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Conserved domains on  [gi|1720398524|ref|XP_030105879|]
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rab9 effector protein with kelch motifs isoform X4 [Mus musculus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 13818857)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
57-296 2.54e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.12  E-value: 2.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  57 TWSTpevTGSPPSPRTfHTSSAAIGNQLYVFGG--GERGAQPVEdvklhVFDANTLTWSQpeTHGSPPSPRHGHVMVAAG 134
Cdd:COG3055     2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGlsGGSASNSFE-----VYDPATNTWSE--LAPLPGPPRHHAAAVAQD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524 135 TKLFIHGGLAGDK----FFDDLHCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQ 210
Cdd:COG3055    71 GKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524 211 HWTVLqfdTSLPAGRLDHSMCVIPwpvmstsenkdSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLL----CFVFG 286
Cdd:COG3055   148 TWTQL---APLPTPRDHLAAAVLP-----------DGKILVIGGRNGSGFSNTWTTLAPLPTARAGHAAAVlggkILVFG 213

                         250
                  ....*....|...
gi 1720398524 287 GM---NTEGEVYD 296
Cdd:COG3055   214 GEsgfSDEVEAYD 226
Kelch_3 pfam13415
Galactose oxidase, central domain;
32-79 1.41e-03

Galactose oxidase, central domain;


:

Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 1.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720398524  32 HSIWVFGGADQSGNR--NCLQVMSPDR-TWSTpevTGSPPSPRTFHTSSAA 79
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrlNDLYVYDLDTnTWTQ---IGDLPPPRSGHSATYI 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
57-296 2.54e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.12  E-value: 2.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  57 TWSTpevTGSPPSPRTfHTSSAAIGNQLYVFGG--GERGAQPVEdvklhVFDANTLTWSQpeTHGSPPSPRHGHVMVAAG 134
Cdd:COG3055     2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGlsGGSASNSFE-----VYDPATNTWSE--LAPLPGPPRHHAAAVAQD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524 135 TKLFIHGGLAGDK----FFDDLHCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQ 210
Cdd:COG3055    71 GKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524 211 HWTVLqfdTSLPAGRLDHSMCVIPwpvmstsenkdSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLL----CFVFG 286
Cdd:COG3055   148 TWTQL---APLPTPRDHLAAAVLP-----------DGKILVIGGRNGSGFSNTWTTLAPLPTARAGHAAAVlggkILVFG 213

                         250
                  ....*....|...
gi 1720398524 287 GM---NTEGEVYD 296
Cdd:COG3055   214 GEsgfSDEVEAYD 226
PLN02193 PLN02193
nitrile-specifier protein
 58-226 7.65e-16

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 77.30  E-value: 7.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  58 WSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVeDVKLHVFDANTLTWS-QPETHGSPPSPRHGHVMVAAGTK 136
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524 137 LFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWtvlq 216
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                         170
                  ....*....|
gi 1720398524 217 FDTSLPAGRL 226
Cdd:PLN02193  307 FHCSTPGDSF 316
Kelch_3 pfam13415
Galactose oxidase, central domain;
81-133 3.56e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.43  E-value: 3.56e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720398524  81 GNQLYVFGGGERGAQPVEDvKLHVFDANTLTWSQPethGSPPSPRHGHVMVAA 133
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
32-79 1.41e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 1.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720398524  32 HSIWVFGGADQSGNR--NCLQVMSPDR-TWSTpevTGSPPSPRTFHTSSAA 79
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrlNDLYVYDLDTnTWTQ---IGDLPPPRSGHSATYI 49
Kelch smart00612
Kelch domain;
188-233 2.30e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 2.30e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1720398524  188 YMFGGMTATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHSMCVI 233
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
57-296 2.54e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.12  E-value: 2.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  57 TWSTpevTGSPPSPRTfHTSSAAIGNQLYVFGG--GERGAQPVEdvklhVFDANTLTWSQpeTHGSPPSPRHGHVMVAAG 134
Cdd:COG3055     2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGlsGGSASNSFE-----VYDPATNTWSE--LAPLPGPPRHHAAAVAQD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524 135 TKLFIHGGLAGDK----FFDDLHCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQ 210
Cdd:COG3055    71 GKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524 211 HWTVLqfdTSLPAGRLDHSMCVIPwpvmstsenkdSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLL----CFVFG 286
Cdd:COG3055   148 TWTQL---APLPTPRDHLAAAVLP-----------DGKILVIGGRNGSGFSNTWTTLAPLPTARAGHAAAVlggkILVFG 213

                         250
                  ....*....|...
gi 1720398524 287 GM---NTEGEVYD 296
Cdd:COG3055   214 GEsgfSDEVEAYD 226
PLN02193 PLN02193
nitrile-specifier protein
 58-226 7.65e-16

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 77.30  E-value: 7.65e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  58 WSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVeDVKLHVFDANTLTWS-QPETHGSPPSPRHGHVMVAAGTK 136
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524 137 LFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWtvlq 216
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                         170
                  ....*....|
gi 1720398524 217 FDTSLPAGRL 226
Cdd:PLN02193  307 FHCSTPGDSF 316
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
2-198 1.36e-15

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 75.19  E-value: 1.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524   2 DLGTHQWdTATREGLLPRYEHASFLPScspHSIWVFGGADQSGNRNCLQVMSPD-RTWSTpevTGSPPSPRTFHTSSAAI 80
Cdd:COG3055    96 DPATNTW-TKLAPMPTPRGGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPAtGTWTQ---LAPLPTPRDHLAAAVLP 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  81 GNQLYVFGGGErgaqpvedvklhvFDANTLTWSQPETHgspPSPRHGHVMVAAGTKLFIHGGLAGdkFFDDLHCIDIGDM 160
Cdd:COG3055   169 DGKILVIGGRN-------------GSGFSNTWTTLAPL---PTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATN 230

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1720398524 161 SWQKLGPtgaVPVGCAAHAAVAVGHHVYMFGGMTATGA 198
Cdd:COG3055   231 TWTALGE---LPTPRHGHAAVLTDGKVYVIGGETKPGV 265
PLN02153 PLN02153
epithiospecifier protein
 65-207 3.46e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 71.94  E-value: 3.46e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  65 GSPPSPRTFHtSSAAIGNQLYVFGGgERGAQPVEDVKLHVFDANTLTWSQPETHGSPPS-PRHGHVMVAAGTKLFIHGGL 143
Cdd:PLN02153   17 GKGPGPRCSH-GIAVVGDKLYSFGG-ELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGR 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720398524 144 AGDKFFDDLHCIDIGDMSWQ---KLGPTGAvPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHT 207
Cdd:PLN02153   95 DEKREFSDFYSYDTVKNEWTfltKLDEEGG-PEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRT 160
PLN02193 PLN02193
nitrile-specifier protein
 2-195 1.40e-07

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 52.27  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524   2 DLGTHQWDTATREGLLPryeHASFLPSCS---PHSIWVFGGADQSGNRNCLqvMSPDRT---WS--TPEVTGspPSPRTF 73
Cdd:PLN02193  199 DLETRTWSISPATGDVP---HLSCLGVRMvsiGSTLYVFGGRDASRQYNGF--YSFDTTtneWKllTPVEEG--PTPRSF 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  74 HtSSAAIGNQLYVFGGgeRGAQpvedVKLHVFDANTL---TWSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLAGDKFfD 150
Cdd:PLN02193  272 H-SMAADEENVYVFGG--VSAT----ARLKTLDSYNIvdkKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEV-D 343

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1720398524 151 DLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTA 195
Cdd:PLN02193  344 DVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGGEIA 388
Kelch_3 pfam13415
Galactose oxidase, central domain;
81-133 3.56e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.43  E-value: 3.56e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720398524  81 GNQLYVFGGGERGAQPVEDvKLHVFDANTLTWSQPethGSPPSPRHGHVMVAA 133
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
77-156 1.43e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.16  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  77 SAAIGNQLYVFGGGERGA-----QPVEDVklHVFDANTLTWSQPETHgsppSPRH--GHVMVAA-GTKLFIHGGLAG--- 145
Cdd:PRK14131   80 AAFIDGKLYVFGGIGKTNsegspQVFDDV--YKYDPKTNSWQKLDTR----SPVGlaGHVAVSLhNGKAYITGGVNKnif 153

                          90
                  ....*....|.
gi 1720398524 146 DKFFDDLHCID 156
Cdd:PRK14131  154 DGYFEDLAAAG 164
Kelch_6 pfam13964
Kelch motif;
70-125 2.75e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.78  E-value: 2.75e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720398524  70 PRTFHtSSAAIGNQLYVFGGGERGAQPVEdvKLHVFDANTLTWsqpETHGSPPSPR 125
Cdd:pfam13964   1 PRTFH-SVVSVGGYIYVFGGYTNASPALN--KLEVYNPLTKSW---EELPPLPTPR 50
PLN02153 PLN02153
epithiospecifier protein
 2-192 1.76e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 42.67  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524   2 DLGTHQWDTATREGLLPRYEHASFLPSCSPHSIWVFGGADQsgNRNCLQVMSPD---RTW---STPEVTGSPPSpRTFHt 75
Cdd:PLN02153   56 DFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGGRDE--KREFSDFYSYDtvkNEWtflTKLDEEGGPEA-RTFH- 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  76 SSAAIGNQLYVFGGGERGAQPVEDVKLHVFDANTLT---WSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLA-------- 144
Cdd:PLN02153  132 SMASDENHVYVFGGVSKGGLMKTPERFRTIEAYNIAdgkWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFAtsilpggk 211

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1720398524 145 GDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGG 192
Cdd:PLN02153  212 SDYESNAVQFFDPASGKWTEVETTGAKPSARSVFAHAVVGKYIIIFGG 259
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 122-153 3.09e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.54  E-value: 3.09e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720398524 122 PSPRHGHVMVAAGTKLFIHGG--LAGDKFFDDLH 153
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGytGGEGQPSDDVY 34
PLN02772 PLN02772
guanylate kinase
 76-147 6.65e-04

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 40.98  E-value: 6.65e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720398524  76 SSAAIGNQLYVFGGGERGAQPVEDVKLhvFDANTLTWSQPETHGSPPSPRHGH--VMVAAGTKLFIHGGLAGDK 147
Cdd:PLN02772   29 TSVTIGDKTYVIGGNHEGNTLSIGVQI--LDKITNNWVSPIVLGTGPKPCKGYsaVVLNKDRILVIKKGSAPDD 100
Kelch_4 pfam13418
Galactose oxidase, central domain;
124-167 7.04e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.82  E-value: 7.04e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1720398524 124 PRHGHVMVA-AGTKLFIHGGLAGD-KFFDDLHCIDIGDMSWQKLGP 167
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGS 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 124-167 8.75e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.44  E-value: 8.75e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720398524 124 PRHGHVMVAAGTKLFIHGGLAGDKFFDDLHCIDIGDMSWQKLGP 167
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_3 pfam13415
Galactose oxidase, central domain;
32-79 1.41e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 36.11  E-value: 1.41e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720398524  32 HSIWVFGGADQSGNR--NCLQVMSPDR-TWSTpevTGSPPSPRTFHTSSAA 79
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrlNDLYVYDLDTnTWTQ---IGDLPPPRSGHSATYI 49
Kelch smart00612
Kelch domain;
188-233 2.30e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.23  E-value: 2.30e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1720398524  188 YMFGGMTATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHSMCVI 233
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
Kelch_4 pfam13418
Galactose oxidase, central domain;
70-114 3.84e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.90  E-value: 3.84e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1720398524  70 PRTFHTSSAAIGNQLYVFGGGERGAQPVEDvkLHVFDANTLTWSQ 114
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSD--LWVFDLSTNEWTR 43
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
4-100 5.21e-03

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 37.83  E-value: 5.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524   4 GTHQWDTATREGLLP--RYEHASFLPScspHSIWVFGGadQSGNRNCLQVMSPDR-TWSTpevTGSPPSPRTFHTSsAAI 80
Cdd:COG3055   180 GSGFSNTWTTLAPLPtaRAGHAAAVLG---GKILVFGG--ESGFSDEVEAYDPATnTWTA---LGELPTPRHGHAA-VLT 250

                          90       100
                  ....*....|....*....|
gi 1720398524  81 GNQLYVFGGGERGAQPVEDV 100
Cdd:COG3055   251 DGKVYVIGGETKPGVRTPLV 270
PRK14131 PRK14131
N-acetylneuraminate epimerase;
77-174 6.42e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 37.69  E-value: 6.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  77 SAAIGNQLYVfGGGERGaqpvedVKLHVFDANTLTWSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLaGDK-------FF 149
Cdd:PRK14131   34 GAIDNNTVYV-GLGSAG------TSWYKLDLNAPSKGWTKIAAFPGGPREQAVAAFIDGKLYVFGGI-GKTnsegspqVF 105

                          90       100
                  ....*....|....*....|....*
gi 1720398524 150 DDLHCIDIGDMSWQKLgPTGAvPVG 174
Cdd:PRK14131  106 DDVYKYDPKTNSWQKL-DTRS-PVG 128
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 70-114 8.45e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 33.74  E-value: 8.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1720398524  70 PRTFHtSSAAIGNQLYVFGGGeRGAQPVEDVklHVFDANTLTWSQ 114
Cdd:pfam01344   1 RRSGA-GVVVVGGKIYVIGGF-DGNQSLNSV--EVYDPETNTWSK 41
PHA03098 PHA03098
kelch-like protein; Provisional
 76-233 8.69e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 37.44  E-value: 8.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524  76 SSAAIGNQLYVFGGgERGAQPVEDVKLHVFDANTltWSQpethgSPP--SPRHGHVMVAAGTKLFIHGGLA-GDKFFDDL 152
Cdd:PHA03098  337 GVTVFNNRIYVIGG-IYNSISLNTVESWKPGESK--WRE-----EPPliFPRYNPCVVNVNNLIYVIGGISkNDELLKTV 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398524 153 HCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMT---ATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHS 229
Cdd:PHA03098  409 ECFSLNTNKWSKGSPL---PISHYGGCAIYHDGKIYVIGGISyidNIKVYNIVESYNPVTNKWTEL---SSLNFPRINAS 482


                  ....
gi 1720398524 230 MCVI 233
Cdd:PHA03098  483 LCIF 486
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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