NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720383943|ref|XP_030104339|]
View 

lymphocyte antigen 6 complex, locus G2 isoform X1 [Mus musculus]

Protein Classification

Ly-6/uPAR domain-containing protein( domain architecture ID 10061478)

LU (Ly-6 antigen/uPA receptor-like) domain-containing protein similar to GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-106 4.42e-35

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467071  Cd Length: 83  Bit Score: 116.28  E-value: 4.42e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383943  25 QGLECYCCLGVPLETSCKTMTCPYSDGFCVTQEEEVIVDSHTIKVKSNLCLPICPTNPE-TTEFLGNAVNVKTFCCKEDL 103
Cdd:cd23541     1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKNLYfLEEILGTTVNVKTSCCKEDL 80


                  ...
gi 1720383943 104 CNA 106
Cdd:cd23541    81 CNA 83
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-106 4.42e-35

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 116.28  E-value: 4.42e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383943  25 QGLECYCCLGVPLETSCKTMTCPYSDGFCVTQEEEVIVDSHTIKVKSNLCLPICPTNPE-TTEFLGNAVNVKTFCCKEDL 103
Cdd:cd23541     1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKNLYfLEEILGTTVNVKTSCCKEDL 80


                  ...
gi 1720383943 104 CNA 106
Cdd:cd23541    81 CNA 83
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-105 1.59e-13

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 61.40  E-value: 1.59e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720383943  29 CYCCLGVPlETSCKT-MTCPYSDGFCVTQEEEVIVDSHTIKVKSNLCL-PICPtNPETTEFLGNAVNVKTFCCKEDLCN 105
Cdd:pfam00021   1 CYSCLGVS-NEDCLSeVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCArSSCP-RLLSDFINGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-108 3.85e-11

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 55.23  E-value: 3.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383943   27 LECYCCLGVPlETSCKTMT-CPYSDGFCVTQEEEVIVDSHTiKVKSNLC--LPICPTNpETTEFLGNAVNVKTFCCKEDL 103
Cdd:smart00134   1 LQCYSCTGNP-DSSCSSEEeCRSPDDVCLTVVAEVISDSRG-SVVYKGCatSPICPGS-HGYEINLTIAFLKVSCCQTDL 77


                   ....*
gi 1720383943  104 CNAAV 108
Cdd:smart00134  78 CNAAG 82
 
Name Accession Description Interval E-value
TFP_LU_ECD_Ly6A_like cd23541
extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; ...
 25-106 4.42e-35

extracellular domain (ECD) found in mouse Ly-6A like lymphocyte antigens and similar proteins; The family includes mouse Ly-6 lymphocyte antigens, such as Ly-6A/Ly-6E, Ly-6B, Ly-6C1/6C2, Ly-6F, and Ly-6I/Ly-6M. Ly-6A/Ly-6E (also called stem cell antigen 1/SCA-1, or T-cell-activating protein/TAP) and Ly-6C are involved in T-cell activation. Members in this family contain an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467071  Cd Length: 83  Bit Score: 116.28  E-value: 4.42e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383943  25 QGLECYCCLGVPLETSCKTMTCPYSDGFCVTQEEEVIVDSHTIKVKSNLCLPICPTNPE-TTEFLGNAVNVKTFCCKEDL 103
Cdd:cd23541     1 QGLRCYQCLGVPLETSCPSVTCSYPDGVCVSQEVETIVGSQRVKLKNKFCLPFCPKNLYfLEEILGTTVNVKTSCCKEDL 80


                  ...
gi 1720383943 104 CNA 106
Cdd:cd23541    81 CNA 83
UPAR_LY6 pfam00021
u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.
 29-105 1.59e-13

u-PAR/Ly-6 domain; This extracellular disulphide bond rich domain is related to pfam00087.


Pssm-ID: 394978  Cd Length: 77  Bit Score: 61.40  E-value: 1.59e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720383943  29 CYCCLGVPlETSCKT-MTCPYSDGFCVTQEEEVIVDSHTIKVKSNLCL-PICPtNPETTEFLGNAVNVKTFCCKEDLCN 105
Cdd:pfam00021   1 CYSCLGVS-NEDCLSeVTCPLSDGQCVTTTLELPEGNLRGTVVSKGCArSSCP-RLLSDFINGGIISVSESCCQSDLCN 77
LU smart00134
Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type ...
 27-108 3.85e-11

Ly-6 antigen / uPA receptor -like domain; Three-fold repeated domain in urokinase-type plasminogen activator receptor; occurs singly in other GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2). Topology of these domains is similar to that of snake venom neurotoxins.


Pssm-ID: 214530  Cd Length: 85  Bit Score: 55.23  E-value: 3.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383943   27 LECYCCLGVPlETSCKTMT-CPYSDGFCVTQEEEVIVDSHTiKVKSNLC--LPICPTNpETTEFLGNAVNVKTFCCKEDL 103
Cdd:smart00134   1 LQCYSCTGNP-DSSCSSEEeCRSPDDVCLTVVAEVISDSRG-SVVYKGCatSPICPGS-HGYEINLTIAFLKVSCCQTDL 77


                   ....*
gi 1720383943  104 CNAAV 108
Cdd:smart00134  78 CNAAG 82
TFP_LU_ECD_Ly6L cd23551
extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L ...
 27-107 8.90e-07

extracellular domain (ECD) found in lymphocyte antigen 6L (Ly-6L) and similar proteins; Ly-6L (also called lymphocyte antigen 6 complex locus protein L) contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467081  Cd Length: 86  Bit Score: 43.93  E-value: 8.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383943  27 LECYCCLGVPLETSCKTMTCPYSDGFCVTQEEEVIVDSHTIKVKSNLCLPICPTNPETTEF---LGNAVNVKTFCCKEDL 103
Cdd:cd23551     2 LKCYQCFKVSSDEDCKPDQCAPSEIVCISNEVVLYVGTKVRVLISKRCAPRCPNTNSRCEWspgTQVIGSITRTCCSQSL 81


                  ....
gi 1720383943 104 CNAA 107
Cdd:cd23551    82 CNRA 85
TFP_LU_ECD_GPIHBP1 cd23575
extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density ...
 27-106 5.45e-05

extracellular domain (ECD) found in glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) and similar proteins; GPI-HBP1 (also called GPI-anchored HDL-binding protein 1, or high density lipoprotein-binding protein 1) is an endothelial cell transporter for lipoprotein lipase. It mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries and anchors LPL on the surface of endothelial cells in the lumen of blood capillaries. GPI-HBP1 protects LPL against loss of activity, and against ANGPTL4-mediated unfolding. Thereby, it plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis. GPI-HBP1 binds chylomicrons and phospholipid particles that contain APOA5. It also binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL. GPI-HBP1 contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467105  Cd Length: 83  Bit Score: 39.24  E-value: 5.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383943  27 LECYCCLGVPLETSCKTMT-CPYSDGFCVTQEEEVIVDSHTIKVKSNLCLPICPTNPETTEFLGNAVNvktfCCKEDLCN 105
Cdd:cd23575     3 LKCYTCVSAHSNSDCLTETnCSSSDTYCKTLVASASGGSGSLTTITKWCASSCTPSTRTVEGTKVTVS----CCQTDLCN 78


                  .
gi 1720383943 106 A 106
Cdd:cd23575    79 V 79
TFP_LU_ECD_Ly6E cd23543
extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E ...
 27-105 1.04e-04

extracellular domain (ECD) found in lymphocyte antigen 6E (Ly-6E) and similar proteins; Ly-6E (also called retinoic acid-induced gene E protein (RIG-E), or stem cell antigen 2 (SCA-2), or thymic shared antigen 1 (TSA-1)) is a GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. It restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion. It plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). It may also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. Ly-6E contains an extracellular domain (ECD) which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467073  Cd Length: 78  Bit Score: 38.49  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720383943  27 LECYCCLGVPLETSCKTMT-CPYSDGFCVTQEEEV-IVDSHTIKVkSNLCLPICPTnpetTEFLGNAVNVKTFCCKEDLC 104
Cdd:cd23543     3 LYCYTCENQSSNWNCLKPTkCSDNDKYCVTTVASGgTGSSSGVRI-TKKCSPKCPE----TNVNIGIASVSTSCCQSSLC 77


                  .
gi 1720383943 105 N 105
Cdd:cd23543    78 N 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH