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Conserved domains on  [gi|1820979060|ref|XP_032755298|]
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pituitary-specific positive transcription factor 1 isoform X1 [Rattus rattus]

Protein Classification

POU family transcription factor( domain architecture ID 11265437)

POU (Pit-Oct-Unc) family transcription factor binds specific DNA sequences to direct gene expression programs, playing a role in orchestrating embryonic development and directing cellular fate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
150-224 5.60e-46

Found in Pit-Oct-Unc transcription factors;


:

Pssm-ID: 197673  Cd Length: 75  Bit Score: 150.28  E-value: 5.60e-46
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820979060  150 MDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAE 224
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
241-297 5.00e-21

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.47  E-value: 5.00e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1820979060 241 RKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKR 297
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
150-224 5.60e-46

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 150.28  E-value: 5.60e-46
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820979060  150 MDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAE 224
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
153-224 6.76e-40

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 134.33  E-value: 6.76e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820979060 153 PEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAE 224
Cdd:pfam00157   1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
241-297 5.00e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.47  E-value: 5.00e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1820979060 241 RKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKR 297
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 241-299 1.50e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 72.66  E-value: 1.50e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1820979060 241 RKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVK 299
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 240-296 1.78e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.28  E-value: 1.78e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1820979060  240 KRKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREK 296
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
204-297 5.04e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 48.59  E-value: 5.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820979060 204 LSFKNACKLKAILS----KWLEEAEQVGA---LYNEKVGANERKRKRRTTiSIAAKDALERHFGEHSKPSSQEIMRMAEE 276
Cdd:COG5576     9 LSALESQRMPQIRTikttKNKREVEAADSemkLERKQDGSSPPKSKRRRT-TDEQLMVLEREFEINPYPSSITRIKLSLL 87

                          90       100
                  ....*....|....*....|.
gi 1820979060 277 LNLEKEVVRVWFCNRRQREKR 297
Cdd:COG5576    88 LNMPPKSVQIWFQNKRAKEKK 108
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
150-224 5.60e-46

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 150.28  E-value: 5.60e-46
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1820979060  150 MDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAE 224
Cdd:smart00352   1 DDDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
153-224 6.76e-40

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 134.33  E-value: 6.76e-40
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1820979060 153 PEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAE 224
Cdd:pfam00157   1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
241-297 5.00e-21

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 84.47  E-value: 5.00e-21
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1820979060 241 RKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKR 297
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 241-299 1.50e-16

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 72.66  E-value: 1.50e-16
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1820979060 241 RKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVK 299
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 240-296 1.78e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.28  E-value: 1.78e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1820979060  240 KRKRRTTISIAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREK 296
Cdd:smart00389   1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
204-297 5.04e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 48.59  E-value: 5.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1820979060 204 LSFKNACKLKAILS----KWLEEAEQVGA---LYNEKVGANERKRKRRTTiSIAAKDALERHFGEHSKPSSQEIMRMAEE 276
Cdd:COG5576     9 LSALESQRMPQIRTikttKNKREVEAADSemkLERKQDGSSPPKSKRRRT-TDEQLMVLEREFEINPYPSSITRIKLSLL 87

                          90       100
                  ....*....|....*....|.
gi 1820979060 277 LNLEKEVVRVWFCNRRQREKR 297
Cdd:COG5576    88 LNMPPKSVQIWFQNKRAKEKK 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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