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Conserved domains on  [gi|1720416754|ref|XP_030110957|]
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probable 28S rRNA (cytosine-C(5))-methyltransferase isoform X1 [Mus musculus]

Protein Classification

NOL1/NOP2/SUN domain family protein( domain architecture ID 1003105)

NOL1/NOP2/SUN domain (NSUN) family protein such as mammalian nucleolar protein NOP2 which is required for nucleolar maturation and ribosome biogenesis

Gene Ontology:  GO:0003723|GO:0000027|GO:0008173|GO:0001510

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
nop2p super family cl33194
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 297-571 4.32e-117

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


The actual alignment was detected with superfamily member TIGR00446:

Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 354.47  E-value: 4.32e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 297 LRTNTLKTRRRDLAQALINRGVNLDPLGKWSKsgLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDM 376
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYF--FEVKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 377 CCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISK 456
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLLKFDAILLDAPCSGEGVIRK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 457 DPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTgldFGQEG 535
Cdd:TIGR00446 159 DPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEENEEVIDYILRKRpDVVEEII---KGDEF 231

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1720416754 536 FTRFQARrfhPTLRSTRRFYPHTHNMDGFFIAKFKK 571
Cdd:TIGR00446 232 FGINIGK---GEVKGALRVFPQNYDCEGFFVAKLRK 264
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 577-794 6.54e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 6.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754  577 PQPHA-----GNSAAATPTEPDLKDQVTPKSENGSQPTKKARGA-VKAKQQLLRQPHSKKPFQKLNGIAKGPGLSTEP-S 649
Cdd:PHA03247  2631 PSPAAnepdpHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAqASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPeP 2710

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754  650 VPDAQVSTRP----SQSAGNADVNSKRKRSEKLKQRGPKwKPSKEAAVPKPSAPSrvedsrTPPVPTPSEIRAAPRPKDC 725
Cdd:PHA03247  2711 APHALVSATPlppgPAAARQASPALPAAPAPPAVPAGPA-TPGGPARPARPPTTA------GPPAPAPPAAPAAGPPRRL 2783

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720416754  726 AP----SLGEAKKKQKGKQQLAQQPANGAAPLKEDAVSKGPSAPFVSPHSSTRPPPAKrrksmTKGNSQPLLS 794
Cdd:PHA03247  2784 TRpavaSLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP-----PPGPPPPSLP 2851
 
Name Accession Description Interval E-value
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 297-571 4.32e-117

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 354.47  E-value: 4.32e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 297 LRTNTLKTRRRDLAQALINRGVNLDPLGKWSKsgLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDM 376
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYF--FEVKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 377 CCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISK 456
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLLKFDAILLDAPCSGEGVIRK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 457 DPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTgldFGQEG 535
Cdd:TIGR00446 159 DPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEENEEVIDYILRKRpDVVEEII---KGDEF 231

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1720416754 536 FTRFQARrfhPTLRSTRRFYPHTHNMDGFFIAKFKK 571
Cdd:TIGR00446 232 FGINIGK---GEVKGALRVFPQNYDCEGFFVAKLRK 264
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 222-571 6.73e-106

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 331.97  E-value: 6.73e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 222 QRVHKRIQDIV-GVLRDFGAQREEgrsrAEYLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTN 300
Cdd:COG0144   107 EAVGPGAAGLVnAVLRRVLREREA----LLAAADPVERLAVRYSHPEWLVERLRAAYGPEEAEALLAALNEPPPLDLRVN 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 301 TLKTRRRDLAQALINRGVNLDPlGKWSKSGLVVyDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAP 380
Cdd:COG0144   183 TLKASREELLARLAEEGIEAEP-TPLSPDGLRL-EGPGPVTALPGFREGLFSVQDEASQLVALLLDPKPGERVLDLCAAP 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 381 GGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGG-FDRVLLDAPCSGTGVISKDPA 459
Cdd:COG0144   261 GGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLARLGLSNVEVVVADARELLEWLPGkFDRVLLDAPCSGTGTLRRHPD 340

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 460 VKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTGLDFGQEGFTR 538
Cdd:COG0144   341 IKWRRTPEDIAELAALQRELLDAAARLL----KPGGRLVYSTCSLLPEENEEVVEAFLARHpDFELVPLAELLPGLALTD 416

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1720416754 539 fqarrfhptlRSTRRFYPHTHNMDGFFIAKFKK 571
Cdd:COG0144   417 ----------GGYLRLLPHRHGTDGFFIARLRK 439
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 362-570 7.13e-103

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 315.13  E-value: 7.13e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 362 VMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGG--F 439
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNGDGRQPDQWLGGvlF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 440 DRVLLDAPCSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKK 519
Cdd:pfam01189  81 DRILLDAPCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLL----KPGGVLVYSTCSVLPEENEAVIEYFLQK 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720416754 520 R-NVRLVPT------GLDFGQEgftrfqarrfhptlrSTRRFYPHTHNMDGFFIAKFK 570
Cdd:pfam01189 157 HpDVELVPTplfepvGLAIGEQ---------------PTLRLLPHTHNGDGFFIAKLR 199
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
223-571 5.96e-84

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 274.36  E-value: 5.96e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 223 RVHKRIQDIV-GVLRDFgaQREEGRSRAEyLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTNT 301
Cdd:PRK14902  109 RGHKGIAKFVnGVLRNI--LREGLPDIDE-IKDPVKRLSIKYSHPVWLVKRWIDQYGEEKAEKILESLNEPPKASIRVNT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 302 LKTRRRDLAQALINRGVNLDPlGKWSKSGLVVydSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPG 381
Cdd:PRK14902  186 LKISVEELIEKLEEEGYEVEE-SLLSPEALVI--EKGNIAGTDLFKDGLITIQDESSMLVAPALDPKGGDTVLDACAAPG 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 382 GKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGG-FDRVLLDAPCSGTGVISKDPAV 460
Cdd:PRK14902  263 GKTTHIAELLKNTGKVVALDIHEHKLKLIEENAKRLGLTNIETKALDARKVHEKFAEkFDKILVDAPCSGLGVIRRKPDI 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 461 KTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKrnvrlvptGLDFGQEGFTRFQ 540
Cdd:PRK14902  343 KYNKTKEDIESLQEIQLEILESVAQYL----KKGGILVYSTCTIEKEENEEVIEAFLEE--------HPEFELVPLQHEK 410

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1720416754 541 A-RRFHPTLRSTRRFYPHTHNMDGFFIAKFKK 571
Cdd:PRK14902  411 PdELVYEVKDGYLQILPNDYGTDGFFIAKLRK 442
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 372-500 8.79e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.11  E-value: 8.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 372 RILDMCCAPGGKTSYIAQLMKntGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKV-VGGFDRVLLDAPCsg 450
Cdd:cd02440     1 RVLDLGCGTGALALALASGPG--ARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEaDESFDVIISDPPL-- 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720416754 451 tgviskdpavktnkdekdiqrcaHLQKELLLSAIDSVNAASKTGGYLVYC 500
Cdd:cd02440    77 -----------------------HHLVEDLARFLEEARRLLKPGGVLVLT 103
PHA03247 PHA03247
large tegument protein UL36; Provisional
 577-794 6.54e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 6.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754  577 PQPHA-----GNSAAATPTEPDLKDQVTPKSENGSQPTKKARGA-VKAKQQLLRQPHSKKPFQKLNGIAKGPGLSTEP-S 649
Cdd:PHA03247  2631 PSPAAnepdpHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAqASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPeP 2710

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754  650 VPDAQVSTRP----SQSAGNADVNSKRKRSEKLKQRGPKwKPSKEAAVPKPSAPSrvedsrTPPVPTPSEIRAAPRPKDC 725
Cdd:PHA03247  2711 APHALVSATPlppgPAAARQASPALPAAPAPPAVPAGPA-TPGGPARPARPPTTA------GPPAPAPPAAPAAGPPRRL 2783

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720416754  726 AP----SLGEAKKKQKGKQQLAQQPANGAAPLKEDAVSKGPSAPFVSPHSSTRPPPAKrrksmTKGNSQPLLS 794
Cdd:PHA03247  2784 TRpavaSLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP-----PPGPPPPSLP 2851
P120R pfam08062
P120R (NUC006) repeat; This characteriztic repeat of proliferating cell nuclear antigen P120 ...
 609-630 8.43e-04

P120R (NUC006) repeat; This characteriztic repeat of proliferating cell nuclear antigen P120 is found in three copies.


Pssm-ID: 285324  Cd Length: 22  Bit Score: 37.08  E-value: 8.43e-04
                          10        20
                  ....*....|....*....|..
gi 1720416754 609 TKKARGAVKAKQQLLRQPHSKK 630
Cdd:pfam08062   1 AGKAKGAEKRKQQLLKQPHPKK 22
 
Name Accession Description Interval E-value
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 297-571 4.32e-117

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 354.47  E-value: 4.32e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 297 LRTNTLKTRRRDLAQALINRGVNLDPLGKWSKsgLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDM 376
Cdd:TIGR00446   1 IRVNTLKINVEDLLERLENRGVVLEPTCEEYF--FEVKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDM 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 377 CCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISK 456
Cdd:TIGR00446  79 AAAPGGKTTQISQLMKNKGCIVANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLLKFDAILLDAPCSGEGVIRK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 457 DPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTgldFGQEG 535
Cdd:TIGR00446 159 DPSRKRNWSEEDIKYCSLLQKELIDAAIDAL----KPGGVLVYSTCSLEVEENEEVIDYILRKRpDVVEEII---KGDEF 231

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1720416754 536 FTRFQARrfhPTLRSTRRFYPHTHNMDGFFIAKFKK 571
Cdd:TIGR00446 232 FGINIGK---GEVKGALRVFPQNYDCEGFFVAKLRK 264
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 222-571 6.73e-106

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 331.97  E-value: 6.73e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 222 QRVHKRIQDIV-GVLRDFGAQREEgrsrAEYLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTN 300
Cdd:COG0144   107 EAVGPGAAGLVnAVLRRVLREREA----LLAAADPVERLAVRYSHPEWLVERLRAAYGPEEAEALLAALNEPPPLDLRVN 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 301 TLKTRRRDLAQALINRGVNLDPlGKWSKSGLVVyDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAP 380
Cdd:COG0144   183 TLKASREELLARLAEEGIEAEP-TPLSPDGLRL-EGPGPVTALPGFREGLFSVQDEASQLVALLLDPKPGERVLDLCAAP 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 381 GGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGG-FDRVLLDAPCSGTGVISKDPA 459
Cdd:COG0144   261 GGKTLHLAELMGNKGRVVAVDISEHRLKRLRENLARLGLSNVEVVVADARELLEWLPGkFDRVLLDAPCSGTGTLRRHPD 340

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 460 VKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTGLDFGQEGFTR 538
Cdd:COG0144   341 IKWRRTPEDIAELAALQRELLDAAARLL----KPGGRLVYSTCSLLPEENEEVVEAFLARHpDFELVPLAELLPGLALTD 416

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1720416754 539 fqarrfhptlRSTRRFYPHTHNMDGFFIAKFKK 571
Cdd:COG0144   417 ----------GGYLRLLPHRHGTDGFFIARLRK 439
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 362-570 7.13e-103

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 315.13  E-value: 7.13e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 362 VMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGG--F 439
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNGDGRQPDQWLGGvlF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 440 DRVLLDAPCSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKK 519
Cdd:pfam01189  81 DRILLDAPCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLL----KPGGVLVYSTCSVLPEENEAVIEYFLQK 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1720416754 520 R-NVRLVPT------GLDFGQEgftrfqarrfhptlrSTRRFYPHTHNMDGFFIAKFK 570
Cdd:pfam01189 157 HpDVELVPTplfepvGLAIGEQ---------------PTLRLLPHTHNGDGFFIAKLR 199
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
223-571 5.96e-84

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 274.36  E-value: 5.96e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 223 RVHKRIQDIV-GVLRDFgaQREEGRSRAEyLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTNT 301
Cdd:PRK14902  109 RGHKGIAKFVnGVLRNI--LREGLPDIDE-IKDPVKRLSIKYSHPVWLVKRWIDQYGEEKAEKILESLNEPPKASIRVNT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 302 LKTRRRDLAQALINRGVNLDPlGKWSKSGLVVydSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPG 381
Cdd:PRK14902  186 LKISVEELIEKLEEEGYEVEE-SLLSPEALVI--EKGNIAGTDLFKDGLITIQDESSMLVAPALDPKGGDTVLDACAAPG 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 382 GKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGG-FDRVLLDAPCSGTGVISKDPAV 460
Cdd:PRK14902  263 GKTTHIAELLKNTGKVVALDIHEHKLKLIEENAKRLGLTNIETKALDARKVHEKFAEkFDKILVDAPCSGLGVIRRKPDI 342

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 461 KTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDYALKKrnvrlvptGLDFGQEGFTRFQ 540
Cdd:PRK14902  343 KYNKTKEDIESLQEIQLEILESVAQYL----KKGGILVYSTCTIEKEENEEVIEAFLEE--------HPEFELVPLQHEK 410

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1720416754 541 A-RRFHPTLRSTRRFYPHTHNMDGFFIAKFKK 571
Cdd:PRK14902  411 PdELVYEVKDGYLQILPNDYGTDGFFIAKLRK 442
yebU PRK11933
rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed
 284-580 3.85e-60

rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed


Pssm-ID: 183387 [Multi-domain]  Cd Length: 470  Bit Score: 210.92  E-value: 3.85e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 284 EFLEANEVPRPITLRTNTLKTRRRDLAQALINRGVNLDPLgKWSKSGLVV---YDSSVPIGATPEYLAGHYMLQGASSML 360
Cdd:PRK11933   24 DFIAACQRPLRRSIRVNTLKISVADFLQLMAPYGWTLTPI-PWCEEGFWIerdDEDALPLGNTAEHLSGLFYIQEASSML 102

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 361 PVMAL-APQEH-ERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFpkvvGG 438
Cdd:PRK11933  103 PVAALfADDNApQRVLDMAAAPGSKTTQIAALMNNQGAIVANEYSASRVKVLHANISRCGVSNVALTHFDGRVF----GA 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 439 -----FDRVLLDAPCSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDsvnaASKTGGYLVYCTCSITVEENEWVV 513
Cdd:PRK11933  179 alpetFDAILLDAPCSGEGTVRKDPDALKNWSPESNLEIAATQRELIESAFH----ALKPGGTLVYSTCTLNREENQAVC 254

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1720416754 514 DYaLKKR---NVRLVPTGLDFGQ-------EGFtrfqarrFHptlrstrrFYPHTHNMDGFFIAKFKKFSNSIPQPH 580
Cdd:PRK11933  255 LW-LKETypdAVEFEPLGDLFPGaekalteEGF-------LH--------VFPQIYDSEGFFVARLRKTASVPRLPA 315
rsmB TIGR00563
16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. ...
 225-571 6.47e-55

16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. The reading frame was originally interpreted as two reading frames, fmu and fmv. The recombinant protein from E. coli was shown to methylate only C967 of small subunit (16S) ribosomal RNA and to produce only m5C at that position. The seed alignment is built from bacterial sequences only. Eukaryotic homologs include Nop2, a protein required for processing pre-rRNA, that is likely also a rRNA methyltransferase, although the fine specificity may differ. Cutoff scores are set to avoid treating archaeal and eukaroytic homologs automatically as functionally equivalent, although they may have very similar roles. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273141 [Multi-domain]  Cd Length: 426  Bit Score: 195.47  E-value: 6.47e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 225 HKRIQDIV-GVLRDFgaQREEGRSRAEYLSrlqkdLATYYSYGDFLLSKLMELFPLSELiEFLEANEVPRPITLRTNTLK 303
Cdd:TIGR00563 103 RKGLKGLVnGVLRRF--QREQEELLAEFNA-----LDARYLHPEWLVKRLQKAYPGQWQ-SICEANNQRPPMWLRINRTK 174

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 304 TRRRDLAQALINRGVNLDPLGKWSKSglVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGK 383
Cdd:TIGR00563 175 HSRDEWLALLAEAGMKGFPHDLAPDA--VRLETPAAVHALPGFEEGWVTVQDASAQWVATWLAPQNEETILDACAAPGGK 252

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 384 TSYIAQLMKNtGVILANDANADRLKSVVGNLHRLGVTnTIISHYDGRQ----FPKVVGGFDRVLLDAPCSGTGVISKDPA 459
Cdd:TIGR00563 253 TTHILELAPQ-AQVVALDIHEHRLKRVYENLKRLGLT-IKAETKDGDGrgpsQWAENEQFDRILLDAPCSATGVIRRHPD 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 460 VKTNKDEKDIQRCAHLQKELLlsaiDSVNAASKTGGYLVYCTCSITVEENEWVVDyalkkrnvrlvptglDFGQEGFTR- 538
Cdd:TIGR00563 331 IKWLRKPRDIAELAELQSEIL----DAIWPLLKTGGTLVYATCSVLPEENSEQIK---------------AFLQEHPDFp 391

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1720416754 539 FQARRFHPTLRSTR-RFYPHTHNMDGFFIAKFKK 571
Cdd:TIGR00563 392 FEKTGTPEQVRDGGlQILPHAEEGDGFFYAKLIK 425
PRK14901 PRK14901
16S rRNA methyltransferase B; Provisional
 233-571 6.90e-55

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237856 [Multi-domain]  Cd Length: 434  Bit Score: 195.53  E-value: 6.90e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 233 GVLRDFGAQREEGRSrAEYLSRLQKDLATYYSYGDFLLSKLMELFPLSELIEFLEA-NEVPrPITLRTNTLKTRRRDLAQ 311
Cdd:PRK14901  118 GILRQYLRAREAGDP-LPLPEDPIERLAILHSFPDWLVKLWLEWLGLEEAEQLCKWfNQPP-SLDLRINPLRTSLEEVQA 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 312 ALINRGVNLDPLGKwSKSGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLM 391
Cdd:PRK14901  196 ALAEAGITATPIPG-LPQGLRLTGNPGSIRQLPGYEEGWWTVQDRSAQLVAPLLDPQPGEVILDACAAPGGKTTHIAELM 274

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 392 KNTGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQF----PKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEK 467
Cdd:PRK14901  275 GDQGEIWAVDRSASRLKKLQENAQRLGLKSIKILAADSRNLlelkPQWRGYFDRILLDAPCSGLGTLHRHPDARWRQTPE 354

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 468 DIQRCAHLQKELLLSAIDSVnaasKTGGYLVYCTCSITVEENEWVVDyalkkrnvrlvptgldfgqegftRFQARrfHPT 547
Cdd:PRK14901  355 KIQELAPLQAELLESLAPLL----KPGGTLVYATCTLHPAENEAQIE-----------------------QFLAR--HPD 405

                         330       340
                  ....*....|....*....|....*..
gi 1720416754 548 LRS---TRRFYPHTHNMDGFFIAKFKK 571
Cdd:PRK14901  406 WKLeppKQKIWPHRQDGDGFFMAVLRK 432
PRK10901 PRK10901
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
233-571 1.22e-53

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 236790 [Multi-domain]  Cd Length: 427  Bit Score: 191.94  E-value: 1.22e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 233 GVLRDFgaQREegrsRAEYLSRLQKDLATYYSYGDFLLSKLMELFPlSELIEFLEANEVPRPITLRTNTLKTRRRDLAQA 312
Cdd:PRK10901  117 AVLRRF--QRE----QEELLAELQADPVARYNHPSWLIKRLKKAYP-EQWQAILAANNQRPPMWLRVNRRHHSRDAYLAL 189

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 313 LINRGVNLDPlGKWSKSGLVVyDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLMK 392
Cdd:PRK10901  190 LAEAGIEAFP-HAVGPDAIRL-ETPVPVHQLPGFAEGWVSVQDAAAQLAATLLAPQNGERVLDACAAPGGKTAHILELAP 267

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 393 NTGVIlANDANADRLKSVVGNLHRLGVTNTII--------SHYDGRQfpkvvggFDRVLLDAPCSGTGVISKDPAVKTNK 464
Cdd:PRK10901  268 QAQVV-ALDIDAQRLERVRENLQRLGLKATVIvgdardpaQWWDGQP-------FDRILLDAPCSATGVIRRHPDIKWLR 339

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 465 DEKDIQRCAHLQKELLlsaiDSVNAASKTGGYLVYCTCSITVEENEWVVDYALKKR-NVRLVPTGLDFGqegftrfqarr 543
Cdd:PRK10901  340 RPEDIAALAALQSEIL----DALWPLLKPGGTLLYATCSILPEENEQQIKAFLARHpDAELLDTGTPQQ----------- 404

                         330       340
                  ....*....|....*....|....*...
gi 1720416754 544 fhptlrSTRRFYPHTHNMDGFFIAKFKK 571
Cdd:PRK10901  405 ------PGRQLLPGEEDGDGFFYALLIK 426
PRK14903 PRK14903
16S rRNA methyltransferase B; Provisional
 257-527 1.63e-36

16S rRNA methyltransferase B; Provisional


Pssm-ID: 184896 [Multi-domain]  Cd Length: 431  Bit Score: 143.09  E-value: 1.63e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 257 KDLATYYSYGDFLLSKLMELFPLSELIEFLEANEVPRPITLRTNTLKTRRRDLAQALINRGVNLDPlGKWSKSGLVVYDS 336
Cdd:PRK14903  126 KELHLKYSHPKWLVNYWRSFLPEEAVLRIMEWNQEPLPTMLRVNSLAITREEVIKILAEEGTEAVP-GKHSPFSLIVRKL 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 337 SVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHR 416
Cdd:PRK14903  205 GVNMNDSRVIKDGLATVQGESSQIVPLLMELEPGLRVLDTCAAPGGKTTAIAELMKDQGKILAVDISREKIQLVEKHAKR 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 417 LGVTNTIISHYDGRQFPKVVGG-FDRVLLDAPCSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLLSAIDSVnaasKTGG 495
Cdd:PRK14903  285 LKLSSIEIKIADAERLTEYVQDtFDRILVDAPCTSLGTARNHPEVLRRVNKEDFKKLSEIQLRIVSQAWKLL----EKGG 360

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1720416754 496 YLVYCTCSITVEENEWVV-DYALKKRNVRLVPT 527
Cdd:PRK14903  361 ILLYSTCTVTKEENTEVVkRFVYEQKDAEVIDI 393
PRK14904 PRK14904
16S rRNA methyltransferase B; Provisional
 220-519 1.65e-35

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237858 [Multi-domain]  Cd Length: 445  Bit Score: 140.19  E-value: 1.65e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 220 DLQRVHK--RIQDIV-GVLRDFGAQRE------EGRSRAEYLSRLqkdlatyYSYGDFLLSKLMELFPLSELIEFLEANE 290
Cdd:PRK14904  104 KLARKYKgeHMAKLVnGVLRNISPETIsldewlKGMPEAERLSLL-------YSHPEWLLERWIARYGEERTEAMLSYNN 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 291 VPRPITLRTNTLKTRRRDLAQALINRGVnldplgKWSKSGLVVYDSSVPIGATPEYLA-GHYMLQGASSMLPVMALAPQE 369
Cdd:PRK14904  177 QAPLFGFRINRLKTTPEKFLAAPADASV------TFEKSGLPNFFLSKDFSLFEPFLKlGLVSVQNPTQALACLLLNPQP 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 370 HERILDMCCAPGGKTSYIAQLMKNTGVILANDANADRLKSVVGNLHRLGVtnTIIS--HYDGRQFPKvVGGFDRVLLDAP 447
Cdd:PRK14904  251 GSTVLDLCAAPGGKSTFMAELMQNRGQITAVDRYPQKLEKIRSHASALGI--TIIEtiEGDARSFSP-EEQPDAILLDAP 327

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1720416754 448 CSGTGVISKDPAVKTNKDEKDIQRCAHLQKELLlsaidsVNAAS--KTGGYLVYCTCSITVEENEWVVDYALKK 519
Cdd:PRK14904  328 CTGTGVLGRRAELRWKLTPEKLAELVGLQAELL------DHAASllKPGGVLVYATCSIEPEENELQIEAFLQR 395
Methyltr_RsmF_N pfam17125
N-terminal domain of 16S rRNA methyltransferase RsmF; This is the N-terminal domain of the ...
 284-358 1.28e-08

N-terminal domain of 16S rRNA methyltransferase RsmF; This is the N-terminal domain of the RsmF methyl transferase. RsmF is a multi-site-specific methyltransferase that is responsible for the synthesis of three modifications on cytidines in 16S ribosomal RNA. The N-terminus is critical for stabilising the catalytic core of the enzyme.


Pssm-ID: 465356 [Multi-domain]  Cd Length: 88  Bit Score: 52.48  E-value: 1.28e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720416754 284 EFLEANEVPRPITLRTNTLKTRRRDLAQALinrGVNLDPLgKWSKSGLvVYDSSVPIGATPEYLAGHYMLQGASS 358
Cdd:pfam17125  19 AFLAAYDEPRPVGLRVNTLKISVEEFLKLS---PFELEPV-PWCEEGF-YLEERPRPGKHPYHHAGLYYIQEPSA 88
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 372-500 8.79e-06

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 45.11  E-value: 8.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 372 RILDMCCAPGGKTSYIAQLMKntGVILANDANADRLKSVVGNLHRLGVTNTIISHYDGRQFPKV-VGGFDRVLLDAPCsg 450
Cdd:cd02440     1 RVLDLGCGTGALALALASGPG--ARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPEaDESFDVIISDPPL-- 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1720416754 451 tgviskdpavktnkdekdiqrcaHLQKELLLSAIDSVNAASKTGGYLVYC 500
Cdd:cd02440    77 -----------------------HHLVEDLARFLEEARRLLKPGGVLVLT 103
PHA03247 PHA03247
large tegument protein UL36; Provisional
 577-794 6.54e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 46.86  E-value: 6.54e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754  577 PQPHA-----GNSAAATPTEPDLKDQVTPKSENGSQPTKKARGA-VKAKQQLLRQPHSKKPFQKLNGIAKGPGLSTEP-S 649
Cdd:PHA03247  2631 PSPAAnepdpHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAqASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPeP 2710

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754  650 VPDAQVSTRP----SQSAGNADVNSKRKRSEKLKQRGPKwKPSKEAAVPKPSAPSrvedsrTPPVPTPSEIRAAPRPKDC 725
Cdd:PHA03247  2711 APHALVSATPlppgPAAARQASPALPAAPAPPAVPAGPA-TPGGPARPARPPTTA------GPPAPAPPAAPAAGPPRRL 2783

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720416754  726 AP----SLGEAKKKQKGKQQLAQQPANGAAPLKEDAVSKGPSAPFVSPHSSTRPPPAKrrksmTKGNSQPLLS 794
Cdd:PHA03247  2784 TRpavaSLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP-----PPGPPPPSLP 2851
P120R pfam08062
P120R (NUC006) repeat; This characteriztic repeat of proliferating cell nuclear antigen P120 ...
 609-630 8.43e-04

P120R (NUC006) repeat; This characteriztic repeat of proliferating cell nuclear antigen P120 is found in three copies.


Pssm-ID: 285324  Cd Length: 22  Bit Score: 37.08  E-value: 8.43e-04
                          10        20
                  ....*....|....*....|..
gi 1720416754 609 TKKARGAVKAKQQLLRQPHSKK 630
Cdd:pfam08062   1 AGKAKGAEKRKQQLLKQPHPKK 22
PHA03247 PHA03247
large tegument protein UL36; Provisional
 579-776 2.36e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.36e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754  579 PHAGNSAAATPTEPDLKDQVTPKSENGSQPTKKARGAVKAKQQLLRQPHSKKPfqklngiakgPGLSTEPSVPDAQVSTR 658
Cdd:PHA03247  2819 PPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSP----------AAKPAAPARPPVRRLAR 2888

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754  659 PSQSagnadvnsKRKRSEKLKQRGPKWKPSKEAAV-PKPSAPSRVEDSRTPPVPTPSEIRAAPRPKDCAPSLGEAKKKQK 737
Cdd:PHA03247  2889 PAVS--------RSTESFALPPDQPERPPQPQAPPpPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVP 2960

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1720416754  738 GKQQLAQQPANGAAPlKEDAVSKGPSAPfvSPHSSTRPP 776
Cdd:PHA03247  2961 QPWLGALVPGRVAVP-RFRVPQPAPSRE--APASSTPPL 2996
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
577-780 4.04e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.63  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 577 PQPHAGNSAAATPTEPDLKDQVTPKSENGSQPTKKARGAVKAKQQLLRQPHSKKPFQKLNGIAKGPGlSTEPSVPDAQVS 656
Cdd:PRK12323  385 PAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA-PAPAAAPAAAAR 463

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754 657 TRPSQSAGNADVNSKRKRSEklkQRGPKWKPSKEAAVPKPSAPSrvedsrTPPVPTPSEIRAAPRPKDCAPSLGEAkKKQ 736
Cdd:PRK12323  464 PAAAGPRPVAAAAAAAPARA---APAAAPAPADDDPPPWEELPP------EFASPAPAQPDAAPAGWVAESIPDPA-TAD 533

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1720416754 737 KGKQQLAQQPANGAAPLkedAVSKGPSAPFVSPhsstRPPPAKR 780
Cdd:PRK12323  534 PDDAFETLAPAPAAAPA---PRAAAATEPVVAP----RPPRASA 570
PHA03247 PHA03247
large tegument protein UL36; Provisional
 581-785 4.12e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 4.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754  581 AGNSAAATPTEPDLKDQVTPKSENGSQPTKKARGAVKAKQQLLRQPHSKKPfqklngiAKGPGLSTEPS----VPDAQVS 656
Cdd:PHA03247  2791 LSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP-------PPGPPPPSLPLggsvAPGGDVR 2863

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754  657 TR-PSQSAGNADVNSKRKRSEKLKQRGPKWKPSKEAAVPKPSAPSRVEDSRTPPVPTPS-EIRAAPRPKDCAPSLGEAKK 734
Cdd:PHA03247  2864 RRpPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQpPPPPQPQPPPPPPPRPQPPL 2943

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1720416754  735 KQKGKQQLAQQPANGAAPLKEDAVSKGPSA---PFVSPHSSTRPPPAKRRKSMT 785
Cdd:PHA03247  2944 APTTDPAGAGEPSGAVPQPWLGALVPGRVAvprFRVPQPAPSREAPASSTPPLT 2997
PHA03247 PHA03247
large tegument protein UL36; Provisional
 642-779 9.44e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 9.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720416754  642 PGLSTEPSVPDAQVSTRPSQSAgnadVNSKRKRSEKLKQRGPKWKPSKEAAVPK-PSAPSRVEDSRTPPVPTPSeiraAP 720
Cdd:PHA03247  2560 PPAAPDRSVPPPRPAPRPSEPA----VTSRARRPDAPPQSARPRAPVDDRGDPRgPAPPSPLPPDTHAPDPPPP----SP 2631

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720416754  721 RPKDCAPSLGEAkKKQKGKQQLAQQPANGAAPLKEDAVSKGPSAPFVSPHSSTRPPPAK 779
Cdd:PHA03247  2632 SPAANEPDPHPP-PTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAAR 2689
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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