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Conserved domains on  [gi|1728929573|ref|XP_030353881|]
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kelch-like protein 25 [Strigops habroptila]

Protein Classification

kelch-like protein; BTB/POZ domain-containing protein 16( domain architecture ID 13033158)

kelch-like protein may act as substrate adaptors for Cullin 3 ubiquitin ligases| BTB/POZ domain-containing protein 16 (BTBD16) is a BTB-domain-containing Kelch-like protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-151 5.49e-98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 294.23  E-value: 5.49e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  24 HKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEVLELLLD 103
Cdd:cd18254     1 HKPSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDSLHPEVLELLLD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1728929573 104 FAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18254    81 FAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 144-242 3.87e-65

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


:

Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 207.78  E-value: 3.87e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18514     1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                          90
                  ....*....|....*....
gi 1728929573 224 ERKAYLPELLRNVRLALLP 242
Cdd:cd18514    81 KRKDYLPELLRNVRLALLP 99
PHA03098 super family cl33709
kelch-like protein; Provisional
 39-566 1.22e-60

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 210.01  E-value: 1.22e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  39 LRKHCMFTdVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLREsldDEVNFHDSLHpeVLELLLDFAYSSRIIINEENAE 118
Cdd:PHA03098    6 LQKFCDES-IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNIDYD--SFNEVIKYIYTGKINITSNNVK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 119 SLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLIS 198
Cdd:PHA03098   80 DILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 199 SDELEIEDEEKVFKAVIQWVKYDLDERKAYLPELLRNVRLALLPSECLKeALACEDLIMVDerNKIVLDE----AIQCKK 274
Cdd:PHA03098  160 DDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIK-KLKRWKLRIKK--KKIVFNKrcikIIYSKK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 275 KILQNDGVvtspcaRPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKeFSACAIGCKVYITGGRGSENGV 354
Cdd:PHA03098  237 YNLNKILP------RSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNKNNLS 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 355 SKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGhtavagvfpASPSVSLKQVEKYDPICNKWTMVAPLRDGV 434
Cdd:PHA03098  310 VNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGG---------IYNSISLNTVESWKPGESKWREEPPLIFPR 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 435 SNAAVVSARLKLFVFGGTSIHRDMVSKVQCYDPAENRWMIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAY----R 510
Cdd:PHA03098  381 YNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYniveS 460

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1728929573 511 FDCEADQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
Cdd:PHA03098  461 YNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
 
Name Accession Description Interval E-value
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-151 5.49e-98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 294.23  E-value: 5.49e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  24 HKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEVLELLLD 103
Cdd:cd18254     1 HKPSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDSLHPEVLELLLD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1728929573 104 FAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18254    81 FAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 144-242 3.87e-65

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 207.78  E-value: 3.87e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18514     1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                          90
                  ....*....|....*....
gi 1728929573 224 ERKAYLPELLRNVRLALLP 242
Cdd:cd18514    81 KRKDYLPELLRNVRLALLP 99
PHA03098 PHA03098
kelch-like protein; Provisional
 39-566 1.22e-60

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 210.01  E-value: 1.22e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  39 LRKHCMFTdVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLREsldDEVNFHDSLHpeVLELLLDFAYSSRIIINEENAE 118
Cdd:PHA03098    6 LQKFCDES-IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNIDYD--SFNEVIKYIYTGKINITSNNVK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 119 SLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLIS 198
Cdd:PHA03098   80 DILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 199 SDELEIEDEEKVFKAVIQWVKYDLDERKAYLPELLRNVRLALLPSECLKeALACEDLIMVDerNKIVLDE----AIQCKK 274
Cdd:PHA03098  160 DDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIK-KLKRWKLRIKK--KKIVFNKrcikIIYSKK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 275 KILQNDGVvtspcaRPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKeFSACAIGCKVYITGGRGSENGV 354
Cdd:PHA03098  237 YNLNKILP------RSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNKNNLS 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 355 SKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGhtavagvfpASPSVSLKQVEKYDPICNKWTMVAPLRDGV 434
Cdd:PHA03098  310 VNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGG---------IYNSISLNTVESWKPGESKWREEPPLIFPR 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 435 SNAAVVSARLKLFVFGGTSIHRDMVSKVQCYDPAENRWMIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAY----R 510
Cdd:PHA03098  381 YNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYniveS 460

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1728929573 511 FDCEADQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
Cdd:PHA03098  461 YNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
322-583 1.77e-50

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 175.34  E-value: 1.77e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 322 PKADLPSPRKEFSACAIGCKVYITGGRgSENGVSKDVWVYDTVHEEWSKAAPM-LIARFGHGSAELENCLYVVGGHTAVA 400
Cdd:COG3055     5 SLPDLPTPRSEAAAALLDGKVYVAGGL-SGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGAN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 401 GVfpaspSVSLKQVEKYDPICNKWTMVAPLRDGVSNAAVVSARLKLFVFGGTSIHRDmVSKVQCYDPAENRWMIKAECPQ 480
Cdd:COG3055    84 PS-----STPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN-VAWVEVYDPATGTWTQLAPLPT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 481 P-WRYTAAAVLGSQIFIMGGDTEFTAasayrfdceADQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQrcKTLDCYD 559
Cdd:COG3055   158 PrDHLAAAVLPDGKILVIGGRNGSGF---------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS--DEVEAYD 226

                         250       260
                  ....*....|....*....|....
gi 1728929573 560 PTSDTWNCITTVPYSLIPTAFVST 583
Cdd:COG3055   227 PATNTWTALGELPTPRHGHAAVLT 250
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 149-251 1.34e-40

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 142.68  E-value: 1.34e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 149 CLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDERKAY 228
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 1728929573 229 LPELLRNVRLALLPSECLKEALA 251
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 149-248 8.25e-36

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 129.38  E-value: 8.25e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  149 CLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDERKAY 228
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 1728929573  229 LPELLRNVRLALLPSECLKE 248
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 36-144 3.48e-30

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 114.28  E-value: 3.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  36 LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRiIINEE 115
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-VSPEDFEALLEFMYTGK-LISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 1728929573 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNL 144
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 47-144 2.23e-26

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 103.15  E-value: 2.23e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573   47 DVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAGDM 126
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-VSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 1728929573  127 LQFHDVRDAAAEFLEKNL 144
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
Kelch smart00612
Kelch domain;
389-441 2.33e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 52.95  E-value: 2.33e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1728929573  389 CLYVVGGHtavagvfpaSPSVSLKQVEKYDPICNKWTMVAPLRDGVSNAAVVS 441
Cdd:smart00612   1 KIYVVGGF---------DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAV 44
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 329-374 6.51e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.84  E-value: 6.51e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1728929573 329 PRKEFSACAIGCKVYITGGRGSENGVSkDVWVYDTVHEEWSKAAPM 374
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLN-SVEVYDPETNTWSKLPSM 45
 
Name Accession Description Interval E-value
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-151 5.49e-98

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 294.23  E-value: 5.49e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  24 HKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEVLELLLD 103
Cdd:cd18254     1 HKPSHPDCVLTHLNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDSLHPEVLELLLD 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1728929573 104 FAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18254    81 FAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 128
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-152 4.40e-96

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 289.97  E-value: 4.40e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573   6 HENRKSRTSTGSMNILLFHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDD 85
Cdd:cd18267     1 HENRKSRASSGSMNIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDS 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1728929573  86 EVNFHDSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGM 152
Cdd:cd18267    81 EVNFHDSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 144-242 3.87e-65

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 207.78  E-value: 3.87e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18514     1 LHPSNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKYDLE 80

                          90
                  ....*....|....*....
gi 1728929573 224 ERKAYLPELLRNVRLALLP 242
Cdd:cd18514    81 KRKDYLPELLRNVRLALLP 99
PHA03098 PHA03098
kelch-like protein; Provisional
 39-566 1.22e-60

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 210.01  E-value: 1.22e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  39 LRKHCMFTdVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLREsldDEVNFHDSLHpeVLELLLDFAYSSRIIINEENAE 118
Cdd:PHA03098    6 LQKFCDES-IIIVNGGGIIKVHKIILSSSSEYFKKMFKNNFKE---NEINLNIDYD--SFNEVIKYIYTGKINITSNNVK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 119 SLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLIS 198
Cdd:PHA03098   80 DILSIANYLIIDFLINLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILS 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 199 SDELEIEDEEKVFKAVIQWVKYDLDERKAYLPELLRNVRLALLPSECLKeALACEDLIMVDerNKIVLDE----AIQCKK 274
Cdd:PHA03098  160 DDKLNVSSEDVVLEIIIKWLTSKKNNKYKDICLILKVLRITFLSEEGIK-KLKRWKLRIKK--KKIVFNKrcikIIYSKK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 275 KILQNDGVvtspcaRPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKeFSACAIGCKVYITGGRGSENGV 354
Cdd:PHA03098  237 YNLNKILP------RSSTFGSIIYIHITMSIFTYNYITNYSPLSEINTIIDIHYVYC-FGSVVLNNVIYFIGGMNKNNLS 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 355 SKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGhtavagvfpASPSVSLKQVEKYDPICNKWTMVAPLRDGV 434
Cdd:PHA03098  310 VNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGG---------IYNSISLNTVESWKPGESKWREEPPLIFPR 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 435 SNAAVVSARLKLFVFGGTSIHRDMVSKVQCYDPAENRWMIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTAASAY----R 510
Cdd:PHA03098  381 YNPCVVNVNNLIYVIGGISKNDELLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISYIDNIKVYniveS 460

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1728929573 511 FDCEADQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
Cdd:PHA03098  461 YNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWT 516
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 145-242 1.21e-54

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 180.39  E-value: 1.21e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 145 YPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDE 224
Cdd:cd18464     1 HPSNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWIRYDLPR 80

                          90
                  ....*....|....*...
gi 1728929573 225 RKAYLPELLRNVRLALLP 242
Cdd:cd18464    81 RHEVLPELLRSVRLALLP 98
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
322-583 1.77e-50

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 175.34  E-value: 1.77e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 322 PKADLPSPRKEFSACAIGCKVYITGGRgSENGVSKDVWVYDTVHEEWSKAAPM-LIARFGHGSAELENCLYVVGGHTAVA 400
Cdd:COG3055     5 SLPDLPTPRSEAAAALLDGKVYVAGGL-SGGSASNSFEVYDPATNTWSELAPLpGPPRHHAAAVAQDGKLYVFGGFTGAN 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 401 GVfpaspSVSLKQVEKYDPICNKWTMVAPLRDGVSNAAVVSARLKLFVFGGTSIHRDmVSKVQCYDPAENRWMIKAECPQ 480
Cdd:COG3055    84 PS-----STPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGN-VAWVEVYDPATGTWTQLAPLPT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 481 P-WRYTAAAVLGSQIFIMGGDTEFTAasayrfdceADQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQrcKTLDCYD 559
Cdd:COG3055   158 PrDHLAAAVLPDGKILVIGGRNGSGF---------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS--DEVEAYD 226

                         250       260
                  ....*....|....*....|....
gi 1728929573 560 PTSDTWNCITTVPYSLIPTAFVST 583
Cdd:COG3055   227 PATNTWTALGELPTPRHGHAAVLT 250
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 145-242 1.60e-48

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 163.99  E-value: 1.60e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 145 YPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDE 224
Cdd:cd18515     1 HPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWVNYDLKK 80

                          90
                  ....*....|....*...
gi 1728929573 225 RKAYLPELLRNVRLALLP 242
Cdd:cd18515    81 RHCYLSELLQTVRLALLP 98
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-149 5.01e-44

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 152.62  E-value: 5.01e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  26 ASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFA 105
Cdd:cd18250     2 PAHALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHG-VSAEILGLLLDFS 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1728929573 106 YSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNC 149
Cdd:cd18250    81 YTGRVTVTQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
296-545 3.61e-41

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 150.31  E-value: 3.61e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 296 TLLILGGQTF--MCDKIYQVDHKAKEIIPKADLPSPRKEFSACA-IGCKVYITGGRGSENG---VSKDVWVYDTVHEEWS 369
Cdd:COG3055    24 KVYVAGGLSGgsASNSFEVYDPATNTWSELAPLPGPPRHHAAAVaQDGKLYVFGGFTGANPsstPLNDVYVYDPATNTWT 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 370 KAAPMLIARFGHGSAELENCLYVVGGHTavagvfpasPSVSLKQVEKYDPICNKWTMVAPL---RDGVSnAAVVSARlKL 446
Cdd:COG3055   104 KLAPMPTPRGGATALLLDGKIYVVGGWD---------DGGNVAWVEVYDPATGTWTQLAPLptpRDHLA-AAVLPDG-KI 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 447 FVFGGTSihrdmvskvqcYDPAENRWMIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTaASAYRFDCEADQWTRIGDMTA 526
Cdd:COG3055   173 LVIGGRN-----------GSGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFS-DEVEAYDPATNTWTALGELPT 240

                         250
                  ....*....|....*....
gi 1728929573 527 KRMSCHALASGNKLYVVGG 545
Cdd:COG3055   241 PRHGHAAVLTDGKVYVIGG 259
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 149-251 1.34e-40

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 142.68  E-value: 1.34e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 149 CLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDERKAY 228
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVKHDVERRKKH 80

                          90       100
                  ....*....|....*....|...
gi 1728929573 229 LPELLRNVRLALLPSECLKEALA 251
Cdd:pfam07707  81 LPELLSAVRLPLLSPQYLLNLVE 103
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-151 1.42e-39

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 140.62  E-value: 1.42e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  26 ASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHdSLHPEVLELLLDFA 105
Cdd:cd18256     1 DKHASLILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGGMSESSKDVVQIH-GVEPDIFHILLDFI 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1728929573 106 YSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18256    80 YTGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCIG 125
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-151 1.62e-38

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 138.42  E-value: 1.62e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  21 LLFHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLEL 100
Cdd:cd18259     8 LDFCLPSHPQSILDGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKD-VDPAVMES 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1728929573 101 LLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18259    87 LIDFAYTGKLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCLG 137
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 149-248 8.25e-36

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 129.38  E-value: 8.25e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  149 CLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDERKAY 228
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVKHDPEKRREH 80

                           90       100
                   ....*....|....*....|
gi 1728929573  229 LPELLRNVRLALLPSECLKE 248
Cdd:smart00875  81 LPELLEHVRLPLLSPDYLLE 100
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-151 3.43e-35

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 128.56  E-value: 3.43e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  36 LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEE 115
Cdd:cd18238     6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKD-IDEEAVELLVDFAYTGKLTLTVD 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1728929573 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18238    85 NVQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-152 1.78e-34

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 126.82  E-value: 1.78e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  31 CVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHdSLHPEVLELLLDFAYSSRI 110
Cdd:cd18268     9 ELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQAKVDLK-GIDSDVLDQIVDYVYTGEI 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1728929573 111 IINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGM 152
Cdd:cd18268    88 LITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 1.35e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 124.18  E-value: 1.35e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFhDSLHPEVLELLLDFAYS 107
Cdd:cd18253     1 HSESILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEI-NGILAEAMDCFLQYVYT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNC 149
Cdd:cd18253    80 GKVKITTENVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-151 6.57e-33

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 122.57  E-value: 6.57e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPeVLELLLDFAYS 107
Cdd:cd18265     6 HAERILQVLNAYRRSGTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQKVSAA-AMEVLLDYMYG 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18265    85 GGLRIQEDNVESVLEASDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-149 3.75e-32

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 120.24  E-value: 3.75e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  27 SHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHdSLHPEVLELLLDFAY 106
Cdd:cd18242     3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGKSEVELQ-GLTASTMEILLDFVY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1728929573 107 SSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNC 149
Cdd:cd18242    82 TETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-150 1.03e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 115.54  E-value: 1.03e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  46 TDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAGD 125
Cdd:cd18234     2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATEEEIKLKD-VDPDALWTLVQYCYTGRLELKEDNVESLLATAC 80

                          90       100
                  ....*....|....*....|....*
gi 1728929573 126 MLQFHDVRDAAAEFLEKNLYPSNCL 150
Cdd:cd18234    81 LLQLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-127 2.51e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 113.80  E-value: 2.51e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  45 FTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAG 124
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKESSSSEIELDD-VSPEAFEALLDYIYTGELELSEENVEELLAAA 79


                  ...
gi 1728929573 125 DML 127
Cdd:cd18186    80 DKL 82
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-153 3.40e-30

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 115.31  E-value: 3.40e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  26 ASHPDCVLSHLNTLRKHCMFTDVTL--------WAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEV 97
Cdd:cd18273     7 AAHARALLAQLKSFYDARLLTDVTIevngpgsgPGSGRLFPCNRNVLAAASPYFKSMFTGGLYESKQETVTIHD-VDSES 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1728929573  98 LELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGMM 153
Cdd:cd18273    86 MALIIDYCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGIL 141
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 36-144 3.48e-30

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 114.28  E-value: 3.48e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  36 LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRiIINEE 115
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITLDD-VSPEDFEALLEFMYTGK-LISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 1728929573 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNL 144
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 144-256 1.24e-29

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 112.71  E-value: 1.24e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18445     1 LHPSNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNHDPE 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1728929573 224 ERKAYLPELLRNVRLALLPSECLKEALACEDLI 256
Cdd:cd18445    81 NRKEHLAELLEHVRLPLLSPEYLVQRVEEEELI 113
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-146 2.34e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 112.52  E-value: 2.34e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  36 LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEE 115
Cdd:cd18235    12 MNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGDLSESRANRVTLQD-VDGKALLLLIDYVYTAEIQVTEE 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1728929573 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLYP 146
Cdd:cd18235    91 NVQVLLPAANLLQLTDVRDACCDFLQSQLHP 121
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-151 5.51e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 111.43  E-value: 5.51e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  26 ASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFA 105
Cdd:cd18237     2 AKLLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKD-AEPDIIELLVEFA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1728929573 106 YSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18237    81 YTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCLG 126
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-142 6.07e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 110.83  E-value: 6.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  29 PDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSS 108
Cdd:cd18247     3 PSSGFPVMEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQG-IEPSALEALINFAYSG 81

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1728929573 109 RIIINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Cdd:cd18247    82 RIAIDTSNVQSLLVGASFLQLQSVKDACCEFLKE 115
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-151 6.30e-29

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 111.39  E-value: 6.30e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYS 107
Cdd:cd18249     6 HPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTGELAESRQTEVTIRD-IDERAMELLIDFAYT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18249    85 SQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLKRQLDPSNCLG 128
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 144-241 1.03e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 110.09  E-value: 1.03e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18457     1 LHPNNCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWVKYDRE 80

                          90
                  ....*....|....*...
gi 1728929573 224 ERKAYLPELLRNVRLALL 241
Cdd:cd18457    81 NREEYLPELLSKVRLPLL 98
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 144-263 1.04e-28

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 110.95  E-value: 1.04e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18452     1 LDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWVKHDKE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1728929573 224 ERKAYLPELLRNVRLALLP---------SECL-KEALACEDLimVDERNK 263
Cdd:cd18452    81 EREDYLPELLQYVRLPLLSpryitdvvdAEPLiRCSLECRDL--VDEAKK 128
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
424-572 1.45e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 115.25  E-value: 1.45e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 424 WTMVAPLRDGVSNAAVVSARLKLFVFGGTSiHRDMVSKVQCYDPAENRWMIKAECPQPWR-YTAAAVLGSQIFIMGGDTE 502
Cdd:COG3055     3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLS-GGSASNSFEVYDPATNTWSELAPLPGPPRhHAAAVAQDGKLYVFGGFTG 81

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1728929573 503 FTA-----ASAYRFDCEADQWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVP 572
Cdd:COG3055    82 ANPsstplNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLP 156
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-144 3.12e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 109.39  E-value: 3.12e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  27 SHPDCVLSHLNTLRKHCMFTDVTLWAGNR----SFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLL 102
Cdd:cd18248     3 DHTKEAFQIMNELRLSQQLCDVTLKVKYQdpkeEFMAHKVVLASSSPYFKAMFTSGLRECGMEVVPIEG-VHPCVMSRLI 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1728929573 103 DFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNL 144
Cdd:cd18248    82 EFAYTASISVGEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-151 4.54e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 109.17  E-value: 4.54e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  31 CVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHdSLHPEVLELLLDFAYSSRI 110
Cdd:cd18236    10 VLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEEKIIIK-GVDAETMQILLDYTYTSKV 88

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1728929573 111 IINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18236    89 LITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENCVG 129
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 144-241 7.87e-27

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 104.43  E-value: 7.87e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18459     2 LDPSNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYNIQ 81

                          90
                  ....*....|....*...
gi 1728929573 224 ERKAYLPELLRNVRLALL 241
Cdd:cd18459    82 ERRPHLPQVLQHVRLPLL 99
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 47-144 2.23e-26

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 103.15  E-value: 2.23e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573   47 DVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAGDM 126
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-VSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 1728929573  127 LQFHDVRDAAAEFLEKNL 144
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-151 2.60e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 104.14  E-value: 2.60e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  26 ASHPDCVLSHLNTLRKHCMFTDVTLWAGN-RSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFhDSLHPEVLELLLDF 104
Cdd:cd18252     2 SSHPADFLDAFRTFYLDGLFTDITLQCASgQIFHCHKAALAACSSYFKVMFTADMKEKSNNVIKL-SGIDHDILEALVNY 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1728929573 105 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18252    81 VYTSQICITERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCLG 127
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 144-242 5.54e-26

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 102.41  E-value: 5.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18444     2 LHPSNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKHDLP 81

                          90
                  ....*....|....*....
gi 1728929573 224 ERKAYLPELLRNVRLALLP 242
Cdd:cd18444    82 ERKKHLAKLLALIRLPLLT 100
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-146 2.75e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 100.69  E-value: 2.75e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHdSLHPEVLELLLDFAYS 107
Cdd:cd18257     1 HSEQLLQGLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQ-CIDETALQAIVEYAYT 79

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYP 146
Cdd:cd18257    80 GTVFISQATVESLLPAANLLQIKLVLKECCDFLESQLDP 118
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 144-271 3.08e-25

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 100.91  E-value: 3.08e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18513     1 LHPTNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKYDKE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1728929573 224 ERKAYLPELLRNVRLALLPSECLKEALACEDLIMVDERNKIVLDEAIQ 271
Cdd:cd18513    81 ARLEHMAKLMEHVRLPLLPRDYLVQTVEEEALIKNNNTCKDFLIEAMK 128
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-152 4.55e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 100.50  E-value: 4.55e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  27 SHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFhDSLHPEVLELLLDFAY 106
Cdd:cd18336     1 NHAEQTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKQEEIKM-EGVDPDALKALVHYAY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1728929573 107 SSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGM 152
Cdd:cd18336    80 TGVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-151 6.85e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 99.64  E-value: 6.85e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglreSLDDEVNFH---DSLHPEVLELLLDF 104
Cdd:cd18306     1 HPESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSS----DSDGESILTvklDGLDPDAVEVLVNY 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1728929573 105 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18306    77 AYTSRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLTPQNCIG 123
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-149 6.89e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 99.71  E-value: 6.89e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  36 LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEE 115
Cdd:cd18240     8 FNELRLEGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEKKVYKIPG-VSPEMMELIIEYAYTRTVPITAE 86

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1728929573 116 NAESLLEAGDmlQFH--DVRDAAAEFLEKNLYPSNC 149
Cdd:cd18240    87 NVEELLPAAD--QFNimGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-149 1.07e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 99.01  E-value: 1.07e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFhDSLHPEVLELLLDFAYS 107
Cdd:cd18255     1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGGMRESSQDEIEL-KGVSAKGLKHILDFAYT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNC 149
Cdd:cd18255    80 SELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 144-271 1.61e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 98.95  E-value: 1.61e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18512     1 LHPTNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNHDKE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1728929573 224 ERKAYLPELLRNVRLALLPSECLKEALACEDLIMVDERNKIVLDEAIQ 271
Cdd:cd18512    81 VRQEHMAHLMEHVRLPLLSREYLVQRVEEETLVKNSSACKDYLIEAMK 128
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 144-238 4.36e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 96.73  E-value: 4.36e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELeIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18476     1 LTPSNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWIRHDPK 79

                          90
                  ....*....|....*
gi 1728929573 224 ERKAYLPELLRNVRL 238
Cdd:cd18476    80 ARKGYIHDLFKKVRL 94
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 146-243 4.68e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 96.71  E-value: 4.68e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 146 PSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDER 225
Cdd:cd18468     2 PSNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKWLKKDPKNR 81

                          90
                  ....*....|....*....
gi 1728929573 226 KAYLPELLRNVRLALL-PS 243
Cdd:cd18468    82 KQHIAELLAVVRLPFIhPS 100
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-152 6.65e-24

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 97.37  E-value: 6.65e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  26 ASHPDCVLSHLNTLRKHCMFTDVTLWAGN-RSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHdSLHPEVLELLLDF 104
Cdd:cd18274     3 PLHACSILQQLKAMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIV-GVEAESMHLVLDY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1728929573 105 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGM 152
Cdd:cd18274    82 AYTSRVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-150 3.13e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 95.55  E-value: 3.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  36 LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEE 115
Cdd:cd18269    18 LKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSDLEESKKKEVVLED-VDPDVMGMILKYLYTSEIDLNDQ 96

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1728929573 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 150
Cdd:cd18269    97 NVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCL 131
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 144-248 3.76e-23

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 94.32  E-value: 3.76e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18509     2 LHPSNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWVKYDMQ 81

                          90       100
                  ....*....|....*....|....*
gi 1728929573 224 ERKAYLPELLRNVRLALLPSECLKE 248
Cdd:cd18509    82 RRCSDLSMLLAYIRLPLLPPQLLAD 106
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-152 2.47e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 92.98  E-value: 2.47e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  36 LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEE 115
Cdd:cd18340    18 LKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLSDLEESKKREIVLED-VDPDVMGKILHYIYTSEIEITEQ 96

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1728929573 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGM 152
Cdd:cd18340    97 NVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAI 133
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-152 2.68e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 92.56  E-value: 2.68e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  25 KASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDF 104
Cdd:cd18276     1 RQKHSLTLLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFTCGLMECSQREVVLHD-ITAESVSIILNY 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1728929573 105 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGM 152
Cdd:cd18276    80 MYSSDLHLTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-152 3.52e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 92.43  E-value: 3.52e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  23 FHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFhDSLHPEVLELLL 102
Cdd:cd18337     1 FQALNHAEQTFKKMENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKQEEIKM-EGVEPNALWALV 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1728929573 103 DFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGM 152
Cdd:cd18337    80 QYAYTGRLELKEDNIECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 143-233 8.69e-22

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 90.05  E-value: 8.69e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 143 NLYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDL 222
Cdd:cd18458     1 QLDPSNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRWVKYDE 80

                          90
                  ....*....|.
gi 1728929573 223 DERKAYLPELL 233
Cdd:cd18458    81 ENRRQYLEALL 91
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 33-141 1.23e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 90.09  E-value: 1.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  33 LSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNF-HDSLHPEVLELLLDFAYSSRII 111
Cdd:cd18245     2 LRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDGSTYKIeLEGISVEVMEEILDYIYTGQIK 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1728929573 112 INEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18245    82 LSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-150 3.37e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 89.64  E-value: 3.37e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  22 LFHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHdSLHPEVLELL 101
Cdd:cd18261     5 LCQSKSHKDAVLAALNQQRNDGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFSLCMVESEADEVNLH-GVTSLGLKQA 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1728929573 102 LDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 150
Cdd:cd18261    84 LDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQELNSFNYL 132
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-151 3.53e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 89.26  E-value: 3.53e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  29 PDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDD---EVNFHDsLHPEVLELLLDFA 105
Cdd:cd18258     1 PKEMLKELNQQRRAKEFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGGGeklELTMSN-INADVLELLLEFV 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1728929573 106 YSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLG 151
Cdd:cd18258    80 YTGSLIIDSANAKTLLEAANKFQFHTFCKVCVSFLEKQLTASNCLG 125
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 146-246 4.12e-21

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 88.30  E-value: 4.12e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 146 PSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDER 225
Cdd:cd18466     3 PANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWILKDVGKR 82

                          90       100
                  ....*....|....*....|.
gi 1728929573 226 KAYLPELLRNVRLALLPSECL 246
Cdd:cd18466    83 KKHVVEVLEPVRFPLLPPQRL 103
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-146 5.54e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 89.32  E-value: 5.54e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  36 LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEE 115
Cdd:cd18246    30 MNRMRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHVTLHD-IDPQALEQLVQYAYTAEIVVGEG 108

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1728929573 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLYP 146
Cdd:cd18246   109 NVQTLLPAASLLQLNGVRDACCKFLLSQLDP 139
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 144-241 8.50e-21

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 87.52  E-value: 8.50e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18446     1 LHPENCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWVRYKES 80

                          90
                  ....*....|....*...
gi 1728929573 224 ERKAYLPELLRNVRLALL 241
Cdd:cd18446    81 ERLPLLPRVLENVRLPLL 98
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-150 1.02e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 88.35  E-value: 1.02e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  27 SHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAY 106
Cdd:cd18271     6 CHGQQILSVLQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFEVNMKERDDGSVTISN-LSPKAVKAFLDYAY 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1728929573 107 SSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 150
Cdd:cd18271    85 TGKAEITDDNVEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-146 1.15e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 87.85  E-value: 1.15e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  36 LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEE 115
Cdd:cd18339    12 MNELRSKQLLCDVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDMSESKAKKIEIKD-VDGQTLSKLIDYIYTAEIEVTEE 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1728929573 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLYP 146
Cdd:cd18339    91 NVQVLLPAASLLQLMDVRQNCCDFLQSQLHP 121
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 144-241 1.53e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 86.59  E-value: 1.53e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18456     1 LDPSNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWVKHDVD 80

                          90
                  ....*....|....*...
gi 1728929573 224 ERKAYLPELLRNVRLALL 241
Cdd:cd18456    81 GRRQHVPRLMKCVRLPLL 98
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 146-245 2.06e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 86.35  E-value: 2.06e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 146 PSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDER 225
Cdd:cd18469     5 ATNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVGHDPQAR 84

                          90       100
                  ....*....|....*....|
gi 1728929573 226 KAYLPELLRNVRLALLPSEC 245
Cdd:cd18469    85 AAHLPELLSLVHLSLLTDQY 104
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 36-146 2.27e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 87.05  E-value: 2.27e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  36 LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEE 115
Cdd:cd18338    12 MNELRSQNLLCDVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKE-VDGWTLKMLIDYVYTAEIQVTEE 90

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1728929573 116 NAESLLEAGDMLQFHDVRDAAAEFLEKNLYP 146
Cdd:cd18338    91 NVQVLLPAAGLLQLQDVKKTCCEFLESQLHP 121
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 144-241 3.62e-20

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 85.77  E-value: 3.62e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18467     1 LDPGNCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKYDVQ 80

                          90
                  ....*....|....*...
gi 1728929573 224 ERKAYLPELLRNVRLALL 241
Cdd:cd18467    81 ERQKYLAQLLHCVRLPLL 98
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-153 3.99e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 86.59  E-value: 3.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  32 VLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRII 111
Cdd:cd18270    13 LLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRN-VDAATLQIIITYAYTGNLA 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1728929573 112 INEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGMM 153
Cdd:cd18270    92 INDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 144-248 1.88e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 83.81  E-value: 1.88e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18510     2 LHPSNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRHDLQ 81

                          90       100
                  ....*....|....*....|....*
gi 1728929573 224 ERKAYLPELLRNVRLALLPSECLKE 248
Cdd:cd18510    82 NRQKDLGMLLSYIRLPLLPPQLLAD 106
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 144-239 2.53e-19

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 83.12  E-value: 2.53e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18448     2 LHPSNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWVKHDPQ 81

                          90
                  ....*....|....*.
gi 1728929573 224 ERKAYLPELLRNVRLA 239
Cdd:cd18448    82 HRKRHLDDLLSQVRLP 97
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-149 4.82e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 83.69  E-value: 4.82e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  18 MNILLFHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHdSLHPEV 97
Cdd:cd18264     1 MSYFLAYSKSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKARVIHLP-VVSAAG 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1728929573  98 LELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNC 149
Cdd:cd18264    80 LQRVLDFIYTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-150 4.99e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 83.40  E-value: 4.99e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  21 LLFHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEvLEL 100
Cdd:cd18266     1 KVYRWADHSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIG-LKA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1728929573 101 LLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 150
Cdd:cd18266    80 VIDFLYSSELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYL 129
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-152 1.11e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 82.40  E-value: 1.11e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFhDSLHPEVLELLLDFAYS 107
Cdd:cd18335     2 HAEQTFRKMESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDVCEAKQEEIKM-EGIDPNALWDLVQFAYT 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGM 152
Cdd:cd18335    81 GCLELKEDTIENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-152 2.80e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 81.43  E-value: 2.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  45 FTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFhDSLHPEVLELLLDFAYSSRIIINEENAESLLEAG 124
Cdd:cd18341    27 FVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEESEEKKKEVVL-DNVDPNIMDMILKYLYSAEIDLNDGNVQDIFALA 105

                          90       100
                  ....*....|....*....|....*...
gi 1728929573 125 DMLQFHDVRDAAAEFLEKNLYPSNCLGM 152
Cdd:cd18341   106 SRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-149 3.89e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 80.62  E-value: 3.89e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  23 FHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRS--FPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHdSLHPEVLEL 100
Cdd:cd18239     1 FTSNTHSSVVLQGFDQLRGEGLLCDVTLVPGDGDetFPVHRAMMASASDYFKAMFTGGMKEQELMCIKLH-GVSKIGLKN 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1728929573 101 LLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNC 149
Cdd:cd18239    80 IIDFIYTAKLSLNMDNLQDTLEAASFLQILPVLDFCKVLLISGVTLENC 128
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 144-220 5.26e-18

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 78.59  E-value: 5.26e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKY 220
Cdd:cd18463     2 LDPCNCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVYH 78
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 144-248 1.40e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 78.57  E-value: 1.40e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18511     2 LHPSNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWVRHDVE 81

                          90       100
                  ....*....|....*....|....*
gi 1728929573 224 ERKAYLPELLRNVRLALLPSECLKE 248
Cdd:cd18511    82 QRRKDLSKLLAYIRLPLLAPQFLAD 106
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 148-238 3.76e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 77.02  E-value: 3.76e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 148 NCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDERKA 227
Cdd:cd18479     5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQ 84

                          90
                  ....*....|.
gi 1728929573 228 YLPELLRNVRL 238
Cdd:cd18479    85 YLSSVLSQIRI 95
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 144-221 4.09e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 76.11  E-value: 4.09e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHK-SEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYD 221
Cdd:cd18450     1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKdSEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKWIDHD 79
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-132 4.21e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 77.56  E-value: 4.21e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  26 ASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEVLELLLDFA 105
Cdd:cd18329     2 SSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATFDVFSPDTFTIILDFV 81

                          90       100
                  ....*....|....*....|....*..
gi 1728929573 106 YSSRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18329    82 YSGKLSLTSQNVIEVMSAASYLQMTDV 108
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 147-221 5.62e-17

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 75.52  E-value: 5.62e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1728929573 147 SNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYD 221
Cdd:cd18508     3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAWLKHD 77
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-143 1.11e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 76.54  E-value: 1.11e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  23 FHKASHPDCVLSHLNTLRKHC-MFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDD-EVNFHdSLHPEVLEL 100
Cdd:cd18207     4 YQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPrELEMH-TISSKVFGD 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1728929573 101 LLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18207    83 ILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIKQS 125
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-144 1.99e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 75.67  E-value: 1.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  27 SHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESL----DDEVNFHDSLHPEV--LEL 100
Cdd:cd18228     1 SHSQELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLvlvsPAGKCVLDLHHVTVtgFAP 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1728929573 101 LLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNL 144
Cdd:cd18228    81 LLEYAYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 147-242 2.00e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 74.79  E-value: 2.00e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 147 SNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDERK 226
Cdd:cd18516     4 SNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVGKDQEERT 83

                          90
                  ....*....|....*.
gi 1728929573 227 AYLPELLRNVRLALLP 242
Cdd:cd18516    84 KALPVLLESIRFRLMP 99
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-122 2.34e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 75.35  E-value: 2.34e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1728929573  45 FTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSlHPEVLELLLDFAYSSRIIINEENAESLLE 122
Cdd:cd18287    22 YSDVTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKDT-NAEAFKALLKYIYTGRLTLTDLKEDVLLD 98
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 144-238 3.44e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 74.45  E-value: 3.44e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18460     1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKADPK 80

                          90
                  ....*....|....*
gi 1728929573 224 ERKAYLPELLRNVRL 238
Cdd:cd18460    81 HRQHFWPELLQHVRL 95
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-149 3.54e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 75.28  E-value: 3.54e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  23 FHKASHPDCVLSHLNTLRKHCMFTDVTL---WAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHD-----SLH 94
Cdd:cd18241     1 FECSSHCSELSWRQNEQRKQGLFCDITLafgGAGGREFRAHRSVLAAATEYFTPLLSGQFSESRSGRVEMRKwssepGPD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1728929573  95 PEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNC 149
Cdd:cd18241    81 PDTVEAVIQYMYTGRIRVSTGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 144-242 4.85e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 73.72  E-value: 4.85e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18477     1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVREAKE 80

                          90
                  ....*....|....*....
gi 1728929573 224 ERKAYLPELLRNVRLALLP 242
Cdd:cd18477    81 NRQKALPTVFESIRFRLLP 99
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-141 4.99e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 74.88  E-value: 4.99e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFH------DSLHPEVLELL 101
Cdd:cd18327     8 HSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAGGGqdvcelDFVGPEALGAL 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1728929573 102 LDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18327    88 LEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-141 6.71e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 74.13  E-value: 6.71e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGlreSLDDEVNFH--DSLHPEVLELLLDFA 105
Cdd:cd18198     8 HSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSG---AVVDQQNVYeiDFVSPEALTALLEFA 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1728929573 106 YSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18198    85 YTATLTVSTANVGDILSAARLLEIPCVSHVCAEILD 120
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-141 9.90e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 73.82  E-value: 9.90e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLresLDDEVNFH--DSLHPEVLELLLDFA 105
Cdd:cd18326     8 HSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTSGA---VVDQQNVYeiDFVSAEALTALLDFA 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1728929573 106 YSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18326    85 YTATLTVSTSNVGDILSAARLLEIPAVSHVCADLLD 120
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-139 1.69e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 72.60  E-value: 1.69e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLdDEVNFHDSLHPEVLELLLDFAYS 107
Cdd:cd18215     2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNV-SVINLDPEIEPEGFRILLDFMYT 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEF 139
Cdd:cd18215    81 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-139 2.87e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 72.14  E-value: 2.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  24 HKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglRESLDDEVNFHDSLHPEVLELLLD 103
Cdd:cd18212     2 HSKTHKDTVLTNFEEQRKKDFLCDITLIVENVQFRAHKALLAASSEYFSMMFAD--EGEVGQSIYMLEGMVAETFGALLE 79

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1728929573 104 FAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEF 139
Cdd:cd18212    80 FIYTGCLQVGEKSLEQILATAQFLKVNDLVKAYSDY 115
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 48-127 3.46e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 70.77  E-value: 3.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  48 VTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFhDSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDML 127
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINL-RDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-125 3.46e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 72.18  E-value: 3.46e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  29 PDCVLS-HLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYS 107
Cdd:cd18279     1 PECRLAeDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND-VDPEVFKEMMRFIYT 79

                          90
                  ....*....|....*...
gi 1728929573 108 SRIIINEENAESLLEAGD 125
Cdd:cd18279    80 GKAPNLDKMADDLLAAAD 97
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 45-133 3.64e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 71.22  E-value: 3.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  45 FTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAG 124
Cdd:cd18314     6 FSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLED-VEPEIFETVLKYMYTGQVTLSEENVLDLLMLA 84


                  ....*....
gi 1728929573 125 DMLQFHDVR 133
Cdd:cd18314    85 SKYQVPDLE 93
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-140 3.77e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 72.16  E-value: 3.77e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  23 FHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEVLElLL 102
Cdd:cd18251     1 YRSVAHSQALLDGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFAGGLREMQQTEVLIHGVSYNAMCK-IL 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1728929573 103 DFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18251    80 DFIYTSELELSLDNVQETLTAACQLQIPEVIGFCCDFL 117
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 144-233 6.28e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 70.66  E-value: 6.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18483     1 LDPQNSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWFEHEQS 80

                          90
                  ....*....|
gi 1728929573 224 ERKAYLPELL 233
Cdd:cd18483    81 KREMHLPEIF 90
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-132 6.87e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 70.92  E-value: 6.87e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEVLELLLDFAYS 107
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                          90       100
                  ....*....|....*....|....*
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18199    81 GKLSLTSQNVIEVMSAASYLQMTDV 105
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 47-150 8.17e-15

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 71.00  E-value: 8.17e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  47 DVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHdSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDM 126
Cdd:cd18263    15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSGMKESTQSVVQLP-TIPAKDLRLLISFAYSGILHLSWENLFEATCTALQ 93

                          90       100
                  ....*....|....*....|....
gi 1728929573 127 LQFHDVRDAAAEFLEKNLYPSNCL 150
Cdd:cd18263    94 LQISGALALCLDFLQREISPARCL 117
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 147-225 1.56e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 68.89  E-value: 1.56e-14
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1728929573 147 SNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDER 225
Cdd:cd18480     4 SNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRWTKHDLEAR 82
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
294-418 1.75e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 74.04  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 294 GHTLLILGGQTFmcdkiyqvDHKAKEIIPKADLPSPRKEFSACAIGCKVYITGGrgsENGVSKDVWVYDTVHEEWSKAAP 373
Cdd:COG3055   169 DGKILVIGGRNG--------SGFSNTWTTLAPLPTARAGHAAAVLGGKILVFGG---ESGFSDEVEAYDPATNTWTALGE 237

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1728929573 374 MLIARFGHGSAELENCLYVVGGHTAvagvfPASPSVSLKQVEKYD 418
Cdd:COG3055   238 LPTPRHGHAAVLTDGKVYVIGGETK-----PGVRTPLVTSAEVYD 277
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 146-241 1.99e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 69.27  E-value: 1.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 146 PSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDER 225
Cdd:cd18455     2 AENCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRWVRHDPEER 81

                          90
                  ....*....|....*.
gi 1728929573 226 KAYLPELLRNVRLALL 241
Cdd:cd18455    82 KVHLKDLMSSCWRSGL 97
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 45-128 3.26e-14

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 67.96  E-value: 3.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  45 FTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESlDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAG 124
Cdd:cd18315     1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPDE-HPVIILPD-VPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78


                  ....
gi 1728929573 125 DMLQ 128
Cdd:cd18315    79 ELLQ 82
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-141 4.30e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 68.73  E-value: 4.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLdDEVNFHDSLHPEVLELLLDFAYS 107
Cdd:cd18332     2 HSSDVLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFSGRVGEGV-SVLTLPSGLEARGFQLLLDFMYT 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18332    81 SRLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-148 8.35e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 68.11  E-value: 8.35e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  29 PDCVLSH-LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYS 107
Cdd:cd18343     4 PECRLAEdLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKKNRVEIND-VDPEVFKEMMRFIYT 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSN 148
Cdd:cd18343    83 GKAPNLDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 46-144 1.17e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 67.67  E-value: 1.17e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  46 TDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRI-IINEENAESLLEAG 124
Cdd:cd18286    18 SDITIKVDGKTFKAHRCILCARSSYFAAMLSGSWAESNSSEITLTG-VSHAAVSFVLLFIYGGVLdLPDDVNLGELLSLA 96

                          90       100
                  ....*....|....*....|
gi 1728929573 125 DMLQFHDVRDAAAEFLEKNL 144
Cdd:cd18286    97 DMYGLDGLKDVVAYTLRRDY 116
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 144-242 1.21e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 67.10  E-value: 1.21e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLD 223
Cdd:cd18517     1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTDKE 80

                          90
                  ....*....|....*....
gi 1728929573 224 ERKAYLPELLRNVRLALLP 242
Cdd:cd18517    81 NRVKSLGEIFDCIRFRLMP 99
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-141 1.81e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 67.21  E-value: 1.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  27 SHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGlreSLDDEVNFH--DSLHPEVLELLLDF 104
Cdd:cd18328     7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAG---TLADQPYVYeiDFVTPEALSAILEF 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1728929573 105 AYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18328    84 AYTSTLTITTSNVKHILNAAQMLEIQCIINVCLEIMD 120
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 148-240 1.89e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 66.68  E-value: 1.89e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 148 NCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDERKA 227
Cdd:cd18462     5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVAHDVEKRIE 84

                          90
                  ....*....|...
gi 1728929573 228 YLPELLRNVRLAL 240
Cdd:cd18462    85 CAYDLLSSIKLDL 97
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-140 2.98e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 65.57  E-value: 2.98e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  47 DVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDdeVNFHDSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDM 126
Cdd:cd18955     3 DVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDLV--ITLPEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                          90
                  ....*....|....
gi 1728929573 127 LQFHDVRDAAAEFL 140
Cdd:cd18955    81 LGVHNIEKACFDFL 94
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-112 3.20e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 66.45  E-value: 3.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSN--GLRESLDDEVNFHDSLHPEVLEL----- 100
Cdd:cd18195     1 HAGALLLQLNEQRLRGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSplPLGAAAVAAAPGATQSPERVLELpgvka 80

                          90
                  ....*....|....*..
gi 1728929573 101 -----LLDFAYSSRIII 112
Cdd:cd18195    81 gvfsdVLNFIYSSRVAL 97
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-131 3.50e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 65.94  E-value: 3.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESlddeVNFHDSLhPEVLELLLDFAYS 107
Cdd:cd18232     1 HSVKVLQALNKQREEGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGS----VVLPESF-AEVFGLLLDFFYT 75

                          90       100
                  ....*....|....*....|....
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHD 131
Cdd:cd18232    76 GELALTRENRDRVLLAAKELRVPE 99
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-153 5.18e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 66.46  E-value: 5.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  44 MFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEA 123
Cdd:cd18272    31 LFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNRVIELKD-VSESVFQLLVDYIYHGTVKLRVEELQETYEV 109

                          90       100       110
                  ....*....|....*....|....*....|
gi 1728929573 124 GDMLQFHDVRDAAAEFLEKNLYPSNCLGMM 153
Cdd:cd18272   110 ADMYQLTALFEECSRFLARTVQVRNCLQVM 139
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 146-240 5.72e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 65.13  E-value: 5.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 146 PSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDER 225
Cdd:cd18485     3 ASNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVNHNRKSR 82

                          90
                  ....*....|....*
gi 1728929573 226 KAYLPELLRNVRLAL 240
Cdd:cd18485    83 VQHLVELLKQVRLEL 97
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-139 6.39e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 64.82  E-value: 6.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  45 FTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESlDDEVNFH---DSLHPEVLELLLDFAYSSRIIINEENAESLL 121
Cdd:cd18307     1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSNDMKA-TDELSITidcDYLSPETVEQLLDYFYTGKIVISEKNVEDLL 79

                          90
                  ....*....|....*...
gi 1728929573 122 EAGDMLQFHDVRDAAAEF 139
Cdd:cd18307    80 KGAKYFNIPRLKDHCVDF 97
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 146-199 9.05e-13

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 63.06  E-value: 9.05e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1728929573 146 PSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISS 199
Cdd:cd14733     2 PENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-140 1.05e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 65.09  E-value: 1.05e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  20 ILLFHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglreSLDDEVNFhdSLHPEV-- 97
Cdd:cd18277     2 VFAYESSVHSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVG----QADAELNI--TLPEEVtv 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1728929573  98 --LELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18277    76 kgFEPLIQFAYTAKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-148 1.11e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 64.87  E-value: 1.11e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  29 PDCVLSH-LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHpEVLELLLDFAYS 107
Cdd:cd18345     1 PECRLSDdLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITDVDH-EVMREMLRFIYT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSN 148
Cdd:cd18345    80 GKAPNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 42-127 1.82e-12

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 64.24  E-value: 1.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  42 HCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLD-----DEVNFHDsLHPEVLELLLDFAYSSRIIINEEN 116
Cdd:cd18296    14 ELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAESEEnngsiPVVTLHD-VSPEVFAIVLYYIYTDDTDLPPEN 92

                          90
                  ....*....|.
gi 1728929573 117 AESLLEAGDML 127
Cdd:cd18296    93 AYDVLYVADMY 103
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-140 5.39e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 63.04  E-value: 5.39e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  22 LFHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMF----SNGLRESLDDEVNFHdSLHPev 97
Cdd:cd18278     8 VYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALvgqtENDLVVSLPEEVTAR-GFGP-- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1728929573  98 lelLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18278    85 ---LLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-142 6.55e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 62.75  E-value: 6.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  32 VLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglreSLDDEVNFHDSLHPEVLELLLDFAYSSRII 111
Cdd:cd18290    14 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPAAVQPQSFQQILSFCYTGRLS 89

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1728929573 112 INEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Cdd:cd18290    90 MNVGDQFLLMYTAGFLQIQEIMEKGTEFFLK 120
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-135 1.03e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 62.16  E-value: 1.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  24 HKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFsngLRESLDDEVNFH-DSLHPEVLELLL 102
Cdd:cd18224     5 HSSDHPNNLLKELNKCRLSETMCDVTIVVGNRSFAAHKAVLACAAGYFQKLF---LSTELDVARTYVvDFITPANFEKVL 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1728929573 103 DFAYSSRIIINEENAESLLEAGDMLQFHDVRDA 135
Cdd:cd18224    82 SFIYTSELFTDLINVGVIYEVAEKLGMEDLLKA 114
PHA02790 PHA02790
Kelch-like protein; Provisional
 63-566 1.10e-11

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 67.38  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  63 VLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Cdd:PHA02790   39 ILKKLSPYFRTHLRQKYTKNKDPVTRVCLDLDIHSLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFILR 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 143 NLYPSNCLGMMLLSDAhqcrrlYELSWRMCLV-NFETVHKSE-------DFNNLSKDTLLDlisSDELEIEDEEKVFKAV 214
Cdd:PHA02790  119 DFRKEYCVECYMMGIE------YGLSNLLCHTkDFIAKHFLEleddiidNFDYLSMKLILE---SDELNVPDEDYVVDFV 189

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 215 IQWVKydldERKAYLPELLRNVRlallpseclkealacedlimvdernkivldeaiqckkkilqndGVVTSPCARPRKAG 294
Cdd:PHA02790  190 IKWYM----KRRNRLGNLLLLIK-------------------------------------------NVIRSNYLSPRGIN 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 295 HTLLILGgqtfmCDKIYQVDHKAKEII--PKADLPSPRKE----FSACA---IGCKVYITGGrGSENGVSKDVWVYDTVH 365
Cdd:PHA02790  223 NVKWILD-----CTKIFHCDKQPRKSYkyPFIEYPMNMDQiidiFHMCTsthVGEVVYLIGG-WMNNEIHNNAIAVNYIS 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 366 EEWSKAAPMLIARFGHGSAELENCLYVVGGhtavagvFPASPSVslkqvEKYDPICNKWTMVAPLRDGVSNAAVVSARLK 445
Cdd:PHA02790  297 NNWIPIPPMNSPRLYASGVPANNKLYVVGG-------LPNPTSV-----ERWFHGDAAWVNMPSLLKPRCNPAVASINNV 364

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 446 LFVFGGtsiHRDMVSKVQCYDPAENRWMIKAECPQPWRYTAAAVLGSQIFIMGGDTEFTaasayrfdCE-ADQWTRIGDM 524
Cdd:PHA02790  365 IYVIGG---HSETDTTTEYLLPNHDQWQFGPSTYYPHYKSCALVFGRRLFLVGRNAEFY--------CEsSNTWTLIDDP 433

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|..
gi 1728929573 525 TAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWN 566
Cdd:PHA02790  434 IYPRDNPELIIVDNKLLLIGGFYRGSYIDTIEVYNNRTYSWN 475
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-141 1.27e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 61.98  E-value: 1.27e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  30 DCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVnfhdSLHPEVLELLLDFAYSSR 109
Cdd:cd18222    10 NSVLSHLNQLRMQGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISV----IKNPTVFEQLLSFCYTGR 85

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1728929573 110 IIINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18222    86 ICLQLADIISYLTAASFLQMQHIIDKCTQILE 117
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-140 1.49e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 61.80  E-value: 1.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLdDEVNFHDSLHPEVLELLLDFAYS 107
Cdd:cd18331     7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNL-SVINLDPEINPEGFNILLDFMYT 85

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18331    86 SRLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 147-240 1.88e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 60.83  E-value: 1.88e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 147 SNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDERK 226
Cdd:cd18447     5 SNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRWLKYDEPNRQ 84

                          90
                  ....*....|....
gi 1728929573 227 AYLPELLRNVRLAL 240
Cdd:cd18447    85 PYMVDILAKVRFPL 98
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-144 2.12e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 61.61  E-value: 2.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  27 SHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEVLELLLDFAY 106
Cdd:cd18230     3 SHYRHLLRELNEQRQHGILCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVTHLDIVTAQGFKAIIDFMY 82

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1728929573 107 SSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNL 144
Cdd:cd18230    83 SAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAAL 120
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-132 5.03e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 59.94  E-value: 5.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  32 VLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEVLELLLDFAYSSRII 111
Cdd:cd18330     5 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLIHYIQDSGRHSTASLDIVTSEAFSIILDFLYSGKLD 84

                          90       100
                  ....*....|....*....|.
gi 1728929573 112 INEENAESLLEAGDMLQFHDV 132
Cdd:cd18330    85 LCSENVIEVMSAASYLQMTDV 105
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-127 5.11e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 59.80  E-value: 5.11e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglRESL-DDEVNFHDSLHPEVLELLLDFAY 106
Cdd:cd18223     1 HSDTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSS--QEIWiSSHVLELPDLKAEVFAEILNFIY 78

                          90       100
                  ....*....|....*....|..
gi 1728929573 107 SSRIIINE-ENAESLLEAGDML 127
Cdd:cd18223    79 SSKVVVKRqETVTDLVAAGKKL 100
PHA02713 PHA02713
hypothetical protein; Provisional
 32-448 1.82e-10

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 63.49  E-value: 1.82e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  32 VLSHLNTLRKHCMFTDVTLWAGN-RSFPCHRAVLAASSRYFEAMFSNGL-RESLDDEVNFHdSLHPEVLELLLDFAYSSR 109
Cdd:PHA02713   12 VVSNISNLLDDDILCDVIITIGDgEEIKAHKTILAAGSKYFRTLFTTPMiIRDLVTRVNLQ-MFDKDAVKNIVQYLYNRH 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 110 IiiNEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGMMllsdahqcRRLYELSW--------RMCLVNFETVHK 181
Cdd:PHA02713   91 I--SSMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMY--------HRLYEMSHipivkyikRMLMSNIPTLIT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 182 SEDFNNLSKDTLLDLISS-DELEIEDEEKVFKAVIQWVKYDLDERKAYL--------PELLRNVRLALLPSECLKEALAC 252
Cdd:PHA02713  161 TDAFKKTVFEILFDIISTnDNVYLYREGYKVTILLKWLEYNYITEEQLLcilscidiQNLDKKSRLLLYSNKTINMYPSC 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 253 EDLIMVDERNKIVLDEAI----------QCKKKIL-------QNDGVVTSPCARPRKAG----HTLLILGGQTF---MCD 308
Cdd:PHA02713  241 IQFLLDNKQNRNIIPRQLclvchdtkynVCNPCILvynintmEYSVISTIPNHIINYASaivdNEIIIAGGYNFnnpSLN 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 309 KIYQVDHKAKEIIPKADLPSPRKEFSACAIGCKVYITGGRGSENgVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELEN 388
Cdd:PHA02713  321 KVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTN-VERTIECYTMGDDKWKMLPDMPIALSSYGMCVLDQ 399

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1728929573 389 CLYVVGGHT---------AVAGVFPASPSVSLKQVEKYDPICNKWTMVAPLRDGVSNAAVVSARLKLFV 448
Cdd:PHA02713  400 YIYIIGGRTehidytsvhHMNSIDMEEDTHSSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYV 468
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-132 1.84e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 58.23  E-value: 1.84e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFsnglrESLDDEVNFHD--SLHPEVLELLLDFA 105
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQY-----KDTEDNIVFLDqsQVSADGFQKLLEFI 75

                          90       100
                  ....*....|....*....|....*..
gi 1728929573 106 YSSRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18217    76 YTGNLNLDSWNVAEIHQAASYLGMEEV 102
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-148 2.13e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 58.81  E-value: 2.13e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  29 PDCVLSH-LNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYS 107
Cdd:cd18344     6 PRHMLTDdLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEERLKNPIEIHD-LDPQVFKEMMGFIYT 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1728929573 108 SRI--IINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSN 148
Cdd:cd18344    85 GKAphLHSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 147-221 2.39e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 57.13  E-value: 2.39e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1728929573 147 SNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYD 221
Cdd:cd18474     4 NNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRWVDAD 78
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 144-218 2.65e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 56.63  E-value: 2.65e-10
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1728929573 144 LYPSNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWV 218
Cdd:cd18472     1 LSPANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-139 2.71e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 58.02  E-value: 2.71e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFsnglreslddeVNFHDSLHPEV-----LELLL 102
Cdd:cd18206     5 HSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLF-----------VDQKDVVHLDIsnaagLGQVL 73

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1728929573 103 DFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEF 139
Cdd:cd18206    74 EFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-143 2.97e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 58.05  E-value: 2.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  27 SHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglreslDDEVNFH-DSLHPEVLELLLDFA 105
Cdd:cd18334     3 NHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLH------DNLINLDtDMVNPTVFRQILDFI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1728929573 106 YSSRIIIN----EENAESLLEAGDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18334    77 YTGKLLTSdqpgEQNFNALLTAASYLQLHDLAALCRKKLKRN 118
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 28-127 3.19e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 57.22  E-value: 3.19e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFeamfsnglRESLDDEVNFHDSLHPEV----LELLLD 103
Cdd:cd18262     1 HPSQFFGEAQRLREQRLLLDETVSVGGRSYGVHSVILAAVSSLF--------RERLLGSNGPLPPLSLEVtpvgWEAVLT 72

                          90       100
                  ....*....|....*....|....
gi 1728929573 104 FAYSSRIIINEENAESLLEAGDML 127
Cdd:cd18262    73 FAYTGVLGRNPATVGDILVAAEAL 96
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-141 3.21e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 57.73  E-value: 3.21e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  23 FHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVnfhdSLHPEVLELLL 102
Cdd:cd18220     3 FDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISV----IKNPNVFEQLL 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1728929573 103 DFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18220    79 SFCYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-124 3.59e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 57.58  E-value: 3.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglRESLDDEVNFHDSLHPEVLELLLDFAYS 107
Cdd:cd18209     1 HAISLLSALNEERLKGQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTE--KENESQSVFQLDFCEPDAFENVLNYIYS 78

                          90
                  ....*....|....*..
gi 1728929573 108 SRIIINEENAESLLEAG 124
Cdd:cd18209    79 SSLFVEKSSLAAVQELG 95
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-134 3.66e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 57.52  E-value: 3.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  25 KASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglRESLDDEVNFHD-SLHPEVLELLLD 103
Cdd:cd18192     1 RPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFIN--HQHTTAQLNLSNmKISAECFDLILQ 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1728929573 104 FAYSSRIIINEENAESLLEAGDMLQFHDVRD 134
Cdd:cd18192    79 FMYLGKIMTAPSDFEQLKVAMNYLQLYYIPE 109
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 46-125 4.60e-10

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 57.49  E-value: 4.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  46 TDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFhDSLHPEVLELLLDFAYSSRIIINEENAESLLEAGD 125
Cdd:cd18352    14 SDVTFLVEGRRFYAHRIALLASSDAFRAMFDGGYREKEARDIEI-PNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAAD 92
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-143 5.66e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 57.26  E-value: 5.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  32 VLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYF--EAMFSNGLRESLDDEVNfhdslhPEVLELLLDFAYSSR 109
Cdd:cd18227    12 ILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLLKNSRRIVLPDVMN------PRVFENILLSCYTGR 85

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1728929573 110 IIINEENAESLLEAGDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18227    86 LVLPAPEIVSYLTAASFLQMWHVVDKCTELLEGN 119
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-132 6.59e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 56.76  E-value: 6.59e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  32 VLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVnfhdsLHPEVLELLLDFAYSSRII 111
Cdd:cd18225    10 LLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASV-----VSPEEFALLLEMVYTGKLP 84

                          90       100
                  ....*....|....*....|.
gi 1728929573 112 INEENAESLLEAGDMLQFHDV 132
Cdd:cd18225    85 PGKHNFTKIISVADSLQMFDV 105
BTB_POZ_ZBTB10 cd18201
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-144 6.69e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349510 [Multi-domain]  Cd Length: 122  Bit Score: 56.89  E-value: 6.69e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  32 VLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFH-DSLHPEVLELLLDFAYSSRI 110
Cdd:cd18201     8 LLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVTHlDVVAVQGFSVILDFMYSGNL 87

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1728929573 111 IINEENAESLLEAGDMLQFHDVRDAAAEFLEKNL 144
Cdd:cd18201    88 VLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDAL 121
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-139 9.77e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 56.14  E-value: 9.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  44 MFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSN-GLRESLDDEVNFHDSlhPE---VLELLLDFAYSSRIIINEENAES 119
Cdd:cd18292    16 ELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNdWWSESKQSEIELVED--PEcaaVFEKFLRYLYTGQISVNLETALP 93

                          90       100
                  ....*....|....*....|
gi 1728929573 120 LLEAGDMLQFHDVRDAAAEF 139
Cdd:cd18292    94 LLMLADKYNVTDLKQLCVDF 113
PLN02153 PLN02153
epithiospecifier protein
 337-529 1.26e-09

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 60.00  E-value: 1.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 337 AIGCKVYITGGRgSENGVSKDVWVYDTVHEEWS-------KAAPMliARFGHGSAELENCLYVVGGHTavAGVFPASPSv 409
Cdd:PLN02153   83 AVGTKLYIFGGR-DEKREFSDFYSYDTVKNEWTfltkldeEGGPE--ARTFHSMASDENHVYVFGGVS--KGGLMKTPE- 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 410 SLKQVEKYDPICNKWTMVAPLRD-----GVSNAAVVSARLKLfVFG-GTSI----HRDMVSK-VQCYDPAENRWM-IKAE 477
Cdd:PLN02153  157 RFRTIEAYNIADGKWVQLPDPGEnfekrGGAGFAVVQGKIWV-VYGfATSIlpggKSDYESNaVQFFDPASGKWTeVETT 235

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1728929573 478 CPQPWRYT--AAAVLGSQIFIMGGDT----------EFTAASAYRFDCEADQWTRIGDMTAKRM 529
Cdd:PLN02153  236 GAKPSARSvfAHAVVGKYIIIFGGEVwpdlkghlgpGTLSNEGYALDTETLVWEKLGECGEPAM 299
BTB_POZ_KLHL42 cd18319
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-141 1.32e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9) or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of katanin (KATNA1). KLHL42 is involved in microtubule dynamics throughout mitosis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349628 [Multi-domain]  Cd Length: 93  Bit Score: 55.26  E-value: 1.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  53 GNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHdSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQfhDV 132
Cdd:cd18319     9 EDRCYNVSKRKLIEQSDYFRALYRSGMRESGEEVVQLR-GLSAPGLELVLDFINTSKVHESQGDSTDTLEENELLE--DL 85


                  ....*....
gi 1728929573 133 RDAAAeFLE 141
Cdd:cd18319    86 VEAAS-FLQ 93
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-127 1.48e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 55.61  E-value: 1.48e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  26 ASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESlddEVNFhdsLHPEVLELLLDFA 105
Cdd:cd18219     2 TQYSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSVAGQVV---ELNF---IRADIFAEILNYI 75

                          90       100
                  ....*....|....*....|...
gi 1728929573 106 YSSRII-INEENAESLLEAGDML 127
Cdd:cd18219    76 YSSKIVrVRSDLLEELIKSGQLL 98
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-131 1.52e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 55.78  E-value: 1.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEvnfhDSLHPEVLELLLDFAYS 107
Cdd:cd18221     1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEI----EGVSNMAFRHLIEFTYT 76

                          90       100
                  ....*....|....*....|....*
gi 1728929573 108 SRIIIN-EENAESLLEAGDMLQFHD 131
Cdd:cd18221    77 AKLMVQgEEEANDVWKAAEYLQMQE 101
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-138 1.70e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 55.80  E-value: 1.70e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  46 TDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRII-INEENAESLLEAG 124
Cdd:cd18280    15 ADVTFNVDGEKFRAHKLVLAARSPVFRSMLFGPMREENEGEIVIED-VEPPVFKALLHFIYKDELPdDVEPAGSDSSSLD 93

                          90
                  ....*....|....
gi 1728929573 125 DMLQFHDVrdAAAE 138
Cdd:cd18280    94 TTMAQHLL--AAAD 105
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-140 1.75e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 55.70  E-value: 1.75e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  47 DVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGlRESLDDEVNFhDSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDM 126
Cdd:cd18231    18 DIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQN-KQLQRVELSL-EALTSQGLQQILNFIYTSKLLVNSCNVQDVLNAAAV 95

                          90
                  ....*....|....
gi 1728929573 127 LQFHDVRDAAAEFL 140
Cdd:cd18231    96 LQMNDIAASCQELI 109
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-146 1.80e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 55.82  E-value: 1.80e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRE------SLDDEVnfhdsLHPEVLELL 101
Cdd:cd18196     4 HFEQIFQQLNYQRLHGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTVAEGDqtmnmiQLDSEV-----VTAEAFAAL 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1728929573 102 LDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYP 146
Cdd:cd18196    79 IDMMYTSTLMLGESNVMDVLLAASHLHLNSVVKACKHYLTTRTLP 123
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 36-135 1.86e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 55.30  E-value: 1.86e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  36 LNTLRKHCMFTDVTLWAGNR-SFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNfhdslhPEVLELLLDFAYSSRIIINE 114
Cdd:cd18299     3 LRNLLHSPSCADVVFILQGGvRIFAHRIVLAAASSVFADLFLMMTVVTLDSDIT------PEAFRRVLEFLYTGVLDENE 76

                          90       100
                  ....*....|....*....|.
gi 1728929573 115 ENAESLLEAGDMLQFHDVRDA 135
Cdd:cd18299    77 DDLKELKDAAELLELFDLVMM 97
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-153 2.13e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 56.12  E-value: 2.13e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  19 NILLFHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFhDSLHPEVL 98
Cdd:cd18244     4 DVEVYNSSIHDTSVSAGFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADMRERDQDKIHL-KGLTATGF 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1728929573  99 ELLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCLGMM 153
Cdd:cd18244    83 SHVLQFMYYGTIELSMLTVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEIM 137
Kelch smart00612
Kelch domain;
389-441 2.33e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 52.95  E-value: 2.33e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1728929573  389 CLYVVGGHtavagvfpaSPSVSLKQVEKYDPICNKWTMVAPLRDGVSNAAVVS 441
Cdd:smart00612   1 KIYVVGGF---------DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAV 44
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 47-108 3.62e-09

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 54.22  E-value: 3.62e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1728929573  47 DVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVN--FH-DSLHPEVLELLLDFAYSS 108
Cdd:cd18301    20 DVVFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEDAVGCdvVHiEKVPPEIFEQLLQFIYTD 84
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 47-126 4.57e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 53.29  E-value: 4.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  47 DVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDS-LHPEVLELLLDFAYSSRIII-NEENAESLLEAG 124
Cdd:cd18190     1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENgISIEAMRAVIDFSVTGRLDLfSVENVHEVLELA 80


                  ..
gi 1728929573 125 DM 126
Cdd:cd18190    81 SK 82
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-148 4.97e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 54.66  E-value: 4.97e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  27 SHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSnglreslDDEVNFHDSLHPEvLELLLDFAY 106
Cdd:cd18243    14 SHSDNLLHGLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLFS-------INNLVLQGCSSIG-LRLVLEYLY 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1728929573 107 SSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSN 148
Cdd:cd18243    86 TANVTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-143 5.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 54.52  E-value: 5.19e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  27 SHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglreslDDEVNF-HDSLHPEVLELLLDFA 105
Cdd:cd18333     3 SHSRQLLLQLNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKSLVVH------DNLINLdHEMVSPGIFRLILDYI 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1728929573 106 YSSRIIINEENAE----SLLEAGDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18333    77 YTGRLSEGDPGSEqnlgAVLAAASYLQIPDLVALCKKKLKRN 118
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-148 5.85e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 54.34  E-value: 5.85e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  29 PDCVLS-HLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYS 107
Cdd:cd18342     5 PECRLAdELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEIND-VEPEVFKEMMCFIYT 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSN 148
Cdd:cd18342    84 GKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 124
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 329-374 6.51e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.84  E-value: 6.51e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1728929573 329 PRKEFSACAIGCKVYITGGRGSENGVSkDVWVYDTVHEEWSKAAPM 374
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLN-SVEVYDPETNTWSKLPSM 45
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 158-218 8.20e-09

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 52.58  E-value: 8.20e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1728929573 158 AHQCRRLyeLSWrmclvNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWV 218
Cdd:cd18493    21 AEACLEF--IAW-----NFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-141 8.92e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 53.36  E-value: 8.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDdevNFH-DSLHPEVLELLLDFAY 106
Cdd:cd18233     1 HSCHLLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKND---VFHlDIKNVGGIGQILDFMY 77

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1728929573 107 SSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLE 141
Cdd:cd18233    78 TSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 528-572 9.09e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 51.46  E-value: 9.09e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1728929573 528 RMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVP 572
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-146 1.17e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 53.88  E-value: 1.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  32 VLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDdevnFHDSLHPEVLELLLDFAYSSRII 111
Cdd:cd18289    16 VLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFE----LPATVPPACFQQILSFCYTGKLT 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1728929573 112 INEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYP 146
Cdd:cd18289    92 MAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSP 126
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-148 1.25e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 53.59  E-value: 1.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  46 TDVTLWAGN----RSFPCHRAVLAASSRYFEAMFSNGLRESlDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLL 121
Cdd:cd18281    23 SDVHFIVGKgdneQRIPAHKFVLSIGSAVFDAMFNGGMATT-SAEIELPD-VEPAAFLALLRFLYSDEVQIGPETVMTTL 100

                          90       100
                  ....*....|....*....|....*..
gi 1728929573 122 EAGDMLQFHDVRDAAAEFLEKNLYPSN 148
Cdd:cd18281   101 YTAKKYAVPALESACVEFLKKNLSSDN 127
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-132 1.54e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 53.29  E-value: 1.54e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglRESLDDEVNFH-DSLHPEVLELLLDFAY 106
Cdd:cd18194     6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRD--RLDKRDLVRLNsDIVTAPAFGLLLDFMY 83

                          90       100
                  ....*....|....*....|....*.
gi 1728929573 107 SSRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18194    84 EGRLALRDLPVEDVLAAASYLHMYDI 109
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 44-128 1.59e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 52.63  E-value: 1.59e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  44 MFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEEN-AESLLE 122
Cdd:cd18300     8 LFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELPG-VSKETFLALLEYLYTDQAPILEDGdCVGLIV 86


                  ....*.
gi 1728929573 123 AGDMLQ 128
Cdd:cd18300    87 LANRLC 92
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-150 1.81e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 52.89  E-value: 1.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSnglRESLDDEVNFHDsLHPEVLELLLDFAYS 107
Cdd:cd18260     1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILK---KDPSLQRVELND-ISPLGLATVITYAYT 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 150
Cdd:cd18260    77 GKLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-140 1.99e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 52.63  E-value: 1.99e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  44 MFTDVTLWAGNRSFP--CHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEVLELLLDFAYSSRIIINEENAESLL 121
Cdd:cd18294    13 EFSDVKFLVGPERQEifAHKCILAARCEVFRAMFLTGPQKESTQSPLVLSDIEPEVFRAVLEFIYTNCVTLSNHTVIEVL 92

                          90
                  ....*....|....*....
gi 1728929573 122 EAGDMLQFHDVRDAAAEFL 140
Cdd:cd18294    93 AAAVEYGLDELRKLCERFI 111
Kelch smart00612
Kelch domain;
539-585 2.24e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 50.25  E-value: 2.24e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1728929573  539 KLYVVGGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVSTWK 585
Cdd:smart00612   1 KIYVVGGFDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 27-132 2.68e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 52.15  E-value: 2.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  27 SHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglreslDDEVNF-HDSLHPEVLELLLDFA 105
Cdd:cd18216     2 SHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLH------DNLIHLdQDMVSPTVFQQILDFI 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 1728929573 106 YSSRII---INEENAESLLEAGDMLQFHDV 132
Cdd:cd18216    76 YTGKLLdslFEEPNLSEVLAAANYLQLPDL 105
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-143 2.86e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 52.28  E-value: 2.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  47 DVTLWAGNRSFPCHRAVLAASSrYFEAMFSNGLRESLDDEVNFH---DSLHPEVLELLLDFAYSSRIIINEENAESLLEA 123
Cdd:cd18305    17 DITICALGREWKLHKIYLCQSG-YFASMFSGSWKESKETVINLEipdDNITVEALNVVFGSLYRDEIEIKPSRVVSILAA 95

                          90       100
                  ....*....|....*....|
gi 1728929573 124 GDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18305    96 ATLLQLDGLIQQCSEVMKET 115
PLN02193 PLN02193
nitrile-specifier protein
 337-521 3.21e-08

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 56.12  E-value: 3.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 337 AIGCKVYITGGRGSE---NGVskdvWVYDTVHEEWSKAAPML---IARFGHGSAELENCLYVVGGHTAVAgvfpaspsvS 410
Cdd:PLN02193  226 SIGSTLYVFGGRDASrqyNGF----YSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATA---------R 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 411 LKQVEKYDPICNKWTMVAPLRDGVS---NAAVVSARLKLFV---FGGTSihrdmVSKVQCYDPAENRWM---IKAECPQP 481
Cdd:PLN02193  293 LKTLDSYNIVDKKWFHCSTPGDSFSirgGAGLEVVQGKVWVvygFNGCE-----VDDVHYYDPVQDKWTqveTFGVRPSE 367

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1728929573 482 WRYTAAAVLGSQIFIMGGDTEFTAAS----------AYRFDCEADQWTRI 521
Cdd:PLN02193  368 RSVFASAAVGKHIVIFGGEIAMDPLAhvgpgqltdgTFALDTETLQWERL 417
PLN02153 PLN02153
epithiospecifier protein
 327-546 3.34e-08

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 55.76  E-value: 3.34e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 327 PSPRKEFSACAIGCKVYITGGRGSEN-GVSKDVWVYDTVHEEWSKAAPM----LIARFGHGSAELENCLYVVGGHTAvag 401
Cdd:PLN02153   20 PGPRCSHGIAVVGDKLYSFGGELKPNeHIDKDLYVFDFNTHTWSIAPANgdvpRISCLGVRMVAVGTKLYIFGGRDE--- 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 402 vfpaspSVSLKQVEKYDPICNKWTMVAPL-RDGVSNA----AVVSARLKLFVFGGTSIHRDMVS-----KVQCYDPAENR 471
Cdd:PLN02153   97 ------KREFSDFYSYDTVKNEWTFLTKLdEEGGPEArtfhSMASDENHVYVFGGVSKGGLMKTperfrTIEAYNIADGK 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 472 WmikAECPQPW-----RYTAA-AVLGSQIFIM---------GGDTEFTAASAYRFDCEADQWTRIGDMTAKRMSCHALAS 536
Cdd:PLN02153  171 W---VQLPDPGenfekRGGAGfAVVQGKIWVVygfatsilpGGKSDYESNAVQFFDPASGKWTEVETTGAKPSARSVFAH 247

                         250
                  ....*....|
gi 1728929573 537 GnklyVVGGY 546
Cdd:PLN02153  248 A----VVGKY 253
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 45-88 6.23e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 51.62  E-value: 6.23e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1728929573  45 FTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLREslDDEVN 88
Cdd:cd18309    20 FCDITLLLDGHPIPAHKAILAARCSYFEAMFRSFMPE--DNTVN 61
Kelch smart00612
Kelch domain;
341-388 6.52e-08

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 49.09  E-value: 6.52e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1728929573  341 KVYITGGRGSENgVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELEN 388
Cdd:smart00612   1 KIYVVGGFDGGQ-RLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-135 8.90e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 50.71  E-value: 8.90e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLddevNFHDSLHPEVLELLLDFAYS 107
Cdd:cd18218     1 HSDRLLHLAARLRPAGALCDTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQW----CLGEGISPSTFKQLLDFVYG 76

                          90       100
                  ....*....|....*....|....*...
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDA 135
Cdd:cd18218    77 ESVEVQPGELRPLLEAARALEVESLEEA 104
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
517-565 1.11e-07

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 53.62  E-value: 1.11e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1728929573 517 QWTRIGDMTAKRMSCHALASGNKLYVVGGYFGTQRCKTLDCYDPTSDTW 565
Cdd:COG3055     2 TWSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTW 50
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 377-431 1.15e-07

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 48.38  E-value: 1.15e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1728929573 377 ARFGHGSAELENCLYVVGGHTAvagvfpaspSVSLKQVEKYDPICNKWTMVAPLR 431
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDG---------NQSLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-135 1.39e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 50.18  E-value: 1.39e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLR-KHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSnglrESLDDEVNFHDSLHPEVLELLLDFAY 106
Cdd:cd18226     4 YNKNLLKYLNDDRqKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLS----KNPNTDAVTLDHVSYSVFQHLLEFLY 79

                          90       100
                  ....*....|....*....|....*....
gi 1728929573 107 SSRIIINEENAESLLEAGdmlQFHDVRDA 135
Cdd:cd18226    80 TSEFFVYENEIPLVLEAA---KFLDIIDA 105
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-140 1.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 49.84  E-value: 1.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  32 VLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYF--EAMFSNGLRESLDDEVNfhdslhPEVLELLLDFAYSSR 109
Cdd:cd18210     8 LLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFhdQVLLKNMSSISLPGVMD------PGAFESVLASAYTGK 81

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1728929573 110 IIINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18210    82 LTMLADEIVNYLTVGSVLQMWHIVDKCTELL 112
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-132 2.06e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 49.79  E-value: 2.06e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  45 FTDVTLWAGNRSFPCHRAVLAASSRYFeamfsnglRESLDDEVNFHDSLHpeVLEL----------LLDFAYSSRIIINE 114
Cdd:cd18293    15 FCDVLLQAEGESVPAHCCVLSACSPYL--------TERLSSEPPPAGQKV--VLELqglkahtllkLVDFLYTSELEVSS 84

                          90
                  ....*....|....*...
gi 1728929573 115 ENAESLLEAGDMLQFHDV 132
Cdd:cd18293    85 EEAQDVLAAARRLQISEL 102
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-132 2.17e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 49.83  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEaMFsngLRESLD--DEVNFHDSL-HPEVLELLLDF 104
Cdd:cd18323     6 HSRHLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH-MF---YKEQLDkrDLVCINNEIvTAPAFSLLLEF 81

                          90       100
                  ....*....|....*....|....*...
gi 1728929573 105 AYSSRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18323    82 MYEGRLSFNDTPVEDVLAAASYLHMNDI 109
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 147-231 2.17e-07

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 48.80  E-value: 2.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 147 SNCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDERK 226
Cdd:cd18451     4 SNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAEERE 83


                  ....*
gi 1728929573 227 AYLPE 231
Cdd:cd18451    84 RYFEE 88
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-132 2.74e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 49.81  E-value: 2.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHPEVLELLLDFAYS 107
Cdd:cd18956     6 HGGRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPAGGRDTVRLNGDIVTAPAFGRLLDFMYE 85

                          90       100
                  ....*....|....*....|....*
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18956    86 GRLDLRSLPVEDVLAAASYLHMYDI 110
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 20-132 3.04e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 49.47  E-value: 3.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  20 ILLFHKAShPDCVLSHLNTLRKHCMFTDVTL---WAGNRS-FPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDSLHP 95
Cdd:cd18211     1 VLLESKSA-PSNLLNEMHKLRLLGHLCDVTVqveHQGSKEeFSAHKAVLAASSKYFKEVFLNEKISDGKNTNVMLNEIYT 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1728929573  96 EVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18211    80 ADFASFLEFVYTAKVEVEEDRVQRMLEIAEKLKCLDL 116
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-140 3.54e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 48.88  E-value: 3.54e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSnglRESLDDEVNFhdsLHPEVLELLLDFAYS 107
Cdd:cd18205     1 HPTGLLHKANQMRLAGTLCDVVIMVDSQEFHAHRTVLACTSKMFEILFH---RNSQHYTLDF---LSPKTFQQILEYAYT 74

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1728929573 108 SRIIINEENAESLLEAGDMLQFHDVRDAAAEFL 140
Cdd:cd18205    75 ATLQAKVEDLDDLLYAAEILEIEYLEEQCLKIL 107
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 41-107 3.79e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 48.90  E-value: 3.79e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1728929573  41 KHCMFTDVTLWA-GNRSFPCHRAVLAASSRYFEAMFSNGLRE-SLDDEVNFhdSLHPEVLELLLDFAYS 107
Cdd:cd18302     1 KHSDLYDVTIVSeDGKEFPCHKCVLVARLEYFHSMLSSSWIEaSSCSALTM--PIPSDILEIILDYLYT 67
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-132 6.65e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 48.49  E-value: 6.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFsnglRESLDDEVNFH---DSLHPEVLELLLDF 104
Cdd:cd18325     6 HSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFY----RDQLDKRDIVHlnsDIVTAPAFSLLLEF 81

                          90       100
                  ....*....|....*....|....*...
gi 1728929573 105 AYSSRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18325    82 MYEGKLEFSSLPVEDVLAAASYLHMYDI 109
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 44-128 7.25e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 48.04  E-value: 7.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  44 MFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFHDsLHPEVLELLLDFAYS---SRIIINEENAESL 120
Cdd:cd18297    11 EMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSSGSTEAQTPVIEIPD-IRYDIFQLMMQYLYTggvESLDVAQDDALEL 89


                  ....*...
gi 1728929573 121 LEAGDMLQ 128
Cdd:cd18297    90 LRAASFFQ 97
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 33-128 8.26e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 47.97  E-value: 8.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  33 LSHLNTLRKHCMFTDVTL-WAGNRSFPCHRAVLAASSRYFEAMfsNGLRESLDDEVNFHDSLHPEVLELLLDFAYSSRII 111
Cdd:cd18311     2 LQRLQNLFNKTEYCDLTLqFRDNEQLKVHRLVLSACTDYFNVL--EQTCEIVDDTLIMPNELQADAVVPVINFMYTGQLE 79

                          90
                  ....*....|....*..
gi 1728929573 112 INEENAESLLEAGDMLQ 128
Cdd:cd18311    80 FEEKSYGKLLRTAKELN 96
Kelch_4 pfam13418
Galactose oxidase, central domain;
329-374 8.34e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 46.07  E-value: 8.34e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1728929573 329 PRKEFSACAIGC-KVYITGGRGSENGVSKDVWVYDTVHEEWSKAAPM 374
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSL 47
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-113 9.79e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 47.92  E-value: 9.79e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMF----SNGLRESLDDEVNF-HDSLHPevlelLL 102
Cdd:cd18202     2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFiekgAVSSHEAVVDLSGFcKSSFLP-----LL 76

                          90
                  ....*....|.
gi 1728929573 103 DFAYSSRIIIN 113
Cdd:cd18202    77 EFAYTSELTFD 87
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 173-239 1.27e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 47.03  E-value: 1.27e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1728929573 173 LVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDlDERKAYLPELLRNVRLA 239
Cdd:cd18449    30 LKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRWLRHE-DDRMQFAAKLMENIRFP 95
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-131 1.85e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 46.95  E-value: 1.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNglRESLDDEVNFHDSLHPEVLELLLDFAYS 107
Cdd:cd18204     1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKK--LEVDSSSVIEIDFLRSDIFEEVLNYMYT 78

                          90       100
                  ....*....|....*....|....*.
gi 1728929573 108 SRIIINEENAESLLEAGDML--QFHD 131
Cdd:cd18204    79 AKISVKKEDVNLMMSSGQILgiRFLD 104
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-143 2.04e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 46.78  E-value: 2.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  32 VLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGlreslDDEVNFHDSLHPEVLELLLDFAYSSRII 111
Cdd:cd18229     5 LLETLNAQRLGGHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLLLG-----HSEIEVPPVVPAQTVRQLVEFMYSGSLV 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1728929573 112 INEENAESLLEAGDMLQFHDVRDAAAEFLEKN 143
Cdd:cd18229    80 VAQSEALQILTAASILQIKTVIDECTQIISQS 111
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-132 3.74e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 46.95  E-value: 3.74e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESldDEVNFH-DSLHPEVLELLLDFAY 106
Cdd:cd18324     6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR--DIVHLNsDIVTAPAFALLLEFMY 83

                          90       100
                  ....*....|....*....|....*.
gi 1728929573 107 SSRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18324    84 EGKLQFKDLPIEDVLAAASYLHMYDI 109
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-148 4.40e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 46.59  E-value: 4.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  53 GNRSFPCHRAVLAASSRYFEAMFSNGLrESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18346    40 GAQRIPAHRFVLAAGSAVFDAMFNGGM-ATTSAEIELPD-VEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPAL 117

                          90
                  ....*....|....*.
gi 1728929573 133 RDAAAEFLEKNLYPSN 148
Cdd:cd18346   118 EAHCVEFLTKHLRADN 133
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 44-121 5.19e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 45.70  E-value: 5.19e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1728929573  44 MFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESldDEVNF-HDSLHPEVLELLLDFAYSSRIIINEENAESLL 121
Cdd:cd18295    18 SYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDK--REINLkHPLVNPDAFRALLQYLYTGRLEIHVDDVEDCK 94
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 147-237 5.38e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 45.19  E-value: 5.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 147 SNCLGMMLLSDAHQCRRLYELSWRMCLVNFET-VHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDER 225
Cdd:cd18482     4 SNCAGILKFADAFDNRELKSKALAFIARNFQQlLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEANLKER 83

                          90
                  ....*....|..
gi 1728929573 226 KAYLPELLRNVR 237
Cdd:cd18482    84 AASAAEVLKCVR 95
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-148 6.63e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 45.83  E-value: 6.63e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  53 GNRSFPCHRAVLAASSRYFEAMFSNGLrESLDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18347    34 GSQRIPAHRFVLAVGSAVFDAMFNGGM-ATTSTEIELPD-VEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPAL 111

                          90
                  ....*....|....*.
gi 1728929573 133 RDAAAEFLEKNLYPSN 148
Cdd:cd18347   112 EAHCVEFLKKNLRADN 127
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-142 8.76e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 44.84  E-value: 8.76e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  28 HPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEamfsnglresldDEVNFHDS--------LHPEVLE 99
Cdd:cd18200     1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFH------------DKLLLNDTnclvlpsvIEAAAFE 68

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1728929573 100 LLLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Cdd:cd18200    69 NLLQLIYSGRLTLCMDALPSHLLVASGLQMWQVVDRCSELLKE 111
Kelch_6 pfam13964
Kelch motif;
329-378 8.96e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 43.09  E-value: 8.96e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1728929573 329 PRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIAR 378
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-141 9.15e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 45.25  E-value: 9.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  21 LLFHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMF----SNGLRESLddevnFHDSlhPE 96
Cdd:cd18203     1 LRFQLPGHEAATLRNMNQLRSEERFCDVTIVADSLKFRGHKVVLAACSPFLRDQFllnpSSELQVSL-----MHSS--RV 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1728929573  97 VLELLLD-----FAYSSRIIINEENAESLLEAGDMLQfhDVRDAAAEFLE 141
Cdd:cd18203    74 VADLLLScytgaLEFSVRDIVNYLTAASYLQMEHVVE--KCRGALSQFIE 121
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 47-150 1.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 44.40  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  47 DVTLWAGNRSFPCHRAVLAASSRYFEAMFSnglRESLDDEvnfhdSLHPEVLELLLDFAYSSRIIINEENAESLLEAGDM 126
Cdd:cd18275     6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLS---RDILKVK-----GLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARF 77

                          90       100
                  ....*....|....*....|....
gi 1728929573 127 LQFHDVRDAAAEFLEKNLYPSNCL 150
Cdd:cd18275    78 LQMPCAAQCAVDAVRAQLCLGNCY 101
BACK_BTBD9 cd14822
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); ...
 179-242 1.09e-05

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation.


Pssm-ID: 350518 [Multi-domain]  Cd Length: 101  Bit Score: 44.53  E-value: 1.09e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1728929573 179 VHKSEDFNNLSKDTLLDLISSD-----ELEIedeekvFKAVIQWVKYDlDERKAYLPELLRNVRLALLP 242
Cdd:cd14822    36 VLSSEGFLTLSKSALKELLSRDsfcapEVDI------FNAVRRWCEHN-PDSKEDAKEILEAVRLPLMS 97
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 481-525 1.12e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.60  E-value: 1.12e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1728929573 481 PWRYTAAAVLGSQIFIMGGDTEFTA-ASAYRFDCEADQWTRIGDMT 525
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSlNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-109 1.29e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 44.89  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  26 ASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNfhdSLHPEVLELLLDFA 105
Cdd:cd18213     2 SSHSLVLLQQLNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSECIKIQPT---DIQPDIFSYLLHIM 78


                  ....
gi 1728929573 106 YSSR 109
Cdd:cd18213    79 YTGK 82
Kelch_3 pfam13415
Galactose oxidase, central domain;
339-384 1.88e-05

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 42.28  E-value: 1.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1728929573 339 GCKVYITGGRGSENG-VSKDVWVYDTVHEEWSKAAPMLIARFGHGSA 384
Cdd:pfam13415   1 GDKLYIFGGLGFDGQtRLNDLYVYDLDTNTWTQIGDLPPPRSGHSAT 47
PRK14131 PRK14131
N-acetylneuraminate epimerase;
325-501 2.90e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.55  E-value: 2.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 325 DLPSPRKEFSACAIGCKVYItgGRGSengVSKDVWVYDT--VHEEWSKaapmlIARFGHG------SAELENCLYVVGGh 396
Cdd:PRK14131   24 DLPVPFKNGTGAIDNNTVYV--GLGS---AGTSWYKLDLnaPSKGWTK-----IAAFPGGpreqavAAFIDGKLYVFGG- 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 397 tavAGVFPASPSVSL-KQVEKYDPICNKWTMVA--PLRDGVSNAAVVSARLKLFVFGGTSIH------RDMVS------- 460
Cdd:PRK14131   93 ---IGKTNSEGSPQVfDDVYKYDPKTNSWQKLDtrSPVGLAGHVAVSLHNGKAYITGGVNKNifdgyfEDLAAagkdktp 169

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1728929573 461 --------------------KVQCYDPAENRWmiKAECPQPWRYTAaavlGSQIFIMGGDT 501
Cdd:PRK14131  170 kdkindayfdkkpedyffnkEVLSYDPSTNQW--KNAGESPFLGTA----GSAVVIKGNKL 224
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 46-144 3.34e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 43.15  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  46 TDVTLWAGN----RSFPCHRAVLAASSRYFEAMFSNGLRESlDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENA-ESL 120
Cdd:cd18282     8 ADVHFIVGPpggtQRIPAHKYVLATGSSVFYAMFYGGLAEN-KNEIEIPD-VEPAAFLNLLRYLYCDEIDLEPDTVlATL 85

                          90       100
                  ....*....|....*....|....
gi 1728929573 121 LEAGDMLQFHDVRdAAAEFLEKNL 144
Cdd:cd18282    86 YAAKKYLVPHLAR-ACVQFLETSL 108
BTB_POZ_KBTBD13 cd18320
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 45-87 6.52e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 13 (KBTBD13); KBTBD13 is a muscle specific protein. Its autosomal dominant mutations may cause Nemaline Myopathy (NEM). KBTBD13 may act as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that functions as a muscle specific ubiquitin ligase, and thereby implicating the ubiquitin proteasome pathway in the pathogenesis of KBTBD13-associated NEM. KBTBD13 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349629 [Multi-domain]  Cd Length: 83  Bit Score: 41.64  E-value: 6.52e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1728929573  45 FTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEV 87
Cdd:cd18320     1 MQKVKVWVEEQLFTVDKALLVENSEYFRALFRSGMRECTQDEI 43
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 327-363 6.82e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 40.24  E-value: 6.82e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1728929573 327 PSPRKEFSACAIGCKVYITGGR-GSENGVSKDVWVYDT 363
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYtGGEGQPSDDVYVLSL 38
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-142 7.25e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 42.36  E-value: 7.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  30 DCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLresldDEVNFHDSLHPEVLELLLDFAYSSR 109
Cdd:cd18208    10 NSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGY-----SDIEIPSVVSVQSVQKLIDFMYSGV 84

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1728929573 110 IIINEENAESLLEAGDMLQFHDVRDAAAEFLEK 142
Cdd:cd18208    85 LRVSQSEALQILTAASILQIKTVIDECTRIVSQ 117
BACK_KLHL14 cd18453
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also ...
 183-254 7.78e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 14 (KLHL14); KLHL14, also termed protein interactor of Torsin-1A, or Printor, or protein interactor of torsinA, is a novel ATP-free form of torsinA-interacting protein implicated in dystonia pathogenesis.


Pssm-ID: 350528  Cd Length: 102  Bit Score: 41.93  E-value: 7.78e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1728929573 183 EDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDLDERKAYLPELLRNVRLALLPSECLKEALACED 254
Cdd:cd18453    31 EDVLLLNFEEMRAMLDSLPPPVESELALFQMSVLWLEHDRETRMQYAPDLMKRLRFALIPAPELVERVQSVD 102
BACK_KLHL36 cd18475
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act ...
 148-242 8.58e-05

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.


Pssm-ID: 350550  Cd Length: 100  Bit Score: 41.75  E-value: 8.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 148 NCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDF-NNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDlDERK 226
Cdd:cd18475     5 NYLYLQELASIYSLERLDSFIDSFILQNFGTLSFTPDFlQNVSMQKLCQYLSSNQVQHECEHDLLQAALQWLTQS-PERE 83

                          90
                  ....*....|....*.
gi 1728929573 227 AYLPELLRNVRLALLP 242
Cdd:cd18475    84 NEAYQVLSNIHFPLIP 99
BACK_KLHL31_KBTBD1 cd18470
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also ...
 148-238 1.02e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 31 (KLHL31); KLHL31, also termed BTB and kelch domain-containing protein 6, or Kelch repeat and BTB domain-containing protein 1, or Kelch-like protein KLHL, is a transcriptional repressor in MAPK/JNK signaling pathway that regulates cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE).


Pssm-ID: 350545  Cd Length: 98  Bit Score: 41.40  E-value: 1.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 148 NCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDlDERKA 227
Cdd:cd18470     5 NCMYVVNIAETYGLKNTKEAAQKFIRDNFIEFSETDQFLKLTFEQINEFLIDDDLQLPSEITAFQIAMKWLDFD-QKRVK 83

                          90
                  ....*....|.
gi 1728929573 228 YLPELLRNVRL 238
Cdd:cd18470    84 YAADLLSNIRF 94
PLN02193 PLN02193
nitrile-specifier protein
 323-570 1.04e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 44.95  E-value: 1.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 323 KADLPSPRKEFSACAIGCKVYITGGRGSENG-VSKDVWVYDTVHEEWSKA-----APMLiARFGHGSAELENCLYVVGGH 396
Cdd:PLN02193  159 KGEGPGLRCSHGIAQVGNKIYSFGGEFTPNQpIDKHLYVFDLETRTWSISpatgdVPHL-SCLGVRMVSIGSTLYVFGGR 237

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 397 TAvagvfpaspSVSLKQVEKYDPICNKWTMVAPLRDGV---SNAAVVSARLKLFVFGGTSIhRDMVSKVQCYDPAENRWM 473
Cdd:PLN02193  238 DA---------SRQYNGFYSFDTTTNEWKLLTPVEEGPtprSFHSMAADEENVYVFGGVSA-TARLKTLDSYNIVDKKWF 307

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 474 ikaECPQPwrytaaavlGSQIFIMGGDteftaasayrfDCEADQwtrigdmtakrmschalasgNKLYVVGGYFGtqrCK 553
Cdd:PLN02193  308 ---HCSTP---------GDSFSIRGGA-----------GLEVVQ--------------------GKVWVVYGFNG---CE 341

                         250
                  ....*....|....*....
gi 1728929573 554 TLD--CYDPTSDTWNCITT 570
Cdd:PLN02193  342 VDDvhYYDPVQDKWTQVET 360
PLN02193 PLN02193
nitrile-specifier protein
 342-569 1.17e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 44.95  E-value: 1.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 342 VYITGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFG-----HGSAelenclyVVGGH---TAVAGVFPASPSVSLKQ 413
Cdd:PLN02193   75 VYVEGYREKVNDMTSEMITFLSFKTYKGKTSHPIEKRPGvkfvlQGGK-------IVGFHgrsTDVLHSLGAYISLPSTP 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 414 vekydPICNKWTMVAPLRDGVS---NAAVVSARLKLFVFGGTSIHRDMVSK-VQCYDPAENRWMIKAECPQPWRYTAAAV 489
Cdd:PLN02193  148 -----KLLGKWIKVEQKGEGPGlrcSHGIAQVGNKIYSFGGEFTPNQPIDKhLYVFDLETRTWSISPATGDVPHLSCLGV 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 490 ----LGSQIFIMGG-DTEFTAASAYRFDCEADQW---TRIGDMTAKRmSCHALASG-NKLYVVGGYFGTQRCKTLDCYDP 560
Cdd:PLN02193  223 rmvsIGSTLYVFGGrDASRQYNGFYSFDTTTNEWkllTPVEEGPTPR-SFHSMAADeENVYVFGGVSATARLKTLDSYNI 301

                         250
                  ....*....|
gi 1728929573 561 TSDTW-NCIT 569
Cdd:PLN02193  302 VDKKWfHCST 311
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 148-220 1.35e-04

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 40.79  E-value: 1.35e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1728929573 148 NCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKY 220
Cdd:cd18503     5 NCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNWTEH 77
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-146 1.38e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 41.73  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  21 LLFHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSngLRESldDEVNFHDSLHPEVLEL 100
Cdd:cd18214     1 LHFRFENYGDSMLQKMNKLREQNKFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFL--LNDS--REVQISILQNSEVGRQ 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1728929573 101 LLDFAYSSRIIINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLYP 146
Cdd:cd18214    77 LLLSCYTGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKP 122
BACK_KBTBD4 cd18481
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 148-234 1.84e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also termed BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates.


Pssm-ID: 350556  Cd Length: 88  Bit Score: 40.64  E-value: 1.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 148 NCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDeleIEDEEKVFKAVIQWVKYDlDERKA 227
Cdd:cd18481     5 NCLQVMWLADQHSDQELYTAAKHCAKTHLSQLHQTEEFLNLPLRLLTDIIKDG---VPCSQNPTAAIEAWINHN-KEERE 80


                  ....*..
gi 1728929573 228 YLPELLR 234
Cdd:cd18481    81 GFSETLT 87
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 148-241 2.65e-04

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 40.51  E-value: 2.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 148 NCLGMMLLSDAHQCRRLYELSWRMCLVNFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWvKYDLDERKA 227
Cdd:cd18461     5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGALLY-HYTPEQVEK 83

                          90       100
                  ....*....|....*....|
gi 1728929573 228 ------YLPELLRNVRLALL 241
Cdd:cd18461    84 dqvslqEPPKLLEAVRFPLM 103
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-128 3.86e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 40.24  E-value: 3.86e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  21 LLFHKASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSngLRESLDDEVNFHDSlhPEVLEL 100
Cdd:cd18197     1 LHFKFEQQGDAVLQKMNLLRQQNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFL--LNQSKQVRITILQS--AEVGRK 76

                          90       100
                  ....*....|....*....|....*...
gi 1728929573 101 LLDFAYSSRIIINEENAESLLEAGDMLQ 128
Cdd:cd18197    77 LLLSCYTGALEVKKKELLKYLTAASYLQ 104
BTB1_POZ_BTBD8 cd18285
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 44-120 4.04e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349594 [Multi-domain]  Cd Length: 104  Bit Score: 40.03  E-value: 4.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  44 MFTDVTLWAGNRSFPCHRAVLAASSRYFeAMFSNGLRESLDDE--VNFHDslhPEVLEL--LLDFAYSSRIIINEENAES 119
Cdd:cd18285    14 LHTDVTFYVGSTLFKAHKAILLARVPEF-FSHIIGKLSSLEDQepINIEN---LEASEFktFLRQVYTSDKNIKMLEEEI 89


                  .
gi 1728929573 120 L 120
Cdd:cd18285    90 L 90
PLN02193 PLN02193
nitrile-specifier protein
 294-451 4.16e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 43.02  E-value: 4.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 294 GHTLLILGGQTF--MCDKIYQVD---HKAKEIIPKADLPSPRKEFSACAIGCKVYITGGRGSENGVsKDVWVYDTVHEEW 368
Cdd:PLN02193  228 GSTLYVFGGRDAsrQYNGFYSFDtttNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARL-KTLDSYNIVDKKW 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 369 ---SKAAPMLIARFGHGSAELENCLYVVGGHTAvagvfpaspsVSLKQVEKYDPICNKWTMVA-----PLRDGVSNAAVV 440
Cdd:PLN02193  307 fhcSTPGDSFSIRGGAGLEVVQGKVWVVYGFNG----------CEVDDVHYYDPVQDKWTQVEtfgvrPSERSVFASAAV 376

                         170
                  ....*....|.
gi 1728929573 441 SARlkLFVFGG 451
Cdd:PLN02193  377 GKH--IVIFGG 385
Kelch_6 pfam13964
Kelch motif;
481-528 4.35e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 38.47  E-value: 4.35e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1728929573 481 PWRYTAAAVLGSQIFIMGGDTEFTAASA--YRFDCEADQWTRIGDMTAKR 528
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYTNASPALNklEVYNPLTKSWEELPPLPTPR 50
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 53-144 4.65e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 39.97  E-value: 4.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  53 GNRSFPCHRAVLAASSRYFEAMFSNGLRESlDDEVNFHDsLHPEVLELLLDFAYSSRIIINEENAESLLEAGDMLQFHDV 132
Cdd:cd18349    20 ASQRVPAHKYVLAVGSSVFYAMFYGDLAEV-KSEIHIPD-VEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPAL 97

                          90
                  ....*....|..
gi 1728929573 133 RDAAAEFLEKNL 144
Cdd:cd18349    98 AKACVNFLETSL 109
Kelch smart00612
Kelch domain;
493-539 6.52e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.54  E-value: 6.52e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1728929573  493 QIFIMGG-DTEFTAASAYRFDCEADQWTRIGDMTAKRMScHALASGNK 539
Cdd:smart00612   1 KIYVVGGfDGGQRLKSVEVYDPETNKWTPLPSMPTPRSG-HGVAVING 47
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-110 1.01e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 39.20  E-value: 1.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573  26 ASHPDCVLSHLNTLRKHCMFTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNfhdSLHPEVLELLLDFA 105
Cdd:cd18193     2 ANHGLILLQQLNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSECVRLKPT---DIQPDIFSYLLHLM 78


                  ....*
gi 1728929573 106 YSSRI 110
Cdd:cd18193    79 YTGKM 83
PRK14131 PRK14131
N-acetylneuraminate epimerase;
477-582 1.49e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 41.15  E-value: 1.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 477 ECPQPWRYTAAAVLGSQIFIMGGDTEftaASAYRFDCEA--DQWTRIGDM-TAKRMSCHALASGNKLYVVGGyFG----- 548
Cdd:PRK14131   24 DLPVPFKNGTGAIDNNTVYVGLGSAG---TSWYKLDLNApsKGWTKIAAFpGGPREQAVAAFIDGKLYVFGG-IGktnse 99

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1728929573 549 --TQRCKTLDCYDPTSDTWNCI-TTVPYSLIPTAFVS 582
Cdd:PRK14131  100 gsPQVFDDVYKYDPKTNSWQKLdTRSPVGLAGHVAVS 136
PLN02193 PLN02193
nitrile-specifier protein
 475-582 2.56e-03

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 40.71  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 475 KAECPQPWRYTAAAVLGSQIFIMGGdtEFTAASA-----YRFDCEADQWT---RIGDMtaKRMSC---HALASGNKLYVV 543
Cdd:PLN02193  159 KGEGPGLRCSHGIAQVGNKIYSFGG--EFTPNQPidkhlYVFDLETRTWSispATGDV--PHLSClgvRMVSIGSTLYVF 234

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1728929573 544 GGYFGTQRCKTLDCYDPTSDTWNCITTVPYSLIPTAFVS 582
Cdd:PLN02193  235 GGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHS 273
BACK_KLHL32_BKLHD5 cd18471
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also ...
 173-241 2.78e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also termed BTB and kelch domain-containing protein 5 (BKLHD5), belongs to the KLHL family. Its function remains unclear. KLHL32 SNPs may be associated with body mass index in individuals of African ancestry.


Pssm-ID: 350546 [Multi-domain]  Cd Length: 98  Bit Score: 37.58  E-value: 2.78e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1728929573 173 LVNFETVHKSEDFNNLSKDTLL-------DLISSDELEIEDEEKVFKAVIQWVKYDLdeRKAYLPELLRNVRLALL 241
Cdd:cd18471    25 VVDFLVKHLSELLKSHPEEVLAlpyrllrEVLKSDRLTSLSEEQIWQLAVRWLEHNC--RYQYMDELLQYVRFGLM 98
Kelch_3 pfam13415
Galactose oxidase, central domain;
491-536 3.05e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 35.73  E-value: 3.05e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1728929573 491 GSQIFIMGGDTEFTAA---SAYRFDCEADQWTRIGDMTAKRMsCHALAS 536
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTrlnDLYVYDLDTNTWTQIGDLPPPRS-GHSATY 48
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 41-115 3.33e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 38.02  E-value: 3.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1728929573  41 KHCM----FTDVTLWAGNRSFPCHRAVLAASSRYFEAMFSNGLRESLDDEVNFhDSLHPEVLELLLDFAYSSRIIINEE 115
Cdd:cd18358    12 KECLskgtFSDVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVL-PNISKVSMQAVLDYLYTKQLSPTAD 89
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 528-569 3.37e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.77  E-value: 3.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1728929573 528 RMSCHALAS-GNKLYVVGGYFGTQRCKTLD--CYDPTSDTWNCIT 569
Cdd:pfam07646   1 PRYPHASSVpGGKLYVVGGSDGLGDLSSSDvlVYDPETNVWTEVP 45
PRK14131 PRK14131
N-acetylneuraminate epimerase;
469-546 4.33e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 39.61  E-value: 4.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1728929573 469 ENRWMIKAECPQPWRYTA-AAVLGSQIFIMGG------DTEFTAAS-AYRFDCEADQWTRIGDMTAKRMSCHALAS--GN 538
Cdd:PRK14131   61 SKGWTKIAAFPGGPREQAvAAFIDGKLYVFGGigktnsEGSPQVFDdVYKYDPKTNSWQKLDTRSPVGLAGHVAVSlhNG 140


                  ....*...
gi 1728929573 539 KLYVVGGY 546
Cdd:PRK14131  141 KAYITGGV 148
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 435-479 4.45e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 4.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1728929573 435 SNAAVVSARLKLFVFGGtSIHRDMVSKVQCYDPAENRWMIKAECP 479
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGG-FDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_4 pfam13418
Galactose oxidase, central domain;
528-573 5.76e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 35.28  E-value: 5.76e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1728929573 528 RMsCHALAS--GNKLYVVGGYFG-TQRCKTLDCYDPTSDTWNCITTVPY 573
Cdd:pfam13418   2 RA-YHTSTSipDDTIYLFGGEGEdGTLLSDLWVFDLSTNEWTRLGSLPS 49
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 166-217 5.91e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 35.75  E-value: 5.91e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1728929573 166 ELSWRmCLV----NFETVHKSEDFNNLSKDTLLDLISSDELEIeDEEKVFKAVIQW 217
Cdd:cd18494    19 ELKER-CLAfieeHTEEVFKTKGFHELSDEALSVILRSDKLRI-DELDILKAVREW 72
BACK_KLHL26 cd18465
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a ...
 175-241 8.65e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is a kelch family protein encoded by gene klhl26, which is regulated by p53 via fuzzy tandem repeats.


Pssm-ID: 350540  Cd Length: 97  Bit Score: 36.04  E-value: 8.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1728929573 175 NFETVHKSEDFNNLSKDTLLDLISSDELEIEDEEKVFKAVIQWVKYDlDERKAYLPELLRNVRLALL 241
Cdd:cd18465    32 HFLQIAEEEDFLHLPLERLVFFLQSNKLKNCSEIDLFRAAIRWLQHD-PSRRASASHVLCHIRFPLM 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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