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Conserved domains on  [gi|1720393660|ref|XP_030106475|]
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tetratricopeptide repeat protein 39C isoform X2 [Mus musculus]

Protein Classification

TTC39/IML2 family protein( domain architecture ID 706803)

TTC39/IML2 family protein is a DUF3808 domain-containing protein; similar to Saccharomyces cerevisiae inclusion body clearance protein IML2 involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Iml2-TPR_39 super family cl28743
Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to ...
 1-181 5.20e-59

Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterized proteins. Members of this family carry a tetratricopeptide repeat pfam07719 at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localizes to the cytoplasm and nucleus, and its expression is increased in response to DNA replication stress. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive. TTC39B has been linked to lipid metabolism.


The actual alignment was detected with superfamily member pfam10300:

Pssm-ID: 463047 [Multi-domain]  Cd Length: 469  Bit Score: 194.11  E-value: 5.20e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393660   1 MFFKGRIQRLECQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVC 80
Cdd:pfam10300 268 LFFEARIESLKGNLDEALELFEECIESQSEWKQVHHLCYWELMWCLVFLHNWKQAANYFLLLVKESSWSHALYTYFAAAC 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393660  81 QGATGDV-------DGAQLVLKEVQKLFKR---KNNQIEQFSVKKAERFRKQTPTRALCVLASIEVLYLWKALPNCSFPN 150
Cdd:pfam10300 348 LLMLYREeeapaakERAVELFREVPTLKQKiagKSLPLEKFAARKVQRFKARTPADAVLVSPLLELIYFWNGFSRMGKKP 427

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1720393660 151 LQRMSQACH--------------EVDDSSvvgLKHLLLGAIHKCL 181
Cdd:pfam10300 428 LLTESVLKLiekalkanptseaqEPDDKC---LKQLLKGLCLRHL 469
 
Name Accession Description Interval E-value
Iml2-TPR_39 pfam10300
Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to ...
 1-181 5.20e-59

Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterized proteins. Members of this family carry a tetratricopeptide repeat pfam07719 at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localizes to the cytoplasm and nucleus, and its expression is increased in response to DNA replication stress. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive. TTC39B has been linked to lipid metabolism.


Pssm-ID: 463047 [Multi-domain]  Cd Length: 469  Bit Score: 194.11  E-value: 5.20e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393660   1 MFFKGRIQRLECQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVC 80
Cdd:pfam10300 268 LFFEARIESLKGNLDEALELFEECIESQSEWKQVHHLCYWELMWCLVFLHNWKQAANYFLLLVKESSWSHALYTYFAAAC 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393660  81 QGATGDV-------DGAQLVLKEVQKLFKR---KNNQIEQFSVKKAERFRKQTPTRALCVLASIEVLYLWKALPNCSFPN 150
Cdd:pfam10300 348 LLMLYREeeapaakERAVELFREVPTLKQKiagKSLPLEKFAARKVQRFKARTPADAVLVSPLLELIYFWNGFSRMGKKP 427

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1720393660 151 LQRMSQACH--------------EVDDSSvvgLKHLLLGAIHKCL 181
Cdd:pfam10300 428 LLTESVLKLiekalkanptseaqEPDDKC---LKQLLKGLCLRHL 469
 
Name Accession Description Interval E-value
Iml2-TPR_39 pfam10300
Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to ...
 1-181 5.20e-59

Iml2/Tetratricopeptide repeat protein 39; This is a family of proteins conserved from fungi to humans, including fungal Inclusion body clearance protein Iml2 protein, animal tetratricopeptide repeat protein 39A/B/C (TT39A/B/C) and some uncharacterized proteins. Members of this family carry a tetratricopeptide repeat pfam07719 at their C terminus. This entry includes Iml2 and its paralogue-YKR018C from S. cerevisiae; Iml2 localizes to the cytoplasm and nucleus, and its expression is increased in response to DNA replication stress. It is found to be involved in lipid droplet-mediated inclusion body clearing after protein folding stress. In humans, TTC39A (also known as DEME6) is expressed in primary breast carcinomas but not in normal breast tissue, and has a putative eukaryotic RNP-1 RNA binding region and a candidate anchoring transmembrane domain. It is coordinately regulated with oestrogen receptor, but is not necessarily oestradiol-responsive. TTC39B has been linked to lipid metabolism.


Pssm-ID: 463047 [Multi-domain]  Cd Length: 469  Bit Score: 194.11  E-value: 5.20e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393660   1 MFFKGRIQRLECQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWSQCYYAYLTAVC 80
Cdd:pfam10300 268 LFFEARIESLKGNLDEALELFEECIESQSEWKQVHHLCYWELMWCLVFLHNWKQAANYFLLLVKESSWSHALYTYFAAAC 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393660  81 QGATGDV-------DGAQLVLKEVQKLFKR---KNNQIEQFSVKKAERFRKQTPTRALCVLASIEVLYLWKALPNCSFPN 150
Cdd:pfam10300 348 LLMLYREeeapaakERAVELFREVPTLKQKiagKSLPLEKFAARKVQRFKARTPADAVLVSPLLELIYFWNGFSRMGKKP 427

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1720393660 151 LQRMSQACH--------------EVDDSSvvgLKHLLLGAIHKCL 181
Cdd:pfam10300 428 LLTESVLKLiekalkanptseaqEPDDKC---LKQLLKGLCLRHL 469
Cohesin_load pfam10345
Cohesin loading factor; Cohesin_load is a common cohesin loading factor protein that is ...
 6-137 4.38e-04

Cohesin loading factor; Cohesin_load is a common cohesin loading factor protein that is conserved in fungi. It is associated with the cohesin complex and is required in G1 for cohesin binding to chromosomes but dispensable in G2 when cohesion has been established. It is referred to as both Ssl3, in pombe, and Scc4, in S.cerevisiae. It complexes with Mis4.


Pssm-ID: 463053 [Multi-domain]  Cd Length: 585  Bit Score: 41.15  E-value: 4.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393660   6 RIQRLECQINSALTSFHTALELAVDQREIQHVCLYEIGWCSMIELNFKDAFDSFERLKNESRWS--------QCYYAYLT 77
Cdd:pfam10345 325 LLEKLLSSLRPPSLSLSDASSKILWRRSLRCYLLIYQAFAACVRSDWTKANEFLNALHKLLKKSelqlpgslTPLLHYLL 404

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720393660  78 AVCQGATGDVDGAqlvlkevQKLFKRKNNQIEQFSVKKAERFRkqtpTRALCVLASIEVL 137
Cdd:pfam10345 405 GLYAQGTGDLEAA-------LAIYVSPLLSLLPSPSKTTALDI----PRELAILAALNLI 453
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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