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Conserved domains on  [gi|1720375069|ref|XP_030103088|]
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phosphatase and actin regulator 1 isoform X6 [Mus musculus]

Protein Classification

RPEL domain-containing protein( domain architecture ID 13681330)

RPEL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
369-393 5.17e-06

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.85  E-value: 5.17e-06
                           10        20
                   ....*....|....*....|....*
gi 1720375069  369 KLTRRLSQRPTAEELEQRNILKPRN 393
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
406-431 2.45e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 40.92  E-value: 2.45e-05
                           10        20
                   ....*....|....*....|....*.
gi 1720375069  406 RRLTRKLSQRPTVEELRERKILIRFS 431
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 48-69 5.08e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


:

Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.95  E-value: 5.08e-05
                          10        20
                  ....*....|....*....|..
gi 1720375069  48 LERKISMRQSREELIKRGVLKE 69
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL super family cl29414
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 330-354 1.08e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


The actual alignment was detected with superfamily member smart00707:

Pssm-ID: 475195  Cd Length: 26  Bit Score: 36.30  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|....*
gi 1720375069  330 DSLAIKLSNRPSKRELEEKNILPRQ 354
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKEL 25
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 81-291 6.84e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375069  81 NEDDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDimdGPDPGAPVKLPC-------LPVKLSPPLPPKKV 153
Cdd:pfam03154 154 NESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATA---GPTPSAPSVPPQgspatsqPPNQTQSTAAPHTL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375069 154 LICMPVGGPE-----------LTLASYAAQKSSQQAVAQHHHTVLPSqMQHQLQYG-SHGQHlPSSTGTLPMHPSGCRMI 221
Cdd:pfam03154 231 IQQTPTLHPQrlpsphpplqpMTQPPPPSQVSPQPLPQPSLHGQMPP-MPHSLQTGpSHMQH-PVPPQPFPLTPQSSQSQ 308

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375069 222 DELNKTLAMTMQrlESSEQRVPCSTSYHSSGLHSSDGITKAGPMGLPEIRQVPTVVIECDDNKENVPHEP 291
Cdd:pfam03154 309 VPPGPSPAAPGQ--SQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP 376
 
Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
369-393 5.17e-06

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.85  E-value: 5.17e-06
                           10        20
                   ....*....|....*....|....*
gi 1720375069  369 KLTRRLSQRPTAEELEQRNILKPRN 393
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 369-391 1.03e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 41.88  E-value: 1.03e-05
                          10        20
                  ....*....|....*....|...
gi 1720375069 369 KLTRRLSQRPTAEELEQRNILKP 391
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPE 23
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
406-431 2.45e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 40.92  E-value: 2.45e-05
                           10        20
                   ....*....|....*....|....*.
gi 1720375069  406 RRLTRKLSQRPTVEELRERKILIRFS 431
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 48-69 5.08e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.95  E-value: 5.08e-05
                          10        20
                  ....*....|....*....|..
gi 1720375069  48 LERKISMRQSREELIKRGVLKE 69
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 407-427 7.31e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 36.87  E-value: 7.31e-04
                          10        20
                  ....*....|....*....|.
gi 1720375069 407 RLTRKLSQRPTVEELRERKIL 427
Cdd:pfam02755   1 SLERKLSHRPTREELVERNIL 21
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
330-354 1.08e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.30  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|....*
gi 1720375069  330 DSLAIKLSNRPSKRELEEKNILPRQ 354
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKEL 25
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 331-352 1.09e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 36.10  E-value: 1.09e-03
                          10        20
                  ....*....|....*....|..
gi 1720375069 331 SLAIKLSNRPSKRELEEKNILP 352
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILP 22
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
48-69 3.62e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 34.76  E-value: 3.62e-03
                           10        20
                   ....*....|....*....|..
gi 1720375069   48 LERKISMRQSREELIKRGVLKE 69
Cdd:smart00707   3 LNRKLSQRPTREELEERNILKE 24
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 81-291 6.84e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375069  81 NEDDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDimdGPDPGAPVKLPC-------LPVKLSPPLPPKKV 153
Cdd:pfam03154 154 NESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATA---GPTPSAPSVPPQgspatsqPPNQTQSTAAPHTL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375069 154 LICMPVGGPE-----------LTLASYAAQKSSQQAVAQHHHTVLPSqMQHQLQYG-SHGQHlPSSTGTLPMHPSGCRMI 221
Cdd:pfam03154 231 IQQTPTLHPQrlpsphpplqpMTQPPPPSQVSPQPLPQPSLHGQMPP-MPHSLQTGpSHMQH-PVPPQPFPLTPQSSQSQ 308

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375069 222 DELNKTLAMTMQrlESSEQRVPCSTSYHSSGLHSSDGITKAGPMGLPEIRQVPTVVIECDDNKENVPHEP 291
Cdd:pfam03154 309 VPPGPSPAAPGQ--SQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP 376
 
Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
369-393 5.17e-06

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 42.85  E-value: 5.17e-06
                           10        20
                   ....*....|....*....|....*
gi 1720375069  369 KLTRRLSQRPTAEELEQRNILKPRN 393
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 369-391 1.03e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 41.88  E-value: 1.03e-05
                          10        20
                  ....*....|....*....|...
gi 1720375069 369 KLTRRLSQRPTAEELEQRNILKP 391
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPE 23
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
406-431 2.45e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 40.92  E-value: 2.45e-05
                           10        20
                   ....*....|....*....|....*.
gi 1720375069  406 RRLTRKLSQRPTVEELRERKILIRFS 431
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 48-69 5.08e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 39.95  E-value: 5.08e-05
                          10        20
                  ....*....|....*....|..
gi 1720375069  48 LERKISMRQSREELIKRGVLKE 69
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 407-427 7.31e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 36.87  E-value: 7.31e-04
                          10        20
                  ....*....|....*....|.
gi 1720375069 407 RLTRKLSQRPTVEELRERKIL 427
Cdd:pfam02755   1 SLERKLSHRPTREELVERNIL 21
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
330-354 1.08e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.30  E-value: 1.08e-03
                           10        20
                   ....*....|....*....|....*
gi 1720375069  330 DSLAIKLSNRPSKRELEEKNILPRQ 354
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKEL 25
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 331-352 1.09e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 36.10  E-value: 1.09e-03
                          10        20
                  ....*....|....*....|..
gi 1720375069 331 SLAIKLSNRPSKRELEEKNILP 352
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILP 22
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
48-69 3.62e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 34.76  E-value: 3.62e-03
                           10        20
                   ....*....|....*....|..
gi 1720375069   48 LERKISMRQSREELIKRGVLKE 69
Cdd:smart00707   3 LNRKLSQRPTREELEERNILKE 24
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 81-291 6.84e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 6.84e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375069  81 NEDDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDimdGPDPGAPVKLPC-------LPVKLSPPLPPKKV 153
Cdd:pfam03154 154 NESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATA---GPTPSAPSVPPQgspatsqPPNQTQSTAAPHTL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375069 154 LICMPVGGPE-----------LTLASYAAQKSSQQAVAQHHHTVLPSqMQHQLQYG-SHGQHlPSSTGTLPMHPSGCRMI 221
Cdd:pfam03154 231 IQQTPTLHPQrlpsphpplqpMTQPPPPSQVSPQPLPQPSLHGQMPP-MPHSLQTGpSHMQH-PVPPQPFPLTPQSSQSQ 308

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375069 222 DELNKTLAMTMQrlESSEQRVPCSTSYHSSGLHSSDGITKAGPMGLPEIRQVPTVVIECDDNKENVPHEP 291
Cdd:pfam03154 309 VPPGPSPAAPGQ--SQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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