NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907198160|ref|XP_036010919|]
View 

protocadherin Fat 3 isoform X7 [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein( domain architecture ID 10182789)

cadherin repeat domain-containing protein similar to cadherins, which are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1049-1144 2.03e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 127.43  E-value: 2.03e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1049 VGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADSLDRETTASYWLTVYATDRGVVPL 1128
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1907198160 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1152-1250 1.08e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 1.08e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1152 IYYPVVMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGS 1231
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1907198160 1232 SPKQSTIWVVVQVLDENDN 1250
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-574 1.87e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 1.87e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  477 YETFVNESVRVGTNVLTVSASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEtYRFIVRASDWGSP 555
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1907198160  556 yRHESEVNVTIRVGNVNDN 574
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 733-827 3.01e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 3.01e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  733 VAVKEDMLVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKS 812
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1907198160  813 SWRLLTVNVEDANDN 827
Cdd:cd11304     84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 835-931 2.76e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 2.76e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  835 SYSVSILESSSIGTEIIQVEARDKDLGSNGEVMYSVL--TDTHQFIINSSTGIVYIADQLDRESKANYSLKIEARDKAes 912
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1907198160  913 GQQLFSVVTLKIFLDDVND 931
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 1.41e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 1.41e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  162 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 239
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1907198160  240 lyGNNGVSSTAKLYVHIERINEH 262
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1018 8.62e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 8.62e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  940 SYSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLV-NDYNGRFEVDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1258-1348 3.38e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 3.38e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1258 VYQIKLPERDrkKRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 1334
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1907198160 1335 GRPQKSSTARLHIE 1348
Cdd:cd11304     78 GGPPLSSTATVTIT 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-468 8.93e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 8.93e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  380 VYEVSISEFSPPGVLVAIVKV----SPEPLDVEYKLLPGKDSDYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGD-- 453
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 1907198160  454 ---AKAQVTIGIEDANDH 468
Cdd:cd11304     81 plsSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 592-672 4.08e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 4.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  592 PVGGHITAISAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSgiKNGNFALRITATDGEN--FADPMAI 667
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1907198160  668 NISVL 672
Cdd:cd11304     89 TITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-153 8.77e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.24  E-value: 8.77e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   47 TYNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNR 119
Cdd:cd11304      1 SYEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDR 62

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1907198160  120 EIQDNYLLIIKGSVRGED-LEAWTKVNIQVLDMND 153
Cdd:cd11304     63 EEQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1367-1461 1.58e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.69  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1367 YNFTVMESDKVTEIVGVVSVQ----PANTPLWFDIVGGkHAREMFYIlqtacgqncsteggnfDSSFdaekgvGTIVIAK 1442
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-NEDGLFSI----------------DPST------GEITTAK 58

                           90
                   ....*....|....*....
gi 1907198160 1443 PLDAEQRSVYNMSVEVTDG 1461
Cdd:cd11304     59 PLDREEQSSYTLTVTATDG 77
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 286-373 1.23e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 1.23e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   286 TVDDLDEGANGEIeSLSIVDGDPLEQFFLAKEGKWlneykVKERRQVDWESFSYgYNLTIQAKDKGSPQKFSELkTVHI- 364
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETGE-----ITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTA-TVTIt 72

                            90
                    ....*....|..
gi 1907198160   365 ---ANprrDNTP 373
Cdd:smart00112   73 vldVN---DNAP 81
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1049-1144 2.03e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 127.43  E-value: 2.03e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1049 VGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADSLDRETTASYWLTVYATDRGVVPL 1128
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1907198160 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1152-1250 1.08e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 1.08e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1152 IYYPVVMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGS 1231
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1907198160 1232 SPKQSTIWVVVQVLDENDN 1250
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-574 1.87e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 1.87e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  477 YETFVNESVRVGTNVLTVSASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEtYRFIVRASDWGSP 555
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1907198160  556 yRHESEVNVTIRVGNVNDN 574
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 733-827 3.01e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 3.01e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  733 VAVKEDMLVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKS 812
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1907198160  813 SWRLLTVNVEDANDN 827
Cdd:cd11304     84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1066-1146 2.49e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 106.66  E-value: 2.49e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  1066 TAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADSLDRETTASYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1145
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1907198160  1146 P 1146
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 835-931 2.76e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 2.76e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  835 SYSVSILESSSIGTEIIQVEARDKDLGSNGEVMYSVL--TDTHQFIINSSTGIVYIADQLDRESKANYSLKIEARDKAes 912
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1907198160  913 GQQLFSVVTLKIFLDDVND 931
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 1.41e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 1.41e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  162 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 239
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1907198160  240 lyGNNGVSSTAKLYVHIERINEH 262
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1171-1252 3.09e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.50  E-value: 3.09e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  1171 QAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGSSPKQSTIWVVVQVLDENDN 1250
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1907198160  1251 RP 1252
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1018 8.62e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 8.62e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  940 SYSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLV-NDYNGRFEVDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80
Cadherin pfam00028
Cadherin domain;
1049-1139 2.90e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 2.90e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1049 VGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADSLDRETTASYWLTVYATDRGVVPL 1128
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1907198160 1129 YSTIEVYIEVE 1139
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1157-1245 6.18e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 6.18e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1157 VMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTSRkLDREQQAEHFLEVTVTDGGSSPKQS 1236
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1907198160 1237 TIWVVVQVL 1245
Cdd:pfam00028   84 TATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 749-829 1.04e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 1.04e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   749 KAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKSSWRLLTVNVEDANDNN 828
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1907198160   829 P 829
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-576 5.14e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 5.14e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   495 SASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEtYRFIVRASDWGSPyRHESEVNVTIRVGNVND 573
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1907198160   574 NSP 576
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1258-1348 3.38e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 3.38e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1258 VYQIKLPERDrkKRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 1334
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1907198160 1335 GRPQKSSTARLHIE 1348
Cdd:cd11304     78 GGPPLSSTATVTIT 91
Cadherin pfam00028
Cadherin domain;
477-568 1.17e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 1.17e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  477 YETFVNESVRVGTNVLTVSASDKDKGENGYITYSIASLNLLP-FAINQFTGVISTTEELDFEsSPETYRFIVRASDWGSP 555
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1907198160  556 YRhESEVNVTIRV 568
Cdd:pfam00028   80 PL-SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 855-934 4.94e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 4.94e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   855 ARDKDLGSNGEVMYSVL--TDTHQFIINSSTGIVYIADQLDRESKANYSLKIEARDKAesGQQLFSVVTLKIFLDDVNDC 932
Cdd:smart00112    2 ATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1907198160   933 SP 934
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
836-924 5.46e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 5.46e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  836 YSVSILESSSIGTEIIQVEARDKDLGSNGEVMYSVLTDT--HQFIINSSTGIVYIADQLDRESKANYSLKIEARDkaESG 913
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD--SGG 78

                           90
                   ....*....|.
gi 1907198160  914 QQLFSVVTLKI 924
Cdd:pfam00028   79 PPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
941-1018 1.70e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 1.70e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907198160  941 YSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLVNDYNGR-FEVDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
733-822 6.88e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 6.88e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  733 VAVKEDMLVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKS 812
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1907198160  813 SWRLLTVNVE 822
Cdd:pfam00028   83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-468 8.93e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 8.93e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  380 VYEVSISEFSPPGVLVAIVKV----SPEPLDVEYKLLPGKDSDYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGD-- 453
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 1907198160  454 ---AKAQVTIGIEDANDH 468
Cdd:cd11304     81 plsSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1259-1348 4.68e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 4.68e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1259 YQIKLPERDRkkRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDNG 1335
Cdd:pfam00028    1 YSASVPENAP--VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdreSIGEY-ELTVEATDSG 77

                           90
                   ....*....|...
gi 1907198160 1336 RPQKSSTARLHIE 1348
Cdd:pfam00028   78 GPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1280-1348 1.50e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 1.50e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907198160  1280 AFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYDiLTIKAVDNGRPQKSSTARLHIE 1348
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-264 1.54e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 1.54e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   181 TATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKlygnnGVSSTAKLYVHIER 258
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-----PLSSTATVTITVLD 75


                    ....*.
gi 1907198160   259 INEHAP 264
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
163-257 2.98e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.33  E-value: 2.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  163 YSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmkl 240
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*..
gi 1907198160  241 yGNNGVSSTAKLYVHIE 257
Cdd:pfam00028   77 -GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 962-1018 4.28e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 4.28e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907198160   962 DPDLGLGGQVRYSLV-NDYNGRFEVDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:smart00112    4 DADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP 61
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 395-470 1.55e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 1.55e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   395 VAIVKVSPEPLDVEYKLLPGKDSDYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGD-----AKAQVTIGIEDANDHT 469
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpplsSTATVTITVLDVNDNA 80


                    .
gi 1907198160   470 P 470
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 592-672 4.08e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 4.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  592 PVGGHITAISAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSgiKNGNFALRITATDGEN--FADPMAI 667
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1907198160  668 NISVL 672
Cdd:cd11304     89 TITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-153 8.77e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.24  E-value: 8.77e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   47 TYNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNR 119
Cdd:cd11304      1 SYEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDR 62

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1907198160  120 EIQDNYLLIIKGSVRGED-LEAWTKVNIQVLDMND 153
Cdd:cd11304     63 EEQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 76-156 1.46e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 1.46e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160    76 SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQDNYLLIIKGSVRGED-LEAWTKVNIQVLDM 151
Cdd:smart00112   10 NGKVTYSILSGNDDGLF-------------SIDPETGEittTKPLDREEQPEYTLTVEATDGGGPpLSSTATVTITVLDV 76


                    ....*
gi 1907198160   152 NDLRP 156
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1367-1461 1.58e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.69  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1367 YNFTVMESDKVTEIVGVVSVQ----PANTPLWFDIVGGkHAREMFYIlqtacgqncsteggnfDSSFdaekgvGTIVIAK 1442
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-NEDGLFSI----------------DPST------GEITTAK 58

                           90
                   ....*....|....*....
gi 1907198160 1443 PLDAEQRSVYNMSVEVTDG 1461
Cdd:cd11304     59 PLDREEQSSYTLTVTATDG 77
Cadherin pfam00028
Cadherin domain;
381-463 1.78e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 1.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  381 YEVSISEFSPPGVLVAIVKVSPEPLD----VEYKLLPGKDSDYFKINPRSGLIVTAQPLNTVKKEVYKLEV--SDKEGDA 454
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVeaTDSGGPP 80

                           90
                   ....*....|..
gi 1907198160  455 K---AQVTIGIE 463
Cdd:pfam00028   81 LsstATVTITVL 92
Cadherin pfam00028
Cadherin domain;
592-672 4.46e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.52  E-value: 4.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  592 PVGGHITAISAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSLmnSGIKNGNFALRITATD--GENFADPMAI 667
Cdd:pfam00028   10 PVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDsgGPPLSSTATV 87


                   ....*
gi 1907198160  668 NISVL 672
Cdd:pfam00028   88 TITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 286-373 1.23e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 1.23e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   286 TVDDLDEGANGEIeSLSIVDGDPLEQFFLAKEGKWlneykVKERRQVDWESFSYgYNLTIQAKDKGSPQKFSELkTVHI- 364
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETGE-----ITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTA-TVTIt 72

                            90
                    ....*....|..
gi 1907198160   365 ---ANprrDNTP 373
Cdd:smart00112   73 vldVN---DNAP 81
Cadherin pfam00028
Cadherin domain;
1367-1461 5.13e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 5.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1367 YNFTVMESDKVTEIVGVVSVQPANTPLwfdivggkHAREMFYILqtacgqncsteGGNFDSSFDAEKGVGTIVIAKPLDA 1446
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP--------NGRIFYSIL-----------GGGPGGNFRIDPDTGDISTTKPLDR 61

                           90
                   ....*....|....*
gi 1907198160 1447 EQRSVYNMSVEVTDG 1461
Cdd:pfam00028   62 ESIGEYELTVEATDS 76
Cadherin pfam00028
Cadherin domain;
283-364 5.99e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 5.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  283 AVVTVDDLDEGANGEIeSLSIVDGDPLEQFFLAKEGKWLneykvKERRQVDWESFSYgYNLTIQAKDKGSPQKFSELkTV 362
Cdd:pfam00028   16 LTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDTGDI-----STTKPLDRESIGE-YELTVEATDSGGPPLSSTA-TV 87


                   ..
gi 1907198160  363 HI 364
Cdd:pfam00028   88 TI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 601-658 3.94e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.41  E-value: 3.94e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   601 SAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSgiKNGNFALRITATDG 658
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDG 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1422-1461 9.71e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 39.26  E-value: 9.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907198160  1422 GGNFDSSFDAEKGVGTIVIAKPLDAEQRSVYNMSVEVTDG 1461
Cdd:smart00112   19 SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG 58
Cadherin pfam00028
Cadherin domain;
48-149 3.80e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   48 YNATVYENSAARTYVNsqsRMGITLIDLS--WDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQ 122
Cdd:pfam00028    1 YSASVPENAPVGTEVL---TVTATDPDLGpnGRIFYSILGGGPGGNF-------------RIDPDTGDistTKPLDRESI 64

                           90       100
                   ....*....|....*....|....*...
gi 1907198160  123 DNYLLIIKGSVRGE-DLEAWTKVNIQVL 149
Cdd:pfam00028   65 GEYELTVEATDSGGpPLSSTATVTITVL 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1049-1144 2.03e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 127.43  E-value: 2.03e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1049 VGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADSLDRETTASYWLTVYATDRGVVPL 1128
Cdd:cd11304      3 EVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPL 82

                           90
                   ....*....|....*.
gi 1907198160 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd11304     83 SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1152-1250 1.08e-33

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 125.12  E-value: 1.08e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1152 IYYPVVMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGS 1231
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATDGGG 79

                           90
                   ....*....|....*....
gi 1907198160 1232 SPKQSTIWVVVQVLDENDN 1250
Cdd:cd11304     80 PPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 477-574 1.87e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 110.48  E-value: 1.87e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  477 YETFVNESVRVGTNVLTVSASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEtYRFIVRASDWGSP 555
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNeDGLFSIDPSTGEITTAKPLDREEQSS-YTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1907198160  556 yRHESEVNVTIRVGNVNDN 574
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 733-827 3.01e-28

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 109.71  E-value: 3.01e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  733 VAVKEDMLVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKS 812
Cdd:cd11304      4 VSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                           90
                   ....*....|....*
gi 1907198160  813 SWRLLTVNVEDANDN 827
Cdd:cd11304     84 STATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1066-1146 2.49e-27

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 106.66  E-value: 2.49e-27
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  1066 TAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADSLDRETTASYWLTVYATDRGVVPLYSTIEVYIEVEDVNDNA 1145
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1907198160  1146 P 1146
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 835-931 2.76e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 107.01  E-value: 2.76e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  835 SYSVSILESSSIGTEIIQVEARDKDLGSNGEVMYSVL--TDTHQFIINSSTGIVYIADQLDRESKANYSLKIEARDKAes 912
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-- 78

                           90
                   ....*....|....*....
gi 1907198160  913 GQQLFSVVTLKIFLDDVND 931
Cdd:cd11304     79 GPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 162-262 1.41e-25

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.01  E-value: 1.41e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  162 TYSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmk 239
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsgNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG--- 77

                           90       100
                   ....*....|....*....|...
gi 1907198160  240 lyGNNGVSSTAKLYVHIERINEH 262
Cdd:cd11304     78 --GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1171-1252 3.09e-25

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 100.50  E-value: 3.09e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  1171 QAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGSSPKQSTIWVVVQVLDENDN 1250
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                    ..
gi 1907198160  1251 RP 1252
Cdd:smart00112   80 AP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 940-1018 8.62e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 97.00  E-value: 8.62e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  940 SYSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLV-NDYNGRFEVDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVsGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80
Cadherin pfam00028
Cadherin domain;
1049-1139 2.90e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 95.45  E-value: 2.90e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1049 VGSVKENSRIGTSVLQVTAHDEDSGRDGEIQYSIRDGSGLGRFNIDDESGVITAADSLDRETTASYWLTVYATDRGVVPL 1128
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPL 81

                           90
                   ....*....|.
gi 1907198160 1129 YSTIEVYIEVE 1139
Cdd:pfam00028   82 SSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1157-1245 6.18e-23

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 94.29  E-value: 6.18e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1157 VMENSPKDVSVIQIQAEDPDSGSNEKLTYRITSGNPQNFFAINIKTGLITTTSRkLDREQQAEHFLEVTVTDGGSSPKQS 1236
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKP-LDRESIGEYELTVEATDSGGPPLSS 83


                   ....*....
gi 1907198160 1237 TIWVVVQVL 1245
Cdd:pfam00028   84 TATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 749-829 1.04e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.49  E-value: 1.04e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   749 KAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKSSWRLLTVNVEDANDNN 828
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1907198160   829 P 829
Cdd:smart00112   81 P 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 495-576 5.14e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.56  E-value: 5.14e-21
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   495 SASDKDKGENGYITYSIASLN-LLPFAINQFTGVISTTEELDFESSPEtYRFIVRASDWGSPyRHESEVNVTIRVGNVND 573
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNdDGLFSIDPETGEITTTKPLDREEQPE-YTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1907198160   574 NSP 576
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1258-1348 3.38e-20

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 86.60  E-value: 3.38e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1258 VYQIKLPERDrkKRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDN 1334
Cdd:cd11304      1 SYEVSVPENA--PPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLdreEQSSY-TLTVTATDG 77

                           90
                   ....*....|....
gi 1907198160 1335 GRPQKSSTARLHIE 1348
Cdd:cd11304     78 GGPPLSSTATVTIT 91
Cadherin pfam00028
Cadherin domain;
477-568 1.17e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.04  E-value: 1.17e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  477 YETFVNESVRVGTNVLTVSASDKDKGENGYITYSIASLNLLP-FAINQFTGVISTTEELDFEsSPETYRFIVRASDWGSP 555
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRE-SIGEYELTVEATDSGGP 79

                           90
                   ....*....|...
gi 1907198160  556 YRhESEVNVTIRV 568
Cdd:pfam00028   80 PL-SSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 855-934 4.94e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.78  E-value: 4.94e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   855 ARDKDLGSNGEVMYSVL--TDTHQFIINSSTGIVYIADQLDRESKANYSLKIEARDKAesGQQLFSVVTLKIFLDDVNDC 932
Cdd:smart00112    2 ATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVNDN 79


                    ..
gi 1907198160   933 SP 934
Cdd:smart00112   80 AP 81
Cadherin pfam00028
Cadherin domain;
836-924 5.46e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.12  E-value: 5.46e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  836 YSVSILESSSIGTEIIQVEARDKDLGSNGEVMYSVLTDT--HQFIINSSTGIVYIADQLDRESKANYSLKIEARDkaESG 913
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGpgGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD--SGG 78

                           90
                   ....*....|.
gi 1907198160  914 QQLFSVVTLKI 924
Cdd:pfam00028   79 PPLSSTATVTI 89
Cadherin pfam00028
Cadherin domain;
941-1018 1.70e-18

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 81.58  E-value: 1.70e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907198160  941 YSVKVLEDLPVGTVIAWLETQDPDLGLGGQVRYSLVNDYNGR-FEVDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79
Cadherin pfam00028
Cadherin domain;
733-822 6.88e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 76.96  E-value: 6.88e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  733 VAVKEDMLVGTNILKIKAYDADSGFNGKVLFTISDGNTDSCFNIDMETGQLKVLMPMDREHTDLYVLNITIYDLGKPQKS 812
Cdd:pfam00028    3 ASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPPLS 82

                           90
                   ....*....|
gi 1907198160  813 SWRLLTVNVE 822
Cdd:pfam00028   83 STATVTITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 380-468 8.93e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 76.97  E-value: 8.93e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  380 VYEVSISEFSPPGVLVAIVKV----SPEPLDVEYKLLPGKDSDYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGD-- 453
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSAtdpdSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGgp 80

                           90
                   ....*....|....*...
gi 1907198160  454 ---AKAQVTIGIEDANDH 468
Cdd:cd11304     81 plsSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
1259-1348 4.68e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 74.64  E-value: 4.68e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1259 YQIKLPERDRkkRGEPIYRAFAFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYdILTIKAVDNG 1335
Cdd:pfam00028    1 YSASVPENAP--VGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLdreSIGEY-ELTVEATDSG 77

                           90
                   ....*....|...
gi 1907198160 1336 RPQKSSTARLHIE 1348
Cdd:pfam00028   78 GPPLSSTATVTIT 90
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1280-1348 1.50e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 1.50e-15
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907198160  1280 AFDKDEGPNAEISYSIVDGNDDGKFFIDPKTGMVSSRKQF---TAGSYDiLTIKAVDNGRPQKSSTARLHIE 1348
Cdd:smart00112    2 ATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLdreEQPEYT-LTVEATDGGGPPLSSTATVTIT 72
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 181-264 1.54e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 72.77  E-value: 1.54e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   181 TATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRGMKlygnnGVSSTAKLYVHIER 258
Cdd:smart00112    1 SATDADSGENGKVTYSILsgNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-----PLSSTATVTITVLD 75


                    ....*.
gi 1907198160   259 INEHAP 264
Cdd:smart00112   76 VNDNAP 81
Cadherin pfam00028
Cadherin domain;
163-257 2.98e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 72.33  E-value: 2.98e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  163 YSVTIAESTPLRTSVAQVTATDADIGSNGEFYYYFK--NKVDLFSVHPTSGVISLSGRLNYDEKNRYDLEILAVDRgmkl 240
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILggGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS---- 76

                           90
                   ....*....|....*..
gi 1907198160  241 yGNNGVSSTAKLYVHIE 257
Cdd:pfam00028   77 -GGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 962-1018 4.28e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 4.28e-14
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907198160   962 DPDLGLGGQVRYSLV-NDYNGRFEVDKASGAIRLSKELDYEKQQFYNLTVRAKDKGRP 1018
Cdd:smart00112    4 DADSGENGKVTYSILsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP 61
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 395-470 1.55e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 58.52  E-value: 1.55e-10
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   395 VAIVKVSPEPLDVEYKLLPGKDSDYFKINPRSGLIVTAQPLNTVKKEVYKLEVSDKEGD-----AKAQVTIGIEDANDHT 469
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGgpplsSTATVTITVLDVNDNA 80


                    .
gi 1907198160   470 P 470
Cdd:smart00112   81 P 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 592-672 4.08e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.09  E-value: 4.08e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  592 PVGGHITAISAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSgiKNGNFALRITATDGEN--FADPMAI 667
Cdd:cd11304     11 PPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDRE--EQSSYTLTVTATDGGGppLSSTATV 88


                   ....*
gi 1907198160  668 NISVL 672
Cdd:cd11304     89 TITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 47-153 8.77e-09

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 54.24  E-value: 8.77e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   47 TYNATVYENSAARTYVnsqsrMGITLIDL----SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNR 119
Cdd:cd11304      1 SYEVSVPENAPPGTVV-----LTVSATDPdsgeNGEVTYSIVSGNEDGLF-------------SIDPSTGEittAKPLDR 62

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1907198160  120 EIQDNYLLIIKGSVRGED-LEAWTKVNIQVLDMND 153
Cdd:cd11304     63 EEQSSYTLTVTATDGGGPpLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 76-156 1.46e-06

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 47.34  E-value: 1.46e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160    76 SWDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQDNYLLIIKGSVRGED-LEAWTKVNIQVLDM 151
Cdd:smart00112   10 NGKVTYSILSGNDDGLF-------------SIDPETGEittTKPLDREEQPEYTLTVEATDGGGPpLSSTATVTITVLDV 76


                    ....*
gi 1907198160   152 NDLRP 156
Cdd:smart00112   77 NDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1367-1461 1.58e-06

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 47.69  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1367 YNFTVMESDKVTEIVGVVSVQ----PANTPLWFDIVGGkHAREMFYIlqtacgqncsteggnfDSSFdaekgvGTIVIAK 1442
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATdpdsGENGEVTYSIVSG-NEDGLFSI----------------DPST------GEITTAK 58

                           90
                   ....*....|....*....
gi 1907198160 1443 PLDAEQRSVYNMSVEVTDG 1461
Cdd:cd11304     59 PLDREEQSSYTLTVTATDG 77
Cadherin pfam00028
Cadherin domain;
381-463 1.78e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 47.68  E-value: 1.78e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  381 YEVSISEFSPPGVLVAIVKVSPEPLD----VEYKLLPGKDSDYFKINPRSGLIVTAQPLNTVKKEVYKLEV--SDKEGDA 454
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGpngrIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVeaTDSGGPP 80

                           90
                   ....*....|..
gi 1907198160  455 K---AQVTIGIE 463
Cdd:pfam00028   81 LsstATVTITVL 92
Cadherin pfam00028
Cadherin domain;
592-672 4.46e-06

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 46.52  E-value: 4.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  592 PVGGHITAISAIDIDE--LELVKYKIISGNELGFFYLNPDSGVLQLKKSLmnSGIKNGNFALRITATD--GENFADPMAI 667
Cdd:pfam00028   10 PVGTEVLTVTATDPDLgpNGRIFYSILGGGPGGNFRIDPDTGDISTTKPL--DRESIGEYELTVEATDsgGPPLSSTATV 87


                   ....*
gi 1907198160  668 NISVL 672
Cdd:pfam00028   88 TITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 286-373 1.23e-05

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 44.65  E-value: 1.23e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   286 TVDDLDEGANGEIeSLSIVDGDPLEQFFLAKEGKWlneykVKERRQVDWESFSYgYNLTIQAKDKGSPQKFSELkTVHI- 364
Cdd:smart00112    1 SATDADSGENGKV-TYSILSGNDDGLFSIDPETGE-----ITTTKPLDREEQPE-YTLTVEATDGGGPPLSSTA-TVTIt 72

                            90
                    ....*....|..
gi 1907198160   365 ---ANprrDNTP 373
Cdd:smart00112   73 vldVN---DNAP 81
Cadherin pfam00028
Cadherin domain;
1367-1461 5.13e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.44  E-value: 5.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1367 YNFTVMESDKVTEIVGVVSVQPANTPLwfdivggkHAREMFYILqtacgqncsteGGNFDSSFDAEKGVGTIVIAKPLDA 1446
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGP--------NGRIFYSIL-----------GGGPGGNFRIDPDTGDISTTKPLDR 61

                           90
                   ....*....|....*
gi 1907198160 1447 EQRSVYNMSVEVTDG 1461
Cdd:pfam00028   62 ESIGEYELTVEATDS 76
Cadherin pfam00028
Cadherin domain;
283-364 5.99e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 43.06  E-value: 5.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160  283 AVVTVDDLDEGANGEIeSLSIVDGDPLEQFFLAKEGKWLneykvKERRQVDWESFSYgYNLTIQAKDKGSPQKFSELkTV 362
Cdd:pfam00028   16 LTVTATDPDLGPNGRI-FYSILGGGPGGNFRIDPDTGDI-----STTKPLDRESIGE-YELTVEATDSGGPPLSSTA-TV 87


                   ..
gi 1907198160  363 HI 364
Cdd:pfam00028   88 TI 89
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 601-658 3.94e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 40.41  E-value: 3.94e-04
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   601 SAIDIDELE--LVKYKIISGNELGFFYLNPDSGVLQLKKSLMNSgiKNGNFALRITATDG 658
Cdd:smart00112    1 SATDADSGEngKVTYSILSGNDDGLFSIDPETGEITTTKPLDRE--EQPEYTLTVEATDG 58
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1050-1144 6.49e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.41  E-value: 6.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1050 GSVKENSRIGTSVLQV-TAHDEDSGRDGEIQYSIRDgSGLGRFNIDDESGVITAADSLDRETTASYWLTVYATDRGVVPL 1128
Cdd:cd00031      4 GSAVEGRSRGSFRVSIpTDLIASSGEIIKISAAGKE-ALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP 82

                           90
                   ....*....|....*.
gi 1907198160 1129 YSTIEVYIEVEDVNDN 1144
Cdd:cd00031     83 QTSSVFSIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1422-1461 9.71e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 39.26  E-value: 9.71e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1907198160  1422 GGNFDSSFDAEKGVGTIVIAKPLDAEQRSVYNMSVEVTDG 1461
Cdd:smart00112   19 SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDG 58
Cadherin_3 pfam16184
Cadherin-like;
1131-1194 1.50e-03

Cadherin-like;


Pssm-ID: 465048 [Multi-domain]  Cd Length: 111  Bit Score: 39.89  E-value: 1.50e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907198160 1131 TIEVYIEVEDVNDNAPL--TSEPIYypvVMENSPKDVSVIQIQAEDPDSgSNEKLTYRITSGnPQN 1194
Cdd:pfam16184    4 PFTFNITIIPVNDEAPVltTNTGLR---LWEGSSRPITPDLLQAEDPDT-PPEDLTYTVVQG-PSH 64
Cadherin pfam00028
Cadherin domain;
48-149 3.80e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 38.05  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160   48 YNATVYENSAARTYVNsqsRMGITLIDLS--WDIKYRIVSGDEEGFFkaeeviiadfcflRIRTKGGN---SAILNREIQ 122
Cdd:pfam00028    1 YSASVPENAPVGTEVL---TVTATDPDLGpnGRIFYSILGGGPGGNF-------------RIDPDTGDistTKPLDRESI 64

                           90       100
                   ....*....|....*....|....*...
gi 1907198160  123 DNYLLIIKGSVRGE-DLEAWTKVNIQVL 149
Cdd:pfam00028   65 GEYELTVEATDSGGpPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1157-1250 4.98e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 38.09  E-value: 4.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198160 1157 VMENSPKDVSVIQIQAedpDSGSNEKLTYRITS-GN--PQNFFAINIKTGLITTTsRKLDREQQAEHFLEVTVTDGGSSP 1233
Cdd:cd00031      6 AVEGRSRGSFRVSIPT---DLIASSGEIIKISAaGKeaLPSWLHWEPHSGILEGL-EKLDREDKGVHYISVSAASLGANV 81

                           90
                   ....*....|....*..
gi 1907198160 1234 KQSTIWVVVQVLDENDN 1250
Cdd:cd00031     82 PQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH