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Conserved domains on  [gi|1907175931|ref|XP_036008389|]
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zinc finger protein 850 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-636 3.01e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 3.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 244 YDKKPFQCKECGSAFTVLAQLITQpQNIHNGKKSFECKQCG---KIFSNGSYHIQHQSIHSSEKAFGCHVCGKAFRLQVY 320
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRH-IRSHTGEKPSQCSYSGcdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 321 LSEHQKTHTDEKPFKCNLCGSVFRRKYHLTEHQRIHTDVKLYQCKECgklFRRRSNFMEHQSIHTNVKPFkcELCGSAFR 400
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN---NSSSVNTPQSNSLHPPLPAN--SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 401 LQSLLSqHQRIHTDEKPYQCKECGKFFRRRSNFTEHLSIHTNVKPFKCELCGSAFRLQSLLNQHQRIHTGEKPYQCKECG 480
Cdd:COG5048   183 NLSLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 481 KFFRRSSNFTEHRSIHTNV-------KPFKCELCGSAFRLQSLLSQHQR--IHTGE--KPYQCKE--CGKFFRRRSNFTE 547
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 548 HLSIHTNVKPFKCELCGSDFRLQSLLN-------QHQRIHTGEKPYQC--KECGKFFRRSSNFTEHLSIHTGKKP--FDC 616
Cdd:COG5048   342 HILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKN 421

                         410       420
                  ....*....|....*....|
gi 1907175931 617 NKCGKVFRLNIHLIRHQRFH 636
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIH 441
KRAB super family cl42959
krueppel associated box;
18-40 1.32e-05

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 42.96  E-value: 1.32e-05
                           10        20
                   ....*....|....*....|...
gi 1907175931   18 SMGSCISKPDLIVLLEQEKELWM 40
Cdd:smart00349  39 SLGFQVPKPDLISQLEQGEEPWI 61
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 221-243 9.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.85e-03
                          10        20
                  ....*....|....*....|...
gi 1907175931 221 YECNECGKAFNRRSNFMRHQKVH 243
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-636 3.01e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 3.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 244 YDKKPFQCKECGSAFTVLAQLITQpQNIHNGKKSFECKQCG---KIFSNGSYHIQHQSIHSSEKAFGCHVCGKAFRLQVY 320
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRH-IRSHTGEKPSQCSYSGcdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 321 LSEHQKTHTDEKPFKCNLCGSVFRRKYHLTEHQRIHTDVKLYQCKECgklFRRRSNFMEHQSIHTNVKPFkcELCGSAFR 400
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN---NSSSVNTPQSNSLHPPLPAN--SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 401 LQSLLSqHQRIHTDEKPYQCKECGKFFRRRSNFTEHLSIHTNVKPFKCELCGSAFRLQSLLNQHQRIHTGEKPYQCKECG 480
Cdd:COG5048   183 NLSLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 481 KFFRRSSNFTEHRSIHTNV-------KPFKCELCGSAFRLQSLLSQHQR--IHTGE--KPYQCKE--CGKFFRRRSNFTE 547
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 548 HLSIHTNVKPFKCELCGSDFRLQSLLN-------QHQRIHTGEKPYQC--KECGKFFRRSSNFTEHLSIHTGKKP--FDC 616
Cdd:COG5048   342 HILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKN 421

                         410       420
                  ....*....|....*....|
gi 1907175931 617 NKCGKVFRLNIHLIRHQRFH 636
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIH 441
KRAB smart00349
krueppel associated box;
18-40 1.32e-05

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 42.96  E-value: 1.32e-05
                           10        20
                   ....*....|....*....|...
gi 1907175931   18 SMGSCISKPDLIVLLEQEKELWM 40
Cdd:smart00349  39 SLGFQVPKPDLISQLEQGEEPWI 61
zf-H2C2_2 pfam13465
Zinc-finger double domain;
461-485 7.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.26e-04
                          10        20
                  ....*....|....*....|....*
gi 1907175931 461 LNQHQRIHTGEKPYQCKECGKFFRR 485
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 221-243 9.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.85e-03
                          10        20
                  ....*....|....*....|...
gi 1907175931 221 YECNECGKAFNRRSNFMRHQKVH 243
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
244-636 3.01e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 3.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 244 YDKKPFQCKECGSAFTVLAQLITQpQNIHNGKKSFECKQCG---KIFSNGSYHIQHQSIHSSEKAFGCHVCGKAFRLQVY 320
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRH-IRSHTGEKPSQCSYSGcdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASS 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 321 LSEHQKTHTDEKPFKCNLCGSVFRRKYHLTEHQRIHTDVKLYQCKECgklFRRRSNFMEHQSIHTNVKPFkcELCGSAFR 400
Cdd:COG5048   108 SSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGN---NSSSVNTPQSNSLHPPLPAN--SLSKDPSS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 401 LQSLLSqHQRIHTDEKPYQCKECGKFFRRRSNFTEHLSIHTNVKPFKCELCGSAFRLQSLLNQHQRIHTGEKPYQCKECG 480
Cdd:COG5048   183 NLSLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 481 KFFRRSSNFTEHRSIHTNV-------KPFKCELCGSAFRLQSLLSQHQR--IHTGE--KPYQCKE--CGKFFRRRSNFTE 547
Cdd:COG5048   262 RSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 548 HLSIHTNVKPFKCELCGSDFRLQSLLN-------QHQRIHTGEKPYQC--KECGKFFRRSSNFTEHLSIHTGKKP--FDC 616
Cdd:COG5048   342 HILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKN 421

                         410       420
                  ....*....|....*....|
gi 1907175931 617 NKCGKVFRLNIHLIRHQRFH 636
Cdd:COG5048   422 PPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
191-599 8.92e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.72  E-value: 8.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 191 RPFECNECGKFFKHGSSLVQHKIIHAGVKPYECN--ECGKAFNRRSNFMRHQ-KVHYDKKPFQCKECGSAFTVLAqlitQ 267
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLrTHHNNPSDLNSKSLPLSNSKAS----S 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 268 PQNIHNGKKSFECKQC-GKIFSNGSYHIQHQSIHSSEKAFGC--HVC-GKAFRLQVYLSEHQKTHTDEKPFKCNLCGSVF 343
Cdd:COG5048   108 SSLSSSSSNSNDNNLLsSHSLPPSSRDPQLPDLLSISNLRNNplPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 344 RrkyhlteHQRIHTDVKLYQCKECGKLFRRRSNFMEHQSIHTNVKPFKCELCGSAFRLQSLLSQHQRIHTDEKPYQCKEC 423
Cdd:COG5048   188 I-------SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 424 GKFFRRRSNFTEHLSIHTNV-------KPFKCELCGSAFRLQSLLNQHQR--IHTGE--KPYQCKE--CGKFFRRSSNFT 490
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 491 EHRSIHTNVKPFKCELCGSAFRLQSLL-------SQHQRIHTGEKPYQC--KECGKFFRRRSNFTEHLSIHTNVKP--FK 559
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1907175931 560 CELCGSDFRLQSLLNQHQRIHTGEKPYQCKECGKFFRRSS 599
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
317-637 9.52e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 9.52e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 317 LQVYLSEHQKTHTDEKPFKCNLCGSVFRRKYHLTEHQRIHTDVKLYQC--KECGKLFRRRSNFMEHQSIHTNVKPFKCE- 393
Cdd:COG5048    17 SSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSk 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 394 ---------------LCGSAFRLQSLLSQHQ-------------RIHTDEKPYQCKECGKFFRRRSNFTEHLSIHTNVKP 445
Cdd:COG5048    97 slplsnskasssslsSSSSNSNDNNLLSSHSlppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 446 FKCELCGSAFRLqsllnqHQRIHTGEKPYQCKECGKFFRRSSNFTEHRSIHTNVKPFKCELCGSAFRLQSLLSQHQRIHT 525
Cdd:COG5048   177 SKDPSSNLSLLI------SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 526 GEKPYQCKECGKFFRRRSNFTEHLSIHTNV-------KPFKCELCGSDFRLQSLLNQHQR--IHTGE--KPYQCKE--CG 592
Cdd:COG5048   251 SDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCG 330

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1907175931 593 KFFRRSSNFTEHLSIHTGKKPFDC--NKCGKVFRLNIHLIRHQRFHN 637
Cdd:COG5048   331 KLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQ 377
KRAB smart00349
krueppel associated box;
18-40 1.32e-05

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 42.96  E-value: 1.32e-05
                           10        20
                   ....*....|....*....|...
gi 1907175931   18 SMGSCISKPDLIVLLEQEKELWM 40
Cdd:smart00349  39 SLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
380-650 2.49e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 380 HQSIHTNVKPFKCELCGSAFRLQSLLSQHQRIHTDEKPYQC--KECGKFFRRRSNFTEHLSIHTNVKPFKCE-------- 449
Cdd:COG5048    24 LKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsns 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 450 --------LCGSAFRLQSLLNQHQ-------------RIHTGEKPYQCKECGKFFRRSSNFTEHRSIHTNVKPFKCELCG 508
Cdd:COG5048   104 kasssslsSSSSNSNDNNLLSSHSlppssrdpqlpdlLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 509 SAFRLqsllsqHQRIHTGEKPYQCKECGKFFRRRSNFTEHLSIHTNVKPFKCELCGSDFRLQSLLNQHQRIHTGEKPYQC 588
Cdd:COG5048   184 LSLLI------SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSA 257

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907175931 589 KECG------KFFRRSSNFTEHLSIHTGK-KPFDCNKCGKVFRLNIHLIRHQR--FHNGEKVKSVERPFIL 650
Cdd:COG5048   258 SESPrsslptASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCPYSL 328
zf-H2C2_2 pfam13465
Zinc-finger double domain;
461-485 7.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.26e-04
                          10        20
                  ....*....|....*....|....*
gi 1907175931 461 LNQHQRIHTGEKPYQCKECGKFFRR 485
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
573-597 7.26e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.26e-04
                          10        20
                  ....*....|....*....|....*
gi 1907175931 573 LNQHQRIHTGEKPYQCKECGKFFRR 597
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
517-541 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*
gi 1907175931 517 LSQHQRIHTGEKPYQCKECGKFFRR 541
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-516 2.30e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 163 KPYECKDCGKAFRLQQHLTRHQKAHSGERPFECNECG---KFFKHGSSLVQHKIIHAGVKPYECNECGKAFNRRSNFMRH 239
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGcdkSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 240 QKVHYDKKPFQCKECGSA------FTVLAQLITQPQNIHNGKKSFECKQCGKIFSNGSYHIQHQSIHSSEKAFGCHVC-- 311
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPpssrdpQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLLISsn 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 312 -------------GKAFRLQVYLSEHQKTHTDEKPFKCNLCGSVFRRKYHLTEHQRIHTDVKLYQCKECGKLFRRRSNFM 378
Cdd:COG5048   192 vstsipsssenspLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 379 EHQSIHTNV-------KPFKCELCGSAFRLQSLLSQHQR--IHTDE--KPYQCKE--CGKFFRRRSNFTEHLSIHTNVKP 445
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 446 FKCELCGSAFRLQSLLN--------QHQRIHTGEKPYQ-------------------------------CKECGKFFRRS 486
Cdd:COG5048   352 AKEKLLNSSSKFSPLLNneppqslqQYKDLKNDKKSETlsnscirnfkrdsnlslhiithlsfrpynckNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|
gi 1907175931 487 SNFTEHRSIHTNVKPFKCELCGSAFRLQSL 516
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-429 5.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.13e-03
                          10        20
                  ....*....|....*....|....*
gi 1907175931 405 LSQHQRIHTDEKPYQCKECGKFFRR 429
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
155-404 7.30e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 7.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 155 HHSVHTGEKPYECKDCGKAFRLQQHLTRHQKAHSGERPFECNECGKFFKHGSSLVQHKIIHAGVKPYECNECGKAFNRRS 234
Cdd:COG5048   189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 235 NFMRHQKVHYD-------KKPFQCKECGSAFTVLAQLITQ-PQNIHNGK--KSFEC--KQCGKIFSNGSYHIQHQSIHSS 302
Cdd:COG5048   269 SSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHlRSVNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907175931 303 EKAFGCHVC-------GKAFRLQVYLSEHQKTHTDEKPFKC--NLCGSVFRRKYHLTEHQRIHTDVKLYQCK--ECGKLF 371
Cdd:COG5048   349 ISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         250       260       270
                  ....*....|....*....|....*....|...
gi 1907175931 372 RRRSNFMEHQSIHTNVKPFKCELCGSAFRLQSL 404
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 221-243 9.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 9.85e-03
                          10        20
                  ....*....|....*....|...
gi 1907175931 221 YECNECGKAFNRRSNFMRHQKVH 243
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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