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Conserved domains on  [gi|1907079384|ref|XP_036012063|]
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sperm-egg fusion protein TMEM95 isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM95 super family cl21068
TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are ...
 17-111 6.81e-54

TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are typically between 102 and 231 amino acids in length and they have a conserved LGG sequence motif. TMEM95 is a sperm membrane protein required for sperm-oocyte fusion and is essential for mammalian fertilization.


The actual alignment was detected with superfamily member pfam15203:

Pssm-ID: 464560  Cd Length: 151  Bit Score: 165.34  E-value: 6.81e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079384  17 CIFCRLQDHALANRLAQLNNQTKPKWKwkEW-ASPDFSAFALDEVSMKQVTEKTHRVLRVIEKKGSTSLIPLYWQWLQKT 95
Cdd:pfam15203   1 CVFCRLPAHDLSGRLAQLCSQMEAQWK--ECeASWDFSAFALDEVSMNKITEKTHRVLRVIEIKRSLSSLPLYWQWLQKT 78

                          90
                  ....*....|....*.
gi 1907079384  96 RIPQYTREALCAPVCR 111
Cdd:pfam15203  79 KLPEYTREALCAPACR 94
 
Name Accession Description Interval E-value
TMEM95 pfam15203
TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are ...
 17-111 6.81e-54

TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are typically between 102 and 231 amino acids in length and they have a conserved LGG sequence motif. TMEM95 is a sperm membrane protein required for sperm-oocyte fusion and is essential for mammalian fertilization.


Pssm-ID: 464560  Cd Length: 151  Bit Score: 165.34  E-value: 6.81e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079384  17 CIFCRLQDHALANRLAQLNNQTKPKWKwkEW-ASPDFSAFALDEVSMKQVTEKTHRVLRVIEKKGSTSLIPLYWQWLQKT 95
Cdd:pfam15203   1 CVFCRLPAHDLSGRLAQLCSQMEAQWK--ECeASWDFSAFALDEVSMNKITEKTHRVLRVIEIKRSLSSLPLYWQWLQKT 78

                          90
                  ....*....|....*.
gi 1907079384  96 RIPQYTREALCAPVCR 111
Cdd:pfam15203  79 KLPEYTREALCAPACR 94
 
Name Accession Description Interval E-value
TMEM95 pfam15203
TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are ...
 17-111 6.81e-54

TMEM95 family; TMEM95 and its homologs can be found in eukaryotes. Proteins in this family are typically between 102 and 231 amino acids in length and they have a conserved LGG sequence motif. TMEM95 is a sperm membrane protein required for sperm-oocyte fusion and is essential for mammalian fertilization.


Pssm-ID: 464560  Cd Length: 151  Bit Score: 165.34  E-value: 6.81e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907079384  17 CIFCRLQDHALANRLAQLNNQTKPKWKwkEW-ASPDFSAFALDEVSMKQVTEKTHRVLRVIEKKGSTSLIPLYWQWLQKT 95
Cdd:pfam15203   1 CVFCRLPAHDLSGRLAQLCSQMEAQWK--ECeASWDFSAFALDEVSMNKITEKTHRVLRVIEIKRSLSSLPLYWQWLQKT 78

                          90
                  ....*....|....*.
gi 1907079384  96 RIPQYTREALCAPVCR 111
Cdd:pfam15203  79 KLPEYTREALCAPACR 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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