|
Name |
Accession |
Description |
Interval |
E-value |
| Sec16_C |
pfam12931 |
Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal ... |
1012-1316 |
4.59e-133 |
|
Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal region is the part that binds to Sec23, a COPII vesicle coat protein. This association is part of the transport vesicle coat structure.
Pssm-ID: 432884 Cd Length: 279 Bit Score: 415.42 E-value: 4.59e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1012 IKKDLLVGDREKAVWQAVDSRLWGHAMIMSSALDKTLWKQVVQEFVKREVRSAG-ENTESLAALYAVLSGNIEESVDELV 1090
Cdd:pfam12931 1 IRALLLTGDREKALWLALDKKLWAHALLIASTLGKEKWKEVVQEFVRSEFKGSNnKSGESLAALYQVFAGNSEEAVDELV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1091 PQSArlglqmiskggqgstrNSLDGLDRWRETLGLVLNNRTTDDHRALLSMGQLLASYNRTEASHICYLFArafsqngvf 1170
Cdd:pfam12931 81 PPSK----------------NALWALDNWRETLALVLSNRSPGDVEALLALGDLLAQYGRTEAAHICFLLA--------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1171 gGFDDSQTnvVLLGTDHRIYPTTFFRDEDAIALTEVYEFATCTLAGNQAAA-LPYLQPFKLHHAYALAEQGLRSDAQQYC 1249
Cdd:pfam12931 136 -GLPLSQT--VLLGADHVRFPSTFGNDLESILLTEIYEYALSLSPPQPPFVgLPHLLPYKLQHAAVLAEYGLVSEAQKYC 212
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1868467581 1250 ETIGTTIKSNTKPSPYFHQRLFAEIDELANRLRQAPNDGSSSWMSKPSMEKVSGSMWAKFSSFVAGD 1316
Cdd:pfam12931 213 DAITASLKSLTKKSPYYHPTLLAQLEDLSNRLSQSPQGKSSSWISKPSLDKVWGQLDKSFNKFIAGD 279
|
|
| ACE1-Sec16-like |
cd09233 |
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ... |
893-1285 |
3.32e-100 |
|
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.
Pssm-ID: 187750 [Multi-domain] Cd Length: 314 Bit Score: 324.98 E-value: 3.32e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 893 YPGPL-KTKSKKKDVVAWLSSRIAALENEGVPLslqsepdgfkRHEEKVVLWKLIRVLVENDGSLDKSADIQKSIQNIVs 971
Cdd:cd09233 1 FPGPLiKGKTKKKDVLKWLEEKIAELEENEGYL----------DLEDKLLLWKLLKLLVRQNGKLVGTDIAEQKALNRF- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 972 pgLELdssnisfdagagsgiyqssstsvqaeavdsdllqsikkdLLVGDREKAVWQAVDSRLWGHAMIMSSALDKTLWKQ 1051
Cdd:cd09233 70 --RNL---------------------------------------LLTGNRKEALELALDNGLWAHALLLASSLGKETWAE 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1052 VVQEFVKREvrsaGENTESLAALYAVLSGNIEESVDELVPQSARlglqmiskggqgstrnSLDGLDRWRETLGLVLNNRT 1131
Cdd:cd09233 109 VVSRFARSE----SKLNDPLQTLYQLFSGNSPEAITELADNPAE----------------AEWALGNWREHLAIILSNRT 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1132 TD-DHRALLSMGQLLASYNRTEASHICYLFARAFsqngvFGGFDDSQTNVVLLGTDHRIYPTtFFRDEDAIALTEVYEFA 1210
Cdd:cd09233 169 SNlDLEALVELGDLLAQRGLVEAAHICYLLAGVP-----LGPYPSSPSSCLLGGAVHNKSPR-TFATPEAIQLTEIYEYA 242
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1868467581 1211 TCTlaGNQAAALPYLQPFKLHHAYALAEQGLRSDAQQYCETIGTTIKSNTKPsPYFHQRLFAEIDELANRLRQAP 1285
Cdd:cd09233 243 LSL--GNPQFGLPHLQPYKLIHAARLAELGLVSEALKYCEAIASSLKSLTKS-PYYDPNLLAQLQDLSERLSGTS 314
|
|
| Sec16 |
pfam12932 |
Vesicle coat trafficking protein Sec16 mid-region; Sec16 is a multi-domain vesicle coat ... |
837-954 |
2.37e-57 |
|
Vesicle coat trafficking protein Sec16 mid-region; Sec16 is a multi-domain vesicle coat protein. This central region is the functional part of the molecules and thus is vital for the family's role in mediating the movement of protein-cargo between the organelles of the secretory pathway.
Pssm-ID: 432885 Cd Length: 119 Bit Score: 193.97 E-value: 2.37e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 837 APIFKFGFGGVVSSCFPQHIPRYSAGQMTPMIKPAPGEPRIRQFKDIVPFDGDIVRYPGPL-KTKSKKKDVVAWLSSRIA 915
Cdd:pfam12932 1 HPIFSFGFGGKLVTMFPKRVPRYSTGQDVPMIKRSPGEVKIRNLKDVVPLSEDLAKFPGPLvKGKSKKKEVLKWLSERIE 80
|
90 100 110
....*....|....*....|....*....|....*....
gi 1868467581 916 ALENEGVPLSLQSEPDGFKRHEEKVVLWKLIRVLVENDG 954
Cdd:pfam12932 81 ELEQSLPYSDGSLESDEKKRAEEKLLLWKLLKILVEHDG 119
|
|
| Sec16_N |
pfam12935 |
Vesicle coat trafficking protein Sec16 N-terminus; Sec16 is a multi-domain vesicle coat ... |
181-376 |
8.64e-18 |
|
Vesicle coat trafficking protein Sec16 N-terminus; Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. Over-expression of truncated mutants of only the N-terminus are lethal, and this portion does not appear to be essential for function so may act as a stabilising region.
Pssm-ID: 315590 [Multi-domain] Cd Length: 236 Bit Score: 84.43 E-value: 8.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 181 IDAGDDESGFFDQLKTQTKPIYdVPPEAESRFEEGVPLVPESDldsqsEPTAEPATKTDQHLENLFEADDEGEDGDDFFK 260
Cdd:pfam12935 8 SDDEDGEDDFFNQLKTQTKPIY-EPPEAESRFEEGVPLLDNGD-----DTPVENRSKQESQIDSVFAGDEEDDEADFFSS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 261 STGSETVaNHEKP--TITRKSTHEVISTLSSGAiDSPI-EESPADAKFGDTV---------------------------- 309
Cdd:pfam12935 82 NQESESK-KEGEPndHLTRKSTSQVLDSLKDPP-DSPEsDDSPAAEDFDEILaaaatekqqekspseedlaarwqaelsd 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1868467581 310 ----INEEEEDLAARWEAELDDD----DELLLAEDTTTETQEAPASVQSSAAPVLEQRPQT--APYQAAVPMNPYAP 376
Cdd:pfam12935 160 evpePMPMEDDLAERWQAFLDDDddllLDDETLDANSAPEEEPNGPTNDSTANSLSSPFGTpqSRYRPKPPPNPYTP 236
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
343-830 |
8.68e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 77.67 E-value: 8.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 343 EAPASVQSSAAPVLEQRPQTAPYQ-AAVPMNPYAPHQPSSSellqgiPNPYASTASLPATPFATPFATPF---APPQAQT 418
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRGDPRGPAPpSPLPPDTHAPDPPPPS------PSPAANEPDPHPPPTVPPPERPRddpAPGRVSR 2663
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 419 QSQGKAHSFAAQSREgyqspydlpdTLSRPRRPALR-KVAPPTNGVPNPVPPRSSSIPAPAPPppamasslPDLDQRPPP 497
Cdd:PHA03247 2664 PRRARRLGRAAQASS----------PPQRPRRRAARpTVGSLTSLADPPPPPPTPEPAPHALV--------SATPLPPGP 2725
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 498 SNEGHASKSFFEELPAPPPRARPGSRGGRYTPQPAPVLNAPAQSMAPPPVPPVPTVPSAEPVADNVYQAQLQAPDRMDPy 577
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDP- 2804
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 578 anlSVPSVPVGPGTGPRYSPKPPGGAIAGKPSVSPRYSPAPP-PSQASLPgRPRYVSQPANLPFQPRTSSPLAhheKTAY 656
Cdd:PHA03247 2805 ---ADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPgPPPPSLP-LGGSVAPGGDVRRRPPSRSPAA---KPAA 2877
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 657 EGHPH----ERPYTSPGPTSHPNPVLQPGSQQLPSVPTQLAHSAPYSMPDSNTSQPHSPPK-----NPFAHVASVSEPS- 726
Cdd:PHA03247 2878 PARPPvrrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRpqpplAPTTDPAGAGEPSg 2957
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 727 QRPSTETPYLPVGGAYQPNISSPPNdiqfAPPRRSQTQS--PGKQSSGPILTQTA------IEAYPRPASVHAPSSPTKT 798
Cdd:PHA03247 2958 AVPQPWLGALVPGRVAVPRFRVPQP----APSREAPASStpPLTGHSLSRVSSWAsslalhEETDPPPVSLKQTLWPPDD 3033
|
490 500 510
....*....|....*....|....*....|..
gi 1868467581 799 INPYTVTQVVPSSRQNLDLPFVEPSDGQELDP 830
Cdd:PHA03247 3034 TEDSDADSLFDSDSERSDLEALDPLPPEPHDP 3065
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
496-823 |
1.20e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 50.54 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 496 PPSNEGHASKSFFEELPAPPPRARPGSRGGRYTPQPAPVLNAPAQSMAPPPVPPVPTVPSAEPVADNVYQAQLQAPDR-- 573
Cdd:pfam03154 151 PQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtl 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 574 MDPYANLSVPSVPVGPGTGPRYSPKPPGGAIAGKPSVSPRYSPAPPPSQASLPGRPRYVSQPanLPFQPRTSSPLAHHEK 653
Cdd:pfam03154 231 IQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHP--VPPQPFPLTPQSSQSQ 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 654 ------TAYEGHPHERPYTsPGPTSHPNPVLQPGSQQLPSVPTQLAHSAP--------YSMPDSNTSQPHSPPKNPFAHV 719
Cdd:pfam03154 309 vppgpsPAAPGQSQQRIHT-PPSQSQLQSQQPPREQPLPPAPLSMPHIKPppttpipqLPNPQSHKHPPHLSGPSPFQMN 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 720 ASVSEPS-----------QRPSTETPYLPVGGAYQPnISSPPNDiqfaPPRRSQTQS---PGKQSSGPILTQTAIEAYPR 785
Cdd:pfam03154 388 SNLPPPPalkplsslsthHPPSAHPPPLQLMPQSQQ-LPPPPAQ----PPVLTQSQSlppPAASHPPTSGLHQVPSQSPF 462
|
330 340 350
....*....|....*....|....*....|....*...
gi 1868467581 786 PASVHAPSSPTKTINPYTVTQVVPSSRQNLDLPFVEPS 823
Cdd:pfam03154 463 PQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASV 500
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
1279-1568 |
5.91e-04 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 45.07 E-value: 5.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1279 NRLRQAPNDgssswmsKPSMEKVSGSMWAKFSSFVAGDESDAA----SNASAMDADVGPFAKItgtptvsrSPSVSDLYG 1354
Cdd:PTZ00395 316 DLVRGAPND-------KNSFDRGNEKTYQIYGGFHDGSPNAASagapFNGLGNQADGGHINQV--------HPDARGAWA 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1355 SypvpqGASNNASSRYAPGSQYAPGSSPEQNRGRSSMDSQRSPSlggnfpqrrgSQEPATPVESSSHIQGQSSFYGSPSS 1434
Cdd:PTZ00395 381 G-----GPHSNASYNCAAYSNAAQSNAAQSNAGFSNAGYSNPGN----------SNPGYNNAPNSNTPYNNPPNSNTPYS 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1435 YPYHSTPPQSSyMPLAPVDENPPSQPQQPFPTAAQQ-SALTSGLQAASVTfgQPIEEL--KNAAAEVPHYGGY-----EP 1506
Cdd:PTZ00395 446 NPPNSNPPYSN-LPYSNTPYSNAPLSNAPPSSAKDHhSAYHAAYQHRAAN--QPAANLptANQPAANNFHGAAgnsvgNP 522
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1868467581 1507 PAASSYEPPSYQPDLSVTADIPEAEAEEENKPKKKSYFDDEDDDNLASRASSIKNSEKAKHD 1568
Cdd:PTZ00395 523 FASRPFGSAPYGGNAATTADPNGIAKREDHPEGGTNRQKYEQSDEESVESSSSENSSENENE 584
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
567-691 |
1.05e-03 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 43.64 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 567 QLQAPDRMDPYANlsvpsvPVGPGTG-PRYSPKPPGGAIAGKPSVSPRYSPAPPPSQASLPGRPRYVSQPA-----NLPF 640
Cdd:TIGR01628 377 QLQPRMRQLPMGS------PMGGAMGqPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNGLAPMNavrapSRNA 450
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1868467581 641 QPRTS--SPLAHHEKTAYEGHPHERPYTSPGPTSHPNPVLQPGSQQLPSVPTQ 691
Cdd:TIGR01628 451 QNAAQkpPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQ 503
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Sec16_C |
pfam12931 |
Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal ... |
1012-1316 |
4.59e-133 |
|
Sec23-binding domain of Sec16; Sec16 is a multi-domain vesicle coat protein. The C-terminal region is the part that binds to Sec23, a COPII vesicle coat protein. This association is part of the transport vesicle coat structure.
Pssm-ID: 432884 Cd Length: 279 Bit Score: 415.42 E-value: 4.59e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1012 IKKDLLVGDREKAVWQAVDSRLWGHAMIMSSALDKTLWKQVVQEFVKREVRSAG-ENTESLAALYAVLSGNIEESVDELV 1090
Cdd:pfam12931 1 IRALLLTGDREKALWLALDKKLWAHALLIASTLGKEKWKEVVQEFVRSEFKGSNnKSGESLAALYQVFAGNSEEAVDELV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1091 PQSArlglqmiskggqgstrNSLDGLDRWRETLGLVLNNRTTDDHRALLSMGQLLASYNRTEASHICYLFArafsqngvf 1170
Cdd:pfam12931 81 PPSK----------------NALWALDNWRETLALVLSNRSPGDVEALLALGDLLAQYGRTEAAHICFLLA--------- 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1171 gGFDDSQTnvVLLGTDHRIYPTTFFRDEDAIALTEVYEFATCTLAGNQAAA-LPYLQPFKLHHAYALAEQGLRSDAQQYC 1249
Cdd:pfam12931 136 -GLPLSQT--VLLGADHVRFPSTFGNDLESILLTEIYEYALSLSPPQPPFVgLPHLLPYKLQHAAVLAEYGLVSEAQKYC 212
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1868467581 1250 ETIGTTIKSNTKPSPYFHQRLFAEIDELANRLRQAPNDGSSSWMSKPSMEKVSGSMWAKFSSFVAGD 1316
Cdd:pfam12931 213 DAITASLKSLTKKSPYYHPTLLAQLEDLSNRLSQSPQGKSSSWISKPSLDKVWGQLDKSFNKFIAGD 279
|
|
| ACE1-Sec16-like |
cd09233 |
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat ... |
893-1285 |
3.32e-100 |
|
Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16; COPII coat complex plays an important role in vesicular traffic of newly synthezised proteins from the endoplasmatic reticulum (ER) to the Golgi apparatus by mediating the formation of transport vesicles. COPII consists of an outer coat, made up of the scaffold proteins Sec31 and Sec13, and the cargo adaptor complex, Sec23 and Sec24, which are recruited by the small GTPase Sar1. Sec16 is involved in the early steps of the assembly process. Sec16 forms elongated heterotetramers with Sec13, Sec13-(Sec16)2-Sec13. It interacts with Sec13 by insertion of a single beta-blade to close the six-bladded beta propeller of Sec13. In the same way Sec13 interacts with Sec31 and Nup145C, a nuclear pore protein, all of these contain a structurally related ancestral coatomer element 1 (ACE1). Sec16 is believed to be a key component in maintaining the integrity of the ER exit site.
Pssm-ID: 187750 [Multi-domain] Cd Length: 314 Bit Score: 324.98 E-value: 3.32e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 893 YPGPL-KTKSKKKDVVAWLSSRIAALENEGVPLslqsepdgfkRHEEKVVLWKLIRVLVENDGSLDKSADIQKSIQNIVs 971
Cdd:cd09233 1 FPGPLiKGKTKKKDVLKWLEEKIAELEENEGYL----------DLEDKLLLWKLLKLLVRQNGKLVGTDIAEQKALNRF- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 972 pgLELdssnisfdagagsgiyqssstsvqaeavdsdllqsikkdLLVGDREKAVWQAVDSRLWGHAMIMSSALDKTLWKQ 1051
Cdd:cd09233 70 --RNL---------------------------------------LLTGNRKEALELALDNGLWAHALLLASSLGKETWAE 108
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1052 VVQEFVKREvrsaGENTESLAALYAVLSGNIEESVDELVPQSARlglqmiskggqgstrnSLDGLDRWRETLGLVLNNRT 1131
Cdd:cd09233 109 VVSRFARSE----SKLNDPLQTLYQLFSGNSPEAITELADNPAE----------------AEWALGNWREHLAIILSNRT 168
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1132 TD-DHRALLSMGQLLASYNRTEASHICYLFARAFsqngvFGGFDDSQTNVVLLGTDHRIYPTtFFRDEDAIALTEVYEFA 1210
Cdd:cd09233 169 SNlDLEALVELGDLLAQRGLVEAAHICYLLAGVP-----LGPYPSSPSSCLLGGAVHNKSPR-TFATPEAIQLTEIYEYA 242
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1868467581 1211 TCTlaGNQAAALPYLQPFKLHHAYALAEQGLRSDAQQYCETIGTTIKSNTKPsPYFHQRLFAEIDELANRLRQAP 1285
Cdd:cd09233 243 LSL--GNPQFGLPHLQPYKLIHAARLAELGLVSEALKYCEAIASSLKSLTKS-PYYDPNLLAQLQDLSERLSGTS 314
|
|
| Sec16 |
pfam12932 |
Vesicle coat trafficking protein Sec16 mid-region; Sec16 is a multi-domain vesicle coat ... |
837-954 |
2.37e-57 |
|
Vesicle coat trafficking protein Sec16 mid-region; Sec16 is a multi-domain vesicle coat protein. This central region is the functional part of the molecules and thus is vital for the family's role in mediating the movement of protein-cargo between the organelles of the secretory pathway.
Pssm-ID: 432885 Cd Length: 119 Bit Score: 193.97 E-value: 2.37e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 837 APIFKFGFGGVVSSCFPQHIPRYSAGQMTPMIKPAPGEPRIRQFKDIVPFDGDIVRYPGPL-KTKSKKKDVVAWLSSRIA 915
Cdd:pfam12932 1 HPIFSFGFGGKLVTMFPKRVPRYSTGQDVPMIKRSPGEVKIRNLKDVVPLSEDLAKFPGPLvKGKSKKKEVLKWLSERIE 80
|
90 100 110
....*....|....*....|....*....|....*....
gi 1868467581 916 ALENEGVPLSLQSEPDGFKRHEEKVVLWKLIRVLVENDG 954
Cdd:pfam12932 81 ELEQSLPYSDGSLESDEKKRAEEKLLLWKLLKILVEHDG 119
|
|
| Sec16_N |
pfam12935 |
Vesicle coat trafficking protein Sec16 N-terminus; Sec16 is a multi-domain vesicle coat ... |
181-376 |
8.64e-18 |
|
Vesicle coat trafficking protein Sec16 N-terminus; Sec16 is a multi-domain vesicle coat protein. The overall function of Sec16 is in mediating the movement of protein-cargo between the organelles of the secretory pathway. Over-expression of truncated mutants of only the N-terminus are lethal, and this portion does not appear to be essential for function so may act as a stabilising region.
Pssm-ID: 315590 [Multi-domain] Cd Length: 236 Bit Score: 84.43 E-value: 8.64e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 181 IDAGDDESGFFDQLKTQTKPIYdVPPEAESRFEEGVPLVPESDldsqsEPTAEPATKTDQHLENLFEADDEGEDGDDFFK 260
Cdd:pfam12935 8 SDDEDGEDDFFNQLKTQTKPIY-EPPEAESRFEEGVPLLDNGD-----DTPVENRSKQESQIDSVFAGDEEDDEADFFSS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 261 STGSETVaNHEKP--TITRKSTHEVISTLSSGAiDSPI-EESPADAKFGDTV---------------------------- 309
Cdd:pfam12935 82 NQESESK-KEGEPndHLTRKSTSQVLDSLKDPP-DSPEsDDSPAAEDFDEILaaaatekqqekspseedlaarwqaelsd 159
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1868467581 310 ----INEEEEDLAARWEAELDDD----DELLLAEDTTTETQEAPASVQSSAAPVLEQRPQT--APYQAAVPMNPYAP 376
Cdd:pfam12935 160 evpePMPMEDDLAERWQAFLDDDddllLDDETLDANSAPEEEPNGPTNDSTANSLSSPFGTpqSRYRPKPPPNPYTP 236
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
343-830 |
8.68e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 77.67 E-value: 8.68e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 343 EAPASVQSSAAPVLEQRPQTAPYQ-AAVPMNPYAPHQPSSSellqgiPNPYASTASLPATPFATPFATPF---APPQAQT 418
Cdd:PHA03247 2590 DAPPQSARPRAPVDDRGDPRGPAPpSPLPPDTHAPDPPPPS------PSPAANEPDPHPPPTVPPPERPRddpAPGRVSR 2663
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 419 QSQGKAHSFAAQSREgyqspydlpdTLSRPRRPALR-KVAPPTNGVPNPVPPRSSSIPAPAPPppamasslPDLDQRPPP 497
Cdd:PHA03247 2664 PRRARRLGRAAQASS----------PPQRPRRRAARpTVGSLTSLADPPPPPPTPEPAPHALV--------SATPLPPGP 2725
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 498 SNEGHASKSFFEELPAPPPRARPGSRGGRYTPQPAPVLNAPAQSMAPPPVPPVPTVPSAEPVADNVYQAQLQAPDRMDPy 577
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDP- 2804
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 578 anlSVPSVPVGPGTGPRYSPKPPGGAIAGKPSVSPRYSPAPP-PSQASLPgRPRYVSQPANLPFQPRTSSPLAhheKTAY 656
Cdd:PHA03247 2805 ---ADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPgPPPPSLP-LGGSVAPGGDVRRRPPSRSPAA---KPAA 2877
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 657 EGHPH----ERPYTSPGPTSHPNPVLQPGSQQLPSVPTQLAHSAPYSMPDSNTSQPHSPPK-----NPFAHVASVSEPS- 726
Cdd:PHA03247 2878 PARPPvrrlARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRpqpplAPTTDPAGAGEPSg 2957
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 727 QRPSTETPYLPVGGAYQPNISSPPNdiqfAPPRRSQTQS--PGKQSSGPILTQTA------IEAYPRPASVHAPSSPTKT 798
Cdd:PHA03247 2958 AVPQPWLGALVPGRVAVPRFRVPQP----APSREAPASStpPLTGHSLSRVSSWAsslalhEETDPPPVSLKQTLWPPDD 3033
|
490 500 510
....*....|....*....|....*....|..
gi 1868467581 799 INPYTVTQVVPSSRQNLDLPFVEPSDGQELDP 830
Cdd:PHA03247 3034 TEDSDADSLFDSDSERSDLEALDPLPPEPHDP 3065
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
345-738 |
4.29e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 61.88 E-value: 4.29e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 345 PASVQSSAAPVLEQRPQTAPYQAAVPMNPYAPHQPSSSE--LLQGIPNPYASTASLPATPFATPFATPFAPPQAQTQSqg 422
Cdd:PHA03247 2708 PEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAgpATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR-- 2785
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 423 KAHSFAAQSREGYQSPYDLPD--TLSRPRRPALRKVAPPTNGVPNPV------PPRSSSIPAPAPPPPAMASSLPDLDQR 494
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADppAAVLAPAAALPPAASPAGPLPPPTsaqptaPPPPPGPPPPSLPLGGSVAPGGDVRRR 2865
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 495 PPPsneghasksffeelpAPPPRARPGSRGGRYTPQPAPVLNAPAQSMAPPPVPPVPTVPSAEPVADNVYQAQLQAPDRM 574
Cdd:PHA03247 2866 PPS---------------RSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 575 DPYANLSVPSVPVGPGTGPRYSPKPPGGAIAGKPSVSPRYSPAPPPSQASLPGRPRYVSQPanlPFQPRTSSPLAHHEKT 654
Cdd:PHA03247 2931 PPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPAS---STPPLTGHSLSRVSSW 3007
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 655 AYEGHPHERPytSPGPTSHPNpVLQPGSQQLPSVPTQLAHSAP----YSMPDSNTSQPHSPPKNPFAHVASVSEPSQRPS 730
Cdd:PHA03247 3008 ASSLALHEET--DPPPVSLKQ-TLWPPDDTEDSDADSLFDSDSersdLEALDPLPPEPHDPFAHEPDPATPEAGARESPS 3084
|
....*...
gi 1868467581 731 TETPYLPV 738
Cdd:PHA03247 3085 SQFGPPPL 3092
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
489-825 |
4.39e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 52.25 E-value: 4.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 489 PDLDQRPPPSNEGHASKS-----------------FFEELPA----------PPPRARPGSRGGRYTPQPAPVLNAPA-Q 540
Cdd:PHA03247 2504 PDPDAPPAPSRLAPAILPdepvgepvhprmltwirGLEELASddagdpppplPPAAPPAAPDRSVPPPRPAPRPSEPAvT 2583
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 541 SMAPPPVPPVPTVPSAEPVADNVYQAQLQAPDRMDPYANlsvPSVPVGPGTGPRYSPKPPGGAIAGKPSVSPRYSPAPP- 619
Cdd:PHA03247 2584 SRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTH---APDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGr 2660
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 620 ---PSQASLPGRPRYVSQPANLPFQPRTSSPLAHHEKTAyegHPHerpytSPGPTSHPNPVLQPGSQQLPSVPTQLAHSA 696
Cdd:PHA03247 2661 vsrPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLA---DPP-----PPPPTPEPAPHALVSATPLPPGPAAARQAS 2732
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 697 PysmPDSNTSQPHSPPKNPfAHVASVSEPSQRPSTETPYLPVGGAYQPnisSPPNDIQFAPPRRSQTQSPGKQSSGPILT 776
Cdd:PHA03247 2733 P---ALPAAPAPPAVPAGP-ATPGGPARPARPPTTAGPPAPAPPAAPA---AGPPRRLTRPAVASLSESRESLPSPWDPA 2805
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 1868467581 777 QTAIEAYPRPASVHAPSSPTKTINPYTVTQVVPSSRQNLDLPFVEPSDG 825
Cdd:PHA03247 2806 DPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGG 2854
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
445-801 |
7.60e-06 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 51.22 E-value: 7.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 445 LSRPRRPALRKVAPPTNGVPNPVPPRSSSIPAPAPPPPAMASSLP---DLDQRPPPSNEGHASKSFFEELpappprarpg 521
Cdd:PHA03378 577 LTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQSHIPETSAPrqwPMPLRPIPMRPLRMQPITFNVL---------- 646
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 522 srGGRYTPQPAPVLNAPAQSMAPPPVPPVPTVPSAEPVADNVYQAqlqAPDRMDPYANLSVPSVPVGPGTGPRyspKPPG 601
Cdd:PHA03378 647 --VFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGANTMLPIQW---APGTMQPPPRAPTPMRPPAAPPGRA---QRPA 718
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 602 GAIAGKPSVSPRYSPAPPPSQASLPGRPryvSQPANLPFQPRTSSPLAHHEKTAYEGHPHERPYTSPGPTSHPNPVLQPG 681
Cdd:PHA03378 719 AATGRARPPAAAPGRARPPAAAPGRARP---PAAAPGRARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPT 795
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 682 SQQLPSVPTQLAHSAPYSMPDSNTSQPHSPPKNPFAHVASVSEPSQRPSTETPYLPVGGAYQPNISSPPNDIQ---FAPP 758
Cdd:PHA03378 796 PQPPPQAGPTSMQLMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAALERQAAAGPTPSPGSGTSDKIVQapvFYPP 875
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1868467581 759 RRSQTQSPGK-QSSGPILTQTAIEA---YPRPASVHAPSSPTKTINP 801
Cdd:PHA03378 876 VLQPIQVMRQlGSVRAAAASTVTQApteYTGERRGVGPMHPTDIPPS 922
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
496-823 |
1.20e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 50.54 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 496 PPSNEGHASKSFFEELPAPPPRARPGSRGGRYTPQPAPVLNAPAQSMAPPPVPPVPTVPSAEPVADNVYQAQLQAPDR-- 573
Cdd:pfam03154 151 PQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtl 230
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 574 MDPYANLSVPSVPVGPGTGPRYSPKPPGGAIAGKPSVSPRYSPAPPPSQASLPGRPRYVSQPanLPFQPRTSSPLAHHEK 653
Cdd:pfam03154 231 IQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHP--VPPQPFPLTPQSSQSQ 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 654 ------TAYEGHPHERPYTsPGPTSHPNPVLQPGSQQLPSVPTQLAHSAP--------YSMPDSNTSQPHSPPKNPFAHV 719
Cdd:pfam03154 309 vppgpsPAAPGQSQQRIHT-PPSQSQLQSQQPPREQPLPPAPLSMPHIKPppttpipqLPNPQSHKHPPHLSGPSPFQMN 387
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 720 ASVSEPS-----------QRPSTETPYLPVGGAYQPnISSPPNDiqfaPPRRSQTQS---PGKQSSGPILTQTAIEAYPR 785
Cdd:pfam03154 388 SNLPPPPalkplsslsthHPPSAHPPPLQLMPQSQQ-LPPPPAQ----PPVLTQSQSlppPAASHPPTSGLHQVPSQSPF 462
|
330 340 350
....*....|....*....|....*....|....*...
gi 1868467581 786 PASVHAPSSPTKTINPYTVTQVVPSSRQNLDLPFVEPS 823
Cdd:pfam03154 463 PQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASV 500
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
347-774 |
1.52e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 50.15 E-value: 1.52e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 347 SVQSSAAPVLEQRPQTAPYQAAVPMNPyAPHQPSSSELLQGIPNPYASTASLPATPfatpfatPFAPPQAQTQSQGKAHS 426
Cdd:pfam03154 158 SDSSAQQQILQTQPPVLQAQSGAASPP-SPPPPGTTQAATAGPTPSAPSVPPQGSP-------ATSQPPNQTQSTAAPHT 229
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 427 FAAqsregyQSPYDLPDTLSRPRrpalrkvaPPTNGVPNPVPPRSSSIPAPAPPPPAMasslpdldQRPPPSNEGHASKS 506
Cdd:pfam03154 230 LIQ------QTPTLHPQRLPSPH--------PPLQPMTQPPPPSQVSPQPLPQPSLHG--------QMPPMPHSLQTGPS 287
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 507 FFEE-LPAPPPRARPGSRGGRYTPQPAPVLNAPAQSMAPPPVPPVptvpsaepvadnvyQAQLQAPDRMDPyanlsvpsV 585
Cdd:pfam03154 288 HMQHpVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQS--------------QLQSQQPPREQP--------L 345
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 586 PVGPGTGPRYSPkPPGGAIAGKPsvSPRYSPAPPPSQASLPgrpryVSQPANLPFQP--RTSSPLAHHektayegHPher 663
Cdd:pfam03154 346 PPAPLSMPHIKP-PPTTPIPQLP--NPQSHKHPPHLSGPSP-----FQMNSNLPPPPalKPLSSLSTH-------HP--- 407
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 664 pytspgPTSHPNPV-LQPGSQQLPSVPTQlahsapysMPDSNTSQPHSPPKNPFAHVASV-SEPSQRPSTETPYLPVGGA 741
Cdd:pfam03154 408 ------PSAHPPPLqLMPQSQQLPPPPAQ--------PPVLTQSQSLPPPAASHPPTSGLhQVPSQSPFPQHPFVPGGPP 473
|
410 420 430
....*....|....*....|....*....|...
gi 1868467581 742 YQPNISSPPNDIQFAPPRRSQTQSPGKQSSGPI 774
Cdd:pfam03154 474 PITPPSGPPTSTSSAMPGIQPPSSASVSSSGPV 506
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
565-875 |
1.80e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 49.77 E-value: 1.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 565 QAQLQAPDRMDPYANLSVPSVPVgPGTGPRYSPKPPGGAIAGKPSVSPRYSpaPPPSQASLPGRPRYVSQPANLPFQPRT 644
Cdd:pfam03154 166 ILQTQPPVLQAQSGAASPPSPPP-PGTTQAATAGPTPSAPSVPPQGSPATS--QPPNQTQSTAAPHTLIQQTPTLHPQRL 242
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 645 SSPlahheKTAYEGHPHERPYTSPGPTSHPNPVL----QPGSQQLPSVPTQLAHSAP----YSMPDSNTSQPHSPPKNPF 716
Cdd:pfam03154 243 PSP-----HPPLQPMTQPPPPSQVSPQPLPQPSLhgqmPPMPHSLQTGPSHMQHPVPpqpfPLTPQSSQSQVPPGPSPAA 317
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 717 AHVAS---------VSEPSQRPSTETPyLPVGGAYQPNISSPPNdIQFAPPRRSQTQSPGKQSSGPILTQTAIEAYPRPA 787
Cdd:pfam03154 318 PGQSQqrihtppsqSQLQSQQPPREQP-LPPAPLSMPHIKPPPT-TPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPA 395
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 788 SvhAPSSPTKTINPYTV----TQVVPSSRQNLDLPFVEPSDGQELDPLQRWRGAPIFKFGFGGVVSSCFPQH--IPRYSA 861
Cdd:pfam03154 396 L--KPLSSLSTHHPPSAhpppLQLMPQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHpfVPGGPP 473
|
330
....*....|....
gi 1868467581 862 GQMTPMIKPAPGEP 875
Cdd:pfam03154 474 PITPPSGPPTSTSS 487
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
583-782 |
2.40e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 49.21 E-value: 2.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 583 PSVPVGPGTGPRYSPKPPGGAIAGKPSVSPRYSPAPPPSQASLPGRPRYVSQPANLPFQPRTSSPLAHHEKTAYEGHPHE 662
Cdd:PRK07764 590 PAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGW 669
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 663 RPYTSPGPTSHPNPVLQPGSQQLPSVPTQlAHSAPYSMPDSNTSQPHSPPKNPFAHVASVSEPSQRPSTETPYLP----V 738
Cdd:PRK07764 670 PAKAGGAAPAAPPPAPAPAAPAAPAGAAP-AQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLPPepddP 748
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 1868467581 739 GGAYQPNISSPPNDIQFAPPRRSQTQSPGKQSSGPILTQTAIEA 782
Cdd:PRK07764 749 PDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPS 792
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
603-811 |
2.46e-05 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 49.05 E-value: 2.46e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 603 AIAGKPSVSPRYSPAPPPSQASLPGRPRYVSQP-ANLPFQPRTSSPLAHHEK----TAYEGHPHERPYTSPGPtsHPNPV 677
Cdd:PRK14086 85 AITVDPSAGEPAPPPPHARRTSEPELPRPGRRPyEGYGGPRADDRPPGLPRQdqlpTARPAYPAYQQRPEPGA--WPRAA 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 678 LQPGSQQLPSVPTQLA----------HSAPYSMPDSNTSQPHSPPKNPFAHVASVSEPSQRPSTETPYLPVGGAYQPNIS 747
Cdd:PRK14086 163 DDYGWQQQRLGFPPRApyaspasyapEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRRDRTDRPEPPPGAGHVHRGG 242
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1868467581 748 SPPNDIQFAPPRRSQTQSPGKQSSgpiltqtaieaypRPASVHAPSSPTKTINP-YTV-TQVVPSS 811
Cdd:PRK14086 243 PGPPERDDAPVVPIRPSAPGPLAA-------------QPAPAPGPGEPTARLNPkYTFdTFVIGAS 295
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
410-830 |
3.24e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.17 E-value: 3.24e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 410 PFAPPQAQTQSQGKAHSFAAQSREGYQSPYDLPD-TLSRPRRP-------ALRKVAPPTNGVPNPVPPRSSSIPAPAPPP 481
Cdd:PHA03247 2489 PFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDePVGEPVHPrmltwirGLEELASDDAGDPPPPLPPAAPPAAPDRSV 2568
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 482 PAMasslpdldqRPPPSNEGHASKSFFEELPAPPPRARPGSRGGRYTPQPAPVLNAPAQSMAPPPVPPVPTVPSA----- 556
Cdd:PHA03247 2569 PPP---------RPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAanepd 2639
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 557 ----EPVADNVYQAQLQAPDRMDPYANLSVPSVPVGPGTGPRySPKPPG--------GAIAGKPSVSPRYSPAPPPSQAS 624
Cdd:PHA03247 2640 phppPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQ-RPRRRAarptvgslTSLADPPPPPPTPEPAPHALVSA 2718
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 625 LPGRPRYVSQPANLPFQPRTSSPLAHHEKTAYEGHPHE--RPYTSPGPTShPNPVLQPGSQQLPSVPTQLAHSAPYSMPD 702
Cdd:PHA03247 2719 TPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARpaRPPTTAGPPA-PAPPAAPAAGPPRRLTRPAVASLSESRES 2797
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 703 SNTSQPHSPPKNPFAHVASVSEPSQRPSTETPYLPvggAYQPNISSPPNdiqfAPPRRSQTQSPGKQSSGPILTqtaiea 782
Cdd:PHA03247 2798 LPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT---SAQPTAPPPPP----GPPPPSLPLGGSVAPGGDVRR------ 2864
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 1868467581 783 ypRPASVHAPSSPTKTINPYTVTQVVPSSRQNLDlPFVEPSDGQELDP 830
Cdd:PHA03247 2865 --RPPSRSPAAKPAAPARPPVRRLARPAVSRSTE-SFALPPDQPERPP 2909
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
533-792 |
1.27e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 47.00 E-value: 1.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 533 PVLN-----APAQSMAPPPVPPVPTVPSAEPVadnvyqaqLQAPDRMDPYANLSVPSV---PV-GPGTG-PRYSPKP--- 599
Cdd:PRK10263 309 PLLNgapitEPVAVAAAATTATQSWAAPVEPV--------TQTPPVASVDVPPAQPTVawqPVpGPQTGePVIAPAPegy 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 600 ---PGGAIAGKPSVSPRYSPAPPPSQASLPGRPRYVSQP--ANLPFQPRTSSPLAHHEKTAYEGHPHERPytSPGPTSHP 674
Cdd:PRK10263 381 pqqSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPyyAPAPEQPAQQPYYAPAPEQPVAGNAWQAE--EQQSTFAP 458
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 675 NPVLQPGSQQLPSVPTQLAHSAPYSMPDSNTSQPH------SPPKNPFAHVASVSEPSQRPSTETP--YLPVGGAYQPNI 746
Cdd:PRK10263 459 QSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPEpvveetKPARPPLYYFEEVEEKRAREREQLAawYQPIPEPVKEPE 538
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 1868467581 747 SSPPNDIQFAPPRRSQTQSPGKQSSGPILTQTAIEAYPRPASVHAP 792
Cdd:PRK10263 539 PIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLATGAAATVAAP 584
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
529-734 |
3.61e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 45.25 E-value: 3.61e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 529 PQPAPVLNAPAQSMAPPPVPPVPTVPSAEPVADNVYQAQLQAPDRMDPyanlsvpsVPVGPGTGPRYSPKPPGGAIAGKP 608
Cdd:PRK12323 381 PVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSP--------APEALAAARQASARGPGGAPAPAP 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 609 SVSPRYSPAPPPSQASLPGRPRYVSQPANLPFQPRTSSPlAHHEKTAYEGHPHERPytSPGPTSHPNPVLQPGSQQLPSV 688
Cdd:PRK12323 453 APAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAP-ADDDPPPWEELPPEFA--SPAPAQPDAAPAGWVAESIPDP 529
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 1868467581 689 PTQLAHSAPYSMPDSNTSQPHSPPKNPFAHVASVSEPSQRPSTETP 734
Cdd:PRK12323 530 ATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPD 575
|
|
| PLN03209 |
PLN03209 |
translocon at the inner envelope of chloroplast subunit 62; Provisional |
530-796 |
3.74e-04 |
|
translocon at the inner envelope of chloroplast subunit 62; Provisional
Pssm-ID: 178748 [Multi-domain] Cd Length: 576 Bit Score: 45.30 E-value: 3.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 530 QPAPVLNAPAQSMAPPPVPPVPTVPSAEPVADNVYQAQLQAPDRMDPYA---NLSVPSVPvgpgtgprySPKPPGGAIAG 606
Cdd:PLN03209 327 RVPPKESDAADGPKPVPTKPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTayeDLKPPTSP---------IPTPPSSSPAS 397
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 607 KPSVSPRYSPAPPPSQASlPGRPRYVSQPANLPFQPRTSSPLahhekTAYEGHPHERPYTSPGPTshpnpvlqPGSQQLP 686
Cdd:PLN03209 398 SKSVDAVAKPAEPDVVPS-PGSASNVPEVEPAQVEAKKTRPL-----SPYARYEDLKPPTSPSPT--------APTGVSP 463
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 687 SVptqlahsapySMPDSNTSQPHSPPKNPFAHVASVSEPSQRPSteTPYLPVGGAYQPNISSPPNDIQFAPPRRSQTQSP 766
Cdd:PLN03209 464 SV----------SSTSSVPAVPDTAPATAATDAAAPPPANMRPL--SPYAVYDDLKPPTSPSPAAPVGKVAPSSTNEVVK 531
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 1868467581 767 GKQSSGP---ILTQTAIEAYPRPAS-------VHAPSSPT 796
Cdd:PLN03209 532 VGNSAPPtalADEQHHAQPKPRPLSpytmyedLKPPTSPT 571
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
1279-1568 |
5.91e-04 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 45.07 E-value: 5.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1279 NRLRQAPNDgssswmsKPSMEKVSGSMWAKFSSFVAGDESDAA----SNASAMDADVGPFAKItgtptvsrSPSVSDLYG 1354
Cdd:PTZ00395 316 DLVRGAPND-------KNSFDRGNEKTYQIYGGFHDGSPNAASagapFNGLGNQADGGHINQV--------HPDARGAWA 380
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1355 SypvpqGASNNASSRYAPGSQYAPGSSPEQNRGRSSMDSQRSPSlggnfpqrrgSQEPATPVESSSHIQGQSSFYGSPSS 1434
Cdd:PTZ00395 381 G-----GPHSNASYNCAAYSNAAQSNAAQSNAGFSNAGYSNPGN----------SNPGYNNAPNSNTPYNNPPNSNTPYS 445
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 1435 YPYHSTPPQSSyMPLAPVDENPPSQPQQPFPTAAQQ-SALTSGLQAASVTfgQPIEEL--KNAAAEVPHYGGY-----EP 1506
Cdd:PTZ00395 446 NPPNSNPPYSN-LPYSNTPYSNAPLSNAPPSSAKDHhSAYHAAYQHRAAN--QPAANLptANQPAANNFHGAAgnsvgNP 522
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1868467581 1507 PAASSYEPPSYQPDLSVTADIPEAEAEEENKPKKKSYFDDEDDDNLASRASSIKNSEKAKHD 1568
Cdd:PTZ00395 523 FASRPFGSAPYGGNAATTADPNGIAKREDHPEGGTNRQKYEQSDEESVESSSSENSSENENE 584
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
583-797 |
6.88e-04 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 44.68 E-value: 6.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 583 PSVPVGPGTGPR-YSPKPPGGAIAGKPSVSPRySPaPPPSQASLPGRPRYVSQPAN--------LPFQPRTSSPLahHEK 653
Cdd:PTZ00449 603 AQRPTRPKSPKLpELLDIPKSPKRPESPKSPK-RP-PPPQRPSSPERPEGPKIIKSpkppkspkPPFDPKFKEKF--YDD 678
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 654 TAYEGHPHERPYTSPGPTSHPNPVLQPGSQQLPSVPTQLAHSAPYSMPdSNTSQPHSPPKNPFAHVASVSEPSQRPSTET 733
Cdd:PTZ00449 679 YLDAAAKSKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKLP-RDEEFPFEPIGDPDAEQPDDIEFFTPPEEER 757
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1868467581 734 PYLPVGGAYQPNISSPPNDIQfAPPRRSQTQSPGKQSSGPiltQTAIEAYPRPASVHaPSSPTK 797
Cdd:PTZ00449 758 TFFHETPADTPLPDILAEEFK-EEDIHAETGEPDEAMKRP---DSPSEHEDKPPGDH-PSLPKK 816
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
567-691 |
1.05e-03 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 43.64 E-value: 1.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 567 QLQAPDRMDPYANlsvpsvPVGPGTG-PRYSPKPPGGAIAGKPSVSPRYSPAPPPSQASLPGRPRYVSQPA-----NLPF 640
Cdd:TIGR01628 377 QLQPRMRQLPMGS------PMGGAMGqPPYYGQGPQQQFNGQPLGWPRMSMMPTPMGPGGPLRPNGLAPMNavrapSRNA 450
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 1868467581 641 QPRTS--SPLAHHEKTAYEGHPHERPYTSPGPTSHPNPVLQPGSQQLPSVPTQ 691
Cdd:TIGR01628 451 QNAAQkpPMQPVMYPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVLASATPQ 503
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
587-767 |
1.15e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.82 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 587 VGPGTGPRYSPKPPGGAIAGKPSVSPRYSPAPPPSQASLPGRPRYVSQPANLPFQPRTSSPLAHHEKtayEGHPHERPYT 666
Cdd:PRK07764 588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHP---KHVAVPDASD 664
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 667 SPGPTSHPNPVLQPGSQQLPSVPTQLAHSAPYSMPDSNTSQPHSPPKNPfaHVASVSEPSQRPSTETPYLPVGGAYQPNI 746
Cdd:PRK07764 665 GGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQ--ADDPAAQPPQAAQGASAPSPAADDPVPLP 742
|
170 180
....*....|....*....|.
gi 1868467581 747 SSPPNDIQFAPPRRSQTQSPG 767
Cdd:PRK07764 743 PEPDDPPDPAGAPAQPPPPPA 763
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
344-702 |
1.25e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 43.82 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 344 APASVQSSAAPVLEQRPQTAPYQAAVPM-NPYAPHQPSSSELLQGIPNPYASTASLPATPFATPFATPFAPPQAQTQSQG 422
Cdd:PRK07764 407 AAAPAPAAAAPAAAAAPAPAAAPQPAPApAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPA 486
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 423 KAHSFAAQSREGYQSPYDLPDTLSRPRR--PALRKVAPPTNGVPNPVPPRSSSIPAPAPPPPAMASSLPDLDQR--PPPS 498
Cdd:PRK07764 487 APAPAAAPAAPAAPAAPAGADDAATLRErwPEILAAVPKRSRKTWAILLPEATVLGVRGDTLVLGFSTGGLARRfaSPGN 566
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 499 NE--------------------GHASKSFFEELPAPPPRARPGSRGGRYTPQPAPVlnAPAQSMAPPPVPPVPTVPSAEP 558
Cdd:PRK07764 567 AEvlvtalaeelggdwqveavvGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPA--APAAPAPAGAAAAPAEASAAPA 644
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 559 VADNVYQAQLQAPDRMDPYANLSVPSVPVGPGTGPRYSPKPPGGAIAGKPSVSPRYSPAPPPSQASLPGRPRYVSQPANl 638
Cdd:PRK07764 645 PGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQ- 723
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1868467581 639 PFQPRTSSPLAHHEKTAYEGHPHERPYTSPGPTSHPNPVLQPGSQQLPSVPTQLAHSAPYSMPD 702
Cdd:PRK07764 724 AAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAE 787
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
337-801 |
1.71e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 43.54 E-value: 1.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 337 TTTETQEAPASVQSSAAPVLEqrPQTAPYQAAVPMNPY-APHQPSSSELLQGIPNPYASTASLPATPFATPFATPFAPPQ 415
Cdd:PRK10263 328 TATQSWAAPVEPVTQTPPVAS--VDVPPAQPTVAWQPVpGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQ 405
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 416 AQTQSQGKAHSFAAQSREGYQSPYDLPDTLSRPRRPALRK--VAPPTNGV--PNPVPPRSSSIPAPAPPPPA----MASS 487
Cdd:PRK10263 406 PYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNawQAEEQQSTfaPQSTYQTEQTYQQPAAQEPLyqqpQPVE 485
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 488 LPDLDQRPPPSNEGHASKS---FFEELPAPPPRARPgSRGGRYTPQPAPV-----LNAPAQSMAPPPVPPVPTVPSAEPV 559
Cdd:PRK10263 486 QQPVVEPEPVVEETKPARPplyYFEEVEEKRARERE-QLAAWYQPIPEPVkepepIKSSLKAPSVAAVPPVEAAAAVSPL 564
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 560 ADNVYQAQLQApdrmDPYANLSVPSVPVGPGTGPRyspkppggaiagkPSVSPRYSPA-PPPSQASLPGRPRYVSQPANL 638
Cdd:PRK10263 565 ASGVKKATLAT----GAAATVAAPVFSLANSGGPR-------------PQVKEGIGPQlPRPKRIRVPTRRELASYGIKL 627
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 639 PFQPRTSSPLAHHEKTAY--------------------------------EGHPHERPYTSPGPTSHPNPVLQ---PGSQ 683
Cdd:PRK10263 628 PSQRAAEEKAREAQRNQYdsgdqynddeidamqqdelarqfaqtqqqrygEQYQHDVPVNAEDADAAAEAELArqfAQTQ 707
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 684 QLPSVPTQLAHSAPYSMPDSNTSQ--------PHSP-----------PKNPFAHVASVSEPSQ----RPSTETPYLPVGG 740
Cdd:PRK10263 708 QQRYSGEQPAGANPFSLDDFEFSPmkallddgPHEPlftpivepvqqPQQPVAPQQQYQQPQQpvapQPQYQQPQQPVAP 787
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1868467581 741 AYQPNISSPPNDIQFAPPRRSQTQSPGKQSSGPILTQTAIEAYPRPASVHAPSSPTKTINP 801
Cdd:PRK10263 788 QPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQDTLLHP 848
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
632-809 |
1.96e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 43.15 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 632 VSQPANLPFQPRTSSPLAHHEKTAYEgHPHERPYTSPGPTShPNPVLQPGSQQLPSVPTQLAHSAPYSMPdsnTSQPHsP 711
Cdd:PRK10263 329 ATQSWAAPVEPVTQTPPVASVDVPPA-QPTVAWQPVPGPQT-GEPVIAPAPEGYPQQSQYAQPAVQYNEP---LQQPV-Q 402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 712 PKNPFAHVASVSEPSQRPSTETPYLPVG-GAYQPNISSPPNDIQFAPPRRSQTQSPGKqssgpilTQTAIEAYPRPASVH 790
Cdd:PRK10263 403 PQQPYYAPAAEQPAQQPYYAPAPEQPAQqPYYAPAPEQPVAGNAWQAEEQQSTFAPQS-------TYQTEQTYQQPAAQE 475
|
170
....*....|....*....
gi 1868467581 791 APSSPTKTINPYTVTQVVP 809
Cdd:PRK10263 476 PLYQQPQPVEQQPVVEPEP 494
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
344-632 |
2.83e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 42.62 E-value: 2.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 344 APASVQSSAAPVLEQRPQTAPYQAA--VPMNPYAPHQPSSSELLQGIP----NPYASTASLPATPFATP---FATPFAPP 414
Cdd:PHA03247 2814 PAAALPPAASPAGPLPPPTSAQPTAppPPPGPPPPSLPLGGSVAPGGDvrrrPPSRSPAAKPAAPARPPvrrLARPAVSR 2893
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 415 QAQTQSQGkahsfaaqsregyqspydlPDTLSRPRRPALRkvAPPTNGVPNPVPPRSSSIPAPAPPPPAMASslPDLDQR 494
Cdd:PHA03247 2894 STESFALP-------------------PDQPERPPQPQAP--PPPQPQPQPPPPPQPQPPPPPPPRPQPPLA--PTTDPA 2950
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 495 PPPSNEGHASKSFFEELPAPPPRARPgsrggRYTPQPAPVLNAPAQSMAPPPVPPVPTVPS------------AEPVA-- 560
Cdd:PHA03247 2951 GAGEPSGAVPQPWLGALVPGRVAVPR-----FRVPQPAPSREAPASSTPPLTGHSLSRVSSwasslalheetdPPPVSlk 3025
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 561 -----------DNVYQAQLQAPDRMDPYANLSVPSVPVGPGTGPRYSPKPPGGAIAgkpsvSPRYSPAPPPSQASLPGRP 629
Cdd:PHA03247 3026 qtlwppddtedSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARE-----SPSSQFGPPPLSANAALSR 3100
|
...
gi 1868467581 630 RYV 632
Cdd:PHA03247 3101 RYV 3103
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
451-647 |
4.27e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 41.79 E-value: 4.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 451 PALRKVAPPTNGVPNPVPPRSSSIPAPAPPPPAMASslPDLDQRPPPSNEGHASKSFFEELPAPPPRARPGSRGGRYTPQ 530
Cdd:PRK12323 374 PATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAA--PAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPA 451
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 531 PAPV------LNAPAQSMAPPPVPPVPTVPSAEPVADNVYQAQLQAPDRMDPyANLSVPSvPVGPGTGPRYSPKPPGGAI 604
Cdd:PRK12323 452 PAPAaapaaaARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELP-PEFASPA-PAQPDAAPAGWVAESIPDP 529
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1868467581 605 AGKPSVSPRYSPAPPPSQASLPgRPRYVSQPANLPFQPRTSSP 647
Cdd:PRK12323 530 ATADPDDAFETLAPAPAAAPAP-RAAAATEPVVAPRPPRASAS 571
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
294-672 |
4.97e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.08 E-value: 4.97e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 294 SPIEESPADAKFG-DTVINEEEEDLAARWEAELDDDDELLLAEDTTTETQEAPASVQSSAAPVLEQRPQTAPYQAAVPMN 372
Cdd:PHA03307 26 ATPGDAADDLLSGsQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAREGS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 373 PYAPHQPSSSELLQGIPNpyASTASLPATPFATPFATPFAPPQAQTQSQGKAHSFAAQSREGYQSPYDLPDTLSRPRRPA 452
Cdd:PHA03307 106 PTPPGPSSPDPPPPTPPP--ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 453 lrkVAPPTNGVPNPV-PPRSSSIPAPAPPPPAMASSLPDLDQRPPPSNEGHASKSFFEELPAPPPRARPGSRGGRYTPQP 531
Cdd:PHA03307 184 ---RAPSSPPAEPPPsTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRP 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 532 APVLNAPAQSMAPPPVPPVPTVPSAEPVA-DNVYQAQLQAPDRMDPYANLSVPSV---------------PVGPGTGPRY 595
Cdd:PHA03307 261 APITLPTRIWEASGWNGPSSRPGPASSSSsPRERSPSPSPSSPGSGPAPSSPRASssssssressssstsSSSESSRGAA 340
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1868467581 596 SPKPPGGAIAGKPS-VSPRYSPAPPPSQASLPGRPRYVSQPANLPFQPRTSSPLAHHEKTAYEGHPHERPYTSPGPTS 672
Cdd:PHA03307 341 VSPGPSPSRSPSPSrPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLD 418
|
|
| PRK14971 |
PRK14971 |
DNA polymerase III subunit gamma/tau; |
669-798 |
8.52e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 40.91 E-value: 8.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 669 GPTSHPNP-VLQPGSQQLPSVPTQlahsapysmPDSNTSQPHSPPKNPFAHVASVSEPSQRPSTEtpyLPVGGAYQPNIS 747
Cdd:PRK14971 374 GPKQHIKPvFTQPAAAPQPSAAAA---------ASPSPSQSSAAAQPSAPQSATQPAGTPPTVSV---DPPAAVPVNPPS 441
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 1868467581 748 SPPNDIQFAPPRRSQTQSPGKQSSGPILTQTAIEAYPRPASVHAPSSPTKT 798
Cdd:PRK14971 442 TAPQAVRPAQFKEEKKIPVSKVSSLGPSTLRPIQEKAEQATGNIKEAPTGT 492
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
583-754 |
8.99e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 41.22 E-value: 8.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 583 PSVPV-GPGTGPRYSPKPPggaIAGKPSVSPRYSPAPPPSQASLPGRPRYVSQPANLPFQPRTSSPLAHHEKTAYEghPH 661
Cdd:PRK10263 740 PHEPLfTPIVEPVQQPQQP---VAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVA--PQ 814
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1868467581 662 ERPYTSPGPTSHPNPVLQPGSQQLPSVPTQLAHsaPYSMPDSNtsqphsppknpfahvasvSEPSQRPSTETPYLPVgga 741
Cdd:PRK10263 815 PQYQQPQQPVAPQPQYQQPQQPVAPQPQDTLLH--PLLMRNGD------------------SRPLHKPTTPLPSLDL--- 871
|
170
....*....|...
gi 1868467581 742 yqpnISSPPNDIQ 754
Cdd:PRK10263 872 ----LTPPPSEVE 880
|
|
| |
