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Conserved domains on  [gi|1829483604|ref|XP_033153258|]
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pikachurin [Drosophila mauritiana]

Protein Classification

calcium-binding EGF-like domain-containing protein; LamG domain-containing protein( domain architecture ID 11235619)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions| LamG (Laminin G) domain-containing protein may serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 622-771 1.35e-38

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 141.40  E-value: 1.35e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  622 FNGSSFLRYAPLgDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQW 701
Cdd:cd00110      4 FSGSSYVRLPTL-PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQW 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  702 HTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVGGVNHVDRLPLdLKYKPFFVGCIQRIDIN 771
Cdd:cd00110     83 HSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1202-1337 2.28e-36

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 134.00  E-value: 2.28e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  1202 DLNLRIKTHSENGVILWTGRQGtteeHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLE 1281
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG----GGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLS 76

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1829483604  1282 VDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVLAGE 1337
Cdd:smart00282   77 VDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 401-552 7.66e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 96.33  E-value: 7.66e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  401 RFAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLSGerDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLN 480
Cdd:cd00110      3 SFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAG--SQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDG 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1829483604  481 EWNSVIIYRHRWDAWLVLNHGTKVQGRSNGLFSRITFREPVFLGGIgNITGLAKRLPLAEGFAGCIRRFVAN 552
Cdd:cd00110     81 QWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGL-PEDLKSPGLPVSPGFVGCIRDLKVN 151
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 580-609 5.68e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.99  E-value: 5.68e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1829483604  580 CVRYPCQHGGKCLPSDQGAICLCPIGFVGD 609
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 53-82 1.55e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 1.55e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1829483604   53 CEQLCYEiHDGMYECDCIEGYELNKNGYSC 82
Cdd:pfam14670    8 CSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 622-771 1.35e-38

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 141.40  E-value: 1.35e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  622 FNGSSFLRYAPLgDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQW 701
Cdd:cd00110      4 FSGSSYVRLPTL-PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQW 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  702 HTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVGGVNHVDRLPLdLKYKPFFVGCIQRIDIN 771
Cdd:cd00110     83 HSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1202-1337 2.28e-36

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 134.00  E-value: 2.28e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  1202 DLNLRIKTHSENGVILWTGRQGtteeHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLE 1281
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG----GGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLS 76

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1829483604  1282 VDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVLAGE 1337
Cdd:smart00282   77 VDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1202-1334 4.55e-35

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 131.00  E-value: 4.55e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604 1202 DLNLRIKTHSENGVILWTGRQGtteeHDDYLSLGIEQGYLHFRYDLGSGEVDIRfNGTKVSDGLWHRVRAIRNSQEGYLE 1281
Cdd:cd00110     23 SISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVERNGRSVTLS 97

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1829483604 1282 VDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVL 1334
Cdd:cd00110     98 VDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1207-1337 8.45e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 126.38  E-value: 8.45e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604 1207 IKTHSENGVILWTGRQGTteehdDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRK 1286
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-----DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1829483604 1287 TVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVLAGE 1337
Cdd:pfam02210   76 VVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
642-773 3.83e-33

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 124.76  E-value: 3.83e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604   642 ELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEH-SLSLGQWHTIKISRTARLAVLKVDKH 720
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1829483604   721 QEVLTISSNGFWHLSLDQNLFVGGVNHVDRLPlDLKYKPFFVGCIQRIDINGH 773
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLP-PLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 647-773 4.17e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 121.76  E-value: 4.17e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  647 LKPEQADGLILYSGPeHRGDFIALYLNDGFVEFAFDLGSGPALVRS-EHSLSLGQWHTIKISRTARLAVLKVDKHQEVLT 725
Cdd:pfam02210    1 FRTRQPNGLLLYAGG-GGSDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1829483604  726 ISSNGFWHLSLDQNLFVGGVNHVDRLPLdLKYKPFFVGCIQRIDINGH 773
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPLLLLPA-LPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 401-552 7.66e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 96.33  E-value: 7.66e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  401 RFAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLSGerDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLN 480
Cdd:cd00110      3 SFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAG--SQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDG 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1829483604  481 EWNSVIIYRHRWDAWLVLNHGTKVQGRSNGLFSRITFREPVFLGGIgNITGLAKRLPLAEGFAGCIRRFVAN 552
Cdd:cd00110     81 QWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGL-PEDLKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
421-554 8.74e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 89.71  E-value: 8.74e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604   421 QLRIEFRPESFDGIILLSGERDDltGDFMALLLNKGFVEFWFDCGSGVGSVRSRETIL-LNEWNSVIIYRHRWDAWLVLN 499
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG--GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLnDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1829483604   500 HGTKVQGRSNGLFSRITFREPVFLGGIgNITGLAKRLPLAEGFAGCIRRFVANEH 554
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGL-PEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 426-554 1.04e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 77.85  E-value: 1.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  426 FRPESFDGIILLSGerdDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETIL-LNEWNSVIIYRHRWDAWLVLNHGTKV 504
Cdd:pfam02210    1 FRTRQPNGLLLYAG---GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLnDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1829483604  505 QGRSNGLFSRITFREPVFLGGIgNITGLAKRLPLAEGFAGCIRRFVANEH 554
Cdd:pfam02210   78 SSLPPGESLLLNLNGPLYLGGL-PPLLLLPALPVRAGFVGCIRDVRVNGE 126
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 580-609 5.68e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.99  E-value: 5.68e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1829483604  580 CVRYPCQHGGKCLPSDQGAICLCPIGFVGD 609
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 571-612 6.53e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.53e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1829483604  571 DIQDCSTdkcvRYPCQHGGKCLPSDQGAICLCPIGFVGDLCE 612
Cdd:cd00054      1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 53-82 1.55e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 1.55e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1829483604   53 CEQLCYEiHDGMYECDCIEGYELNKNGYSC 82
Cdd:pfam14670    8 CSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
571-612 1.76e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.76e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1829483604   571 DIQDCSTDkcvrYPCQHGGKCLPSDQGAICLCPIGFV-GDLCE 612
Cdd:smart00179    1 DIDECASG----NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
 
Name Accession Description Interval E-value
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 622-771 1.35e-38

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 141.40  E-value: 1.35e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  622 FNGSSFLRYAPLgDSALIWLELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQW 701
Cdd:cd00110      4 FSGSSYVRLPTL-PAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQW 82

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  702 HTIKISRTARLAVLKVDKHQEVLTISSNGFWHLSLDQNLFVGGVNHVDRLPLdLKYKPFFVGCIQRIDIN 771
Cdd:cd00110     83 HSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPG-LPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1202-1337 2.28e-36

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 134.00  E-value: 2.28e-36
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  1202 DLNLRIKTHSENGVILWTGRQGtteeHDDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLE 1281
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG----GGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLS 76

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1829483604  1282 VDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVLAGE 1337
Cdd:smart00282   77 VDGGNRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPGFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1202-1334 4.55e-35

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 131.00  E-value: 4.55e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604 1202 DLNLRIKTHSENGVILWTGRQGtteeHDDYLSLGIEQGYLHFRYDLGSGEVDIRfNGTKVSDGLWHRVRAIRNSQEGYLE 1281
Cdd:cd00110     23 SISFSFRTTSPNGLLLYAGSQN----GGDFLALELEDGRLVLRYDLGSGSLVLS-SKTPLNDGQWHSVSVERNGRSVTLS 97

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1829483604 1282 VDGRKTVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVL 1334
Cdd:cd00110     98 VDGERVVESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSPGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1207-1337 8.45e-34

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 126.38  E-value: 8.45e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604 1207 IKTHSENGVILWTGRQGTteehdDYLSLGIEQGYLHFRYDLGSGEVDIRFNGTKVSDGLWHRVRAIRNSQEGYLEVDGRK 1286
Cdd:pfam02210    1 FRTRQPNGLLLYAGGGGS-----DFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQT 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1829483604 1287 TVTLRAPGKLRQLNTDTGLYVGGMPDVGYFTHQRYFSGIVGCISEIVLAGE 1337
Cdd:pfam02210   76 VVSSLPPGESLLLNLNGPLYLGGLPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
642-773 3.83e-33

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 124.76  E-value: 3.83e-33
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604   642 ELKVTLKPEQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEH-SLSLGQWHTIKISRTARLAVLKVDKH 720
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1829483604   721 QEVLTISSNGFWHLSLDQNLFVGGVNHVDRLPlDLKYKPFFVGCIQRIDINGH 773
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLP-PLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 647-773 4.17e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 121.76  E-value: 4.17e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  647 LKPEQADGLILYSGPeHRGDFIALYLNDGFVEFAFDLGSGPALVRS-EHSLSLGQWHTIKISRTARLAVLKVDKHQEVLT 725
Cdd:pfam02210    1 FRTRQPNGLLLYAGG-GGSDFLALELVNGRLVLRYDLGSGPESLLSsGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1829483604  726 ISSNGFWHLSLDQNLFVGGVNHVDRLPLdLKYKPFFVGCIQRIDINGH 773
Cdd:pfam02210   80 LPPGESLLLNLNGPLYLGGLPPLLLLPA-LPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
1207-1338 2.07e-29

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 114.34  E-value: 2.07e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604 1207 IKTHSENGVILWTGRQgtteEHDDYLSLGIEQGYLHFRYDLGSGEVDIRFnGTKVSDGLWHRVRAIRNSQEGYLEVDGRK 1286
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQ----TERDFLALELRDGRLEVSYDLGSGAAVVRS-GDKLNDGKWHSVELERNGRSGTLSVDGEA 75

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1829483604 1287 TVTLRAP-GKLRQLNTDTGLYVGGMPDVGYFT-HQRYFSGIVGCISEIVLAGEM 1338
Cdd:pfam00054   76 RPTGESPlGATTDLDVDGPLYVGGLPSLGVKKrRLAISPSFDGCIRDVIVNGKP 129
Laminin_G_1 pfam00054
Laminin G domain;
650-776 8.12e-29

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 112.41  E-value: 8.12e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  650 EQADGLILYSGPEHRGDFIALYLNDGFVEFAFDLGSGPALVRSEHSLSLGQWHTIKISRTARLAVLKVDKHQEVLTISSN 729
Cdd:pfam00054    4 TEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGESPL 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1829483604  730 G-FWHLSLDQNLFVGGVNHVDRLPLDLKYKPFFVGCIQRIDINGHSLG 776
Cdd:pfam00054   84 GaTTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 401-552 7.66e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 96.33  E-value: 7.66e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  401 RFAKRSWLAFPALHGAYKHVQLRIEFRPESFDGIILLSGerDDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLN 480
Cdd:cd00110      3 SFSGSSYVRLPTLPAPRTRLSISFSFRTTSPNGLLLYAG--SQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDG 80

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1829483604  481 EWNSVIIYRHRWDAWLVLNHGTKVQGRSNGLFSRITFREPVFLGGIgNITGLAKRLPLAEGFAGCIRRFVAN 552
Cdd:cd00110     81 QWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGL-PEDLKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
421-554 8.74e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 89.71  E-value: 8.74e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604   421 QLRIEFRPESFDGIILLSGERDDltGDFMALLLNKGFVEFWFDCGSGVGSVRSRETIL-LNEWNSVIIYRHRWDAWLVLN 499
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGG--GDYLALELRDGRLVLRYDLGSGPARLTSDPTPLnDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 1829483604   500 HGTKVQGRSNGLFSRITFREPVFLGGIgNITGLAKRLPLAEGFAGCIRRFVANEH 554
Cdd:smart00282   79 GGNRVSGESPGGLTILNLDGPLYLGGL-PEDLKLPPLPVTPGFRGCIRNLKVNGK 132
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 426-554 1.04e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 77.85  E-value: 1.04e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  426 FRPESFDGIILLSGerdDLTGDFMALLLNKGFVEFWFDCGSGVGSVRSRETIL-LNEWNSVIIYRHRWDAWLVLNHGTKV 504
Cdd:pfam02210    1 FRTRQPNGLLLYAG---GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLnDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1829483604  505 QGRSNGLFSRITFREPVFLGGIgNITGLAKRLPLAEGFAGCIRRFVANEH 554
Cdd:pfam02210   78 SSLPPGESLLLNLNGPLYLGGL-PPLLLLPALPVRAGFVGCIRDVRVNGE 126
Laminin_G_1 pfam00054
Laminin G domain;
426-554 1.47e-16

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 77.36  E-value: 1.47e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1829483604  426 FRPESFDGIILLSGERDDltGDFMALLLNKGFVEFWFDCGSGVGSVRSRETILLNEWNSVIIYRHRWDAWLVLNHGTKVQ 505
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTE--RDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPT 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1829483604  506 GRSN-GLFSRITFREPVFLGGIGNITGLAKRLPLAEGFAGCIRRFVANEH 554
Cdd:pfam00054   79 GESPlGATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGK 128
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 580-609 5.68e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.99  E-value: 5.68e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 1829483604  580 CVRYPCQHGGKCLPSDQGAICLCPIGFVGD 609
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 571-612 6.53e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 6.53e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1829483604  571 DIQDCSTdkcvRYPCQHGGKCLPSDQGAICLCPIGFVGDLCE 612
Cdd:cd00054      1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 53-82 1.55e-04

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 40.30  E-value: 1.55e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1829483604   53 CEQLCYEiHDGMYECDCIEGYELNKNGYSC 82
Cdd:pfam14670    8 CSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 583-612 2.75e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.38  E-value: 2.75e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1829483604  583 YPCQHGGKCLPSDQGAICLCPIGFVGDL-CE 612
Cdd:cd00053      6 NPCSNGGTCVNTPGSYRCVCPPGYTGDRsCE 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
571-612 1.76e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 1.76e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1829483604   571 DIQDCSTDkcvrYPCQHGGKCLPSDQGAICLCPIGFV-GDLCE 612
Cdd:smart00179    1 DIDECASG----NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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