|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
1-196 |
8.46e-88 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 280.25 E-value: 8.46e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVMNKTDIGRIPGSRVTVLGYGLLTTDAE 80
Cdd:cd18010 25 MGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKSKDGLRDGDAKVVIVSYDLLRRLEK 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 81 TLLDalntQNFRVVIVDESHYMKSRTAARSKILLPMVQKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRY 160
Cdd:cd18010 105 QLLA----RKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRY 180
|
170 180 190
....*....|....*....|....*....|....*..
gi 1720354805 161 CNAHvryFGKRRQWDCrGASNLSELHQLL-NDIMIRR 196
Cdd:cd18010 181 CAAK---QGGFGWDYS-GSSNLEELHLLLlATIMIRR 213
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
1-404 |
1.03e-82 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 282.50 E-value: 1.03e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEE---WPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVMN-KTDIGRIPGSRVTVLGYGLLT 76
Cdd:COG0553 269 MGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTRErAKGANPFEDADLVITSYGLLR 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 77 TDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILlpMVQKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEY 156
Cdd:COG0553 349 RDIELLAA----VDWDLVILDEAQHIKNPATKRAKAV--RALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAF 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 157 AKRYCNAHVRYfgkrrqwdcrGASNLSELHQLLNDIMIRRLKSEVLSQLPPKVRQRIPFDLPPA------AVKElnasfE 230
Cdd:COG0553 423 RERFARPIEKG----------DEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEqralyeAVLE-----Y 487
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 231 EWQKLMRAPNSGAMETVMGLITRMfKQTAI----------------AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQAC 294
Cdd:COG0553 488 LRRELEGAEGIRRRGLILAALTRL-RQICShpallleegaelsgrsAKLEALLELLEELLAEGE-KVLVFSQFTDTLDLL 565
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 295 TEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRI 374
Cdd:COG0553 566 EERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRI 645
|
410 420 430
....*....|....*....|....*....|
gi 1720354805 375 GQCSSVNIHYLIANGTLDSLMWAMLNRKAQ 404
Cdd:COG0553 646 GQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
261-386 |
1.51e-44 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 157.25 E-value: 1.51e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 261 AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAA 340
Cdd:cd18793 11 GKLEALLELLEELREPGE-KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1720354805 341 GQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLI 386
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
1-209 |
9.32e-30 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 120.10 E-value: 9.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-IAYFYKEE----WPLLIVVPSSLRYPWIEELEKWipeLEPEEINVVM---NKTDIGRIPGSRVTVLGY 72
Cdd:pfam00176 26 MGLGKTLQTISlLLYLKHVDknwgGPTLIVVPLSLLHNWMNEFERW---VSPPALRVVVlhgNKRPQERWKNDPNFLADF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 73 GLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQK 149
Cdd:pfam00176 103 DVVITTYETLRkhkELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSL--KTRNRWILTGTPLQNNLEELWALLNFLRPGP 180
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 150 FGTWIEYAKRYCNAHVRYFGKRRQWdcrgasnlsELHQLLNDIMIRRLKSEVLSQLPPKV 209
Cdd:pfam00176 181 FGSLSTFRNWFDRPIERGGGKKGVS---------RLHKLLKPFLLRRTKKDVEKSLPPKV 231
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
1-382 |
1.29e-20 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 98.33 E-value: 1.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-IAYFYKEE---WPLLIVVPSSLRYPWIEELEKWIPELE-------PEEINVVMNKTdigRIPGsrvtv 69
Cdd:PLN03142 197 MGLGKTLQTISlLGYLHEYRgitGPHMVVAPKSTLGNWMNEIRRFCPVLRavkfhgnPEERAHQREEL---LVAG----- 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 70 lGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRPEELFMQIEALF 146
Cdd:PLN03142 269 -KFDVCVTSFEMAIkekTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR--LLITGTPLQNNLHELWALLNFLL 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 147 PQKFGTwieyakrycnahvryFGKRRQWDCRGASN-----LSELHQLLNDIMIRRLKSEVLSQLPPKVRQRIPFDLPPAA 221
Cdd:PLN03142 346 PEIFSS---------------AETFDEWFQISGENdqqevVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQ 410
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 222 VKELNASFeewQKLMRAPNSGA-----METVMGL-------------------ITRMFKQTAIAKAGAVKDYIKMLLQND 277
Cdd:PLN03142 411 KQYYKALL---QKDLDVVNAGGerkrlLNIAMQLrkccnhpylfqgaepgppyTTGEHLVENSGKMVLLDKLLPKLKERD 487
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 278 SlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTR-VAILSIQAAGQGLTFTAASHVVFAE 356
Cdd:PLN03142 488 S-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADIVILYD 566
|
410 420
....*....|....*....|....*.
gi 1720354805 357 LYWDPGHIKQAEDRAHRIGQCSSVNI 382
Cdd:PLN03142 567 SDWNPQVDLQAQDRAHRIGQKKEVQV 592
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
270-375 |
6.41e-15 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 71.47 E-value: 6.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 270 IKMLLQNDSLKFLVFAHHLSMLQaCTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVaILSIQAAGQGLTFTAA 349
Cdd:pfam00271 7 LELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDV-LVATDVAERGLDLPDV 83
|
90 100
....*....|....*....|....*.
gi 1720354805 350 SHVVFAELYWDPGHIKQAEDRAHRIG 375
Cdd:pfam00271 84 DLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
1-152 |
5.81e-14 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 71.75 E-value: 5.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQA-IAIAYFYKEE--WPLLIVVPS-SLRYPWIEELEKWIPELEPEEINVV--MNKTDIGRIPGSRVTVLgygL 74
Cdd:smart00487 33 TGSGKTLAAlLPALEALKRGkgGRVLVLVPTrELAEQWAEELKKLGPSLGLKVVGLYggDSKREQLRKLESGKTDI---L 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 75 LTTDaETLLDAL-----NTQNFRVVIVDESHYMKSRTAARS-KILLPMVQKARRAILLTGTPALGRPE--ELFMQIEALF 146
Cdd:smart00487 110 VTTP-GRLLDLLendklSLSNVDLVILDEAHRLLDGGFGDQlEKLLKLLPKNVQLLLLSATPPEEIENllELFLNDPVFI 188
|
....*.
gi 1720354805 147 PQKFGT 152
Cdd:smart00487 189 DVGFTP 194
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
304-375 |
6.00e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 64.93 E-value: 6.00e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720354805 304 RYIRIDGSVPSSERIHLVNQFQKDPdtRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIG 375
Cdd:smart00490 13 KVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
2-355 |
1.46e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 61.96 E-value: 1.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 2 GLGKTIQAIAIAYFYKEEWPLLIVVPS-SLRYPWIEELEKWIPelepeEINVVMNKTDIGRipgsRVTVLGYGLLTTDAE 80
Cdd:COG1061 110 GTGKTVLALALAAELLRGKRVLVLVPRrELLEQWAEELRRFLG-----DPLAGGGKKDSDA----PITVATYQSLARRAH 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 81 tlLDALNtQNFRVVIVDESHymksRTAARS-KILLPMVQKARRaILLTGTPAL--GRPEELFMqiealfpqkfgtwieya 157
Cdd:COG1061 181 --LDELG-DRFGLVIIDEAH----HAGAPSyRRILEAFPAAYR-LGLTATPFRsdGREILLFL----------------- 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 158 krycnahvrYFGKRRQWDcrgasnlseLHQLLNDIMIRrlksevlsqlPPKVRQRipfdlppaavkelnasFEEWQKLMR 237
Cdd:COG1061 236 ---------FDGIVYEYS---------LKEAIEDGYLA----------PPEYYGI----------------RVDLTDERA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 238 apnsgAMETVMGLITRMFKQTAIAKAGAVKDYIKMLLQNDslKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSER 317
Cdd:COG1061 272 -----EYDALSERLREALAADAERKDKILRELLREHPDDR--KTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKER 344
|
330 340 350
....*....|....*....|....*....|....*...
gi 1720354805 318 IHLVNQFQKDPDTrvAILSIQAAGQGLTFTAASHVVFA 355
Cdd:COG1061 345 EEILEAFRDGELR--ILVTVDVLNEGVDVPRLDVAILL 380
|
|
| HNHc |
cd00085 |
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ... |
914-979 |
7.44e-08 |
|
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.
Pssm-ID: 238038 [Multi-domain] Cd Length: 57 Bit Score: 49.78 E-value: 7.44e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720354805 914 KSHRKSLLNAAWTAKLPLEqlnemlrnPGEGHFWQVDHIRPVyEGGGQCSLDNLQTLCTVCHKERT 979
Cdd:cd00085 1 RSHRLVLLARDGLCPYCGK--------PGGTEGLEVDHIIPL-SDGGNNDLDNLVLLCRKCHRKKH 57
|
|
| McrA |
COG1403 |
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms]; |
883-976 |
6.93e-06 |
|
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
Pssm-ID: 441013 [Multi-domain] Cd Length: 64 Bit Score: 44.59 E-value: 6.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 883 LRAQVFATEHGVCQHCGvdaqelflrmrdapkshrksllnaawtaklpleqlnemlrNPGEGHFWQVDHIRPVYEGGGQc 962
Cdd:COG1403 10 LRRAVLKRDNGRCQYCG----------------------------------------RPFSGDALEVDHIIPRSRGGTD- 48
|
90
....*....|....
gi 1720354805 963 SLDNLQTLCTVCHK 976
Cdd:COG1403 49 TWENLVLLCRRCNR 62
|
|
| HNH |
pfam01844 |
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ... |
946-981 |
8.75e-06 |
|
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.
Pssm-ID: 396422 [Multi-domain] Cd Length: 47 Bit Score: 43.49 E-value: 8.75e-06
10 20 30
....*....|....*....|....*....|....*.
gi 1720354805 946 FWQVDHIRPVYEGGGQcSLDNLQTLCTVCHKERTAQ 981
Cdd:pfam01844 13 ALTVDHIIPLSDGGAD-DIENLILLCPSCHNKKHNR 47
|
|
| HNHc |
smart00507 |
HNH nucleases; |
947-975 |
2.33e-04 |
|
HNH nucleases;
Pssm-ID: 214702 [Multi-domain] Cd Length: 52 Bit Score: 39.75 E-value: 2.33e-04
10 20
....*....|....*....|....*....
gi 1720354805 947 WQVDHIRPvYEGGGQCSLDNLQTLCTVCH 975
Cdd:smart00507 24 LEVDHIIP-LSDGGNDDLDNLVLLCPKCH 51
|
|
| ZnF_RBZ |
smart00547 |
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ... |
561-583 |
8.75e-04 |
|
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.
Pssm-ID: 197784 [Multi-domain] Cd Length: 25 Bit Score: 37.68 E-value: 8.75e-04
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
259-376 |
4.93e-03 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 40.67 E-value: 4.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 259 AIAKAGAVKDYIKMLLQNDSLKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVAIlSIQ 338
Cdd:PRK01297 316 AVAGSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGF-REGKIRVLV-ATD 393
|
90 100 110
....*....|....*....|....*....|....*...
gi 1720354805 339 AAGQGLTFTAASHVVFAELYWDPghikqaEDRAHRIGQ 376
Cdd:PRK01297 394 VAGRGIHIDGISHVINFTLPEDP------DDYVHRIGR 425
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
1-196 |
8.46e-88 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 280.25 E-value: 8.46e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVMNKTDIGRIPGSRVTVLGYGLLTTDAE 80
Cdd:cd18010 25 MGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKSKDGLRDGDAKVVIVSYDLLRRLEK 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 81 TLLDalntQNFRVVIVDESHYMKSRTAARSKILLPMVQKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEYAKRY 160
Cdd:cd18010 105 QLLA----RKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRY 180
|
170 180 190
....*....|....*....|....*....|....*..
gi 1720354805 161 CNAHvryFGKRRQWDCrGASNLSELHQLL-NDIMIRR 196
Cdd:cd18010 181 CAAK---QGGFGWDYS-GSSNLEELHLLLlATIMIRR 213
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
1-404 |
1.03e-82 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 282.50 E-value: 1.03e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEE---WPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVMN-KTDIGRIPGSRVTVLGYGLLT 76
Cdd:COG0553 269 MGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRELAKFAPGLRVLVLDGTRErAKGANPFEDADLVITSYGLLR 348
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 77 TDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILlpMVQKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEY 156
Cdd:COG0553 349 RDIELLAA----VDWDLVILDEAQHIKNPATKRAKAV--RALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAF 422
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 157 AKRYCNAHVRYfgkrrqwdcrGASNLSELHQLLNDIMIRRLKSEVLSQLPPKVRQRIPFDLPPA------AVKElnasfE 230
Cdd:COG0553 423 RERFARPIEKG----------DEEALERLRRLLRPFLLRRTKEDVLKDLPEKTEETLYVELTPEqralyeAVLE-----Y 487
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 231 EWQKLMRAPNSGAMETVMGLITRMfKQTAI----------------AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQAC 294
Cdd:COG0553 488 LRRELEGAEGIRRRGLILAALTRL-RQICShpallleegaelsgrsAKLEALLELLEELLAEGE-KVLVFSQFTDTLDLL 565
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 295 TEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRI 374
Cdd:COG0553 566 EERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRI 645
|
410 420 430
....*....|....*....|....*....|
gi 1720354805 375 GQCSSVNIHYLIANGTLDSLMWAMLNRKAQ 404
Cdd:COG0553 646 GQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
261-386 |
1.51e-44 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 157.25 E-value: 1.51e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 261 AKAGAVKDYIKMLLQNDSlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTRVAILSIQAA 340
Cdd:cd18793 11 GKLEALLELLEELREPGE-KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 1720354805 341 GQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLI 386
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
1-209 |
9.32e-30 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 120.10 E-value: 9.32e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-IAYFYKEE----WPLLIVVPSSLRYPWIEELEKWipeLEPEEINVVM---NKTDIGRIPGSRVTVLGY 72
Cdd:pfam00176 26 MGLGKTLQTISlLLYLKHVDknwgGPTLIVVPLSLLHNWMNEFERW---VSPPALRVVVlhgNKRPQERWKNDPNFLADF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 73 GLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQK 149
Cdd:pfam00176 103 DVVITTYETLRkhkELLKKVHWHRIVLDEGHRLKNSKSKLSKALKSL--KTRNRWILTGTPLQNNLEELWALLNFLRPGP 180
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 150 FGTWIEYAKRYCNAHVRYFGKRRQWdcrgasnlsELHQLLNDIMIRRLKSEVLSQLPPKV 209
Cdd:pfam00176 181 FGSLSTFRNWFDRPIERGGGKKGVS---------RLHKLLKPFLLRRTKKDVEKSLPPKV 231
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
1-148 |
9.08e-28 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 110.73 E-value: 9.08e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEE----WPLLIVVPSSLRYPWIEELEKWIPEL-------EPEEINVVMNKTDIGRipgSRVTV 69
Cdd:cd17919 28 MGLGKTLQAIAFLAYLLKEgkerGPVLVVCPLSVLENWEREFEKWTPDLrvvvyhgSQRERAQIRAKEKLDK---FDVVL 104
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720354805 70 LGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQ 148
Cdd:cd17919 105 TTYETLRRDKASLRK----FRWDLVVVDEAHRLKNPKSQLSKALKAL--RAKRRLLLTGTPLQNNLEELWALLDFLDPP 177
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
1-198 |
1.45e-23 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 99.95 E-value: 1.45e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-IAYFYKEEW--PLLIVVPSSLRYPWIEELEKWIPELEPeeinVVMNKTD-----IGRIPGSRVTVLGY 72
Cdd:cd18012 32 MGLGKTLQTLAlLLSRKEEGRkgPSLVVAPTSLIYNWEEEAAKFAPELKV----LVIHGTKrkrekLRALEDYDLVITSY 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 73 GLLTTDaetlLDALNTQNFRVVIVDESHYMKSRTAARSKILlpMVQKARRAILLTGTPALGRPEELFMQIEALFPQKFGT 152
Cdd:cd18012 108 GLLRRD----IELLKEVKFHYLVLDEAQNIKNPQTKTAKAV--KALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGS 181
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1720354805 153 WIEYAKRYCNAHVRYFGKRRqwdcrgasnLSELHQLLNDIMIRRLK 198
Cdd:cd18012 182 YKRFKKRFAKPIEKDGDEEA---------LEELKKLISPFILRRLK 218
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
1-382 |
1.29e-20 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 98.33 E-value: 1.29e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-IAYFYKEE---WPLLIVVPSSLRYPWIEELEKWIPELE-------PEEINVVMNKTdigRIPGsrvtv 69
Cdd:PLN03142 197 MGLGKTLQTISlLGYLHEYRgitGPHMVVAPKSTLGNWMNEIRRFCPVLRavkfhgnPEERAHQREEL---LVAG----- 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 70 lGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRPEELFMQIEALF 146
Cdd:PLN03142 269 -KFDVCVTSFEMAIkekTALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR--LLITGTPLQNNLHELWALLNFLL 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 147 PQKFGTwieyakrycnahvryFGKRRQWDCRGASN-----LSELHQLLNDIMIRRLKSEVLSQLPPKVRQRIPFDLPPAA 221
Cdd:PLN03142 346 PEIFSS---------------AETFDEWFQISGENdqqevVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKVGMSQMQ 410
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 222 VKELNASFeewQKLMRAPNSGA-----METVMGL-------------------ITRMFKQTAIAKAGAVKDYIKMLLQND 277
Cdd:PLN03142 411 KQYYKALL---QKDLDVVNAGGerkrlLNIAMQLrkccnhpylfqgaepgppyTTGEHLVENSGKMVLLDKLLPKLKERD 487
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 278 SlKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFQKDPDTR-VAILSIQAAGQGLTFTAASHVVFAE 356
Cdd:PLN03142 488 S-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLATADIVILYD 566
|
410 420
....*....|....*....|....*.
gi 1720354805 357 LYWDPGHIKQAEDRAHRIGQCSSVNI 382
Cdd:PLN03142 567 SDWNPQVDLQAQDRAHRIGQKKEVQV 592
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
1-196 |
2.84e-20 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 90.77 E-value: 2.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA----IAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPelepeeINVVM-----------------NKTDI 59
Cdd:cd17995 28 MGLGKTIQSIAflehLYQVEGIRGPFLVIAPLSTIPNWQREFETWTD------MNVVVyhgsgesrqiiqqyemyFKDAQ 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 60 GRiPGSRV---TVlgygLLTTdAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALG 133
Cdd:cd17995 102 GR-KKKGVykfDV----LITT-YEMVIadaEELRKIPWRVVVVDEAHRLKNRNSKLLQGLKKLTLEHK--LLLTGTPLQN 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720354805 134 RPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSELHQLLNDIMIRR 196
Cdd:cd17995 174 NTEELWSLLNFLEPEKFPSSEEFLEEFG-------------DLKTAEQVEKLQALLKPYMLRR 223
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
2-150 |
3.95e-20 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 89.66 E-value: 3.95e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 2 GLGKTIQAIAIAyfyKEEW------PLLIVVPSSLRYPWIEELEK--WIPELEPEEINVVMNKTDIGRIPGSR-VTVLGY 72
Cdd:cd18011 27 GLGKTIEAGLII---KELLlrgdakRVLILCPASLVEQWQDELQDkfGLPFLILDRETAAQLRRLIGNPFEEFpIVIVSL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 73 GLLTTDaETLLDALNTQNFRVVIVDESHYMKSRTAA----RSKILLPMVQKARRAILLTGTPALGRPEELFMQIEALFPQ 148
Cdd:cd18011 104 DLLKRS-EERRGLLLSEEWDLVVVDEAHKLRNSGGGketkRYKLGRLLAKRARHVLLLTATPHNGKEEDFRALLSLLDPG 182
|
..
gi 1720354805 149 KF 150
Cdd:cd18011 183 RF 184
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
1-150 |
1.07e-18 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 85.13 E-value: 1.07e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-IAYFYK--EEWPLLIVVPSSLRYPWIEELEKWIPEL----------EPEEI--NVVMNKTDIGripgs 65
Cdd:cd17998 28 MGLGKTIQVIAfLAYLKEigIPGPHLVVVPSSTLDNWLREFKRWCPSLkvepyygsqeERKHLryDILKGLEDFD----- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 66 rVTVLGYGLLTTDAE--TLLDalnTQNFRVVIVDESHYMKSRTAARSKILlpMVQKARRAILLTGTPALGRPEELFMQIE 143
Cdd:cd17998 103 -VIVTTYNLATSNPDdrSFFK---RLKLNYVVYDEGHMLKNMTSERYRHL--MTINANFRLLLTGTPLQNNLLELMSLLN 176
|
....*..
gi 1720354805 144 ALFPQKF 150
Cdd:cd17998 177 FIMPKPF 183
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
1-196 |
6.37e-18 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 84.29 E-value: 6.37e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-IAYFYKEEW---PLLIVVPSSLRYPWIEELEKWIPelepeEINVVMNKTDIgripGSRVTV------- 69
Cdd:cd18054 48 MGLGKTIQTISfLSYLFHQHQlygPFLLVVPLSTLTSWQREFEIWAP-----EINVVVYIGDL----MSRNTIreyewih 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 70 -----LGYGLLTTDAETLLD---ALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRPEELFMQ 141
Cdd:cd18054 119 sqtkrLKFNALITTYEILLKdktVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHR--LLITGTPLQNSLKELWSL 196
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1720354805 142 IEALFPQKFGTWIEYAKRYcnahvryfGKRRQwdcrgaSNLSELHQLLNDIMIRR 196
Cdd:cd18054 197 LHFIMPEKFEFWEDFEEDH--------GKGRE------NGYQSLHKVLEPFLLRR 237
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
1-196 |
1.48e-16 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 79.86 E-value: 1.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEE---W-PLLIVVPSSLRYPWIEELEKWIPELE-------PEEINVVMN----KTDIGRIPGS 65
Cdd:cd18002 28 MGLGKTVQSIAVLAHLAEEhniWgPFLVIAPASTLHNWQQEISRFVPQFKvlpywgnPKDRKVLRKfwdrKNLYTRDAPF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 66 RVTVLGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEAL 145
Cdd:cd18002 108 HVVITSYQLVVQDEKY----FQRVKWQYMVLDEAQAIKSSSSSRWKTLLSF--HCRNRLLLTGTPIQNSMAELWALLHFI 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720354805 146 FPQKFGTWIEYAKrycnahvrYFGKRRQWDCRGASNLSE-----LHQLLNDIMIRR 196
Cdd:cd18002 182 MPTLFDSHDEFNE--------WFSKDIESHAENKTGLNEhqlkrLHMILKPFMLRR 229
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
1-196 |
2.65e-16 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 78.94 E-value: 2.65e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-IAYFYKEEW---PLLIVVPSSLRYPWIEELEKWIPELepeeiNVVmnkTDIGRIpGSRVTVLGY---- 72
Cdd:cd17993 29 MGLGKTVQTISfLSYLFHSQQqygPFLVVVPLSTMPAWQREFAKWAPDM-----NVI---VYLGDI-KSRDTIREYefyf 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 73 ---------GLLTTDAETLLD--ALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRPEELFMQ 141
Cdd:cd17993 100 sqtkklkfnVLLTTYEIILKDkaFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFKTNNR--LLITGTPLQNSLKELWAL 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1720354805 142 IEALFPQKFGTWIEYAKRYCNAHVRYfgkrrqwdcrgasnLSELHQLLNDIMIRR 196
Cdd:cd17993 178 LHFLMPGKFDIWEEFEEEHDEEQEKG--------------IADLHKELEPFILRR 218
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
1-198 |
5.63e-16 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 78.18 E-value: 5.63e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-IAYFY---KEEWPLLIVVPSSLRYPWIEELEKWIPELE-------PEEinvvmNKTDIGRIPGSRVTV 69
Cdd:cd17996 31 MGLGKTIQTISlITYLMekkKNNGPYLVIVPLSTLSNWVSEFEKWAPSVSkivykgtPDV-----RKKLQSQIRAGKFNV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 70 lgygLLTTDAETLLD--ALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQkARRAILLTGTPALGRPEELFMQIEALFP 147
Cdd:cd17996 106 ----LLTTYEYIIKDkpLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTYYH-ARYRLLLTGTPLQNNLPELWALLNFLLP 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1720354805 148 QKFGTwIEYAKRYCNAHVRYFGKRRQWDCRGASNL---SELHQLLNDIMIRRLK 198
Cdd:cd17996 181 KIFKS-CKTFEQWFNTPFANTGEQVKIELNEEETLliiRRLHKVLRPFLLRRLK 233
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
1-196 |
9.75e-16 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 76.71 E-value: 9.75e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPELEpeeinVVMnktdigrIPGSRVTVLGYGLLT 76
Cdd:cd17994 28 MGLGKTIQTIVFLYsLYKEghsKGPFLVSAPLSTIINWEREFEMWAPDFY-----VVT-------YVGDHVLLTSYELIS 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 77 TDAETLldalNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGTWIEY 156
Cdd:cd17994 96 IDQAIL----GSIDWAVLVVDEAHRLKNNQSKFFRILNSY--KIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGF 169
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1720354805 157 AKRYCNahvryFGKRRQwdcrgasnLSELHQLLNDIMIRR 196
Cdd:cd17994 170 LEEFAD-----ISKEDQ--------IKKLHDLLGPHMLRR 196
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
1-208 |
2.61e-15 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 76.63 E-value: 2.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELepEEINVVMNKTDIGR------IPGS-RVTV 69
Cdd:cd18064 43 MGLGKTLQTISLLGYMKHyrniPGPHMVLVPKSTLHNWMAEFKRWVPTL--RAVCLIGDKDQRAAfvrdvlLPGEwDVCV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 70 LGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQK 149
Cdd:cd18064 121 TSYEMLIKEKSV----FKKFNWRYLVIDEAHRIKNEKSKLSEIVREF--KTTNRLLLTGTPLQNNLHELWALLNFLLPDV 194
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 150 FGTWIEYAKrycnahvrYFGKRrqwDCRGASNLSE-LHQLLNDIMIRRLKSEVLSQLPPK 208
Cdd:cd18064 195 FNSAEDFDS--------WFDTN---NCLGDQKLVErLHMVLRPFLLRRIKADVEKSLPPK 243
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
1-198 |
3.38e-15 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 75.82 E-value: 3.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELepeeiNVVM---NKTDIGRIPGSRVTVLGYG 73
Cdd:cd17997 31 MGLGKTLQTISLLGYLKHykniNGPHLIIVPKSTLDNWMREFKRWCPSL-----RVVVligDKEERADIIRDVLLPGKFD 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 74 LLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRPEELFMQIEALFPQKF 150
Cdd:cd17997 106 VCITSYEMVIkekTVLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNR--LLLTGTPLQNNLHELWALLNFLLPDVF 183
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1720354805 151 GTWIEYakrycnahvryfgkrRQW----DCRGASN--LSELHQLLNDIMIRRLK 198
Cdd:cd17997 184 TSSEDF---------------DEWfnvnNCDDDNQevVQRLHKVLRPFLLRRIK 222
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
270-375 |
6.41e-15 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 71.47 E-value: 6.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 270 IKMLLQNDSLKFLVFAHHLSMLQaCTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVaILSIQAAGQGLTFTAA 349
Cdd:pfam00271 7 LELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDV-LVATDVAERGLDLPDV 83
|
90 100
....*....|....*....|....*.
gi 1720354805 350 SHVVFAELYWDPGHIKQAEDRAHRIG 375
Cdd:pfam00271 84 DLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
1-196 |
1.82e-14 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 74.24 E-value: 1.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAyfykeeWPLL--------------IVVPSSLRYPWIEELEKWIPE-------LEPEEINVVMNKTDI 59
Cdd:cd18004 33 MGLGKTLQAIALV------WTLLkqgpygkptakkalIVCPSSLVGNWKAEFDKWLGLrrikvvtADGNAKDVKASLDFF 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 60 GRIPGSRVTVLGYGLLTTDAETLldaLNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELF 139
Cdd:cd18004 107 SSASTYPVLIISYETLRRHAEKL---SKKISIDLLICDEGHRLKNSESKTTKALNSL--PCRRRLLLTGTPIQNDLDEFF 181
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354805 140 MQIEALFPQKFGTWIEYAKRY-----------CNAHVRYFGKRRQWdcrgasnlsELHQLLNDIMIRR 196
Cdd:cd18004 182 ALVDFVNPGILGSLASFRKVFeepilrsrdpdASEEDKELGAERSQ---------ELSELTSRFILRR 240
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
1-152 |
2.71e-14 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 73.57 E-value: 2.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAI------------------AYFYKEEW------PLLIVVPSSLRYPWIEELEKWiPELEPEEINVVMNK 56
Cdd:cd18005 28 MGLGKTVQVIAFlaavlgktgtrrdrennrPRFKKKPPassakkPVLIVAPLSVLYNWKDELDTW-GHFEVGVYHGSRKD 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 57 tdigRIPGSRVTVLGYGLLTTDAETL---LDALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALG 133
Cdd:cd18005 107 ----DELEGRLKAGRLEVVVTTYDTLrrcIDSLNSINWSAVIADEAHRIKNPKSKLTQAMKELKCKVR--IGLTGTLLQN 180
|
170
....*....|....*....
gi 1720354805 134 RPEELFMQIEALFPQKFGT 152
Cdd:cd18005 181 NMKELWCLLDWAVPGALGS 199
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
1-152 |
5.81e-14 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 71.75 E-value: 5.81e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQA-IAIAYFYKEE--WPLLIVVPS-SLRYPWIEELEKWIPELEPEEINVV--MNKTDIGRIPGSRVTVLgygL 74
Cdd:smart00487 33 TGSGKTLAAlLPALEALKRGkgGRVLVLVPTrELAEQWAEELKKLGPSLGLKVVGLYggDSKREQLRKLESGKTDI---L 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 75 LTTDaETLLDAL-----NTQNFRVVIVDESHYMKSRTAARS-KILLPMVQKARRAILLTGTPALGRPE--ELFMQIEALF 146
Cdd:smart00487 110 VTTP-GRLLDLLendklSLSNVDLVILDEAHRLLDGGFGDQlEKLLKLLPKNVQLLLLSATPPEEIENllELFLNDPVFI 188
|
....*.
gi 1720354805 147 PQKFGT 152
Cdd:smart00487 189 DVGFTP 194
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
1-130 |
7.67e-14 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 72.32 E-value: 7.67e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEEWPL----LIVVPSSLRYPWIEELEKWIP-ELEPEEINVVMN--KTDIGRIP--------GS 65
Cdd:cd18007 35 MGLGKTLQVITFLHTYLAAAPRrsrpLVLCPASTLYNWEDEFKKWLPpDLRPLLVLVSLSasKRADARLRkinkwhkeGG 114
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720354805 66 rVTVLGYGL---LTTDAET---------LLDALNTQNfrVVIVDESHYMKSRTAARSKILlpMVQKARRAILLTGTP 130
Cdd:cd18007 115 -VLLIGYELfrnLASNATTdprlkqefiAALLDPGPD--LLVLDEGHRLKNEKSQLSKAL--SKVKTKRRILLTGTP 186
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
1-196 |
9.52e-14 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 71.93 E-value: 9.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-----------IAYFYKEEWPL----------LIVVPSSLRYPWIEELEKWIpelEPEEINVVM----- 54
Cdd:cd18008 23 MGLGKTIQALAlilatrpqdpkIPEELEENSSDpkklylskttLIVVPLSLLSQWKDEIEKHT---KPGSLKVYVyhgsk 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 55 NKTDIGRIPGSRVTVLGYGLLTTD------------AETLLDALNTQNFRVVIVDESHYMKSRTAARSKillpMVQ--KA 120
Cdd:cd18008 100 RIKSIEELSDYDIVITTYGTLASEfpknkkgggrdsKEKEASPLHRIRWYRVILDEAHNIKNRSTKTSR----AVCalKA 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 121 RRAILLTGTPALGRPEELFMQIealfpqKFGtwieyakrycnaHVRYFGKRRQWDCRGASNLSE--------LHQLLNDI 192
Cdd:cd18008 176 ERRWCLTGTPIQNSLDDLYSLL------RFL------------RVEPFGDYPWFNSDISKPFSKndrkalerLQALLKPI 237
|
....
gi 1720354805 193 MIRR 196
Cdd:cd18008 238 LLRR 241
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
1-198 |
1.04e-13 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 71.65 E-value: 1.04e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEE--W-PLLIVVPSSLRYPWIEELEKWIPEL----------EPEEINVVMNKTDiGRIPGSRV 67
Cdd:cd18009 31 MGLGKTIQTIALLAHLRERgvWgPFLVIAPLSTLPNWVNEFARFTPSVpvllyhgtkeERERLRKKIMKRE-GTLQDFPV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 68 TVLGYGLLTTDAetllDALNTQNFRVVIVDESHYMKSrtaARSKIL--LPMVQKARRaILLTGTPALGRPEELFMQIEAL 145
Cdd:cd18009 110 VVTSYEIAMRDR----KALQHYAWKYLIVDEGHRLKN---LNCRLIqeLKTFNSDNR-LLLTGTPLQNNLSELWSLLNFL 181
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 1720354805 146 FPQKFGTWIEYAKRY----CNAhvRYFGKRRQWDCRGASNLSELHQLLNDIMIRRLK 198
Cdd:cd18009 182 LPDVFDDLSSFESWFdfssLSD--NAADISNLSEEREQNIVHMLHAILKPFLLRRLK 236
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
1-197 |
1.68e-13 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 70.84 E-value: 1.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAI-AYF--YKEEW-PLLIVVPSSLRYPWIEELEKWIPEL----------EPEEINVVMNKTDigripGSR 66
Cdd:cd18003 28 MGLGKTIQTIALlAHLacEKGNWgPHLIVVPTSVMLNWEMEFKRWCPGFkiltyygsakERKLKRQGWMKPN-----SFH 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 67 VTVLGYGLLTTDAEtlldALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALF 146
Cdd:cd18003 103 VCITSYQLVVQDHQ----VFKRKKWKYLILDEAHNIKNFKSQRWQTLLNF--NTQRRLLLTGTPLQNSLMELWSLMHFLM 176
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1720354805 147 PQKFGTWIEYakrycnahvryfgkrRQWDCRGASNLSELHQLLNDIMIRRL 197
Cdd:cd18003 177 PHIFQSHQEF---------------KEWFSNPLTAMSEGSQEENEELVRRL 212
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
1-196 |
3.11e-13 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 70.46 E-value: 3.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAY---------FYKEEWPLLIVVPSSLRYPWIEELEKWIPELEPEEINVVMNKTDIGRIPG----SRV 67
Cdd:cd17999 28 MGLGKTLQTLCILAsdhhkransFNSENLPSLVVCPPTLVGHWVAEIKKYFPNAFLKPLAYVGPPQERRRLREqgekHNV 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 68 TVLGYGLLTTDAETLLDalntQNFRVVIVDESHYMKSrtaARSKILLPMVQ-KARRAILLTGTPALGRPEELFMQIEALF 146
Cdd:cd17999 108 IVASYDVLRNDIEVLTK----IEWNYCVLDEGHIIKN---SKTKLSKAVKQlKANHRLILSGTPIQNNVLELWSLFDFLM 180
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720354805 147 PQKFGTWIEYAKRYcnahVRYFGKRRQWDC------RGASNLSELHQLLNDIMIRR 196
Cdd:cd17999 181 PGYLGTEKQFQRRF----LKPILASRDSKAsakeqeAGALALEALHKQVLPFLLRR 232
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
304-375 |
6.00e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 64.93 E-value: 6.00e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720354805 304 RYIRIDGSVPSSERIHLVNQFQKDPdtRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIG 375
Cdd:smart00490 13 KVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
1-198 |
1.72e-12 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 68.55 E-value: 1.72e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEE----WPLLIVVPSSLRYPWIEELEKWIPELEPEEI--NVVMNKTDIGRIPGSRVTVlgygL 74
Cdd:cd18063 51 MGLGKTIQTIALITYLMEHkrlnGPYLIIVPLSTLSNWTYEFDKWAPSVVKISYkgTPAMRRSLVPQLRSGKFNV----L 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 75 LTTDAETLLDA--LNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARRaILLTGTPALGRPEELFMQIEALFPQKFGT 152
Cdd:cd18063 127 LTTYEYIIKDKhiLAKIRWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRR-ILLTGTPLQNKLPELWALLNFLLPTIFKS 205
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1720354805 153 WIEYaKRYCNAHVRYFGKRRQWDCRGAS-NLSELHQLLNDIMIRRLK 198
Cdd:cd18063 206 CSTF-EQWFNAPFAMTGERVDLNEEETIlIIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
1-196 |
1.86e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 68.15 E-value: 1.86e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-IAYFYKEEW---PLLIVVPSSLRYPWIEELEKWIPELepeeiNVVMNKTDIGRIPGSRV--------T 68
Cdd:cd18053 48 MGLGKTIQTISfLNYLFHEHQlygPFLLVVPLSTLTSWQREIQTWAPQM-----NAVVYLGDINSRNMIRThewmhpqtK 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 69 VLGYGLLTTDAETLLDA---LNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEAL 145
Cdd:cd18053 123 RLKFNILLTTYEILLKDksfLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDF--KSNHRLLITGTPLQNSLKELWSLLHFI 200
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1720354805 146 FPQKFGTWIEYAKRYcnahvryfGKRRQwdcrgaSNLSELHQLLNDIMIRR 196
Cdd:cd18053 201 MPEKFSSWEDFEEEH--------GKGRE------YGYASLHKELEPFLLRR 237
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
1-160 |
2.83e-12 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 67.56 E-value: 2.83e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEEWP---------LLIVVPSSLRYPWIEELEKWipeLEPEEINVVMNKTD-----IGRIPGSR 66
Cdd:cd18066 33 MGLGKTLQCISLIWTLLRQGPyggkpvikrALIVTPGSLVKNWKKEFQKW---LGSERIKVFTVDQDhkveeFIASPLYS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 67 VTVLGYGLLTTDaetlLDALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALF 146
Cdd:cd18066 110 VLIISYEMLLRS----LDQISKLNFDLVICDEGHRLKNTSIKTTTALTSL--SCERRIILTGTPIQNDLQEFFALIDFVN 183
|
170
....*....|....
gi 1720354805 147 PQKFGTWIEYAKRY 160
Cdd:cd18066 184 PGILGSLSTYRKVY 197
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
1-196 |
6.19e-12 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 66.31 E-value: 6.19e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAI----AYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELE------PEEINVVMNKtDIGRIPGSRVtvl 70
Cdd:cd18006 28 MGLGKTCQTISLlwylAGRLKLLGPFLVLCPLSVLDNWKEELNRFAPDLSvitymgDKEKRLDLQQ-DIKSTNRFHV--- 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 71 gygLLTTDAETLLDA--LNTQNFRVVIVDESHYMKSRTAARSKILLPmvQKARRAILLTGTPALGRPEELFMQIEALFPQ 148
Cdd:cd18006 104 ---LLTTYEICLKDAsfLKSFPWASLVVDEAHRLKNQNSLLHKTLSE--FSVDFRLLLTGTPIQNSLQELYALLSFIEPN 178
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1720354805 149 KFGtwIEYAKRYcnahVRYFGKRRqwdcRGASNLSELHQLLNDIMIRR 196
Cdd:cd18006 179 VFP--KDKLDDF----IKAYSETD----DESETVEELHLLLQPFLLRR 216
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
1-162 |
1.48e-11 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 65.68 E-value: 1.48e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAY--FYKEEWP----LLIVVPSSLRYPWIEELEKWIPELEPEEINVVMNKTDIGRIPGSR-------- 66
Cdd:cd18068 37 MGLGKTLQVVTFLHtvLLCEKLEnfsrVLVVCPLNTVLNWLNEFEKWQEGLKDEEKIEVNELATYKRPQERSyklqrwqe 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 67 ---VTVLGYGL---LTTD---------AETLLDALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPA 131
Cdd:cd18068 117 eggVMIIGYDMyriLAQErnvksreklKEIFNKALVDPGPDFVVCDEGHILKNEASAVSKAMNSI--RTKRRIVLTGTPL 194
|
170 180 190
....*....|....*....|....*....|.
gi 1720354805 132 LGRPEELFMQIEALFPQKFGTWIEYAKRYCN 162
Cdd:cd18068 195 QNNLIEYHCMVNFVKPNLLGTIKEFRNRFVN 225
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
1-198 |
1.76e-11 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 65.45 E-value: 1.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELepeeINVVMNKTDIGR---IPGSR-----VT 68
Cdd:cd18062 51 MGLGKTIQTIALITYLMEhkriNGPFLIIVPLSTLSNWVYEFDKWAPSV----VKVSYKGSPAARrafVPQLRsgkfnVL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 69 VLGYGLLTTDAETLLDAlntqNFRVVIVDESHYMKSRTAARSKILLPMVQKARRaILLTGTPALGRPEELFMQIEALFPQ 148
Cdd:cd18062 127 LTTYEYIIKDKQILAKI----RWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRR-LLLTGTPLQNKLPELWALLNFLLPT 201
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 1720354805 149 KFGTWIEYaKRYCNAHVRYFGKRRQWDCRGAS-NLSELHQLLNDIMIRRLK 198
Cdd:cd18062 202 IFKSCSTF-EQWFNAPFAMTGEKVDLNEEETIlIIRRLHKVLRPFLLRRLK 251
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
1-196 |
3.20e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 64.30 E-value: 3.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAI---AYFYKEEWPLLIVVPSSLRYPWIEELEKWIpelepeEINVVMN-----------------KTDIG 60
Cdd:cd18060 28 MGLGKTIQSIAFlqeVYNVGIHGPFLVIAPLSTITNWEREFNTWT------EMNTIVYhgslasrqmiqqyemycKDSRG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 61 R-IPGSrvtvLGYGLLTTDAETLLD---ALNTQNFRVVIVDESHYMKSRTAarsKIL--LPMVQKARRaILLTGTPALGR 134
Cdd:cd18060 102 RlIPGA----YKFDALITTFEMILSdcpELREIEWRCVIIDEAHRLKNRNC---KLLdsLKHMDLEHK-VLLTGTPLQNT 173
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1720354805 135 PEELFMQIEALFPQKFGTWIEYakrycnahVRYFGkrrqwDCRGASNLSELHQLLNDIMIRR 196
Cdd:cd18060 174 VEELFSLLHFLEPSQFPSESEF--------LKDFG-----DLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
1-198 |
3.46e-11 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 64.27 E-value: 3.46e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKE----EWPLLIVVPSSLRYPWIEELEKWIPELE------PEEINVVMNKTDIgrIPGS-RVTV 69
Cdd:cd18065 43 MGLGKTLQTIALLGYLKHyrniPGPHMVLVPKSTLHNWMNEFKRWVPSLRavcligDKDARAAFIRDVM--MPGEwDVCV 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 70 LGYGLLTTDAETlldaLNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEALFPQK 149
Cdd:cd18065 121 TSYEMVIKEKSV----FKKFNWRYLVIDEAHRIKNEKSKLSEIVREF--KTTNRLLLTGTPLQNNLHELWALLNFLLPDV 194
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1720354805 150 FGTWIEYAKrycnahvrYFGKRrqwDCRGASNLSE-LHQLLNDIMIRRLK 198
Cdd:cd18065 195 FNSADDFDS--------WFDTK---NCLGDQKLVErLHAVLKPFLLRRIK 233
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
1-160 |
3.83e-11 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 64.07 E-value: 3.83e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEEWPL---LIVVPSSLRYPWIEELEKWIPelEPEEINVVMNKTdigripgSRVTVLGYGLLTT 77
Cdd:cd18069 37 MGLGKTLQVISFLDVLLRHTGAktvLAIVPVNTLQNWLSEFNKWLP--PPEALPNVRPRP-------FKVFILNDEHKTT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 78 DAETLLDA----------LNTQNFR------VVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQ 141
Cdd:cd18069 108 AARAKVIEdwvkdggvllMGYEMFRlrpgpdVVICDEGHRIKNCHASTSQALKNI--RSRRRIVLTGYPLQNNLIEYWCM 185
|
170
....*....|....*....
gi 1720354805 142 IEALFPQKFGTWIEYAKRY 160
Cdd:cd18069 186 VDFVRPDFLGTRQEFSNMF 204
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
1-196 |
5.35e-11 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 64.03 E-value: 5.35e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYKEEWP--------LLIVVPSSLRYPWIEELEKWI-PELEPEEINVVMNKTDIGRIPGS---RVT 68
Cdd:cd18067 33 MGLGKTLQCITLMWTLLRQSPqckpeidkAIVVSPSSLVKNWANELGKWLgGRLQPLAIDGGSKKEIDRKLVQWasqQGR 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 69 VLGYGLLTTDAETL---LDALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFMQIEAL 145
Cdd:cd18067 113 RVSTPVLIISYETFrlhVEVLQKGEVGLVICDEGHRLKNSDNQTYQALDSL--NTQRRVLLSGTPIQNDLSEYFSLVNFV 190
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354805 146 FPQKFGTWIEYAKRYCNAHVRyfG-------KRRQwdcRGASNLSELHQLLNDIMIRR 196
Cdd:cd18067 191 NPGILGTAAEFKKNFELPILK--GrdadaseKERQ---LGEEKLQELISIVNRCIIRR 243
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
1-130 |
5.97e-11 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 63.54 E-value: 5.97e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA-IAYFYKEEW--PLLIVVPSSLRYPWIEELEKWIPELEPEE---INVVMNKTDIGRIPGSRVTVLG-YG 73
Cdd:cd18001 28 MGLGKTVQICAfLSGMFDSGLikSVLVVMPTSLIPHWVKEFAKWTPGLRVKVfhgTSKKERERNLERIQRGGGVLLTtYG 107
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1720354805 74 LLTTDAETlLDALNTQNFR--VVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTP 130
Cdd:cd18001 108 MVLSNTEQ-LSADDHDEFKwdYVILDEGHKIKNSKTKSAKSLREIPAKNR--IILTGTP 163
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
1-140 |
1.45e-10 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 62.49 E-value: 1.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAYFYkeewPLLIVVPSSLRYPWIEELEKWIpelEPEEINVVM----NKT-DIGRIPGSRVTVLGYGLL 75
Cdd:cd18071 57 MGLGKTLTTISLILAN----FTLIVCPLSVLSNWETQFEEHV---KPGQLKVYTyhggERNrDPKLLSKYDIVLTTYNTL 129
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720354805 76 TTDAETLLDA-LNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFM 140
Cdd:cd18071 130 ASDFGAKGDSpLHTINWLRVVLDEGHQIRNPNAQQTKAVLNL--SSERRWVLTGTPIQNSPKDLGS 193
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
1-147 |
2.09e-10 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 61.19 E-value: 2.09e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIA----IAYFYKEEWPLLIVVPSSLRYPWIEELEKWIPELEpeeiNVVMNKTDIGRIPGS----------- 65
Cdd:cd18000 28 MGLGKTIQIIAflaaLHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFR----VVVLHSSGSGTGSEEklgsierksql 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 66 -RVTVLGYGLLTTDAETLL---DALNTQNFRVVIVDESHYMKSRTAARSKIL--LPMVQKarraILLTGTPALGRPEELF 139
Cdd:cd18000 104 iRKVVGDGGILITTYEGFRkhkDLLLNHNWQYVILDEGHKIRNPDAEITLACkqLRTPHR----LILSGTPIQNNLKELW 179
|
....*...
gi 1720354805 140 MQIEALFP 147
Cdd:cd18000 180 SLFDFVFP 187
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
1-196 |
5.71e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 60.85 E-value: 5.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPEL----------------EPE---EINVVMNKT 57
Cdd:cd18057 28 MGLGKTVQTIVFLYsLYKEghsKGPYLVSAPLSTIINWEREFEMWAPDFyvvtytgdkesrsvirENEfsfEDNAIRSGK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 58 DIGRIPGS-----RVTVLGYGLLTTDAETLldalNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPAL 132
Cdd:cd18057 108 KVFRMKKEaqikfHVLLTSYELITIDQAIL----GSIEWACLVVDEAHRLKNNQSKFFRVLNSY--KIDYKLLLTGTPLQ 181
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720354805 133 GRPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSELHQLLNDIMIRR 196
Cdd:cd18057 182 NNLEELFHLLNFLTPERFNNLEGFLEEFA-------------DISKEDQIKKLHDLLGPHMLRR 232
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
2-355 |
1.46e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 61.96 E-value: 1.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 2 GLGKTIQAIAIAYFYKEEWPLLIVVPS-SLRYPWIEELEKWIPelepeEINVVMNKTDIGRipgsRVTVLGYGLLTTDAE 80
Cdd:COG1061 110 GTGKTVLALALAAELLRGKRVLVLVPRrELLEQWAEELRRFLG-----DPLAGGGKKDSDA----PITVATYQSLARRAH 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 81 tlLDALNtQNFRVVIVDESHymksRTAARS-KILLPMVQKARRaILLTGTPAL--GRPEELFMqiealfpqkfgtwieya 157
Cdd:COG1061 181 --LDELG-DRFGLVIIDEAH----HAGAPSyRRILEAFPAAYR-LGLTATPFRsdGREILLFL----------------- 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 158 krycnahvrYFGKRRQWDcrgasnlseLHQLLNDIMIRrlksevlsqlPPKVRQRipfdlppaavkelnasFEEWQKLMR 237
Cdd:COG1061 236 ---------FDGIVYEYS---------LKEAIEDGYLA----------PPEYYGI----------------RVDLTDERA 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 238 apnsgAMETVMGLITRMFKQTAIAKAGAVKDYIKMLLQNDslKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSER 317
Cdd:COG1061 272 -----EYDALSERLREALAADAERKDKILRELLREHPDDR--KTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKER 344
|
330 340 350
....*....|....*....|....*....|....*...
gi 1720354805 318 IHLVNQFQKDPDTrvAILSIQAAGQGLTFTAASHVVFA 355
Cdd:COG1061 345 EEILEAFRDGELR--ILVTVDVLNEGVDVPRLDVAILL 380
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
1-196 |
2.28e-09 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 58.90 E-value: 2.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAY---FYKEEWPLLIVVPSSLRYPWIEELEKWIpelepeEIN-VVMNKTDIgripgSRVTVLGY---- 72
Cdd:cd18058 28 MGLGKTIQSITFLSeifLMGIRGPFLIIAPLSTITNWEREFRTWT------EMNaIVYHGSQI-----SRQMIQQYemyy 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 73 ---------------GLLTTDAETLLDA--LNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKARraILLTGTPALGRP 135
Cdd:cd18058 97 rdeqgnplsgifkfqVVITTFEMILADCpeLKKINWSCVIIDEAHRLKNRNCKLLEGLKLMALEHK--VLLTGTPLQNSV 174
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1720354805 136 EELFMQIEALFPQKFGTWIEYAKRycnahvryFGkrrqwDCRGASNLSELHQLLNDIMIRR 196
Cdd:cd18058 175 EELFSLLNFLEPSQFPSETTFLEE--------FG-----DLKTEEQVKKLQSILKPMMLRR 222
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
1-162 |
4.19e-09 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 57.74 E-value: 4.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKT---IQAIAIAYFYKEEWPLLIVVPSSL-RYPWIEELEKWipELEPEEINVVMNKTDIGRIP----GSRVTVLGY 72
Cdd:cd18013 24 MGLGKTvttLTALSDLQLDDFTRRVLVIAPLRVaRSTWPDEVEKW--NHLRNLTVSVAVGTERQRSKaantPADLYVINR 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 73 GLLttdaETLLDALNTQ-NFRVVIVDESHYMKSRTAARSKILLPMVQKARRAILLTGTPALGRPEELFMQIEAL-FPQKF 150
Cdd:cd18013 102 ENL----KWLVNKSGDPwPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKRLIGLTGTPSPNGLMDLWAQIALLdQGERL 177
|
170
....*....|...
gi 1720354805 151 GTWIE-YAKRYCN 162
Cdd:cd18013 178 GRSITaYRERWFD 190
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
1-196 |
5.95e-09 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 57.35 E-value: 5.95e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAY-FYKE--EWPLLIVVPSSLRYPWIEELEKWIpelepeEINVVMNKTDIG------------RIPGS 65
Cdd:cd18059 28 MGLGKTIQSITFLYeIYLKgiHGPFLVIAPLSTIPNWEREFRTWT------ELNVVVYHGSQAsrrtiqlyemyfKDPQG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 66 RVTVLGY---GLLTTDAETLLDALNTQN--FRVVIVDESHYMKSRTAarsKIL--LPMVQKARRaILLTGTPALGRPEEL 138
Cdd:cd18059 102 RVIKGSYkfhAIITTFEMILTDCPELRNipWRCVVIDEAHRLKNRNC---KLLegLKMMDLEHK-VLLTGTPLQNTVEEL 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354805 139 FMQIEALFPQKFGTWIEYAKRycnahvryFGkrrqwDCRGASNLSELHQLLNDIMIRR 196
Cdd:cd18059 178 FSLLHFLEPSRFPSETTFMQE--------FG-----DLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
1-196 |
8.11e-09 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 57.38 E-value: 8.11e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPEL----------------EPE---EINVVMNKT 57
Cdd:cd18056 28 MGLGKTVQTAVFLYsLYKEghsKGPFLVSAPLSTIINWEREFEMWAPDMyvvtyvgdkdsraiirENEfsfEDNAIRGGK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 58 DIGRIPGS-----RVTVLGYGLLTTDaetlLDALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPAL 132
Cdd:cd18056 108 KASRMKKEasvkfHVLLTSYELITID----MAILGSIDWACLIVDEAHRLKNNQSKFFRVLNGY--SLQHKLLLTGTPLQ 181
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720354805 133 GRPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSELHQLLNDIMIRR 196
Cdd:cd18056 182 NNLEELFHLLNFLTPERFHNLEGFLEEFA-------------DIAKEDQIKKLHDMLGPHMLRR 232
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
1-196 |
9.68e-09 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 56.94 E-value: 9.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAY-FYKE---EWPLLIVVPSSLRYPWIEELEKWIPEL----------------EPE---EINVVMNKT 57
Cdd:cd18055 28 MGLGKTIQTIVFLYsLYKEghtKGPFLVSAPLSTIINWEREFQMWAPDFyvvtytgdkdsraiirENEfsfDDNAVKGGK 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 58 DIGRIPGS-----RVTVLGYGLLTTDAetllDALNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPAL 132
Cdd:cd18055 108 KAFKMKREaqvkfHVLLTSYELVTIDQ----AALGSIRWACLVVDEAHRLKNNQSKFFRVLNGY--KIDHKLLLTGTPLQ 181
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720354805 133 GRPEELFMQIEALFPQKFGTWIEYAKRYCnahvryfgkrrqwDCRGASNLSELHQLLNDIMIRR 196
Cdd:cd18055 182 NNLEELFHLLNFLTPERFNNLEGFLEEFA-------------DISKEDQIKKLHDLLGPHMLRR 232
|
|
| HNHc |
cd00085 |
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ... |
914-979 |
7.44e-08 |
|
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.
Pssm-ID: 238038 [Multi-domain] Cd Length: 57 Bit Score: 49.78 E-value: 7.44e-08
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720354805 914 KSHRKSLLNAAWTAKLPLEqlnemlrnPGEGHFWQVDHIRPVyEGGGQCSLDNLQTLCTVCHKERT 979
Cdd:cd00085 1 RSHRLVLLARDGLCPYCGK--------PGGTEGLEVDHIIPL-SDGGNNDLDNLVLLCRKCHRKKH 57
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
1-196 |
1.70e-07 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 53.09 E-value: 1.70e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQAIAIAY-FYKE--EWPLLIVVPSSLRYPWIEELEKWIpelepeEINVVMNKTDI------------GRIPGS 65
Cdd:cd18061 28 MGLGKTIQSITFLYeILLTgiRGPFLIIAPLSTIANWEREFRTWT------DLNVVVYHGSLisrqmiqqyemyFRDSQG 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 66 RVTVLGYGL--LTTDAETLLDA---LNTQNFRVVIVDESHYMKSRTAARSKILLPMvqKARRAILLTGTPALGRPEELFM 140
Cdd:cd18061 102 RIIRGAYRFqaIITTFEMILGGcpeLNAIDWRCVIIDEAHRLKNKNCKLLEGLKLM--NLEHKVLLTGTPLQNTVEELFS 179
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 1720354805 141 QIEALFPQKFGTWieyakrycNAHVRYFGkrrqwDCRGASNLSELHQLLNDIMIRR 196
Cdd:cd18061 180 LLHFLEPLRFPSE--------STFMQEFG-----DLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
2-130 |
3.03e-07 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 50.77 E-value: 3.03e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 2 GLGKTIQAIA-IAYFYKEewPLLIVVPS-SLRYPWIEELEKWIPELEPEEINVVMNKTDIGRIpgsrVTVLGYGLLTTDA 79
Cdd:cd17926 28 GSGKTLTALAlIAYLKEL--RTLIVVPTdALLDQWKERFEDFLGDSSIGLIGGGKKKDFDDAN----VVVATYQSLSNLA 101
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1720354805 80 ETLLDALNtqNFRVVIVDESHYMKSRTAARskiLLPMVQKARRaILLTGTP 130
Cdd:cd17926 102 EEEKDLFD--QFGLLIVDEAHHLPAKTFSE---ILKELNAKYR-LGLTATP 146
|
|
| McrA |
COG1403 |
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms]; |
883-976 |
6.93e-06 |
|
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
Pssm-ID: 441013 [Multi-domain] Cd Length: 64 Bit Score: 44.59 E-value: 6.93e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 883 LRAQVFATEHGVCQHCGvdaqelflrmrdapkshrksllnaawtaklpleqlnemlrNPGEGHFWQVDHIRPVYEGGGQc 962
Cdd:COG1403 10 LRRAVLKRDNGRCQYCG----------------------------------------RPFSGDALEVDHIIPRSRGGTD- 48
|
90
....*....|....
gi 1720354805 963 SLDNLQTLCTVCHK 976
Cdd:COG1403 49 TWENLVLLCRRCNR 62
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
2-130 |
7.49e-06 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 47.28 E-value: 7.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 2 GLGKTIQAIAIAYFYKEEWPL---LIVVPS-SLRYPWIEELEKWIPELEPEEINVVMNKTDIGRiPGSRVTVLGYGLLTT 77
Cdd:pfam04851 33 GSGKTLTAAKLIARLFKKGPIkkvLFLVPRkDLLEQALEEFKKFLPNYVEIGEIISGDKKDESV-DDNKIVVTTIQSLYK 111
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1720354805 78 DAETLLDALNTQNFRVVIVDESHymksRTAARS-KILLPMVQKARRaILLTGTP 130
Cdd:pfam04851 112 ALELASLELLPDFFDVIIIDEAH----RSGASSyRNILEYFKPAFL-LGLTATP 160
|
|
| HNH |
pfam01844 |
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ... |
946-981 |
8.75e-06 |
|
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.
Pssm-ID: 396422 [Multi-domain] Cd Length: 47 Bit Score: 43.49 E-value: 8.75e-06
10 20 30
....*....|....*....|....*....|....*.
gi 1720354805 946 FWQVDHIRPVYEGGGQcSLDNLQTLCTVCHKERTAQ 981
Cdd:pfam01844 13 ALTVDHIIPLSDGGAD-DIENLILLCPSCHNKKHNR 47
|
|
| HNHc |
smart00507 |
HNH nucleases; |
947-975 |
2.33e-04 |
|
HNH nucleases;
Pssm-ID: 214702 [Multi-domain] Cd Length: 52 Bit Score: 39.75 E-value: 2.33e-04
10 20
....*....|....*....|....*....
gi 1720354805 947 WQVDHIRPvYEGGGQCSLDNLQTLCTVCH 975
Cdd:smart00507 24 LEVDHIIP-LSDGGNDDLDNLVLLCPKCH 51
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
2-131 |
6.55e-04 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 41.38 E-value: 6.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 2 GLGKTIQAIA--IAYFYKEEWPLLIVVPSSLRypwIEELEKWIPELEPEEINVVMNKTDIGRIPgsrVTVLGYGLLTtda 79
Cdd:cd17931 11 GAGKTTRVLPqiIREAIKKRLRTLVLAPTRVV---AAEMYEALRGLPIRYRTGAVKEEHGGNEI---VDYMCHGTFT--- 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1720354805 80 ETLLDALNTQNFRVVIVDESHYMKSRT-AARSKILLPMVQKARRAILLTGTPA 131
Cdd:cd17931 82 CRLLSPKRVPNYNLIIMDEAHFTDPASiAARGYIHTRVEMGEAAVIFMTATPP 134
|
|
| ZnF_RBZ |
smart00547 |
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ... |
561-583 |
8.75e-04 |
|
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.
Pssm-ID: 197784 [Multi-domain] Cd Length: 25 Bit Score: 37.68 E-value: 8.75e-04
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
1-129 |
1.38e-03 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 40.08 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 1 MGLGKTIQA--IAIAYFYKEEWPLLIVVP-SSLRYPWIEELEKWIPELEPEEINVVMN--KTDIG-RIPGSRVTVLGYGL 74
Cdd:cd00046 10 TGSGKTLAAllAALLLLLKKGKKVLVLVPtKALALQTAERLRELFGPGIRVAVLVGGSsaEEREKnKLGDADIIIATPDM 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 1720354805 75 LTTDAETLlDALNTQNFRVVIVDESHYMKSRTAARSKILLPMVQKAR---RAILLTGT 129
Cdd:cd00046 90 LLNLLLRE-DRLFLKDLKLIIVDEAHALLIDSRGALILDLAVRKAGLknaQVILLSAT 146
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
259-376 |
4.93e-03 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 40.67 E-value: 4.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720354805 259 AIAKAGAVKDYIKMLLQNDSLKFLVFAHHLSMLQACTEAVIESKSRYIRIDGSVPSSERIHLVNQFqKDPDTRVAIlSIQ 338
Cdd:PRK01297 316 AVAGSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKDGINAAQLSGDVPQHKRIKTLEGF-REGKIRVLV-ATD 393
|
90 100 110
....*....|....*....|....*....|....*...
gi 1720354805 339 AAGQGLTFTAASHVVFAELYWDPghikqaEDRAHRIGQ 376
Cdd:PRK01297 394 VAGRGIHIDGISHVINFTLPEDP------DDYVHRIGR 425
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
333-386 |
9.97e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 36.14 E-value: 9.97e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1720354805 333 AILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVnIHYLI 386
Cdd:cd18785 25 ILVATNVLGEGIDVPSLDTVIFFDPPSSAASYIQRVGRAGRGGKDEGE-VILFV 77
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