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Conserved domains on  [gi|1907198785|ref|XP_036010981|]
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glycerol-3-phosphate dehydrogenase 1-like protein isoform X1 [Mus musculus]

Protein Classification

glycerol-3-phosphate dehydrogenase family protein( domain architecture ID 11496765)

glycerol-3-phosphate dehydrogenase family protein is similar to human L-alpha-glycerol-3-phosphate dehydrogenase 1 (GPD1), which catalyzes the reversible biological conversion of dihydroxyacetone (DHAP) to glycerol-3-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 1-305 3.17e-168

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


:

Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 470.67  E-value: 3.17e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785   1 MWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLSEAVQDADLLVFVIPHQFIHKICDEITGRVPEKALGIT 80
Cdd:TIGR03376  35 MWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAAKGADILVFVIPHQFLEGICKQLKGHVKPNARAIS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  81 LIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAAEKFCETTIGSKVMQN----GLLFKELLQTPNFRITVVDD 156
Cdd:TIGR03376 115 CIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSETTVGYRDPADfdvdARVLKALFHRPYFRVNVVDD 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 157 ADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFAKIFCKGQVSTATFlESCGVADLITTCYGGRNRRV 236
Cdd:TIGR03376 195 VAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFARMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKV 273

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907198785 237 AEAFARTGKTIEELEKELLNGQKLQGPQTSAEVYRILRQKGLLDKFPLFTAVYQICYEGRPVTQMLSCL 305
Cdd:TIGR03376 274 GRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEFPLFEAVYQILYEGLPPKKLPECL 342
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 1-305 3.17e-168

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 470.67  E-value: 3.17e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785   1 MWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLSEAVQDADLLVFVIPHQFIHKICDEITGRVPEKALGIT 80
Cdd:TIGR03376  35 MWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAAKGADILVFVIPHQFLEGICKQLKGHVKPNARAIS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  81 LIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAAEKFCETTIGSKVMQN----GLLFKELLQTPNFRITVVDD 156
Cdd:TIGR03376 115 CIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSETTVGYRDPADfdvdARVLKALFHRPYFRVNVVDD 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 157 ADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFAKIFCKGQVSTATFlESCGVADLITTCYGGRNRRV 236
Cdd:TIGR03376 195 VAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFARMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKV 273

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907198785 237 AEAFARTGKTIEELEKELLNGQKLQGPQTSAEVYRILRQKGLLDKFPLFTAVYQICYEGRPVTQMLSCL 305
Cdd:TIGR03376 274 GRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEFPLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-297 3.34e-143

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 407.87  E-value: 3.34e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785   1 MWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLSEAVQDADLLVFVIPHQFIHKICDEI--TGRVPEKALG 78
Cdd:PTZ00345   46 MWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLKEAVEDADLLIFVIPHQFLESVLSQIkeNNNLKKHARA 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  79 ITLIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAAEKFCETTIGSKVMQNGLLFKELLQTPNFRITVVDDAD 158
Cdd:PTZ00345  126 ISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAREEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVI 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 159 TVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFAKIFCKgQVSTATFLESCGVADLITTCYGGRNRRVAE 238
Cdd:PTZ00345  206 GVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLFGKIFFP-NVMDETFFESCGLADLITTCLGGRNVRCAA 284

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907198785 239 AFARTG--KTIEELEKELLNGQKLQGPQTSAEVYRILRQKGLLDKFPLFTAVYQICYEGRP 297
Cdd:PTZ00345  285 EFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLKKEFPLFTVTYKIAFEGAD 345
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 17-309 3.38e-83

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 253.81  E-value: 3.38e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  17 INNDHENVKYLPGHKLPENVVAVPNLSEAVQDADLLVFVIPHQFIHKICDEITGRVPEKALGITLIKGIDegPDGLKLIS 96
Cdd:COG0240    39 INETRENPRYLPGVKLPENLRATSDLEEALAGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMS 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  97 DIIREKMGID--ISVLMGANIASEVAAEKFCETTIGSKVMQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGA 174
Cdd:COG0240   117 EVIAEELPGAlrIAVLSGPSFAEEVARGLPTAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAA 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 175 GFCDGLRCGDNTKAAVIRLGLMEMIAFAKIFckgQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEK 252
Cdd:COG0240   197 GIADGLGLGDNARAALITRGLAEMTRLGVAL---GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALA 272

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907198785 253 ELlnGQKLQGPQTSAEVYRILRQKGLldKFPLFTAVYQICYEGRPVTQMLSCLQSHP 309
Cdd:COG0240   273 EM--GMVAEGVYTAKAVYELAEKLGV--EMPITEAVYAVLYEGKSPREAVEALMARP 325
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 156-302 1.31e-63

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 197.23  E-value: 1.31e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 156 DADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFAKIFCKgqvSTATFLESCGVADLITTCYGG--RN 233
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGA---KPETFFGLAGLGDLIVTCTSGlsRN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907198785 234 RRVAEAFARtGKTIEELEKELlnGQKLQGPQTSAEVYRILRQKGLldKFPLFTAVYQICYEGRPVTQML 302
Cdd:pfam07479  78 RRFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
 
Name Accession Description Interval E-value
glycerol3P_DH TIGR03376
glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic ...
 1-305 3.17e-168

glycerol-3-phosphate dehydrogenase (NAD(+)); Members of this protein family are the eukaryotic enzyme, glycerol-3-phosphate dehydrogenase (NAD(+)) (EC 1.1.1.8). Enzymatic activity for 1.1.1.8 is defined as sn-glycerol 3-phosphate + NAD(+) = glycerone phosphate + NADH. Note the very similar reactions of enzymes defined as EC 1.1.1.94 and 1.1.99.5, assigned to families of proteins in the bacteria.


Pssm-ID: 274551 [Multi-domain]  Cd Length: 342  Bit Score: 470.67  E-value: 3.17e-168
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785   1 MWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLSEAVQDADLLVFVIPHQFIHKICDEITGRVPEKALGIT 80
Cdd:TIGR03376  35 MWVFEEEIEGRNLTEIINTTHENVKYLPGIKLPANLVAVPDLVEAAKGADILVFVIPHQFLEGICKQLKGHVKPNARAIS 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  81 LIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAAEKFCETTIGSKVMQN----GLLFKELLQTPNFRITVVDD 156
Cdd:TIGR03376 115 CIKGLEVSKDGVKLLSDIIEEELGIPCGVLSGANLANEVAKEKFSETTVGYRDPADfdvdARVLKALFHRPYFRVNVVDD 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 157 ADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFAKIFCKGQVSTATFlESCGVADLITTCYGGRNRRV 236
Cdd:TIGR03376 195 VAGVEIAGALKNVVAIAAGFVDGLGWGDNAKAAVMRRGLLEMIKFARMFFPTGEVTFTF-ESCGVADLITTCLGGRNFKV 273

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907198785 237 AEAFARTGKTIEELEKELLNGQKLQGPQTSAEVYRILRQKGLLDKFPLFTAVYQICYEGRPVTQMLSCL 305
Cdd:TIGR03376 274 GRAFAKTGKSLEELEKELLNGQSLQGVATAKEVHELLKNKNKDDEFPLFEAVYQILYEGLPPKKLPECL 342
PTZ00345 PTZ00345
glycerol-3-phosphate dehydrogenase; Provisional
 1-297 3.34e-143

glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 240373 [Multi-domain]  Cd Length: 365  Bit Score: 407.87  E-value: 3.34e-143
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785   1 MWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAVPNLSEAVQDADLLVFVIPHQFIHKICDEI--TGRVPEKALG 78
Cdd:PTZ00345   46 MWVLEEIVEGEKLSDIINTKHENVKYLPGIKLPDNIVAVSDLKEAVEDADLLIFVIPHQFLESVLSQIkeNNNLKKHARA 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  79 ITLIKGIDEGPDGLKLISDIIREKMGIDISVLMGANIASEVAAEKFCETTIGSKVMQNGLLFKELLQTPNFRITVVDDAD 158
Cdd:PTZ00345  126 ISLTKGIIVENGKPVLCSDVIEEELGIPCCALSGANVANDVAREEFSEATIGCEDKDDALIWQRLFDRPYFKINCVPDVI 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 159 TVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFAKIFCKgQVSTATFLESCGVADLITTCYGGRNRRVAE 238
Cdd:PTZ00345  206 GVEVCGALKNIIALAAGFCDGLGLGTNTKSAIIRIGLEEMKLFGKIFFP-NVMDETFFESCGLADLITTCLGGRNVRCAA 284

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907198785 239 AFARTG--KTIEELEKELLNGQKLQGPQTSAEVYRILRQKGLLDKFPLFTAVYQICYEGRP 297
Cdd:PTZ00345  285 EFAKRNgkKSWEEIEAELLNGQKLQGTVTLKEVYEVLESHDLKKEFPLFTVTYKIAFEGAD 345
GpsA COG0240
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 17-309 3.38e-83

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440010 [Multi-domain]  Cd Length: 327  Bit Score: 253.81  E-value: 3.38e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  17 INNDHENVKYLPGHKLPENVVAVPNLSEAVQDADLLVFVIPHQFIHKICDEITGRVPEKALGITLIKGIDegPDGLKLIS 96
Cdd:COG0240    39 INETRENPRYLPGVKLPENLRATSDLEEALAGADLVLLAVPSQALREVLEQLAPLLPPGAPVVSATKGIE--PGTGLLMS 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  97 DIIREKMGID--ISVLMGANIASEVAAEKFCETTIGSKVMQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGA 174
Cdd:COG0240   117 EVIAEELPGAlrIAVLSGPSFAEEVARGLPTAVVVASEDEEVAERLQELLSTPYFRVYTSDDVIGVELGGALKNVIAIAA 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 175 GFCDGLRCGDNTKAAVIRLGLMEMIAFAKIFckgQVSTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEK 252
Cdd:COG0240   197 GIADGLGLGDNARAALITRGLAEMTRLGVAL---GARPETFMGLAGLGDLVLTCTSdlSRNRRFGLALGK-GKSLEEALA 272

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1907198785 253 ELlnGQKLQGPQTSAEVYRILRQKGLldKFPLFTAVYQICYEGRPVTQMLSCLQSHP 309
Cdd:COG0240   273 EM--GMVAEGVYTAKAVYELAEKLGV--EMPITEAVYAVLYEGKSPREAVEALMARP 325
gpsA PRK00094
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;
17-305 2.78e-74

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase;


Pssm-ID: 234629 [Multi-domain]  Cd Length: 325  Bit Score: 231.11  E-value: 2.78e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  17 INNDHENVKYLPGHKLPENVVAVPNLSEAVQDADLLVFVIPHQFIHKICDEITGRVPEKALGITLIKGIDEGPdgLKLIS 96
Cdd:PRK00094   40 INADRENPRYLPGIKLPDNLRATTDLAEALADADLILVAVPSQALREVLKQLKPLLPPDAPIVWATKGIEPGT--GKLLS 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  97 DIIREKMG--IDISVLMGANIASEVAAEKFCETTIGSKVMQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGA 174
Cdd:PRK00094  118 EVLEEELPdlAPIAVLSGPSFAKEVARGLPTAVVIASTDEELAERVQELFHSPYFRVYTNTDVIGVELGGALKNVIAIAA 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 175 GFCDGLRCGDNTKAAVIRLGLMEMIAFAKIF-CKgqvsTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELE 251
Cdd:PRK00094  198 GIADGLGLGDNARAALITRGLAEITRLGVALgAN----PETFLGLAGLGDLVLTCTSplSRNRRFGLALGQ-GKSLEEAL 272

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907198785 252 KELlnGQKLQGPQTSAEVYRILRQKGLldKFPLFTAVYQICYEGRPVTQMLSCL 305
Cdd:PRK00094  273 AEI--GMVAEGVRTAKAVYELAKKLGV--EMPITEAVYAVLYEGKDPREAVEDL 322
NAD_Gly3P_dh_C pfam07479
NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent ...
 156-302 1.31e-63

NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain.


Pssm-ID: 462178 [Multi-domain]  Cd Length: 142  Bit Score: 197.23  E-value: 1.31e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 156 DADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFAKIFCKgqvSTATFLESCGVADLITTCYGG--RN 233
Cdd:pfam07479   1 DVIGVELGGALKNVIAIAAGIADGLGLGDNAKAALITRGLAEMIRLGKALGA---KPETFFGLAGLGDLIVTCTSGlsRN 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907198785 234 RRVAEAFARtGKTIEELEKELlnGQKLQGPQTSAEVYRILRQKGLldKFPLFTAVYQICYEGRPVTQML 302
Cdd:pfam07479  78 RRFGEALGK-GKSLEEAEKEL--GQVAEGVYTAKAVYELAKKLGV--EMPIFEAVYRILYEGKSPEEAL 141
NAD_Gly3P_dh_N pfam01210
NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent ...
 1-136 1.56e-48

NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyzes the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain.


Pssm-ID: 395967 [Multi-domain]  Cd Length: 158  Bit Score: 159.28  E-value: 1.56e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785   1 MWVFEEtvngrKLTDIINNDHENVKYLPGHKLPENVVAVPNLSEAVQDADLLVFVIPHQFIHKICDEITGRVPEKALGIT 80
Cdd:pfam01210  27 LWGRDE-----ELIEEINTTHENVRYLPGIKLPENLKATTDLAEALKGADIIVIVVPSQALREVLKQLKGLLKPDAILVS 101

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1907198785  81 LIKGIDEGpdGLKLISDIIREKMGI--DISVLMGANIASEVAAEKFCETTIGSKVMQN 136
Cdd:pfam01210 102 LSKGIEPG--TLKLLSEVIEEELGIqpPIAVLSGPSHAEEVAQGLPTATVIASKDEEA 157
PRK12439 PRK12439
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 1-278 7.54e-38

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 171500 [Multi-domain]  Cd Length: 341  Bit Score: 137.22  E-value: 7.54e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785   1 MWV-FEETVNGrkltdiINNDHENVKYLP-GHKLPENVVAVPNLSEAVQDADLLVFVIP-HQF---IHKICDEITGRVPE 74
Cdd:PRK12439   34 QWVrSAETADD------INDNHRNSRYLGnDVVLSDTLRATTDFAEAANCADVVVMGVPsHGFrgvLTELAKELRPWVPV 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  75 kalgITLIKGIDEGPDglKLISDIIREKM-GIDISVLMGANIASEVAAEKFCETTIGskvMQNGLL---FKELLQTPNFR 150
Cdd:PRK12439  108 ----VSLVKGLEQGTN--MRMSQIIEEVLpGHPAGILAGPNIAREVAEGYAAAAVLA---MPDQHLatrLSPLFRTRRFR 178

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 151 ITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMiafAKIFCKGQVSTATFLESCGVADLITTCYG 230
Cdd:PRK12439  179 VYTTDDVVGVEMAGALKNVFAIAVGMGYSLGIGENTRAMVIARALREM---TKLGVAMGGNPETFAGLAGMGDLIVTCTS 255

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1907198785 231 --GRNRRVAEAFARtGKTIEELEKELlnGQKLQGPQTSAEVYRILRQKGL 278
Cdd:PRK12439  256 qrSRNRHVGEQLGA-GKPIDEIIASM--NQVAEGVKAASVVMEFADEYGL 302
PRK14618 PRK14618
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 22-295 2.51e-37

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237770 [Multi-domain]  Cd Length: 328  Bit Score: 135.38  E-value: 2.51e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  22 ENVKYLPGHKLPENVVAVPNLSEAVQDADLLVFVIPHqfihKICDEITGRVPeKALGITL-IKGIDEGPDGLKLISDIIR 100
Cdd:PRK14618   48 ENREYLPGVALPAELYPTADPEEALAGADFAVVAVPS----KALRETLAGLP-RALGYVScAKGLAPDGGRLSELARVLE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 101 EKMGIDISVLMGANIASEVAAEKFCETTIGSKVMQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGL 180
Cdd:PRK14618  123 FLTQARVAVLSGPNHAEEIARFLPAATVVASPEPGLARRVQAAFSGPSFRVYTSRDRVGVELGGALKNVIALAAGMVDGL 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 181 RCGDNTKAAVIRLGLMEMIAFAKIFCKGQvstATFLESCGVADLITTCYG--GRNRRVAEAFARtgktieelekellnGQ 258
Cdd:PRK14618  203 KLGDNAKAALITRGLREMVRFGVALGAEE---ATFYGLSGLGDLIATATSphSRNRAAGEAIVR--------------GV 265

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1907198785 259 KLQGPQTSAEVYRILRQKGLLDKF--------PLFTAVYQICYEG 295
Cdd:PRK14618  266 DREHLEAGGKVVEGLYTVKALDAWakahghdlPIVEAVARVARGG 310
PRK14620 PRK14620
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 10-307 9.32e-26

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 173083 [Multi-domain]  Cd Length: 326  Bit Score: 104.53  E-value: 9.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  10 GRKLTDI--INNDHENVKYLPGHKLPENVVAVPNLSEAVQD-ADLLVFVIPHQFIHKICDEITGRVPEKALGITLI-KGI 85
Cdd:PRK14620   30 GRNHTTFesINTKRKNLKYLPTCHLPDNISVKSAIDEVLSDnATCIILAVPTQQLRTICQQLQDCHLKKNTPILICsKGI 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  86 DEgpDGLKLISDIIREKMGID-ISVLMGANIASEVAAEKFCETTIGSKVMQNGLLFKELLQTPNFRITVVDDADTVELCG 164
Cdd:PRK14620  110 EK--SSLKFPSEIVNEILPNNpIAILSGPSFAKEIAEKLPCSIVLAGQNETLGSSLISKLSNENLKIIYSQDIIGVQIGA 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 165 ALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAF--AKifcKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFAr 242
Cdd:PRK14620  188 ALKNIIAIACGIVLGKNLGNNAHAAVITKGMNEIKTLysAK---NGSIDLNTLIGPSCLGDLILTCTTLHSRNMSFGFK- 263

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907198785 243 TGKTiEELEKELLNGQKL-QGPQTSAEVYRIlrQKGLLDKFPLFTAVYQICYEGRPVTQMLSCLQS 307
Cdd:PRK14620  264 IGNG-FNINQILSEGKSViEGFSTVKPLISL--AKKLNIELPICESIYNLLYENISLEKTISVILS 326
PRK14619 PRK14619
NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional
 40-305 4.93e-25

NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional


Pssm-ID: 237771 [Multi-domain]  Cd Length: 308  Bit Score: 101.99  E-value: 4.93e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785  40 PNLSEAVQDADLLVFVIPHQFIHKICDEITG-RVPEKALGITLIKGIDegPDGLKLISDIIREKMGI-DISVLMGANIAS 117
Cdd:PRK14619   39 LSLAAVLADADVIVSAVSMKGVRPVAEQVQAlNLPPETIIVTATKGLD--PETTRTPSQIWQAAFPNhPVVVLSGPNLSK 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 118 EVAAEKFCETTIGSKVMQNGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLME 197
Cdd:PRK14619  117 EIQQGLPAATVVASRDLAAAETVQQIFSSERFRVYTNSDPLGTELGGTLKNVIAIAAGVCDGLQLGTNAKAALVTRALPE 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907198785 198 MIAFAKIFcKGQvsTATFLESCGVADLITTCYG--GRNRRVAEAFARtGKTIEELEKELlnGQKLQGPQTSAEVYRILRQ 275
Cdd:PRK14619  197 MIRVGTHL-GAQ--TETFYGLSGLGDLLATCTSplSRNYQVGYGLAQ-GKSLEQILAEL--EGTAEGVNTANVLVQLAQQ 270

                         250       260       270
                  ....*....|....*....|....*....|
gi 1907198785 276 KGLldKFPLFTAVYQICYEGRPVTQMLSCL 305
Cdd:PRK14619  271 QNI--AVPITEQVYRLLQGEITPQQALEEL 298
GPD_NAD_C_bact pfam20618
Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent ...
 219-288 5.62e-07

Bacterial GPD, NAD-dependent C-terminal; This is the C-terminal domain of NAD-dependent glycerol-3-phosphate dehydrogenase (GPD) from bacteria and archaea. GPD catalyzes the reversible reduction of dihydroxyacetone phosphate to glycerol-3-phosphate.


Pssm-ID: 466767 [Multi-domain]  Cd Length: 66  Bit Score: 45.95  E-value: 5.62e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907198785 219 CGVADLITTCYGG--RNRRVAEAFARtGKTIEELEkellNGQKLQGPQTSAEVYRILRQKGLLDkFPLFTAV 288
Cdd:pfam20618   1 AGLGDLVLTCTSDlsRNRTFGLLLGK-GMTLAEAG----NGQVAEGVRTAKAVAAILARAHNVE-MPILEAV 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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