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Conserved domains on  [gi|1720398529|ref|XP_030105885|]
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rab9 effector protein with kelch motifs isoform X8 [Mus musculus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 1015026)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
7-246 1.31e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.12  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529   7 TWSTpevTGSPPSPRTfHTSSAAIGNQLYVFGG--GERGAQPVEdvklhVFDANTLTWSQpeTHGSPPSPRHGHVMVAAG 84
Cdd:COG3055     2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGlsGGSASNSFE-----VYDPATNTWSE--LAPLPGPPRHHAAAVAQD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529  85 TKLFIHGGLAGDK----FFDDLHCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQ 160
Cdd:COG3055    71 GKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529 161 HWTVLqfdTSLPAGRLDHSMCVIPwpvmstsenkdSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLL----CFVFG 236
Cdd:COG3055   148 TWTQL---APLPTPRDHLAAAVLP-----------DGKILVIGGRNGSGFSNTWTTLAPLPTARAGHAAAVlggkILVFG 213

                         250
                  ....*....|...
gi 1720398529 237 GM---NTEGEVYD 246
Cdd:COG3055   214 GEsgfSDEVEAYD 226
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
7-246 1.31e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.12  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529   7 TWSTpevTGSPPSPRTfHTSSAAIGNQLYVFGG--GERGAQPVEdvklhVFDANTLTWSQpeTHGSPPSPRHGHVMVAAG 84
Cdd:COG3055     2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGlsGGSASNSFE-----VYDPATNTWSE--LAPLPGPPRHHAAAVAQD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529  85 TKLFIHGGLAGDK----FFDDLHCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQ 160
Cdd:COG3055    71 GKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529 161 HWTVLqfdTSLPAGRLDHSMCVIPwpvmstsenkdSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLL----CFVFG 236
Cdd:COG3055   148 TWTQL---APLPTPRDHLAAAVLP-----------DGKILVIGGRNGSGFSNTWTTLAPLPTARAGHAAAVlggkILVFG 213

                         250
                  ....*....|...
gi 1720398529 237 GM---NTEGEVYD 246
Cdd:COG3055   214 GEsgfSDEVEAYD 226
PLN02193 PLN02193
nitrile-specifier protein
 8-176 4.94e-16

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 76.92  E-value: 4.94e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529   8 WSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVeDVKLHVFDANTLTWS-QPETHGSPPSPRHGHVMVAAGTK 86
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529  87 LFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWtvlq 166
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                         170
                  ....*....|
gi 1720398529 167 FDTSLPAGRL 176
Cdd:PLN02193  307 FHCSTPGDSF 316
Kelch_3 pfam13415
Galactose oxidase, central domain;
31-83 2.39e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.43  E-value: 2.39e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720398529  31 GNQLYVFGGGERGAQPVEDvKLHVFDANTLTWSQPethGSPPSPRHGHVMVAA 83
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
Kelch smart00612
Kelch domain;
138-183 1.76e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.61  E-value: 1.76e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1720398529  138 YMFGGMTATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHSMCVI 183
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
7-246 1.31e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 77.12  E-value: 1.31e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529   7 TWSTpevTGSPPSPRTfHTSSAAIGNQLYVFGG--GERGAQPVEdvklhVFDANTLTWSQpeTHGSPPSPRHGHVMVAAG 84
Cdd:COG3055     2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGlsGGSASNSFE-----VYDPATNTWSE--LAPLPGPPRHHAAAVAQD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529  85 TKLFIHGGLAGDK----FFDDLHCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQ 160
Cdd:COG3055    71 GKLYVFGGFTGANpsstPLNDVYVYDPATNTWTKLAPM---PTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATG 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529 161 HWTVLqfdTSLPAGRLDHSMCVIPwpvmstsenkdSDSVILTLQDEKGDAAEKAETQSGGPHEESPTTVLL----CFVFG 236
Cdd:COG3055   148 TWTQL---APLPTPRDHLAAAVLP-----------DGKILVIGGRNGSGFSNTWTTLAPLPTARAGHAAAVlggkILVFG 213

                         250
                  ....*....|...
gi 1720398529 237 GM---NTEGEVYD 246
Cdd:COG3055   214 GEsgfSDEVEAYD 226
PLN02193 PLN02193
nitrile-specifier protein
 8-176 4.94e-16

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 76.92  E-value: 4.94e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529   8 WSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVeDVKLHVFDANTLTWS-QPETHGSPPSPRHGHVMVAAGTK 86
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529  87 LFIHGGLAGDKFFDDLHCIDIGDMSWQKLGPTGAVPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHTEKQHWtvlq 166
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW---- 306

                         170
                  ....*....|
gi 1720398529 167 FDTSLPAGRL 176
Cdd:PLN02193  307 FHCSTPGDSF 316
PLN02153 PLN02153
epithiospecifier protein
 15-157 2.22e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 71.56  E-value: 2.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529  15 GSPPSPRTFHtSSAAIGNQLYVFGGgERGAQPVEDVKLHVFDANTLTWSQPETHGSPPS-PRHGHVMVAAGTKLFIHGGL 93
Cdd:PLN02153   17 GKGPGPRCSH-GIAVVGDKLYSFGG-ELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGR 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720398529  94 AGDKFFDDLHCIDIGDMSWQ---KLGPTGAvPVGCAAHAAVAVGHHVYMFGGMTATGALNMMYKYHT 157
Cdd:PLN02153   95 DEKREFSDFYSYDTVKNEWTfltKLDEEGG-PEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRT 160
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
3-148 3.25e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 59.01  E-value: 3.25e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529   3 PEDRTWSTpevTGSPPSPRTFHTSSAAIGNQLYVFGGGErgaqpvedvklhvFDANTLTWSQPETHgspPSPRHGHVMVA 82
Cdd:COG3055   144 PATGTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN-------------GSGFSNTWTTLAPL---PTARAGHAAAV 204

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720398529  83 AGTKLFIHGGLAGdkFFDDLHCIDIGDMSWQKLGPtgaVPVGCAAHAAVAVGHHVYMFGGMTATGA 148
Cdd:COG3055   205 LGGKILVFGGESG--FSDEVEAYDPATNTWTALGE---LPTPRHGHAAVLTDGKVYVIGGETKPGV 265
PLN02193 PLN02193
nitrile-specifier protein
 4-112 8.31e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 52.27  E-value: 8.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529   4 EDRTWSTPEVTGSPPSPRTFHTSSAAIGNQLYVFGGGERGAQPvedVKLHVFDANTLTWS--QPETHGspPSPRHGHVMV 81
Cdd:PLN02193  201 ETRTWSISPATGDVPHLSCLGVRMVSIGSTLYVFGGRDASRQY---NGFYSFDTTTNEWKllTPVEEG--PTPRSFHSMA 275

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1720398529  82 AAGTKLFIHGGLAGDKFFDDLHCIDIGDMSW 112
Cdd:PLN02193  276 ADEENVYVFGGVSATARLKTLDSYNIVDKKW 306
Kelch_3 pfam13415
Galactose oxidase, central domain;
31-83 2.39e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.43  E-value: 2.39e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1720398529  31 GNQLYVFGGGERGAQPVEDvKLHVFDANTLTWSQPethGSPPSPRHGHVMVAA 83
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLN-DLYVYDLDTNTWTQI---GDLPPPRSGHSATYI 49
PRK14131 PRK14131
N-acetylneuraminate epimerase;
27-106 1.16e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 45.78  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529  27 SAAIGNQLYVFGGGERGA-----QPVEDVklHVFDANTLTWSQPETHgsppSPRH--GHVMVAA-GTKLFIHGGLAG--- 95
Cdd:PRK14131   80 AAFIDGKLYVFGGIGKTNsegspQVFDDV--YKYDPKTNSWQKLDTR----SPVGlaGHVAVSLhNGKAYITGGVNKnif 153

                          90
                  ....*....|.
gi 1720398529  96 DKFFDDLHCID 106
Cdd:PRK14131  154 DGYFEDLAAAG 164
Kelch_6 pfam13964
Kelch motif;
20-75 1.65e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.17  E-value: 1.65e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1720398529  20 PRTFHtSSAAIGNQLYVFGGGERGAQPVEdvKLHVFDANTLTWsqpETHGSPPSPR 75
Cdd:pfam13964   1 PRTFH-SVVSVGGYIYVFGGYTNASPALN--KLEVYNPLTKSW---EELPPLPTPR 50
PLN02153 PLN02153
epithiospecifier protein
 6-119 2.15e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 41.90  E-value: 2.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529   6 RTWSTPEVTGSPPSPRTFHTSSAAIGNQLYVFGGGERgAQPVEDvkLHVFDANTLTW---SQPETHGSPPSpRHGHVMVA 82
Cdd:PLN02153   60 HTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGGRDE-KREFSD--FYSYDTVKNEWtflTKLDEEGGPEA-RTFHSMAS 135

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1720398529  83 AGTKLFIHGGLAGD------KFFDDLHCIDIGDMSWQKLGPTG 119
Cdd:PLN02153  136 DENHVYVFGGVSKGglmktpERFRTIEAYNIADGKWVQLPDPG 178
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 72-103 2.51e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.54  E-value: 2.51e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1720398529  72 PSPRHGHVMVAAGTKLFIHGG--LAGDKFFDDLH 103
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGytGGEGQPSDDVY 34
Kelch_4 pfam13418
Galactose oxidase, central domain;
74-117 4.42e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.21  E-value: 4.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1720398529  74 PRHGHVMVA-AGTKLFIHGGLAGD-KFFDDLHCIDIGDMSWQKLGP 117
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLGS 46
PLN02772 PLN02772
guanylate kinase
 26-97 5.77e-04

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 40.59  E-value: 5.77e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720398529  26 SSAAIGNQLYVFGGGERGAQPVEDVKLhvFDANTLTWSQPETHGSPPSPRHGH--VMVAAGTKLFIHGGLAGDK 97
Cdd:PLN02772   29 TSVTIGDKTYVIGGNHEGNTLSIGVQI--LDKITNNWVSPIVLGTGPKPCKGYsaVVLNKDRILVIKKGSAPDD 100
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 74-117 6.38e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 6.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720398529  74 PRHGHVMVAAGTKLFIHGGLAGDKFFDDLHCIDIGDMSWQKLGP 117
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
PLN02153 PLN02153
epithiospecifier protein
 3-103 1.36e-03

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 39.58  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529   3 PEDRTWSTPEVTGSPPSPRTFHtSSAAIGNQLYVFGG-------GERGAQPVEDvKLHVFDANTLTWSQPETHGSPPSPR 75
Cdd:PLN02153  224 PASGKWTEVETTGAKPSARSVF-AHAVVGKYIIIFGGevwpdlkGHLGPGTLSN-EGYALDTETLVWEKLGECGEPAMPR 301

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1720398529  76 HGHVMVAA---GTK-LFIHGG-LAGDKFFDDLH 103
Cdd:PLN02153  302 GWTAYTTAtvyGKNgLLMHGGkLPTNERTDDLY 334
Kelch smart00612
Kelch domain;
138-183 1.76e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 35.61  E-value: 1.76e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1720398529  138 YMFGGMTATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHSMCVI 183
Cdd:smart00612   3 YVVGGFDGGQRLKSVEVYDPETNKWTPL---PSMPTPRSGHGVAVI 45
Kelch_4 pfam13418
Galactose oxidase, central domain;
20-64 2.49e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 2.49e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1720398529  20 PRTFHTSSAAIGNQLYVFGGGERGAQPVEDvkLHVFDANTLTWSQ 64
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGGEGEDGTLLSD--LWVFDLSTNEWTR 43
PRK14131 PRK14131
N-acetylneuraminate epimerase;
27-124 5.59e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 37.69  E-value: 5.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529  27 SAAIGNQLYVfGGGERGaqpvedVKLHVFDANTLTWSQPETHGSPPSPRHGHVMVAAGTKLFIHGGLaGDK-------FF 99
Cdd:PRK14131   34 GAIDNNTVYV-GLGSAG------TSWYKLDLNAPSKGWTKIAAFPGGPREQAVAAFIDGKLYVFGGI-GKTnsegspqVF 105

                          90       100
                  ....*....|....*....|....*
gi 1720398529 100 DDLHCIDIGDMSWQKLgPTGAvPVG 124
Cdd:PRK14131  106 DDVYKYDPKTNSWQKL-DTRS-PVG 128
PHA03098 PHA03098
kelch-like protein; Provisional
 26-183 6.01e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 37.44  E-value: 6.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529  26 SSAAIGNQLYVFGGgERGAQPVEDVKLHVFDANTltWSQpethgSPP--SPRHGHVMVAAGTKLFIHGGLA-GDKFFDDL 102
Cdd:PHA03098  337 GVTVFNNRIYVIGG-IYNSISLNTVESWKPGESK--WRE-----EPPliFPRYNPCVVNVNNLIYVIGGISkNDELLKTV 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398529 103 HCIDIGDMSWQKLGPTgavPVGCAAHAAVAVGHHVYMFGGMT---ATGALNMMYKYHTEKQHWTVLqfdTSLPAGRLDHS 179
Cdd:PHA03098  409 ECFSLNTNKWSKGSPL---PISHYGGCAIYHDGKIYVIGGISyidNIKVYNIVESYNPVTNKWTEL---SSLNFPRINAS 482


                  ....
gi 1720398529 180 MCVI 183
Cdd:PHA03098  483 LCIF 486
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 20-64 6.06e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 33.74  E-value: 6.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1720398529  20 PRTFHtSSAAIGNQLYVFGGGeRGAQPVEDVklHVFDANTLTWSQ 64
Cdd:pfam01344   1 RRSGA-GVVVVGGKIYVIGGF-DGNQSLNSV--EVYDPETNTWSK 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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