|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
103-454 |
1.41e-139 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 415.00 E-value: 1.41e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 179
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 180 VKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpeDKRRYFikmGNYLKIAMM-------TLDLAASnlnllrpAkppG 252
Cdd:cd03586 81 IMEILREYTPLVEPLSIDEAYLDVT-----------DYVRLF---GSATEIAKEirarireETGLTAS-------A---G 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 253 IAPNTMLAKVCSDKNKPNGQYQILPSrsAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSW 332
Cdd:cd03586 137 IAPNKFLAKIASDLNKPNGLTVIPPE--DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 333 HYFLHIALGLGSTDLARDGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRA 411
Cdd:cd03586 215 RRLYELARGIDNRPVEPDRERKSIGVERTFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRS 294
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1720375319 412 STVPAAISTAEEIFAIAKELLRTEvnvgsPHPLRLRLMGVRMS 454
Cdd:cd03586 295 RTLPEPTDDAEDIYELALELLEEL-----LDGRPIRLLGVRLS 332
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
107-462 |
5.44e-99 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 310.51 E-value: 5.44e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 107 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 182
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 183 ILAEYDPNFMAMSLDEAYLNITQHLQErqdwpedkrryfikMGNYLKIAMM-------TLDLAASnlnllrpAkppGIAP 255
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVTDNKLC--------------IGSATLIAQEirqdifeELGLTAS-------A---GVAP 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 256 NTMLAKVCSDKNKPNGQYQILPSRsaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELyQQRALLSLLfsetswHYF 335
Cdd:PRK02406 137 NKFLAKIASDWNKPNGLFVITPEE--VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELI------RHF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 336 ------LHialglgstDLAR---------DGERKSMSVERTFSEISKTEEQyslCQE----LCAELAHDLQKEG--LKGR 394
Cdd:PRK02406 208 gkfgrrLY--------ERARgiderpvkpDRERKSVGVERTFAEDLYDLEA---CLAelprLAEKLERRLERAKpdKRIK 276
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720375319 395 TVTIKLKNVNFEVKTRaSTVPAAISTAEEIFAIAKELLRTEVNVGsphplrLRLMGVRMSTFSSEDDR 462
Cdd:PRK02406 277 TVGVKLKFADFQQTTK-EHTADPLDKADLIELLAQALLRRLGGRG------VRLLGVGVTLLEPQLER 337
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
101-454 |
1.89e-97 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 306.30 E-value: 1.89e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 177
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 178 KEVKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpeDKRRYFikmGNYLKIAMMTLDLAASNLNLlrpakpP---GIA 254
Cdd:COG0389 82 RRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF---GSAEAIARRIRRRIRRETGL------TvsvGIA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 255 PNTMLAKVCSDKNKPNGQYQILPSRsaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ-RALLSLLFSETsWH 333
Cdd:COG0389 142 PNKFLAKIASDLAKPDGLTVIPPGE--VAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGKV-GE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 334 YFLHIALGLGSTDLARDGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRAS 412
Cdd:COG0389 219 RLYRLARGIDPRPVEPRRPRKSIGVERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSR 298
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1720375319 413 TVPAAISTAEEIFAIAKELLRTEVNVGSPhplrLRLMGVRMS 454
Cdd:COG0389 299 TLPEPTDDTAELLRAARELLERIYRPGRP----VRLLGVRLS 336
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
105-265 |
3.55e-44 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 156.20 E-value: 3.55e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 105 VDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 181
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 182 EILAEY-DPNFMAMSLDEAYLNITqHLQERQDWPEDkrryfikMGNYLKIAMMT-LDLAASnlnllrpakpPGIAPNTML 259
Cdd:pfam00817 81 EILRRFsTPKVEQASIDEAFLDLT-GLEKLFGAEEA-------LAKRLRREIAEeTGLTCS----------IGIAPNKLL 142
|
....*.
gi 1720375319 260 AKVCSD 265
Cdd:pfam00817 143 AKLASD 148
|
|
| ZnF_Rad18 |
smart00734 |
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ... |
561-586 |
2.04e-05 |
|
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.
Pssm-ID: 128973 [Multi-domain] Cd Length: 24 Bit Score: 41.82 E-value: 2.04e-05
|
| ZnF_Rad18 |
smart00734 |
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ... |
702-728 |
6.23e-05 |
|
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.
Pssm-ID: 128973 [Multi-domain] Cd Length: 24 Bit Score: 40.28 E-value: 6.23e-05
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
103-454 |
1.41e-139 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 415.00 E-value: 1.41e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 179
Cdd:cd03586 1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 180 VKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpeDKRRYFikmGNYLKIAMM-------TLDLAASnlnllrpAkppG 252
Cdd:cd03586 81 IMEILREYTPLVEPLSIDEAYLDVT-----------DYVRLF---GSATEIAKEirarireETGLTAS-------A---G 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 253 IAPNTMLAKVCSDKNKPNGQYQILPSrsAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSW 332
Cdd:cd03586 137 IAPNKFLAKIASDLNKPNGLTVIPPE--DVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSG 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 333 HYFLHIALGLGSTDLARDGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRA 411
Cdd:cd03586 215 RRLYELARGIDNRPVEPDRERKSIGVERTFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRS 294
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1720375319 412 STVPAAISTAEEIFAIAKELLRTEvnvgsPHPLRLRLMGVRMS 454
Cdd:cd03586 295 RTLPEPTDDAEDIYELALELLEEL-----LDGRPIRLLGVRLS 332
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
107-462 |
5.44e-99 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 310.51 E-value: 5.44e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 107 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 182
Cdd:PRK02406 1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 183 ILAEYDPNFMAMSLDEAYLNITQHLQErqdwpedkrryfikMGNYLKIAMM-------TLDLAASnlnllrpAkppGIAP 255
Cdd:PRK02406 81 IFRRYTDLIEPLSLDEAYLDVTDNKLC--------------IGSATLIAQEirqdifeELGLTAS-------A---GVAP 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 256 NTMLAKVCSDKNKPNGQYQILPSRsaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELyQQRALLSLLfsetswHYF 335
Cdd:PRK02406 137 NKFLAKIASDWNKPNGLFVITPEE--VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELI------RHF 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 336 ------LHialglgstDLAR---------DGERKSMSVERTFSEISKTEEQyslCQE----LCAELAHDLQKEG--LKGR 394
Cdd:PRK02406 208 gkfgrrLY--------ERARgiderpvkpDRERKSVGVERTFAEDLYDLEA---CLAelprLAEKLERRLERAKpdKRIK 276
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720375319 395 TVTIKLKNVNFEVKTRaSTVPAAISTAEEIFAIAKELLRTEVNVGsphplrLRLMGVRMSTFSSEDDR 462
Cdd:PRK02406 277 TVGVKLKFADFQQTTK-EHTADPLDKADLIELLAQALLRRLGGRG------VRLLGVGVTLLEPQLER 337
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
101-454 |
1.89e-97 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 306.30 E-value: 1.89e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 177
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 178 KEVKEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpeDKRRYFikmGNYLKIAMMTLDLAASNLNLlrpakpP---GIA 254
Cdd:COG0389 82 RRVMAILERYTPLVEPLSIDEAFLDVT-----------GSARLF---GSAEAIARRIRRRIRRETGL------TvsvGIA 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 255 PNTMLAKVCSDKNKPNGQYQILPSRsaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ-RALLSLLFSETsWH 333
Cdd:COG0389 142 PNKFLAKIASDLAKPDGLTVIPPGE--VAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGKV-GE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 334 YFLHIALGLGSTDLARDGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRAS 412
Cdd:COG0389 219 RLYRLARGIDPRPVEPRRPRKSIGVERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSR 298
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1720375319 413 TVPAAISTAEEIFAIAKELLRTEVNVGSPhplrLRLMGVRMS 454
Cdd:COG0389 299 TLPEPTDDTAELLRAARELLERIYRPGRP----VRLLGVRLS 336
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
16-478 |
1.89e-80 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 269.20 E-value: 1.89e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 16 LRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQIT--------SQQLRKAQLQVDK 87
Cdd:PTZ00205 42 FQLTLDCNKAGMGNVDKERVEAIIRNVSEGSSFLMNEQRLAEGREKQLQELKRKSSLFTqllggernAAQRKQWELKVSK 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 88 FAMELERNRNLNnTIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVP 167
Cdd:PTZ00205 122 IEQELEATRRLG-TYIHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILP 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 168 PNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQ--ERQDWPEDkrryfikMGNYLKIAMM-TLDLAASnlnl 244
Cdd:PTZ00205 201 PDFDAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYIErfEGTKTAED-------VASELRVRVFgETKLTAS---- 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 245 lrpakpPGIAPNTMLAKVCSDKNKPNGQYQI-LPSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALL 323
Cdd:PTZ00205 270 ------AGIGPTAALAKIASNINKPNGQHDLnLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVEL 343
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 324 SLLFSETSWHYFLHIALGL------------GSTDLARDGERKSMSVERTFSEISKTEEQYSLCQELCAELAHDLQKEGL 391
Cdd:PTZ00205 344 CYILHNNLFRFLLGASIGImqwpdaataantENCEGATGGQRKAISSERSFTTPRTKEGLQEMVDTVFNGAYEEMRKSEL 423
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 392 KGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLRtevnvgsPHPLR---LRLMGVRMSTFSSEDDRkHQQRs 468
Cdd:PTZ00205 424 MCRQISLTIRWASYRYQQYTKSLIQYSDDSATLRRAVDGLLL-------PHAAKyseMCLLGVRFLDLISAKDF-HMKR- 494
|
490
....*....|
gi 1720375319 469 iigflQAGNQ 478
Cdd:PTZ00205 495 -----KGGNQ 499
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
98-469 |
2.00e-69 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 232.30 E-value: 2.00e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 98 LNNTIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 174
Cdd:PRK14133 1 MDRVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISergVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 175 AVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQErqdwPEDKRRYfIKmgnylKIAMMTLDLAASnlnllrpakpPGIA 254
Cdd:PRK14133 81 EVSKNIFKILYEVTPIVEPVSIDEAYLDITNIKEE----PIKIAKY-IK-----KKVKKETGLTLS----------VGIS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 255 PNTMLAKVCSDKNKPNGQYQIlpSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ-QRALLSLLFSETSWH 333
Cdd:PRK14133 141 YNKFLAKLASDWNKPDGIKII--TEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKlSREFLIEYFGKFGVE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 334 YFLHIAlGLGSTDLARDGERKSMSVERTFS-EISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRAS 412
Cdd:PRK14133 219 IYERIR-GIDYREVEVSRERKSIGKETTLKkDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSK 297
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1720375319 413 TVPAAISTAEEIFAIAKELLRtEVNVGSPhplrLRLMGVRMSTFSSEddrKHQQRSI 469
Cdd:PRK14133 298 TLNDYIRDKEEIYNVACEILE-HINIKEP----IRLIGLSVSNLSEN---KIEQLSF 346
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
101-461 |
3.15e-66 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 225.97 E-value: 3.15e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVG--SMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 178
Cdd:PRK02794 37 SIAHIDCDAFYASVEKRDNPELRDKPVIIGggKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVGR 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 179 EVKEILAEYDPNFMAMSLDEAYLNI--TQHLQErqdwpedkrryfikmgnylkiammtldlAASNLNLLRPAK------- 249
Cdd:PRK02794 117 EVRAMMQALTPLVEPLSIDEAFLDLsgTERLHG----------------------------APPAVVLARFARrvereig 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 250 ---PPGIAPNTMLAKVCSDKNKPNGqYQILpSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ--QRALLS 324
Cdd:PRK02794 169 itvSVGLSYNKFLAKIASDLDKPRG-FSVI-GRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRadEADLMR 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 325 LLFSETSWHYflHIALGLGSTDLARDGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNV 403
Cdd:PRK02794 247 RFGSMGLRLW--RLARGIDDRKVSPDREAKSVSAETTFETdLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTA 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1720375319 404 NFEVKTRASTVPAAISTAEEIFAIAKELLRTEvnvgsPHPLRLRLMGVRMSTFSSEDD 461
Cdd:PRK02794 325 DFRLRTRRRTLEDPTQLADRIFRTARELLEKE-----TDGTAFRLIGIGVSDLSPADE 377
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
101-458 |
1.39e-60 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 211.72 E-value: 1.39e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQL-IIVPPNFDKYRAV 176
Cdd:PRK03348 6 WVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGgrgVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFVVYRAA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 177 SKEVKEILAEYDPNFMAMSLDEAYLNITQHL----QERQDWPEDKRRyfikmgnylKIAMMTlDLAASnlnllrpakpPG 252
Cdd:PRK03348 86 SRRVFDTLRELSPVVEQLSFDEAFVEPAELAgasaEEVEAFAERLRA---------RVREET-GLPAS----------VG 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 253 IAPNTMLAKVCSDKNKPNGQYQILPSRSavMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ--QRALLSLLfSET 330
Cdd:PRK03348 146 AGSGKQIAKIASGLAKPDGIRVVPPGEE--RELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAAlsEAEVANLL-GAT 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 331 SWHYFLHIALGLGSTDLARDGERKSMSVERTFSEISKTEEQYSLCQELCAELAHD-LQKEGLKGRTVTIKLKNVNFEVKT 409
Cdd:PRK03348 223 VGPALHRLARGIDDRPVAERAEAKQISAESTFAVDLTTRAQLREAIERIAEHAHRrLLKDGRGARTVTVKLRKSDFSTLT 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1720375319 410 RASTVPAAISTAEEIFAIAKELLRTEVNVGSphplrLRLMGVRMSTFSS 458
Cdd:PRK03348 303 RSATLPYATDDAAVLAATARRLLLDPDEIGP-----IRLVGVGFSGLSD 346
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
103-454 |
4.07e-56 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 196.04 E-value: 4.07e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 103 VHVDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 178
Cdd:cd00424 1 LHIDFDNFFASVEQLARPELKGRPVVVvpfnSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 179 EVKEILAEYDPNFMAMSLDEAYLNIT---QHLQERQDWPEDKRRyfikmgnylKIAMMTLDLAASnlnllrpakpPGIAP 255
Cdd:cd00424 81 RLLSELEEVAPLVEVASIDELFLDLTgsaRLLGLGSEVALRIKR---------HIAEQLGGITAS----------IGIAS 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 256 NTMLAKVCSDKNKPNGQYQILPsrSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELY--QQRALLSLLFSETS-- 331
Cdd:cd00424 142 NKLLAKLAAKYAKPDGLTILDP--EDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLaaSPDALLALWGGVSGer 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 332 WHYFLHialGLGSTDLARDGERKSMSVERTFSEISKTEEQ-YSLCQELCAELAHDLQKEGLKGRTVTIKLKNVN------ 404
Cdd:cd00424 220 LWYALR---GIDDEPLSPPRPRKSFSHERVLPRDSRNAEDaRPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDgrwsgh 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1720375319 405 FEVKTRASTVPAAISTaEEIFAIAKELLRTEVNVgsPHPLRLRLMGVRMS 454
Cdd:cd00424 297 ADIPSRSAPRPISTED-GELLHALDKLWRALLDD--KGPRRLRRLGVRLS 343
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
102-508 |
6.11e-55 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 194.86 E-value: 6.11e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 102 IVHVDMDAFYAAVEMRDNPELKDKPIAV-GSMS----MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAV 176
Cdd:PRK01810 7 IFHVDMNSFFASVEIAYDPSLQGKPLAVaGNEKerkgIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYREA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 177 SKEVKEILAEYDPNFMAMSLDEAYLNITQhlqerqdwpedkrryFIKMGNYLKIAMM-------TLDLAASnlnllrpak 249
Cdd:PRK01810 87 SRQMFQILSEFTPLVQPVSIDEGYLDITD---------------CYALGSPLEIAKMiqqrlltELQLPCS--------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 250 pPGIAPNTMLAKVCSDKNKPNGqYQILPSRSaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ-QRALLSLLFS 328
Cdd:PRK01810 143 -IGIAPNKFLAKMASDMKKPLG-ITVLRKRD-VPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKaDEHILRAKLG 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 329 ETSWHyfLH-IALGL--GSTDLARDGERKSMSVERTFSEISKTE-EQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVN 404
Cdd:PRK01810 220 INGVR--LQrRANGIddRPVDPEAIYQFKSVGNSTTLSHDMDEEkELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHD 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 405 FEVKTRASTVPAAISTAEEIFAIAKELLRTEVNvGSPhplrLRLMGV-------------RMSTFSSEDDRKHQQ-RSII 470
Cdd:PRK01810 298 RRTITRSKTLKNPIWEKRDIFQAASRLFKQHWN-GDP----VRLLGVtatdlewkteavkQLDLFSFEEDAKEEPlLAVI 372
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 1720375319 471 GFLQA--GNQALSSTGDSLDKTDKTElakplEMSHKKSFF 508
Cdd:PRK01810 373 DQINDkyGMPLLQRGSQLLRKQEKTF-----GTSFEKDFM 407
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
101-487 |
3.52e-53 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 189.81 E-value: 3.52e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEV 180
Cdd:PRK03858 5 SILHADLDSFYASVEQRDDPALRGRPVIVGGGVVLAAS-YEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRASKAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 181 KEILAEYDPNFMAMSLDEAYLNITqhlqerqdwpeDKRRYFikmGNYLKIAmmtldlAASNLNLLRPAKPP---GIAPNT 257
Cdd:PRK03858 84 FEVFRDTTPLVEGLSIDEAFLDVG-----------GLRRIS---GTPVQIA------ARLRRRVREEVGLPitvGVARTK 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 258 MLAKVCSDKNKPNGQYQILPSRSavMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ--QRALLSLLFSETSWHyf 335
Cdd:PRK03858 144 FLAKVASQVAKPDGLLVVPPDRE--LAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAElpESALVSLLGPAAGRH-- 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 336 LHiALGlgstdLARD-------GERKSMSVERTFSEISKTEEQY--SLCQeLCAELAHDLQKEGLKGRTVTIKLKNVNFE 406
Cdd:PRK03858 220 LH-ALA-----HNRDprrvetgRRRRSVGAQRALGRGPNSPAEVdaVVVA-LVDRVARRMRAAGRTGRTVVLRLRFDDFT 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 407 VKTRASTVPAAISTAEEIFAIAKELLRtevNVGSPHPLR-LRLMGVRMSTFsseDDRKHQQRSIIGFLQAGNQALSSTGD 485
Cdd:PRK03858 293 RATRSHTLPRPTASTATLLAAARDLVA---AAAPLIAERgLTLVGFAVSNL---DDDGAQQLELPFGLRRPGSALDAALD 366
|
..
gi 1720375319 486 SL 487
Cdd:PRK03858 367 AV 368
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
98-434 |
1.03e-47 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 174.42 E-value: 1.03e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 98 LNNTIVHVDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLATSNYHARRFGVRAAMpgFI--AKRLCPQLIIVPPNFD 171
Cdd:cd01701 45 LQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVchgkGPNSEIASCNYEARSYGIKNGM--WVgqAKKLCPQLVTLPYDFE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 172 KYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQDWPEDK----RRyfikmgnylKIAMMTlDLAASnlnllrp 247
Cdd:cd01701 123 AYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETYELPEELaeaiRN---------EIRETT-GCSAS------- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 248 akpPGIAPNTMLAKVCSDKNKPNGQYQILPsrSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ----RALL 323
Cdd:cd01701 186 ---VGIGPNILLARLATRKAKPDGQYHLSA--EKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRsktkEKLQ 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 324 SLLFSETSWHyFLHIALGLGSTDLARDGERKSMSVERTFSEISKTEEQ-YSLCQELCAELAHDLQKEGLKGRTVTIKLKN 402
Cdd:cd01701 261 KVLGPKTGEK-LYDYCRGIDDRPVTGEKERKSVSAEINYGIRFTNVDDvEQFLQRLSEELSKRLEESNVTGRQITLKLMK 339
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1720375319 403 ------------------VNFevkTRASTVPAAISTAEEIFAIAKELLRT 434
Cdd:cd01701 340 rapgapieppkymghgicDSF---SKSSTLGVATDDSGVIGTEAKKLFRD 386
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
105-265 |
3.55e-44 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 156.20 E-value: 3.55e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 105 VDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 181
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 182 EILAEY-DPNFMAMSLDEAYLNITqHLQERQDWPEDkrryfikMGNYLKIAMMT-LDLAASnlnllrpakpPGIAPNTML 259
Cdd:pfam00817 81 EILRRFsTPKVEQASIDEAFLDLT-GLEKLFGAEEA-------LAKRLRREIAEeTGLTCS----------IGIAPNKLL 142
|
....*.
gi 1720375319 260 AKVCSD 265
Cdd:pfam00817 143 AKLASD 148
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
102-452 |
3.05e-37 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 142.85 E-value: 3.05e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 102 IVHVDMDAFYAAVEMRDNPELKDKPIAVG-------SMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 174
Cdd:PRK03352 7 VLHVDLDQFIAAVELLRRPELAGLPVIVGgngdptePRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAAYD 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 175 AVSKEVKEILAEYDPNFMAMSLDEAYLNItqhlqeRQDWPEDkrryfikmgnyLKIAMMTLDLAASNLNLlrpakPPGIA 254
Cdd:PRK03352 87 AASEEVMATLRDLGVPVEVWGWDEAFLGV------DTDDPEA-----------LAEEIRAAVLERTGLSC-----SVGIG 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 255 PNTMLAKVCSDKNKPNGQYQIlpSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTEL-YQQRALLSLLFSETSWH 333
Cdd:PRK03352 145 DNKLRAKIATGFAKPAGVFRL--TDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLaAADPAELAATFGPTTGP 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 334 YFLHIALGLGSTDL-ARDGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRA 411
Cdd:PRK03352 223 WLLLLARGGGDTEVsAEPWVPRSRSREVTFPQdLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATFYTRTKI 302
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1720375319 412 STVPAAISTAEEIFAIAKELLrTEVNVGSPhplrLRLMGVR 452
Cdd:PRK03352 303 RKLPEPTTDPDVIEAAALDVL-DRFELDRP----VRLLGVR 338
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
102-469 |
3.82e-37 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 144.38 E-value: 3.82e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 102 IVHVDMDAFYAAVEMRDNPELKDKPIAVG------SMSMLATSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRA 175
Cdd:PRK03103 5 ILLVDMQSFYASVEKAANPELKGRPVIVSgdperrSGVVLAAC-PLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYID 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 176 VSKEVKEILAEYDPNFMAMSLDEAYLNIT-------------QHLQERqdwpedKRRYFikmGNYLKIammtldlaasnl 242
Cdd:PRK03103 84 VSLQITRILEDFTDLVEPFSIDEQFLDVTgsqklfgspleiaQKIQQR------IMRET---GVYARV------------ 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 243 nllrpakppGIAPNTMLAKVCSD---KNKPNGQYQIlpSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELyqq 319
Cdd:PRK03103 143 ---------GIGPNKLLAKMACDnfaKKNPDGLFTL--DKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQL--- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 320 rALLSLLFSETSW----HYFLHIALGLGSTDLARDG--ERKSMSVERTF-SEISKTEEQYSLCQELCAELAHDLQKEGLK 392
Cdd:PRK03103 209 -ANTPLERLKKRWgingEVLWRTANGIDYSPVTPHSldRQKAIGHQMTLpRDYRGFEEIKVVLLELCEEVCRRARAKGYM 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 393 GRTVTIKLKNVNFEVKT---RASTVPAAISTAEEIFAIAKELLRTEVNvGSPhplrLRLMGVRMSTFSSED-------DR 462
Cdd:PRK03103 288 GRTVSVSLRGADFDWPTgfsRQMTLPEPTNLAMEVYEAACKLFHRHWD-GKP----VRRVGVTLSNLVSDDvwqlslfGD 362
|
....*..
gi 1720375319 463 KHQQRSI 469
Cdd:PRK03103 363 RERKRSL 369
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
103-433 |
4.02e-34 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 134.36 E-value: 4.02e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLII--VPP------------ 168
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILahVATykkgedeadyhe 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 169 ---------NFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQER-QDWPEDKRRYfikmgnylkiammtlDLA 238
Cdd:cd01702 81 npsparhkvSLDPYRRASRKILNILKRFGDVVEKASIDEAYLDLGSRIVEEiRQQVYDELGY---------------TCS 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 239 AsnlnllrpakppGIAPNTMLAKVCSDKNKPNGQyQILPSrSAVMDFIKDLPIRKVSGI-GKVTEKMLMALGIVTCTELY 317
Cdd:cd01702 146 A------------GIAHNKMLAKLASGMNKPNAQ-TILRN-DAVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTEGDVA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 318 QQRALLSLL---FSET--SWHYflHIALGLGSTDLARDGERKSMSVERTFS--EISKTEEQYSLCQELCAELAHDLQKE- 389
Cdd:cd01702 212 GFRSSESDLqehFGEKlgEWLY--NLLRGIDHEPVKPRPLPKSMGSSKNFPgkTALSTEDVQHWLLVLASELNSRLEDDr 289
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1720375319 390 ---GLKGRTVTIKLKNVNFEVKTRASTvPAAISTAEEIFAIAKELLR 433
Cdd:cd01702 290 yenNRRPKTLVLSLRQRGDGVRRSRSC-ALPRYDAQKIVKDAFKLIK 335
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
102-310 |
1.09e-33 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 132.99 E-value: 1.09e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 102 IVHVDMDAFYAAVEMRDNPELKDKPIAVGSMS-------MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 174
Cdd:PRK01216 3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVCVYSgrfedsgAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 175 AVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQDwpedkrryFIKMGNYLKiammtldlaASNLNLLRPAKPPGIA 254
Cdd:PRK01216 83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQD--------AYNLGLEIK---------NKILEKEKITVTVGIS 145
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720375319 255 PNTMLAKVCSDKNKPNGQYQILPSRsaVMDFIKDLPIRKVSGIGKVTEKMLMALGI 310
Cdd:PRK01216 146 KNKVFAKIAADMAKPNGIKVIDDEE--VKRFINELDIADIPGIGDITAEKLKKLGV 199
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
103-319 |
5.32e-33 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 131.44 E-value: 5.32e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVP-PNFDKYRAVSKEVK 181
Cdd:cd01703 1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNgEDLTPFRDMSKKVY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 182 EILAEYDPNFMA--MSLDEAYLNITQhlqerqdwpedkRRYFI--KMGNYLKIAM-MTLDLAASnlnllrpakpPGIAPN 256
Cdd:cd01703 81 RLLRSYSWNDRVerLGFDENFMDVTE------------MRLLVasHIAYEMRERIeNELGLTCC----------AGIASN 138
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720375319 257 TMLAKVCSDKNKPNGQYQILP-SRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ 319
Cdd:cd01703 139 KLLAKLVGSVNKPNQQTTLLPpSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEF 202
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
105-433 |
3.94e-25 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 107.63 E-value: 3.94e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 105 VDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLATSNyHARRFGVRAAMPGFIAKRLCPQL--IIVPPNFDKYRAVSKE 179
Cdd:cd01700 3 VDCNSFYASCERVFRPLLLGRPLVVLSnndGCVIARSP-EAKALGIKMGSPYFKVPDLLERHgvAVFSSNYALYGDMSRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 180 VKEILAEYDPNFMAMSLDEAYLNIT--QHLQERQDWPED-KRRYFIKMGNYLKIammtldlaasnlnllrpakppGIAPN 256
Cdd:cd01700 82 IMSILERFSPDVEVYSIDESFLDLTgsLRFGDLEELARKiRRRILQETGIPVTV---------------------GIGPT 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 257 TMLAKVCSD----KNKPNGQYQIL--PSRSAVMdfiKDLPIRKVSGIGKVTEKMLMALGIVT-----CTELYQQRALLSL 325
Cdd:cd01700 141 KTLAKLANDlakkKNPYGGVVDLTdeEVRDKLL---KILPVGDVWGIGRRTAKKLNAMGIHTagdlaQADPDLLRKKFGV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 326 LFSETSWHyfLHialGLGSTDLAR-DGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNV 403
Cdd:cd01700 218 VGERLVRE--LN---GIDCLPLEEyPPPKKSIGSSRSFGRdVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTS 292
|
330 340 350
....*....|....*....|....*....|....
gi 1720375319 404 NF--EVKTRASTVPAAISTAE--EIFAIAKELLR 433
Cdd:cd01700 293 GFsrQPKYYSATNTLPYPTNDtrEIVKAALRLLY 326
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
353-460 |
2.70e-23 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 94.93 E-value: 2.70e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 353 RKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKEL 431
Cdd:pfam11799 1 RKSIGAERTFGRdLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80
|
90 100
....*....|....*....|....*....
gi 1720375319 432 LRTEVnvgspHPLRLRLMGVRMSTFSSED 460
Cdd:pfam11799 81 LRRLY-----RGRPVRLLGVSLSNLVPEG 104
|
|
| ZnF_Rad18 |
smart00734 |
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ... |
561-586 |
2.04e-05 |
|
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.
Pssm-ID: 128973 [Multi-domain] Cd Length: 24 Bit Score: 41.82 E-value: 2.04e-05
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
117-433 |
2.14e-05 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 47.38 E-value: 2.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 117 RDNPELKDKPIAV----GSMSMLATsNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILAEYDPNFM 192
Cdd:cd03468 15 RNRPADDEAPLAVverkKAGRILAC-NAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTPLVA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 193 AMSLDEAYLNITQHLQERQDWPEDKRRyfikmgnyLKIAMMTLDLAASnlnllrpakpPGIAPNTMLAKVCSDKNKPNGQ 272
Cdd:cd03468 94 LDGPDGLLLDVTGCLHLFGGEDALAAS--------LRAALATLGLSAR----------AGIADTPGAAWLLARAGGGRGV 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 273 YQIlPSRSAVMDFIKDLPIRkVSGIGKVTEKMLMALGIVT---CTELYqqRALLSLLFSE--TSWHYFLhialgLGSTDL 347
Cdd:cd03468 156 LRR-EALAAALVLLAPLPVA-ALRLPPETVELLARLGLRTlgdLAALP--RAELARRFGLalLLRLDQA-----YGRDPE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720375319 348 ARDG----ERKSMSVERTF-SEISKTEEQysLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAE 422
Cdd:cd03468 227 PLLFspppPAFDFRLELQLeEPIARGLLF--PLRRLLEQLCAFLALRGLGARRLSLTLFREDGRVTRVLVGLARPSRDDL 304
|
330
....*....|.
gi 1720375319 423 EIFAIAKELLR 433
Cdd:cd03468 305 PLLRLLRERLE 315
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
279-310 |
4.27e-05 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 40.84 E-value: 4.27e-05
10 20 30
....*....|....*....|....*....|..
gi 1720375319 279 RSAVMDFIKDLPIRKVSGIGKVTEKMLMALGI 310
Cdd:pfam11798 1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| ZnF_Rad18 |
smart00734 |
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ... |
702-728 |
6.23e-05 |
|
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.
Pssm-ID: 128973 [Multi-domain] Cd Length: 24 Bit Score: 40.28 E-value: 6.23e-05
|
| |
