

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1720362617 161 GLLSDKMPTLRKwLLVFGNLITAGCYMLLGPVPLLHI 197
Cdd:cd17330   231 IPRLAKRLGERK-LLRLGLLLAIIGLLLLPFASSVPL 266
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
33-294 7.05e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.45  E-value: 7.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  33 ATVMGSLEVFSGLGLVAGPPLGGLLYQSF------GYEVPFIFLGCIVLLMIPLNL-----YILPSYESDPGKQSFWKLV 101
Cdd:COG2211   146 TRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFfgtkeRPVPEEEKVSLKESLKALL 225

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 102 TLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLI 181
Cdd:COG2211   226 KNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG--KKKAFIIGLLL 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 182 TAGCYMLLGPVPllhiKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGAFMGP 261
Cdd:COG2211   304 AALGLLLLFFLG----PGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAG 379

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1720362617 262 ILGGFLCEKIGFEWAA-----AMQGLWTLLSGVSMALF 294
Cdd:COG2211   380 ALAGLLLALFGYVAGAaqspsALTGIRLLFFLLPAVLL 417
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 3-287 1.37e-08

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 55.63  E-value: 1.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   3 FLVRIVDAIGFGAAITASSSILAKAFP-NNVATVMGSleVFSGL--GLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIP 79
Cdd:cd17324    91 LLARALAGLAHGGFWAIAAAYAADLVPpEKRGRAIGL--VFSGLtlGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAAL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  80 LNLYILPSYESDPGKQ-----SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYA 154
Cdd:cd17324   169 LLWRLLPSLPPKKPGSlgllsSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGV 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 155 ISSPLFGLLSDKMPTLRkwlLVFGNLITAGCYMLLGPVPllhikSQLWLLVLVLVVNGISAGMsiiptfpeMLSCAYANG 234
Cdd:cd17324   249 VGSPLAGRLADRGGRRA---LLIALLLLAAALLLLTLLG-----PSPLLLLVGLVLWGLGFFA--------AHSALQTRV 312

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720362617 235 FEDSISTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLS 287
Cdd:cd17324   313 LRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLA 365
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 45-289 3.44e-08

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 54.47  E-value: 3.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  45 LGLVAGPPLGGLL--YQSFGYEVPFIFLGCIVLLMIPLNLYILPSYE--SDPGKQSFWKLVTLPKMGLLAFVIISLSSCF 120
Cdd:cd17370   135 LGAVLGPLLAALLlyLLGGNYRTIFLLAAIPALLALLILLFVVKEYPrpPKLRKKSKKTSLKKLPKAFWLYLLAVALFAL 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 121 GFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGpvpllhIKSQ 200
Cdd:cd17370   215 GNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIG--RKKLLILGYLSLALAYLGFA------LGSS 286

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 201 LWLLVLVLVVNGISAGMSiiptfpEMLSCAYANGFEDSiSTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQ 280
Cdd:cd17370   287 LWLLLLGFILWGLYMGAQ------ESIERAAVADLVPA-ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFS 359


                  ....*....
gi 1720362617 281 GLWTLLSGV 289
Cdd:cd17370   360 AVLALIALL 368
MFS_1 pfam07690
Major Facilitator Superfamily;
109-309 7.11e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.19  E-value: 7.11e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 109 LAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYML 188
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG--RRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 189 LGPVpllhikSQLWLLVLVLVVNGISAGMSIIPTFPemLSCAYANGFEdsistLGLVSGLFGAMWSVGAFMGPILGGFLC 268
Cdd:pfam07690  79 LLFA------SSLWLLLVLRVLQGLGAGALFPAALA--LIADWFPPEE-----RGRALGLVSAGFGLGAALGPLLGGLLA 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1720362617 269 EKIGFEWAAAMQGLWTLLSGVsmaLFYLWEDSTARRRSKAQ 309
Cdd:pfam07690 146 SLFGWRAAFLILAILSLLAAV---LLLLPRPPPESKRPKPA 183
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 3-272 2.93e-07

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 51.41  E-value: 2.93e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   3 FLVRIVDAIGFGAAITAS-SSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSfGYeVPFIFLGCIVLL-MIPL 80
Cdd:cd17477    88 FLLRFVMGIGLAGLFVVSeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GA-LPFLIAAVLLLLaLVPL 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  81 NLYILPSYESD-PGKQSFWKLVTLPKMGLLAFVI--ISLSSCFGFLdptlSLFVMEKfSLSTGYVGLVFLGLSLSYAISS 157
Cdd:cd17477   166 LLTRRAAPEIEeAESISLRRLLRIAPLALLGAFVagFLEGAFYSLL----PLYGLRL-GLSVAQAALLLAAFVLGGLLLQ 240

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 158 PLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPLLHIksQLWLLVLVlvvngisAGMSIIPTFPemLSCAYANGFED 237
Cdd:cd17477   241 WPLGWLADRFD--RRRVLLGCALLGALAALLLPLVPGLPL--ALLVLLFL-------WGGAAGPLYT--LALALAGDRLP 307

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1720362617 238 SiSTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIG 272
Cdd:cd17477   308 G-DELVAANAALLLLYGLGSVIGPLLAGALMDAFG 341
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 109-323 6.50e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 50.27  E-value: 6.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 109 LAFVIISLSSCFGFLDPTLSLFvMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMptLRKWLLVFGNLITAGCYML 188
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRF--GRKRLLLLGLLLLAVSTLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 189 LGpvpllhIKSQLWLLVLVLVVNGISAGMsIIPTFPEMLSCAYANGfedsisTLGLVSGLFGAMWSVGAFMGPILGGFLC 268
Cdd:cd17325    78 FA------FATSYWQLLLARFLQGLASAA-VWPAAMALIADIAPPE------ERGRAMGIFSSAIGLGFLIGPLLGGLLA 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1720362617 269 EKIGFEWAAAMQGLWTLLSGVsMALFYLWEDSTARRRSKAQNSLGTEEERAALLP 323
Cdd:cd17325   145 DALGYRAPFLVCAALALLALV-LALLLLPEPRPPPNKRAVSAARLRSGLRLLLRD 198
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
 3-286 1.02e-06

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 49.62  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   3 FLVRIVDAIGFGAAITASSSILAKAFP--NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPL 80
Cdd:cd17383    87 FFARSLQGVGSAFADTAGLAMIADRFTeeAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLL 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  81 NLYILPSYE-------SDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSY 153
Cdd:cd17383   167 LLLVMKPVRretranmPEPVGTPIHRLLMDPYIAVCAGALTMANVSLAFLEPTIANWMKDTMNASEWQMGLVWLPAFFPH 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 154 AISSPLFGLLSDKMPTLRKWLLVFGNLITAGCYMLlgpVPLLHIKSQLwllvlVLVVNGISAGM-----SIIPTFPEMLS 228
Cdd:cd17383   247 VLGVYLTVKLAAKYPHYQWLMAAVGLAIEGASCFI---VPFCTNFGVL-----IIPLCGICFGIalvdtALLPTLGFLVD 318

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720362617 229 CAYangfedsISTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLL 286
Cdd:cd17383   319 VRH-------VSVYGSVYAIADISYSLAYALGPIVAGQIVHSIGFTQLNIGIGLANLL 369
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 6-280 3.58e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 47.94  E-value: 3.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   6 RIVDAIGFGAAITASSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLnlyi 84
Cdd:cd17321    91 RALQGIGAAAIMPASLALIAATFPgERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL---- 166

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  85 lpsyesdpgkqsfwklvtLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLS 164
Cdd:cd17321   167 ------------------ARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLA 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 165 DKMPTlrKWLLVFGNLITA-GCYMLLgpvpLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANgfedsisTLG 243
Cdd:cd17321   229 DRFGP--RLVLVAGLLLTAvGLLLLA----LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKE-------KAG 295

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720362617 244 LVSGLFGAMWSVG-----AFMGPILGGFLCEKIGFEWAAAMQ 280
Cdd:cd17321   296 AASGILNTARQLGgalgvALLGALLTAGLSANLGDSGVAALL 337
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
106-310 4.95e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.66  E-value: 4.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 106 MGLLAFVIISLSSCFGFLDPTLSLFvMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGC 185
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG--RRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 186 YMLLGPVPllhiksQLWLLVLVLVVNGISAGMsIIPTFPEMLSCAYANGfedsisTLGLVSGLFGAMWSVGAFMGPILGG 265
Cdd:COG2814    89 SLLCALAP------SLWLLLAARFLQGLGAGA-LFPAALALIADLVPPE------RRGRALGLLGAGLGLGPALGPLLGG 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1720362617 266 FLCEKIGFEWAAAMQGLWTLLSGVsMALFYLWEDSTARRRSKAQN 310
Cdd:COG2814   156 LLADLFGWRWVFLVNAVLALLALL-LLLRLLPESRPAARARLRGS 199
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 108-314 1.34e-05

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 46.39  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 108 LLAFVIISLSscFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTlRKWLLVFGNLITAGCYM 187
Cdd:cd17471     2 LLATLLTGLA--GAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGD-RKPLILLALLAGALGYL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 188 LLGpvpllHIKSQLWLLVLVLVVNGISAgmsiiPTFPEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGAFMGPILGGFL 267
Cdd:cd17471    79 LFA-----FLRNYWVLLLVGVVLLSLGA-----AAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLL 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1720362617 268 CEKIGFEWAAAMQGLWTLLSGVsMALFYLWEDSTARRRSKAQNSLGT 314
Cdd:cd17471   149 LDVLGFTGLFLLAALLYLVVAL-LVLFLLPSVKPPAQKATPASSLVK 194
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
10-276 2.24e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.62  E-value: 2.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  10 AIGFGAAITASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQ---SFGYEVPFIFLGCIVLLMI------PL 80
Cdd:COG0738   107 GLGLGLLDVAANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLAllflrsKL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  81 NLYILPSYESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLF 160
Cdd:COG0738   187 PEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLG 266

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 161 GLLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPllhiksqlWLLVLVLVVNGISAGMSIIptFPEMLSCAYANGFEDSIS 240
Cdd:COG0738   267 GFLLKRFG--PVRLLRLSALLAAVGLLLALLAP--------GPWLALIGLALVGLGLSLM--FPTIFSLALDGLGKRTAA 334

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1720362617 241 TLGLVSglfgAMWSVGAFMGPILGGFLCEKIGFEWA 276
Cdd:COG0738   335 AVSAVL----IMGIVGGAIGPPLIGFLADAFGLRAA 366
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 3-293 2.50e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 45.25  E-value: 2.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   3 FLVRIVDAIGFGAAITASSSILAKAFPNNV-ATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMipln 81
Cdd:cd17319    95 YVLRFLLGVAEAGFFPGAIKALAEWFPARErGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLL---- 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  82 lyilpsyesdpgkqSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFG 161
Cdd:cd17319   171 --------------AVLWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGG 236

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 162 LLSDKMPTL-RKWLLVFGNLITAGCYMLLGPVpllhikSQLWLLVLVLVVNGISAGMSIIPTFPemLSCAYANGfedsiS 240
Cdd:cd17319   237 RLSDRLLRGaRRLVIIIGLLLAAVGLLLAYLT------TSPVVAVILLSLAGFGIGAASPVFWS--LPADLLPG-----E 303

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720362617 241 TLGLVSGLFGAMWSVGAFMGPILGGFLCEKIG-FEWAAAMQGLWTLLSGVSMAL 293
Cdd:cd17319   304 AAATAGGLINSGGNLGGFVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLVLL 357
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 29-189 5.43e-05

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 44.46  E-value: 5.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  29 PNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYESDPGK----QSFWKLVTLP 104
Cdd:cd17471   120 GRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKatpaSSLVKAPVNR 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 105 KMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFlglSLSYAISSP---LFGLLSDKMPtlRKWLLVFGNLI 181
Cdd:cd17471   200 RLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLF---GLAAALEIPimlLAGLLAKRFG--KRRLLLAGFLA 274


                  ....*...
gi 1720362617 182 TAGCYMLL 189
Cdd:cd17471   275 GVLFYLGL 282
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 121-314 8.12e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 43.70  E-value: 8.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 121 GFLDPTLSLFVmEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPllhiksQ 200
Cdd:cd17478    13 GFLPALLPLLI-AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKP--RRYLLPLGPLLTGLGLSLLGFAP------N 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 201 LWLLVLVLVVNGISAGMsiiptF-PEmlSCAYANGFEDSISTLGLvsGLFGAMWSVGAFMGPILGGFLCEKigfeWAAAM 279
Cdd:cd17478    84 YWLLLLLVALAGIGSAA-----FhPE--GARLASQAAGGRRGLAM--SIFSVGGNLGFALGPLIAAALVAL----FGGLG 150

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1720362617 280 QGLWTLLSGVSMALFYLWEDSTARRRSKAQNSLGT 314
Cdd:cd17478   151 LLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSS 185
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 1-267 8.85e-05

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 43.95  E-value: 8.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   1 MCFLVRIVDAIGFGAAITASSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQ--SFGYEVPFIFLGCIVLLM 77
Cdd:cd06174    86 LLLLGRFLLGLGSGLIDPAVLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLA 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  78 IPLNLYILPSYESDPGKQ-----------SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVF 146
Cdd:cd06174   166 AILLLLVVPDPPESARAKneeassksvlkLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLL 245

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 147 LGLSLSYAISSPLFGLLSDKMPTLRKWLLVFGNLITAGC-YMLLGPVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPE 225
Cdd:cd06174   246 SLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLaLLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPE 325

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1720362617 226 MlscayangfedsistLGLVSGLFGAMWSVGAFMGPILGGFL 267
Cdd:cd06174   326 I---------------RGTAFGLLNTFGFLGGAIGPLLAGFL 352
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 4-221 9.74e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 43.72  E-value: 9.74e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   4 LVRIVDAIGFGAAITASSSILAKAFPNN-VATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIF---LGCIVLLMIP 79
Cdd:cd17503    89 IFRILQGFGGGVLIPLAQTILLRIYPPEkRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILALLLAP 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  80 -LNLYILpsyesdpgkqsfwKLVTLPKMGLLAFVIISLSSCFGFLdptLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSP 158
Cdd:cd17503   169 lLDLRLF-------------KDRNFTLGLLLSFLLGLGLFGAMFL---LPLYLQNVLGYSAFESGLVLAPGGLASAILSP 232

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720362617 159 LFGLLSDKMPTlrKWLLVFGNLITAGCYMLLGpvpLLHIKSQLWLLVLVLVVNGISAGMSIIP 221
Cdd:cd17503   233 LVGRLLDKFGP--RLLLLAGLLLLALGTLLLA---FLTPDTSLWLIILPLFIRGLGMGLVFMP 290
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 1-83 1.06e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 43.35  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   1 MCFLVRIVDAIGFGAAITAS-SSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIP 79
Cdd:cd17489   282 MLLLAAVLYGLGFGLLFPALqALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361


                  ....
gi 1720362617  80 LNLY 83
Cdd:cd17489   362 LYIF 365
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 29-142 1.63e-04

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 42.98  E-value: 1.63e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  29 PNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYE------------SDPGKQS 96
Cdd:cd17331   117 PGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTkskrekeakesaSPPSVFN 196

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720362617  97 FWKLVTL---PKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLS---TGYV 142
Cdd:cd17331   197 LKEILRLlrlPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTpeeNGYL 248
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 1-190 3.57e-04

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 41.72  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   1 MCFLVRIVDAIGFGAAITASSSILAKAFPNNV-ATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIP 79
Cdd:COG0477   104 LLIAARALQGIGAGGLMPGALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALV 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  80 LNLYILPSYESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPL 159
Cdd:COG0477   184 LRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALL 263

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1720362617 160 FGLLSDKMPTLRKWLLVFGNLITAGCYMLLG 190
Cdd:COG0477   264 LLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
102-289 3.69e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.78  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 102 TLPKMGLLAFVIISLSSCFGFLD----PTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVF 177
Cdd:COG2271     3 APSRYRWRILALLFLAYFLNYLDrsnlSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG--RRRVLAI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 178 GNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMsiiptfpEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGA 257
Cdd:COG2271    81 GLLLWGLATLLFGFAT------SFWQLLLLRFLLGLGEAG-------FFPAALKLIAEWFPPKERGRALGIFNAGGPLGG 147

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1720362617 258 FMGPILGGFLCEKIGFEWAAAMQGLWTLLSGV 289
Cdd:COG2271   148 ALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL 179
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
11-296 4.41e-04

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 41.78  E-value: 4.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  11 IGFGAAITASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYIL----P 86
Cdd:COG2807   118 AGIAVGNVLLPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLrrrpA 197

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  87 SYESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKfSLSTGYVGLVFLGLSLSYAISSPLFGLLSDK 166
Cdd:COG2807   198 AAAAAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADR 276

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 167 MPTLRKWLLVFGNLITAGCY-MLLGPVPLLHiksqLWLLVLvlvvnGISAGMSIIptfpemLSCAYANGFEDSISTLGLV 245
Cdd:COG2807   277 LGDRRPLLLLLGLLGLAGLLgLLLAPGSLPW----LWAVLL-----GLGQGGLFP------LALTLIGLRARTPAEAAAL 341

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720362617 246 SGLFGAMWSVGAFMGPILGGFLcekigFEWAAAMQGLWTLLSGVSMALFYL 296
Cdd:COG2807   342 SGMAQSVGYLLAALGPLLVGAL-----HDATGSWTAALLLLAALAVLMLVA 387
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
104-297 7.74e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.99  E-value: 7.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 104 PKMGLLAFVIISLS-SCFGFLD---PTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGN 179
Cdd:COG0738     3 KKNYRRALIAIYLLfFLWGFATalwGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFG--YKRGLLLGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 180 LITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGfedsistlGLVSGLFGAMWSVGAFM 259
Cdd:COG0738    81 LLMALGLLLFALAP------SYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA--------ASRLNLLHAFFSLGALL 146

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1720362617 260 GPILGGFLcekIGFEWAAAMQGLWTLLSGVSMALFYLW 297
Cdd:COG0738   147 GPLLGGLL---ILLGLSLSWHLPYLILAVLLLLLALLF 181
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 119-293 9.19e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 40.67  E-value: 9.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 119 CFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGpvpllhIK 198
Cdd:cd17329    14 GFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFG--RKPVMLAGLLLRALGFALLG------FA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 199 SQLWLLVLVLVVNGISAGMsIIPTFPEMLSCAYANGfedsisTLGLVSGLFGAMWSVGAFMGPILGGFLCEkIGFEWAAA 278
Cdd:cd17329    86 HSPWLFAIALVLTGFGGGL-FEPASEAMIADVTTPE------NRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFL 157

                         170
                  ....*....|....*
gi 1720362617 279 MQGLWTLLSGVSMAL 293
Cdd:cd17329   158 AAAVLFLLAALVLLF 172
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 1-155 1.53e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 39.93  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617   1 MCFLVRIVDAIGFGAAITASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQsFGYEVPFIFLGCIVLLMIPL 80
Cdd:cd17388    93 WLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFLVAAGLNGLNFLL 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  81 NLYILPsyESDPGKQ-------------SFWKLVTLPKMG--LLAFVIISLSSCFGFldPTLSLFVMEKFSLSTGYVGLV 145
Cdd:cd17388   172 GLFVLP--ESLPPERrrafrwrranpfgSLRWLTGFPGLLglLAVFFLIQLIGQVPA--TTWVLFTEDRFDWSPTMVGLS 247

                         170
                  ....*....|
gi 1720362617 146 FLGLSLSYAI 155
Cdd:cd17388   248 LAVFGLLHAL 257
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
120-297 2.25e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.50  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 120 FGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTL---RKWLLVFGNLITAGCYMLLGPVPLLH 196
Cdd:COG2211    26 FGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrRRPWILIGAIPLALSFVLLFTAPDLS 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 197 IKSQLWLLVLVLVVNGISAGMSIIPTfpEMLSCAYANGFEDSIStlglVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWA 276
Cdd:COG2211   106 PTGKLIYALVTYLLLGLAYTLVNIPY--SALGAELTPDYEERTR----LSSWRFAFAGLGGLLASVLPPPLVAAFGGDAA 179

                         170       180
                  ....*....|....*....|.
gi 1720362617 277 AAMQgLWTLLSGVSMALFYLW 297
Cdd:COG2211   180 LGYR-LTALIFAVLGLLAFLL 199
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 126-307 3.41e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 38.75  E-value: 3.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 126 TLSLFVMEKFSlSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCyMLLGPVPLLHIKSQLWLLV 205
Cdd:cd06173    21 ALPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLADRFD--RRRLLILADLLRALL-AAVLALLALLGSLSLWLLL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 206 LVLVVNGISAGMSIIP---TFPEMLScayangfEDSISTLglvSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGL 282
Cdd:cd06173    97 VLAFLLGIASAFFGPArqaLLPELVP-------KEQLVRA---NALNSLATQLARIIGPALGGLLVALLGPGGAFAINAL 166

                         170       180
                  ....*....|....*....|....*
gi 1720362617 283 WTLLSGVSMALFYLWEDSTARRRSK 307
Cdd:cd06173   167 SFLLSALLLLFIRRPPPAAPGESSS 191
PRK03545 PRK03545
putative arabinose transporter; Provisional
 16-192 4.67e-03

putative arabinose transporter; Provisional


Pssm-ID: 179591 [Multi-domain]  Cd Length: 390  Bit Score: 38.33  E-value: 4.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  16 AITASSSILAkAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYESDpGKQ 95
Cdd:PRK03545  116 SITASLAIRV-APAGKKAQALSLLATGTALAMVLGLPLGRVIGQYLGWRTTFLAIGGGALITLLLLIKLLPLLPSE-HSG 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  96 SFWKLVTLPK----MGLLAFVIISLS---SCFGFLDPtlslFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMP 168
Cdd:PRK03545  194 SLKSLPLLFRrpalVSLYLLTVVVVTahfTAYSYIEP----FVQQVAGLSENFATLLLLLFGGAGIIGSVLFSRLGNRHP 269

                         170       180
                  ....*....|....*....|....
gi 1720362617 169 TLrkwLLVFGNLITAGCYMLLGPV 192
Cdd:PRK03545  270 SG---FLLIAIALLLVCLLLLLPA 290
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 11-289 5.44e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 38.31  E-value: 5.44e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  11 IGFGAAI--TASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLG----CIVLLMIPLNLYI 84
Cdd:cd17478    94 AGIGSAAfhPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIipglAVALLLLRLRPLK 173

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617  85 LPSYESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPT--LSLFVMEKFS--LSTGYVGLVFLGLSlsyAISSPLF 160
Cdd:cd17478   174 KPEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTtfLPFYLVQRGYslVFAGLLLSLFLFAG---AIGTLIG 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720362617 161 GLLSDKMPtlRKWLLVFGNLITAGCYMLLgpvpllhIKSQLWLLVLVLVVNGISAGMSiiptFPEMLSCAYangfEDSIS 240
Cdd:cd17478   251 GPLSDRFG--RRRVIIASLLLAAPFLLLF-------LLTPGIWSYILLVLAGFLLFAS----FPVTVVLAQ----ELLPG 313

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720362617 241 TLGLVSGL-FGAMWSVGAFMGPILgGFLCEKIGFEWAAAMQGLWTLLSGV 289
Cdd:cd17478   314 NVGLASGLmMGLSFGLGGIGAPVL-GALADAFGLESVLLILALLPLLGAL 362
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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