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Conserved domains on  [gi|1788675128|ref|XP_031792418|]
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ankyrin repeat and MYND domain-containing protein 1 isoform X3 [Piliocolobus tephrosceles]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4642 super family cl34799
Uncharacterized conserved protein [Function unknown];
80-156 1.32e-18

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4642:

Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 86.55  E-value: 1.32e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1788675128  80 QGVQEWQDGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTFYLSHREGYGTMYMKT 156
Cdd:COG4642   185 QGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
375-542 6.54e-18

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.01  E-value: 6.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 375 MALSMIERRKRWQTIKLLLRRGADPNLC-RVPMQVLFLAVKAGDVDGVRLLLEHGArtDICFPPQLGTlTPLHIAAalpg 453
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLEAGADVNARdKDGETPLHLAAYNGNLEIVKLLLEAGA--DVNAQDNDGN-TPLHLAA---- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 454 EEG-VQIVELLLHAITDVDAKasDKDGT--------YKPGKVVKELLTHGADPNLPLTKGlGSALCVACDLtyehqrsvd 524
Cdd:COG0666   162 ANGnLEIVKLLLEAGADVNAR--DNDGEtplhlaaeNGHLEIVKLLLEAGADVNAKDNDG-KTALDLAAEN--------- 229

                         170
                  ....*....|....*...
gi 1788675128 525 DRLALIDRLIDHGADILK 542
Cdd:COG0666   230 GNLEIVKLLLEAGADLNA 247
zf-MYND pfam01753
MYND finger;
656-696 5.93e-09

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 52.04  E-value: 5.93e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1788675128 656 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWnEFHKKDC 696
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
ANKYR super family cl34000
Ankyrin repeat [Signal transduction mechanisms];
162-189 3.26e-03

Ankyrin repeat [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0666:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 40.32  E-value: 3.26e-03
                          10        20
                  ....*....|....*....|....*...
gi 1788675128 162 HCHSAIVNLLLDCGADVNKCSDEGLTAL 189
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-156 1.32e-18

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 86.55  E-value: 1.32e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1788675128  80 QGVQEWQDGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTFYLSHREGYGTMYMKT 156
Cdd:COG4642   185 QGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
375-542 6.54e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.01  E-value: 6.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 375 MALSMIERRKRWQTIKLLLRRGADPNLC-RVPMQVLFLAVKAGDVDGVRLLLEHGArtDICFPPQLGTlTPLHIAAalpg 453
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLEAGADVNARdKDGETPLHLAAYNGNLEIVKLLLEAGA--DVNAQDNDGN-TPLHLAA---- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 454 EEG-VQIVELLLHAITDVDAKasDKDGT--------YKPGKVVKELLTHGADPNLPLTKGlGSALCVACDLtyehqrsvd 524
Cdd:COG0666   162 ANGnLEIVKLLLEAGADVNAR--DNDGEtplhlaaeNGHLEIVKLLLEAGADVNAKDNDG-KTALDLAAEN--------- 229

                         170
                  ....*....|....*...
gi 1788675128 525 DRLALIDRLIDHGADILK 542
Cdd:COG0666   230 GNLEIVKLLLEAGADLNA 247
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 85-150 4.30e-14

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 76.03  E-value: 4.30e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1788675128  85 WQDGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTFYLSHREGYG 150
Cdd:PLN03185   28 WSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLG 93
Ank_2 pfam12796
Ankyrin repeats (3 copies);
388-473 4.26e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 4.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 388 TIKLLLRRGADPNLCRV-PMQVLFLAVKAGDVDGVRLLLEHGARTDicfppQLGTLTPLHIAAalpgEEG-VQIVELLLH 465
Cdd:pfam12796  12 LVKLLLENGADANLQDKnGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                  ....*...
gi 1788675128 466 AITDVDAK 473
Cdd:pfam12796  83 KGADINVK 90
zf-MYND pfam01753
MYND finger;
656-696 5.93e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 52.04  E-value: 5.93e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1788675128 656 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWnEFHKKDC 696
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 374-513 9.81e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 55.27  E-value: 9.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 374 KMALSMIERRKRWQTIKLLLRRGADPN-LCRVPMQVLFLAVKAGDVDGVRLLLEHGARTDIcfPPQLGTlTPLHIAAALP 452
Cdd:PHA02878  169 NTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA--RDKCGN-TPLHISVGYC 245

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1788675128 453 geEGVQIVELLLHAITDVDAKASDKDGT-----YKPGKVVKELLTHGADPNL-------PLTKGLGSALCVAC 513
Cdd:PHA02878  246 --KDYDILKLLLEHGVDVNAKSYILGLTalhssIKSERKLKLLLEYGADINSlnsykltPLSSAVKQYLCINI 316
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 114-136 1.17e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 39.31  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|...
gi 1788675128 114 YHGQFYRDHCHGLGTYVWPDGSS 136
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
113-133 5.93e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.32  E-value: 5.93e-04
                           10        20
                   ....*....|....*....|.
gi 1788675128  113 SYHGQFYRDHCHGLGTYVWPD 133
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
162-189 3.26e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 40.32  E-value: 3.26e-03
                          10        20
                  ....*....|....*....|....*...
gi 1788675128 162 HCHSAIVNLLLDCGADVNKCSDEGLTAL 189
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
 
Name Accession Description Interval E-value
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-156 1.32e-18

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 86.55  E-value: 1.32e-18
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1788675128  80 QGVQEWQDGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTFYLSHREGYGTMYMKT 156
Cdd:COG4642   185 QGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYAD 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
375-542 6.54e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.01  E-value: 6.54e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 375 MALSMIERRKRWQTIKLLLRRGADPNLC-RVPMQVLFLAVKAGDVDGVRLLLEHGArtDICFPPQLGTlTPLHIAAalpg 453
Cdd:COG0666    89 TLLHAAARNGDLEIVKLLLEAGADVNARdKDGETPLHLAAYNGNLEIVKLLLEAGA--DVNAQDNDGN-TPLHLAA---- 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 454 EEG-VQIVELLLHAITDVDAKasDKDGT--------YKPGKVVKELLTHGADPNLPLTKGlGSALCVACDLtyehqrsvd 524
Cdd:COG0666   162 ANGnLEIVKLLLEAGADVNAR--DNDGEtplhlaaeNGHLEIVKLLLEAGADVNAKDNDG-KTALDLAAEN--------- 229

                         170
                  ....*....|....*...
gi 1788675128 525 DRLALIDRLIDHGADILK 542
Cdd:COG0666   230 GNLEIVKLLLEAGADLNA 247
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-155 2.57e-16

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 79.62  E-value: 2.57e-16
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1788675128  80 QGVQEWQDGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTFYLSHREGYGTMYMK 155
Cdd:COG4642   139 GGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYA 214
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-153 1.31e-15

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 77.69  E-value: 1.31e-15
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1788675128  80 QGVQEWQDGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTFYLSHREGYGTMY 153
Cdd:COG4642   162 QGTLTYADGDRYEGEFKNGKRHGQGTLTYANGDVYEGEFKNGQRHGQGTYTYADGDRYEGEFKNGKRHGQGTLT 235
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
375-540 1.62e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 77.69  E-value: 1.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 375 MALSMIERRKRWQTIKLLLRRGADPNLCRVPMQ-VLFLAVKAGDVDGVRLLLEHGArtDICFPPQLGTlTPLHIAAAlpg 453
Cdd:COG0666    56 LLLLAAALAGDLLVALLLLAAGADINAKDDGGNtLLHAAARNGDLEIVKLLLEAGA--DVNARDKDGE-TPLHLAAY--- 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 454 EEGVQIVELLLHAITDVDAKasDKDGT--------YKPGKVVKELLTHGADPNLPLTKGlGSALCVACDltyehqrsvDD 525
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQ--DNDGNtplhlaaaNGNLEIVKLLLEAGADVNARDNDG-ETPLHLAAE---------NG 197

                         170
                  ....*....|....*
gi 1788675128 526 RLALIDRLIDHGADI 540
Cdd:COG0666   198 HLEIVKLLLEAGADV 212
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
376-541 4.68e-15

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 76.53  E-value: 4.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 376 ALSMIERRKRWQTIKLLLRRGADPNLC-RVPMQVLFLAVKAGDVDGVRLLLEHGARTDIcfPPQLGTlTPLHIAAalpgE 454
Cdd:COG0666   123 PLHLAAYNGNLEIVKLLLEAGADVNAQdNDGNTPLHLAAANGNLEIVKLLLEAGADVNA--RDNDGE-TPLHLAA----E 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 455 EG-VQIVELLLHAITDVDAKasDKDG--------TYKPGKVVKELLTHGADPNLPLTKGLGSALCVACDLTYEHQRSVDD 525
Cdd:COG0666   196 NGhLEIVKLLLEAGADVNAK--DNDGktaldlaaENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLL 273

                         170
                  ....*....|....*.
gi 1788675128 526 RLALIDRLIDHGADIL 541
Cdd:COG0666   274 ALLLLAAALLDLLTLL 289
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 85-150 4.30e-14

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 76.03  E-value: 4.30e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1788675128  85 WQDGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTFYLSHREGYG 150
Cdd:PLN03185   28 WSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGTYTGTDGTTYKGRWRLNLKHGLG 93
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-141 5.52e-13

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 69.99  E-value: 5.52e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1788675128  80 QGVQEWQDGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTF 141
Cdd:COG4642   208 QGTYTYADGDRYEGEFKNGKRHGQGTLTYADGDRYEGEFKNGKRHGQGTMTYADGSVYEGEW 269
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
80-153 1.51e-11

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 65.36  E-value: 1.51e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1788675128  80 QGVQEWQDGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTFYLSHREGYGTMY 153
Cdd:COG4642   116 GGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTYADGDRYEGEFKNGKRHGQGTLT 189
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 79-155 8.97e-10

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 62.16  E-value: 8.97e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128  79 VQGVQE------WQDGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTFYLSHREGYGTM 152
Cdd:PLN03185  108 IQGLQEgpgkytWANGNVYLGDMKGGKMSGKGTLTWVSGDSYEGQWLDGMMHGFGVYTWSDGGCYVGTWTRGLKDGKGVF 187


                  ...
gi 1788675128 153 YMK 155
Cdd:PLN03185  188 YPA 190
Ank_2 pfam12796
Ankyrin repeats (3 copies);
388-473 4.26e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 4.26e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 388 TIKLLLRRGADPNLCRV-PMQVLFLAVKAGDVDGVRLLLEHGARTDicfppQLGTLTPLHIAAalpgEEG-VQIVELLLH 465
Cdd:pfam12796  12 LVKLLLENGADANLQDKnGRTALHLAAKNGHLEIVKLLLEHADVNL-----KDNGRTALHYAA----RSGhLEIVKLLLE 82


                  ....*...
gi 1788675128 466 AITDVDAK 473
Cdd:pfam12796  83 KGADINVK 90
zf-MYND pfam01753
MYND finger;
656-696 5.93e-09

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 52.04  E-value: 5.93e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1788675128 656 CYQCGRSiGVRLLPCPRCYGILTCSKYCKTKAWnEFHKKDC 696
Cdd:pfam01753   1 CAVCGKE-ALKLLRCSRCKSVYYCSKECQKADW-PYHKKEC 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
409-499 9.30e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.20  E-value: 9.30e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 409 LFLAVKAGDVDGVRLLLEHGARTDICFPPQlgtLTPLHIAAAlpgEEGVQIVELLLhaiTDVDAKASDKDGT-------Y 481
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNG---RTALHLAAK---NGHLEIVKLLL---EHADVNLKDNGRTalhyaarS 71

                          90
                  ....*....|....*...
gi 1788675128 482 KPGKVVKELLTHGADPNL 499
Cdd:pfam12796  72 GHLEIVKLLLEKGADINV 89
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 374-513 9.81e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 55.27  E-value: 9.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 374 KMALSMIERRKRWQTIKLLLRRGADPN-LCRVPMQVLFLAVKAGDVDGVRLLLEHGARTDIcfPPQLGTlTPLHIAAALP 452
Cdd:PHA02878  169 NTALHYATENKDQRLTELLLSYGANVNiPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA--RDKCGN-TPLHISVGYC 245

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1788675128 453 geEGVQIVELLLHAITDVDAKASDKDGT-----YKPGKVVKELLTHGADPNL-------PLTKGLGSALCVAC 513
Cdd:PHA02878  246 --KDYDILKLLLEHGVDVNAKSYILGLTalhssIKSERKLKLLLEYGADINSlnsykltPLSSAVKQYLCINI 316
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 377-539 1.53e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 51.15  E-value: 1.53e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 377 LSMIERRKRWQTIKLLLRRGADPNLCRVP-MQVLFLAVKAGDVDGVRLLLEHGARTDI--CFppqlgTLTPLHIAAAlpg 453
Cdd:PHA02875  106 LHLATILKKLDIMKLLIARGADPDIPNTDkFSPLHLAVMMGDIKGIELLIDHKACLDIedCC-----GCTPLIIAMA--- 177

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 454 eegvqivelllhaitdvdakasdkdgtYKPGKVVKELLTHGADPNLPLTKGLGSALCVACDltyehqrsvDDRLALIDRL 533
Cdd:PHA02875  178 ---------------------------KGDIAICKMLLDSGANIDYFGKNGCVAALCYAIE---------NNKIDIVRLF 221


                  ....*.
gi 1788675128 534 IDHGAD 539
Cdd:PHA02875  222 IKRGAD 227
COG4642 COG4642
Uncharacterized conserved protein [Function unknown];
75-155 2.61e-06

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443680 [Multi-domain]  Cd Length: 271  Bit Score: 49.57  E-value: 2.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128  75 YLQLVQGVQEWQDGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTFYLSHREGYGTMYM 154
Cdd:COG4642    88 GGDGGGGEGGFGGGGGGGGGKKGGGGGGGGVLEGDDGGGYGGGTADGGRGGGGIYTFPNGDVYEGEFKNGKPHGQGTLTY 167


                  .
gi 1788675128 155 K 155
Cdd:COG4642   168 A 168
PHA03095 PHA03095
ankyrin-like protein; Provisional
 389-540 1.21e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.48  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 389 IKLLLRRGADPN----LCRVPMQVLFLAVKAGDVDGVRLLLEHGARTDIcfpPQLGTLTPLHIAAALPGEEGVqiVELLL 464
Cdd:PHA03095   30 VRRLLAAGADVNfrgeYGKTPLHLYLHYSSEKVKDIVRLLLEAGADVNA---PERCGFTPLHLYLYNATTLDV--IKLLI 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 465 HAITDVDAKasDKDG-----TYKPG-----KVVKELLTHGADPNlpltkglgsalcvACDLtYEHQ------RSVDDRLA 528
Cdd:PHA03095  105 KAGADVNAK--DKVGrtplhVYLSGfninpKVIRLLLRKGADVN-------------ALDL-YGMTplavllKSRNANVE 168

                         170
                  ....*....|..
gi 1788675128 529 LIDRLIDHGADI 540
Cdd:PHA03095  169 LLRLLIDAGADV 180
PLN03185 PLN03185
phosphatidylinositol phosphate kinase; Provisional
 87-156 1.95e-05

phosphatidylinositol phosphate kinase; Provisional


Pssm-ID: 215619 [Multi-domain]  Cd Length: 765  Bit Score: 47.91  E-value: 1.95e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128  87 DGCIYRGEFGLNMKLGYGKFSWPTGESYHGQFYRDHCHGLGTYVWPDGSSFTGTFYLSHREGYGTmYMKT 156
Cdd:PLN03185    7 NGDFYSGSLLGNVPEGPGKYLWSDGCMYEGEWRRGMRHGNGKISWPSGATYEGEFSGGYMHGSGT-YTGT 75
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 372-498 8.14e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.81  E-value: 8.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 372 MRKMALSMIERRKRWQTIKLLLRRGADPN------LCRVPMQVLFLAVKAGDVDGVRLLLEHGARTDICFPPQlgtLTPL 445
Cdd:PHA03100   34 KPVLPLYLAKEARNIDVVKILLDNGADINsstknnSTPLHYLSNIKYNLTDVKEIVKLLLEYGANVNAPDNNG---ITPL 110

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1788675128 446 HIAAALPGEEgVQIVELLLHAITDVDAKASDK--------DGTYKPGKVVKELLTHGADPN 498
Cdd:PHA03100  111 LYAISKKSNS-YSIVEYLLDNGANVNIKNSDGenllhlylESNKIDLKILKLLIDKGVDIN 170
MORN pfam02493
MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple ...
 114-136 1.17e-04

MORN repeat; The MORN (Membrane Occupation and Recognition Nexus) repeat is found in multiple copies in several proteins including junctophilins (See Takeshima et al. Mol. Cell 2000;6:11-22). A MORN-repeat protein has been identified in the parasite Toxoplasma gondiis a dynamic component of cell division apparatus in Toxoplasma gondii. It has been hypothesized to functions as a linker protein between certain membrane regions and the parasite's cytoskeleton.


Pssm-ID: 308220 [Multi-domain]  Cd Length: 23  Bit Score: 39.31  E-value: 1.17e-04
                          10        20
                  ....*....|....*....|...
gi 1788675128 114 YHGQFYRDHCHGLGTYVWPDGSS 136
Cdd:pfam02493   1 YEGEWKNGKRHGKGVYTWPDGDR 23
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 377-540 1.95e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.27  E-value: 1.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 377 LSMIERRKRWQTIKLLLRRGA----DPNLCRVPMQV--LFLAVKAGDVDGVRLLLEHGARTDIcfpPQLGTLTPLHIAAA 450
Cdd:PHA03100    1 LYSYIVLTKSRIIKVKNIKYIimedDLNDYSYKKPVlpLYLAKEARNIDVVKILLDNGADINS---STKNNSTPLHYLSN 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 451 LPG--EEGVQIVELLLHAITDVDAK-----------ASDKDGTYkpgKVVKELLTHGADPNLPLTKGlGSALCVACdlty 517
Cdd:PHA03100   78 IKYnlTDVKEIVKLLLEYGANVNAPdnngitpllyaISKKSNSY---SIVEYLLDNGANVNIKNSDG-ENLLHLYL---- 149

                         170       180
                  ....*....|....*....|...
gi 1788675128 518 ehqRSVDDRLALIDRLIDHGADI 540
Cdd:PHA03100  150 ---ESNKIDLKILKLLIDKGVDI 169
MORN smart00698
Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;
113-133 5.93e-04

Possible plasma membrane-binding motif in junctophilins, PIP-5-kinases and protein kinases;


Pssm-ID: 197832 [Multi-domain]  Cd Length: 22  Bit Score: 37.32  E-value: 5.93e-04
                           10        20
                   ....*....|....*....|.
gi 1788675128  113 SYHGQFYRDHCHGLGTYVWPD 133
Cdd:smart00698   2 RYEGEWRNGKRHGRGVYTYAN 22
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 409-502 6.60e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.67  E-value: 6.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 409 LFLAVKAGDVDGVRLLLEHGARTDICFPpqlGTLTPLHIAAalpgEEG-VQIVELLLHAITDVDakasdkDGTYKPG--- 484
Cdd:PHA02875   39 IKLAMKFRDSEAIKLLMKHGAIPDVKYP---DIESELHDAV----EEGdVKAVEELLDLGKFAD------DVFYKDGmtp 105

                          90       100
                  ....*....|....*....|....*...
gi 1788675128 485 ----------KVVKELLTHGADPNLPLT 502
Cdd:PHA02875  106 lhlatilkklDIMKLLIARGADPDIPNT 133
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 388-499 6.99e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 42.73  E-value: 6.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1788675128 388 TIKLLLRRGADPNLCRV----PMQVLfLAVKAGDVDGVRLLLEHGARTDICFPPqlgTLTPLHIAAALPGEEgVQIVELL 463
Cdd:PHA03100   88 IVKLLLEYGANVNAPDNngitPLLYA-ISKKSNSYSIVEYLLDNGANVNIKNSD---GENLLHLYLESNKID-LKILKLL 162

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1788675128 464 LHAITDVDAKAS--------------DKDG-------TYKPGK-VVKELLTHGADPNL 499
Cdd:PHA03100  163 IDKGVDINAKNRvnyllsygvpinikDVYGftplhyaVYNNNPeFVKYLLDLGANPNL 220
Ank_4 pfam13637
Ankyrin repeats (many copies);
406-464 1.68e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.87  E-value: 1.68e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1788675128 406 MQVLFLAVKAGDVDGVRLLLEHGA---RTDICFppqlgtLTPLHIAAAlpgEEGVQIVELLL 464
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGAdinAVDGNG------ETALHFAAS---NGNVEVLKLLL 54
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
162-189 3.26e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 40.32  E-value: 3.26e-03
                          10        20
                  ....*....|....*....|....*...
gi 1788675128 162 HCHSAIVNLLLDCGADVNKCSDEGLTAL 189
Cdd:COG0666   130 NGNLEIVKLLLEAGADVNAQDNDGNTPL 157
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 443-473 7.02e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 7.02e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1788675128 443 TPLHIAAALPGeeGVQIVELLLHAITDVDAK 473
Cdd:pfam00023   4 TPLHLAAGRRG--NLEIVKLLLSKGADVNAR 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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