|
Name |
Accession |
Description |
Interval |
E-value |
| DENN |
smart00799 |
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
65-243 |
1.34e-62 |
|
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
:
Pssm-ID: 214823 Cd Length: 183 Bit Score: 210.51 E-value: 1.34e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 65 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 139
Cdd:smart00799 3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 140 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 219
Cdd:smart00799 80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159
|
170 180
....*....|....*....|....
gi 1720398542 220 HLSLMEKVRNMALDDVVILNVDTN 243
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
|
|
| dDENN |
smart00801 |
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
275-341 |
1.86e-16 |
|
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
:
Pssm-ID: 129037 Cd Length: 69 Bit Score: 74.63 E-value: 1.86e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 275 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 341
Cdd:smart00801 1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
662-988 |
1.64e-14 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.83 E-value: 1.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 662 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 741
Cdd:PHA03247 2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 742 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 816
Cdd:PHA03247 2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 817 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 891
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 892 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 962
Cdd:PHA03247 2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929
|
330 340
....*....|....*....|....*.
gi 1720398542 963 GESPLLPPRPPQSLQPTPQPSVPTQA 988
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
|
| uDENN |
smart00800 |
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ... |
14-61 |
2.78e-13 |
|
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
:
Pssm-ID: 214824 Cd Length: 89 Bit Score: 66.20 E-value: 2.78e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1720398542 14 QEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 61
Cdd:smart00800 40 FPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DENN |
smart00799 |
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
65-243 |
1.34e-62 |
|
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214823 Cd Length: 183 Bit Score: 210.51 E-value: 1.34e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 65 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 139
Cdd:smart00799 3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 140 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 219
Cdd:smart00799 80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159
|
170 180
....*....|....*....|....
gi 1720398542 220 HLSLMEKVRNMALDDVVILNVDTN 243
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
|
|
| DENN |
pfam02141 |
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
66-243 |
9.61e-44 |
|
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.
Pssm-ID: 460461 Cd Length: 186 Bit Score: 156.96 E-value: 9.61e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 66 CFCILSYLPWFEVFYKLLNILAdytTKRQESQWNELLET-----LHRLPIPDPGVSVHLSVHS-----YFTVPDSRELPS 135
Cdd:pfam02141 5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 136 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 215
Cdd:pfam02141 82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159
|
170 180
....*....|....*....|....*...
gi 1720398542 216 LIGIHLSLMEKVRNmALDDVVILNVDTN 243
Cdd:pfam02141 160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
|
|
| dDENN |
smart00801 |
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
275-341 |
1.86e-16 |
|
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 129037 Cd Length: 69 Bit Score: 74.63 E-value: 1.86e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 275 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 341
Cdd:smart00801 1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
662-988 |
1.64e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.83 E-value: 1.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 662 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 741
Cdd:PHA03247 2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 742 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 816
Cdd:PHA03247 2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 817 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 891
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 892 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 962
Cdd:PHA03247 2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929
|
330 340
....*....|....*....|....*.
gi 1720398542 963 GESPLLPPRPPQSLQPTPQPSVPTQA 988
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
|
| uDENN |
smart00800 |
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ... |
14-61 |
2.78e-13 |
|
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214824 Cd Length: 89 Bit Score: 66.20 E-value: 2.78e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1720398542 14 QEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 61
Cdd:smart00800 40 FPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
663-986 |
5.10e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.00 E-value: 5.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 663 SKPSITSPEK------PSALLGTSPALPLRPQNQEGILSPSikeETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAK 736
Cdd:pfam03154 144 TSPSIPSPQDnesdsdSSAQQQILQTQPPVLQAQSGAASPP---SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQ 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 737 LQAAGGPLGDFSSEPlQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPS------PAPGAAGTGsdallalldplnta 810
Cdd:pfam03154 221 TQSTAAPHTLIQQTP-TLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmpPMPHSLQTG-------------- 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 811 wsgstiPSHPATPSAATPF-IPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAY----- 884
Cdd:pfam03154 286 ------PSHMQHPVPPQPFpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHikppp 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 885 ---APSILLSSSGFYAPHRSQPnlSALSMP-------------NLFGQIPMGAHTSPL------QPLGPPAVAPSRIRTL 942
Cdd:pfam03154 360 ttpIPQLPNPQSHKHPPHLSGP--SPFQMNsnlppppalkplsSLSTHHPPSAHPPPLqlmpqsQQLPPPPAQPPVLTQS 437
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1720398542 943 PLARSSARAAEAKQGLALRPGESP-----LLPPRPPQSLQP-TPQPSVPT 986
Cdd:pfam03154 438 QSLPPPAASHPPTSGLHQVPSQSPfpqhpFVPGGPPPITPPsGPPTSTSS 487
|
|
| dDENN |
pfam03455 |
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
307-358 |
9.77e-07 |
|
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.
Pssm-ID: 460925 Cd Length: 48 Bit Score: 46.42 E-value: 9.77e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1720398542 307 FSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 358
Cdd:pfam03455 1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
|
|
| uDENN |
pfam03456 |
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
17-59 |
1.70e-06 |
|
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.
Pssm-ID: 460926 Cd Length: 59 Bit Score: 46.06 E-value: 1.70e-06
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1720398542 17 LQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 59
Cdd:pfam03456 18 PDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
728-938 |
2.93e-05 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 47.58 E-value: 2.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 728 PPPTARPAKLQAAGGPLGDFSSEPLQMD---RERQAALSPALLSGLLPRAVPQGPTELLQPPSPApGAAGTGSDALLALL 804
Cdd:COG5651 165 TPFTQPPPTITNPGGLLGAQNAGSGNTSsnpGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNT-GFAGTGAAAGAAAA 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 805 DPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFGTPPASL 880
Cdd:COG5651 244 AAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAaatgLGLGAGGAAGAAGATG 323
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1720398542 881 GPAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSR 938
Cdd:COG5651 324 AGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGG 381
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DENN |
smart00799 |
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ... |
65-243 |
1.34e-62 |
|
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214823 Cd Length: 183 Bit Score: 210.51 E-value: 1.34e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 65 SCFCILSYLPWFEVFYKLLNILADYTTKRQESQwNELLETLHRLPIPDPG-----VSVHLSVHSYFTVPDSRELPSIPen 139
Cdd:smart00799 3 KCICILSRLPFFELFRKILNELYRLLPSSSNLP-LELLISLLLYPVPPPGgslvlVSLGPGDLIELQRPLDSSLPLID-- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 140 RNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPYLIGI 219
Cdd:smart00799 80 FSLHELFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFIIGV 159
|
170 180
....*....|....*....|....
gi 1720398542 220 HLSLMEKVRNMALDDVVILNVDTN 243
Cdd:smart00799 160 HSSYFEEVKELPDEDVVVVDLDTG 183
|
|
| DENN |
pfam02141 |
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ... |
66-243 |
9.61e-44 |
|
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.
Pssm-ID: 460461 Cd Length: 186 Bit Score: 156.96 E-value: 9.61e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 66 CFCILSYLPWFEVFYKLLNILAdytTKRQESQWNELLET-----LHRLPIPDPGVSVHLSVHS-----YFTVPDSRELPS 135
Cdd:pfam02141 5 AYCIISRLPFFNLFKKFLDELY---RRRTISPLPNPIERfianlLYEVPFPPPGRTQKLKPLGgtepiLLQRPEDSELPL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 136 ipENRNLTEYFVAVDVNNMLHLYASMLYERRILIICSKLSTLTACIHGSAAMLYPMYWQHVYIPVLPPHLLDYCCAPMPY 215
Cdd:pfam02141 82 --EGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPTPF 159
|
170 180
....*....|....*....|....*...
gi 1720398542 216 LIGIHLSLMEKVRNmALDDVVILNVDTN 243
Cdd:pfam02141 160 IIGVHSRYFDLLED-PLDDVVLVDLDTG 186
|
|
| dDENN |
smart00801 |
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ... |
275-341 |
1.86e-16 |
|
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 129037 Cd Length: 69 Bit Score: 74.63 E-value: 1.86e-16
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 275 GDGVARAFLKAQAAFFGSYRNALK---IEPEEPITFSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGR 341
Cdd:smart00801 1 NDEIREAFLRFFVNLFGGYRNFLRelrKEPGPVITFDKESFLKS-RPSSERPFLSKFLETQMFSQFIEER 69
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
662-988 |
1.64e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 78.83 E-value: 1.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 662 PSKPSITSPEKPSAllGTSPAlPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAG 741
Cdd:PHA03247 2616 PLPPDTHAPDPPPP--SPSPA-ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTV 2692
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 742 GPLGDFSSEPLQ--MDRERQAALSPALLSGLLPRAVPQG---PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 816
Cdd:PHA03247 2693 GSLTSLADPPPPppTPEPAPHALVSATPLPPGPAAARQAspaLPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPP 2772
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 817 PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPfVPSVPVVPPSMPLSSTPARPFGTPPASL--GPAYAPSIL---LS 891
Cdd:PHA03247 2773 AAPAAGPPRRLTRPAVASLSESRESLPSPWDPADP-PAAVLAPAAALPPAASPAGPLPPPTSAQptAPPPPPGPPppsLP 2851
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 892 SSGFYAP----HRSQPNLSALSMPNLFGQIPMG-----AHTSPLQPLGPPAVAPSRIRTLPLARSSARAAEAKQglALRP 962
Cdd:PHA03247 2852 LGGSVAPggdvRRRPPSRSPAAKPAAPARPPVRrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPP--PPQP 2929
|
330 340
....*....|....*....|....*.
gi 1720398542 963 GESPLLPPRPPQSLQPTPQPSVPTQA 988
Cdd:PHA03247 2930 QPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
|
| uDENN |
smart00800 |
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ... |
14-61 |
2.78e-13 |
|
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Pssm-ID: 214824 Cd Length: 89 Bit Score: 66.20 E-value: 2.78e-13
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 1720398542 14 QEVLQTLTKFCFPFYVD--SLTVSQVGQNFTFVLTDIDSKQRFGFCRLSS 61
Cdd:smart00800 40 FPLPDSIPLFCFPEGLDfvTQTSSKDPQFFSFVLTDIDGSRRYGFCLRFY 89
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
662-987 |
5.12e-13 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 73.82 E-value: 5.12e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 662 PSKPSITSPE-KPSAllgtsPALPLRPQnqegilspsikeeTPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAA 740
Cdd:PHA03247 2577 PSEPAVTSRArRPDA-----PPQSARPR-------------APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEP 2638
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 741 GGPLGDFSSEPLQMD------RERQAALSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAW-SG 813
Cdd:PHA03247 2639 DPHPPPTVPPPERPRddpapgRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALvSA 2718
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 814 STIPSHPATPSAATPFIPQLSFPPTVTPTPfvQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYAPSILLSSS 893
Cdd:PHA03247 2719 TPLPPGPAAARQASPALPAAPAPPAVPAGP--ATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRE 2796
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 894 GFYAPHRSQPNLSALSMPNlfgqIPMGAHTSPLQPLGPPavaPSRIRTLPLARSSARAAEAKQGLALRPG---------- 963
Cdd:PHA03247 2797 SLPSPWDPADPPAAVLAPA----AALPPAASPAGPLPPP---TSAQPTAPPPPPGPPPPSLPLGGSVAPGgdvrrrppsr 2869
|
330 340
....*....|....*....|....*..
gi 1720398542 964 ---ESPLLPPRPPQSLQPTPQPSVPTQ 987
Cdd:PHA03247 2870 spaAKPAAPARPPVRRLARPAVSRSTE 2896
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
540-989 |
4.66e-11 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 67.66 E-value: 4.66e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 540 PQPYRTlkesdSAEGDETESPeqlvREPWGPTPAPPDRAASidlleDVFSSLDVEAPLQPLGQAKSLEDLRAPKDLREQP 619
Cdd:PHA03247 2593 PQSARP-----RAPVDDRGDP----RGPAPPSPLPPDTHAP-----DPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAP 2658
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 620 GSFDYQRlDLCRSERGLSMAAALKLAHPYTKLWSLGQ-DDMAIPSKPSITSPEKPSAllgTSPALPLRPQNQEGILSPSI 698
Cdd:PHA03247 2659 GRVSRPR-RARRLGRAAQASSPPQRPRRRAARPTVGSlTSLADPPPPPPTPEPAPHA---LVSATPLPPGPAAARQASPA 2734
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 699 KEETPIPTPGSITIPRPQGRKTPElgivPPPPTARPAKLQAAGGPLGdfsSEPLQMDRERQAALSPALLSGLLPRAvPQG 778
Cdd:PHA03247 2735 LPAAPAPPAVPAGPATPGGPARPA----RPPTTAGPPAPAPPAAPAA---GPPRRLTRPAVASLSESRESLPSPWD-PAD 2806
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 779 PTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTIPSHPATP--SAATPFIPQLSFPPTVTPTPFVQTPLNPfvpsv 856
Cdd:PHA03247 2807 PPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPlgGSVAPGGDVRRRPPSRSPAAKPAAPARP----- 2881
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 857 PVVPPSMPLSSTPARPFGTPPASLGPAYAPSIllsssgfYAPHRSQPNLSALSMPNLFGQIPmGAHTSPLQPLGPPAVAP 936
Cdd:PHA03247 2882 PVRRLARPAVSRSTESFALPPDQPERPPQPQA-------PPPPQPQPQPPPPPQPQPPPPPP-PRPQPPLAPTTDPAGAG 2953
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1720398542 937 SRIRTLPlarssaraaeAKQGLALRPGESPLLPPRPPQSLQPTPQPSVPTQAR 989
Cdd:PHA03247 2954 EPSGAVP----------QPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPL 2996
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
663-986 |
5.10e-07 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 54.00 E-value: 5.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 663 SKPSITSPEK------PSALLGTSPALPLRPQNQEGILSPSikeETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAK 736
Cdd:pfam03154 144 TSPSIPSPQDnesdsdSSAQQQILQTQPPVLQAQSGAASPP---SPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQ 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 737 LQAAGGPLGDFSSEPlQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPS------PAPGAAGTGsdallalldplnta 810
Cdd:pfam03154 221 TQSTAAPHTLIQQTP-TLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSlhgqmpPMPHSLQTG-------------- 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 811 wsgstiPSHPATPSAATPF-IPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAY----- 884
Cdd:pfam03154 286 ------PSHMQHPVPPQPFpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHikppp 359
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 885 ---APSILLSSSGFYAPHRSQPnlSALSMP-------------NLFGQIPMGAHTSPL------QPLGPPAVAPSRIRTL 942
Cdd:pfam03154 360 ttpIPQLPNPQSHKHPPHLSGP--SPFQMNsnlppppalkplsSLSTHHPPSAHPPPLqlmpqsQQLPPPPAQPPVLTQS 437
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1720398542 943 PLARSSARAAEAKQGLALRPGESP-----LLPPRPPQSLQP-TPQPSVPT 986
Cdd:pfam03154 438 QSLPPPAASHPPTSGLHQVPSQSPfpqhpFVPGGPPPITPPsGPPTSTSS 487
|
|
| dDENN |
pfam03455 |
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ... |
307-358 |
9.77e-07 |
|
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.
Pssm-ID: 460925 Cd Length: 48 Bit Score: 46.42 E-value: 9.77e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 1720398542 307 FSEEAFVSHyRSGAMKQFLQNATQLQLFKQFIDGRLDLLNsgeGFSDVFEEE 358
Cdd:pfam03455 1 FDKEAFLKS-LPSDSRPFLSQFLETQMFNEFIEERLESSD---PSIDLFDEE 48
|
|
| uDENN |
pfam03456 |
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ... |
17-59 |
1.70e-06 |
|
uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.
Pssm-ID: 460926 Cd Length: 59 Bit Score: 46.06 E-value: 1.70e-06
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 1720398542 17 LQTLTKFCFPFYVDSLtVSQVGQNFTFVLTDIDSKQRFGFCRL 59
Cdd:pfam03456 18 PDGIPMFCFPEGLETL-SSREPTFFSFVLTDEDGSRLYGACLT 59
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
661-984 |
2.79e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 51.69 E-value: 2.79e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 661 IPSKPSITSPEKPSALLGTSPALPLRPQNQEGILS-PSIKEETPIPTPGSITIPRPQGRKTPelgiVPPPPTARPAKLQA 739
Cdd:pfam03154 231 IQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPlPQPSLHGQMPPMPHSLQTGPSHMQHP----VPPQPFPLTPQSSQ 306
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 740 AGGPLGDFSSEPLQM-DRERQAALSPALLSGLLPRAVPQGPTEL----LQPP--SPAPGAAGTGSDallalldplntaws 812
Cdd:pfam03154 307 SQVPPGPSPAAPGQSqQRIHTPPSQSQLQSQQPPREQPLPPAPLsmphIKPPptTPIPQLPNPQSH-------------- 372
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 813 gstipSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFG-------TPPASLG 881
Cdd:pfam03154 373 -----KHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPqsqqLPPPPAQPPVltqsqslPPPAASH 447
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 882 PAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPlgPPAVAPSRIRTLPLARSSARAAEAKQGLALR 961
Cdd:pfam03154 448 PPTSGLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQP--PSSASVSSSGPVPAAVSCPLPPVQIKEEALD 525
|
330 340
....*....|....*....|...
gi 1720398542 962 PGESPLLPPRPPQSlqPTPQPSV 984
Cdd:pfam03154 526 EAEEPESPPPPPRS--PSPEPTV 546
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
653-996 |
4.27e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 51.09 E-value: 4.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 653 SLGQDDMAIPSKPSITSPekpSALLGTSPALPLRPQNQEGI--LSPSIKEETPIPTPGSITIPRPqgrKTPELGIVPPPP 730
Cdd:PHA03247 2500 GGGPPDPDAPPAPSRLAP---AILPDEPVGEPVHPRMLTWIrgLEELASDDAGDPPPPLPPAAPP---AAPDRSVPPPRP 2573
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 731 TARPaklqaaggplgdfsSEPLQMDRERQAALSPALLSGLLPRAVPQGP------------TELLQPPSPAPGAAGT--- 795
Cdd:PHA03247 2574 APRP--------------SEPAVTSRARRPDAPPQSARPRAPVDDRGDPrgpappsplppdTHAPDPPPPSPSPAANepd 2639
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 796 -GSDALLALLDPLNTAWSGSTI--------PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLS 866
Cdd:PHA03247 2640 pHPPPTVPPPERPRDDPAPGRVsrprrarrLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSAT 2719
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 867 STPARPFGTPPASLGPAYAPSILLSSSGFYAP--HRSQPNLSALSMPNLfGQIPMGAHTSPLQPLGPPAVAPSRIRTLPL 944
Cdd:PHA03247 2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPggPARPARPPTTAGPPA-PAPPAAPAAGPPRRLTRPAVASLSESRESL 2798
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 1720398542 945 ARSSARAAEAKQGLALRPGESPLLPPRPPQSLQPTPQPSVPTQARDPFEDLL 996
Cdd:PHA03247 2799 PSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSL 2850
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
683-929 |
7.52e-06 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 49.87 E-value: 7.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 683 LPLRPQNQEGILSPsikeetpiPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQAAGgplgdfSSEPLQMDRERQAAL 762
Cdd:PRK12323 361 LAFRPGQSGGGAGP--------ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPA------AAAAARAVAAAPARR 426
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 763 SPAL--LSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVT 840
Cdd:PRK12323 427 SPAPeaLAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEF 506
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 841 PTPFVQtPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYAPSILLSSSGFYAPHRsqPNLSALSMPNLF-GQIPM 919
Cdd:PRK12323 507 ASPAPA-QPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRP--PRASASGLPDMFdGDWPA 583
|
250
....*....|
gi 1720398542 920 GAHTSPLQPL 929
Cdd:PRK12323 584 LAARLPVRGL 593
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
659-1003 |
2.29e-05 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 48.63 E-value: 2.29e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 659 MAIPSKPSITSPEKPSALLGTSPALPLRPQNQEGILSPSIKEETPIPTPGSITIPRPQGRKTPELGIVPPPPTARPAKLQ 738
Cdd:PHA03307 60 AACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLR 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 739 AAG--GPLGDFSSEPLQMDRERQAA-----LSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAW 811
Cdd:PHA03307 140 PVGspGPPPAASPPAAGASPAAVASdaassRQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASS 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 812 SGSTIPSHPATPSAATPFIPQLSFPP-------TVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASlGPAY 884
Cdd:PHA03307 220 PAPAPGRSAADDAGASSSDSSSSESSgcgwgpeNECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRER-SPSP 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 885 APSillSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSRIRTLPlarssaraaeakqglalrPGE 964
Cdd:PHA03307 299 SPS---SPGSGPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPS------------------RPP 357
|
330 340 350
....*....|....*....|....*....|....*....
gi 1720398542 965 SPLLPPRPPQSlqPTPQPSVPTQARDPFEDLLRKTKQDV 1003
Cdd:PHA03307 358 PPADPSSPRKR--PRPSRAPSSPAASAGRPTRRRARAAV 394
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
728-938 |
2.93e-05 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 47.58 E-value: 2.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 728 PPPTARPAKLQAAGGPLGDFSSEPLQMD---RERQAALSPALLSGLLPRAVPQGPTELLQPPSPApGAAGTGSDALLALL 804
Cdd:COG5651 165 TPFTQPPPTITNPGGLLGAQNAGSGNTSsnpGFANLGLTGLNQVGIGGLNSGSGPIGLNSGPGNT-GFAGTGAAAGAAAA 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 805 DPLNTAWSGSTIPSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMP----LSSTPARPFGTPPASL 880
Cdd:COG5651 244 AAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAaatgLGLGAGGAAGAAGATG 323
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1720398542 881 GPAYAPSILLSSSGFYAPHRSQPNLSALSMPNLFGQIPMGAHTSPLQPLGPPAVAPSR 938
Cdd:COG5651 324 AGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAGAASGG 381
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
661-931 |
1.30e-04 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 45.69 E-value: 1.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 661 IPSKPsiTSPEKPSALLGTSPAlPLRPQNQEGILSPSIKEetpiPTPGSITIPRPQGRKTPELGIVPPpptARPAKLQAA 740
Cdd:PLN03209 323 IPSQR--VPPKESDAADGPKPV-PTKPVTPEAPSPPIEEE----PPQPKAVVPRPLSPYTAYEDLKPP---TSPIPTPPS 392
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 741 GGPLGDFSSEPLQMDRERQAALSPALLSGLLPRAVPQGPTELLQPPSPApgaagtgsdallalldplnTAWSGSTIPSHP 820
Cdd:PLN03209 393 SSPASSKSVDAVAKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPY-------------------ARYEDLKPPTSP 453
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 821 aTPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAyapsillSSSGFYAPHR 900
Cdd:PLN03209 454 -SPTAPTGVSPSVSSTSSVPAVPDTAPATAATDAAAPPPANMRPLSPYAVYDDLKPPTSPSPA-------APVGKVAPSS 525
|
250 260 270
....*....|....*....|....*....|..
gi 1720398542 901 SQPNLSALSMPNLFGQIPMGAHTSPLQ-PLGP 931
Cdd:PLN03209 526 TNEVVKVGNSAPPTALADEQHHAQPKPrPLSP 557
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
431-843 |
7.84e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.77 E-value: 7.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 431 SSAEDPLPKTMPSPQAETQDPRLREDRRPITVHFGQVRPPRPHV------VRRPKsNITVEGRRTSVSSPEHlvKPLRHY 504
Cdd:PHA03247 2611 PAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDdpapgrVSRPR-RARRLGRAAQASSPPQ--RPRRRA 2687
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 505 A------VFLSEDSSDEECRREEAPSTGFTESLLFSAPFEWPQ--PYRTLKESDSAEGDETESPEQLVREPWGPTPAPPD 576
Cdd:PHA03247 2688 ArptvgsLTSLADPPPPPPTPEPAPHALVSATPLPPGPAAARQasPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPP 2767
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 577 RAASIDLLEDVFSSLDVEAPLQPLgqAKSLEDLRAPKDLREQPGSFDYQRLDLCRSERGLSMAAALKLAHPytklwslgq 656
Cdd:PHA03247 2768 APAPPAAPAAGPPRRLTRPAVASL--SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQP--------- 2836
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 657 ddmAIPSKPSITSPEKPSALLGTSPALPLRPQNQEGilSPSIKEETPiPTPGSITIPRPQGRKTPELGIVPPPPTARPAK 736
Cdd:PHA03247 2837 ---TAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSR--SPAAKPAAP-ARPPVRRLARPAVSRSTESFALPPDQPERPPQ 2910
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 737 LQAAGGPLGDFSSEPlqmdrerqaalspallsglLPRAVPQGPTellQPPSPAPGAAGTGSDALLALLDPLNTAWSGSTI 816
Cdd:PHA03247 2911 PQAPPPPQPQPQPPP-------------------PPQPQPPPPP---PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
|
410 420
....*....|....*....|....*..
gi 1720398542 817 PSHPATPSAATPfIPQLSFPPTVTPTP 843
Cdd:PHA03247 2969 PGRVAVPRFRVP-QPAPSREAPASSTP 2994
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
508-828 |
8.28e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.62 E-value: 8.28e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 508 LSEDSSDEECRREEAPSTGFT--ESLLFSAPFEWPQPYRtlkESDSAEGDETESPEQLVREPWGPTPAPPDRAASIDLLE 585
Cdd:PHA03307 10 LIEAAAEGGEFFPRPPATPGDaaDDLLSGSQGQLVSDSA---ELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 586 DVFSSLDVEAPLQPLGQAKSLEDLRAPKDLREQPGSfdyqrLDLCRSERGLSMAAALKLAHPYTklwSLGQDDMAIPSKP 665
Cdd:PHA03307 87 TPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP-----PASPPPSPAPDLSEMLRPVGSPG---PPPAASPPAAGAS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 666 SITSPEKPSALLGTSPALPLRPQNQEGILSPSikEETPIPTPGSITIPRPQGRKTPeLGIVPPPPTARPAKLQAAGGPLG 745
Cdd:PHA03307 159 PAAVASDAASSRQAALPLSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSP-ISASASSPAPAPGRSAADDAGAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 746 DFSSEPLQM----DRERQAALSPALLSGLLPRAVPQGPTELLQPPSPAPGAAGTGSDALlalldplntawSGSTIPSHPA 821
Cdd:PHA03307 236 SSDSSSSESsgcgWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRER-----------SPSPSPSSPG 304
|
....*..
gi 1720398542 822 TPSAATP 828
Cdd:PHA03307 305 SGPAPSS 311
|
|
| PHA03379 |
PHA03379 |
EBNA-3A; Provisional |
656-995 |
2.86e-03 |
|
EBNA-3A; Provisional
Pssm-ID: 223066 [Multi-domain] Cd Length: 935 Bit Score: 41.58 E-value: 2.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 656 QDDMAIPSKPSITSPEKPsallgTSPALPLRPQNQEGILSPSIKEETPiPTPGSITIPRPQGRKTPELGIVPPPPTARPA 735
Cdd:PHA03379 429 QSLETATSHGSAQVPEPP-----PVHDLEPGPLHDQHSMAPCPVAQLP-PGPLQDLEPGDQLPGVVQDGRPACAPVPAPA 502
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 736 klqaaGGPLGDFSSEPLQMDRERQAALSPALLSGllpRAVPQGPTELLQPPSPAPGAAGTGSDALLALLDPLNTAWSGST 815
Cdd:PHA03379 503 -----GPIVRPWEASLSQVPGVAFAPVMPQPMPV---EPVPVPTVALERPVCPAPPLIAMQGPGETSGIVRVRERWRPAP 574
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 816 IPSHPATPSAATPFIPQLS----------FPPTVTPTPFVQTPLNPFVPSVPVVPPSMPLSSTPARPFGTPPASLGPAYA 885
Cdd:PHA03379 575 WTPNPPRSPSQMSVRDRLArlraeaqpyqASVEVQPPQLTQVSPQQPMEYPLEPEQQMFPGSPFSQVADVMRAGGVPAMQ 654
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 886 PsillsssgfyaPHRSQPnlsaLSMPNLFGQ--IPMGAHTSPLQPLgpPAVAPSRIRtLPLARSSARAAEAKQGLALRPG 963
Cdd:PHA03379 655 P-----------QYFDLP----LQQPISQGAplAPLRASMGPVPPV--PATQPQYFD-IPLTEPINQGASAAHFLPQQPM 716
|
330 340 350
....*....|....*....|....*....|..
gi 1720398542 964 ESPLLPPRPPQSLQPTPQPSVPTQARDPFEDL 995
Cdd:PHA03379 717 EGPLVPERWMFQGATLSQSVRPGVAQSQYFDL 748
|
|
| PRK12727 |
PRK12727 |
flagellar biosynthesis protein FlhF; |
718-893 |
5.87e-03 |
|
flagellar biosynthesis protein FlhF;
Pssm-ID: 237182 [Multi-domain] Cd Length: 559 Bit Score: 40.36 E-value: 5.87e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 718 RKTPELGIVPPPPTARPAKLQAAGGPLGDFSSEPLQMDRERQAALSPALLSGL-------LPRAVPQG-PTELLQPPSPA 789
Cdd:PRK12727 60 SDTPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMIAAMalrqpvsVPRQAPAAaPVRAASIPSPA 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720398542 790 PGAAGTGSDALLALLDPLNTAWSGSTI-------PSHPATPSAATPFIPQLSFPPTVTPTPFVQTPLNPFVPSVPVVPPS 862
Cdd:PRK12727 140 AQALAHAAAVRTAPRQEHALSAVPEQLfadflttAPVPRAPVQAPVVAAPAPVPAIAAALAAHAAYAQDDDEQLDDDGFD 219
|
170 180 190
....*....|....*....|....*....|..
gi 1720398542 863 MPLSSTPA-RPFGTPPASLGPAyAPSILLSSS 893
Cdd:PRK12727 220 LDDALPQIlPPAALPPIVVAPA-APAALAAVA 250
|
|
| |
