transcription initiation protein SPT3 homolog isoform X1 [Mus musculus]
Protein Classification
TATA binding protein associated factor 13( domain architecture ID 7054)
TATA binding protein (TBP) associated factor 13 (TAF13) is one of several TAFs that bind TBP and are involved in forming Transcription Factor IID (TFIID) complex. TAF13 interacts with TAF11 and makes a histone-like heterodimer similar to H3/H4-like proteins. The dimer may be structurally and functionally similar to the spt3 protein within the SAGA histone acetyltransferase complex.
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| HFD_SF super family | cl45933 | histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally ... |
1-30 | 6.08e-07 | ||
histone fold domain (HFD) superfamily; The histone fold domain (HFD) is a structurally conserved interaction motif involved in heterodimerization of the core histones and their assembly into the nucleosome octamer. Histone fold heterodimers play crucial roles in gene regulation. The minimal HFD consists of three alpha helices connected by two short, unstructured loops. The HFD is found in core histones, TATA box-binding protein-associated factors (TAFs), and many other transcription factors. HFD plays a role in the nucleosomal core particle by conserving histone interactions; these contain more than one HFD. The structure of the nucleosome core particle has two modes that have the largest interaction surfaces, and these are the H3-H4 and H2A-H2B heterodimer interactions. Several TAFs interact via histone-fold (HF) motifs. Five HF-containing TAF pairs have been described in transcription factor II D (TFIID): TAF6-TAF9, TAF4-TAF12, TAF11-TAF13, TAF8-TAF10 and TAF3-TAF10. The actual alignment was detected with superfamily member pfam02269: Pssm-ID: 480273 Cd Length: 93 Bit Score: 46.65 E-value: 6.08e-07
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| Name | Accession | Description | Interval | E-value | ||
| TFIID-18kDa | pfam02269 | Transcription initiation factor IID, 18kD subunit; This family includes the Spt3 yeast ... |
1-30 | 6.08e-07 | ||
Transcription initiation factor IID, 18kD subunit; This family includes the Spt3 yeast transcription factors and the 18kD subunit from human transcription initiation factor IID (TFIID-18). Determination of the crystal structure reveals an atypical histone fold Pssm-ID: 190265 Cd Length: 93 Bit Score: 46.65 E-value: 6.08e-07
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| Name | Accession | Description | Interval | E-value | ||
| TFIID-18kDa | pfam02269 | Transcription initiation factor IID, 18kD subunit; This family includes the Spt3 yeast ... |
1-30 | 6.08e-07 | ||
Transcription initiation factor IID, 18kD subunit; This family includes the Spt3 yeast transcription factors and the 18kD subunit from human transcription initiation factor IID (TFIID-18). Determination of the crystal structure reveals an atypical histone fold Pssm-ID: 190265 Cd Length: 93 Bit Score: 46.65 E-value: 6.08e-07
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