|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
222-467 |
6.19e-146 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 428.81 E-value: 6.19e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTGLVDPKANGCIMADEMGLGKTLQCIALMWTLIKQSPEaGKSTIQKCVIACPSSLVRNWANELV 301
Cdd:cd18067 1 LRPHQREGVKFLYRCVTGRRIRGSHGCIMADEMGLGKTLQCITLMWTLLRQSPQ-CKPEIDKAIVVSPSSLVKNWANELG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDaITPFAIDGKASKEELtQQLRQWSIASGRAVVRPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQTF 381
Cdd:cd18067 80 KWLGGR-LQPLAIDGGSKKEID-RKLVQWASQQGRRVSTPVLIISYETFRLHVEVLQKGEVGLVICDEGHRLKNSDNQTY 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 382 TALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDANGTDKDRKLGDERLSELLTLVN 461
Cdd:cd18067 158 QALDSLNTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILKGRDADASEKERQLGEEKLQELISIVN 237
|
....*.
gi 1832872348 462 KFIIRR 467
Cdd:cd18067 238 RCIIRR 243
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
136-719 |
2.42e-127 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 396.90 E-value: 2.42e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 136 RQGAVFVAKPLHDPAGEFAIVLYDPTVDDKPVTPLEEGEKKTDEPEPPKLDAPLVHKSLADILGLKKKVDERPKVPvvid 215
Cdd:COG0553 160 GRLLLLALLLLALEALLLLGLLLALALLALLELALLAAEAELLLLLELLLELELLAEAAVDAFRLRRLREALESLP---- 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 216 PRLAKVLRPHQVEGVRFLYRCTT-GLvdpkanGCIMADEMGLGKTLQCIALmwtlIKQSPEAGKstIQKCVIACPSSLVR 294
Cdd:COG0553 236 AGLKATLRPYQLEGAAWLLFLRRlGL------GGLLADDMGLGKTIQALAL----LLELKERGL--ARPVLIVAPTSLVG 303
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 295 NWANELVKWLgkDAITPFAIDGKASKEELTQQLRQwsiasgravvRPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLK 374
Cdd:COG0553 304 NWQRELAKFA--PGLRVLVLDGTRERAKGANPFED----------ADLVITSYGLLRRDIELLAAVDWDLVILDEAQHIK 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 375 NDESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDangtdkdrklgdERLS 454
Cdd:COG0553 372 NPATKRAKAVRALKARHRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKGDE------------EALE 439
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 455 ELLTLVNKFIIRRT-NDILsKYLPVKYEHVVFCNLAPFQKDLYNLFIQSpEIRQLLRGKGSQP----LKAINILKKLCNH 529
Cdd:COG0553 440 RLRRLLRPFLLRRTkEDVL-KDLPEKTEETLYVELTPEQRALYEAVLEY-LRRELEGAEGIRRrgliLAALTRLRQICSH 517
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 530 PDLLDlpsdlpgsescfpddfvpkdargRDRDVKSWYSGKMMVLDRMLARIRqDTNDKIVLISNYTQTLDVFDKLCRSRG 609
Cdd:COG0553 518 PALLL-----------------------EEGAELSGRSAKLEALLELLEELL-AEGEKVLVFSQFTDTLDLLEERLEERG 573
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 610 YGCLRLDGTMNVNKRQKLVDKFNDPEGGEfVFLLSSKAGGCGLNLIGANRLVLFDPDWNPAADQQALARVWRDGQKKDCF 689
Cdd:COG0553 574 IEYAYLHGGTSAEERDELVDRFQEGPEAP-VFLISLKAGGEGLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQ 652
|
570 580 590
....*....|....*....|....*....|
gi 1832872348 690 VYRFIATGTIEEKIFQRQSHKSALSSCVVD 719
Cdd:COG0553 653 VYKLVAEGTIEEKILELLEEKRALAESVLG 682
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
222-467 |
2.99e-113 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 344.27 E-value: 2.99e-113
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTGLVDPKANGCIMADEMGLGKTLQCIALMWTLIKQSPeAGKSTIQKCVIACPSSLVRNWANELV 301
Cdd:cd18004 1 LRPHQREGVQFLYDCLTGRRGYGGGGAILADEMGLGKTLQAIALVWTLLKQGP-YGKPTAKKALIVCPSSLVGNWKAEFD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFAIDGKASKEELTQQlrqwsiASGRAVVRPVLIVSYETLRLNVEELKNT-PIGLLLCDEGHRLKNDESQT 380
Cdd:cd18004 80 KWLGLRRIKVVTADGNAKDVKASLD------FFSSASTYPVLIISYETLRRHAEKLSKKiSIDLLICDEGHRLKNSESKT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 381 FTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDANGTDKDRKLGDERLSELLTLV 460
Cdd:cd18004 154 TKALNSLPCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILRSRDPDASEEDKELGAERSQELSELT 233
|
....*..
gi 1832872348 461 NKFIIRR 467
Cdd:cd18004 234 SRFILRR 240
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
225-533 |
6.76e-97 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 303.45 E-value: 6.76e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 225 HQVEGVRFLYRCTTGLVdpkaNGCIMADEMGLGKTLQCIALMWTLIKQSPEAGKSTIqkcvIACPSSLVRNWANELVKWL 304
Cdd:pfam00176 1 YQIEGVNWMLSLENNLG----RGGILADEMGLGKTLQTISLLLYLKHVDKNWGGPTL----IVVPLSLLHNWMNEFERWV 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 305 GKDAITPFAIDGKaskeelTQQLRQWSIASGRAVVRPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQTFTAL 384
Cdd:pfam00176 73 SPPALRVVVLHGN------KRPQERWKNDPNFLADFDVVITTYETLRKHKELLKKVHWHRIVLDEGHRLKNSKSKLSKAL 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 385 NNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGrdangtdkdrkLGDERLSELLTLVNKFI 464
Cdd:pfam00176 147 KSLKTRNRWILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWFDRPIERG-----------GGKKGVSRLHKLLKPFL 215
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1832872348 465 IRRTNDILSKYLPVKYEHVVFCNLAPFQKDLYNLFIQSPEIRQLLRGKG-----SQPLKAINILKKLCNHPDLL 533
Cdd:pfam00176 216 LRRTKKDVEKSLPPKVEYILFCRLSKLQRKLYQTFLLKKDLNAIKTGEGgreikASLLNILMRLRKICNHPGLI 289
|
|
| Rad54_N |
pfam08658 |
Rad54 N terminal; This is the N terminal of the DNA repair protein Rad54. |
31-201 |
2.58e-93 |
|
Rad54 N terminal; This is the N terminal of the DNA repair protein Rad54.
Pssm-ID: 430137 Cd Length: 180 Bit Score: 289.93 E-value: 2.58e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 31 TPQSLDRLVKPFKCPGSATPTRASDKPARKRRKVDYSGADGDVVDG--DKPYTN-EDRLALATRDVNKFPVFKVKDKEST 107
Cdd:pfam08658 1 VPDSLDRLTKPFKVPGSATPTRASDRPARKRRKVSYAGADGDAEDGdsDKPYTNvERRLALATRRVNKFPVFRVKDKETV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 108 FRQRFSVPLKNKDTGAYNAARPAPLLGMRQGAVFVAKPLHDPAGEFAIVLYDPTVDDKPV---TPLEEGEKKTDEPEPP- 183
Cdd:pfam08658 81 FRKSFSVPLKNKKQGAYNPRRPPPTLGTRRGAIFVPRPLHDPTGEFAIVLYDPTVDDRDKpeeEEEAEEEEEEEEPEEKa 160
|
170 180
....*....|....*....|
gi 1832872348 184 --KLDAPLVHKSLADILGLK 201
Cdd:pfam08658 161 rkKLDNPLPHKSLAEILGIK 180
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
222-467 |
3.43e-84 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 268.25 E-value: 3.43e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTGLVDPKANGCIMADEMGLGKTLQCIALMWTLIKQSPEAGKSTIQKCVIACPSSLVRNWANELV 301
Cdd:cd18066 1 LRPHQREGIEFLYECVMGMRVNERFGAILADEMGLGKTLQCISLIWTLLRQGPYGGKPVIKRALIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFAIDGKASKEELTQqlrqwsiasgrAVVRPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQTF 381
Cdd:cd18066 81 KWLGSERIKVFTVDQDHKVEEFIA-----------SPLYSVLIISYEMLLRSLDQISKLNFDLVICDEGHRLKNTSIKTT 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 382 TALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDANGTDKDRKLGDERLSELLTLVN 461
Cdd:cd18066 150 TALTSLSCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVYEEPIVRSREPTATPEEKKLGEARAAELTRLTG 229
|
....*.
gi 1832872348 462 KFIIRR 467
Cdd:cd18066 230 LFILRR 235
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
222-452 |
9.42e-65 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 216.39 E-value: 9.42e-65
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYR--CTTGLVDPKANGCIMADEMGLGKTLQCIALMWTLIKQSPeagksTIQKCVIACPSSLVRNWANE 299
Cdd:cd18007 1 LKPHQVEGVRFLWSnlVGTDVGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAP-----RRSRPLVLCPASTLYNWEDE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 300 LVKWLGKDAITPFAIDGKASKEELTQQLR---QWSIASGravvrpVLIVSYETLR---------------LNVEELKNTP 361
Cdd:cd18007 76 FKKWLPPDLRPLLVLVSLSASKRADARLRkinKWHKEGG------VLLIGYELFRnlasnattdprlkqeFIAALLDPGP 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 362 iGLLLCDEGHRLKNDESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDANG 441
Cdd:cd18007 150 -DLLVLDEGHRLKNEKSQLSKALSKVKTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKFVKPIEAGQCVDS 228
|
250
....*....|.
gi 1832872348 442 TDKDRKLGDER 452
Cdd:cd18007 229 TEEDVRLMLKR 239
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
222-718 |
3.50e-64 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 232.77 E-value: 3.50e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRcttgLVDPKANGcIMADEMGLGKTLQCIALMWTLikqsPEAGKSTIQKCVIAcPSSLVRNWANELV 301
Cdd:PLN03142 170 MRDYQLAGLNWLIR----LYENGING-ILADEMGLGKTLQTISLLGYL----HEYRGITGPHMVVA-PKSTLGNWMNEIR 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLgkDAITPFAIDGKAskEELTQQlRQWSIASGRAvvrPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQTF 381
Cdd:PLN03142 240 RFC--PVLRAVKFHGNP--EERAHQ-REELLVAGKF---DVCVTSFEMAIKEKTALKRFSWRYIIIDEAHRIKNENSLLS 311
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 382 TALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFelpilrgrdANGTDKDRKlgdERLSELLTLVN 461
Cdd:PLN03142 312 KTMRLFSTNYRLLITGTPLQNNLHELWALLNFLLPEIFSSAETFDEWF---------QISGENDQQ---EVVQQLHKVLR 379
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 462 KFIIRRTNDILSKYLPVKYEHVVFCNLAPFQKDLYNLFIQSpEIRQLLRGKGSQPLkaINI---LKKLCNHPDLLDLPSd 538
Cdd:PLN03142 380 PFLLRRLKSDVEKGLPPKKETILKVGMSQMQKQYYKALLQK-DLDVVNAGGERKRL--LNIamqLRKCCNHPYLFQGAE- 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 539 lPGSESCFPDDFVPKdargrdrdvkswySGKMMVLDRMLARIRQdtNDKIVLI-SNYTQTLDVFDKLCRSRGYGCLRLDG 617
Cdd:PLN03142 456 -PGPPYTTGEHLVEN-------------SGKMVLLDKLLPKLKE--RDSRVLIfSQMTRLLDILEDYLMYRGYQYCRIDG 519
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 618 TMNVNKRQKLVDKFNDPEGGEFVFLLSSKAGGCGLNLIGANRLVLFDPDWNPAADQQALARVWRDGQKKDCFVYRFIATG 697
Cdd:PLN03142 520 NTGGEDRDASIDAFNKPGSEKFVFLLSTRAGGLGINLATADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQVFRFCTEY 599
|
490 500
....*....|....*....|.
gi 1832872348 698 TIEEKIFQRQSHKSALSSCVV 718
Cdd:PLN03142 600 TIEEKVIERAYKKLALDALVI 620
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
222-419 |
4.79e-59 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 198.56 E-value: 4.79e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTtglvdPKANGCIMADEMGLGKTLQCIALMWTLIKQSPEAGKstiqkCVIACPSSLVRNWANELV 301
Cdd:cd17919 1 LRPYQLEGLNFLLELY-----ENGPGGILADEMGLGKTLQAIAFLAYLLKEGKERGP-----VLVVCPLSVLENWEREFE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKdaITPFAIDGkASKEELTQQLRQWSIASGravvrpVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQTF 381
Cdd:cd17919 71 KWTPD--LRVVVYHG-SQRERAQIRAKEKLDKFD------VVLTTYETLRRDKASLRKFRWDLVVVDEAHRLKNPKSQLS 141
|
170 180 190
....*....|....*....|....*....|....*...
gi 1832872348 382 TALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYL 419
Cdd:cd17919 142 KALKALRAKRRLLLTGTPLQNNLEELWALLDFLDPPFL 179
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
222-467 |
3.06e-58 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 198.76 E-value: 3.06e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCttgLVDPKanGCIMADEMGLGKTLQCIALMWTLIKQS--------------PEAGKSTIQKCV-I 286
Cdd:cd18005 1 LRDYQREGVEFMYDL---YKNGR--GGILGDDMGLGKTVQVIAFLAAVLGKTgtrrdrennrprfkKKPPASSAKKPVlI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 287 ACPSSLVRNWANELVKWlGKDAITPFAIDGKasKEELtqqlrQWSIASGRAvvrPVLIVSYETLRLNVEELKNTPIGLLL 366
Cdd:cd18005 76 VAPLSVLYNWKDELDTW-GHFEVGVYHGSRK--DDEL-----EGRLKAGRL---EVVVTTYDTLRRCIDSLNSINWSAVI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 367 CDEGHRLKNDESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDANGTDKDR 446
Cdd:cd18005 145 ADEAHRIKNPKSKLTQAMKELKCKVRIGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHFSEPIKRGQRHTATAREL 224
|
250 260
....*....|....*....|.
gi 1832872348 447 KLGDERLSELLTLVNKFIIRR 467
Cdd:cd18005 225 RLGRKRKQELAVKLSKFFLRR 245
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
566-694 |
1.62e-56 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 190.00 E-value: 1.62e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 566 YSGKMMVLDRMLARIRqDTNDKIVLISNYTQTLDVFDKLCRSRGYGCLRLDGTMNVNKRQKLVDKFNDPEGgEFVFLLSS 645
Cdd:cd18793 9 VSGKLEALLELLEELR-EPGEKVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPD-IRVFLLST 86
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1832872348 646 KAGGCGLNLIGANRLVLFDPDWNPAADQQALARVWRDGQKKDCFVYRFI 694
Cdd:cd18793 87 KAGGVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
222-468 |
5.91e-51 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 177.76 E-value: 5.91e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYR-CTTGLvdpkanGCIMADEMGLGKTLQCIALMwTLIKQSPEAGKStiqkcVIACPSSLVRNWANEL 300
Cdd:cd18012 5 LRPYQKEGFNWLSFlRHYGL------GGILADDMGLGKTLQTLALL-LSRKEEGRKGPS-----LVVAPTSLIYNWEEEA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 301 VKWlgkdaiTP----FAIDGKASKEELTQQLRQwsiasgravvRPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKND 376
Cdd:cd18012 73 AKF------APelkvLVIHGTKRKREKLRALED----------YDLVITSYGLLRRDIELLKEVKFHYLVLDEAQNIKNP 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 377 ESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDAngtdkdrklgdERLSEL 456
Cdd:cd18012 137 QTKTAKAVKALKADHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRFAKPIEKDGDE-----------EALEEL 205
|
250
....*....|..
gi 1832872348 457 LTLVNKFIIRRT 468
Cdd:cd18012 206 KKLISPFILRRL 217
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
222-467 |
3.05e-49 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 173.33 E-value: 3.05e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYrcttGLVDPKANGcIMADEMGLGKTLQCIALMWTLikqspeAGKSTIQKCVIACPSSLVRNWANELV 301
Cdd:cd18001 1 LYPHQREGVAWLW----SLHDGGKGG-ILADDMGLGKTVQICAFLSGM------FDSGLIKSVLVVMPTSLIPHWVKEFA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWlgKDAITPFAIDGkASKEELTQQLRqwSIASGRAVvrpvLIVSYETLRLNVEELKNTPIG-----LLLCDEGHRLKND 376
Cdd:cd18001 70 KW--TPGLRVKVFHG-TSKKERERNLE--RIQRGGGV----LLTTYGMVLSNTEQLSADDHDefkwdYVILDEGHKIKNS 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 377 ESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFA-NPNYLGTKNEFRKRFELPILRGRDANGTDKDRKLGDERLSE 455
Cdd:cd18001 141 KTKSAKSLREIPAKNRIILTGTPIQNNLKELWALFDFAcNGSLLGTRKTFKMEFENPITRGRDKDATQGEKALGSEVAEN 220
|
250
....*....|..
gi 1832872348 456 LLTLVNKFIIRR 467
Cdd:cd18001 221 LRQIIKPYFLRR 232
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
222-467 |
7.07e-47 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 166.76 E-value: 7.07e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrctTGLVDPKANGcIMADEMGLGKTLQCIALMWTLIKQSPEAGKSTIQKCVIACPSSLVRNWANELV 301
Cdd:cd17999 1 LRPYQQEGINWL----AFLNKYNLHG-ILCDDMGLGKTLQTLCILASDHHKRANSFNSENLPSLVVCPPTLVGHWVAEIK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFAIDGKAskeeltQQLRQWSIASGRAvvrPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQTF 381
Cdd:cd17999 76 KYFPNAFLKPLAYVGPP------QERRRLREQGEKH---NVIVASYDVLRNDIEVLTKIEWNYCVLDEGHIIKNSKTKLS 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 382 TALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDANGTDKDRKLGDERLSELLTLVN 461
Cdd:cd17999 147 KAVKQLKANHRLILSGTPIQNNVLELWSLFDFLMPGYLGTEKQFQRRFLKPILASRDSKASAKEQEAGALALEALHKQVL 226
|
....*.
gi 1832872348 462 KFIIRR 467
Cdd:cd17999 227 PFLLRR 232
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
222-452 |
1.69e-46 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 166.22 E-value: 1.69e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTGLVDPK----ANGCIMADEMGLGKTLQCIALMWTLIKQSPEAGKSTIqkcVIACPSSLVRNWA 297
Cdd:cd18068 1 LKPHQVDGVQFMWDCCCESLKKTkkspGSGCILAHCMGLGKTLQVVTFLHTVLLCEKLENFSRV---LVVCPLNTVLNWL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 298 NELVKWL----GKDAITPFAIDGKASKEELTQQLRQWSIASGravvrpVLIVSYETLRLNVEE----------------L 357
Cdd:cd18068 78 NEFEKWQeglkDEEKIEVNELATYKRPQERSYKLQRWQEEGG------VMIIGYDMYRILAQErnvksreklkeifnkaL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 358 KNTPIGLLLCDEGHRLKNDESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGR 437
Cdd:cd18068 152 VDPGPDFVVCDEGHILKNEASAVSKAMNSIRTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVNPIQNGQ 231
|
250
....*....|....*
gi 1832872348 438 DANGTDKDRKLGDER 452
Cdd:cd18068 232 CADSTLVDVRVMKKR 246
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
222-452 |
1.87e-45 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 162.68 E-value: 1.87e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLY----RCTTGLVDPKANGCIMADEMGLGKTLQCIALMWTLIKQSPeagkstIQKCVIACPSSLVRNWA 297
Cdd:cd18069 1 LKPHQIGGIRFLYdniiESLERYKGSSGFGCILAHSMGLGKTLQVISFLDVLLRHTG------AKTVLAIVPVNTLQNWL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 298 NELVKWL------GKDAITPFAI----DGKASKEELTQQLRQWSIASGravvrpVLIVSYETLRLnveelKNTPiGLLLC 367
Cdd:cd18069 75 SEFNKWLpppealPNVRPRPFKVfilnDEHKTTAARAKVIEDWVKDGG------VLLMGYEMFRL-----RPGP-DVVIC 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 368 DEGHRLKNDESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDANGTDKDRK 447
Cdd:cd18069 143 DEGHRIKNCHASTSQALKNIRSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCVDSTPQDVK 222
|
....*
gi 1832872348 448 LGDER 452
Cdd:cd18069 223 LMRYR 227
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
222-467 |
4.75e-36 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 135.64 E-value: 4.75e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTGlvdpkANGCIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd18006 1 LRPYQLEGVNWLLQCRAE-----QHGCILGDEMGLGKTCQTISLLWYLAGRLKLLGPF-----LVLCPLSVLDNWKEELN 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFAIDgKASKEELTQQLRQWSIASgravvrpVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQTF 381
Cdd:cd18006 71 RFAPDLSVITYMGD-KEKRLDLQQDIKSTNRFH-------VLLTTYEICLKDASFLKSFPWASLVVDEAHRLKNQNSLLH 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 382 TALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLG--TKNEFRKRFelpilrgrdangtdKDRKLGDERLSELLTL 459
Cdd:cd18006 143 KTLSEFSVDFRLLLTGTPIQNSLQELYALLSFIEPNVFPkdKLDDFIKAY--------------SETDDESETVEELHLL 208
|
....*...
gi 1832872348 460 VNKFIIRR 467
Cdd:cd18006 209 LQPFLLRR 216
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
221-467 |
1.94e-35 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 134.44 E-value: 1.94e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 221 VLRPHQVEGVRFLYRcttgLVDPKANGcIMADEMGLGKTLQCIALMWTLIkqspEAGksTIQKCVIACPSSLVRNWANEL 300
Cdd:cd18009 3 VMRPYQLEGMEWLRM----LWENGING-ILADEMGLGKTIQTIALLAHLR----ERG--VWGPFLVIAPLSTLPNWVNEF 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 301 VKWlgkdaiTPF--AIDGKASKEELTQQLRQWSIASGRAVVRPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDES 378
Cdd:cd18009 72 ARF------TPSvpVLLYHGTKEERERLRKKIMKREGTLQDFPVVVTSYEIAMRDRKALQHYAWKYLIVDEGHRLKNLNC 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 379 QTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDANGTDKDRKLGDERLSELLT 458
Cdd:cd18009 146 RLIQELKTFNSDNRLLLTGTPLQNNLSELWSLLNFLLPDVFDDLSSFESWFDFSSLSDNAADISNLSEEREQNIVHMLHA 225
|
....*....
gi 1832872348 459 LVNKFIIRR 467
Cdd:cd18009 226 ILKPFLLRR 234
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
222-429 |
5.39e-33 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 126.98 E-value: 5.39e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTglvdpKANGCIMADEMGLGKTLQCIALMWTLIKQSPEAGKSTiqkcVIAcPSSLVRNWANELV 301
Cdd:cd17995 1 LRDYQLEGVNWLLFNWY-----NRRNCILADEMGLGKTIQSIAFLEHLYQVEGIRGPFL----VIA-PLSTIPNWQREFE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFaiDGKASKEELTQQLRQWSIASGRAVVRP----VLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDE 377
Cdd:cd17995 71 TWTDMNVVVYH--GSGESRQIIQQYEMYFKDAQGRKKKGVykfdVLITTYEMVIADAEELRKIPWRVVVVDEAHRLKNRN 148
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1832872348 378 SQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRF 429
Cdd:cd17995 149 SKLLQGLKKLTLEHKLLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEF 200
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
222-467 |
2.97e-32 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 125.48 E-value: 2.97e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYrcttglvdpkANGCIMADEMGLGKTLQCIALM-----WTLIKQSPEAGKSTIQKCV-------IACP 289
Cdd:cd18008 1 LLPYQKQGLAWML----------PRGGILADEMGLGKTIQALALIlatrpQDPKIPEELEENSSDPKKLylskttlIVVP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 290 SSLVRNWANELVKWLGKDAITPFAIDGkASKEELTQQLRQWSIasgravvrpvLIVSYETLR--------LNVEELKNTP 361
Cdd:cd18008 71 LSLLSQWKDEIEKHTKPGSLKVYVYHG-SKRIKSIEELSDYDI----------VITTYGTLAsefpknkkGGGRDSKEKE 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 362 IGLLLC--------DEGHRLKNDESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPI 433
Cdd:cd18008 140 ASPLHRirwyrvilDEAHNIKNRSTKTSRAVCALKAERRWCLTGTPIQNSLDDLYSLLRFLRVEPFGDYPWFNSDISKPF 219
|
250 260 270
....*....|....*....|....*....|....
gi 1832872348 434 LRGRDANGtdkdrklgdERLSELLtlvNKFIIRR 467
Cdd:cd18008 220 SKNDRKAL---------ERLQALL---KPILLRR 241
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
222-467 |
2.95e-31 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 121.69 E-value: 2.95e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTglvdpKANGCIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd17993 2 LRDYQLTGLNWLAHSWC-----KGNNGILADEMGLGKTVQTISFLSYLFHSQQQYGPF-----LVVVPLSTMPAWQREFA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLgkDAITPFAIDGKASKEELTQQLrQWSIASGRAVVRPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQTF 381
Cdd:cd17993 72 KWA--PDMNVIVYLGDIKSRDTIREY-EFYFSQTKKLKFNVLLTTYEIILKDKAFLGSIKWQYLAVDEAHRLKNDESLLY 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 382 TALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNylgtKNEFRKRFELPilrgrdangTDKDRKLGDERLSELLtlvN 461
Cdd:cd17993 149 EALKEFKTNNRLLITGTPLQNSLKELWALLHFLMPG----KFDIWEEFEEE---------HDEEQEKGIADLHKEL---E 212
|
....*.
gi 1832872348 462 KFIIRR 467
Cdd:cd17993 213 PFILRR 218
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
222-467 |
4.09e-31 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 121.69 E-value: 4.09e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrctTGLVDPKANGcIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd18003 1 LREYQHIGLDWL----ATLYEKNLNG-ILADEMGLGKTIQTIALLAHLACEKGNWGPH-----LIVVPTSVMLNWEMEFK 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWL-GKDAITPFAidgkaSKEELTQQLRQWSiasgravvRP----VLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKND 376
Cdd:cd18003 71 RWCpGFKILTYYG-----SAKERKLKRQGWM--------KPnsfhVCITSYQLVVQDHQVFKRKKWKYLILDEAHNIKNF 137
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 377 ESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPiLRGRDANGTDKDRKLgderLSEL 456
Cdd:cd18003 138 KSQRWQTLLNFNTQRRLLLTGTPLQNSLMELWSLMHFLMPHIFQSHQEFKEWFSNP-LTAMSEGSQEENEEL----VRRL 212
|
250
....*....|.
gi 1832872348 457 LTLVNKFIIRR 467
Cdd:cd18003 213 HKVLRPFLLRR 223
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
222-419 |
1.38e-30 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 118.97 E-value: 1.38e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRcttgLVDPKANGcIMADEMGLGKTLQCIALMWTLiKQSPEAGKSTIqkcvIACPSSLVRNWANELV 301
Cdd:cd18000 1 LFKYQQTGVQWLWE----LHCQRVGG-ILGDEMGLGKTIQIIAFLAAL-HHSKLGLGPSL----IVCPATVLKQWVKEFH 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFAIDGKASKEELTQQLRQWSIASGRAVVRP--VLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQ 379
Cdd:cd18000 71 RWWPPFRVVVLHSSGSGTGSEEKLGSIERKSQLIRKVVGDggILITTYEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAE 150
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 1832872348 380 TFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYL 419
Cdd:cd18000 151 ITLACKQLRTPHRLILSGTPIQNNLKELWSLFDFVFPPYL 190
|
|
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
222-467 |
8.26e-30 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 117.69 E-value: 8.26e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFlyrcttGLvdpKANG-CIMADEMGLGKTLQCIALMWTLIKQSPeagkstiqkCVIACPSSLVRNWANEL 300
Cdd:cd18010 1 LLPFQREGVCF------AL---RRGGrVLIADEMGLGKTVQAIAIAAYYREEWP---------LLIVCPSSLRLTWADEI 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 301 VKWLGKDAITPFAIdgkaskeeltqqlrqwsIASGRAVVRP----VLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKND 376
Cdd:cd18010 63 ERWLPSLPPDDIQV-----------------IVKSKDGLRDgdakVVIVSYDLLRRLEKQLLARKFKVVICDESHYLKNS 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 377 ESQTFTALNNLNVQ-KRVI-LSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPIL--RGRDANGTdkdrklgdER 452
Cdd:cd18010 126 KAKRTKAALPLLKRaKRVIlLSGTPALSRPIELFTQLDALDPKLFGRFHDFGRRYCAAKQggFGWDYSGS--------SN 197
|
250
....*....|....*.
gi 1832872348 453 LSELLTLVNK-FIIRR 467
Cdd:cd18010 198 LEELHLLLLAtIMIRR 213
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
222-468 |
4.08e-29 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 115.88 E-value: 4.08e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrctTGLVDPKANGcIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd17997 4 MRDYQIRGLNWL----ISLFENGING-ILADEMGLGKTLQTISLLGYLKHYKNINGPH-----LIIVPKSTLDNWMREFK 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKdaitPFAIDGKASKEELTQQLRQwsiasgRAVVRP--VLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQ 379
Cdd:cd17997 74 RWCPS----LRVVVLIGDKEERADIIRD------VLLPGKfdVCITSYEMVIKEKTVLKKFNWRYIIIDEAHRIKNEKSK 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 380 TFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFElpilrgrdangTDKDRKLGDERLSELLTL 459
Cdd:cd17997 144 LSQIVRLFNSRNRLLLTGTPLQNNLHELWALLNFLLPDVFTSSEDFDEWFN-----------VNNCDDDNQEVVQRLHKV 212
|
....*....
gi 1832872348 460 VNKFIIRRT 468
Cdd:cd17997 213 LRPFLLRRI 221
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
222-476 |
2.42e-28 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 114.00 E-value: 2.42e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrctTGLVDPKANGcIMADEMGLGKTLQCIALMWTLIKQspeagKSTIQKCVIACPSSLVRNWANELV 301
Cdd:cd17996 4 LKEYQLKGLQWM----VSLYNNNLNG-ILADEMGLGKTIQTISLITYLMEK-----KKNNGPYLVIVPLSTLSNWVSEFE 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKdaITPFAIDG-KASKEELTQQLR--QWSiasgravvrpVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDES 378
Cdd:cd17996 74 KWAPS--VSKIVYKGtPDVRKKLQSQIRagKFN----------VLLTTYEYIIKDKPLLSKIKWKYMIIDEGHRMKNAQS 141
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 379 QTFTALNN-LNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPIlrgrdANGTDKDrklgDERLSELL 457
Cdd:cd17996 142 KLTQTLNTyYHARYRLLLTGTPLQNNLPELWALLNFLLPKIFKSCKTFEQWFNTPF-----ANTGEQV----KIELNEEE 212
|
250
....*....|....*....
gi 1832872348 458 TLVnkfIIRRTNDILSKYL 476
Cdd:cd17996 213 TLL---IIRRLHKVLRPFL 228
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
222-450 |
1.26e-27 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 110.61 E-value: 1.26e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTGLVDpkangCIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd17994 1 LHPYQLEGLNWLRFSWAQGTD-----TILADEMGLGKTIQTIVFLYSLYKEGHSKGPF-----LVSAPLSTIINWEREFE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFAIDGkaskeeltqqlrqwsiasgravvrpVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQTF 381
Cdd:cd17994 71 MWAPDFYVVTYVGDH-------------------------VLLTSYELISIDQAILGSIDWAVLVVDEAHRLKNNQSKFF 125
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1832872348 382 TALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFElpilrgrDANGTDKDRKLGD 450
Cdd:cd17994 126 RILNSYKIGYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLQGFLEEFA-------DISKEDQIKKLHD 187
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
222-450 |
5.76e-27 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 110.15 E-value: 5.76e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTGLVDpkangCIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd18057 1 LHPYQLEGLNWLRFSWAQGTD-----TILADEMGLGKTVQTIVFLYSLYKEGHSKGPY-----LVSAPLSTIINWEREFE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFAIDgKASKEELTQQ---LRQWSIASGRAVVR---------PVLIVSYETLRLNVEELKNTPIGLLLCDE 369
Cdd:cd18057 71 MWAPDFYVVTYTGD-KESRSVIRENefsFEDNAIRSGKKVFRmkkeaqikfHVLLTSYELITIDQAILGSIEWACLVVDE 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 370 GHRLKNDESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFElpilrgrDANGTDKDRKLG 449
Cdd:cd18057 150 AHRLKNNQSKFFRVLNSYKIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA-------DISKEDQIKKLH 222
|
.
gi 1832872348 450 D 450
Cdd:cd18057 223 D 223
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
222-417 |
3.83e-26 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 106.32 E-value: 3.83e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrcttGLVDPKANGCIMADEMGLGKTLQCIALMwTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd17998 1 LKDYQLIGLNWL-----NLLYQKKLSGILADEMGLGKTIQVIAFL-AYLKEIGIPGPH-----LVVVPSSTLDNWLREFK 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFaidgKASKEElTQQLRQwsIASGRAVVRPVLIVSYETLRLNVEE---LKNTPIGLLLCDEGHRLKNDES 378
Cdd:cd17998 70 RWCPSLKVEPY----YGSQEE-RKHLRY--DILKGLEDFDVIVTTYNLATSNPDDrsfFKRLKLNYVVYDEGHMLKNMTS 142
|
170 180 190
....*....|....*....|....*....|....*....
gi 1832872348 379 QTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPN 417
Cdd:cd17998 143 ERYRHLMTINANFRLLLTGTPLQNNLLELMSLLNFIMPK 181
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
222-450 |
1.48e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 105.92 E-value: 1.48e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTGLVDpkangCIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd18056 1 LHPYQLEGLNWLRFSWAQGTD-----TILADEMGLGKTVQTAVFLYSLYKEGHSKGPF-----LVSAPLSTIINWEREFE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFA--IDGKASKEELTQQLRQWSIASGRAVVR---------PVLIVSYETLRLNVEELKNTPIGLLLCDEG 370
Cdd:cd18056 71 MWAPDMYVVTYVgdKDSRAIIRENEFSFEDNAIRGGKKASRmkkeasvkfHVLLTSYELITIDMAILGSIDWACLIVDEA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 371 HRLKNDESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFElpilrgrDANGTDKDRKLGD 450
Cdd:cd18056 151 HRLKNNQSKFFRVLNGYSLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFA-------DIAKEDQIKKLHD 223
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
222-429 |
1.49e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 105.52 E-value: 1.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFL----YrcttglvdpKANGCIMADEMGLGKTLQCIAL---MWTLIKQSPeagkstiqkCVIACPSSLVR 294
Cdd:cd18060 1 LREYQLEGVNWLlfnwY---------NRQNCILADEMGLGKTIQSIAFlqeVYNVGIHGP---------FLVIAPLSTIT 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 295 NWANELVKWLGKDAITpfaIDGKASKEELTQQLRQWSIAS-GR----AVVRPVLIVSYETLRLNVEELKNTPIGLLLCDE 369
Cdd:cd18060 63 NWEREFNTWTEMNTIV---YHGSLASRQMIQQYEMYCKDSrGRlipgAYKFDALITTFEMILSDCPELREIEWRCVIIDE 139
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 370 GHRLKNDESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRF 429
Cdd:cd18060 140 AHRLKNRNCKLLDSLKHMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDF 199
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
568-683 |
3.46e-25 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 100.75 E-value: 3.46e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 568 GKMMVLDRMLariRQDTNDKIVLISNYTQTLDvFDKLCRSRGYGCLRLDGTMNVNKRQKLVDKFNDpegGEFVFLLSSKA 647
Cdd:pfam00271 1 EKLEALLELL---KKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRK---GKIDVLVATDV 73
|
90 100 110
....*....|....*....|....*....|....*.
gi 1832872348 648 GGCGLNLIGANRLVLFDPDWNPAADQQALARVWRDG 683
Cdd:pfam00271 74 AERGLDLPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
222-467 |
4.75e-25 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 104.51 E-value: 4.75e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrctTGLVDPKANGcIMADEMGLGKTLQCIALMWTLIKQspeagKSTIQKCVIACPSSLVRNWANELV 301
Cdd:cd18002 1 LKEYQLKGLNWL----ANLYEQGING-ILADEMGLGKTVQSIAVLAHLAEE-----HNIWGPFLVIAPASTLHNWQQEIS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFAidGKASKEELTQQLRQWSIASGRAVVRPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQTF 381
Cdd:cd18002 71 RFVPQFKVLPYW--GNPKDRKVLRKFWDRKNLYTRDAPFHVVITSYQLVVQDEKYFQRVKWQYMVLDEAQAIKSSSSSRW 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 382 TALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDANGtdkdrKLGDERLSELLTLVN 461
Cdd:cd18002 149 KTLLSFHCRNRLLLTGTPIQNSMAELWALLHFIMPTLFDSHDEFNEWFSKDIESHAENKT-----GLNEHQLKRLHMILK 223
|
....*.
gi 1832872348 462 KFIIRR 467
Cdd:cd18002 224 PFMLRR 229
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
222-450 |
7.82e-25 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 103.94 E-value: 7.82e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTGLVDpkangCIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd18055 1 LHMYQLEGLNWLRFSWAQGTD-----TILADEMGLGKTIQTIVFLYSLYKEGHTKGPF-----LVSAPLSTIINWEREFQ 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFA--IDGKASKEELTQQLRQWSIASGRAVVR---------PVLIVSYETLRLNVEELKNTPIGLLLCDEG 370
Cdd:cd18055 71 MWAPDFYVVTYTgdKDSRAIIRENEFSFDDNAVKGGKKAFKmkreaqvkfHVLLTSYELVTIDQAALGSIRWACLVVDEA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 371 HRLKNDESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFElpilrgrDANGTDKDRKLGD 450
Cdd:cd18055 151 HRLKNNQSKFFRVLNGYKIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA-------DISKEDQIKKLHD 223
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
222-426 |
1.07e-24 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 102.75 E-value: 1.07e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrcttglVDPKANGCIMADEMGLGKTLQciALMwtLIKQSpeAGKSTIQKCVIACPSSLVRNWANELv 301
Cdd:cd18011 1 PLPHQIDAVLRA-------LRKPPVRLLLADEVGLGKTIE--AGL--IIKEL--LLRGDAKRVLILCPASLVEQWQDEL- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 kwLGKDAITPFAIDGKASKEELTQQLRQWsiasgraVVRPVLIVSYETLRLNVEE---LKNTPIGLLLCDEGHRLKN--- 375
Cdd:cd18011 67 --QDKFGLPFLILDRETAAQLRRLIGNPF-------EEFPIVIVSLDLLKRSEERrglLLSEEWDLVVVDEAHKLRNsgg 137
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1832872348 376 -DESQTFTALNNL--NVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFR 426
Cdd:cd18011 138 gKETKRYKLGRLLakRARHVLLLTATPHNGKEEDFRALLSLLDPGRFAVLGRFL 191
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
214-413 |
4.85e-24 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 100.64 E-value: 4.85e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 214 IDPRLAKVLRPHQVEGVRFLYRCTtglvdpkaNGCIMADEMGLGKTLQ-CIALMWTLIKQSPeagkstiQKCVIACP-SS 291
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGL--------RDVILAAPTGSGKTLAaLLPALEALKRGKG-------GRVLVLVPtRE 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 292 LVRNWANELVKWLGKDAITPFAIDGKASKEELTQQLRqwsiaSGRAvvrPVLIVSYETLRLNVEE--LKNTPIGLLLCDE 369
Cdd:smart00487 66 LAEQWAEELKKLGPSLGLKVVGLYGGDSKREQLRKLE-----SGKT---DILVTTPGRLLDLLENdkLSLSNVDLVILDE 137
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1832872348 370 GHRLKND--ESQTFTALNNLNVQKRVI-LSGTP---IQNDLSEYFALLNF 413
Cdd:smart00487 138 AHRLLDGgfGDQLEKLLKLLPKNVQLLlLSATPpeeIENLLELFLNDPVF 187
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
222-441 |
2.55e-23 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 99.69 E-value: 2.55e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYR--CttglvdpKANGCIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANE 299
Cdd:cd18054 21 LRDYQLEGLNWLAHswC-------KNNSVILADEMGLGKTIQTISFLSYLFHQHQLYGPF-----LLVVPLSTLTSWQRE 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 300 LVKWLGKDAITPFAIDGKASKeelTQQLRQWSIASGRAVVRPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQ 379
Cdd:cd18054 89 FEIWAPEINVVVYIGDLMSRN---TIREYEWIHSQTKRLKFNALITTYEILLKDKTVLGSINWAFLGVDEAHRLKNDDSL 165
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1832872348 380 TFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNylgtKNEFRKRFELPILRGRDaNG 441
Cdd:cd18054 166 LYKTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPE----KFEFWEDFEEDHGKGRE-NG 222
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
222-429 |
5.63e-23 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 98.18 E-value: 5.63e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTglvdpKANGCIMADEMGLGKTLQCIALMWTLIKqspeagKSTIQKCVIACPSSLVRNWANELV 301
Cdd:cd18059 1 LREYQLEGVNWLLFNWY-----NTRNCILADEMGLGKTIQSITFLYEIYL------KGIHGPFLVIAPLSTIPNWEREFR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFAidGKASKEELTQQLRQWSIASGRAVVRP----VLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDE 377
Cdd:cd18059 70 TWTELNVVVYHG--SQASRRTIQLYEMYFKDPQGRVIKGSykfhAIITTFEMILTDCPELRNIPWRCVVIDEAHRLKNRN 147
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 1832872348 378 SQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRF 429
Cdd:cd18059 148 CKLLEGLKMMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQEF 199
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
222-467 |
8.96e-23 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 97.78 E-value: 8.96e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrctTGLVDPKANGcIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd18065 16 LRDYQVRGLNWM----ISLYENGVNG-ILADEMGLGKTLQTIALLGYLKHYRNIPGPH-----MVLVPKSTLHNWMNEFK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFAIDGKASKEELTQQLR--QWSiasgravvrpVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQ 379
Cdd:cd18065 86 RWVPSLRAVCLIGDKDARAAFIRDVMMpgEWD----------VCVTSYEMVIKEKSVFKKFNWRYLVIDEAHRIKNEKSK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 380 TFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFelpilrgrdangtDKDRKLGDERLSELLTL 459
Cdd:cd18065 156 LSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSADDFDSWF-------------DTKNCLGDQKLVERLHA 222
|
....*....
gi 1832872348 460 VNK-FIIRR 467
Cdd:cd18065 223 VLKpFLLRR 231
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
222-479 |
1.03e-22 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 98.20 E-value: 1.03e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrctTGLVDPKANGcIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd18064 16 LRDYQVRGLNWL----ISLYENGING-ILADEMGLGKTLQTISLLGYMKHYRNIPGPH-----MVLVPKSTLHNWMAEFK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLgkDAITPFAIDGKaskeeltqqlRQWSIASGRAVVRP----VLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDE 377
Cdd:cd18064 86 RWV--PTLRAVCLIGD----------KDQRAAFVRDVLLPgewdVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 378 SQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFelpilrgrdangtDKDRKLGDERLSELL 457
Cdd:cd18064 154 SKLSEIVREFKTTNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDSWF-------------DTNNCLGDQKLVERL 220
|
250 260
....*....|....*....|...
gi 1832872348 458 TLVNK-FIIRRTNDILSKYLPVK 479
Cdd:cd18064 221 HMVLRpFLLRRIKADVEKSLPPK 243
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
222-429 |
1.16e-22 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 97.42 E-value: 1.16e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFL----YrcttglvdpKANGCIMADEMGLGKTLQCIALMWTLIKQSPEAgkstiqKCVIACPSSLVRNWA 297
Cdd:cd18058 1 LREYQLEGMNWLlfnwY---------NRKNCILADEMGLGKTIQSITFLSEIFLMGIRG------PFLIIAPLSTITNWE 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 298 NELVKWLGKDAITpfaIDGKASKEELTQQLR------QWSIASGRAVVRpVLIVSYETLRLNVEELKNTPIGLLLCDEGH 371
Cdd:cd18058 66 REFRTWTEMNAIV---YHGSQISRQMIQQYEmyyrdeQGNPLSGIFKFQ-VVITTFEMILADCPELKKINWSCVIIDEAH 141
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 1832872348 372 RLKNDESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRF 429
Cdd:cd18058 142 RLKNRNCKLLEGLKLMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTFLEEF 199
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
222-467 |
1.29e-22 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 97.83 E-value: 1.29e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrctTGLVDPKANGcIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd18063 24 LKHYQLQGLEWM----VSLYNNNLNG-ILADEMGLGKTIQTIALITYLMEHKRLNGPY-----LIIVPLSTLSNWTYEFD 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWlgKDAITPFAIDGK-ASKEELTQQLRqwsiaSGRAvvrPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQT 380
Cdd:cd18063 94 KW--APSVVKISYKGTpAMRRSLVPQLR-----SGKF---NVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 381 FTALNNLNVQ-KRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPI-LRGRDANGTDKDRKLGDERLSELLt 458
Cdd:cd18063 164 TQVLNTHYVApRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFaMTGERVDLNEEETILIIRRLHKVL- 242
|
....*....
gi 1832872348 459 lvNKFIIRR 467
Cdd:cd18063 243 --RPFLLRR 249
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
221-467 |
2.67e-22 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 97.04 E-value: 2.67e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 221 VLRPHQVEGVRFLyrctTGLVDPKANGcIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANEL 300
Cdd:cd18062 23 VLKQYQIKGLEWL----VSLYNNNLNG-ILADEMGLGKTIQTIALITYLMEHKRINGPF-----LIIVPLSTLSNWVYEF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 301 VKWlgKDAITPFAIDGK-ASKEELTQQLRqwsiaSGRAvvrPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQ 379
Cdd:cd18062 93 DKW--APSVVKVSYKGSpAARRAFVPQLR-----SGKF---NVLLTTYEYIIKDKQILAKIRWKYMIVDEGHRMKNHHCK 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 380 TFTALNNLNVQ-KRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFELPI-LRGRDANGTDKDRKLGDERLSELL 457
Cdd:cd18062 163 LTQVLNTHYVApRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFaMTGEKVDLNEEETILIIRRLHKVL 242
|
250
....*....|
gi 1832872348 458 tlvNKFIIRR 467
Cdd:cd18062 243 ---RPFLLRR 249
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
222-429 |
4.41e-21 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 92.76 E-value: 4.41e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTglvdpKANGCIMADEMGLGKTLQCIALMWTLIKQSPEAgkstiqKCVIACPSSLVRNWANELV 301
Cdd:cd18061 1 LREYQLEGLNWLLFNWY-----NRRNCILADEMGLGKTIQSITFLYEILLTGIRG------PFLIIAPLSTIANWEREFR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITpfaIDGKASKEELTQQLRQWSIASGRAVVR-----PVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKND 376
Cdd:cd18061 70 TWTDLNVVV---YHGSLISRQMIQQYEMYFRDSQGRIIRgayrfQAIITTFEMILGGCPELNAIDWRCVIIDEAHRLKNK 146
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 1832872348 377 ESQTFTALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRF 429
Cdd:cd18061 147 NCKLLEGLKLMNLEHKVLLTGTPLQNTVEELFSLLHFLEPLRFPSESTFMQEF 199
|
|
| DEXHc_TTF2 |
cd18072 |
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called ... |
244-415 |
1.04e-20 |
|
DEAH-box helicase domain of TTF2; Transcription termination factor 2 (TTF2 also called Forkhead-box E1/FOXE1 ) is a transcription termination factor that couples ATP hydrolysis with the removal of RNA polymerase II from the DNA template. Single nucleotide polymorphism (SNP) within the 5'-UTR of TTF2 is associated with thyroid cancer risk.TTF2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350830 [Multi-domain] Cd Length: 241 Bit Score: 92.16 E-value: 1.04e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 244 KANGCIMADEMGLGKTLQCIAL-----------------MWTLIKQSPEAGKSTIQKCVIACPSSLVRNWANELVKWLGK 306
Cdd:cd18072 19 KPRGGILADDMGLGKTLTMIALilaqkntqnrkeeekekALTEWESKKDSTLVPSAGTLVVCPASLVHQWKNEVESRVAS 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 307 DAITPFAIDGkASKEELTQQLRQWSIasgraVVRPVLIVSYEtLRLNVEELKNTPIGL-----LLCDEGHRLKNDESQTF 381
Cdd:cd18072 99 NKLRVCLYHG-PNRERIGEVLRDYDI-----VITTYSLVAKE-IPTYKEESRSSPLFRiawarIILDEAHNIKNPKVQAS 171
|
170 180 190
....*....|....*....|....*....|....
gi 1832872348 382 TALNNLNVQKRVILSGTPIQNDLSEYFALLNFAN 415
Cdd:cd18072 172 IAVCKLRAHARWALTGTPIQNNLLDMYSLLKFLR 205
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
599-683 |
1.43e-20 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 86.50 E-value: 1.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 599 DVFDKLCRSRGYGCLRLDGTMNVNKRQKLVDKFNDpegGEFVFLLSSKAGGCGLNLIGANRLVLFDPDWNPAADQQALAR 678
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNN---GKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGR 77
|
....*
gi 1832872348 679 VWRDG 683
Cdd:smart00490 78 AGRAG 82
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
222-448 |
1.08e-19 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 88.95 E-value: 1.08e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTglvdpKANGCIMADEMGLGKTLQCIALMWTLIKQSPEAGKStiqkcVIACPSSLVRNWANELV 301
Cdd:cd18053 21 LRDYQLNGLNWLAHSWC-----KGNSCILADEMGLGKTIQTISFLNYLFHEHQLYGPF-----LLVVPLSTLTSWQREIQ 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 302 KWLGKDAITPFAIDGKASKEELTQQlrqWSIASGRAVVRPVLIVSYETLRLNVEELKNTPIGLLLCDEGHRLKNDESQTF 381
Cdd:cd18053 91 TWAPQMNAVVYLGDINSRNMIRTHE---WMHPQTKRLKFNILLTTYEILLKDKSFLGGLNWAFIGVDEAHRLKNDDSLLY 167
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1832872348 382 TALNNLNVQKRVILSGTPIQNDLSEYFALLNFANPNYLGTKNEFRKRFElpilRGRDANGTDKDRKL 448
Cdd:cd18053 168 KTLIDFKSNHRLLITGTPLQNSLKELWSLLHFIMPEKFSSWEDFEEEHG----KGREYGYASLHKEL 230
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
247-467 |
4.96e-18 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 84.06 E-value: 4.96e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 247 GCIMADEMGLGKTLQCIALMWTlikqspeagkstiQKCVIACPSSLVRNWANELVKWLGKDAITPFAIDGKASKEELTQQ 326
Cdd:cd18071 50 GGILADDMGLGKTLTTISLILA-------------NFTLIVCPLSVLSNWETQFEEHVKPGQLKVYTYHGGERNRDPKLL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 327 LRQwsiasgravvrPVLIVSYETLRLNVEELKNTPIGLL-----LCDEGHRLKNDESQTFTALNNLNVQKRVILSGTPIQ 401
Cdd:cd18071 117 SKY-----------DIVLTTYNTLASDFGAKGDSPLHTInwlrvVLDEGHQIRNPNAQQTKAVLNLSSERRWVLTGTPIQ 185
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1832872348 402 NDLSEYFALLNFANPNYLGTKNEFRKRFELPILRGRDANgtdkdrklgderLSELLTLVNKFIIRR 467
Cdd:cd18071 186 NSPKDLGSLLSFLHLKPFSNPEYWRRLIQRPLTMGDPTG------------LKRLQVLMKQITLRR 239
|
|
| DpdE |
NF041062 |
protein DpdE; |
222-681 |
1.76e-10 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 64.99 E-value: 1.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRflyrctTGLVDPkangcIM----ADEMGLGKTLQCIALMWTLIKQSPEAgkstiqKCVIACPSSLVRNWA 297
Cdd:NF041062 154 LEPHQVAVVR------RVLQDP-----VQryllADEVGLGKTIEAGLVIRQHLLDNPDA------RVLVLVPDALVRQWR 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 298 NELvkwlgkdaITPFAIDgkaskEELTQQLRqwsiasgravvrpvlIVSYETLRLnVEELKNTPiGLLLCDEGHRL---- 373
Cdd:NF041062 217 REL--------RDKFFLD-----DFPGARVR---------------VLSHEEPER-WEPLLDAP-DLLVVDEAHQLarla 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 374 ---KNDESQTFTALNNL-NVQKRVI-LSGTPIQNDLSEYFALLNFANP-NY-LGTKNEFRKRFEL-----PILRGRDANG 441
Cdd:NF041062 267 wsgDPPERARYRELAALaHAAPRLLlLSATPVLGNEETFLALLHLLDPdLYpLDDLEAFRERLEEreelgRLVLGLDPDN 346
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 442 TD----------KDRKLGDERLSEL----LTLVNKFIIRRTNDI------LSKYLpvkyehvvfcnlapfqKDLYNLFiq 501
Cdd:NF041062 347 PNfllrqaldelRALFPEDEELQELaeelLPLLDEFDDEEPEERaravsaLRAHI----------------SETYRLH-- 408
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 502 speiRQLLRGKGSQPLKAI------NILKKLCNHPDLLDLPSDL------------PGSESCF----------------- 546
Cdd:NF041062 409 ----RRMIRNRRSSVLGADylvpgrAGPRVLVWESPAREAADEAledwreeaalldAESDPAAraayaralawlvarlgg 484
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 547 PDDFVPKdARGRDRDVK--SWYSGKMMVLDRMLARIRQDTND-------------------KIVLISNYTQTLD-VFDKL 604
Cdd:NF041062 485 PDDLAAL-LRWRLRGDAasADLAGERELLEALIAALEDEAKDadllaaladwllpllrgsgKAVVFCGDGSLADhLAAAL 563
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1832872348 605 CRSRGYGCLRLDGTMNVNKRQKLVDKFNDPEGGeFVfLLSSKAGGCGLNLIGANRLVLFDPDWNPAADQQALARVWR 681
Cdd:NF041062 564 ARLGAGSVERHLSGQGADQAERAVRAFRQDPSA-RV-LVCDRSGEEGLNLQGADRLVHLDLPWSPNRLEQRIGRLDR 638
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
222-409 |
9.12e-10 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 59.29 E-value: 9.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrcttgLVDPKAngCIMADeMGLGKTLQCIALMWTLIKQSPeagkstIQKCVIACPSSLVRN-WANEL 300
Cdd:cd18013 1 PHPYQKVAINFI------IEHPYC--GLFLD-MGLGKTVTTLTALSDLQLDDF------TRRVLVIAPLRVARStWPDEV 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 301 VKWLGKDAITPFAIDGKASKeeltqqlRQWSIASGRAvvrpVLIVSYETLRLNVEELKNT-PIGLLLCDEGHRLKNDESQ 379
Cdd:cd18013 66 EKWNHLRNLTVSVAVGTERQ-------RSKAANTPAD----LYVINRENLKWLVNKSGDPwPFDMVVIDELSSFKSPRSK 134
|
170 180 190
....*....|....*....|....*....|..
gi 1832872348 380 TFTALNNLNVQ-KRVI-LSGTPIQNDLSEYFA 409
Cdd:cd18013 135 RFKALRKVRPViKRLIgLTGTPSPNGLMDLWA 166
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
222-413 |
2.21e-09 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 58.89 E-value: 2.21e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLyrcttglvdpKANGCIMADEMGLGKTLQCIALMWT------------------------LIKQSPEAG 277
Cdd:cd18070 1 LLPYQRRAVNWM----------LVPGGILADEMGLGKTVEVLALILLhprpdndldaadddsdemvccpdcLVAETPVSS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 278 KSTIqkcvIACPSSLVRNWANEL-------VKWLGKDAITpfaiDGKASKEELTQQLRQWSIasgravvrpvLIVSYETL 350
Cdd:cd18070 71 KATL----IVCPSAILAQWLDEInrhvpssLKVLTYQGVK----KDGALASPAPEILAEYDI----------VVTTYDVL 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 351 RLNVEELK-----------------NTPigLLLCdEGHRLKNDESQ-----TFTALN---NLNVQKRVILSGTPIQNDLS 405
Cdd:cd18070 133 RTELHYAEanrsnrrrrrqkryeapPSP--LVLV-EWWRVCLDEAQmvessTSKAAEmarRLPRVNRWCVSGTPIQRGLD 209
|
....*...
gi 1832872348 406 EYFALLNF 413
Cdd:cd18070 210 DLFGLLSF 217
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
222-740 |
3.86e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 60.04 E-value: 3.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 222 LRPHQVEGVRFLYRCTTGlvDPKANGCIMAdeMGLGKTLqcIALMwtLIKQSpeagkSTIQKCVIACPS-SLVRNWANEL 300
Cdd:COG1061 81 LRPYQQEALEALLAALER--GGGRGLVVAP--TGTGKTV--LALA--LAAEL-----LRGKRVLVLVPRrELLEQWAEEL 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 301 VKWLGKdaitPFAIDGKASKEeltqqlrqwsiasgravvRPVLIVSYETL--RLNVEELKNTpIGLLLCDEGHRLkndES 378
Cdd:COG1061 148 RRFLGD----PLAGGGKKDSD------------------APITVATYQSLarRAHLDELGDR-FGLVIIDEAHHA---GA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 379 QTFTA-LNNLNVQKRVILSGTPIQND-LSEYFALLnfanpnylgtkneFRKRFELPIlrgRDAngtdkdrklgderlsel 456
Cdd:COG1061 202 PSYRRiLEAFPAAYRLGLTATPFRSDgREILLFLF-------------DGIVYEYSL---KEA----------------- 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 457 ltlvnkfiirrtndILSKYL-PVKYeHVVFCNLAPFQKDlYNLFIQspEIRQLLrgkgsqplkainilkklcnhpdlldl 535
Cdd:COG1061 249 --------------IEDGYLaPPEY-YGIRVDLTDERAE-YDALSE--RLREAL-------------------------- 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 536 psdlpgsescfpddfVPKDARgrdrdvkswysgKMMVLDRMLARIRQDtnDKIVLISNYTQTLDVFDKLCRSRGYGCLRL 615
Cdd:COG1061 285 ---------------AADAER------------KDKILRELLREHPDD--RKTLVFCSSVDHAEALAELLNEAGIRAAVV 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 616 DGTMNVNKRQKLVDKFNDpegGEFVFLLSSKAGGCGLNLIGANRLVLFDPDWNPAADQQALARVWRDGQ-KKDCFVYRFI 694
Cdd:COG1061 336 TGDTPKKEREEILEAFRD---GELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPgKEDALVYDFV 412
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 1832872348 695 ATGT-IEEKIFQRQSHKSALSSCVVDSAEDVERHFSIDSLRELFQYQ 740
Cdd:COG1061 413 GNDVpVLEELAKDLRDLAGYRVEFLDEEESEELALLIAVKPALEVKG 459
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
220-400 |
2.73e-07 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 51.13 E-value: 2.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 220 KVLRPHQVEGVRflyRCTTGLVDPKANGCI-MAdeMGLGKTLQCIALMWTLIKqspeagKSTIQKCVIACPS-SLVRNWA 297
Cdd:pfam04851 2 LELRPYQIEAIE---NLLESIKNGQKRGLIvMA--TGSGKTLTAAKLIARLFK------KGPIKKVLFLVPRkDLLEQAL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 298 NELVKWLGKDAITPFAIDGKASKEELTQqlrqwsiasgravvRPVLIVSYETL----RLNVEELKNTPIGLLLCDEGHRL 373
Cdd:pfam04851 71 EEFKKFLPNYVEIGEIISGDKKDESVDD--------------NKIVVTTIQSLykalELASLELLPDFFDVIIIDEAHRS 136
|
170 180
....*....|....*....|....*..
gi 1832872348 374 kNDESQTfTALNNLNVQKRVILSGTPI 400
Cdd:pfam04851 137 -GASSYR-NILEYFKPAFLLGLTATPE 161
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
245-398 |
7.55e-05 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 43.55 E-value: 7.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 245 ANGCIMADEMGLGKTLqcIALMWTLikqspEAGKSTIQKCVIACP-SSLVRNWANELVKWLGKDaITPFAIDGKASKEEL 323
Cdd:cd00046 1 GENVLITAPTGSGKTL--AALLAAL-----LLLLKKGKKVLVLVPtKALALQTAERLRELFGPG-IRVAVLVGGSSAEER 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 324 TqqlrqwSIASGRAvvrPVLIVSYETLRLNVEELKN---TPIGLLLCDEGHRLKNDE------SQTFTALNNLNVQkRVI 394
Cdd:cd00046 73 E------KNKLGDA---DIIIATPDMLLNLLLREDRlflKDLKLIIVDEAHALLIDSrgalilDLAVRKAGLKNAQ-VIL 142
|
....
gi 1832872348 395 LSGT 398
Cdd:cd00046 143 LSAT 146
|
|
| DEXHc_XPB |
cd18029 |
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription ... |
214-373 |
6.20e-04 |
|
DEXH-box helicase domain of TFIIH XPB subunit and similar proteins; TFIIH basal transcription factor complex helicase XPB subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350787 [Multi-domain] Cd Length: 169 Bit Score: 41.52 E-value: 6.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 214 IDPRLAKVLRPHQVEGVRFLY---RCTTGL-VDPkangCimademGLGKTLQCIALMwtlikqspeagkSTIQK-CVIAC 288
Cdd:cd18029 1 IDLKPSTQLRPYQEKALSKMFgngRARSGViVLP----C------GAGKTLVGITAA------------CTIKKsTLVLC 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 289 PSSL-VRNWANELVKW--LGKDAITPFAIDGKAskeeltqqlrqwsiasgRAVVRPVLIVSYETLR----------LNVE 355
Cdd:cd18029 59 TSAVsVEQWRRQFLDWttIDDEQIGRFTSDKKE-----------------IFPEAGVTVSTYSMLAntrkrspeseKFME 121
|
170
....*....|....*...
gi 1832872348 356 ELKNTPIGLLLCDEGHRL 373
Cdd:cd18029 122 FITEREWGLIILDEVHVV 139
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
569-710 |
1.18e-03 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 42.41 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1832872348 569 KMMVLDRMLARIRQ-DTNDKIVLISNYTQTLDVFDKLCRSRGYGCLRL--------DGTMNVNKRQKLVDKFNDpegGEF 639
Cdd:COG1111 336 KLSKLREILKEQLGtNPDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFvgqaskegDKGLTQKEQIEILERFRA---GEF 412
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1832872348 640 VFLLSSKAGGCGLNLIGANRLVLFDPDWNPAADQQALARVWRDGQKKdcfVYRFIATGTIEEKIFQRQSHK 710
Cdd:COG1111 413 NVLVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRKREGR---VVVLIAKGTRDEAYYWSSRRK 480
|
|
| |
