nuclear RNA export factor 1 isoform X3 [Halichoerus grypus]
leucine-rich repeat domain-containing protein( domain architecture ID 12099015)
leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions
List of domain hits
Name | Accession | Description | Interval | E-value | |||
Tap-RNA_bind | pfam09162 | Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta ... |
59-138 | 1.25e-48 | |||
Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element. : Pssm-ID: 462696 Cd Length: 80 Bit Score: 163.11 E-value: 1.25e-48
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TAP_C | smart00804 | C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF ... |
496-558 | 2.16e-31 | |||
C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for the nuclear export of mRNA. Its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate shuttling. This domain forms a compact four-helix fold related to that of a UBA domain. : Pssm-ID: 197882 Cd Length: 63 Bit Score: 115.86 E-value: 2.16e-31
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NTF2 | cd00780 | Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of ... |
322-478 | 1.75e-22 | |||
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many soluble factors that includes GDP-binding protein Ran (RanGDP). RanGDP is required for both import and export of proteins and poly(A) RNA. RanGDP also has been implicated in cell cycle control, specifically in mitotic spindle assembly. In interphase cells, RanGDP is predominately nuclear and thought to be GTP bound, but it is also present in the cytoplasm, probably in the GDP-bound state. NTF2 mediates the nuclear import of RanGDP. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. : Pssm-ID: 238403 Cd Length: 119 Bit Score: 92.73 E-value: 1.75e-22
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LRR super family | cl34836 | Leucine-rich repeat (LRR) protein [Transcription]; |
203-267 | 3.68e-06 | |||
Leucine-rich repeat (LRR) protein [Transcription]; The actual alignment was detected with superfamily member COG4886: Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 49.55 E-value: 3.68e-06
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Name | Accession | Description | Interval | E-value | |||
Tap-RNA_bind | pfam09162 | Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta ... |
59-138 | 1.25e-48 | |||
Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element. Pssm-ID: 462696 Cd Length: 80 Bit Score: 163.11 E-value: 1.25e-48
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TAP_C | smart00804 | C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF ... |
496-558 | 2.16e-31 | |||
C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for the nuclear export of mRNA. Its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate shuttling. This domain forms a compact four-helix fold related to that of a UBA domain. Pssm-ID: 197882 Cd Length: 63 Bit Score: 115.86 E-value: 2.16e-31
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UBA_TAP-C | cd14342 | UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF ... |
507-557 | 8.66e-26 | |||
UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF family of mRNA nuclear export factors including vertebrate NXF1 (also called tip-associated protein or mRNA export factor TAP), NXF2 (also called cancer/testis antigen CT39 or TAP-like protein TAPL-2), Caenorhabditis elegans NXF1 (ceNXF1), Saccharomyces cerevisiae mRNA nuclear export factor Mex67p and similar proteins. NXF proteins can stimulate nuclear export of mRNAs and facilitate the export of unspliced viral mRNA containing the constitutive transport element. It is a multi-domain protein with a nuclear localization sequence (NLS), a non-canonical mRNA-binding domain, and four leucine-rich repeats (LLR) at the N-terminal region. Its C-terminal part contains a NTF2-like domain and a ubiquitin-associated (UBA)-like domain, joined by flexible Pro-rich linker. Caenorhabditis elegans NXF1 are essential for the nuclear export of poly(A)+mRNA. In budding yeast, Mex67p binds mRNAs through its adaptor Yra1/REF. It also interacts directly with Nab2, an essential shuttling mRNA-binding protein required for export. Moreover, Mex67p associates with both nuclear pore protein (nucleoporin) FG repeats and Hpr1, a component of the TREX/THO complex linking transcription and export. Pssm-ID: 270527 Cd Length: 51 Bit Score: 99.58 E-value: 8.66e-26
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TAP_C | pfam03943 | TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling ... |
509-557 | 5.85e-25 | |||
TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. The structure of the C-terminal domain is composed of four helices. The structure is related to the UBA domain. Pssm-ID: 461102 Cd Length: 49 Bit Score: 97.22 E-value: 5.85e-25
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NTF2 | cd00780 | Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of ... |
322-478 | 1.75e-22 | |||
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many soluble factors that includes GDP-binding protein Ran (RanGDP). RanGDP is required for both import and export of proteins and poly(A) RNA. RanGDP also has been implicated in cell cycle control, specifically in mitotic spindle assembly. In interphase cells, RanGDP is predominately nuclear and thought to be GTP bound, but it is also present in the cytoplasm, probably in the GDP-bound state. NTF2 mediates the nuclear import of RanGDP. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. Pssm-ID: 238403 Cd Length: 119 Bit Score: 92.73 E-value: 1.75e-22
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NTF2 | pfam02136 | Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like ... |
326-475 | 1.02e-13 | |||
Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins. Pssm-ID: 396625 Cd Length: 116 Bit Score: 67.76 E-value: 1.02e-13
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
203-267 | 3.68e-06 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 49.55 E-value: 3.68e-06
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LRR_8 | pfam13855 | Leucine rich repeat; |
205-267 | 1.97e-05 | |||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.51 E-value: 1.97e-05
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
207-298 | 3.06e-05 | |||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.55 E-value: 3.06e-05
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Name | Accession | Description | Interval | E-value | |||
Tap-RNA_bind | pfam09162 | Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta ... |
59-138 | 1.25e-48 | |||
Tap, RNA-binding; Members of this family adopt a structure consisting of an alpha+beta sandwich with an antiparallel beta-sheet, arranged in a 2(beta-alpha-beta) motif. They are mainly found in mRNA export factors, and mediate the sequence nonspecific nuclear export of cellular mRNAs as well as the sequence-specific export of retroviral mRNAs bearing the constitutive transport element. Pssm-ID: 462696 Cd Length: 80 Bit Score: 163.11 E-value: 1.25e-48
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TAP_C | smart00804 | C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF ... |
496-558 | 2.16e-31 | |||
C-terminal domain of vertebrate Tap protein; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for the nuclear export of mRNA. Its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate shuttling. This domain forms a compact four-helix fold related to that of a UBA domain. Pssm-ID: 197882 Cd Length: 63 Bit Score: 115.86 E-value: 2.16e-31
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UBA_TAP-C | cd14342 | UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF ... |
507-557 | 8.66e-26 | |||
UBA-like domain found in nuclear RNA export factor NXF1, NXF2 and similar proteins; The NXF family of mRNA nuclear export factors including vertebrate NXF1 (also called tip-associated protein or mRNA export factor TAP), NXF2 (also called cancer/testis antigen CT39 or TAP-like protein TAPL-2), Caenorhabditis elegans NXF1 (ceNXF1), Saccharomyces cerevisiae mRNA nuclear export factor Mex67p and similar proteins. NXF proteins can stimulate nuclear export of mRNAs and facilitate the export of unspliced viral mRNA containing the constitutive transport element. It is a multi-domain protein with a nuclear localization sequence (NLS), a non-canonical mRNA-binding domain, and four leucine-rich repeats (LLR) at the N-terminal region. Its C-terminal part contains a NTF2-like domain and a ubiquitin-associated (UBA)-like domain, joined by flexible Pro-rich linker. Caenorhabditis elegans NXF1 are essential for the nuclear export of poly(A)+mRNA. In budding yeast, Mex67p binds mRNAs through its adaptor Yra1/REF. It also interacts directly with Nab2, an essential shuttling mRNA-binding protein required for export. Moreover, Mex67p associates with both nuclear pore protein (nucleoporin) FG repeats and Hpr1, a component of the TREX/THO complex linking transcription and export. Pssm-ID: 270527 Cd Length: 51 Bit Score: 99.58 E-value: 8.66e-26
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TAP_C | pfam03943 | TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling ... |
509-557 | 5.85e-25 | |||
TAP C-terminal domain; The vertebrate Tap protein is a member of the NXF family of shuttling transport receptors for nuclear export of mRNA. Tap has a modular structure, and its most C-terminal domain is important for binding to FG repeat-containing nuclear pore proteins (FG-nucleoporins) and is sufficient to mediate nuclear shuttling. The structure of the C-terminal domain is composed of four helices. The structure is related to the UBA domain. Pssm-ID: 461102 Cd Length: 49 Bit Score: 97.22 E-value: 5.85e-25
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NTF2 | cd00780 | Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of ... |
322-478 | 1.75e-22 | |||
Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many soluble factors that includes GDP-binding protein Ran (RanGDP). RanGDP is required for both import and export of proteins and poly(A) RNA. RanGDP also has been implicated in cell cycle control, specifically in mitotic spindle assembly. In interphase cells, RanGDP is predominately nuclear and thought to be GTP bound, but it is also present in the cytoplasm, probably in the GDP-bound state. NTF2 mediates the nuclear import of RanGDP. NTF2 binds to both RanGDP and FxFG repeat-containing nucleoporins. Pssm-ID: 238403 Cd Length: 119 Bit Score: 92.73 E-value: 1.75e-22
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NTF2 | pfam02136 | Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like ... |
326-475 | 1.02e-13 | |||
Nuclear transport factor 2 (NTF2) domain; This family includes the NTF2-like Delta-5-3-ketosteroid isomerase proteins. Pssm-ID: 396625 Cd Length: 116 Bit Score: 67.76 E-value: 1.02e-13
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NTF2_like | cd00531 | Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 ... |
330-475 | 8.81e-10 | |||
Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of divergent evolution wherein the proteins have many common structural details but diverge greatly in their function. For example, nuclear transport factor 2 (NTF2) mediates the nuclear import of RanGDP and binds to both RanGDP and FxFG repeat-containing nucleoporins while Ketosteroid isomerases catalyze the isomerization of delta-5-3-ketosteroid to delta-4-3-ketosteroid, by intramolecular transfer of the C4-beta proton to the C6-beta position. While the function of the beta sub-unit of the Ring hydroxylating dioxygenases is not known, Scytalone Dehydratases catalyzes two reactions in the biosynthetic pathway that produces fungal melanin. Members of the NTF2-like superfamily are widely distributed among bacteria, archaea and eukaryotes. Pssm-ID: 238296 [Multi-domain] Cd Length: 124 Bit Score: 56.75 E-value: 8.81e-10
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
203-267 | 3.68e-06 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 49.55 E-value: 3.68e-06
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
203-292 | 8.28e-06 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 48.39 E-value: 8.28e-06
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
203-269 | 1.00e-05 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 48.01 E-value: 1.00e-05
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LRR_8 | pfam13855 | Leucine rich repeat; |
205-267 | 1.97e-05 | |||
Leucine rich repeat; Pssm-ID: 404697 [Multi-domain] Cd Length: 61 Bit Score: 42.51 E-value: 1.97e-05
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PPP1R42 | cd21340 | protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ... |
207-298 | 3.06e-05 | |||
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation. Pssm-ID: 411060 [Multi-domain] Cd Length: 220 Bit Score: 45.55 E-value: 3.06e-05
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LRR | COG4886 | Leucine-rich repeat (LRR) protein [Transcription]; |
202-267 | 3.87e-04 | |||
Leucine-rich repeat (LRR) protein [Transcription]; Pssm-ID: 443914 [Multi-domain] Cd Length: 414 Bit Score: 43.00 E-value: 3.87e-04
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
231-273 | 3.93e-04 | |||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 38.38 E-value: 3.93e-04
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LRR_4 | pfam12799 | Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ... |
205-241 | 9.85e-03 | |||
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains. Pssm-ID: 463713 [Multi-domain] Cd Length: 44 Bit Score: 34.14 E-value: 9.85e-03
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Blast search parameters | ||||
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