NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1720418655|ref|XP_030111420|]
View 

endoplasmic reticulum-Golgi intermediate compartment protein 2 isoform X7 [Mus musculus]

Protein Classification

COPIIcoated_ERV domain-containing protein( domain architecture ID 10546441)

COPIIcoated_ERV domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
COPIIcoated_ERV pfam07970
Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to ...
 45-207 2.84e-60

Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localization. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.


:

Pssm-ID: 462327  Cd Length: 225  Bit Score: 189.74  E-value: 2.84e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418655  45 CRIHGHLYVNKVAGNFHITVGKAIPHPRGHAH--LAALVNHDSYNFSHRIDHLSFGELVPGI-INPLDGTEKIAVDHNQM 121
Cdd:pfam07970  55 CRIKGTLEVNKVAGNFHIAPGRSFQQGGMHVHdlSPYLKLPDKFNFSHTIHHLSFGPDIPGEkVNPLDGTKVQTDTGNYM 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418655 122 FQYFITVVPTKLHTYKISA-DTHQFSVTERERIINHAAGSH---GVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGII 197
Cdd:pfam07970 135 FQYFLKVVPTRYEFLDGKKiETNQYSVTSHERPLTGGRDEHgrgGLPGVFFNYDISPMKVINTEQRRSFSHFLTSVCAII 214

                         170
                  ....*....|
gi 1720418655 198 GGIFSTTGML 207
Cdd:pfam07970 215 GGVFTVASLI 224
 
Name Accession Description Interval E-value
COPIIcoated_ERV pfam07970
Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to ...
 45-207 2.84e-60

Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localization. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.


Pssm-ID: 462327  Cd Length: 225  Bit Score: 189.74  E-value: 2.84e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418655  45 CRIHGHLYVNKVAGNFHITVGKAIPHPRGHAH--LAALVNHDSYNFSHRIDHLSFGELVPGI-INPLDGTEKIAVDHNQM 121
Cdd:pfam07970  55 CRIKGTLEVNKVAGNFHIAPGRSFQQGGMHVHdlSPYLKLPDKFNFSHTIHHLSFGPDIPGEkVNPLDGTKVQTDTGNYM 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418655 122 FQYFITVVPTKLHTYKISA-DTHQFSVTERERIINHAAGSH---GVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGII 197
Cdd:pfam07970 135 FQYFLKVVPTRYEFLDGKKiETNQYSVTSHERPLTGGRDEHgrgGLPGVFFNYDISPMKVINTEQRRSFSHFLTSVCAII 214

                         170
                  ....*....|
gi 1720418655 198 GGIFSTTGML 207
Cdd:pfam07970 215 GGVFTVASLI 224
 
Name Accession Description Interval E-value
COPIIcoated_ERV pfam07970
Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to ...
 45-207 2.84e-60

Endoplasmic reticulum vesicle transporter; This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localization. All proteins identified biochemically as Erv41p-Erv46p interactors are localized to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi.


Pssm-ID: 462327  Cd Length: 225  Bit Score: 189.74  E-value: 2.84e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418655  45 CRIHGHLYVNKVAGNFHITVGKAIPHPRGHAH--LAALVNHDSYNFSHRIDHLSFGELVPGI-INPLDGTEKIAVDHNQM 121
Cdd:pfam07970  55 CRIKGTLEVNKVAGNFHIAPGRSFQQGGMHVHdlSPYLKLPDKFNFSHTIHHLSFGPDIPGEkVNPLDGTKVQTDTGNYM 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1720418655 122 FQYFITVVPTKLHTYKISA-DTHQFSVTERERIINHAAGSH---GVSGIFMKYDLSSLMVTVTEEHMPFWQFFVRLCGII 197
Cdd:pfam07970 135 FQYFLKVVPTRYEFLDGKKiETNQYSVTSHERPLTGGRDEHgrgGLPGVFFNYDISPMKVINTEQRRSFSHFLTSVCAII 214

                         170
                  ....*....|
gi 1720418655 198 GGIFSTTGML 207
Cdd:pfam07970 215 GGVFTVASLI 224
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH