NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720397932|ref|XP_030104748|]
View 

solute carrier family 12 member 1 isoform X3 [Mus musculus]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
96-1122 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1499.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932   96 TMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVTVAPGSADRVANGDGMPGDEQAEN----KEEDMTGVVKFGWV 171
Cdd:TIGR00930    2 TVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGWV 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  172 KGVLVRCMLNIWGVMLFIRLSWIVGEAgiglgviiiglavtvtaitGLstsaiatngyvrgGLGVLIILLSTMVTSITGL 251
Cdd:TIGR00930   82 MGVLVPCLLNIWGVILFLRLSWIVGQA-------------------GI-------------GLSLLIILLCCCVTTITGL 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  252 STSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSI 330
Cdd:TIGR00930  130 SMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTV 209
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  331 TVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPSFTKGEG-FFSVFAI 409
Cdd:TIGR00930  210 TVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGI 288
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  410 FFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVAACVVRDATGSMNDTIVSgmnCNGSAACglgyd 489
Cdd:TIGR00930  289 FFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC----- 360
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  490 FSRCQHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLR 569
Cdd:TIGR00930  361 FSECAHNTCSYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLR 440
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  570 GYFLTFVIAMAFILIAELNVIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWW 649
Cdd:TIGR00930  441 AYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWW 520
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  650 AAVITYVIELFLYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTK 729
Cdd:TIGR00930  521 AALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTK 600
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  730 NSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWR 809
Cdd:TIGR00930  601 GKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWR 680
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  810 KAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISpVLQVQDELEkleqerlaleaaikdNECEEgkggirglfkkagk 889
Cdd:TIGR00930  681 QAEPRAWETYIGIIHDAFDAHLAVVVVRNSEGLPIS-VLQVQEELE---------------NDCSE-------------- 730
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  890 lnitKPAPKKDGNISSIQSMHvgefnqklVEASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVG 969
Cdd:TIGR00930  731 ----DSIELNDGKISTQPDMH--------LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVG 798
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  970 G-KINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESWKVFEEMIEPYRLHESHKDLTTAE-KLKRESPWKITDA 1047
Cdd:TIGR00930  799 AqKDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDA 878
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720397932 1048 ELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1122
Cdd:TIGR00930  879 ELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
96-1122 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1499.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932   96 TMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVTVAPGSADRVANGDGMPGDEQAEN----KEEDMTGVVKFGWV 171
Cdd:TIGR00930    2 TVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGWV 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  172 KGVLVRCMLNIWGVMLFIRLSWIVGEAgiglgviiiglavtvtaitGLstsaiatngyvrgGLGVLIILLSTMVTSITGL 251
Cdd:TIGR00930   82 MGVLVPCLLNIWGVILFLRLSWIVGQA-------------------GI-------------GLSLLIILLCCCVTTITGL 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  252 STSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSI 330
Cdd:TIGR00930  130 SMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTV 209
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  331 TVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPSFTKGEG-FFSVFAI 409
Cdd:TIGR00930  210 TVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGI 288
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  410 FFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVAACVVRDATGSMNDTIVSgmnCNGSAACglgyd 489
Cdd:TIGR00930  289 FFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC----- 360
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  490 FSRCQHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLR 569
Cdd:TIGR00930  361 FSECAHNTCSYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLR 440
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  570 GYFLTFVIAMAFILIAELNVIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWW 649
Cdd:TIGR00930  441 AYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWW 520
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  650 AAVITYVIELFLYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTK 729
Cdd:TIGR00930  521 AALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTK 600
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  730 NSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWR 809
Cdd:TIGR00930  601 GKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWR 680
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  810 KAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISpVLQVQDELEkleqerlaleaaikdNECEEgkggirglfkkagk 889
Cdd:TIGR00930  681 QAEPRAWETYIGIIHDAFDAHLAVVVVRNSEGLPIS-VLQVQEELE---------------NDCSE-------------- 730
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  890 lnitKPAPKKDGNISSIQSMHvgefnqklVEASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVG 969
Cdd:TIGR00930  731 ----DSIELNDGKISTQPDMH--------LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVG 798
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  970 G-KINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESWKVFEEMIEPYRLHESHKDLTTAE-KLKRESPWKITDA 1047
Cdd:TIGR00930  799 AqKDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDA 878
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720397932 1048 ELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1122
Cdd:TIGR00930  879 ELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
717-1122 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 604.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  717 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 796
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  797 PNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELE-KLEQERLALEAAIKDNECEE 875
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEElGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  876 GKGGIRGLFKKAGKLN--------ITKPAPKKDGNISSIQSMHVGEF--------NQKLVEASAQFKKKQGKGTIDVWWL 939
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDsnlslspdKSTKNPSGKDSSKSDKLKKKSPSiilrtasnEKEILNNITQFQKKQKKGTIDVWWL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  940 FDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESWKVFEEMI 1018
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932 1019 EPYRLHESHKDLttaeklkrESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLE 1098
Cdd:pfam03522  319 EPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390
                          410       420
                   ....*....|....*....|....
gi 1720397932 1099 ILTKNLPPVLLVRGNHKNVLTFYS 1122
Cdd:pfam03522  391 TLTKDLPPFLLVRGNQTSVLTFYS 414
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
210-672 2.52e-37

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 146.20  E-value: 2.52e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  210 AVTVTAITGLSTSAIATNGYVRGGLGVLI-ILLSTMVTSITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGSIGLIFA 288
Cdd:COG0531     20 ALGVGAIIGAGIFVLPGLAAGLAGPAAILaWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALL 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  289 FANAVAVAMYVVGFAETVVDLLkesdsmmvdPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGt 368
Cdd:COG0531     99 LSYVLAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV- 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  369 vipsnnekksrGFFNYQASIFAeNFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVA 448
Cdd:COG0531    169 -----------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVL 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  449 YIGVAICVAACVVRDATGSMNDTIvsgmncngsaacglgydfsrcqhepcqyglmnnFQVMSMVSG--FGPLITAGIFSA 526
Cdd:COG0531    237 YILVSLALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLS 283
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  527 TLSSALASLVSAPKVFQALCKDNIFkgLQFFAKGYGKNNEPLRGYFLTFVIAMAFILI--AELNVIAPIISNFFLASYAL 604
Cdd:COG0531    284 LLGALNASILGASRLLYAMARDGLL--PKVFAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLL 361
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720397932  605 INFSCFHASYaKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWA---AVITYVIELFLYIYVTYKKPDV 672
Cdd:COG0531    362 VALAVIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
96-1122 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1499.99  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932   96 TMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVTVAPGSADRVANGDGMPGDEQAEN----KEEDMTGVVKFGWV 171
Cdd:TIGR00930    2 TVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGWV 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  172 KGVLVRCMLNIWGVMLFIRLSWIVGEAgiglgviiiglavtvtaitGLstsaiatngyvrgGLGVLIILLSTMVTSITGL 251
Cdd:TIGR00930   82 MGVLVPCLLNIWGVILFLRLSWIVGQA-------------------GI-------------GLSLLIILLCCCVTTITGL 129
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  252 STSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSI 330
Cdd:TIGR00930  130 SMSAIATNGVVKGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTV 209
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  331 TVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPSFTKGEG-FFSVFAI 409
Cdd:TIGR00930  210 TVVVLLGISFAGMEWENKAQVLFLVIVLLSILNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGI 288
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  410 FFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVAACVVRDATGSMNDTIVSgmnCNGSAACglgyd 489
Cdd:TIGR00930  289 FFPSVTGILAGANISGDLKDPQKAIPKGTLLAILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC----- 360
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  490 FSRCQHEPCQYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLR 569
Cdd:TIGR00930  361 FSECAHNTCSYGLMNNLQVMSLVSPFPPLITAGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLR 440
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  570 GYFLTFVIAMAFILIAELNVIAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWW 649
Cdd:TIGR00930  441 AYLLTAFIAEGFILIAELNTIAPIISNFFLASYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWW 520
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  650 AAVITYVIELFLYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTK 729
Cdd:TIGR00930  521 AALVAMVIALFLYKYVTYKKPDVNWGSSTQALSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTK 600
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  730 NSGLCICCEVFVGPRKLCVKEMNSGMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWR 809
Cdd:TIGR00930  601 GKGLMICGSVIQGPRLECVKEAQAAEAKIQTWLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWR 680
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  810 KAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISpVLQVQDELEkleqerlaleaaikdNECEEgkggirglfkkagk 889
Cdd:TIGR00930  681 QAEPRAWETYIGIIHDAFDAHLAVVVVRNSEGLPIS-VLQVQEELE---------------NDCSE-------------- 730
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  890 lnitKPAPKKDGNISSIQSMHvgefnqklVEASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVG 969
Cdd:TIGR00930  731 ----DSIELNDGKISTQPDMH--------LEASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVG 798
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  970 G-KINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESWKVFEEMIEPYRLHESHKDLTTAE-KLKRESPWKITDA 1047
Cdd:TIGR00930  799 AqKDDRSEQEKKDMATLLYKFRIDAEVIVVLMDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDA 878
                          970       980       990      1000      1010      1020      1030
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720397932 1048 ELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1122
Cdd:TIGR00930  879 ELQSNVRKSYRQVRLNELLLEYSRDAALVVLSLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
717-1122 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 604.23  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  717 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLIKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 796
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  797 PNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELE-KLEQERLALEAAIKDNECEE 875
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEElGLGDETNSSYAEQSSEEQST 158
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  876 GKGGIRGLFKKAGKLN--------ITKPAPKKDGNISSIQSMHVGEF--------NQKLVEASAQFKKKQGKGTIDVWWL 939
Cdd:pfam03522  159 SNSKQDDDKSKLSKKDsnlslspdKSTKNPSGKDSSKSDKLKKKSPSiilrtasnEKEILNNITQFQKKQKKGTIDVWWL 238
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  940 FDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKESWKVFEEMI 1018
Cdd:pfam03522  239 YDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKETKKFFDELI 318
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932 1019 EPYRLHESHKDLttaeklkrESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISDLLYMAWLE 1098
Cdd:pfam03522  319 EPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSAPLYMAWLE 390
                          410       420
                   ....*....|....*....|....
gi 1720397932 1099 ILTKNLPPVLLVRGNHKNVLTFYS 1122
Cdd:pfam03522  391 TLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease pfam00324
Amino acid permease;
173-708 2.01e-118

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 373.58  E-value: 2.01e-118
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  173 GVLVRCMLNIWGVMLFIRLSWIVGEAGiglgviiiglavtvtaitglstsaiatngyvrGGLGVLIILLSTMVTSITGLS 252
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAG--------------------------------PAGALLGYLISGVVIFLVMLS 48
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  253 TSAIATNGFVrGGGAYYLISRSLGPEFGGSIGL------IFAFANAVAVAMYVVGFAETVVDLLKESdsmmvdptndirI 326
Cdd:pfam00324   49 LGEISTNGPV-SGGFYTYASRFLGPSLGFATGWnywlswITVLALELTAASILIQFWELVPDIPYLW------------V 115
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  327 IGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPSNNEKKSRG--FFNYQASIFAENFGPSFTKGegFF 404
Cdd:pfam00324  116 WGAVFLVLLTIINLVGVKWYGEAEFWFALIKIIAIIGFIIVGIILLSGGNPNDGaiFRYLGDNGGKNNFPPGFGKG--FI 193
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  405 SVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGVAICVAACVVRDATGSMNDTIVSgmncngsaac 484
Cdd:pfam00324  194 SVFVIAFFAFTGIELVGIAAGEVKNPEKSIPKAILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASA---------- 263
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  485 glgydfsrcqhepcqYGLMNNFQVMSMVSGFGPLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKglqFFAKGYGKN 564
Cdd:pfam00324  264 ---------------ASPFVIFFKFLGISGLAPLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKR 325
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  565 NEPLRGYFLTFVIAMAFILIAELNviAPIISNFFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMF 644
Cdd:pfam00324  326 GVPLRAILVSMVISLLALLLASLN--PAIVFNFLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLG 403
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720397932  645 VINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQALSYVSALDNALELTTVEDHVKNFRPQCI 708
Cdd:pfam00324  404 VILGLAAIIIILIIQFLYAFLPVPGGPKNWGAGSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
210-672 2.52e-37

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 146.20  E-value: 2.52e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  210 AVTVTAITGLSTSAIATNGYVRGGLGVLI-ILLSTMVTSITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGSIGLIFA 288
Cdd:COG0531     20 ALGVGAIIGAGIFVLPGLAAGLAGPAAILaWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALL 98
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  289 FANAVAVAMYVVGFAETVVDLLkesdsmmvdPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGt 368
Cdd:COG0531     99 LSYVLAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV- 168
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  369 vipsnnekksrGFFNYQASIFAeNFGPSFTKGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVA 448
Cdd:COG0531    169 -----------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVL 236
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  449 YIGVAICVAACVVRDATGSMNDTIvsgmncngsaacglgydfsrcqhepcqyglmnnFQVMSMVSG--FGPLITAGIFSA 526
Cdd:COG0531    237 YILVSLALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLS 283
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  527 TLSSALASLVSAPKVFQALCKDNIFkgLQFFAKGYGKNNEPLRGYFLTFVIAMAFILI--AELNVIAPIISNFFLASYAL 604
Cdd:COG0531    284 LLGALNASILGASRLLYAMARDGLL--PKVFAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLL 361
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720397932  605 INFSCFHASYaKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWA---AVITYVIELFLYIYVTYKKPDV 672
Cdd:COG0531    362 VALAVIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
AA_permease_N pfam08403
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
86-148 1.58e-29

Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.


Pssm-ID: 429977  Cd Length: 70  Bit Score: 112.15  E-value: 1.58e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932   86 DSHTNTYYLQ-----TMDAVPKIEYYRNTGSVSGPKVNRPSLLEIHEQLAKNVT--VAPGSADRVANGDG 148
Cdd:pfam08403    1 DTHGSTYYLQtfghnTLDAVPRIDFYRNTGSVSGVKKSRPSLAELHSQLKKNSAlaVAEGSVDGVENGDG 70
AA_permease_2 pfam13520
Amino acid permease;
210-652 3.30e-17

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 85.44  E-value: 3.30e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  210 AVTVTAITGlSTSAIATNGYVRGGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAF 289
Cdd:pfam13520    8 ALVIGSVIG-SGIFVAPLVASGGPALIVWGWIAAIIFSLAVGLVYAELSSALPRSGGIYVYLENAFGKFVAFLAGWSNWF 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  290 ANAVAVAMYVVGFAETVVDLLKESdsmMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTV 369
Cdd:pfam13520   87 AYVLGLASSASVAASYLLSALGPD---LVPTTWLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLILIIILG 163
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  370 IPsnneKKSRGFFNYqASIFAENFGPSFTKGegFFSVFAIFFPAATGILAGANISGdlEDPQDAIPRGTMLAIFITTVAY 449
Cdd:pfam13520  164 LV----TADGGGFNL-LSGEWHTFFPDGWPG--VFAGFLGVLWSFTGFESAANVSE--EVKKRNVPKAIFIGVIIVGVLY 234
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  450 IGVAICVAACVVRDATGSMNDTIVSGmncngsaacglgydfsrcqhepcqyGLMNNFQVMSMVSGFgplITAGIFSATLS 529
Cdd:pfam13520  235 ILVNIAFFGVVPDDEIALSSGLGQVA-------------------------ALLFQAVGGKWGAII---VVILLALSLLG 286
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720397932  530 SALASLVSAPKVFQALCKDNIFKGLQFFAKgYGKNNEPLRGYFLTFVIAMAFILI-----AELNVIAPIISNFFLASYAL 604
Cdd:pfam13520  287 AVNTAIVGASRLLYALARDGVLPFSRFFAK-VNKFGSPIRAIILTAILSLILLLLfllspAAYNALLSLSAYGYLLSYLL 365
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|....*...
gi 1720397932  605 INFSCFHASYAKSPGWRpaygIYNMWVSLFGAILCCAVMFVINWWAAV 652
Cdd:pfam13520  366 PIIGLLILRKKRPDLGR----IPGRWPVAIFGILFSLFLIVALFFPPV 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH