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Conserved domains on  [gi|1720417469|ref|XP_030111143|]
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alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform X4 [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 20-200 1.08e-136

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23989:

Pssm-ID: 480271  Cd Length: 272  Bit Score: 383.80  E-value: 1.08e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVG 99
Cdd:cd23989    92 RCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYYTLADVG 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469 100 ANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGYHA 179
Cdd:cd23989   172 ANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGFHA 251

                         170       180
                  ....*....|....*....|.
gi 1720417469 180 MPEEFLQLWYLHKIGALRMQL 200
Cdd:cd23989   252 MPEEFLQLWHLHKSGVLRMQL 272
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 20-200 1.08e-136

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 383.80  E-value: 1.08e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVG 99
Cdd:cd23989    92 RCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYYTLADVG 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469 100 ANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGYHA 179
Cdd:cd23989   172 ANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGFHA 251

                         170       180
                  ....*....|....*....|.
gi 1720417469 180 MPEEFLQLWYLHKIGALRMQL 200
Cdd:cd23989   252 MPEEFLQLWHLHKSGVLRMQL 272
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 20-195 6.10e-69

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 211.31  E-value: 6.10e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSsEYTRDVGSKTQLVTANP-SIIRQRFENLLWS--RKKFVDNMKIYNH--SYIYMPAFSMKTGTEPSLRVYYT 94
Cdd:pfam00777  72 RCNLAPTK-GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYT 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  95 LKDVGANQT---VLFANPNFLRNIGKFW-KSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFsvnMQGDPISHHYYDN 170
Cdd:pfam00777 151 LKEVKIPVDpdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDN 227

                         170       180
                  ....*....|....*....|....*....
gi 1720417469 171 VLP----FSGYHAMPEEFLQLWYLHKIGA 195
Cdd:pfam00777 228 VLMkkggFYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 20-200 1.08e-136

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 383.80  E-value: 1.08e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVG 99
Cdd:cd23989    92 RCNLPPLSREYTDDVGTKTQLVTANPSIIDKRFQNLLWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRVYYTLADVG 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469 100 ANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGYHA 179
Cdd:cd23989   172 ANQTVLFANPNFLRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYYDNVLPDSGFHA 251

                         170       180
                  ....*....|....*....|.
gi 1720417469 180 MPEEFLQLWYLHKIGALRMQL 200
Cdd:cd23989   252 MPEEFLQLWHLHKSGVLRMQL 272
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 20-200 3.27e-115

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 329.22  E-value: 3.27e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSseYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVG 99
Cdd:cd23971    93 RCNLPPLN--DSKDVGSKTNLVTANPSILREKFHNLKKRRRPFVERMKVYGNALLLLPAFSYTSNTEPSLRALYTLEDFG 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469 100 ANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGYHA 179
Cdd:cd23971   171 SPQKVLFFNPEYLRNLSRYWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYYDNVLPKKGVHA 250

                         170       180
                  ....*....|....*....|.
gi 1720417469 180 MPEEFLQLWYLHKIGALRMQL 200
Cdd:cd23971   251 MPEEFLRYLKLHSQGVLRLHL 271
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 20-200 2.98e-82

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 245.82  E-value: 2.98e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVG 99
Cdd:cd23991    93 RCNLPPTGGNISKDVGSKTNLVTANPSIISIKYAKLNERRKPFLETVSVYGDAFLLLPAFSYRSNTALSFKVYYTLEDFK 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469 100 ANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGYHA 179
Cdd:cd23991   173 AKQKVIFFHPIYLKHLAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQLPKPGFHS 252

                         170       180
                  ....*....|....*....|.
gi 1720417469 180 MPEEFLQLWYLHKIGALRMQL 200
Cdd:cd23991   253 MPKEFYQLLQLHSKGILKLQF 273
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 20-200 4.96e-74

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 224.83  E-value: 4.96e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKD 97
Cdd:cd23963    92 RCNLPPIK-GFEKDVGRKTNLTTLNPSILKRRYNSLKknRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLLLKAARALKK 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  98 VGANQTVLFANPNFLRNIGKFWKSRGIhAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLP--FS 175
Cdd:cd23963   171 NGLNLTVVYSNPEHFLAVQKFWKRRGL-EKRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYYDDLSPstKN 249

                         170       180
                  ....*....|....*....|....*
gi 1720417469 176 GYHAMPEEFLQLWYLHKIGALRMQL 200
Cdd:cd23963   250 KVHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 20-195 6.10e-69

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 211.31  E-value: 6.10e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSsEYTRDVGSKTQLVTANP-SIIRQRFENLLWS--RKKFVDNMKIYNH--SYIYMPAFSMKTGTEPSLRVYYT 94
Cdd:pfam00777  72 RCNLAPTK-GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFShpRDPFVEFVLVPFKgrDLLWLPAFLTKGNVSRSLRVLYT 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  95 LKDVGANQT---VLFANPNFLRNIGKFW-KSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFsvnMQGDPISHHYYDN 170
Cdd:pfam00777 151 LKEVKIPVDpdkVLFLHPDFLRYVANFWlRSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDN 227

                         170       180
                  ....*....|....*....|....*....
gi 1720417469 171 VLP----FSGYHAMPEEFLQLWYLHKIGA 195
Cdd:pfam00777 228 VLMkkggFYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 20-198 9.13e-67

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 206.23  E-value: 9.13e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKDVG 99
Cdd:cd23990    93 RCNLPPISEKYVRDVGVKTDVVTINPSIITERFHKLEKWRRPFYEVLQVYENASVVLPAFYNTRNTDVSIRVKYVLDDFE 172

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469 100 ANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNVLPFSGYHA 179
Cdd:cd23990   173 SQQAVYYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYYDNVKPRPGFHA 252

                         170
                  ....*....|....*....
gi 1720417469 180 MPEEFLQLWYLHKIGALRM 198
Cdd:cd23990   253 MPSEIFNFLHMHSRGILRV 271
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 20-200 4.23e-45

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 151.01  E-value: 4.23e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSSeYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKTGTEPSLRVYYTLKD 97
Cdd:cd23970    97 RCNFAPTEG-FEKDVGRKTNLTTFNPSILEKYYNNLLtiQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVE 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  98 VGANQTVLFANP-NFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDN-----V 171
Cdd:cd23970   176 HRGQLKVQLAWPgNIMQHVNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPTGTPLPYHYYDKkgtkfT 255

                         170       180
                  ....*....|....*....|....*....
gi 1720417469 172 LPFSGYHAMPEEFLQLWYLHKIGALRMQL 200
Cdd:cd23970   256 TKWQESHQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 20-199 8.38e-45

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 150.26  E-value: 8.38e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLLWS--RKKFVDNMKIYNHSYIYMPAFSMKTGTEpslRVYYTLKD 97
Cdd:cd23969    93 RCNLAPVE-GYEKDVGTKSNLTTMNPSVIPHAYGDLVNAtdKEKFVERLRQLGDSILWIPAFVSKGGEE---HVQWTNEI 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  98 V---GANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNvLPF 174
Cdd:cd23969   169 IlkhKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYHYYDN-RKY 247

                         170       180
                  ....*....|....*....|....*...
gi 1720417469 175 S---GYHAMPEEFLQLWYLHKIGALRMQ 199
Cdd:cd23969   248 LttaRPHKMPEEFRALRSLHQRGALRLH 275
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 20-198 1.55e-39

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 136.61  E-value: 1.55e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLL---WsRKKFVDNMKIYNHSYIYMPAFSMKTGTEpslRVYYTLK 96
Cdd:cd23987    93 RCNLAPVE-EYAKDVGTKTDLVTMNPSVVQRAFEDLVnetW-KEKFLQRLQSLNGSILWIPAFMAKGGEE---RVEWVND 167

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  97 DV---GANQTVLFANPNFLRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNV-- 171
Cdd:cd23987   168 LIlkhHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYHYYDSLky 247

                         170       180
                  ....*....|....*....|....*....
gi 1720417469 172 --LPFSGYHAMPEEFLQLWYLHKIGALRM 198
Cdd:cd23987   248 gyTSQASPHTMPLEFKALKNLHQQGALKL 276
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 20-198 6.53e-35

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 124.68  E-value: 6.53e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPLSsEYTRDVGSKTQLVTANPSIIRQRFENLL--WSRKKFVDNMKIYNHSYIYMPAFSMKTGTEpslRVYYTLKD 97
Cdd:cd23988    93 RCNLAPVV-EFAADVGTKSDFITMNPSVVQRAFGGFRneSDREKFVHRLSMLNDSVLWIPAFMVKGGEK---HVEWVNAL 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  98 VGANQ-TVLFANPNF--LRNIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPISHHYYDNV--- 171
Cdd:cd23988   169 ILKNKlKVRTAYPSLrlIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYHYYDDLkyr 248

                         170       180
                  ....*....|....*....|....*...
gi 1720417469 172 -LPFSGYHAMPEEFLQLWYLHKIGALRM 198
Cdd:cd23988   249 yFSNAGPHRMPLEFKTLNVLHNRGALKL 276
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 20-184 7.64e-13

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 64.31  E-value: 7.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRFENLLWSRKKFVDNMKIYnhsYIYMPAFsmktgTEPSLRVYYTLKDVG 99
Cdd:cd19952    27 RFNQAP-TKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPLEEEVV---LILSRAA-----AADFKRLKRRKKRHD 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469 100 ANQT-VLFANPNF-------LRNIGKFWKSRGIHAkrlSTGLFLVSAALGLCEEVSIYGFWPFSVNMQGDPisHHYYDNV 171
Cdd:cd19952    98 NAVLlLTDPAPDLlsyvrkrLEKLGLKSFFGGNAP---SSGLLAVLLALQLCDSVDLYGFGVDSGHAPKVP--YHYYDLV 172

                         170
                  ....*....|....*
gi 1720417469 172 LP--FSGYHAMPEEF 184
Cdd:cd19952   173 EAeeGTAVHSFDLEA 187
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 26-197 8.24e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 62.66  E-value: 8.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  26 LSSEYTRDVGSKTQLVTANP--SIIRQRFENLLWSRKKFVDNM-KIYnhSYIYMPAFS----MKTGTEPSLRVYYTLKDV 98
Cdd:cd23964   116 LTKGFEKDVGTKTSFYTFFPesLHNSLLKHVPQDKDTKYLFIPfKIR--DYDYLDAVLsgkpVPDGCDKGKRPPPLFGPK 193

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  99 GANQTVLFANPNFLRNIGKFW-KSRGIHakRLSTGLFLVSAALGLCEEVSIYGF---WPFSVnmqgdpishHYYDN---- 170
Cdd:cd23964   194 LNATNVRLLHPDFIRYLFNRWlNSSTSY--RPTTGALMLLTALHTCDQVSVYGFgydPRFSL---------HYYDKtfvk 262

                         170       180
                  ....*....|....*....|....*...
gi 1720417469 171 VLPFSGYHAMPEEfLQLW-YLHKIGALR 197
Cdd:cd23964   263 FTVFYANHDFTNE-RKLWrKLHEEGIIN 289
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 93-198 2.33e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 47.05  E-value: 2.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  93 YTLKDVGANQTVLFaNPNFLRNI-GKFWKSRGIHAK-----RLSTGLFLVSAALGLCEEVSIYGFwpfsVNMQGDPISHH 166
Cdd:cd23974   198 YFGKDVTAEKFKIY-HPDFIRYLrNRFLWSPILNTKqrdiyRPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKYSDH 272

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1720417469 167 YYDNV---LPFSGYHAMPEEfLQLWY-LHKIGALRM 198
Cdd:cd23974   273 YYDKTyhkVVFYANHDLRLE-MQLWQkLHKAGLIKL 307
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 90-198 4.38e-06

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 46.12  E-value: 4.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  90 RVYYTLKD-VGANQT-VLFANPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAALGLCEEVSIYGfwpFSVNMQGDpiSHHY 167
Cdd:cd23966   166 RTYTPVKRfIKADKDkVLVINPAFIKYVHDNWTEH--HGRYPSTGFLALIFALHICDEVSVFG---FGADSKGN--WHHY 238

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1720417469 168 YDNVLPFS-----GYHAMPEEFLQLWYLHKIGALRM 198
Cdd:cd23966   239 WEKNRSAGafrktGVHDADFESDIIKKLAKEGKIRV 274
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 6-169 2.50e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 43.69  E-value: 2.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469   6 TRSPSIIPRTPSSPRCNLPPLSSeYTRDVGSKTQL-VTANPSIIRqrfenLLWSRKKFVDnmKIYNHSYIYM-PAFSMKT 83
Cdd:cd23978    16 TSLGPEIDQTECTIRMNDAPTTG-YEKDVGNKTTLrVVAHSSVYR-----VLRRPQEFLN--RTPETTLIFWgPPNKMQK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  84 GTEPSL-RVYYTLKDVGANQTVLFANPNFLRNIGKFW-----KSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPF--- 154
Cdd:cd23978    88 DGKSNLfRIIQRASMTFPNMSAFVVSPRRMRQFDDLFrgetgRDRKKSHSWLSTGWFTMVIAVELCDNVHVYGMVPPnyc 167

                         170
                  ....*....|....*
gi 1720417469 155 SVNMQGDPISHHYYD 169
Cdd:cd23978   168 SKRPTPKKMPYHYYE 182
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 108-193 2.72e-05

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 43.43  E-value: 2.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469 108 NPNFLR----NIGKFWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFwPFSVNMQGDPIshHYYDNVL----PFSGYHA 179
Cdd:cd23967   118 NPYILQeaafDLIGLPMNGKQGKNVPTTGIIAIVMALHYCDEVDIAGF-GYDPSDPNAPL--HYYDSLTmkaiKRSWTHN 194

                          90
                  ....*....|....
gi 1720417469 180 MPEEFLqlwYLHKI 193
Cdd:cd23967   195 VTKEKK---YLKKL 205
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 30-173 4.54e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 42.93  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  30 YTRDVGSKTQL-VTANPS---IIRQRFENLLWSRKKFV------DNMK------IYNHsyiympaFSMKTGTEPSLRVYY 93
Cdd:cd23976    53 YGKDVGNKTSLrVIAHSSiqrILRNRNELLNVSQGTVFifwgpsNYMRrdgkglVYNN-------LQLMNQILPKLKVYT 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  94 TLKdvganQTVLFANPNFLRNIGKfwkSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWP--FSVNMQGDPISHHYYDNV 171
Cdd:cd23976   126 ITR-----HKMLQFDELFKRETGK---DRKISNTWLSTGWFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPS 197


                  ..
gi 1720417469 172 LP 173
Cdd:cd23976   198 GP 199
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 30-169 1.46e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 41.46  E-value: 1.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  30 YTRDVGSKTQL-VTANPSIIRQRFENLLWSRKKFVDNMKIynhsyIYMPAFSMKTGTEPSLRV------------YYTLK 96
Cdd:cd23965    39 YEKDVGRRTTIrVVSHSSLPRLLRNAILLLAGTRAPTVVV-----FWGPETKMNKDGAGKYNLlrslskkypdveFYSLT 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1720417469  97 DVGanqtVLFANPNFLRNIGKfwkSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWP--FSVNMQGDPISHHYYD 169
Cdd:cd23965   114 PEK----MDYADELFEKETGK---SRIKSGTWLSTGWFTMLLALDVCDEIKVYGMVPenYCREHPNSKVPYHYYE 181
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 108-198 1.76e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 41.35  E-value: 1.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469 108 NPNFLRNI-GKFWKSRGI-----HAKRLSTGLFLVSAALGLCEEVSIYGFwpfsVNMQGDPISHHYYDNV---LPFSGYH 178
Cdd:cd23972   210 HPDFISYLtDRFLKSKLLnthygHLYMPSTGALMLLTALHTCDQVSAYGF----ITSNYWKFSDHYYERKkkpLVFYANH 285

                          90       100
                  ....*....|....*....|.
gi 1720417469 179 AMPEEfLQLW-YLHKIGALRM 198
Cdd:cd23972   286 DMLLE-AALWrRLHKAGILQL 305
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 105-198 1.89e-04

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 41.28  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469 105 LFANPNFLRNI-GKFWKSRGIHAK-----RLSTGLFLVSAALGLCEEVSIYGFwpfsvnMQGD--PISHHYYDNV---LP 173
Cdd:cd23973   208 LVLHPDFLRYVkNRFLRSKTLKGKywaiyRPTTGAFLLLTALHLCDTVSAYGF------ITEDyrKYPDHYYDKKktkLV 281

                          90       100
                  ....*....|....*....|....*.
gi 1720417469 174 FSGYHAMPEEfLQLW-YLHKIGALRM 198
Cdd:cd23973   282 FYINHDFRLE-KKLWkRLHDEKIIKL 306
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 20-170 4.28e-04

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 40.25  E-value: 4.28e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPlSSEYTRDVGSKTQLVTANPSIIRQRFEN--LLWSRKKFVDNMKIY--------NHSYIYMPAfsmktgtepSL 89
Cdd:cd23980   110 RMNKAP-TEGFEADVGSKTTHHFVYPESFRELAQNvsMILVPFKTLDLEWVIsatttgtiSHTYVPVPR---------KI 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  90 RVyytlkdvgANQTVLFANPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAALGLCEEVSIYGfwpFSVNMQGDpiSHHYYD 169
Cdd:cd23980   180 KV--------KKEKILIYHPAFIKYVFDRWLQG--HGRYPSTGILSVIFSLHVCDEVDLYG---FGADSKGN--WHHYWE 244


                  .
gi 1720417469 170 N 170
Cdd:cd23980   245 N 245
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 108-170 1.62e-03

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 38.31  E-value: 1.62e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1720417469 108 NPNFLRNIGKFWKSRgiHAKRLSTGLFLVSAALGLCEEVSIYGfwpFSVNMQGDpiSHHYYDN 170
Cdd:cd23979   189 NPAFFKYIHDRWTEH--HGRYPSTGMLVLFFALHVCDEVNVYG---FGADSRGN--WHHYWEN 244
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 130-172 3.24e-03

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 37.34  E-value: 3.24e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1720417469 130 STGLFLVSAALGLCEEVSIYGF-WPFSVNmQGDPIshHYYDNVL 172
Cdd:cd23982   143 TTGLLAITLALHLCDEVHIAGFgYPDNGN-SNQPI--HYYNQIT 183
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 30-183 6.51e-03

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 36.48  E-value: 6.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  30 YTRDVGSKT-------QLVTAN-----PSIIRQRFENLLWSRKKFVDNMKI--YNHSYIYMPAFSMKTGTEPSLRVYytl 95
Cdd:cd23968    83 FEKDVGSKTtlrlinsQILSKPefnflTDPLYRNVTLLVWDPSSYNVNLEKwyKKPDFDFFPNYIKYRRRHPEEPFY--- 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  96 kdvganqtvlFANPNFLRNIgkfWK------SRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPfsvNMQGDPIShHYYD 169
Cdd:cd23968   160 ----------LIDPRFLWRL---WDilqeytPEKIKPNPPSSGFIGIVLMLHLCDWVDVYEYVP---SVRQTDRC-HYYD 222

                         170
                  ....*....|....*...
gi 1720417469 170 NVL----PFSGYHAMPEE 183
Cdd:cd23968   223 VEKdlacTLGAWHPLAAE 240
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 20-169 6.98e-03

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 36.38  E-value: 6.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  20 RCNLPPlSSEYTRDVGSKTQLV----TANPSIIRQR---FEN------LLWSRKKFVDNMKiynhSYIYMPAFSMKTGTE 86
Cdd:cd23977    30 RMNVAP-TAGYEADVGNRSSLRvvshTSVPLLLRNQgyfFQQsrdtkyVIWGPERNMDRDG----GGKTYRALLTLAKMY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417469  87 PSLRVYYTLKDVGANQTVLFANPNflrnigkfWKSRGIHAKRLSTGLFLVSAALGLCEEVSIYGFWPFSV--NMQGDPIS 164
Cdd:cd23977   105 PHLQVYTLTEEKMAYCDGVFQNET--------GKNRMKSGSFLSTGWFTMILALELCEEILVYGMVSDSYcrNKNHSSVP 176


                  ....*
gi 1720417469 165 HHYYD 169
Cdd:cd23977   177 YHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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