The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  355 KVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMN-AIAADMCTNARRVVRKS 433
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSGKKPLDPNKVQAIREYLEERFPSVDLDEDWkVCIQAINNKCRRLRRRK 80

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  20 LNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPaAVQPQSFQQILTFCYTGRLsMNMG 95
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGqeseSSVSEITLD-DVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*..
gi 1907190809  96 DQFLLIYTAGFLQIQEIMEKGTEFFLK 122
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIK 105

The BEN domain is found in diverse animal proteins; Proteins containing BEN domains are BANP/SMAR1, NAC1 and the Drosophila mod(mdg4) isoform C, the chordopoxvirus virosomal protein E5R and several proteins of polydnaviruses. Computational analysis suggests that the BEN domain mediates protein-DNA and protein-protein interactions during chromatin organisation and transcription.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  355 KVLLRRLLASFFDRNTLANSCGTGIRSSTNDPRRKPLDSRVLHAVKYYCQNFAPNFKESEMN-AIAADMCTNARRVVRKS 433
Cdd:smart01025   1 SLFARYLLRVLFPRETLANSSVTGKRSRTGGSGKKPLDPNKVQAIREYLEERFPSVDLDEDWkVCIQAINNKCRRLRRRK 80

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  25 LQGLYCDVSVVVK--GHAFKAHRAVLAASSSYFRDLFNSSrSAVVELPAAVQPQSFQQILTFCYTGRLSMNMGDQFLLIY 102
Cdd:PHA03098    5 ELQKFCDESIIIVngGGIIKVHKIILSSSSEYFKKMFKNN-FKENEINLNIDYDSFNEVIKYIYTGKINITSNNVKDILS 83

                          90       100
                  ....*....|....*....|.
gi 1907190809 103 TAGFLQIQEIMEKGTEFFLKV 123
Cdd:PHA03098   84 IANYLIIDFLINLCINYIIKI 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809   1 MAQTLQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQ 80
Cdd:cd18289     1 MSQMLHIEIPNFGNTVLGCLNEQRLMGLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELPATVPPACFQQ 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1907190809  81 ILTFCYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFFLKVSSPSCDSQ 131
Cdd:cd18289    81 ILSFCYTGKLTMAASEQLVVMYTAGFLQIQHIVERGTDLMFKVSSPHCDSQ 131

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809   5 LQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRD---LFNSSRsavVELPAAVQPQSFQQI 81
Cdd:cd18227     1 FRVEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDqvlLKNSRR---IVLPDVMNPRVFENI 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907190809  82 LTFCYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFF 120
Cdd:cd18227    78 LLSCYTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809   5 LQMEIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTF 84
Cdd:cd18220     1 IQFDVPEYSNTVLSQLNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIKNPNVFEQLLSF 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1907190809  85 CYTGRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEFF 120
Cdd:cd18220    81 CYTGRMSLQLKDVVSFLTAASFLQMQCVIDKCTQIL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  29 YCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPaAVQPQSFQQILTFCYTGRLSMNMGDQFLLIYTA 104
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSgmkeSSSSEIELD-DVSPEAFEALLDYIYTGELELSEENVEELLAAA 79

                  ...
gi 1907190809 105 GFL 107
Cdd:cd18186    80 DKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809   8 EIPNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSaVVELPAAvQPQSFQQILTFCYT 87
Cdd:cd18206     1 DFPQHSQHVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVDQKD-VVHLDIS-NAAGLGQVLEFMYT 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907190809  88 GRLSMNMGDQFLLIYTAGFLQIQEIMEKGTEF 119
Cdd:cd18206    79 AKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  12 FGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAVQPQSFQQILTFCYTGRLS 91
Cdd:cd18200     1 YSSALLETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLNDTNCLVLPSVIEAAAFENLLQLIYSGRLT 80

                          90       100
                  ....*....|....*....|....*..
gi 1907190809  92 MNMGDQFLLIYTAGFLQIQEIMEKGTE 118
Cdd:cd18200    81 LCMDALPSHLLVASGLQMWQVVDRCSE 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  10 PNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPaAVQPQSFQQILTFC 85
Cdd:cd18198     6 PDHSSEILSGLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSgavvDQQNVYEID-FVSPEALTALLEFA 84

                          90       100
                  ....*....|....*....|....*..
gi 1907190809  86 YTGRLSMNMGDQFLLIYTAGFLQIQEI 112
Cdd:cd18198    85 YTATLTVSTANVGDILSAARLLEIPCV 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  15 SILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF--NSSRSAVVELPAAVQPQSFQQILTFCYTGRLSM 92
Cdd:cd18278    17 NILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALvgQTENDLVVSLPEEVTARGFGPLLQFAYTAKLLL 96

                          90       100
                  ....*....|....*....|
gi 1907190809  93 NMGDQFLLIYTAGFLQIQEI 112
Cdd:cd18278    97 SRENIQEVIRCAEFLRMHNL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  14 NSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPaAVQPQSFQQILTFCYTGR 89
Cdd:cd18223     3 DTVLSCLNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAFSSqeiwISSHVLELP-DLKAEVFAEILNFIYSSK 81

                  ...
gi 1907190809  90 LSM 92
Cdd:cd18223    82 VVV 84

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  14 NSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSA----VVELPaAVQPQSFQQILTFCYTGR 89
Cdd:cd18306     3 ESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGesilTVKLD-GLDPDAVEVLVNYAYTSR 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1907190809  90 LSMNmGDQFLLIY-TAGFLQIQEIMEKGTEFFLKVSSP-SC 128
Cdd:cd18306    82 LEVP-ADLVKSVYsAAKKLKMDRVKKACGDFLLEKLTPqNC 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  16 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAAV----QPQSFQQILTFCYTGRLS 91
Cdd:cd18329     8 LLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQPTVATfdvfSPDTFTIILDFVYSGKLS 87

                          90       100
                  ....*....|....*....|..
gi 1907190809  92 MNMGDQFLLIYTAGFLQIQEIM 113
Cdd:cd18329    88 LTSQNVIEVMSAASYLQMTDVI 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  16 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSFQQILTFCYTGRLS 91
Cdd:cd18256     7 ILAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAGgmseSSKDVVQI-HGVEPDIFHILLDFIYTGVVE 85

                          90       100
                  ....*....|....*....|....*...
gi 1907190809  92 MNMGDQFLLIYTAGFLQIQEIMEKGTEF 119
Cdd:cd18256    86 VTVSNVQELLVAADMLQLTEVVEICCEF 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  10 PNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELPaAVQPQSFQQILTFC 85
Cdd:cd18328     6 PNHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAgtlaDQPYVYEID-FVTPEALSAILEFA 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1907190809  86 YTGRLSMNMGDQFLLIYTAGFLQIQ-------EIME 114
Cdd:cd18328    85 YTSTLTITTSNVKHILNAAQMLEIQciinvclEIMD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  15 SILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF----NSSRSAVVELpAAVQPQSFQQILTFCYTGRL 90
Cdd:cd18253     4 SILQVFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFcndhRESREMLVEI-NGILAEAMDCFLQYVYTGKV 82

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1907190809  91 SMNMGDQFLLIYTAGFLQIQEIMEKGTEFFLKVSSP 126
Cdd:cd18253    83 KITTENVQYLFETSSLFQISPLRDACAKFLEEQLDP 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  16 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSS---RSAVVELPAAvQPQSFQQILTFCYTGRLSM 92
Cdd:cd18233     5 LLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSssqKNDVFHLDIK-NVGGIGQILDFMYTSHLDL 83

                          90       100
                  ....*....|....*....|.
gi 1907190809  93 NMGDQFLLIYTAGFLQIQEIM 113
Cdd:cd18233    84 NQDNVQVMLDIAQCLQVQNVL 104

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  20 LNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSFQQILTFCYTGRLSMNMG 95
Cdd:cd18247    10 MEEIRRQGKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFTHdmveSKQDEITM-QGIEPSALEALINFAYSGRIAIDTS 88

                          90       100
                  ....*....|....*....|....*...
gi 1907190809  96 D-QFLLIyTAGFLQIQEIMEKGTEFFLK 122
Cdd:cd18247    89 NvQSLLV-GASFLQLQSVKDACCEFLKE 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907190809  12 FGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFnSSRSAVVELpAAVQPQSFQQILTFCYTGRL 90
Cdd:cd18219     4 YSGSLLKSLNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLF-SVAGQVVEL-NFIRADIFAEILNYIYSSKI 80

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  10 PNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELPAA----------VQPQSFQ 79
Cdd:cd18327     6 PEHSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLGAGggqdvceldfVGPEALG 85

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1907190809  80 QILTFCYTGRLSMNMGDQFLLIYTAGFLQIQEIME 114
Cdd:cd18327    86 ALLEFAYTATLTISSSNMREVLRAARLLEIPCVAD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  12 FGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSA-VVELpAAVQPQSFQQILTFCYTGRL 90
Cdd:cd18260     1 YGANLLEGLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSLqRVEL-NDISPLGLATVITYAYTGKL 79

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1907190809  91 SMNMGDQFLLIYTAGFLQIQEIMEKGTEFFLK 122
Cdd:cd18260    80 TLSLYTIGSTISAASYLQIHALVKMCCDFLMQ 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  16 ILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS-SRSAVVELpAAVQPQSFQQILTFCYTGRLSMNM 94
Cdd:cd18221     5 MLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDfTQEPLVEI-EGVSNMAFRHLIEFTYTAKLMVQG 83

                          90
                  ....*....|....*...
gi 1907190809  95 GDQFLLIYTAG-FLQIQE 111
Cdd:cd18221    84 EEEANDVWKAAeYLQMQE 101

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  15 SILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSFQQILTFCYTGRL 90
Cdd:cd18270    12 SLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSglseSKQTHVHL-RNVDAATLQIIITYAYTGNL 90

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1907190809  91 SMNMGDQFLLIYTAGFLQIQEIMEKGTEFFL-KVSSPSC 128
Cdd:cd18270    91 AINDSTVEQLYETACFLQVEDVLQRCREYLIkKINAENC 129

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  17 LECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNS----SRSAVVELpAAVQPQSFQQILTFCYTGRLSM 92
Cdd:cd18238     3 FKVLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSemaeSKQDSITI-KDIDEEAVELLVDFAYTGKLTL 81

                          90       100
                  ....*....|....*....|....*..
gi 1907190809  93 NMGDQFLLIYTAGFLQIQEIMEKGTEF 119
Cdd:cd18238    82 TVDNVQSLLYAASLLQVEEVAKACCEF 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  20 LNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF-----NSSRSAVVELPaAVQPQSFQQILTFCYTGRLSMNM 94
Cdd:cd18330     9 LNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLihyiqDSGRHSTASLD-IVTSEAFSIILDFLYSGKLDLCS 87

                          90
                  ....*....|....*....
gi 1907190809  95 GDQFLLIYTAGFLQIQEIM 113
Cdd:cd18330    88 ENVIEVMSAASYLQMTDVV 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  14 NSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLF----NSSRSAVVELPAAvQPQSFQQILTFCYTGR 89
Cdd:cd18287     7 HFLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmRESQQSEIELKDT-NAEAFKALLKYIYTGR 85

                  ...
gi 1907190809  90 LSM 92
Cdd:cd18287    86 LTL 88

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190809  10 PNFGNSILECLNEQRLQGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFnsSRSAVVEL-PAAVQPQSFQQILTFCYTG 88
Cdd:cd18216     1 PSHATQLLLQLNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLV--LHDNLIHLdQDMVSPTVFQQILDFIYTG 78