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Conserved domains on  [gi|1720386377|ref|XP_030104810|]
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chordin isoform X11 [Mus musculus]

Protein Classification

follistatin-related protein 1( domain architecture ID 10654732)

follistatin-related protein 1 is an extracellular calcium-binding protein belonging to the BM-40/SPARC/osteonectin family and containing Kazal-type serine protease inhibitor/follistatin-like and EF-hand domains, that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
34-151 1.77e-26

A domain in the BMP inhibitor chordin and in microbial proteins;


:

Pssm-ID: 214804  Cd Length: 118  Bit Score: 103.97  E-value: 1.77e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377   34 DVLQSVLCGADALIPVQTGAAGSASFILLGNGSLIYQVQVVGTGSEVVAMTLETKPQRKN---QRTVLCHMaglQPGGHM 110
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPETAAHIHEGEIGTNgpvVRIPLPNP---TSREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1720386377  111 AVGMCSGLGARGAHMLLQNELFLNVGTKDFPDGELRGHVTA 151
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVAK 118
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
164-276 2.07e-26

A domain in the BMP inhibitor chordin and in microbial proteins;


:

Pssm-ID: 214804  Cd Length: 118  Bit Score: 103.97  E-value: 2.07e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377  164 LPVPLAGALVLPPVRSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQgtvTAHL-LGPPGMPGPQR--LLKGF--YGSEAQ 238
Cdd:smart00754   3 FSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPET---AAHIhEGEIGTNGPVVriPLPNPtsREGPFA 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1720386377  239 GVVKDLEPVLLRHLAQGTASLLITTKSSPRGELRGQVH 276
Cdd:smart00754  80 GSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
VWC smart00214
von Willebrand factor (vWF) type C domain;
413-479 3.99e-06

von Willebrand factor (vWF) type C domain;


:

Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.43  E-value: 3.99e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720386377  413 CYFDGDrsWRAAGTRWHPVVppfglikCAVCTCKGATgEVHCEKVQCPR-LACAQPVRANPTD-CCKQC 479
Cdd:smart00214   1 CVHNGR--VYNDGETWKPDP-------CQICTCLDGT-TVLCDPVECPPpPDCPNPERVKPPGeCCPRC 59
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 501-561 9.66e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.40  E-value: 9.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720386377 501 CRFAGQWFPENQSWHPSvppfgemSCITCRCGAGVPHCERDDCsPPLSCGSGKES----RCCSHC 561
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIIC-PPLDCPNPRLEippgECCPVC 57
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 335-392 6.87e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 35.09  E-value: 6.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377 335 CFFEGQQRPHGARWAPNydpLCSLCICQRRTVICDPVVCPPPSCPHP--VQALDQCCPVC 392
Cdd:pfam00093   1 CVQNGVVYENGETWKPD---LCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
 
Name Accession Description Interval E-value
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
34-151 1.77e-26

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 103.97  E-value: 1.77e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377   34 DVLQSVLCGADALIPVQTGAAGSASFILLGNGSLIYQVQVVGTGSEVVAMTLETKPQRKN---QRTVLCHMaglQPGGHM 110
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPETAAHIHEGEIGTNgpvVRIPLPNP---TSREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1720386377  111 AVGMCSGLGARGAHMLLQNELFLNVGTKDFPDGELRGHVTA 151
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVAK 118
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
164-276 2.07e-26

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 103.97  E-value: 2.07e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377  164 LPVPLAGALVLPPVRSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQgtvTAHL-LGPPGMPGPQR--LLKGF--YGSEAQ 238
Cdd:smart00754   3 FSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPET---AAHIhEGEIGTNGPVVriPLPNPtsREGPFA 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1720386377  239 GVVKDLEPVLLRHLAQGTASLLITTKSSPRGELRGQVH 276
Cdd:smart00754  80 GSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 164-275 1.16e-14

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 70.59  E-value: 1.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377 164 LPVPLAGALVLPP-VRSQAAGHAWLSLDTHCH-LHYEVLLAGLggseQGTVTAHL-LGPPGMPGPQRL-----LKGFYGS 235
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLDDTENtLHYTLTFSGL----SVPTAAHIhAGAAGFNGPVVVpleggPRKTTLL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720386377 236 EAQGVVKDLEPVLLRHLAQGTASLLIT--TKSSPRGELRGQV 275
Cdd:pfam07452  77 AVPEGLATLTAAQLAALLAQQGELYVNvhTEGNPGGEIRGQI 118
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 36-149 2.29e-12

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 64.04  E-value: 2.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377  36 LQSVLCGADALIP-VQTGAAGSASFIL-LGNGSLIYQVQVVGTG--------------SEVVAMTLETKPQRKNQRTVlc 99
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLdDTENTLHYTLTFSGLSvptaahihagaagfNGPVVVPLEGGPRKTTLLAV-- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720386377 100 hmaglqpgghmaVGMCSGLGARGAHMLLQN--ELFLNVGTKDFPDGELRGHV 149
Cdd:pfam07452  79 ------------PEGLATLTAAQLAALLAQqgELYVNVHTEGNPGGEIRGQI 118
VWC smart00214
von Willebrand factor (vWF) type C domain;
413-479 3.99e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.43  E-value: 3.99e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720386377  413 CYFDGDrsWRAAGTRWHPVVppfglikCAVCTCKGATgEVHCEKVQCPR-LACAQPVRANPTD-CCKQC 479
Cdd:smart00214   1 CVHNGR--VYNDGETWKPDP-------CQICTCLDGT-TVLCDPVECPPpPDCPNPERVKPPGeCCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 501-561 9.66e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 9.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720386377 501 CRFAGQWFPENQSWHPSvppfgemSCITCRCGAGVPHCERDDCsPPLSCGSGKES----RCCSHC 561
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIIC-PPLDCPNPRLEippgECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 335-392 6.87e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 35.09  E-value: 6.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377 335 CFFEGQQRPHGARWAPNydpLCSLCICQRRTVICDPVVCPPPSCPHP--VQALDQCCPVC 392
Cdd:pfam00093   1 CVQNGVVYENGETWKPD---LCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
 
Name Accession Description Interval E-value
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
34-151 1.77e-26

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 103.97  E-value: 1.77e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377   34 DVLQSVLCGADALIPVQTGAAGSASFILLGNGSLIYQVQVVGTGSEVVAMTLETKPQRKN---QRTVLCHMaglQPGGHM 110
Cdd:smart00754   1 ETFSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPETAAHIHEGEIGTNgpvVRIPLPNP---TSREGP 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1720386377  111 AVGMCSGLGARGAHMLLQNELFLNVGTKDFPDGELRGHVTA 151
Cdd:smart00754  78 FAGSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVAK 118
CHRD smart00754
A domain in the BMP inhibitor chordin and in microbial proteins;
164-276 2.07e-26

A domain in the BMP inhibitor chordin and in microbial proteins;


Pssm-ID: 214804  Cd Length: 118  Bit Score: 103.97  E-value: 2.07e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377  164 LPVPLAGALVLPPVRSQAAGHAWLSLDTHCHLHYEVLLAGLGGSEQgtvTAHL-LGPPGMPGPQR--LLKGF--YGSEAQ 238
Cdd:smart00754   3 FSALLTGSQEVPPVNTGAVGGAWFTLDDDGSLHYQVTLSGLSGPET---AAHIhEGEIGTNGPVVriPLPNPtsREGPFA 79

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1720386377  239 GVVKDLEPVLLRHLAQGTASLLITTKSSPRGELRGQVH 276
Cdd:smart00754  80 GSVKTLTDEELRQLLAGNLYVNVHTKANPGGEIRGQVA 117
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 164-275 1.16e-14

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 70.59  E-value: 1.16e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377 164 LPVPLAGALVLPP-VRSQAAGHAWLSLDTHCH-LHYEVLLAGLggseQGTVTAHL-LGPPGMPGPQRL-----LKGFYGS 235
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLDDTENtLHYTLTFSGL----SVPTAAHIhAGAAGFNGPVVVpleggPRKTTLL 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1720386377 236 EAQGVVKDLEPVLLRHLAQGTASLLIT--TKSSPRGELRGQV 275
Cdd:pfam07452  77 AVPEGLATLTAAQLAALLAQQGELYVNvhTEGNPGGEIRGQI 118
CHRD pfam07452
CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in ...
 36-149 2.29e-12

CHRD domain; CHRD (after SWISS-PROT abbreviation for chordin) is a novel domain identified in chordin, an inhibitor of bone morphogenetic proteins. This family includes bacterial homologs. It is anticipated to have an immunoglobulin-like beta-barrel structure based on limited similarity to superoxide dismutases but, as yet, no clear functional prediction can be made. Its most conserved feature is a GE[I/L]RCG[V/I/L] motif towards its C-terminal end Most bacterial proteins in this family have only one CHRD domain, whereas it is found repeated in many eukaryotic proteins such as human chordin and Drosophila SOG..


Pssm-ID: 462167  Cd Length: 118  Bit Score: 64.04  E-value: 2.29e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377  36 LQSVLCGADALIP-VQTGAAGSASFIL-LGNGSLIYQVQVVGTG--------------SEVVAMTLETKPQRKNQRTVlc 99
Cdd:pfam07452   1 FSALLTGAQEVPPpVTTGAGGTAVLTLdDTENTLHYTLTFSGLSvptaahihagaagfNGPVVVPLEGGPRKTTLLAV-- 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720386377 100 hmaglqpgghmaVGMCSGLGARGAHMLLQN--ELFLNVGTKDFPDGELRGHV 149
Cdd:pfam07452  79 ------------PEGLATLTAAQLAALLAQqgELYVNVHTEGNPGGEIRGQI 118
VWC smart00214
von Willebrand factor (vWF) type C domain;
413-479 3.99e-06

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 44.43  E-value: 3.99e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720386377  413 CYFDGDrsWRAAGTRWHPVVppfglikCAVCTCKGATgEVHCEKVQCPR-LACAQPVRANPTD-CCKQC 479
Cdd:smart00214   1 CVHNGR--VYNDGETWKPDP-------CQICTCLDGT-TVLCDPVECPPpPDCPNPERVKPPGeCCPRC 59
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 501-561 9.66e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.40  E-value: 9.66e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720386377 501 CRFAGQWFPENQSWHPSvppfgemSCITCRCGAGVPHCERDDCsPPLSCGSGKES----RCCSHC 561
Cdd:pfam00093   1 CVQNGVVYENGETWKPD-------LCTICTCDDGKVLCDKIIC-PPLDCPNPRLEippgECCPVC 57
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 335-392 6.87e-03

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 35.09  E-value: 6.87e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720386377 335 CFFEGQQRPHGARWAPNydpLCSLCICQRRTVICDPVVCPPPSCPHP--VQALDQCCPVC 392
Cdd:pfam00093   1 CVQNGVVYENGETWKPD---LCTICTCDDGKVLCDKIICPPLDCPNPrlEIPPGECCPVC 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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