Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ...
97-445
0e+00
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.
:
Pssm-ID: 464930 Cd Length: 297 Bit Score: 547.77 E-value: 0e+00
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
561-829
3.96e-09
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
The actual alignment was detected with superfamily member pfam05109:
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 61.09 E-value: 3.96e-09
Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small ...
218-285
3.24e-04
Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; The HR1 domain, also called the ACC (anti-parallel coiled-coil) finger domain or Rho-binding domain binds small GTPases from the Rho family. It is found in Rho effector proteins including PKC-related kinases such as vertebrate PRK1 (or PKN) and yeast PKC1 protein kinases C, as well as in rhophilins and Rho-associated kinase (ROCK). Rho family members function as molecular switches, cycling between inactive and active forms, controlling a variety of cellular processes. HR1 domains may occur in repeat arrangements (PKN contains three HR1 domains), separated by a short linker region.
The actual alignment was detected with superfamily member cd11636:
Pssm-ID: 469609 Cd Length: 74 Bit Score: 40.34 E-value: 3.24e-04
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ...
97-445
0e+00
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.
Pssm-ID: 464930 Cd Length: 297 Bit Score: 547.77 E-value: 0e+00
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
561-829
3.96e-09
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 61.09 E-value: 3.96e-09
Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein ...
218-285
3.24e-04
Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1; PKN1, also called PKNalpha or Protein-kinase C-related kinase 1 (PRK1), is a serine/threonine protein kinase that is activated by the Rho family of small GTPases, and by fatty acids such as arachidonic and linoleic acids. It is expressed ubiquitously and is the most abundant PKN isoform in neurons. PKN1 is implicated in a variety of functions including cytoskeletal reorganization, cardiac cell survival, cell adhesion, and glucose transport, among others. PKN1 contains three HR1 domains, a C2 domain, and a kinase domain. This model characterizes the third HR1 domain of PKN1. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family; PKN1 binds the GTPases RhoA, RhoB, and RhoC, and can also interact weakly with Rac.
Pssm-ID: 212026 Cd Length: 74 Bit Score: 40.34 E-value: 3.24e-04
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific ...
97-445
0e+00
Filopodia upregulated, FAM65; PL48 is associated with cytotrophoblast and lineage-specific HL-60 cell differentiation. The N-terminal part of the family is found to induce the formation of filopodia. It is found in vertebrates.
Pssm-ID: 464930 Cd Length: 297 Bit Score: 547.77 E-value: 0e+00
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
561-829
3.96e-09
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 61.09 E-value: 3.96e-09
Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein ...
218-285
3.24e-04
Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1; PKN1, also called PKNalpha or Protein-kinase C-related kinase 1 (PRK1), is a serine/threonine protein kinase that is activated by the Rho family of small GTPases, and by fatty acids such as arachidonic and linoleic acids. It is expressed ubiquitously and is the most abundant PKN isoform in neurons. PKN1 is implicated in a variety of functions including cytoskeletal reorganization, cardiac cell survival, cell adhesion, and glucose transport, among others. PKN1 contains three HR1 domains, a C2 domain, and a kinase domain. This model characterizes the third HR1 domain of PKN1. HR1 domains are anti-parallel coiled-coil (ACC) domains that bind small GTPases from the Rho family; PKN1 binds the GTPases RhoA, RhoB, and RhoC, and can also interact weakly with Rac.
Pssm-ID: 212026 Cd Length: 74 Bit Score: 40.34 E-value: 3.24e-04
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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