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Conserved domains on  [gi|1907177138|ref|XP_036008530|]
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7-dehydrocholesterol reductase isoform X4 [Mus musculus]

Protein Classification

phosphatidylethanolamine N-methyltransferase family domain-containing protein( domain architecture ID 229533)

phosphatidylethanolamine N-methyltransferase (PEMT) family domain-containing protein similar to Homo sapiens PEMT, which catalyzes the three sequential steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME), PMME to phosphatidyldimethylethanolamine (PDME), and PDME to phosphatidylcholine (PC)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ICMT super family cl21511
Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine ...
 17-373 1.26e-79

Isoprenylcysteine carboxyl methyltransferase (ICMT) family; The isoprenylcysteine o-methyltransferase (EC:2.1.1.100) family carry out carboxyl methylation of cleaved eukaryotic proteins that terminate in a CaaX motif. In Saccharomyces cerevisiae this methylation is carried out by Ste14p, an integral endoplasmic reticulum membrane protein. Ste14p is the founding member of the isoprenylcysteine carboxyl methyltransferase (ICMT) family, whose members share significant sequence homology.


The actual alignment was detected with superfamily member pfam01222:

Pssm-ID: 473892  Cd Length: 429  Bit Score: 250.43  E-value: 1.26e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138  17 HRFLPGYVggvQEGAITPAGVVNKYEVNGLQAWLITHILWFVnAYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIK 96
Cdd:pfam01222  85 YLTLPGKV---VEGLPLSNGRKLPYKINAFWSFLLTLAAIGV-LHYTQLFELTYLYDNFVQIMSSAILFSFALAIYLYVR 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138  97 GYLFPTSAEDC--KFTGNFFYNYMMGIEFNPRIGKwFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVL 174
Cdd:pfam01222 161 SLKAPEEDKDApgGNSGNLIYDFFIGRELNPRIGS-LDIKMFFELRPGLLGWVFINLAALLKQYETYGYVTPSLLFVLLN 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138 175 QAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPN-ALGILLLGLVGYYIFRMTN 253
Cdd:pfam01222 240 QLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGWSTyAVAIYALLLCGYYIFRSAN 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138 254 HQKDLFRRTDGrcLIWGKKPKAIECsytsadglKHHSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIY 333
Cdd:pfam01222 320 SQKNNFRTNPA--DPKLIYLKYIQT--------KTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFNSVLPYFYPLY 389

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1907177138 334 MTILLTHRCLRDEHRCANKYGRDWERYTAAVPYRLLPGIF 373
Cdd:pfam01222 390 FAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
17-373 1.26e-79

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 250.43  E-value: 1.26e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138  17 HRFLPGYVggvQEGAITPAGVVNKYEVNGLQAWLITHILWFVnAYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIK 96
Cdd:pfam01222  85 YLTLPGKV---VEGLPLSNGRKLPYKINAFWSFLLTLAAIGV-LHYTQLFELTYLYDNFVQIMSSAILFSFALAIYLYVR 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138  97 GYLFPTSAEDC--KFTGNFFYNYMMGIEFNPRIGKwFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVL 174
Cdd:pfam01222 161 SLKAPEEDKDApgGNSGNLIYDFFIGRELNPRIGS-LDIKMFFELRPGLLGWVFINLAALLKQYETYGYVTPSLLFVLLN 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138 175 QAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPN-ALGILLLGLVGYYIFRMTN 253
Cdd:pfam01222 240 QLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGWSTyAVAIYALLLCGYYIFRSAN 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138 254 HQKDLFRRTDGrcLIWGKKPKAIECsytsadglKHHSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIY 333
Cdd:pfam01222 320 SQKNNFRTNPA--DPKLIYLKYIQT--------KTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFNSVLPYFYPLY 389

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1907177138 334 MTILLTHRCLRDEHRCANKYGRDWERYTAAVPYRLLPGIF 373
Cdd:pfam01222 390 FAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Name Accession Description Interval E-value
ERG4_ERG24 pfam01222
Ergosterol biosynthesis ERG4/ERG24 family;
17-373 1.26e-79

Ergosterol biosynthesis ERG4/ERG24 family;


Pssm-ID: 250456  Cd Length: 429  Bit Score: 250.43  E-value: 1.26e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138  17 HRFLPGYVggvQEGAITPAGVVNKYEVNGLQAWLITHILWFVnAYLLSWFSPTIIFDNWIPLLWCANILGYAVSTFAMIK 96
Cdd:pfam01222  85 YLTLPGKV---VEGLPLSNGRKLPYKINAFWSFLLTLAAIGV-LHYTQLFELTYLYDNFVQIMSSAILFSFALAIYLYVR 160

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138  97 GYLFPTSAEDC--KFTGNFFYNYMMGIEFNPRIGKwFDFKLFFNGRPGIVAWTLINLSFAAKQQELYGHVTNSMILVNVL 174
Cdd:pfam01222 161 SLKAPEEDKDApgGNSGNLIYDFFIGRELNPRIGS-LDIKMFFELRPGLLGWVFINLAALLKQYETYGYVTPSLLFVLLN 239

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138 175 QAIYVLDFFWNETWYLKTIDICHDHFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPN-ALGILLLGLVGYYIFRMTN 253
Cdd:pfam01222 240 QLLYVFDGLKNEEAVLTTMDITTDGFGFMLAFGDLVWVPFTYSLQTRYLSVHPSELGWSTyAVAIYALLLCGYYIFRSAN 319

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907177138 254 HQKDLFRRTDGrcLIWGKKPKAIECsytsadglKHHSKLLVSGFWGVARHFNYTGDLMGSLAYCLACGGGHLLPYFYIIY 333
Cdd:pfam01222 320 SQKNNFRTNPA--DPKLIYLKYIQT--------KTGSGLLTDGWWGFARHINYLGDWLQSLSWSLPTGFNSVLPYFYPLY 389

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1907177138 334 MTILLTHRCLRDEHRCANKYGRDWERYTAAVPYRLLPGIF 373
Cdd:pfam01222 390 FAVLLVHREARDEHKCKKKYGLDWEEYCKRVPYHIIPYVY 429
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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