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Conserved domains on  [gi|1751555422|ref|XP_030817164|]
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adenylate kinase isoenzyme 1 isoform X2 [Camarhynchus parvulus]

Protein Classification

nucleoside monophosphate kinase( domain architecture ID 11492279)

nucleoside monophosphate kinase catalyzes the transfer of the terminal phosphoryl group from a nucleoside triphosphate, usually ATP, to a nucleoside monophosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 7-194 1.12e-132

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


:

Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 369.53  E-value: 1.12e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422   7 KQHKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVAKAD 86
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  87 VSKGFLIDGYPREVKQGEEFEKKIAPPTLLLYVDAGKDTMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYK 166
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1751555422 167 SRGIVRQLNAEGSVEEVFQQVCTHLDCL 194
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 7-194 1.12e-132

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 369.53  E-value: 1.12e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422   7 KQHKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVAKAD 86
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  87 VSKGFLIDGYPREVKQGEEFEKKIAPPTLLLYVDAGKDTMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYK 166
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1751555422 167 SRGIVRQLNAEGSVEEVFQQVCTHLDCL 194
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 11-183 1.35e-76

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 227.89  E-value: 1.35e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  11 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSKG 90
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  91 FLIDGYPREVKQGEEFEKKI---APPTLLLYVDAGKDTMVKRLLKRGET-------------------SGRVDDNEETIK 148
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1751555422 149 KRLETYYKATEPVIAFYKSRGIVRQLNAEGSVEEV 183
Cdd:cd01428   160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
14-168 3.85e-72

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 216.02  E-value: 3.85e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  14 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSKGFLI 93
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  94 DGYPREVKQGEEFE---KKIAPPTLLLYVDAGKDTMVKRLLKRGET---------------------------SGRVDDN 143
Cdd:pfam00406  80 DGFPRTVPQAEALEellERGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 1751555422 144 EETIKKRLETYYKATEPVIAFYKSR 168
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 10-191 1.23e-69

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 210.75  E-value: 1.23e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSK 89
Cdd:COG0563     2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERL-AQPDCAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  90 GFLIDGYPREVKQGEEFEKKIA----PPTLLLYVDAGKDTMVKRLLKR---------------------------GETSG 138
Cdd:COG0563    80 GFILDGFPRTVAQAEALDELLAelgiKLDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1751555422 139 RVDDNEETIKKRLETYYKATEPVIAFYKSRGIVRQLNAEGSVEEVFQQVCTHL 191
Cdd:COG0563   160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 10-192 7.82e-67

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 203.84  E-value: 7.82e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSK 89
Cdd:PRK00279    2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERL-AQPDCKN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  90 GFLIDGYPREVKQGEEFEKKIA----PPTLLLYVDAGKDTMVKRLLKR---------------------------GETSG 138
Cdd:PRK00279   80 GFLLDGFPRTIPQAEALDEMLKelgiKLDAVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1751555422 139 RVDDNEETIKKRLETYYKATEPVIAFYKSRGIVRQLNAEGSVEEVFQQVCTHLD 192
Cdd:PRK00279  160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALG 213
 
Name Accession Description Interval E-value
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 7-194 1.12e-132

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 369.53  E-value: 1.12e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422   7 KQHKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVAKAD 86
Cdd:TIGR01360   1 AKCKIIFIVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  87 VSKGFLIDGYPREVKQGEEFEKKIAPPTLLLYVDAGKDTMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYK 166
Cdd:TIGR01360  81 TSKGFLIDGYPREVKQGEEFERRIGPPTLVLYFDCSEDTMVKRLLKRAETSGRVDDNEKTIKKRLETYYKATEPVIAYYE 160

                         170       180
                  ....*....|....*....|....*...
gi 1751555422 167 SRGIVRQLNAEGSVEEVFQQVCTHLDCL 194
Cdd:TIGR01360 161 TKGKLRKINAEGTVDDVFLQVCTAIDKL 188
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 11-183 1.35e-76

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 227.89  E-value: 1.35e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  11 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSKG 90
Cdd:cd01428     1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERL-KKPDCKKG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  91 FLIDGYPREVKQGEEFEKKI---APPTLLLYVDAGKDTMVKRLLKRGET-------------------SGRVDDNEETIK 148
Cdd:cd01428    80 FILDGFPRTVDQAEALDELLdegIKPDKVIELDVPDEVLIERILGRRICpvsgrvyhlgkddvtgeplSQRSDDNEETIK 159

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1751555422 149 KRLETYYKATEPVIAFYKSRGIVRQLNAEGSVEEV 183
Cdd:cd01428   160 KRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
ADK pfam00406
Adenylate kinase;
14-168 3.85e-72

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 216.02  E-value: 3.85e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  14 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSKGFLI 93
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERL-EQNDCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  94 DGYPREVKQGEEFE---KKIAPPTLLLYVDAGKDTMVKRLLKRGET---------------------------SGRVDDN 143
Cdd:pfam00406  80 DGFPRTVPQAEALEellERGIKLDYVIEFDVPDEVLVERLTGRRIHpnsgrsyhlefnppkvpgkddvtgeplVQRSDDN 159

                         170       180
                  ....*....|....*....|....*
gi 1751555422 144 EETIKKRLETYYKATEPVIAFYKSR 168
Cdd:pfam00406 160 EETVKKRLETYHKQTKPLIDYYKKK 184
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 11-187 5.28e-70

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 210.69  E-value: 5.28e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  11 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVS-SGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVAKADvSK 89
Cdd:TIGR01359   1 VVFVLGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGS-SK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  90 GFLIDGYPREVKQGEEFEKKI---APPTLLLYVDAGKDTMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFYK 166
Cdd:TIGR01359  80 KFLIDGFPRNEENLEAWEKLMdnkVNFKFVLFFDCPEETMIKRLLKRGQTSGRVDDNIETLKKRFRTYNEETLPIIEHFE 159

                         170       180
                  ....*....|....*....|.
gi 1751555422 167 SRGIVRQLNAEGSVEEVFQQV 187
Cdd:TIGR01359 160 NKGKVKEINAEGSVEEVFEDV 180
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 10-191 1.23e-69

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 210.75  E-value: 1.23e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSK 89
Cdd:COG0563     2 RIILL-GPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERL-AQPDCAN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  90 GFLIDGYPREVKQGEEFEKKIA----PPTLLLYVDAGKDTMVKRLLKR---------------------------GETSG 138
Cdd:COG0563    80 GFILDGFPRTVAQAEALDELLAelgiKLDAVIELDVDDEELVERLSGRrvcpncgatyhvkfnppkvegvcdkcgGELVQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1751555422 139 RVDDNEETIKKRLETYYKATEPVIAFYKSRGIVRQLNAEGSVEEVFQQVCTHL 191
Cdd:COG0563   160 RADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 10-192 7.82e-67

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 203.84  E-value: 7.82e-67
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSK 89
Cdd:PRK00279    2 RLILL-GPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERL-AQPDCKN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  90 GFLIDGYPREVKQGEEFEKKIA----PPTLLLYVDAGKDTMVKRLLKR---------------------------GETSG 138
Cdd:PRK00279   80 GFLLDGFPRTIPQAEALDEMLKelgiKLDAVIEIDVPDEELVERLSGRricpacgrtyhvkfnppkvegkcdvcgEELIQ 159

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1751555422 139 RVDDNEETIKKRLETYYKATEPVIAFYKSRGIVRQLNAEGSVEEVFQQVCTHLD 192
Cdd:PRK00279  160 RADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALG 213
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 10-187 3.13e-59

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 184.36  E-value: 3.13e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVAKADVSK 89
Cdd:TIGR01351   1 RLVLL-GPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNEN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  90 GFLIDGYPREVKQGEEFEKKIA-PPTLLLYVDAGKDTMVKRLLKRG--ETSGRV-------------------------D 141
Cdd:TIGR01351  80 GFILDGFPRTLSQAEALDALLEePIDAVIELDVPDEELVERLSGRRicPSCGRVyhlkfnppkvpgcddctgellvqreD 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1751555422 142 DNEETIKKRLETYYKATEPVIAFYKSRGIVRQLNAEGSVEEVFQQV 187
Cdd:TIGR01351 160 DTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRI 205
PLN02200 PLN02200
adenylate kinase family protein
 11-187 4.70e-52

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 166.99  E-value: 4.70e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  11 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSKg 90
Cdd:PLN02200   45 ITFVLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEM-ESSDNNK- 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  91 FLIDGYPREVKQGEEFEKKI-APPTLLLYVDAGKDTMVKRLLKRGEtsGRVDDNEETIKKRLETYYKATEPVIAFYKSRG 169
Cdd:PLN02200  123 FLIDGFPRTEENRIAFERIIgAEPNVVLFFDCPEEEMVKRVLNRNQ--GRVDDNIDTIKKRLKVFNALNLPVIDYYSKKG 200

                         170
                  ....*....|....*...
gi 1751555422 170 IVRQLNAEGSVEEVFQQV 187
Cdd:PLN02200  201 KLYTINAVGTVDEIFEQV 218
PRK14531 PRK14531
adenylate kinase; Provisional
 8-192 5.27e-50

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 159.98  E-value: 5.27e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422   8 QHKIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvaKADV 87
Cdd:PRK14531    2 KQRLLFL-GPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQL--KALN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  88 SKGFLIDGYPREVKQGEEFE------KKIAPPTLLLYVDagKDTMVKRLLKRgetsGRVDDNEETIKKRLETYYKATEPV 161
Cdd:PRK14531   79 SGGWLLDGFPRTVAQAEALEplleelKQPIEAVVLLELD--DAVLIERLLAR----GRADDNEAVIRNRLEVYREKTAPL 152

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1751555422 162 IAFYKSRGIVRQLNAEGSVEEVFQQVCTHLD 192
Cdd:PRK14531  153 IDHYRQRGLLQSVEAQGSIEAITERIEKVLA 183
PRK14527 PRK14527
adenylate kinase; Provisional
 10-187 8.59e-49

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 157.26  E-value: 8.59e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVAKADVSK 89
Cdd:PRK14527    7 KVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAGMEPVRV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  90 GFliDGYPREVKQGEEFEKKI----APPTLLLYVDAGKDTMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFY 165
Cdd:PRK14527   87 IF--DGFPRTLAQAEALDRLLeelgARLLAVVLLEVPDEELIRRIVERARQEGRSDDNEETVRRRQQVYREQTQPLVDYY 164

                         170       180
                  ....*....|....*....|..
gi 1751555422 166 KSRGIVRQLNAEGSVEEVFQQV 187
Cdd:PRK14527  165 EARGHLKRVDGLGTPDEVYARI 186
PRK14528 PRK14528
adenylate kinase; Provisional
 10-183 1.75e-45

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 148.62  E-value: 1.75e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVaKADVSK 89
Cdd:PRK14528    3 NIIFM-GPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIR-EADCKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  90 GFLIDGYPREVKQGEEFEKKIAPPTL----LLYVDAGKDTMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAFY 165
Cdd:PRK14528   81 GFLLDGFPRTVEQADALDALLKNEGKsidkAINLEVPDGELLKRLLGRAEIEGRADDNEATIKNRLDNYNKKTLPLLDFY 160

                         170
                  ....*....|....*...
gi 1751555422 166 KSRGIVRQLNAEGSVEEV 183
Cdd:PRK14528  161 AAQKKLSQVNGVGSLEEV 178
PRK14532 PRK14532
adenylate kinase; Provisional
 11-183 2.69e-44

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 145.35  E-value: 2.69e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  11 IIFvvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSKG 90
Cdd:PRK14532    4 ILF--GPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERL-PEAEAAGG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  91 FLIDGYPREVKQGEEFEKKIAP------PTLLLYVDagKDTMVKRLLKRGETSGRVDDNEETIKKRLETYYKATEPVIAF 164
Cdd:PRK14532   81 AIFDGFPRTVAQAEALDKMLASrgqkidVVIRLKVD--DEALIERIVKRFEEQGRPDDNPEVFVTRLDAYNAQTAPLLPY 158

                         170
                  ....*....|....*....
gi 1751555422 165 YKSRGIVRQLNAEGSVEEV 183
Cdd:PRK14532  159 YAGQGKLTEVDGMGSIEAV 177
adk PRK02496
adenylate kinase; Provisional
 10-183 4.72e-43

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 142.20  E-value: 4.72e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSK 89
Cdd:PRK02496    3 RLIFL-GPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERL-QQPDAAN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  90 GFLIDGYPREVKQGEEFEK---KIAPP-TLLLYVDAGKDTMVKRLLKRgetsGRVDDNEETIKKRLETYYKATEPVIAFY 165
Cdd:PRK02496   81 GWILDGFPRKVTQAAFLDEllqEIGQSgERVVNLDVPDDVVVERLLAR----GRKDDTEEVIRRRLEVYREQTAPLIDYY 156

                         170
                  ....*....|....*...
gi 1751555422 166 KSRGIVRQLNAEGSVEEV 183
Cdd:PRK02496  157 RDRQKLLTIDGNQSVEAV 174
AAA_17 pfam13207
AAA domain;
15-148 6.94e-43

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 140.07  E-value: 6.94e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  15 VGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSerGKKLQAIMEKGELVPLDTVLDMLRDAMvAKADVSKGFLID 94
Cdd:pfam13207   1 TGVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERI-AEEAGEGGVIVD 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  95 GYPREVKQGEEFEK------KIAPPTLLLYVDAGKDTMVKRLLKRgETSGRVDDNEETIK 148
Cdd:pfam13207  78 GHPRIKTPAGYLPGlpvevlRELKPDAIILLEADPEEILERRLKD-RTRGRDDDSEEEIR 136
PLN02842 PLN02842
nucleotide kinase
 14-192 5.75e-38

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 136.53  E-value: 5.75e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  14 VVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVAKADVSKGFLI 93
Cdd:PLN02842    2 ISGAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  94 DGYPREVKQGEEFEKKIAPPTLLLYVDAGKDTMVKRLLKR-------------------GETSGRV----DDNEETIKKR 150
Cdd:PLN02842   82 DGYPRSFAQAQSLEKLKIRPDIFILLDVPDEILIDRCVGRrldpvtgkiyhiknfppesEEIKARLitrpDDTEEKVKAR 161

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1751555422 151 LETYYKATEPVIAFYKSrgIVRQLNAEGSVEEVFQQVCTHLD 192
Cdd:PLN02842  162 LQIYKKNAEAILSTYSD--IMVKIDGNRPKEVVFEEISSLLS 201
PRK14530 PRK14530
adenylate kinase; Provisional
 9-192 1.65e-36

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 126.44  E-value: 1.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422   9 HKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRA---------EVSSGSERgkklqAIMEKGELVPlDTVLDMLRD 79
Cdd:PRK14530    3 QPRILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRAnkqmdisdmDTEYDTPG-----EYMDAGELVP-DAVVNEIVE 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  80 AMVAKADvskGFLIDGYPREVKQGEEFEKkIAPPTLLLYVDAGKDTMVKRLLKR-------------------------- 133
Cdd:PRK14530   77 EALSDAD---GFVLDGYPRNLEQAEYLES-ITDLDVVLYLDVSEEELVDRLTGRrvcpdcganyhvefnqpeeegvcdec 152

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422 134 -GETSGRVDDNEETIKKRLETYYKATEPVIAFYKSRGIVRQLNAEGSVEEVFQQVCTHLD 192
Cdd:PRK14530  153 gGELIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADIQDAID 212
PLN02674 PLN02674
adenylate kinase
 7-187 1.35e-33

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 119.60  E-value: 1.35e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422   7 KQHKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvAKAD 86
Cdd:PLN02674   29 KPDKRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGIIDEAM-KKPS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  87 VSKGFLIDGYPREV-----------KQGEEFEK------------------------------KIAPPTLllyvdAGKDT 125
Cdd:PLN02674  108 CQKGFILDGFPRTVvqaqkldemlaKQGAKIDKvlnfaiddaileeritgrwihpssgrtyhtKFAPPKV-----PGVDD 182

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1751555422 126 MVKRLLKRgetsgRVDDNEETIKKRLETYYKATEPVIAFYKSRGIVRQLNAEGSVEEVFQQV 187
Cdd:PLN02674  183 VTGEPLIQ-----RKDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEV 239
PLN02459 PLN02459
probable adenylate kinase
 16-182 1.69e-29

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 109.55  E-value: 1.69e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  16 GGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVA-KADVSKGFLID 94
Cdd:PLN02459   36 GCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAgEEEGESGFILD 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  95 GYPREVKQGEEFEkKIAPPTLLLYVDAGKDTMVKRLLKR---GETSG--------------------------------- 138
Cdd:PLN02459  116 GFPRTVRQAEILE-GVTDIDLVVNLKLREEVLVEKCLGRricSECGKnfnvadidlkgedgrpgivmppllpppecaskl 194

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1751555422 139 --RVDDNEETIKKRLETYYKATEPVIAFYKSRGIVRQLNAEGSVEE 182
Cdd:PLN02459  195 itRADDTEEVVKARLRVYKEESQPVEDFYRKRGKLLEFELPGGIPE 240
PRK13808 PRK13808
adenylate kinase; Provisional
 12-187 3.25e-29

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 110.36  E-value: 3.25e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  12 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDaMVAKADVSKGF 91
Cdd:PRK13808    3 LILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISD-RIEQPDAANGF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  92 LIDGYPREVKQGEEF-----EKKIAPPTLL-LYVDAGK-----DTMVKRLLKRGETSgRVDDNEETIKKRLETYYKATEP 160
Cdd:PRK13808   82 ILDGFPRTVPQAEALdallkDKQLKLDAVVeLRVNEGAllarvETRVAEMRARGEEV-RADDTPEVLAKRLASYRAQTEP 160

                         170       180
                  ....*....|....*....|....*..
gi 1751555422 161 VIAFYKSRGIVRQLNAEGSVEEVFQQV 187
Cdd:PRK13808  161 LVHYYSEKRKLLTVDGMMTIDEVTREI 187
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 5-170 8.23e-26

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 99.10  E-value: 8.23e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422   5 KLKQHKIIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVAK 84
Cdd:PTZ00088    2 KLKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAKV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  85 AD-VSKGFLIDGYPREVKQGEEFeKKIAPPTLLLYVDAGKDTMVKRLLKR----------------------------GE 135
Cdd:PTZ00088   82 TDdCFKGFILDGFPRNLKQCKEL-GKITNIDLFVNIYLPRNILIKKLLGRricntcnrnfniahirsdpydmppilppAD 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1751555422 136 TSG---------RVDDNEETIKKRLETYYKATEPVIAFYKSRGI 170
Cdd:PTZ00088  161 CEGckgnpklqkRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
PRK14526 PRK14526
adenylate kinase; Provisional
 10-183 9.68e-25

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 95.69  E-value: 9.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVvGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVAKADvSK 89
Cdd:PRK14526    2 KLVFL-GPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKINTIKN-ND 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  90 GFLIDGYPREVKQGEEFEkKIAPPTLLLYVDAGKDTMVKRLLKR---------------------------GETSGRVDD 142
Cdd:PRK14526   80 NFILDGFPRNINQAKALD-KFLPNIKIINFLIDEELLIKRLSGRrickscnnifniytlptkekgicdvckGDLYQRKDD 158

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1751555422 143 NEETIKKRLETYYKATEPVIAFYKSRGIVRQLNAEGSVEEV 183
Cdd:PRK14526  159 KEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDASKDIDEV 199
PRK14529 PRK14529
adenylate kinase; Provisional
 12-183 7.49e-22

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 88.62  E-value: 7.49e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  12 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMvaKADVSKGF 91
Cdd:PRK14529    3 ILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETL--KQDGKNGW 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  92 LIDGYPREVKQGEEFEKKIAPPTLLL-YV-------DAGKD-TMVKRLLKR------------------------GETSG 138
Cdd:PRK14529   81 LLDGFPRNKVQAEKLWEALQKEGMKLdYVieillprEVAKNrIMGRRLCKNdnnhpnnifidaikpdgdvcrvcgGELST 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1751555422 139 RVDD-NEETIKKRLETYYKATEPVIA---FYK---SRGIVR--QLNAEGSVEEV 183
Cdd:PRK14529  161 RADDqDEEAINKRHDIYYDTETGTLAaayFFKdlaAKGSTKyiELDGEGSIDEI 214
TMPK cd01672
Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the ...
 10-192 3.85e-08

Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step in either de novo or salvage biosynthesis of thymidine triphosphate (TTP).


Pssm-ID: 238835  Cd Length: 200  Bit Score: 51.12  E-value: 3.85e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVVGGPGSGKGTQCEKIVQ---KYGYTHLSTGDLlraevsSGSERGKKLQAIMEKGELVPLDTVLDML-----RDAM 81
Cdd:cd01672     1 MFIVFEGIDGAGKTTLIELLAErleARGYEVVLTREP------GGTPIGEAIRELLLDPEDEKMDPRAELLlfaadRAQH 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  82 VA---KADVSKGFLI--D----------GYPR-----EVKQGEEFEKKIAPPTLLLYVDAGKDTMVKRLLKRGETSGRVD 141
Cdd:cd01672    75 VEeviKPALARGKIVlsDrfvdsslayqGAGRglgeaLIEALNDLATGGLKPDLTILLDIDPEVGLARIEARGRDDRDEQ 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1751555422 142 DNEETIKKRLETYYKatepVIAFYKSRGIVrqLNAEGSVEEVFQQVCTHLD 192
Cdd:cd01672   155 EGLEFHERVREGYLE----LAAQEPERIIV--IDASQPLEEVLAEILKAIL 199
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 12-154 2.99e-07

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 47.69  E-value: 2.99e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  12 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAImekGELVPlDTVLDMLRDAMVAKADVskgf 91
Cdd:pfam13671   2 ILLVGLPGSGKSTLARRLLEELGAVRLSSDDERKRLFGEGRPSISYYTDA---TDRTY-ERLHELARIALRAGRPV---- 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1751555422  92 LIDG---YPREVKQGEEFEKKIAPPTLLLYVDAGKDTMVKRLLKRGETSG-RVDDNEETIKKRLETY 154
Cdd:pfam13671  74 ILDAtnlRRDERARLLALAREYGVPVRIVVFEAPEEVLRERLAARARAGGdPSDVPEEVLDRQKARF 140
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
11-183 7.12e-07

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 47.22  E-value: 7.12e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  11 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTgDLLRAEVssgseRGKKLQAIMEKGELVPL--DTVLDMLRDAMVAKADVs 88
Cdd:COG0645     1 LILVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKRL-----FGAGLAPLERSPEATARtyARLLALARELLAAGRSV- 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  89 kgfLIDG---YPREVKQGEEFEKKIAPPTLLLYVDAGKDTMVKRLLKRGETSGRVDDNEETIKKRLETYykatEPVIAFY 165
Cdd:COG0645    74 ---ILDAtflRRAQREAFRALAEEAGAPFVLIWLDAPEEVLRERLEARNAEGGDSDATWEVLERQLAFE----EPLTEDE 146

                         170
                  ....*....|....*...
gi 1751555422 166 KSRGIVRQLNAEGSVEEV 183
Cdd:COG0645   147 GFLLVVDTSGLEEALAAL 164
PRK04182 PRK04182
cytidylate kinase; Provisional
 11-150 5.62e-06

cytidylate kinase; Provisional


Pssm-ID: 235244 [Multi-domain]  Cd Length: 180  Bit Score: 44.80  E-value: 5.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  11 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLR--AEvssgsERGKKLQAIMEKGELVP-LDTVLD-MLRDAMVAKAD 86
Cdd:PRK04182    2 IITISGPPGSGKTTVARLLAEKLGLKHVSAGEIFRelAK-----ERGMSLEEFNKYAEEDPeIDKEIDrRQLEIAEKEDN 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1751555422  87 V---SK--GFLIDGYprevkqgeefekkiapPTLLLYVDAGKDTMVKRLLKRGETSgrVDDNEETIKKR 150
Cdd:PRK04182   77 VvleGRlaGWMAKDY----------------ADLKIWLKAPLEVRAERIAEREGIS--VEEALEETIER 127
PRK01184 PRK01184
flagellar hook-basal body complex protein FliE;
10-150 1.43e-05

flagellar hook-basal body complex protein FliE;


Pssm-ID: 234914 [Multi-domain]  Cd Length: 184  Bit Score: 43.78  E-value: 1.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVVGGPGSGKGtQCEKIVQKYGYTHLSTGDLLRAEVssgSERGkklqaimekgeLVPLDTVLDM----LRD----AM 81
Cdd:PRK01184    2 KIIGVVGMPGSGKG-EFSKIAREMGIPVVVMGDVIREEV---KKRG-----------LEPTDENIGKvaidLRKelgmDA 66

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1751555422  82 VAKADVSK-------GFLIDGYpREVKQGEEFEKKIAPPTLLLYVDAGKDTMVKRLLKRgetsGRVDDNE--ETIKKR 150
Cdd:PRK01184   67 VAKRTVPKirekgdeVVVIDGV-RGDAEVEYFRKEFPEDFILIAIHAPPEVRFERLKKR----GRSDDPKswEELEER 139
CMPK cd02020
Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine ...
 11-54 2.39e-05

Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor.


Pssm-ID: 238978 [Multi-domain]  Cd Length: 147  Bit Score: 42.47  E-value: 2.39e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1751555422  11 IIFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSER 54
Cdd:cd02020     1 IIAIDGPAGSGKSTVAKLLAKKLGLPYLDTGGIRTEEVGKLASE 44
AAA_18 pfam13238
AAA domain;
12-145 8.95e-04

AAA domain;


Pssm-ID: 433052 [Multi-domain]  Cd Length: 128  Bit Score: 37.79  E-value: 8.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  12 IFVVGGPGSGKGTQCEKIVQKYGYTHLSTGDLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRDAMVAKADVSKGF 91
Cdd:pfam13238   1 ILITGTPGVGKTTLAKELSKRLGFGDNVRDLALENGLVLGDDPETRESKRLDEDKLDRLLDLLEENAALEEGGNLIIDGH 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1751555422  92 LIDGYPREVKQGEEFekkiapptlllYVDAGKDTMVKRLLKRGETSGRVDDNEE 145
Cdd:pfam13238  81 LAELEPERAKDLVGI-----------VLRASPEELLERLEKRGYEEAKIKENEE 123
Thymidylate_kin pfam02223
Thymidylate kinase;
16-187 2.96e-03

Thymidylate kinase;


Pssm-ID: 396690  Cd Length: 184  Bit Score: 36.90  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  16 GGPGSGKGTQCEKIVQKYGYTHLSTgdLLRAEVSSGSERGKKLQAIMEKGELVPLDTVLDMLRD-----AMVAKADVSKG 90
Cdd:pfam02223   3 GLDGAGKTTQAELLKERLKEQGIKV--VFTREPGGTPIGEKIRELLLRNEELSPLTEALLFAADriqhlEQKIKPALKQG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  91 FLIDG---------YPREVKQGEEFEKKIAP-----PTLLLYVDAGKDTMVKRLLKRGEtsgrvddNEETIKKRLETYYK 156
Cdd:pfam02223  81 KTVIVdrylfsgiaYQGAKGGDLDLVLSLNPdvpgkPDLTFLLDVDPEVALKRLRRRGE-------LEKTEFEQLDFLRK 153

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1751555422 157 ATEPVIAFYKSRGIVRQLNAEGSVEEVFQQV 187
Cdd:pfam02223 154 VRERYLELAKFDERIKIIDASLSIEEVHEEI 184
Gmk COG0194
Guanylate kinase [Nucleotide transport and metabolism];
110-156 3.37e-03

Guanylate kinase [Nucleotide transport and metabolism];


Pssm-ID: 439964  Cd Length: 190  Bit Score: 36.97  E-value: 3.37e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1751555422 110 IAPPTLllyvdagkDTMVKRLLKRGetsgrvDDNEETIKKRLETYYK 156
Cdd:COG0194   119 ILPPSL--------EELERRLRGRG------TDSEEVIERRLAKARE 151
pseT PHA02530
polynucleotide kinase; Provisional
 10-157 5.88e-03

polynucleotide kinase; Provisional


Pssm-ID: 222856 [Multi-domain]  Cd Length: 300  Bit Score: 36.54  E-value: 5.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1751555422  10 KIIFVVGGPGSGKGTQCEKIVQK-YGYTHLSTGDL---LRAEVSSGSERGKKlqaimEKGELVpldTVldMLRDAMVAKA 85
Cdd:PHA02530    3 KIILTVGVPGSGKSTWAREFAAKnPKAVNVNRDDLrqsLFGHGEWGEYKFTK-----EKEDLV---TK--AQEAAALAAL 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1751555422  86 DVSKGFLIDG---YPREVKQGEEFEKKIAPPTLLLYVDAGKDTMVKRLLKRGETSGRVDdneetIKKRLETYYKA 157
Cdd:PHA02530   73 KSGKSVIISDtnlNPERRRKWKELAKELGAEFEEKVFDVPVEELVKRNRKRGERAVPED-----VLRSMFKQMKE 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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