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Conserved domains on  [gi|1720383693|ref|XP_030104279|]
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POU domain, class 6, transcription factor 1 isoform X9 [Mus musculus]

Protein Classification

POU family transcription factor( domain architecture ID 11036637)

POU (Pit-Oct-Unc) family transcription factor binds specific DNA sequences to direct gene expression programs, playing a role in orchestrating embryonic development and directing cellular fate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Pou super family cl22952
Pou domain - N-terminal to homeobox domain;
169-243 1.25e-39

Pou domain - N-terminal to homeobox domain;


The actual alignment was detected with superfamily member smart00352:

Pssm-ID: 473999  Cd Length: 75  Bit Score: 134.10  E-value: 1.25e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720383693  169 EDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAE 243
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
265-321 1.77e-21

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 86.01  E-value: 1.77e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383693 265 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN 321
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
41-158 4.79e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK14951:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 4.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693  41 NAQGQVIGALPWVVNSASVATPAPA-----QSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPNTPES-PAKSEV 114
Cdd:PRK14951  368 AAAEAAAPAEKKTPARPEAAAPAAApvaqaAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAaPAAVAL 447
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1720383693 115 QPIQPTQAVPQPAVI--LTSPTPALKPSAATPIPITCSETPTVSQL 158
Cdd:PRK14951  448 APAPPAQAAPETVAIpvRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
169-243 1.25e-39

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 134.10  E-value: 1.25e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720383693  169 EDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAE 243
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
172-243 3.88e-37

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 127.78  E-value: 3.88e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720383693 172 INLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAE 243
Cdd:pfam00157   1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
265-321 1.77e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 86.01  E-value: 1.77e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383693 265 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN 321
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
264-320 3.70e-19

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 79.60  E-value: 3.70e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383693  264 KRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLK 320
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
265-323 1.41e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 75.36  E-value: 1.41e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720383693 265 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTS 323
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
261-320 1.42e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.13  E-value: 1.42e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693 261 PSKKRKRRTsfTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLK 320
Cdd:COG5576    50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
41-158 4.79e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 4.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693  41 NAQGQVIGALPWVVNSASVATPAPA-----QSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPNTPES-PAKSEV 114
Cdd:PRK14951  368 AAAEAAAPAEKKTPARPEAAAPAAApvaqaAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAaPAAVAL 447
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1720383693 115 QPIQPTQAVPQPAVI--LTSPTPALKPSAATPIPITCSETPTVSQL 158
Cdd:PRK14951  448 APAPPAQAAPETVAIpvRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
169-243 1.25e-39

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 134.10  E-value: 1.25e-39
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720383693  169 EDGINLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAE 243
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
172-243 3.88e-37

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 127.78  E-value: 3.88e-37
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720383693 172 INLEEIREFAKNFKIRRLSLGLTQTQVGQALTATEGPAYSQSAICRFEKLDITPKSAQKLKPVLEKWLMEAE 243
Cdd:pfam00157   1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
265-321 1.77e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 86.01  E-value: 1.77e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383693 265 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKN 321
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
264-320 3.70e-19

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 79.60  E-value: 3.70e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720383693  264 KRKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLK 320
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
265-323 1.41e-17

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 75.36  E-value: 1.41e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720383693 265 RKRRTSFTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLKNTS 323
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
261-320 1.42e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.13  E-value: 1.42e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693 261 PSKKRKRRTsfTPQAIEALNAYFEKNPLPTGQEITEIAKELNYDREVVRVWFCNRRQTLK 320
Cdd:COG5576    50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
41-158 4.79e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 4.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693  41 NAQGQVIGALPWVVNSASVATPAPA-----QSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRKPNTPES-PAKSEV 114
Cdd:PRK14951  368 AAAEAAAPAEKKTPARPEAAAPAAApvaqaAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAaPAAVAL 447
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1720383693 115 QPIQPTQAVPQPAVI--LTSPTPALKPSAATPIPITCSETPTVSQL 158
Cdd:PRK14951  448 APAPPAQAAPETVAIpvRVAPEPAVASAAPAPAAAPAAARLTPTEE 493
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
32-172 1.12e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 40.62  E-value: 1.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693  32 PGISSQILTNAQGQVIGALPWVVNSASVATPAPAQSLQVQAVTPQlLLNAQGQVIATLASSPLPQPVAVRKPNTPESPAK 111
Cdd:PRK07994  377 PAASAQATAAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQ-LLAARQQLQRAQGATKAKKSEPAAASRARPVNSA 455
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720383693 112 SEVQPIQPTQAVPQPAVILTSPTPALKPSAATPIPITCSETPT-VSQLVSKPHTPSLDEDGI 172
Cdd:PRK07994  456 LERLASVRPAPSALEKAPAKKEAYRWKATNPVEVKKEPVATPKaLKKALEHEKTPELAAKLA 517
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
53-185 1.26e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.56  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693  53 VVNSASVATPAPAQSLQVQAVTPQLllnAQGQVIATLASSPLPQPVAVRKPNTPESPAKSEV-QPIQPTQAVPQPAVILT 131
Cdd:PRK14950  359 LLVPVPAPQPAKPTAAAPSPVRPTP---APSTRPKAAAAANIPPKEPVRETATPPPVPPRPVaPPVPHTPESAPKLTRAA 435
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1720383693 132 SPTPAlKPSAATPIPitcsetptvsqlvSKPHTPSLDEDGINLEEIREFAKNFK 185
Cdd:PRK14950  436 IPVDE-KPKYTPPAP-------------PKEEEKALIADGDVLEQLEAIWKQIL 475
PHA03247 PHA03247
large tegument protein UL36; Provisional
57-165 3.18e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 3.18e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693   57 ASVATPA--PAQSLQVQAVTPQlllnAQGQVIATLASSPLPQPVAVRKPN-TPESPAKSEVQPIQPTQAVPQ-PAVILTS 132
Cdd:PHA03247  2873 AKPAAPArpPVRRLARPAVSRS----TESFALPPDQPERPPQPQAPPPPQpQPQPPPPPQPQPPPPPPPRPQpPLAPTTD 2948
                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1720383693  133 PTPALKPSAATPIP----ITCSETPTVSQLVSKPHTP 165
Cdd:PHA03247  2949 PAGAGEPSGAVPQPwlgaLVPGRVAVPRFRVPQPAPS 2985
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
3-169 3.42e-03

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 38.95  E-value: 3.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693   3 ISAASLGgqtqiLGSLTTAPVITNTipsmPGISSQILTNAQGQVIGALPW-------VVNSASVATPAPAQSLQVQAVTP 75
Cdd:PRK13335    6 IAKTSLA-----LGLLTTGAITVTT----QSVKAEKIQSTKVDKVPTLKAerlaminITAGANSATTQAANTRQERTPKL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693  76 QLLLNAQGQVIATLASSPLPQPVA--VRKPNTPESPAksevqpiqPTQAVPQPAVILTSPTPalkpSAATPiPITCSETP 153
Cdd:PRK13335   77 EKAPNTNEEKTSASKIEKISQPKQeeQKSLNISATPA--------PKQEQSQTTTESTTPKT----KVTTP-PSTNTPQP 143
                         170
                  ....*....|....*.
gi 1720383693 154 TVSQLVSKPHTPSLDE 169
Cdd:PRK13335  144 MQSTKSDTPQSPTIKQ 159
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
48-162 5.43e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.70  E-value: 5.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693  48 GALPWVVNSASVATPAPAQSLQVQAVTPQlllnAQGQVIATLASSPLPQPVAVRKPNTPESPAKSEVQPIQPTQAVPQPA 127
Cdd:PRK12323  371 GAGPATAAAAPVAQPAPAAAAPAAAAPAP----AAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGG 446
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1720383693 128 VILTSPTPALKPSAATPIPITCSETPTVSQLVSKP 162
Cdd:PRK12323  447 APAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPA 481
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
29-169 6.30e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.32  E-value: 6.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383693  29 PSMPGISSQILTNAQGQVIGALPwVVNSASVATPAPAQSLQVQAVTPQLLLNAQGQVIATLASSPLPQPVAVRK------ 102
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAP-AAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARqasarg 443
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720383693 103 ----PNTPESPAKSEVQPIQPTQAVPQPAVILTSPTPALKPSAATPIPITcSETPTVSQLVSKPHTPSLDE 169
Cdd:PRK12323  444 pggaPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPAD-DDPPPWEELPPEFASPAPAQ 513
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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