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Conserved domains on  [gi|1907074584|ref|XP_036011635|]
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uncharacterized protein LOC216177 isoform X1 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-477 6.81e-14

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 6.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 140 KPYDCNECGKAFTCSSNLLLHKRTHTGEKPYDCSD--CGKAFASSSNLQIHKRKHTGEKPYGCNQCGKAFAYSNALQKHE 217
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 218 RSH-TREKIYECNQCGKAFARHRSLQNHEEHHTLEKPYECSQCGKAFA----------------------YSSNLYIHER 274
Cdd:COG5048   112 SSSsNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 275 SHTGEKPFKCTQCGKAFPSHSSLQIHERTHTGEKPYDCNECGKAFACRSNLLLHKRTHTGEKPYHCIECGKAFACSSSLQ 354
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 355 KHEKTHTGE-------KPYECNQCGKAFARRSDLYIHER--IHTGE--KPYEC--NQCGKAFVHCISLQRHERTHTGEKP 421
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907074584 422 YEC--NQCGKAFT-----RRFSLQVHERSHSGEKPYEC--NQCGKAFASRSSLRYHRKHHTAKKP 477
Cdd:COG5048   352 AKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-477 6.81e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 6.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 140 KPYDCNECGKAFTCSSNLLLHKRTHTGEKPYDCSD--CGKAFASSSNLQIHKRKHTGEKPYGCNQCGKAFAYSNALQKHE 217
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 218 RSH-TREKIYECNQCGKAFARHRSLQNHEEHHTLEKPYECSQCGKAFA----------------------YSSNLYIHER 274
Cdd:COG5048   112 SSSsNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 275 SHTGEKPFKCTQCGKAFPSHSSLQIHERTHTGEKPYDCNECGKAFACRSNLLLHKRTHTGEKPYHCIECGKAFACSSSLQ 354
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 355 KHEKTHTGE-------KPYECNQCGKAFARRSDLYIHER--IHTGE--KPYEC--NQCGKAFVHCISLQRHERTHTGEKP 421
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907074584 422 YEC--NQCGKAFT-----RRFSLQVHERSHSGEKPYEC--NQCGKAFASRSSLRYHRKHHTAKKP 477
Cdd:COG5048   352 AKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-433 1.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.85e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907074584 408 SLQRHERTHTGEKPYECNQCGKAFTR 433
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
140-477 6.81e-14

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 6.81e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 140 KPYDCNECGKAFTCSSNLLLHKRTHTGEKPYDCSD--CGKAFASSSNLQIHKRKHTGEKPYGCNQCGKAFAYSNALQKHE 217
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 218 RSH-TREKIYECNQCGKAFARHRSLQNHEEHHTLEKPYECSQCGKAFA----------------------YSSNLYIHER 274
Cdd:COG5048   112 SSSsNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntpqsnslhpplpanslskdpsSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 275 SHTGEKPFKCTQCGKAFPSHSSLQIHERTHTGEKPYDCNECGKAFACRSNLLLHKRTHTGEKPYHCIECGKAFACSSSLQ 354
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 355 KHEKTHTGE-------KPYECNQCGKAFARRSDLYIHER--IHTGE--KPYEC--NQCGKAFVHCISLQRHERTHTGEKP 421
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907074584 422 YEC--NQCGKAFT-----RRFSLQVHERSHSGEKPYEC--NQCGKAFASRSSLRYHRKHHTAKKP 477
Cdd:COG5048   352 AKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRP 416
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 418-473 1.53e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 1.53e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907074584 418 GEKPYECN--QCGKAFTRRFSLQVH---------------ERSHSG----EKPYECNQCGKAFASRSSLRYHRKHHT 473
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHmlhghqnqklhenpsPEKMNIfsakDKPYRCEVCDKRYKNLNGLKYHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
114-323 1.87e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 1.87e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 114 YECNHCGKSFPSRNSLQIHNRTHTG-EKPYDCNECGKAFTCSSNLLLHKRT--HTGE--KPYDC--SDCGKAFASSSNLQ 186
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 187 IHKRKHTGEKPYGCNqcgkafaysnaLQKHERSHTREKIYEcnqcgkafarHRSLQNHEEHHTLEKPYEC--SQCGKAFA 264
Cdd:COG5048   341 RHILLHTSISPAKEK-----------LLNSSSKFSPLLNNE----------PPQSLQQYKDLKNDKKSETlsNSCIRNFK 399

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907074584 265 YSSNLYIHERSHTGEKP--FKCTQCGKAFPSHSSLQIHERTHTGEKPYDCNECGKAFACRS 323
Cdd:COG5048   400 RDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
84-469 1.69e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584  84 KPYECKQCSQIFTNFCHLRKHEKKHTKEKLYECNH--CGKSFPSRNSLQIHNRTHTGEKPYDCN--ECGKAFTCSSNLLL 159
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSksLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 160 HKRTHTgEKPYDCSDCGKAFAS--------SSNLQIHKRKHTGEKPYGCN---------------QCGKAFAYSNALQKH 216
Cdd:COG5048   112 SSSSNS-NDNNLLSSHSLPPSSrdpqlpdlLSISNLRNNPLPGNNSSSVNtpqsnslhpplpansLSKDPSSNLSLLISS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 217 ERSHTREKIYECNQCGKAFARHRSLQNHEEHHTLEkPYECSQCGKAFAYSSNLYIHERSHTGEKPFKCTQCG------KA 290
Cdd:COG5048   191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptAS 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 291 FPSHSSLQIHERTHTG-EKPYDCNECGKAFACRSNLLLHKRT--HTGE--KPYHC--IECGKAFACSSSLQKHEKTHTGE 363
Cdd:COG5048   270 SQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907074584 364 KPYEC--NQCGKAF------ARRSDLYIHERIHTgEKPYEC--NQCGKAFVHCISLQRHERTHTGEKPYECN--QCGKAF 431
Cdd:COG5048   350 SPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1907074584 432 TRRFSLQVHERSHSGEKPYECNQCGKAFASRSSLRYHR 469
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-433 1.85e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.85e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907074584 408 SLQRHERTHTGEKPYECNQCGKAFTR 433
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
352-377 7.32e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.32e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907074584 352 SLQKHEKTHTGEKPYECNQCGKAFAR 377
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
324-349 8.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.91e-04
                          10        20
                  ....*....|....*....|....*.
gi 1907074584 324 NLLLHKRTHTGEKPYHCIECGKAFAC 349
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
436-461 2.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.92e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907074584 436 SLQVHERSHSGEKPYECNQCGKAFAS 461
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
296-321 3.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907074584 296 SLQIHERTHTGEKPYDCNECGKAFAC 321
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-291 3.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.29e-03
                          10        20
                  ....*....|....*....|....
gi 1907074584 268 NLYIHERSHTGEKPFKCTQCGKAF 291
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
380-405 3.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.32e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907074584 380 DLYIHERIHTGEKPYECNQCGKAFVH 405
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
156-181 5.87e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.87e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907074584 156 NLLLHKRTHTGEKPYDCSDCGKAFAS 181
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
128-153 8.36e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.36e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907074584 128 SLQIHNRTHTGEKPYDCNECGKAFTC 153
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
184-209 9.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.14e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907074584 184 NLQIHKRKHTGEKPYGCNQCGKAFAY 209
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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