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Conserved domains on  [gi|1720417536|ref|XP_030111159|]
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proline-rich transmembrane protein 3 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK07764 super family cl35613
DNA polymerase III subunits gamma and tau; Validated
273-447 6.82e-06

DNA polymerase III subunits gamma and tau; Validated


The actual alignment was detected with superfamily member PRK07764:

Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.98  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 273 PEGLPAEPPKTGAGDTWEVSSLGPQPEQTDLLGGQDSPAPQPIPPSASDTSDghlrpvSSLNGADPISPQRVRGAMEAPG 352
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASA------APAPGVAAPEHHPKHVAVPDAS 663
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 353 TPKSFIPDLPNSAQAANGTESPVRALQPDEAEDWPGRPQSHPPAPPVQAPSTSRRGLVRVTTQRAL--------GQPLPP 424
Cdd:PRK07764  664 DGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASapspaaddPVPLPP 743
                         170       180
                  ....*....|....*....|...
gi 1720417536 425 EPSASSIVPIPASSPPANATAPP 447
Cdd:PRK07764  744 EPDDPPDPAGAPAQPPPPPAPAP 766
PHA03247 super family cl33720
large tegument protein UL36; Provisional
64-463 2.26e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536   64 SGDPQARAEGPKKPADPYLGPALHGPKAAPGVQGERLLRADDLQLARAFTSQGWTGP--PDS----QELLEPEAPEPHPV 137
Cdd:PHA03247  2630 SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRaaRPTvgslTSLADPPPPPPTPE 2709
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  138 RAPRlTLVTTTPSSLLSAAILSTASQKPGGTAGQQPARNeelimvkAETHITQASPWDFQGSSHTPVPETDAVRTLVLGK 217
Cdd:PHA03247  2710 PAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-------PATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  218 QGGHEQGFQEAVQGPLL-TQQDPVVPGVGSTPPVKVESTPEPGAQLDLALVRSLPLPEGLPAEPPKTGAGDTWEVSSLGP 296
Cdd:PHA03247  2782 RLTRPAVASLSESRESLpSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD 2861
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  297 QPEQtdllGGQDSPAPQPIPPSasdtsdghlRPVSSLNGADPISPQRVRGAMEAPGTPKsfiPDLPNSAQAANGTESPVR 376
Cdd:PHA03247  2862 VRRR----PPSRSPAAKPAAPA---------RPPVRRLARPAVSRSTESFALPPDQPER---PPQPQAPPPPQPQPQPPP 2925
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  377 ALQPDEAEDWPGRPQSHPPAPPVQAPSTSRRGLVRVTTQRALGQPLPPEPSASSIVPIPASSPPANATaPPLRWGPLRRV 456
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASST-PPLTGHSLSRV 3004

                   ....*..
gi 1720417536  457 LSFSWEL 463
Cdd:PHA03247  3005 SSWASSL 3011
 
Name Accession Description Interval E-value
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
273-447 6.82e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.98  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 273 PEGLPAEPPKTGAGDTWEVSSLGPQPEQTDLLGGQDSPAPQPIPPSASDTSDghlrpvSSLNGADPISPQRVRGAMEAPG 352
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASA------APAPGVAAPEHHPKHVAVPDAS 663
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 353 TPKSFIPDLPNSAQAANGTESPVRALQPDEAEDWPGRPQSHPPAPPVQAPSTSRRGLVRVTTQRAL--------GQPLPP 424
Cdd:PRK07764  664 DGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASapspaaddPVPLPP 743
                         170       180
                  ....*....|....*....|...
gi 1720417536 425 EPSASSIVPIPASSPPANATAPP 447
Cdd:PRK07764  744 EPDDPPDPAGAPAQPPPPPAPAP 766
PHA03247 PHA03247
large tegument protein UL36; Provisional
64-463 2.26e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536   64 SGDPQARAEGPKKPADPYLGPALHGPKAAPGVQGERLLRADDLQLARAFTSQGWTGP--PDS----QELLEPEAPEPHPV 137
Cdd:PHA03247  2630 SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRaaRPTvgslTSLADPPPPPPTPE 2709
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  138 RAPRlTLVTTTPSSLLSAAILSTASQKPGGTAGQQPARNeelimvkAETHITQASPWDFQGSSHTPVPETDAVRTLVLGK 217
Cdd:PHA03247  2710 PAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-------PATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  218 QGGHEQGFQEAVQGPLL-TQQDPVVPGVGSTPPVKVESTPEPGAQLDLALVRSLPLPEGLPAEPPKTGAGDTWEVSSLGP 296
Cdd:PHA03247  2782 RLTRPAVASLSESRESLpSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD 2861
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  297 QPEQtdllGGQDSPAPQPIPPSasdtsdghlRPVSSLNGADPISPQRVRGAMEAPGTPKsfiPDLPNSAQAANGTESPVR 376
Cdd:PHA03247  2862 VRRR----PPSRSPAAKPAAPA---------RPPVRRLARPAVSRSTESFALPPDQPER---PPQPQAPPPPQPQPQPPP 2925
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  377 ALQPDEAEDWPGRPQSHPPAPPVQAPSTSRRGLVRVTTQRALGQPLPPEPSASSIVPIPASSPPANATaPPLRWGPLRRV 456
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASST-PPLTGHSLSRV 3004

                   ....*..
gi 1720417536  457 LSFSWEL 463
Cdd:PHA03247  3005 SSWASSL 3011
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
222-448 7.57e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 222 EQGFQEAVQGPLLTQQDPVVPGVGSTPPVKVESTPEPGAQLDLALVRSLPLPEGLPAEPPKTGAGDTWEVSSLGPQPEQT 301
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 302 DLLGGQDSPAPQPIPPSASDTSDghlRPVSSLNGADPISPQRVRGA---MEAPGTPKSFiPDLPNSAQAaNGTESPVRAL 378
Cdd:pfam03154 243 PSPHPPLQPMTQPPPPSQVSPQP---LPQPSLHGQMPPMPHSLQTGpshMQHPVPPQPF-PLTPQSSQS-QVPPGPSPAA 317
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 379 qPDEAEDWPGRPQSHPPAPPVQAPSTsrrglvrvttqralgQPLPPEPsassiVPIPASSPPANATAPPL 448
Cdd:pfam03154 318 -PGQSQQRIHTPPSQSQLQSQQPPRE---------------QPLPPAP-----LSMPHIKPPPTTPIPQL 366
 
Name Accession Description Interval E-value
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
273-447 6.82e-06

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.98  E-value: 6.82e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 273 PEGLPAEPPKTGAGDTWEVSSLGPQPEQTDLLGGQDSPAPQPIPPSASDTSDghlrpvSSLNGADPISPQRVRGAMEAPG 352
Cdd:PRK07764  590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASA------APAPGVAAPEHHPKHVAVPDAS 663
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 353 TPKSFIPDLPNSAQAANGTESPVRALQPDEAEDWPGRPQSHPPAPPVQAPSTSRRGLVRVTTQRAL--------GQPLPP 424
Cdd:PRK07764  664 DGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASapspaaddPVPLPP 743
                         170       180
                  ....*....|....*....|...
gi 1720417536 425 EPSASSIVPIPASSPPANATAPP 447
Cdd:PRK07764  744 EPDDPPDPAGAPAQPPPPPAPAP 766
PHA03247 PHA03247
large tegument protein UL36; Provisional
64-463 2.26e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 48.78  E-value: 2.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536   64 SGDPQARAEGPKKPADPYLGPALHGPKAAPGVQGERLLRADDLQLARAFTSQGWTGP--PDS----QELLEPEAPEPHPV 137
Cdd:PHA03247  2630 SPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRaaRPTvgslTSLADPPPPPPTPE 2709
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  138 RAPRlTLVTTTPSSLLSAAILSTASQKPGGTAGQQPARNeelimvkAETHITQASPWDFQGSSHTPVPETDAVRTLVLGK 217
Cdd:PHA03247  2710 PAPH-ALVSATPLPPGPAAARQASPALPAAPAPPAVPAG-------PATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  218 QGGHEQGFQEAVQGPLL-TQQDPVVPGVGSTPPVKVESTPEPGAQLDLALVRSLPLPEGLPAEPPKTGAGDTWEVSSLGP 296
Cdd:PHA03247  2782 RLTRPAVASLSESRESLpSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGD 2861
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  297 QPEQtdllGGQDSPAPQPIPPSasdtsdghlRPVSSLNGADPISPQRVRGAMEAPGTPKsfiPDLPNSAQAANGTESPVR 376
Cdd:PHA03247  2862 VRRR----PPSRSPAAKPAAPA---------RPPVRRLARPAVSRSTESFALPPDQPER---PPQPQAPPPPQPQPQPPP 2925
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  377 ALQPDEAEDWPGRPQSHPPAPPVQAPSTSRRGLVRVTTQRALGQPLPPEPSASSIVPIPASSPPANATaPPLRWGPLRRV 456
Cdd:PHA03247  2926 PPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASST-PPLTGHSLSRV 3004

                   ....*..
gi 1720417536  457 LSFSWEL 463
Cdd:PHA03247  3005 SSWASSL 3011
PRK10263 PRK10263
DNA translocase FtsK; Provisional
237-448 7.13e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 47.00  E-value: 7.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  237 QDPVVPGVGSTP--PVkVESTPEPGAQLDLALVRslPLPEGLPAEP----PKTGAGDTWEvSSLGPQPEQTDLLGGQDSP 310
Cdd:PRK10263   342 QTPPVASVDVPPaqPT-VAWQPVPGPQTGEPVIA--PAPEGYPQQSqyaqPAVQYNEPLQ-QPVQPQQPYYAPAAEQPAQ 417
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  311 APQPIPPSASDTSDGHLRPVSSLNGADPISPQRVRGAMEAPGTPKSFIPDLPNSAQAANGTESPVRALQPDEAEDWPGRP 390
Cdd:PRK10263   418 QPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVE 497
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1720417536  391 QSHPPAPPVQAPSTSRRGLVRVTTQ-RALGQPLpPEPSASSIVPIPASSPPANATAPPL 448
Cdd:PRK10263   498 ETKPARPPLYYFEEVEEKRAREREQlAAWYQPI-PEPVKEPEPIKSSLKAPSVAAVPPV 555
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
67-458 5.46e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 5.46e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536   67 PQARAEGPKKPADPYLGPalhgPKAAPGVQGERLLRADDLQLARAFTSQGWTGPPDSqellePEAPEPHPVRAPRltlVT 146
Cdd:PHA03307    22 PRPPATPGDAADDLLSGS----QGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPG-----PGTEAPANESRST---PT 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  147 TTPSSLLSAAILSTASQKPGGTAGQQPARNEELIMVKAETHITQASPWDFQGSSHTPVPETDAVRTLVLG--KQGGHEQG 224
Cdd:PHA03307    90 WSLSTLAPASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPaaVASDAASS 169
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  225 FQEAVQGPLLTQQDPVVPGVGSTPPVKVESTPEPGAQLDLALVRSLPLPEGLPAePPKTGAGDTWEVSSLGPQPEQTDLL 304
Cdd:PHA03307   170 RQAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPA-PGRSAADDAGASSSDSSSSESSGCG 248
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536  305 GGQDSPAPQPIP-----PSASDTSDGHLRPVSSLNGADPISPQRVRGAMEAPGTPKSFIPDLPNSAQAANGTESPVRALQ 379
Cdd:PHA03307   249 WGPENECPLPRPapitlPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSS 328
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720417536  380 PDEAEDWPGRPQSHPPAPPVQAPSTSRrglvrvtTQRALGQPLPPEPSASSIVPIPASSPPANATAPPLRWGPLRRVLS 458
Cdd:PHA03307   329 TSSSSESSRGAAVSPGPSPSRSPSPSR-------PPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARR 400
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
225-449 1.14e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.94  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 225 FQEAVQGPLLTQQDPVVPGVGSTPPVKVESTPEPGAQLDLALVRSLPLPEGLPAEPPKTGAGDTWEVSSLGPQPEQTDLL 304
Cdd:PRK12323  363 FRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASAR 442
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 305 GGQDSPAPQPIPPS----ASDTSDGHLRPVSSLNGADPISPQRVRGAM----------EAPGTPKSFIPDLPNSAQAANG 370
Cdd:PRK12323  443 GPGGAPAPAPAPAAapaaAARPAAAGPRPVAAAAAAAPARAAPAAAPApadddpppweELPPEFASPAPAQPDAAPAGWV 522
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1720417536 371 TESPVRalqPDEAEDWPGRPQSHPPAPPVQAPSTSRRGLVRVTtqralgqPLPPEPSASSIVPIPASSPPANATAPPLR 449
Cdd:PRK12323  523 AESIPD---PATADPDDAFETLAPAPAAAPAPRAAAATEPVVA-------PRPPRASASGLPDMFDGDWPALAARLPVR 591
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
296-447 6.70e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 40.29  E-value: 6.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 296 PQPEQTDLLGGQDSPAPQPIPPSASDTSDGHLRPVSSLNGADPISPQRVRGAMEAPGTPksfIPDLPNSAQAANGTESPV 375
Cdd:PLN03209  328 VPPKESDAADGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAYEDLKPPTSP---IPTPPSSSPASSKSVDAV 404
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1720417536 376 RALQPDEAEDWPGRPQSHPPAPPVQAPSTSRRGLVRVTTQRALGQPLPPEPSASSIVPIPASSPPA----NATAPP 447
Cdd:PLN03209  405 AKPAEPDVVPSPGSASNVPEVEPAQVEAKKTRPLSPYARYEDLKPPTSPSPTAPTGVSPSVSSTSSvpavPDTAPA 480
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
222-448 7.57e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 7.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 222 EQGFQEAVQGPLLTQQDPVVPGVGSTPPVKVESTPEPGAQLDLALVRSLPLPEGLPAEPPKTGAGDTWEVSSLGPQPEQT 301
Cdd:pfam03154 163 QQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 302 DLLGGQDSPAPQPIPPSASDTSDghlRPVSSLNGADPISPQRVRGA---MEAPGTPKSFiPDLPNSAQAaNGTESPVRAL 378
Cdd:pfam03154 243 PSPHPPLQPMTQPPPPSQVSPQP---LPQPSLHGQMPPMPHSLQTGpshMQHPVPPQPF-PLTPQSSQS-QVPPGPSPAA 317
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 379 qPDEAEDWPGRPQSHPPAPPVQAPSTsrrglvrvttqralgQPLPPEPsassiVPIPASSPPANATAPPL 448
Cdd:pfam03154 318 -PGQSQQRIHTPPSQSQLQSQQPPRE---------------QPLPPAP-----LSMPHIKPPPTTPIPQL 366
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
171-447 9.31e-03

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 40.02  E-value: 9.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 171 QQPARNEELIMVKAETHITQASPWDFQGSSHTPVPetdaVRTlvlgkqgGHEQgFQEAVQGPLLtQQDPVVPGVGSTPPV 250
Cdd:pfam09770 105 QQPAARAAQSSAQPPASSLPQYQYASQQSQQPSKP----VRT-------GYEK-YKEPEPIPDL-QVDASLWGVAPKKAA 171
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 251 KVESTPEPGAQldlalvrslplPEGLPAEPPKtgagdtweVSSL----------GPQPEQTDllggQDSPAPQPIPPSAS 320
Cdd:pfam09770 172 APAPAPQPAAQ-----------PASLPAPSRK--------MMSLeeveaamraqAKKPAQQP----APAPAQPPAAPPAQ 228
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720417536 321 DTSDGHLRPVSSLNGADPispqrvrgameapgtpksfiPDLPNSAQAANGTESPVRALQpdeaedwpgRPQSHPPAPPVQ 400
Cdd:pfam09770 229 QAQQQQQFPPQIQQQQQP--------------------QQQPQQPQQHPGQGHPVTILQ---------RPQSPQPDPAQP 279
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1720417536 401 APSTSrrglvrvtTQRALGQPLPPEPSASSIVPIPASSPPANATAPP 447
Cdd:pfam09770 280 SIQPQ--------AQQFHQQPPPVPVQPTQILQNPNRLSAARVGYPQ 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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