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Conserved domains on  [gi|1720414110|ref|XP_030110510|]
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vomeronasal receptor Vmn2r17 isoform X3 [Mus musculus]

Protein Classification

PBP1_Pheromone_receptor and 7tmC_V2R_pheromone domain-containing protein( domain architecture ID 11570772)

PBP1_Pheromone_receptor and 7tmC_V2R_pheromone domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
45-500 2.66e-170

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


:

Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 499.48  E-value: 2.66e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  45 DCGFFLFTSEEPIKEDFYHF---CIDFRIPARRYEVFLVMFFATDEINRNPYLLPNMSLIFCLIvgmcgDTLGYLEETHS 121
Cdd:cd06365     3 GGVFPIHTFSEGKKKDFKEPpspLLCFRFSIKYYQHLLAFLFAIEEINKNPDLLPNITLGFHIY-----DSCSSERLALE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 122 PNNTWNSI------NYNCEIRPICDIELTGPSWTTSVKLAIN---SRKPKVFFGPFNSHLSDHDQFPYIYQVATKDTHLS 192
Cdd:cd06365    78 SSLSILSGnsepipNYSCREQRKLVAFIGDLSSSTSVAMARIlglYKYPQISYGAFDPLLSDKVQFPSFYRTVPSDTSQS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 193 HGMVSLMLHFRWTWIGLVISDDDQSIQFLSDLREAMQRHGICLAFVNMIPENMQIYMTrgKIYDKQIMTSSAKVVIIYGE 272
Cdd:cd06365   158 LAIVQLLKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIPTNSSLKRI--IKYINQIIKSSANVIIIYGD 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 273 MNSTLEVSFRRWAYLCARRIWITTSQWDVITNKRDFSFDFFHGTVTFAHHNGEIVIFRNFLQTVNTSKYPLDISQTMQEW 352
Cdd:cd06365   236 TDSLLELLFRLWEQLVTGKVWITTSQWDISTLPFEFYLNLFNGTLGFSQHSGEIPGFKEFLQSVHPSKYPEDIFLKTLWE 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 353 NYFNCSISKNSNSKMDHFTFNNTLEWTALQKLNMVLSEEGYNLYNAVYAVAHTYHELILQQVEFQKMAEPKGIFTDCQQV 432
Cdd:cd06365   316 SYFNCKWPDQNCKSLQNCCGNESLETLDVHSFDMTMSRLSYNVYNAVYAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQL 395
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720414110 433 ASLLKTRVFTNPVGELVNMKHRENQCADYDIFNIWNFPQGLGLRVKIGSYYPCFPQNQQLHISEDL-EW 500
Cdd:cd06365   396 HHYLKKVQFTNPAGDEVNFDEKGDLPTKYDILNWQIFPNGTGTKVKVGTFDPSAPSGQQLIINDSMiEW 464
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
541-792 1.75e-145

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


:

Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 427.46  E-value: 1.75e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 541 PLGMALGCMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTV 620
Cdd:cd15283     1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 621 AISTVLAKTITVVMAFKLTAPGRRVRGMLVAGAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEHGKTILICNKGSV 700
Cdd:cd15283    81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 701 IAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAALLG 780
Cdd:cd15283   161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                         250
                  ....*....|..
gi 1720414110 781 FIFVPKCYVILV 792
Cdd:cd15283   241 CIFAPKCYIILL 252
 
Name Accession Description Interval E-value
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
45-500 2.66e-170

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 499.48  E-value: 2.66e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  45 DCGFFLFTSEEPIKEDFYHF---CIDFRIPARRYEVFLVMFFATDEINRNPYLLPNMSLIFCLIvgmcgDTLGYLEETHS 121
Cdd:cd06365     3 GGVFPIHTFSEGKKKDFKEPpspLLCFRFSIKYYQHLLAFLFAIEEINKNPDLLPNITLGFHIY-----DSCSSERLALE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 122 PNNTWNSI------NYNCEIRPICDIELTGPSWTTSVKLAIN---SRKPKVFFGPFNSHLSDHDQFPYIYQVATKDTHLS 192
Cdd:cd06365    78 SSLSILSGnsepipNYSCREQRKLVAFIGDLSSSTSVAMARIlglYKYPQISYGAFDPLLSDKVQFPSFYRTVPSDTSQS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 193 HGMVSLMLHFRWTWIGLVISDDDQSIQFLSDLREAMQRHGICLAFVNMIPENMQIYMTrgKIYDKQIMTSSAKVVIIYGE 272
Cdd:cd06365   158 LAIVQLLKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIPTNSSLKRI--IKYINQIIKSSANVIIIYGD 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 273 MNSTLEVSFRRWAYLCARRIWITTSQWDVITNKRDFSFDFFHGTVTFAHHNGEIVIFRNFLQTVNTSKYPLDISQTMQEW 352
Cdd:cd06365   236 TDSLLELLFRLWEQLVTGKVWITTSQWDISTLPFEFYLNLFNGTLGFSQHSGEIPGFKEFLQSVHPSKYPEDIFLKTLWE 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 353 NYFNCSISKNSNSKMDHFTFNNTLEWTALQKLNMVLSEEGYNLYNAVYAVAHTYHELILQQVEFQKMAEPKGIFTDCQQV 432
Cdd:cd06365   316 SYFNCKWPDQNCKSLQNCCGNESLETLDVHSFDMTMSRLSYNVYNAVYAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQL 395
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720414110 433 ASLLKTRVFTNPVGELVNMKHRENQCADYDIFNIWNFPQGLGLRVKIGSYYPCFPQNQQLHISEDL-EW 500
Cdd:cd06365   396 HHYLKKVQFTNPAGDEVNFDEKGDLPTKYDILNWQIFPNGTGTKVKVGTFDPSAPSGQQLIINDSMiEW 464
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
541-792 1.75e-145

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 427.46  E-value: 1.75e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 541 PLGMALGCMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTV 620
Cdd:cd15283     1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 621 AISTVLAKTITVVMAFKLTAPGRRVRGMLVAGAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEHGKTILICNKGSV 700
Cdd:cd15283    81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 701 IAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAALLG 780
Cdd:cd15283   161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                         250
                  ....*....|..
gi 1720414110 781 FIFVPKCYVILV 792
Cdd:cd15283   241 CIFAPKCYIILL 252
7tm_3 pfam00003
7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane ...
536-786 1.13e-79

7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.


Pssm-ID: 459626 [Multi-domain]  Cd Length: 247  Bit Score: 256.43  E-value: 1.13e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 536 LAYEDPLGMALGCMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNqATCILQQTTFG 615
Cdd:pfam00003   1 LDLSAPWGIVLEALAALGILLTLVLLVVFLLHRKTPIVKASNRSLSFLLLLGLLLLFLLAFLFIGKPT-VTCALRRFLFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 616 VFFTVAISTVLAKTITVVMAFKLTAPGRRVRGMLvagapnLAIPICTLIQIVLCGIWLVTsPPFIGRDTKSEhGKTILIC 695
Cdd:pfam00003  80 VGFTLCFSCLLAKTFRLVLIFRRRKPGPRGWQLL------LLALGLLLVQVIILTEWLID-PPFPEKDNLSE-GKIILEC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 696 NKGSVIAF-HFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVY-HSTRGKAM---VVVEVFS 770
Cdd:pfam00003 152 EGSTSIAFlDFVLAYVGLLLLAGFLLAFKTRKLPDNFNEAKFITFSMLLSVLIWVAFIPMYlYGNKGKGTwdpVALAIFA 231
                         250
                  ....*....|....*.
gi 1720414110 771 ILASSAALLGFIFVPK 786
Cdd:pfam00003 232 ILASGWVLLGLYFIPK 247
ANF_receptor pfam01094
Receptor family ligand binding region; This family includes extracellular ligand binding ...
77-466 9.40e-22

Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.


Pssm-ID: 460062 [Multi-domain]  Cd Length: 347  Bit Score: 97.46  E-value: 9.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  77 VFLVMFFATDEINRNPYLLPnmslifclivgmcGDTLGYLeethspnntwnsINYNCeirpiCDIELT------------ 144
Cdd:pfam01094   2 VLLAVRLAVEDINADPGLLP-------------GTKLEYI------------ILDTC-----CDPSLAlaaaldllkgev 51
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 145 ----GPSWTTSVKLAIN----SRKPKVFFGPFNSHLSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIGLVISDDDQ 216
Cdd:pfam01094  52 vaiiGPSCSSVASAVASlaneWKVPLISYGSTSPALSDLNRYPTFLRTTPSDTSQADAIVDILKHFGWKRVALIYSDDDY 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 217 SIQFLSDLREAMQRHGICLAFVNMIPENMQIymtrGKIYDK--QIMTSSAKVVII--YGEMNSTLEVSFRRWAYLCARRI 292
Cdd:pfam01094 132 GESGLQALEDALRERGIRVAYKAVIPPAQDD----DEIARKllKEVKSRARVIVVccSSETARRLLKAARELGMMGEGYV 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 293 WITTSQW-DVITNKRDFSFDFFHGTVTFAHHNGEIVIFRNFlqtvntskypldisqtmqewnyFNCSISKNSNSKmdhft 371
Cdd:pfam01094 208 WIATDGLtTSLVILNPSTLEAAGGVLGFRLHPPDSPEFSEF----------------------FWEKLSDEKELY----- 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 372 fnntlewTALQKLNMVLseeGYNLYNAVYAVAHTYHELILQQVEFQKMAEPkGIFTDCQQVASLLKTRVFTNpVGELVNM 451
Cdd:pfam01094 261 -------ENLGGLPVSY---GALAYDAVYLLAHALHNLLRDDKPGRACGAL-GPWNGGQKLLRYLKNVNFTG-LTGNVQF 328
                         410
                  ....*....|....*...
gi 1720414110 452 K---HRENqcADYDIFNI 466
Cdd:pfam01094 329 DengDRIN--PDYDILNL 344
 
Name Accession Description Interval E-value
PBP1_pheromone_receptor cd06365
Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within ...
45-500 2.66e-170

Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the V2R pheromone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptor, the GABAb receptor, the calcium-sensing receptor (CaSR), the T1R taste receptor, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380588 [Multi-domain]  Cd Length: 464  Bit Score: 499.48  E-value: 2.66e-170
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  45 DCGFFLFTSEEPIKEDFYHF---CIDFRIPARRYEVFLVMFFATDEINRNPYLLPNMSLIFCLIvgmcgDTLGYLEETHS 121
Cdd:cd06365     3 GGVFPIHTFSEGKKKDFKEPpspLLCFRFSIKYYQHLLAFLFAIEEINKNPDLLPNITLGFHIY-----DSCSSERLALE 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 122 PNNTWNSI------NYNCEIRPICDIELTGPSWTTSVKLAIN---SRKPKVFFGPFNSHLSDHDQFPYIYQVATKDTHLS 192
Cdd:cd06365    78 SSLSILSGnsepipNYSCREQRKLVAFIGDLSSSTSVAMARIlglYKYPQISYGAFDPLLSDKVQFPSFYRTVPSDTSQS 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 193 HGMVSLMLHFRWTWIGLVISDDDQSIQFLSDLREAMQRHGICLAFVNMIPENMQIYMTrgKIYDKQIMTSSAKVVIIYGE 272
Cdd:cd06365   158 LAIVQLLKHFGWTWVGLIISDDDYGEQFSQDLKKEMEKNGICVAFVEKIPTNSSLKRI--IKYINQIIKSSANVIIIYGD 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 273 MNSTLEVSFRRWAYLCARRIWITTSQWDVITNKRDFSFDFFHGTVTFAHHNGEIVIFRNFLQTVNTSKYPLDISQTMQEW 352
Cdd:cd06365   236 TDSLLELLFRLWEQLVTGKVWITTSQWDISTLPFEFYLNLFNGTLGFSQHSGEIPGFKEFLQSVHPSKYPEDIFLKTLWE 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 353 NYFNCSISKNSNSKMDHFTFNNTLEWTALQKLNMVLSEEGYNLYNAVYAVAHTYHELILQQVEFQKMAEPKGIFTDCQQV 432
Cdd:cd06365   316 SYFNCKWPDQNCKSLQNCCGNESLETLDVHSFDMTMSRLSYNVYNAVYAVAHALHEMLLCQPKTGPGNCSDRRNFQPWQL 395
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720414110 433 ASLLKTRVFTNPVGELVNMKHRENQCADYDIFNIWNFPQGLGLRVKIGSYYPCFPQNQQLHISEDL-EW 500
Cdd:cd06365   396 HHYLKKVQFTNPAGDEVNFDEKGDLPTKYDILNWQIFPNGTGTKVKVGTFDPSAPSGQQLIINDSMiEW 464
7tmC_V2R_pheromone cd15283
vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G ...
541-792 1.75e-145

vomeronasal type-2 pheromone receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 pheromone receptors (V2Rs). Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are coexpressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones.


Pssm-ID: 320410 [Multi-domain]  Cd Length: 252  Bit Score: 427.46  E-value: 1.75e-145
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 541 PLGMALGCMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTV 620
Cdd:cd15283     1 PLGIALTVLSLLGSVLTAAVLVVFIKHRDTPIVKANNSELSYLLLLSLKLCFLCSLLFIGQPSTWTCMLRQTAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 621 AISTVLAKTITVVMAFKLTAPGRRVRGMLVAGAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEHGKTILICNKGSV 700
Cdd:cd15283    81 CISCILAKTIVVVAAFKATRPGSNIMKWFGPGQQRAIIFICTLVQVVICAIWLATSPPFPDKNMHSEHGKIILECNEGSV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 701 IAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAALLG 780
Cdd:cd15283   161 VAFYCVLGYIGLLALVSFLLAFLARKLPDNFNEAKFITFSMLVFCAVWVAFVPAYISSPGKYMVAVEIFAILASSAGLLG 240
                         250
                  ....*....|..
gi 1720414110 781 FIFVPKCYVILV 792
Cdd:cd15283   241 CIFAPKCYIILL 252
7tmC_V2R_AA_sensing_receptor-like cd15044
vomeronasal type-2 pheromone receptors, amino acid-sensing receptors and closely related ...
541-791 1.03e-84

vomeronasal type-2 pheromone receptors, amino acid-sensing receptors and closely related proteins; member of the class C family of seven-transmembrane G protein-coupled receptors; This group is composed of vomeronasal type-2 pheromone receptors (V2Rs), a subgroup of broad-spectrum amino-acid sensing receptors including calcium-sensing receptor (CaSR) and GPRC6A, as well as their closely related proteins. Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are co-expressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, producing the second messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones. CaSR is a widely expressed GPCR that is involved in sensing small changes in extracellular levels of calcium ion to maintain a constant level of the extracellular calcium via modulating the synthesis and secretion of calcium regulating hormones, such as parathyroid hormone (PTH), in order to regulate Ca(2+)transport into or out of the extracellular fluid via kidney, intestine, and/or bone. For instance, when Ca2+ is high, CaSR downregulates PTH synthesis and secretion, leading to an increase in renal Ca2+ excretion, a decrease in intestinal Ca2+ absorption, and a reduction in release of skeletal Ca2+. GRPC6A (GPCR, class C, group 6, subtype A) is a widely expressed amino acid-sensing GPCR that is most closely related to CaSR. GPRC6A is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine and less potently by small aliphatic amino acids. Moreover, the receptor can be either activated or modulated by divalent cations such as Ca2+. GPRC6A is expressed in the testis, but not the ovary and specifically also binds to the osteoblast-derived hormone osteocalcin (OCN), which regulates testosterone production by the testis and male fertility independently of the hypothalamic-pituitary axis. Furthermore, GPRC6A knockout studies suggest that GRPC6A is involved in regulation of bone metabolism, male reproduction, energy homeostasis, glucose metabolism, and in activation of inflammation response, as well as prostate cancer growth and progression, among others.


Pssm-ID: 320172 [Multi-domain]  Cd Length: 251  Bit Score: 269.72  E-value: 1.03e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 541 PLGMALGCMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTV 620
Cdd:cd15044     1 PLGILLVILSILGIIFVLVVGGVFVRYRNTPIVKANNRELSYLILLSLFLCFSSSLFFIGEPQDWTCKLRQTMFGVSFTL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 621 AISTVLAKTITVVMAFKLTAPGRRVRGMlVAGAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEHGKTILICNKGSV 700
Cdd:cd15044    81 CISCILTKTLKVLLAFSADKPLTQKFLM-CLYLPILIVFTCTGIQVVICTVWLIFAPPTVEVNVSPLPRVIILECNEGSI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 701 IAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAALLG 780
Cdd:cd15044   160 LAFGTMLGYIAFLAFLCFLFAFKARKLPDNYNEAKFITFGMLVFFIVWISFVPAYLSTKGKFVVAVEIIAILASSYGLLG 239
                         250
                  ....*....|.
gi 1720414110 781 FIFVPKCYVIL 791
Cdd:cd15044   240 CIFLPKCYVIL 250
7tm_3 pfam00003
7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane ...
536-786 1.13e-79

7 transmembrane sweet-taste receptor of 3 GCPR; This is a domain of seven transmembrane regions that forms the C-terminus of some subclass 3 G-coupled-protein receptors. It is often associated with a downstream cysteine-rich linker domain, NCD3G pfam07562, which is the human sweet-taste receptor, and the N-terminal domain, ANF_receptor pfam01094. The seven TM regions assemble in such a way as to produce a docking pocket into which such molecules as cyclamate and lactisole have been found to bind and consequently confer the taste of sweetness.


Pssm-ID: 459626 [Multi-domain]  Cd Length: 247  Bit Score: 256.43  E-value: 1.13e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 536 LAYEDPLGMALGCMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNqATCILQQTTFG 615
Cdd:pfam00003   1 LDLSAPWGIVLEALAALGILLTLVLLVVFLLHRKTPIVKASNRSLSFLLLLGLLLLFLLAFLFIGKPT-VTCALRRFLFG 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 616 VFFTVAISTVLAKTITVVMAFKLTAPGRRVRGMLvagapnLAIPICTLIQIVLCGIWLVTsPPFIGRDTKSEhGKTILIC 695
Cdd:pfam00003  80 VGFTLCFSCLLAKTFRLVLIFRRRKPGPRGWQLL------LLALGLLLVQVIILTEWLID-PPFPEKDNLSE-GKIILEC 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 696 NKGSVIAF-HFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVY-HSTRGKAM---VVVEVFS 770
Cdd:pfam00003 152 EGSTSIAFlDFVLAYVGLLLLAGFLLAFKTRKLPDNFNEAKFITFSMLLSVLIWVAFIPMYlYGNKGKGTwdpVALAIFA 231
                         250
                  ....*....|....*.
gi 1720414110 771 ILASSAALLGFIFVPK 786
Cdd:pfam00003 232 ILASGWVLLGLYFIPK 247
7tmC_V2R-like cd15280
vomeronasal type-2 receptor-like proteins, member of the class C family of seven-transmembrane ...
541-793 4.33e-67

vomeronasal type-2 receptor-like proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; This group represents vomeronasal type-2 receptor-like proteins that are closely related to the V2R family of vomeronasal GPCRs. Members of the V2R family of vomeronasal GPCRs are involved in detecting protein pheromones for social and sexual cues between the same species. V2Rs and G-alpha(o) protein are coexpressed in the basal layer of the vomeronasal organ (VNO), which is the sensory organ of the accessory olfactory system present in amphibians, reptiles, and non-primate mammals such as mice and rodents, but it is non-functional or absent in humans, apes, and monkeys. On the other hand, members of the V1R receptor family and G-alpha(i2) protein are co-expressed in the apical neurons of the VNO. Activation of V1R or V2R causes activation of phospholipase pathway, generating the secondary messengers diacylglycerol (DAG) and IP3. However, in contrast to V1Rs, V2Rs contain the long N-terminal extracellular domain, which is believed to bind pheromones. Human V2R1-like protein, also known as putative calcium-sensing receptor-like 1 (CASRL1), is not included here because it is a nonfunctional pseudogene.


Pssm-ID: 320407 [Multi-domain]  Cd Length: 253  Bit Score: 223.12  E-value: 4.33e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 541 PLGMALGCMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTV 620
Cdd:cd15280     1 ALGITLIALSIFGALVVLAVTVVYIMHRHTPLVKANDRELSFLIQMSLVITFLTSILFIGKPENWSCMARQITLALGFSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 621 AISTVLAKTITVVMAFKLTAPGRRVRGMLVAGAPNLAIpICTLIQIVLCGIWLVTSPPFIGRDTKSEHGKTILICNKGSV 700
Cdd:cd15280    81 CLSSILGKTISLFLRYRASKSETRLDSMHPIYQKIIVL-ICVLIEVGICTAYLILEPPRMYKNTEVQNVKIIFECNEGSI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 701 IAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAALLG 780
Cdd:cd15280   160 EFLCSIFGFDVFLALLCFLTAFVARKLPDNFNEGKFITFGMLVFFIVWISFVPAYLSTRGKFKVAVEIFAILASSFGLLG 239
                         250
                  ....*....|...
gi 1720414110 781 FIFVPKCYVILVK 793
Cdd:cd15280   240 CIFVPKCYIILLK 252
7tm_classC_mGluR-like cd13953
metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled ...
541-791 4.62e-61

metabotropic glutamate receptor-like class C family of seven-transmembrane G protein-coupled receptors superfamily; The class C GPCRs consist of glutamate receptors (mGluR1-8), the extracellular calcium-sensing receptors (caSR), the gamma-amino-butyric acid type B receptors (GABA-B), the vomeronasal type-2 pheromone receptors (V2R), the type 1 taste receptors (TAS1R), and the promiscuous L-alpha-amino acid receptor (GPRC6A), as well as several orphan receptors. Structurally, these receptors are typically composed of a large extracellular domain containing a Venus flytrap module which possesses the orthosteric agonist-binding site, a cysteine-rich domain (CRD) with the exception of GABA-B receptors, and the seven-transmembrane domains responsible for G protein activation. Moreover, the Venus flytrap module shows high structural homology with bacterial periplasmic amino acid-binding proteins, which serve as primary receptors in transport of a variety of soluble substrates such as amino acids and polysaccharides, among many others. The class C GPCRs exist as either homo- or heterodimers, which are essential for their function. The GABA-B1 and GABA-B2 receptors form a heterodimer via interactions between the N-terminal Venus flytrap modules and the C-terminal coiled-coiled domains. On the other hand, heterodimeric CaSRs and Tas1Rs and homodimeric mGluRs utilize Venus flytrap interactions and intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD), which can also acts as a molecular link to mediate the signal between the Venus flytrap and the 7TMs. Furthermore, members of the class C GPCRs bind a variety of endogenous ligands, ranging from amino acids, ions, to pheromones and sugar molecules, and play important roles in many physiological processes such as synaptic transmission, calcium homeostasis, and the sensation of sweet and umami tastes.


Pssm-ID: 320091 [Multi-domain]  Cd Length: 251  Bit Score: 206.70  E-value: 4.62e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 541 PLGMALGCMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTV 620
Cdd:cd13953     1 PLAIVLLVLAALGLLLTIFIWVVFIRYRNTPVVKASNRELSYLLLFGILLCFLLAFLFLLPPSDVLCGLRRFLFGLSFTL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 621 AISTVLAKTITVVMAFKLTAPGRRVRGMLVAGAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSeHGKTILICNKGSV 700
Cdd:cd13953    81 VFSTLLVKTNRIYRIFKSGLRSSLRPKLLSNKSQLLLVLFLLLVQVAILIVWLILDPPKVEKVIDS-DNKVVELCCSTGN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 701 IAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAALLG 780
Cdd:cd13953   160 IGLILSLVYNILLLLICTYLAFKTRKLPDNFNEARYIGFSSLLSLVIWIAFIPTYFTTSGPYRDAILSFGLLLNATVLLL 239
                         250
                  ....*....|.
gi 1720414110 781 FIFVPKCYVIL 791
Cdd:cd13953   240 CLFLPKIYIIL 250
7tmC_CaSR cd15282
calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled ...
541-791 2.42e-59

calcium-sensing receptor, member of the class C of seven-transmembrane G protein-coupled receptors; CaSR is a widely expressed GPCR that is involved in sensing small changes in extracellular levels of calcium ion to maintain a constant level of the extracellular calcium via modulating the synthesis and secretion of calcium regulating hormones, such as parathyroid hormone (PTH), in order to regulate Ca(2+)transport into or out of the extracellular fluid via kidney, intestine, and/or bone. For instance, when Ca2+ is high, CaSR downregulates PTH synthesis and secretion, leading to an increase in renal Ca2+ excretion, a decrease in intestinal Ca2+ absorption, and a reduction in release of skeletal Ca2+. CaSR is coupled to both G(q/11)-dependent activation of phospholipase and, subsequently, intracellular calcium mobilization and protein kinase C activation as well as G(i/o)-dependent inhibition of adenylate cyclase leading to inhibition of cAMP formation. CaSR is closely related to GRPC6A (GPCR, class C, group 6, subtype A), which is an amino acid-sensing GPCR that is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine. These receptors contain a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD), and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TASR1 receptors.


Pssm-ID: 320409 [Multi-domain]  Cd Length: 252  Bit Score: 202.10  E-value: 2.42e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 541 PLGMALGCMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTV 620
Cdd:cd15282     1 PFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLICCFSSSLIFIGEPQDWTCRLRQPAFGISFVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 621 AISTVLAKTITVVMAFKLTAPGRRVRGMLVAGAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEHGKTILICNKGSV 700
Cdd:cd15282    81 CISCILVKTNRVLLVFEAKIPTSLHRKWWGLNLQFLLVFLCTFVQIVICVIWLYTAPPSSYRNHELEDEIIFITCNEGSL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 701 IAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAALLG 780
Cdd:cd15282   161 MALGFLIGYTCLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIAILASSFGLLA 240
                         250
                  ....*....|.
gi 1720414110 781 FIFVPKCYVIL 791
Cdd:cd15282   241 CIFFNKVYIIL 251
7tmC_GPRC6A cd15281
class C of seven-transmembrane G protein-coupled receptors, subtype 6A; GRPC6A (GPCR, class C, ...
558-791 3.29e-51

class C of seven-transmembrane G protein-coupled receptors, subtype 6A; GRPC6A (GPCR, class C, group 6, subtype A) is a widely expressed amino acid-sensing GPCR that is most closely related to CaSR. GPRC6A is most potently activated by the basic amino acids L-arginine, L-lysine, and L-ornithine and less potently by small aliphatic amino acids. Moreover, the receptor can be either activated or modulated by divalent cations such as Ca2+ and Mg2+. GPRC6A is expressed in the testis, but not the ovary and specifically also binds to the osteoblast-derived hormone osteocalcin (OCN), which regulates testosterone production by the testis and male fertility independently of the hypothalamic-pituitary axis. Furthermore, GPRC6A knockout studies suggest that GRPC6A is involved in regulation of bone metabolism, male reproduction, energy homeostasis, glucose metabolism, and in activation of inflammation response, as well as prostate cancer growth and progression, among others. GPRC6A has been suggested to couple to the Gq subtype of G proteins, leading to IP3 production and intracellular calcium mobilization. GPRC6A contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD), and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320408  Cd Length: 249  Bit Score: 179.59  E-value: 3.29e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 558 LLVFFT---FVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLAKTITVVM 634
Cdd:cd15281    15 LLIFFIsalFTKNLNTPVVKAGGGPLCYVILLSHFGSFISTVFFIGEPSDLTCKTRQTLFGISFTLCVSCILVKSLKILL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 635 AFKLTAPGRRVRGMLVAgaPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTkSEHGKTILICNKGSVIAFHFVLGYLGSLA 714
Cdd:cd15281    95 AFSFDPKLQELLKCLYK--PIMIVFICTGIQVIICTVWLVFYKPFVDKNF-SLPESIILECNEGSYVAFGLMLGYIALLA 171
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720414110 715 LGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAALLGFIFVPKCYVIL 791
Cdd:cd15281   172 FICFIFAFKGRKLPENYNEAKFITFGMLIYFIAWITFIPIYATTFGKYVPAVEMIVILISNYGILSCTFLPKCYIIL 248
PBP1_CaSR cd06364
ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors ...
65-500 7.62e-44

ligand-binding domain of the CaSR calcium-sensing receptor, a member of the family C receptors within the G-protein coupled receptor superfamily; Ligand-binding domain of the CaSR calcium-sensing receptor, which is a member of the family C receptors within the G-protein coupled receptor superfamily. CaSR provides feedback control of extracellular calcium homeostasis by responding sensitively to acute fluctuations in extracellular ionized Ca2+ concentration. This ligand-binding domain has homology to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). CaSR is widely expressed in mammalian tissues and is active in tissues that are not directly involved in extracellular calcium homeostasis. Moreover, CaSR responds to aromatic, aliphatic, and polar amino acids, but not to positively charged or branched chain amino acids, which suggests that changes in plasma amino acid levels are likely to modulate whole body calcium metabolism. Additionally, the family C GPCRs includes at least two receptors with broad-spectrum amino acid-sensing properties: GPRC6A which recognizes basic and various aliphatic amino acids, its gold-fish homolog the 5.24 chemoreceptor, and a specific taste receptor (T1R) which responds to aliphatic, polar, charged, and branched amino acids, but not to aromatic amino acids.


Pssm-ID: 380587 [Multi-domain]  Cd Length: 473  Bit Score: 165.51  E-value: 7.62e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  65 CIDFRIPARRYevFLVMFFATDEINRNPYLLPNMSLIFcLIVGMCGDTLGYLEETHSPNNTWNSI--NYNCEIRP--ICD 140
Cdd:cd06364    28 CEGFNFRGFRW--AQTMIFAIEEINNSPDLLPNITLGY-RIYDSCATISKALRAALALVNGQEETnlDERCSGGPpvAAV 104
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 141 IELTGPSWTTSVKLAInsrkpkvffGPFN----SH------LSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIGLV 210
Cdd:cd06364   105 IGESGSTLSIAVARTL---------GLFYipqvSYfascacLSDKKQFPSFLRTIPSDYYQSRALAQLVKHFGWTWVGAI 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 211 ISDDDQSIQFLSDLREAMQRHGICLAFVNMIPEnmqiYMTRGKIYD--KQIMTSSAKVVIIY---GEMNSTLEVSFRRwa 285
Cdd:cd06364   176 ASDDDYGRNGIKAFLEEAEKLGICIAFSETIPR----TYSQEKILRivEVIKKSTAKVIVVFsseGDLEPLIKELVRQ-- 249
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 286 yLCARRIWITTSQW--DVITNKRDFsFDFFHGTVTFAHHNGEIVIFRNFLQTVNTSKYPLDiSQTMQEWNY-FNCSISKN 362
Cdd:cd06364   250 -NITGRQWIASEAWitSSLLATPEY-FPVLGGTIGFAIRRGEIPGLKEFLLRVHPSKSPSN-PFVKEFWEEtFNCSLSSS 326
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 363 SNSKMDHF-----TFNNTLEWTALQKLNMVLSEEGYNLYNAVYAVAHTYHELIlqqvefqkMAEP-KGIFT--DC----- 429
Cdd:cd06364   327 SKSNSSSSsrppcTGSENLENVQNPYTDVSQLRISYNVYKAVYAIAHALHDLL--------QCEPgKGPFSngSCadikk 398
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720414110 430 ---QQVASLLKTRVFTNPVGELVNMKHRENQCADYDIFNiWNFPQGLGLR-VKIGSYYPCFPQNQQLHISED-LEW 500
Cdd:cd06364   399 vepWQLLYYLKHVNFTTKFGEEVYFDENGDPVASYDIIN-WQLSDDGTIQfVTVGYYDASAPSGEELVINESkILW 473
7tmC_TAS1R3 cd15290
type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G ...
555-791 2.86e-40

type 1 taste receptor subtype 3, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R3, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320417 [Multi-domain]  Cd Length: 253  Bit Score: 149.06  E-value: 2.86e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 555 ALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLAKT--ITV 632
Cdd:cd15290    15 VLQCSVGVLFLKHRGTPLVQASGGPLSIFALLSLMGACLSLLLFLGQPSDVVCRLQQPLNALFLTVCLSTILSISlqIFL 94
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 633 VMAFKLTAPGRRvrGMLVAGAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSE-HGKTILICNKGSVIAFHFVLGYLG 711
Cdd:cd15290    95 VTEFPKCAASHL--HWLRGPGSWLVVLICCLVQAGLCGWYVQDGPSLSEYDAKMTlFVEVFLRCPVEPWLGFGLMHGFNG 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 712 SLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAALLGFIFVPKCYVIL 791
Cdd:cd15290   173 ALALISFMCTFMAQKPLKQYNLARDITFSTLIYCVTWVIFIPIYAGLQVKLRSIAQVGFILLSNLGLLAAYYLPKCYLLL 252
7tmC_mGluRs cd15045
metabotropic glutamate receptors, member of the class C family of seven-transmembrane G ...
545-791 2.99e-37

metabotropic glutamate receptors, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group I mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to (Gi/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320173 [Multi-domain]  Cd Length: 253  Bit Score: 140.07  E-value: 2.99e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 545 ALGCMALCF--SALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAI 622
Cdd:cd15045     3 AIGAMAFASlgILLTLFVLVVFVRYRDTPVVKASGRELSYVLLAGILLSYVMTFVLVAKPSTIVCGLQRFGLGLCFTVCY 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 623 STVLAKTITVVMAFKLTAPGRRVRGMLvagAPNLAIPIC---TLIQIVLCGIWLVTSPPFIGRDTkSEHGKTILICNkgS 699
Cdd:cd15045    83 AAILTKTNRIARIFRLGKKSAKRPRFI---SPRSQLVITgllVSVQVLVLAVWLILSPPRATHHY-PTRDKNVLVCS--S 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 700 VIAFHFVLGYLGSLAL-GSFTV-AFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAA 777
Cdd:cd15045   157 ALDASYLIGLAYPILLiILCTVyAFKTRKIPEGFNEAKYIGFTMYTTCIIWLAFVPLYFTTASNIEVRITTLSVSISLSA 236
                         250
                  ....*....|....*.
gi 1720414110 778 L--LGFIFVPKCYVIL 791
Cdd:cd15045   237 TvqLACLFAPKVYIIL 252
7tmC_mGluR_group1 cd15285
metabotropic glutamate receptors in group 1, member of the class C family of ...
549-791 4.11e-36

metabotropic glutamate receptors in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320412  Cd Length: 250  Bit Score: 137.00  E-value: 4.11e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 549 MALCFSAL----TLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAIST 624
Cdd:cd15285     5 VAMVFACVgilaTLFVTVVFIRHNDTPVVKASTRELSYIILAGILLCYASTFALLAKPSTISCYLQRILPGLSFAMIYAA 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 625 VLAKT--ITVVMAFKLTAPGRRVRGMLVAGAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEhGKTILICNKgSVIA 702
Cdd:cd15285    85 LVTKTnrIARILAGSKKKILTRKPRFMSASAQVVITGILISVEVAIIVVMLILEPPDATLDYPTP-KRVRLICNT-STLG 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 703 FHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVveVFSILASSAALLGFI 782
Cdd:cd15285   163 FVVPLGFDFLLILLCTLYAFKTRNLPENFNEAKFIGFTMYTTCVIWLAFLPIYFGSDNKEITL--CFSVSLSATVALVFL 240

                  ....*....
gi 1720414110 783 FVPKCYVIL 791
Cdd:cd15285   241 FFPKVYIIL 249
7tmC_mGluR2 cd15447
metabotropic glutamate receptor 2 in group 2, member of the class C family of ...
552-791 9.56e-35

metabotropic glutamate receptor 2 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320563  Cd Length: 254  Bit Score: 133.13  E-value: 9.56e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 552 CFSAL-TLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLAKTI 630
Cdd:cd15447    11 CLGILsTLFVVGVFVKNNETPVVKASGRELCYILLLGVLLCYLMTFIFIAKPSTAVCTLRRLGLGTSFAVCYSALLTKTN 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 631 TVVMAFKLTAPG-RRVRGMlvagAPNLAIPICTLI---QIVLCGIWLVTSPPFIGRDTKSEHGKTI-LICNKGSViafhf 705
Cdd:cd15447    91 RIARIFSGAKDGaQRPRFI----SPASQVAICLALiscQLLVVLIWLLVEAPGTRKETAPERRYVVtLKCNSRDS----- 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 706 vlGYLGSLALGSFTV------AFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRG--KAMVVVEVFSILASSAA 777
Cdd:cd15447   162 --SMLISLTYNVLLIilctlyAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSdyRVQTTTMCISVSLSGSV 239
                         250
                  ....*....|....
gi 1720414110 778 LLGFIFVPKCYVIL 791
Cdd:cd15447   240 VLGCLFAPKLHIIL 253
7tmC_TAS1R1 cd15289
type 1 taste receptor subtype 1, member of the class C of seven-transmembrane G ...
541-791 3.82e-34

type 1 taste receptor subtype 1, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R1, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320416  Cd Length: 253  Bit Score: 131.39  E-value: 3.82e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 541 PLGMALGCMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVfCFLCSLL-FIGHPNQATCILQQTTFGVFFT 619
Cdd:cd15289     1 PVSWALLTALTLLLLLLAGTALLFALNLTTPVVKSAGGRTCFLMLGSLA-AASCSLYcHFGEPTWLACLLKQPLFSLSFT 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 620 VAISTVLAKTITVVMAFKLTAPGRRVRGMLVAG-APNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEHGKTILICNKG 698
Cdd:cd15289    80 VCLSCIAVRSFQIVCIFKLASKLPRFYETWAKNhGPELFILISSAVQLLISLLWLVLNPPVPTKDYDRYPDLIVLECSQT 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 699 SVIAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAAL 778
Cdd:cd15289   160 LSVGSFLELLYNCLLSISCFVFSYMGKDLPANYNEAKCITFSLLIYFISWISFFTTYSIYRGKYLMAINVLAILSSLLGI 239
                         250
                  ....*....|...
gi 1720414110 779 LGFIFVPKCYVIL 791
Cdd:cd15289   240 FGGYFLPKVYIIL 252
7tmC_mGluRs_group2_3 cd15934
metabotropic glutamate receptors in group 2 and 3, member of the class C family of ...
548-791 2.20e-33

metabotropic glutamate receptors in group 2 and 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. The mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group I mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to (Gi/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320600  Cd Length: 252  Bit Score: 129.27  E-value: 2.20e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 548 CMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLA 627
Cdd:cd15934     8 VFALLGILATLFVIVVFIRYNDTPVVKASGRELSYVLLTGILLCYLMTFVLLAKPSVITCALRRLGLGLGFSICYAALLT 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 628 KTITVVMAFKltaPGRRVRGMLVAGAPNLAIPICTLI---QIVLCGIWLVTSPPFIGRDTkSEHGKTILICNkGSVIAFH 704
Cdd:cd15934    88 KTNRISRIFN---SGKRSAKRPRFISPKSQLVICLGLisvQLIGVLVWLVVEPPGTRIDY-PRRDQVVLKCK-ISDSSLL 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 705 FVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEV--FSILASSAALLGFI 782
Cdd:cd15934   163 ISLVYNMLLIILCTVYAFKTRKIPENFNEAKFIGFTMYTTCIIWLAFVPIYFGTSNDFKIQTTTlcVSISLSASVALGCL 242

                  ....*....
gi 1720414110 783 FVPKCYVIL 791
Cdd:cd15934   243 FAPKVYIIL 251
7tmC_mGluR_group2 cd15284
metabotropic glutamate receptors in group 2, member of the class C family of ...
557-791 6.52e-32

metabotropic glutamate receptors in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320411  Cd Length: 254  Bit Score: 124.96  E-value: 6.52e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 557 TLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLAKTITVVMAF 636
Cdd:cd15284    17 TLFVIGVFIKHNNTPLVKASGRELCYILLFGVFLCYCMTFIFIAKPSPAICTLRRLGLGTSFAVCYSALLTKTNRIARIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 637 KLTAPG-RRVRGMlvagAPNLAIPIC---TLIQIVLCGIWLVTSPPFIGRDTKSEHGKT-ILICNKGSViAFHFVLGYLG 711
Cdd:cd15284    97 SGVKDGaQRPRFI----SPSSQVFIClalISVQLLVVSVWLLVEAPGTRRYTLPEKRETvILKCNVRDS-SMLISLTYDV 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 712 SLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVF--SILASSAALLGFIFVPKCYV 789
Cdd:cd15284   172 VLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMciSVSLSGFVVLGCLFAPKVHI 251

                  ..
gi 1720414110 790 IL 791
Cdd:cd15284   252 IL 253
7tmC_TAS1R cd15046
type 1 taste receptors, member of the class C of seven-transmembrane G protein-coupled ...
541-791 2.22e-31

type 1 taste receptors, member of the class C of seven-transmembrane G protein-coupled receptors; This subfamily represents the type I taste receptors (TAS1Rs) that belongs to the class C family of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320174 [Multi-domain]  Cd Length: 253  Bit Score: 123.40  E-value: 2.22e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 541 PLGMALGCMALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTV 620
Cdd:cd15046     1 APTVAVLLLAALGLLSTLAILVIFWRNFNTPVVRSAGGPMCFLMLTLLLVAYMSVPVYFGPPKVSTCLLRQALFPLCFTV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 621 AISTVLAKTITVVMAFKLTA--PGRRVRGMLVAGaPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEHGKTILICNKG 698
Cdd:cd15046    81 CLACIAVRSFQIVCIFKMASrfPRAYSYWVKYHG-PYVSIAFITVLKMVIVVIGMLATPPSPTTDTDPDPKITIVSCNPN 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 699 SVIAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAAL 778
Cdd:cd15046   160 YRNSSLFNTSLDLLLSVVCFSFSYMGKDLPTNYNEAKFITFSLTFYFTSWISFCTFMLAYSGVLVTIVDLLATLLSLLAF 239
                         250
                  ....*....|...
gi 1720414110 779 LGFIFVPKCYVIL 791
Cdd:cd15046   240 SLGYFLPKCYIIL 252
7tmC_mGluR_group3 cd15286
metabotropic glutamate receptors in group 3, member of the class C family of ...
541-801 1.16e-30

metabotropic glutamate receptors in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320413  Cd Length: 271  Bit Score: 121.83  E-value: 1.16e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 541 PLGMA-LGCMAlcfsalTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFT 619
Cdd:cd15286     6 PVALAvLGIIA------TLFVLVTFVRYNDTPIVRASGRELSYVLLTGIFLCYAITFLMVAEPGVGVCSLRRLFLGLGMS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 620 VAISTVLAKTITVVMAFK-----LTAPgrrvrgMLVAGAPNLAIPIC-TLIQIVLCGIWLVTSPPFI------GRDTKSE 687
Cdd:cd15286    80 LSYAALLTKTNRIYRIFEqgkksVTPP------RFISPTSQLVITFSlISVQLLGVLAWFAVDPPHAlidyeeGRTPDPE 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 688 HGKTILICN--KGSVIAfhfVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVV 765
Cdd:cd15286   154 QARGVLRCDmsDLSLIC---CLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKL 230
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1720414110 766 VEVFSILASSAAL-----LGFIFVPKCYVILVKSDSNFREK 801
Cdd:cd15286   231 YIQTATLTVSMSLsasvsLGMLYMPKVYVILFHPEQNVQKR 271
7tmC_mGluR4 cd15452
metabotropic glutamate receptor 4 in group 3, member of the class C family of ...
557-797 3.30e-30

metabotropic glutamate receptor 4 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320568 [Multi-domain]  Cd Length: 327  Bit Score: 122.01  E-value: 3.30e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 557 TLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLAKTITVVMAF 636
Cdd:cd15452    17 TLFVVVTFVRYNDTPIVKASGRELSYVLLTGIFLCYATTFLMIAEPDLGTCSLRRIFLGLGMSISYAALLTKTNRIYRIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 637 ---KLTAPGRRvrgmLVAGAPNLAIPIcTLIQIVLCG--IWLVTSP--PFIG----RDTKSEHGKTILICNKgSVIAFHF 705
Cdd:cd15452    97 eqgKRSVSAPR----FISPASQLVITF-SLISLQLLGvcVWFLVDPshSVVDyedqRTPDPQFARGVLKCDI-SDLSLIC 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 706 VLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKA-----MVVVEVFSILASSAALLG 780
Cdd:cd15452   171 LLGYSMLLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTSQSAekmyiQTTTLTISVSLSASVSLG 250
                         250
                  ....*....|....*..
gi 1720414110 781 FIFVPKCYVILVKSDSN 797
Cdd:cd15452   251 MLYMPKVYVILFHPEQN 267
7tmC_mGluR3 cd15448
metabotropic glutamate receptor 3 in group 2, member of the class C family of ...
557-791 9.87e-30

metabotropic glutamate receptor 3 in group 2, member of the class C family of seven-transmembrane G protein-coupled receptors; The metabotropic glutamate receptors (mGluRs) in group 2 include mGluR 2 and 3. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320564  Cd Length: 254  Bit Score: 118.51  E-value: 9.87e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 557 TLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLAKTITVVMAF 636
Cdd:cd15448    17 TCMVITVFIKHNNTPLVKASGRELCYILLFGVFLSYCMTFFFIAKPSPVICTLRRLGLGTSFAVCYSALLTKTNCIARIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 637 KLTAPGRRVRGMLvagAPNLAIPIC---TLIQIVLCGIWLVTSPPFIGRDTKSEHGKT-ILICN-KGSVIAFHfvLGYLG 711
Cdd:cd15448    97 DGVKNGAQRPKFI---SPSSQVFIClslILVQIVVVSVWLILEAPGTRRYTLPEKRETvILKCNvKDSSMLIS--LTYDV 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 712 SLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRG--KAMVVVEVFSILASSAALLGFIFVPKCYV 789
Cdd:cd15448   172 VLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSdyRVQTTTMCISVSLSGFVVLGCLFAPKVHI 251

                  ..
gi 1720414110 790 IL 791
Cdd:cd15448   252 IL 253
PBP1_GPCR_family_C-like cd06350
ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory ...
60-335 4.53e-28

ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate; categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (m; Ligand-binding domain of membrane-bound glutamate receptors that mediate excitatory transmission on the cellular surface through initial binding of glutamate and are categorized into ionotropic glutamate receptors (iGluRs) and metabotropic glutamate receptors (mGluRs). The metabotropic glutamate receptors (mGluR) are key receptors in the modulation of excitatory synaptic transmission in the central nervous system. The mGluRs are coupled to G proteins and are thus distinct from the iGluRs which internally contain ligand-gated ion channels. The mGluR structure is divided into three regions: the extracellular region, the seven-spanning transmembrane region and the cytoplasmic region. The extracellular region is further divided into the ligand-binding domain (LBD) and the cysteine-rich domain. The LBD has sequence similarity to the LIVBP, which is a bacterial periplasmic protein (PBP), as well as to the extracellular region of both iGluR and the gamma-aminobutyric acid (GABA)b receptor. iGluRs are divided into three main subtypes based on pharmacological profile: NMDA, AMPA, and kainate receptors. All family C GPCRs have a large extracellular N terminus that contain a domain with homology to bacterial periplasmic amino acid-binding proteins.


Pssm-ID: 380573  Cd Length: 350  Bit Score: 116.24  E-value: 4.53e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  60 DFYHFCIDFRIPARRYEVFLVMFFATDEINRNPYLLPNMSL---IF--CLIVGMCGDTLGYLEETHSPNNTWNSINYNCE 134
Cdd:cd06350    12 DDADFCCCGILNPRGVQLVEAMIYAIEEINNDSSLLPNVTLgydIRdtCSSSSVALESSLEFLLDNGIKLLANSNGQNIG 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 135 IRPIcdIELTGP-SWTTSV---KLAINSRKPKVFFGPFNSHLSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIGLV 210
Cdd:cd06350    92 PPNI--VAVIGAaSSSVSIavaNLLGLFKIPQISYASTSPELSDKIRYPYFLRTVPSDTLQAKAIADLLKHFNWNYVSTV 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 211 ISDDDQSIQFLSDLREAMQRHGICLAFVNMIPEN-MQIYMTRgkIYDKQIMTSSAKVVIIYGEMNSTLEV--SFRRwAYL 287
Cdd:cd06350   170 YSDDDYGRSGIEAFEREAKERGICIAQTIVIPENsTEDEIKR--IIDKLKSSPNAKVVVLFLTESDARELlkEAKR-RNL 246
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1720414110 288 cARRIWITTSQW---DVITNKrdfSFDFFHGTVTFAHHNGEIVIFRNFLQT 335
Cdd:cd06350   247 -TGFTWIGSDGWgdsLVILEG---YEDVLGGAIGVVPRSKEIPGFDDYLKS 293
7tmC_mGluR6 cd15453
metabotropic glutamate receptor 6 in group 3, member of the class C family of ...
557-803 1.10e-27

metabotropic glutamate receptor 6 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320569 [Multi-domain]  Cd Length: 273  Bit Score: 113.20  E-value: 1.10e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 557 TLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLAKTITVVMAF 636
Cdd:cd15453    17 TTTVVITFVRFNNTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPGAAVCAFRRLFLGLGTTLSYSALLTKTNRIYRIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 637 K-----LTAPGrrvrgmLVAGAPNLAIPIC-TLIQIVLCGIWLVTSPPFI------GRDTKSEHGKTILICNKgSVIAFH 704
Cdd:cd15453    97 EqgkrsVTPPP------FISPTSQLVITFSlTSLQVVGVIAWLGAQPPHSvidyeeQRTVDPEQARGVLKCDM-SDLSLI 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 705 FVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKA-----MVVVEVFSILASSAALL 779
Cdd:cd15453   170 GCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAekiyiQTTTLTVSLSLSASVSL 249
                         250       260
                  ....*....|....*....|....
gi 1720414110 780 GFIFVPKCYVILVKSDSNFREKYK 803
Cdd:cd15453   250 GMLYVPKTYVILFHPEQNVQKRKR 273
PBP1_mGluR cd06362
ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of ...
81-410 2.03e-27

ligand binding domain of metabotropic glutamate receptors (mGluR); Ligand binding domain of the metabotropic glutamate receptors (mGluR), which are members of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses. mGluRs bind to glutamate and function as an excitatory neurotransmitter; they are involved in learning, memory, anxiety, and the perception of pain. Eight subtypes of mGluRs have been cloned so far, and are classified into three groups according to their sequence similarities, transduction mechanisms, and pharmacological profiles. Group I is composed of mGlu1R and mGlu5R that both stimulate PLC hydrolysis. Group II includes mGlu2R and mGlu3R, which inhibit adenylyl cyclase, as do mGlu4R, mGlu6R, mGlu7R, and mGlu8R, which form group III.


Pssm-ID: 380585 [Multi-domain]  Cd Length: 460  Bit Score: 116.62  E-value: 2.03e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  81 MFFATDEINRNPYLLPNMSLIFcLIVGMCGD-------TLGYLEETHSPNNTWNSINYNCEIRPICD-------IELTGP 146
Cdd:cd06362    36 MLFAIDEINSRPDLLPNITLGF-VILDDCSSdttaleqALHFIRDSLLSQESAGFCQCSDDPPNLDEsfqfydvVGVIGA 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 147 sWTTSVKLAINS-----RKPKVFFGPFNSHLSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIGLVISDDDQSIQFL 221
Cdd:cd06362   115 -ESSSVSIQVANllrlfKIPQISYASTSDELSDKERYPYFLRTVPSDSFQAKAIVDILLHFNWTYVSVVYSEGSYGEEGY 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 222 SDLREAMQRHGICLAFVNMIPENMqiymtRGKIYDKQIMT----SSAKVVIIYGEMNSTLEVsFR--RWAYLCARRIWIT 295
Cdd:cd06362   194 KAFKKLARKAGICIAESERISQDS-----DEKDYDDVIQKllqkKNARVVVLFADQEDIRGL-LRaaKRLGASGRFIWLG 267
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 296 TSQWDVITNKRDFSFDFFHGTVTFAHHNGEIVIFRNFLQTVNTSKYPLDIsqtmqeW------NYFNCSisknsnskmdh 369
Cdd:cd06362   268 SDGWGTNIDDLKGNEDVALGALTVQPYSEEVPRFDDYFKSLTPSNNTRNP------WfrefwqELFQCS----------- 330
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1720414110 370 ftFNNTLEWTALQKLNMVLSEEGYN-------LYNAVYAVAHTYHELI 410
Cdd:cd06362   331 --FRPSRENSCNDDKLLINKSEGYKqeskvsfVIDAVYAFAHALHKMH 376
7tmC_mGluR5 cd15450
metabotropic glutamate receptor 5 in group 1, member of the class C family of ...
550-791 8.01e-27

metabotropic glutamate receptor 5 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320566  Cd Length: 250  Bit Score: 110.07  E-value: 8.01e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 550 ALCFSAL----TLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTV 625
Cdd:cd15450     6 AVVFACLgllaTLFVTVIFIIYRDTPVVKSSSRELCYIILAGICLGYLCTFCLIAKPKQIYCYLQRIGIGLSPAMSYSAL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 626 LAKT--ITVVMAFKLTAPGRRVRGMLVAGAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEHgKTILICNKGSvIAF 703
Cdd:cd15450    86 VTKTnrIARILAGSKKKICTKKPRFMSACAQLVIAFILICIQLGIIVALFIMEPPDIMHDYPSIR-EVYLICNTTN-LGV 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 704 HFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKamVVVEVFSILASSAALLGFIF 783
Cdd:cd15450   164 VTPLGYNGLLILSCTFYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK--IITMCFSVSLSATVALGCMF 241

                  ....*...
gi 1720414110 784 VPKCYVIL 791
Cdd:cd15450   242 VPKVYIIL 249
7tmC_mGluR8 cd15454
metabotropic glutamate receptor 8 in group 3, member of the class C family of ...
557-804 1.15e-26

metabotropic glutamate receptor 8 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320570 [Multi-domain]  Cd Length: 311  Bit Score: 111.26  E-value: 1.15e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 557 TLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLAKTITVVMAF 636
Cdd:cd15454    17 TTFVIVTFVRYNDTPIVRASGRELSYVLLTGIFLCYAITFLMIATPDTGICSFRRVFLGLGMCFSYAALLTKTNRIHRIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 637 K-----LTAPgrrvrgMLVAGAPNLAIPIcTLIQIVLCG--IWLVTSPPFI------GRDTKSEHGKTILICNKgSVIAF 703
Cdd:cd15454    97 EqgkksVTAP------KFISPASQLVITF-SLISVQLLGvfVWFAVDPPHTivdygeQRTLDPEKARGVLKCDI-SDLSL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 704 HFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKA-----MVVVEVFSILASSAAL 778
Cdd:cd15454   169 ICSLGYSILLMVTCTVYAIKTRGVPETFNEAKPIGFTMYTTCIIWLAFIPIFFGTAQSAermyiQTTTLTISMSLSASVS 248
                         250       260
                  ....*....|....*....|....*.
gi 1720414110 779 LGFIFVPKCYVILVKSDSNFREKYKN 804
Cdd:cd15454   249 LGMLYMPKVYIIIFHPEQNVQKRKRS 274
7tmC_mGluR1 cd15449
metabotropic glutamate receptor 1 in group 1, member of the class C family of ...
539-791 8.55e-26

metabotropic glutamate receptor 1 in group 1, member of the class C family of seven-transmembrane G protein-coupled receptors; Group 1 mGluRs includes mGluR1 and mGluR5, as well as their closely related invertebrate receptors. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320565  Cd Length: 250  Bit Score: 107.02  E-value: 8.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 539 EDPLGMALGCMALCfsaLTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFF 618
Cdd:cd15449     2 ESIIAVAFSCLGIL---VTMFVTLIFVLYRDTPVVKSSSRELCYIILAGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSS 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 619 TVAISTVLAKT--ITVVMAFKLTAPGRRVRGMLVAGAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEHgKTILICN 696
Cdd:cd15449    79 AMCYSALVTKTnrIARILAGSKKKICTRKPRFMSAWAQVVIASILISVQLTLVVTLIIMEPPMPILSYPSIK-EVYLICN 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 697 KgSVIAFHFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKamVVVEVFSILASSA 776
Cdd:cd15449   158 T-SNLGVVAPLGYNGLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVPIYFGSNYK--IITTCFAVSLSVT 234
                         250
                  ....*....|....*
gi 1720414110 777 ALLGFIFVPKCYVIL 791
Cdd:cd15449   235 VALGCMFTPKMYIII 249
7tmC_mGluR7 cd15451
metabotropic glutamate receptor 7 in group 3, member of the class C family of ...
557-804 1.58e-25

metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors; The receptors in group 3 include mGluRs 4, 6, 7, and 8. They are homodimeric class C G-protein coupled receptors which are activated by glutamate, the major excitatory neurotransmitter of the CNS. mGluRs are involved in regulating neuronal excitability and synaptic transmission via intracellular activation of second messenger signaling pathways. While the ionotropic glutamate receptor subtypes (AMPA, NMDA, and kainite) mediate fast excitatory postsynaptic transmission, mGluRs are known to mediate slower excitatory postsynaptic responses and to be involved in synaptic plasticity in the mammalian brain. In addition to seven-transmembrane helices, the class C GPCRs are characterized by a large N-terminal extracellular Venus flytrap-like domain, which is composed of two adjacent lobes separated by a cleft which binds an endogenous ligand. Moreover, they exist as either homo- or heterodimers, which are essential for their function. For instance, mGluRs form homodimers via interactions between the N-terminal Venus flytrap domains and the intermolecular disulphide bonds between cysteine residues located in the cysteine-rich domain (CRD). At least eight different subtypes of metabotropic receptors (mGluR1-8) have been identified and further classified into three groups based on their sequence homology, pharmacological properties, and signaling pathways. Group 1 (mGluR1 and mGluR5) receptors are predominantly located postsynaptically on neurons and are involved in long-term synaptic plasticity in the brain, including long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the cerebellum. They are coupled to G(q/11) proteins, thereby activating phospholipase C to generate inositol-1,4,5-triphosphate (IP3) and diacyglycerol (DAG), which in turn lead to Ca2+ release and protein kinase C activation, respectively. Group 1 mGluR expression is shown to be strongly upregulated in animal models of epilepsy, brain injury, inflammatory, and neuropathic pain, as well as in patients with amyotrophic lateral sclerosis or multiple sclerosis. Group 2 (mGluR2 and mGluR3) and 3 (mGluR4, mGluR6, mGluR7, and mGluR8) receptors are predominantly localized presynaptically in the active region of neurotransmitter release. They are coupled to G(i/o) proteins, which leads to inhibition of adenylate cyclase activity and cAMP formation, and consequently to a decrease in protein kinase A (PKA) activity. Ultimately, activation of these receptors leads to inhibition of neurotransmitter release such as glutamate and GABA via inhibition of Ca2+ channels and activation of K+ channels. Furthermore, while activation of Group 1 mGluRs increases NMDA (N-methyl-D-aspartate) receptor activity and risk of neurotoxicity, Group 2 and 3 mGluRs decrease NMDA receptor activity and prevent neurotoxicity.


Pssm-ID: 320567  Cd Length: 307  Bit Score: 107.80  E-value: 1.58e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 557 TLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLAKTITVVMAF 636
Cdd:cd15451    17 TIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRIFLGLGMCISYAALLTKTNRIYRIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 637 K-----LTAPgrrvrgMLVAGAPNLAIpICTLIQIVLCG--IWLVTSPPFIGRD------TKSEHGKTILICNKgSVIAF 703
Cdd:cd15451    97 EqgkksVTAP------RLISPTSQLAI-TSSLISVQLLGvlIWFAVDPPNIIIDydeqktMNPEQARGVLKCDI-TDLQI 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 704 HFVLGYLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKA-----MVVVEVFSILASSAAL 778
Cdd:cd15451   169 ICSLGYSILLMVTCTVYAIKTRGVPENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAeklyiQTTTLTISMNLSASVA 248
                         250       260
                  ....*....|....*....|....*.
gi 1720414110 779 LGFIFVPKCYVILVKSDSNFREKYKN 804
Cdd:cd15451   249 LGMLYMPKVYIIIFHPELNVQKRKRS 274
7tmC_TAS1R2a-like cd15287
type 1 taste receptor subtype 2a and similar proteins, member of the class C of ...
550-791 7.95e-25

type 1 taste receptor subtype 2a and similar proteins, member of the class C of seven-transmembrane G protein-coupled receptors; This group includes TAS1R2a and its similar proteins found in fish. They are members of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320414  Cd Length: 252  Bit Score: 104.38  E-value: 7.95e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 550 ALCFSALTLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLAKT 629
Cdd:cd15287    10 ACVLVGLTLAVSVLFAINYNTPVVRSAGGPMCFLILGCLSLCSVSVFFYFGKPTVASCILRYFPFLLFYTVCLACFVVRS 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 630 ITVVMAFKLTAPGRRVRGMLVA-GAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEHGKTILICNkGSVIAFHFVLG 708
Cdd:cd15287    90 FQIVCIFKIAAKFPKLHSWWVKyHGQWLLIAVAFVIQALLLITGFSFSPPKPYNDTSWYPDKIILSCD-INLKATSMSLV 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 709 YLGSLALGSFTVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKAMVVVEVFSILASSAALLGFIFVPKCY 788
Cdd:cd15287   169 LLLSLCCLCFIFSYMGKDLPKNYNEAKAITFCLLLLILTWIIFATEYMLYRGKYIQLLNALAVLSSLYSFLLWYFLPKCY 248

                  ...
gi 1720414110 789 VIL 791
Cdd:cd15287   249 III 251
ANF_receptor pfam01094
Receptor family ligand binding region; This family includes extracellular ligand binding ...
77-466 9.40e-22

Receptor family ligand binding region; This family includes extracellular ligand binding domains of a wide range of receptors. This family also includes the bacterial amino acid binding proteins of known structure.


Pssm-ID: 460062 [Multi-domain]  Cd Length: 347  Bit Score: 97.46  E-value: 9.40e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  77 VFLVMFFATDEINRNPYLLPnmslifclivgmcGDTLGYLeethspnntwnsINYNCeirpiCDIELT------------ 144
Cdd:pfam01094   2 VLLAVRLAVEDINADPGLLP-------------GTKLEYI------------ILDTC-----CDPSLAlaaaldllkgev 51
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 145 ----GPSWTTSVKLAIN----SRKPKVFFGPFNSHLSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIGLVISDDDQ 216
Cdd:pfam01094  52 vaiiGPSCSSVASAVASlaneWKVPLISYGSTSPALSDLNRYPTFLRTTPSDTSQADAIVDILKHFGWKRVALIYSDDDY 131
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 217 SIQFLSDLREAMQRHGICLAFVNMIPENMQIymtrGKIYDK--QIMTSSAKVVII--YGEMNSTLEVSFRRWAYLCARRI 292
Cdd:pfam01094 132 GESGLQALEDALRERGIRVAYKAVIPPAQDD----DEIARKllKEVKSRARVIVVccSSETARRLLKAARELGMMGEGYV 207
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 293 WITTSQW-DVITNKRDFSFDFFHGTVTFAHHNGEIVIFRNFlqtvntskypldisqtmqewnyFNCSISKNSNSKmdhft 371
Cdd:pfam01094 208 WIATDGLtTSLVILNPSTLEAAGGVLGFRLHPPDSPEFSEF----------------------FWEKLSDEKELY----- 260
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 372 fnntlewTALQKLNMVLseeGYNLYNAVYAVAHTYHELILQQVEFQKMAEPkGIFTDCQQVASLLKTRVFTNpVGELVNM 451
Cdd:pfam01094 261 -------ENLGGLPVSY---GALAYDAVYLLAHALHNLLRDDKPGRACGAL-GPWNGGQKLLRYLKNVNFTG-LTGNVQF 328
                         410
                  ....*....|....*...
gi 1720414110 452 K---HRENqcADYDIFNI 466
Cdd:pfam01094 329 DengDRIN--PDYDILNL 344
PBP1_taste_receptor cd06363
ligand-binding domain of the T1R taste receptor; Ligand-binding domain of the T1R taste ...
42-341 2.61e-21

ligand-binding domain of the T1R taste receptor; Ligand-binding domain of the T1R taste receptor. The T1R is a member of the family C receptors within the G-protein coupled receptor superfamily, which also includes the metabotropic glutamate receptors, GABAb receptors, the calcium-sensing receptor (CaSR), the V2R pheromone receptors, and a small group of uncharacterized orphan receptors.


Pssm-ID: 380586 [Multi-domain]  Cd Length: 418  Bit Score: 97.38  E-value: 2.61e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  42 LHRDCGFFLFTSEEPIKedfyhfCIDFRIPARRYEVFLVMFFATDEINRNPYLLPNMSL---IF--CLIVGMCGDTLGYL 116
Cdd:cd06363    15 LHELTSTLPHRPPEPTD------CSCDRFNLHGYHLAQAMRFAVEEINNSSDLLPGVTLgyeIFdtCSDAVNFRPTLSFL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 117 eethspnntwnSINYNCEIRPICD--------IELTGPSWTTSV----KLAINSRKPKVFFGPFNSHLSDHDQFPYIYQV 184
Cdd:cd06363    89 -----------SQNGSHDIEVQCNytnyqprvVAVIGPDSSELAlttaKLLGFFLMPQISYGASSEELSNKLLYPSFLRT 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 185 ATKDTHLSHGMVSLMLHFRWTWIGLVISDDDQSIQFLSDLREAMQRHGICLAFVNMIPENMQiymTRGKIYD--KQIMTS 262
Cdd:cd06363   158 VPSDKYQVEAMVQLLQEFGWNWVAFLGSDDEYGQDGLQLFSEKAANTGICVAYQGLIPTDTD---PKPKYQDilKKINQT 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 263 SAKVVIIYgemnstlevSFRRWAYL---------CARRIWITTSQW---DVITNKRDFSfdfFHGTVT-FAHHNGEIVIF 329
Cdd:cd06363   235 KVNVVVVF---------APKQAAKAffeevirqnLTGKVWIASEAWslnDTVTSLPGIQ---SIGTVLgFAIQTGTLPGF 302
                         330
                  ....*....|..
gi 1720414110 330 RNFLQTVNTSKY 341
Cdd:cd06363   303 QEFIYAFAFSVY 314
7tmC_TAS1R2 cd15288
type 1 taste receptor subtype 2, member of the class C of seven-transmembrane G ...
557-791 2.19e-20

type 1 taste receptor subtype 2, member of the class C of seven-transmembrane G protein-coupled receptors; This group represents TAS1R2, which is a member of the type I taste receptor (TAS1R) family that belongs to the class C of G protein-coupled receptors. The functional TAS1Rs are obligatory heterodimers built from three known members, TAS1R1-3. TAS1R1 combines with TAS1R3 to form an umami taste receptor, which is responsible for the perception of savory taste, such as the food additive mono-sodium glutamate (MSG); whereas the combination of TAS1R2-TAS1R3 forms a sweet-taste receptor for sugars and D-amino acids. On the other hand, the type II taste receptors (TAS2Rs), which belong to the class A family of GPCRs, recognize bitter tasting compounds. In the case of sweet, for example, the TAS1R2-TAS1R3 heterodimer activates phospholipase C (PLC) via alpha-gustducin, a heterodimeric G protein that is involved in perception of sweet and bitter tastes. This activation leads to generation of inositol (1, 4, 5)-trisphosphate (IP3) and diacylglycerol (DAG), and consequently increases intracellular Ca2+ mobilization and activates a cation channel, TRPM5. In contrast to the TAS1R2-TAS1R3 heterodimer, TAS1R3 alone could activate adenylate cyclase leading to cAMP formation in the absence of alpha-gustducin. Each TAS1R contains a large extracellular Venus flytrap-like domain in the N-terminus, cysteine-rich domain (CRD) and seven-transmembrane (7TM) domain, which are characteristics of the class C GPCRs. The Venus flytrap-like domain shares strong sequence homology to bacterial periplasmic binding proteins and possess the orthosteric amino acid and calcium binding sites for members of the class C, including CaSR, GABA-B1, GPRC6A, mGlu, and TAS1R receptors.


Pssm-ID: 320415  Cd Length: 254  Bit Score: 91.39  E-value: 2.19e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 557 TLLVFFTFVKYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGHPNQATCILQQTTFGVFFTVAISTVLAKTITVVMAF 636
Cdd:cd15288    17 TLAILVIFGRHFQTPVVRSAGGRMCFLMLAPLLVAYVNVPVYVGIPTVFTCLCRQTLFPLCFTVCISCIAVRSFQIVCIF 96
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 637 KLTAPGRRVRGMLVA-GAPNLAIPICTLIQIVLCGIWLVTSPPFIGRDTKSEHGKT-ILICNKGSVIAFHFVLGYLGSLA 714
Cdd:cd15288    97 KMARRLPRAYSYWVKyNGPYVFVALITLLKVVIVVINVLAHPTAPTTRADPDDPQVmILQCNPNYRLALLFNTSLDLLLS 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 715 LGSFTVAFLARNLPDRFNEAKFLTFSMLMF--CSVWI-TFLPVYHStrgkamVVVEVFSILASSAALLGF---IFVPKCY 788
Cdd:cd15288   177 VLGFCFAYMGKELPTNYNEAKFITLCMTFYfaSSVFLcTFMSVYEG------VLVTIFDALVTVINLLGIslgYFGPKCY 250

                  ...
gi 1720414110 789 VIL 791
Cdd:cd15288   251 MIL 253
PBP1_GPC6A-like cd06361
ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a ...
65-335 7.02e-18

ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor; This family includes the ligand-binding domain of the promiscuous L-alpha-amino acid receptor GPRC6A which is a broad-spectrum amino acid-sensing receptor, and its fish homolog, the 5.24 chemoreceptor. GPRC6A is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into cellular responses.


Pssm-ID: 380584 [Multi-domain]  Cd Length: 401  Bit Score: 86.66  E-value: 7.02e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  65 CIDFRIparryEVF---LVMFFATDEINRNPyLLPNMSLIFcLIVGMCGDTLGYLEETH---SPNNTWNSI---NYNCEI 135
Cdd:cd06361    27 CTGFDL-----RGFlqsLAMIHAIEMINNST-LLPGIKLGY-EIYDTCSDVTKALQATLrllSKFNSSNELlecDYTDYV 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 136 RPICDIelTGPSWTtSVKLAInSRKPKVFFGPFNSH------LSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIGL 209
Cdd:cd06361   100 PPVKAV--IGASYS-EISIAV-ARLLNLQLIPQISYessapiLSDKLRFPSFLRTVPSDFHQTKAMAKLISHFGWNWVGI 175
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 210 VISDDDQSIQFLSDLREAMQRHGICLAFVNMIPE-------NMQIYMTRGKIydkqIMTSSAKVVIIYGEmNSTLEVSFR 282
Cdd:cd06361   176 IYTDDDYGRSALESFIIQAEAENVCIAFKEVLPAylsdptmNVRINDTIQTI----QSSSQVNVVVLFLK-PSLVKKLFK 250
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720414110 283 RWAYLCARRIWITTSQWDV---ITNKRD-------FSFDFfhgtvtfahHNGEIVIFRNFLQT 335
Cdd:cd06361   251 EVIERNISKIWIASDNWSTareILKMPNinkvgkiLGFTF---------KSGNISSFHNYLKN 304
7tmC_GABA-B-like cd15047
gamma-aminobutyric acid type B receptor and related proteins, member of the class C family of ...
552-786 1.14e-12

gamma-aminobutyric acid type B receptor and related proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; The type B receptor for gamma-aminobutyric acid, GABA-B, is activated by its endogenous ligand GABA, the principal inhibitory neurotransmitter. The functional GABA-B receptor is an obligatory heterodimer composed of two related subunits, GABA-B1, which is primarily involved in GABA ligand binding, and GABA-B2, which is responsible for both G-protein coupling and trafficking of the heterodimer to the plasma membrane. Activation of GABA-B couples to G(i/o)-type G proteins, which in turn modulate three major downstream effectors: adenylate cyclase, voltage-sensitive Ca2+ channels, and inwardly-rectifying K+ channels. Consequently, GABA-B receptor produces slow and sustained inhibitory responses by decreased neurotransmitter release via inhibition of Ca2+ channels and by postsynaptic hyperpolarization via the activation of K+ channels through the G-protein beta-gamma dimer. The GABA-B is expressed in both pre- and postsynaptic sites of glutamatergic and GABAergic neurons in the brain where it regulates synaptic activity. Thus, the GABA-B receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in multiple sclerosis patients. Moreover, GABA-B antagonists improves cognitive performance in mammals, while GABA-B agonists suppress cognitive behavior. In most of the class C family members, the extracellular Venus-flytrap domain in the N-terminus is connected to the seven-transmembrane (7TM) via a cysteine-rich domain (CRD). However, in the GABA-B receptor, the CRD is absent in both subunits and the Venus-flytrap ligand-binding domain is directly connected to the 7TM via a 10-15 amino acids linker, suggesting that GABA-B receptor may utilize a different activation mechanism. Also included in this group are orphan receptors, GPR156 and GPR158, which are closely related to the GABA-B receptor family.


Pssm-ID: 320175  Cd Length: 263  Bit Score: 68.74  E-value: 1.14e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 552 CFSALTLLVFFTFV-KYKDTPIVKANNRILSYILLISLVFCFLCSLLFIGH---PNQATCILQQTTFGVFFTVAISTVLA 627
Cdd:cd15047    11 GIGILLALVFLIFNiKFRKNRVIKMSSPLFNNLILLGCILCYISVILFGLDdskPSSFLCTARPWLLSIGFTLVFGALFA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 628 KTITVVMAFKLTAPGRRV----RGMLVAGapnlaipICTLIQIVLCGIWLVTSPP-------FIGRDTKSEHGKTILIC- 695
Cdd:cd15047    91 KTWRIYRIFTNKKLKRIVikdkQLLKIVG-------ILLLIDIIILILWTIVDPLkptrvlvLSEISDDVKYEYVVHCCs 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 696 NKGSVIAFHFVLGYLGS-LALGSFtVAFLARNLPD-RFNEAKFLTFSM--LMFCSVwiTFLPVYHSTRGK--AMVVVEVF 769
Cdd:cd15047   164 SSNGIIWLGILLAYKGLlLLFGCF-LAWKTRNVDIeEFNESKYIGISIynVLFLSV--IGVPLSFVLTDSpdTSYLIISA 240
                         250
                  ....*....|....*..
gi 1720414110 770 SILASSAALLGFIFVPK 786
Cdd:cd15047   241 AILFCTTATLCLLFVPK 257
PBP1_glutamate_receptors-like cd06269
ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl ...
80-269 1.05e-10

ligand-binding domain of family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as natriuretic peptide receptors (NPRs), and N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of ionotropic glutamate rece; This CD represents the ligand-binding domain of the family C G-protein couples receptors (GPCRs), membrane bound guanylyl cyclases such as the family of natriuretic peptide receptors (NPRs), and the N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the ionotropic glutamate receptors, all of which are structurally similar and related to the periplasmic-binding fold type 1 family. The family C GPCRs consists of metabotropic glutamate receptor (mGluR), a calcium-sensing receptor (CaSR), gamma-aminobutyric acid receptor (GABAbR), the promiscuous L-alpha-amino acid receptor GPR6A, families of taste and pheromone receptors, and orphan receptors. Truncated splicing variants of the orphan receptors are not included in this CD. The family C GPCRs are activated by endogenous agonists such as amino acids, ions, and sugar based molecules. Their amino terminal ligand-binding region is homologous to the bacterial leucine-isoleucine-valine binding protein (LIVBP) and a leucine binding protein (LBP). The ionotropic glutamate receptors (iGluRs) have an integral ion channel and are subdivided into three major groups based on their pharmacology and structural similarities: NMDA receptors, AMPA receptors, and kainate receptors. The family of membrane bound guanylyl cyclases is further divided into three subfamilies: the ANP receptor (GC-A)/C-type natriuretic peptide receptor (GC-B), the heat-stable enterotoxin receptor (GC-C)/sensory organ specific membrane GCs such as retinal receptors (GC-E, GC-F), and olfactory receptors (GC-D and GC-G).


Pssm-ID: 380493 [Multi-domain]  Cd Length: 332  Bit Score: 63.98  E-value: 1.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  80 VMFFATDEINRNPYLLPNMslifclivgmcgdTLGYLEETHSPNNTwNSINYNCEI---RPICDIELTGPSWTTSV--KL 154
Cdd:cd06269    21 AFELALSDVNSRPDLLPKT-------------TLGLAIRDSECNPT-QALLSACDLlaaAKVVAILGPGCSASAAPvaNL 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 155 AINSRKPKVFFGPFNSHLSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIGLVISDDDQSIQFLSDLREAMQRHGIC 234
Cdd:cd06269    87 ARHWDIPVLSYGATAPGLSDKSRYAYFLRTVPPDSKQADAMLALVRRLGWNKVVLIYSDDEYGEFGLEGLEELFQEKGGL 166
                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1720414110 235 LAFVNMIPENMQIYMTRgkiYDKQIMTSSAKVVII 269
Cdd:cd06269   167 ITSRQSFDENKDDDLTK---LLRNLRDTEARVIIL 198
PBP1_mGluR_groupI cd06374
ligand binding domain of the group I metabotropic glutamate receptor; Ligand binding domain of ...
80-482 2.56e-09

ligand binding domain of the group I metabotropic glutamate receptor; Ligand binding domain of the group I metabotropic glutamate receptor, a family containing mGlu1R and mGlu5R, all of which stimulate phospholipase C (PLC) hydrolysis. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes.


Pssm-ID: 380597 [Multi-domain]  Cd Length: 474  Bit Score: 60.43  E-value: 2.56e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  80 VMFFATDEINRNPYLLPNMSLiFCLIVGMC-------GDTLGYLEETHSPNNTWNSINYNCEIRPICDIE-------LTG 145
Cdd:cd06374    46 AMFRTLDKINKDPNLLPNITL-GIEIRDSCwyspvalEQSIEFIRDSVASVEDEKDTQNTPDPTPLSPPEnrkpivgVIG 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 146 P---SWTTSVK-----LAInsrkPKVFFGPFNSHLSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIGLVISDDDQS 217
Cdd:cd06374   125 PgssSVTIQVQnllqlFHI----PQIGYSATSIDLSDKSLYKYFLRVVPSDYLQARAMLDIVKRYNWTYVSTVHTEGNYG 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 218 IQFLSDLREAMQRHGICLAFVNMIPENmqiymTRGKIYD---KQIMT--SSAKVVIIYGEMNSTlevsfrRWAYLCARRI 292
Cdd:cd06374   201 ESGIEAFKELAAEEGICIAHSDKIYSN-----AGEEEFDrllRKLMNtpNKARVVVCFCEGETV------RGLLKAMRRL 269
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 293 -------WITTSQW----DVItnkRDFSfDFFHGTVTFAHHNGEIVIFRNFLQTVNTSKYplDISQTMQE-WNY-FNCSI 359
Cdd:cd06374   270 natghflLIGSDGWadrkDVV---EGYE-DEAAGGITIKIHSPEVESFDEYYFNLKPETN--SRNPWFREfWQHrFDCRL 343
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 360 SKNSNSKMDHF---TFNNTLEWTALQ--KLNMVLseegynlyNAVYAVAHTYHELilqqvefQKMAEPKGIFTDCQQ--- 431
Cdd:cd06374   344 PGHPDENPYFKkccTGEESLLGNYVQdsKLGFVI--------NAIYAMAHALHRM-------QEDLCGGYSVGLCPAmlp 408
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1720414110 432 ------VASLLKTRvFTNPVGELVNMKHRENQCADYDIFNIWNFPQGLGLRVKIGSY 482
Cdd:cd06374   409 ingsllLDYLLNVS-FVGVSGDTIMFDENGDPPGRYDIMNFQKTGEGSYDYVQVGSW 464
PBP1_mGluR_groupII cd06375
ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain ...
81-483 1.47e-07

ligand binding domain of the group II metabotropic glutamate receptor; Ligand binding domain of the group II metabotropic glutamate receptor, a family that contains mGlu2R and mGlu3R, all of which inhibit adenylyl cyclase. The metabotropic glutamate receptor is a member of the family C of G-protein-coupled receptors that transduce extracellular signals into G-protein activation and ultimately into intracellular responses. The mGluRs are classified into three groups which comprise eight subtypes


Pssm-ID: 380598 [Multi-domain]  Cd Length: 462  Bit Score: 54.83  E-value: 1.47e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  81 MFFATDEINRNPYLLPNMSLiFCLIVGMCG-DTLGY---LEETHSPNNTWNSINYNC---------EIRPICDIELTGPS 147
Cdd:cd06375    40 MLFAIDRINRDPHLLPGVRL-GVHILDTCSrDTYALeqsLEFVRASLTKVDDSEYMCpddgsyaiqEDSPLPIAGVIGGS 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 148 WTtSVKLAINS-----RKPKVFFGPFNSHLSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIGLVISDDD---QSIQ 219
Cdd:cd06375   119 YS-SVSIQVANllrlfQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDygeTGIE 197
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 220 FLSdlREAMQRHgICLAFVNMIPENMQiymtrGKIYDKQI----MTSSAKVVIIYGEMNSTLEVsFRRWAYLCARRIWIT 295
Cdd:cd06375   198 AFE--QEARLRN-ICIATAEKVGRSAD-----RKSFDGVIrellQKPNARVVVLFTRSDDAREL-LAAAKRLNASFTWVA 268
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 296 TSQWDVITNKRDFSFDFFHGTVTFAHHNGEIVIFRNFLQTV---NTSKYPldisqtmqeW------NYFNCSISKNSNSK 366
Cdd:cd06375   269 SDGWGAQESIVKGSEDVAEGAITLELASHPIPDFDRYFQSLtpyNNHRNP---------WfrdfweQKFQCSLQNKSQAA 339
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 367 MDhftfnnTLEWTALQKLNMVLSEEGYNLYNAVYAVAHTYHELILQQVEFQKMAepkgiftdCQQVASLLKTRVFTN--- 443
Cdd:cd06375   340 SV------SDKHLSIDSSNYEQESKIMFVVNAVYAMAHALHNMQRTLCPNTTRL--------CDAMRSLDGKKLYKDyll 405
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1720414110 444 -----------PVGELVNMKHRENQCADYDIFNIWNFPQGLGLR-VKIGSYY 483
Cdd:cd06375   406 nvsftapfppaDAGSEVKFDAFGDGLGRYNIFNYQRAGGSYGYRyKGVGKWA 457
7tmC_GPR158-like cd15293
orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G ...
541-791 1.63e-07

orphan GPR158 and similar proteins, member of the class C family of seven-transmembrane G protein-coupled receptors; This group includes orphan receptors GPR158, GPR158-like (also called GPR179) and similar proteins. These orphan receptors are closely related to the type B receptor for gamma-aminobutyric acid (GABA-B), which is activated by its endogenous ligand GABA, the principal inhibitory neurotransmitter. The functional GABA-B receptor is an obligatory heterodimer composed of two related subunits, GABA-B1, which is primarily involved in GABA ligand binding, and GABA-B2, which is responsible for both G-protein coupling and trafficking of the heterodimer to the plasma membrane. Activation of GABA-B couples to G(i/o)-type G proteins, which in turn modulate three major downstream effectors: adenylate cyclase, voltage-sensitive Ca2+ channels, and inwardly-rectifying K+ channels. Consequently, GABA-B receptor produces slow and sustained inhibitory responses by decreased neurotransmitter release via inhibition of Ca2+ channels and by postsynaptic hyperpolarization via the activation of K+ channels through the G-protein beta-gamma dimer. The GABA-B is expressed in both pre- and postsynaptic sites of glutamatergic and GABAergic neurons in the brain where it regulates synaptic activity. Thus, the GABA-B receptor agonist, baclofen, is used to treat muscle tightness and cramping caused by spasticity in multiple sclerosis patients. Moreover, GABA-B antagonists improves cognitive performance in mammals, while GABA-B agonists suppress cognitive behavior. In most of the class C family members, the extracellular Venus-flytrap domain in the N-terminus is connected to the seven-transmembrane (7TM) via a cysteine-rich domain (CRD). However, in the GABA-B receptor, the CRD is absent in both subunits and the Venus-flytrap ligand-binding domain is directly connected to the 7TM via a 10-15 amino acids linker, suggesting that GABA-B receptor may utilize a different activation mechanism.


Pssm-ID: 320420  Cd Length: 252  Bit Score: 53.37  E-value: 1.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 541 PLGMALGCMALCFsaltLLVFFTFvKYKDTPIVKANNRILSYILLISLVFcfLCSLLFIGH--PNQATCILQQTTFGVFF 618
Cdd:cd15293     6 VLAVQAICILLCL----VLALVVF-RFRKVKVIKAASPILLELILFGALL--LYFPVFILYfePSVFRCILRPWFRHLGF 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 619 TVAISTVLAKTITVVMAFKLTAPGRRV---RGMLVAGAPNLAIPICTLIqivlcgIWLVTSPPFIGR-DTKSEHGKTILI 694
Cdd:cd15293    79 AIVYGALILKTYRILVVFRSRSARRVHltdRDLLKRLGLIVLVVLGYLA------AWTAVNPPNVEVgLTLTSSGLKFNV 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 695 CNkgSVIAFH-FVLGYLGSLALGSFtVAFLARNLPDRFNEAKFLTFSMLMFCSVWITFLPVYHSTRGKA----MVVVEVF 769
Cdd:cd15293   153 CS--LDWWDYvMAIAELLFLLWGVY-LCYAVRKAPSAFNESRYISLAIYNELLLSVIFNIIRFFLLPSLhpdlLFLLFFL 229
                         250       260
                  ....*....|....*....|..
gi 1720414110 770 SILASSAALLGFIFVPKCYVIL 791
Cdd:cd15293   230 HTQLTVTVTLLLIFGPKFYLVL 251
PBP1_GABAb_receptor cd06366
ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for ...
155-233 3.27e-05

ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA); Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.


Pssm-ID: 380589 [Multi-domain]  Cd Length: 404  Bit Score: 47.24  E-value: 3.27e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 155 AINSRKPKV-FFGPFNSH-------------------------LSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIG 208
Cdd:cd06366    64 LLYTPPPKVmLLGPGCSSvtepvaeaskywnlvqlsyaatspaLSDRKRYPYFFRTVPSDTAFNPARIALLKHFGWKRVA 143
                          90       100
                  ....*....|....*....|....*
gi 1720414110 209 LVISDDDQSIQFLSDLREAMQRHGI 233
Cdd:cd06366   144 TIYQNDEVFSSTAEDLEELLEEANI 168
PBP1_SAP_GC-like cd06370
Ligand-binding domain of membrane bound guanylyl cyclases; Ligand-binding domain of membrane ...
81-403 1.56e-04

Ligand-binding domain of membrane bound guanylyl cyclases; Ligand-binding domain of membrane bound guanylyl cyclases (GCs), which are known to be activated by sperm-activating peptides (SAPs), such as speract or resact. These ligand peptides are released by a range of invertebrates to stimulate the metabolism and motility of spermatozoa and are also potent chemoattractants. These GCs contain a single transmembrane segment, an extracellular ligand binding domain, and intracellular protein kinase-like and cyclase catalytic domains. GCs of insect and nematodes, which exhibit high sequence similarity to the speract receptor are also included in this model.


Pssm-ID: 380593 [Multi-domain]  Cd Length: 400  Bit Score: 44.93  E-value: 1.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110  81 MFFATDEINRNPYLLPN--MSLIFclivgmcgdtlgyleethspNNTWnsinynceirpiCDIEltgpswtTSVKLAINS 158
Cdd:cd06370    26 ITLAVDDVNNDPNLLPGhtLSFVW--------------------NDTR------------CDEL-------LSIRAMTEL 66
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 159 RKPKV--FFGP-------------FN----------SHLSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIGLVISD 213
Cdd:cd06370    67 WKRGVsaFIGPgctcatearlaaaFNlpmisykcadPEVSDKSLYPTFARTIPPDSQISKSVIALLKHFNWNKVSIVYEN 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 214 DDQSIQFLSDLREAMQRHGICLAFVNMIPENMQIYMTRGKIYDkQIMTSS---AKVVIIYGEMNstlevSFRRWAYLCAR 290
Cdd:cd06370   147 ETKWSKIADTIKELLELNNIEINHEEYFPDPYPYTTSHGNPFD-KIVEETkekTRIYVFLGDYS-----LLREFMYYAED 220
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 291 R----------IWITTSQWDVITNKRDFSFDFFHGTVTFAHHNGEivIFRNFLQ-TVNTSKYPldisqtmqEWNYFNCSI 359
Cdd:cd06370   221 LglldngdyvvIGVELDQYDVDDPAKYPNFLSGDYTKNDTKEALE--AFRSVLIvTPSPPTNP--------EYEKFTKKV 290
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1720414110 360 sKNSNSKmdhFTFNntLEWTALQKLNMVLSEEGYNLYNAV--YAVA 403
Cdd:cd06370   291 -KEYNKL---PPFN--FPNPEGIEKTKEVPIYAAYLYDAVmlYARA 330
PBP1_GABAb_receptor_plant cd19990
periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close ...
172-332 1.29e-03

periplasmic ligand-binding domain of Arabidopsis thaliana glutamate receptors and its close homologs in other plants; This group includes the ligand-binding domain of Arabidopsis thaliana glutamate receptors, which have sequence similarity with animal ionotropic glutamate receptor and its close homologs in other plants. The ligand-binding domain of GABAb receptors are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA). GABA is the major inhibitory neurotransmitter in the mammalian CNS and, like glutamate and other transmitters, acts via both ligand gated ion channels (GABAa receptors) and G-protein coupled receptors (GABAb receptor or GABAbR). GABAa receptors are members of the ionotropic receptor superfamily which includes alpha-adrenergic and glycine receptors. The GABAb receptor is a member of a receptor superfamily which includes the mGlu receptors. The GABAb receptor is coupled to G alpha-i proteins, and activation causes a decrease in calcium, an increase in potassium membrane conductance, and inhibition of cAMP formation. The response is thus inhibitory and leads to hyperpolarization and decreased neurotransmitter release, for example.


Pssm-ID: 380645 [Multi-domain]  Cd Length: 373  Bit Score: 41.83  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 172 LSDHDQFPYIYQVATKDTHLSHGMVSLMLHFRWTWIGLVISDDDQSIQFLSDLREAMQRHGI----CLAFVNMIPENMqi 247
Cdd:cd19990   100 TLSSLRWPFFIRMTHNDSSQMKAIAAIVQSYGWRRVVLIYEDDDYGSGIIPYLSDALQEVGSrieyRVALPPSSPEDS-- 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720414110 248 ymtrgkIYDK--QIMTSSAKVVIIYGEMNSTLEVsfrrwaYLCARRI--------WITTsqwDVITNKRDfSFDF----- 312
Cdd:cd19990   178 ------IEEEliKLKSMQSRVFVVHMSSLLASRL------FQEAKKLgmmekgyvWIVT---DGITNLLD-SLDSstiss 241
                         170       180
                  ....*....|....*....|
gi 1720414110 313 FHGTVTFAHHNGEIVIFRNF 332
Cdd:cd19990   242 MQGVIGIKTYIPESSEFQDF 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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