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Conserved domains on  [gi|1720390522|ref|XP_030105746|]
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THO complex subunit 6 homolog isoform X1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
31-287 1.11e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 1.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522  31 SVSPCGKFLAAGNNYGQIAIFSLsaalsseakeESKKPVVVFHAHDGPVYSM-VSTD-RHLLSAG-DGEVKgwLWaeilk 107
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDL----------ATGKLLRTLTGHSGAVTSVaFSPDgKLLASGSdDGTVR--LW----- 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 108 kgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHSMDLETGAFTRALRGHTDYIHCLALrerSPE---VL 184
Cdd:COG2319   190 ----DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrlLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 185 SGGEDGAVRLWDLRIAKEVQTIEvykheecsrpHNGRWIGCLAT--DSDWMVCGGG-PALTLWHLRSSTPTTVFPI-RAP 260
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLT----------GHSGGVNSVAFspDGKLLASGSDdGTVRLWDLATGKLLRTLTGhTGA 332

                         250       260
                  ....*....|....*....|....*....
gi 1720390522 261 QKHVTFYQD--LILSAGQGCCVNHWQLSG 287
Cdd:COG2319   333 VRSVAFSPDgkTLASGSDDGTVRLWDLAT 361
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
31-287 1.11e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 1.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522  31 SVSPCGKFLAAGNNYGQIAIFSLsaalsseakeESKKPVVVFHAHDGPVYSM-VSTD-RHLLSAG-DGEVKgwLWaeilk 107
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDL----------ATGKLLRTLTGHSGAVTSVaFSPDgKLLASGSdDGTVR--LW----- 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 108 kgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHSMDLETGAFTRALRGHTDYIHCLALrerSPE---VL 184
Cdd:COG2319   190 ----DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrlLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 185 SGGEDGAVRLWDLRIAKEVQTIEvykheecsrpHNGRWIGCLAT--DSDWMVCGGG-PALTLWHLRSSTPTTVFPI-RAP 260
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLT----------GHSGGVNSVAFspDGKLLASGSDdGTVRLWDLATGKLLRTLTGhTGA 332

                         250       260
                  ....*....|....*....|....*....
gi 1720390522 261 QKHVTFYQD--LILSAGQGCCVNHWQLSG 287
Cdd:COG2319   333 VRSVAFSPDgkTLASGSDDGTVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-196 7.64e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 7.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522  31 SVSPCGKFLAAGNNYGQIAIFSLsaalsseakeESKKPVVVFHAHDGPVYSM-VSTD--RHLLSAGDGEVKgwLWaEILK 107
Cdd:cd00200   142 AFSPDGTFVASSSQDGTIKLWDL----------RTGKCVATLTGHTGEVNSVaFSPDgeKLLSSSSDGTIK--LW-DLST 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 108 KGCKELWRRQPPYrtslevpeINALLLVPKENSLILAGGDCQLHSMDLETGAFTRALRGHTDYIHCLALRERSPEVLSGG 187
Cdd:cd00200   209 GKCLGTLRGHENG--------VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                  ....*....
gi 1720390522 188 EDGAVRLWD 196
Cdd:cd00200   281 ADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 2.91e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.91e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720390522  157 TGAFTRALRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-196 2.05e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.05e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720390522 158 GAFTRALRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
31-287 1.11e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 1.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522  31 SVSPCGKFLAAGNNYGQIAIFSLsaalsseakeESKKPVVVFHAHDGPVYSM-VSTD-RHLLSAG-DGEVKgwLWaeilk 107
Cdd:COG2319   127 AFSPDGKTLASGSADGTVRLWDL----------ATGKLLRTLTGHSGAVTSVaFSPDgKLLASGSdDGTVR--LW----- 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 108 kgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHSMDLETGAFTRALRGHTDYIHCLALrerSPE---VL 184
Cdd:COG2319   190 ----DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF---SPDgrlLA 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 185 SGGEDGAVRLWDLRIAKEVQTIEvykheecsrpHNGRWIGCLAT--DSDWMVCGGG-PALTLWHLRSSTPTTVFPI-RAP 260
Cdd:COG2319   263 SGSADGTVRLWDLATGELLRTLT----------GHSGGVNSVAFspDGKLLASGSDdGTVRLWDLATGKLLRTLTGhTGA 332

                         250       260
                  ....*....|....*....|....*....
gi 1720390522 261 QKHVTFYQD--LILSAGQGCCVNHWQLSG 287
Cdd:COG2319   333 VRSVAFSPDgkTLASGSDDGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
31-248 8.64e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.42  E-value: 8.64e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522  31 SVSPCGKFLAAGNNYGQIAIFSLsaalsseakeESKKPVVVFHAHDGPVYSMV-STD-RHLLSAG-DGEVKGWlwaeilk 107
Cdd:COG2319   211 AFSPDGKLLASGSADGTVRLWDL----------ATGKLLRTLTGHSGSVRSVAfSPDgRLLASGSaDGTVRLW------- 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 108 kgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHSMDLETGAFTRALRGHTDYIHCLALRERSPEVLSGG 187
Cdd:COG2319   274 ----DLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGS 349

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720390522 188 EDGAVRLWDLRIAKEVQTIevykheecsRPHNGrWIGCLA--TDSDWMVCGGGP-ALTLWHLRS 248
Cdd:COG2319   350 DDGTVRLWDLATGELLRTL---------TGHTG-AVTSVAfsPDGRTLASGSADgTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
27-198 9.88e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 9.88e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522  27 IFSQSVSPCGKFLAAGNNYGQIAIFSLsaalsseakeESKKPVVVFHAHDGPVYSMV-STD-RHLLSAG-DGEVKgwLWa 103
Cdd:COG2319   249 VRSVAFSPDGRLLASGSADGTVRLWDL----------ATGELLRTLTGHSGGVNSVAfSPDgKLLASGSdDGTVR--LW- 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 104 eilkkgckELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHSMDLETGAFTRALRGHTDYIHCLALRERSPEV 183
Cdd:COG2319   316 --------DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTL 387

                         170
                  ....*....|....*
gi 1720390522 184 LSGGEDGAVRLWDLR 198
Cdd:COG2319   388 ASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 31-196 7.64e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.05  E-value: 7.64e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522  31 SVSPCGKFLAAGNNYGQIAIFSLsaalsseakeESKKPVVVFHAHDGPVYSM-VSTD--RHLLSAGDGEVKgwLWaEILK 107
Cdd:cd00200   142 AFSPDGTFVASSSQDGTIKLWDL----------RTGKCVATLTGHTGEVNSVaFSPDgeKLLSSSSDGTIK--LW-DLST 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 108 KGCKELWRRQPPYrtslevpeINALLLVPKENSLILAGGDCQLHSMDLETGAFTRALRGHTDYIHCLALRERSPEVLSGG 187
Cdd:cd00200   209 GKCLGTLRGHENG--------VNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                  ....*....
gi 1720390522 188 EDGAVRLWD 196
Cdd:cd00200   281 ADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 27-285 8.39e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 8.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522  27 IFSQSVSPCGKFLAAGNNYGQIAIFSLsaalsseakeESKKPVVVFHAHDGPVYSMVSTDRH--LLSAG-DGEVKGWlwa 103
Cdd:cd00200    12 VTCVAFSPDGKLLATGSGDGTIKVWDL----------ETGELLRTLKGHTGPVRDVAASADGtyLASGSsDKTIRLW--- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 104 eILKKGCKelwrrqppyRTSLE--VPEINALLLVPKeNSLILAGG-DCQLHSMDLETGAFTRALRGHTDYIHCLALRERS 180
Cdd:cd00200    79 -DLETGEC---------VRTLTghTSYVSSVAFSPD-GRILSSSSrDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 181 PEVLSGGEDGAVRLWDLRIAKEVQTIEvykheecsrPHNGrWIGCLATDSDW---MVCGGGPALTLWHLRSSTPTTVF-- 255
Cdd:cd00200   148 TFVASSSQDGTIKLWDLRTGKCVATLT---------GHTG-EVNSVAFSPDGeklLSSSSDGTIKLWDLSTGKCLGTLrg 217

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1720390522 256 ---PIRApqkhVTFYQD--LILSAGQGCCVNHWQL 285
Cdd:cd00200   218 henGVNS----VAFSPDgyLLASGSEDGTIRVWDL 248
WD40 COG2319
WD40 repeat [General function prediction only];
47-256 1.06e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 65.32  E-value: 1.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522  47 QIAIFSLSAALSSEAKEESKKPVVVFHAHDGPVYSMVSTDRHLLSAGDGEVKGWLWAeilkkgckeLWRRQPPYRTSLEV 126
Cdd:COG2319     8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLD---------AAAGALLATLLGHT 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 127 PEINALLLVPKENSLILAGGDCQLHSMDLETGAFTRALRGHTDYIHCLALrerSPE---VLSGGEDGAVRLWDLRIAKEV 203
Cdd:COG2319    79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAF---SPDgktLASGSADGTVRLWDLATGKLL 155

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720390522 204 QTIevykheecsRPHNGrWIGCLA--TDSDWMVCGGG-PALTLWHLRSSTPTTVFP 256
Cdd:COG2319   156 RTL---------TGHSG-AVTSVAfsPDGKLLASGSDdGTVRLWDLATGKLLRTLT 201
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 161-285 1.17e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.34  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522 161 TRALRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRIAKEVQTIEVykHEecsrpHNGRWIGCLAtDSDWMVCGGGP- 239
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG--HT-----GPVRDVAASA-DGTYLASGSSDk 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720390522 240 ALTLWHLRSSTPTTVF-----PIRApqkhVTFYQD--LILSAGQGCCVNHWQL 285
Cdd:cd00200    74 TIRLWDLETGECVRTLtghtsYVSS----VAFSPDgrILSSSSRDKTIKVWDV 122
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 157-196 2.91e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.46  E-value: 2.91e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1720390522  157 TGAFTRALRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
158-196 2.05e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.05e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1720390522 158 GAFTRALRGHTDYIHCLALRERSPEVLSGGEDGAVRLWD 196
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
11-100 1.26e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 40.28  E-value: 1.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720390522  11 LGQAEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLsaalsseakeESKKPVVVFHAHDGPVYSMV-STD-RH 88
Cdd:COG2319   317 LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL----------ATGELLRTLTGHTGAVTSVAfSPDgRT 386

                          90
                  ....*....|...
gi 1720390522  89 LLSAG-DGEVKGW 100
Cdd:COG2319   387 LASGSaDGTVRLW 399
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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