NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720378225|ref|XP_030103516|]
View 

interleukin-3 receptor subunit alpha isoform X17 [Mus musculus]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10557932)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain; similar to Homo sapiens interleukin-5 receptor subunit alpha and interferon gamma receptor 2

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 108-218 2.56e-31

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


:

Pssm-ID: 401252  Cd Length: 96  Bit Score: 114.43  E-value: 2.56e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378225 108 DLRCWVHE-GQLSCQWERGPKATGDVHYRMFWRDVRLGPAHnrECPHYHSLDvntagpaphGGHEGCTLDLDTVLGSTPN 186
Cdd:pfam09240   1 DLTCFIHNpSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVL--QCQYYIRDD---------GTRIGCQFDDLEGLSSSFH 69

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720378225 187 spdlvpQVTITVNGSGRAGPVPCMDNTVDLQR 218
Cdd:pfam09240  70 ------QVYICVNGSSSAGPIRSSDQTFQLQN 95
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 108-218 2.56e-31

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 114.43  E-value: 2.56e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378225 108 DLRCWVHE-GQLSCQWERGPKATGDVHYRMFWRDVRLGPAHnrECPHYHSLDvntagpaphGGHEGCTLDLDTVLGSTPN 186
Cdd:pfam09240   1 DLTCFIHNpSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVL--QCQYYIRDD---------GTRIGCQFDDLEGLSSSFH 69

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720378225 187 spdlvpQVTITVNGSGRAGPVPCMDNTVDLQR 218
Cdd:pfam09240  70 ------QVYICVNGSSSAGPIRSSDQTFQLQN 95
 
Name Accession Description Interval E-value
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 108-218 2.56e-31

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 114.43  E-value: 2.56e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720378225 108 DLRCWVHE-GQLSCQWERGPKATGDVHYRMFWRDVRLGPAHnrECPHYHSLDvntagpaphGGHEGCTLDLDTVLGSTPN 186
Cdd:pfam09240   1 DLTCFIHNpSNLSCEWKPGPNAPPDTNYVLYVRKSPLGPVL--QCQYYIRDD---------GTRIGCQFDDLEGLSSSFH 69

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1720378225 187 spdlvpQVTITVNGSGRAGPVPCMDNTVDLQR 218
Cdd:pfam09240  70 ------QVYICVNGSSSAGPIRSSDQTFQLQN 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH