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Conserved domains on  [gi|1907081572|ref|XP_036012540|]
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zinc finger protein 62 isoform X2 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
430-843 4.71e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 4.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 430 RPYVCDVCGKTFRNNSGLKVHRRLHTGEKPYKCDV--CGKAYISRSSLKNHKGIHMGEKPYKCSYCEKSFNYSSALEQHK 507
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 508 R-IHTREKPFGCDECGKAFRNNSGLKVHKRIHTGERPYKCEEC------GKAYISLSSLINHKSVHPGEKPFKCDECEKA 580
Cdd:COG5048   112 SsSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvnTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 581 FITyrTLLNHKKIHLGEKPYKCDVC---EKSFNYTSLLSQHKRVHTREKPFecDRCEKVFRNNSSLKVHKRIHtgekpYE 657
Cdd:COG5048   192 VST--SIPSSSENSPLSSSYSIPSSssdQNLENSSSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASES-----PR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 658 CDICGKAYISHSSLINHKSTHPGKT-SYTCDECGKAFFSSRTLISHKR--VHLGE--KPFKCVE--CGKSFSYSSLLSQH 730
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 731 KRIHTGEKPYVCDWC-------GKAFRNSSGLTVHKRIHTGEKPYGCD--ECEKAYISHSSLINHKSVHRGKQPYNCE-- 799
Cdd:COG5048   343 ILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1907081572 800 -CGKSFNYRSVLDQHKRIHTGKKPYRCNDCGKaFNIRSNLTKHKR 843
Cdd:COG5048   423 pCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 372-451 5.55e-09

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 59.35  E-value: 5.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 372 GEKPYKCDI--CGKAFSYSSGLAVHK-SIHPGKKAHECKDCGKsfsynslllqHKTIHTGERPYVCDVCGKTFRNNSGLK 448
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1907081572 449 VHR 451
Cdd:COG5189   416 YHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-535 2.34e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 120 DKKLHKCDECGKSFKYNSRLVQHKIMHTGEKRYEC--DDCRGTFRSSSSLRVHKRIHTGEKPYKCDECGKAYMSY--SSL 195
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKasSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 196 INHKSTHS--GEKNCKCDECGKSFNYSSVLDQHKRIHTGEKPYECGECGKAFRNSSGLRVHKRIHtgekpyecdTCGKTF 273
Cdd:COG5048   110 LSSSSSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---------SLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 274 SNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSIHFGDKPYKCDECEKSFNYSSLLIQHKVIHTGEKPYECDEC 353
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 354 GKAFRNSSGLIVHKRIHTGE-------KPYKCDICGKAFSYSSGLAVHK--SIHPGK--KAHEC--KDCGKSFSYNSLLL 420
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 421 QHKTIHTGERPYVCDVCGKTFRNNSGLK-------VHRRLHTGEKPYKCDV--CGKAYISRSSLKNHKGIHMGEKP--YK 489
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1907081572 490 CSYCEKSFNYSSALEQHKRIHTREKPFGCDECGKAFRNNSGLKVHK 535
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
430-843 4.71e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 4.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 430 RPYVCDVCGKTFRNNSGLKVHRRLHTGEKPYKCDV--CGKAYISRSSLKNHKGIHMGEKPYKCSYCEKSFNYSSALEQHK 507
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 508 R-IHTREKPFGCDECGKAFRNNSGLKVHKRIHTGERPYKCEEC------GKAYISLSSLINHKSVHPGEKPFKCDECEKA 580
Cdd:COG5048   112 SsSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvnTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 581 FITyrTLLNHKKIHLGEKPYKCDVC---EKSFNYTSLLSQHKRVHTREKPFecDRCEKVFRNNSSLKVHKRIHtgekpYE 657
Cdd:COG5048   192 VST--SIPSSSENSPLSSSYSIPSSssdQNLENSSSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASES-----PR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 658 CDICGKAYISHSSLINHKSTHPGKT-SYTCDECGKAFFSSRTLISHKR--VHLGE--KPFKCVE--CGKSFSYSSLLSQH 730
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 731 KRIHTGEKPYVCDWC-------GKAFRNSSGLTVHKRIHTGEKPYGCD--ECEKAYISHSSLINHKSVHRGKQPYNCE-- 799
Cdd:COG5048   343 ILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1907081572 800 -CGKSFNYRSVLDQHKRIHTGKKPYRCNDCGKaFNIRSNLTKHKR 843
Cdd:COG5048   423 pCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 372-451 5.55e-09

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 59.35  E-value: 5.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 372 GEKPYKCDI--CGKAFSYSSGLAVHK-SIHPGKKAHECKDCGKsfsynslllqHKTIHTGERPYVCDVCGKTFRNNSGLK 448
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1907081572 449 VHR 451
Cdd:COG5189   416 YHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-535 2.34e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 120 DKKLHKCDECGKSFKYNSRLVQHKIMHTGEKRYEC--DDCRGTFRSSSSLRVHKRIHTGEKPYKCDECGKAYMSY--SSL 195
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKasSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 196 INHKSTHS--GEKNCKCDECGKSFNYSSVLDQHKRIHTGEKPYECGECGKAFRNSSGLRVHKRIHtgekpyecdTCGKTF 273
Cdd:COG5048   110 LSSSSSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---------SLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 274 SNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSIHFGDKPYKCDECEKSFNYSSLLIQHKVIHTGEKPYECDEC 353
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 354 GKAFRNSSGLIVHKRIHTGE-------KPYKCDICGKAFSYSSGLAVHK--SIHPGK--KAHEC--KDCGKSFSYNSLLL 420
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 421 QHKTIHTGERPYVCDVCGKTFRNNSGLK-------VHRRLHTGEKPYKCDV--CGKAYISRSSLKNHKGIHMGEKP--YK 489
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1907081572 490 CSYCEKSFNYSSALEQHKRIHTREKPFGCDECGKAFRNNSGLKVHK 535
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 486-534 3.83e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.85  E-value: 3.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907081572 486 KPYkCSYCEKSFNYSSALEQHKRIHTrekpFGCDECGKAFRNNSGLKVH 534
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-303 3.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.91e-04
                          10        20
                  ....*....|....*....|....*
gi 1907081572 279 LRVHKRIHTGEKPYECDECGKAFIT 303
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-387 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....*
gi 1907081572 363 LIVHKRIHTGEKPYKCDICGKAFSY 387
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
810-833 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 1907081572 810 LDQHKRIHTGKKPYRCNDCGKAFN 833
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 346-394 2.34e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 2.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907081572 346 KPYeCDECGKAFRNSSGLIVHKRIHTgekpYKCDICGKAFSYSSGLAVH 394
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
430-843 4.71e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 66.26  E-value: 4.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 430 RPYVCDVCGKTFRNNSGLKVHRRLHTGEKPYKCDV--CGKAYISRSSLKNHKGIHMGEKPYKCSYCEKSFNYSSALEQHK 507
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 508 R-IHTREKPFGCDECGKAFRNNSGLKVHKRIHTGERPYKCEEC------GKAYISLSSLINHKSVHPGEKPFKCDECEKA 580
Cdd:COG5048   112 SsSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvnTPQSNSLHPPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 581 FITyrTLLNHKKIHLGEKPYKCDVC---EKSFNYTSLLSQHKRVHTREKPFecDRCEKVFRNNSSLKVHKRIHtgekpYE 657
Cdd:COG5048   192 VST--SIPSSSENSPLSSSYSIPSSssdQNLENSSSSLPLTTNSQLSPKSL--LSQSPSSLSSSDSSSSASES-----PR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 658 CDICGKAYISHSSLINHKSTHPGKT-SYTCDECGKAFFSSRTLISHKR--VHLGE--KPFKCVE--CGKSFSYSSLLSQH 730
Cdd:COG5048   263 SSLPTASSQSSSPNESDSSSEKGFSlPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 731 KRIHTGEKPYVCDWC-------GKAFRNSSGLTVHKRIHTGEKPYGCD--ECEKAYISHSSLINHKSVHRGKQPYNCE-- 799
Cdd:COG5048   343 ILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*
gi 1907081572 800 -CGKSFNYRSVLDQHKRIHTGKKPYRCNDCGKaFNIRSNLTKHKR 843
Cdd:COG5048   423 pCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
317-759 4.74e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.79  E-value: 4.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 317 DKPYKCDECEKSFNYSSLLIQHKVIHTGEKPYEC--DECGKAFRNSSGLIVHKRIHTGEKPYKCDICGKafSYSSGLAVH 394
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 395 KSIHpgkkaheckdCGKSFSYNSLLLQHKTIHTGERPYVCDVCGKTFRNNSGLKVHRRLHTgekpyKCDVCGKAYISRSS 474
Cdd:COG5048   109 SLSS----------SSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV-----NTPQSNSLHPPLPA 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 475 LKNHKGIHMGEKPYKCSycEKSFNYSSALEQHKRIHTREKPFGCDECGKaFRNNSGLKVHKRIHTGERPYKCEecgkayi 554
Cdd:COG5048   174 NSLSKDPSSNLSLLISS--NVSTSIPSSSENSPLSSSYSIPSSSSDQNL-ENSSSSLPLTTNSQLSPKSLLSQ------- 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 555 slssliNHKSVHPGEKPFKCDECEKAFITYRTLLNHKKIHLGE-------KPYKCDVCEKSFNYTSLLSQHKR--VHTRE 625
Cdd:COG5048   244 ------SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 626 --KPFECD--RCEKVFRNNSSLKVHKRIHTGEKPYECDIC--------GKAYISHSSLINHKSTHPGKTSYTCDECGKAF 693
Cdd:COG5048   318 slKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfspLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRN 397

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907081572 694 FSSR-TLISHKRVHLGEKP--FKCVECGKSFSYSSLLSQHKRIHTGEKPYVCDWCGKAFRNSSGLTVHK 759
Cdd:COG5048   398 FKRDsNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 372-451 5.55e-09

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 59.35  E-value: 5.55e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 372 GEKPYKCDI--CGKAFSYSSGLAVHK-SIHPGKKAHECKDCGKsfsynslllqHKTIHTGERPYVCDVCGKTFRNNSGLK 448
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1907081572 449 VHR 451
Cdd:COG5189   416 YHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 451-535 2.06e-08

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 57.42  E-value: 2.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 451 RRLHT-GEKPYKCDV--CGKAYISRSSLKNHKgihmgekpyKCSYCEKSFNYSSALEQHKRIHTREKPFGCDECGKAFRN 527
Cdd:COG5189   340 RMLKVkDGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKN 410


                  ....*...
gi 1907081572 528 NSGLKVHK 535
Cdd:COG5189   411 LNGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
262-648 8.81e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 8.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 262 KPYECDTCGKTFSNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSI------------------HFGDKPYKCD 323
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLrthhnnpsdlnskslplsNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 324 ECEKSFNYSSLLIQHKVIHTGEKPYECDECGKAFRNSSGLIVHKRIHTGEK-------PYKCDICGKAFSYSSGLAVHKS 396
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 397 IHPGKKAHECKDCGKSFSYNSLLLQHKTIHTGERPYVCDVCGKTFRNNSGLKVHRRLHTGEKPYKCDVCGKAYISRSSLK 476
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 477 NHKGIHMGE-------KPYKCSYCEKSFNYSSALEQHKR--IHTRE--KPFGCDE--CGKAFRNNSGLKVHKRIHTGERP 543
Cdd:COG5048   272 SSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 544 YKC--EECGKAYISLSSLINHKSVHP-----GEKPFKCD--ECEKAFITYRTLLNHKKIHLGEKP--YKCDVCEKSFNYT 612
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQQykdlkNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1907081572 613 SLLSQHKRVHTREKPFECdRCEKVFRNNSSLKVHKR 648
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLC-SILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-583 1.04e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.47  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 178 KPYKCDECGKAYMSYSSLINHKSTHSGEKNCKC--DECGKSFNYSSVLDQHKRIHTGEKPYECgeCGKAFRNSSGLRVHK 255
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 256 RIHTGEKP-YECDTCGKTFSNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSIHfgDKPYKCdECEKSFNYSSL 334
Cdd:COG5048   110 LSSSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP--PLPANS-LSKDPSSNLSL 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 335 LIQHKVIHTGEKPYECDECGKAFRNSSGLIVHKRIHTgEKPYKCDICGKAFSYSSGLAVHKSIHPGKKAHECKDCGKSFS 414
Cdd:COG5048   187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 415 YNSLLLQHKTIHTGER-------PYVCDVCGKTFRNNSGLKVHRR--LHTGE--KPYKCDV--CGKAYISRSSLKNHKGI 481
Cdd:COG5048   266 PTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 482 HMGEKPYKCSYCEKSFNYSSAL-------EQHKRIHTREKPFGCD--ECGKAFRNNSGLKVHKRIHTGERP--YKCEECG 550
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFSPLLnneppqsLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1907081572 551 KAYISLSSLINHKSVHPGEKPFKCDECEKAFIT 583
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
120-535 2.34e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 2.34e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 120 DKKLHKCDECGKSFKYNSRLVQHKIMHTGEKRYEC--DDCRGTFRSSSSLRVHKRIHTGEKPYKCDECGKAYMSY--SSL 195
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKasSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 196 INHKSTHS--GEKNCKCDECGKSFNYSSVLDQHKRIHTGEKPYECGECGKAFRNSSGLRVHKRIHtgekpyecdTCGKTF 273
Cdd:COG5048   110 LSSSSSNSndNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN---------SLSKDP 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 274 SNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSIHFGDKPYKCDECEKSFNYSSLLIQHKVIHTGEKPYECDEC 353
Cdd:COG5048   181 SSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 354 GKAFRNSSGLIVHKRIHTGE-------KPYKCDICGKAFSYSSGLAVHK--SIHPGK--KAHEC--KDCGKSFSYNSLLL 420
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 421 QHKTIHTGERPYVCDVCGKTFRNNSGLK-------VHRRLHTGEKPYKCDV--CGKAYISRSSLKNHKGIHMGEKP--YK 489
Cdd:COG5048   341 RHILLHTSISPAKEKLLNSSSKFSPLLNneppqslQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCK 420

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 1907081572 490 CSYCEKSFNYSSALEQHKRIHTREKPFGCDECGKAFRNNSGLKVHK 535
Cdd:COG5048   421 NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 428-480 4.25e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 50.10  E-value: 4.25e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907081572 428 GERPYVCDV--CGKTFRNNSGLKVHRrLH--------------------TGEKPYKCDVCGKAYISRSSLKNHKG 480
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM-LHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 232-283 1.04e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 1.04e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907081572 232 GEKPYECG--ECGKAFRNSSGLRVHKR-------------------IHTGEKPYECDTCGKTFSNSSGLRVHK 283
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 43-255 3.18e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 3.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572  43 FPKWKILKEGKSSIREM---IDT-HTNAANIKLEQDDETSEKSFYPSTNTMHQTIPTEPNCTKQGEHTENING----NVH 114
Cdd:COG5189   214 LKKLSLIEEKKFPERVRsryIDIgHMMDTHQFYLEDVDLMDDDILGPSNEEMLYKYISPSQGSAELFEESSLGfdyeFIH 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 115 PA----HIADKKLHKCDECGKSFKYNSRLVQHKIMHTGEKryecddcrgTFRSSSSLRVHKrihtGEKPYKCD--ECGKA 188
Cdd:COG5189   294 KSvgnkEIRGGISTGEMIDVRKLPCTNSSSNGKLAHGGER---------NIDTPSRMLKVK----DGKPYKCPveGCNKK 360

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907081572 189 YMSYSSLINHKsthsgekncKCDECGKSFNYSSVLDQHKRIHTGEKPYECGECGKAFRNSSGLRVHK 255
Cdd:COG5189   361 YKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 486-534 3.83e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 39.85  E-value: 3.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907081572 486 KPYkCSYCEKSFNYSSALEQHKRIHTrekpFGCDECGKAFRNNSGLKVH 534
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-303 3.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 3.91e-04
                          10        20
                  ....*....|....*....|....*
gi 1907081572 279 LRVHKRIHTGEKPYECDECGKAFIT 303
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
251-275 8.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 8.57e-04
                          10        20
                  ....*....|....*....|....*
gi 1907081572 251 LRVHKRIHTGEKPYECDTCGKTFSN 275
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
166-189 1.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.14e-03
                          10        20
                  ....*....|....*....|....
gi 1907081572 166 SLRVHKRIHTGEKPYKCDECGKAY 189
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-247 1.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.33e-03
                          10        20
                  ....*....|....*....|....*
gi 1907081572 223 LDQHKRIHTGEKPYECGECGKAFRN 247
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-387 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....*
gi 1907081572 363 LIVHKRIHTGEKPYKCDICGKAFSY 387
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
810-833 1.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.53e-03
                          10        20
                  ....*....|....*....|....
gi 1907081572 810 LDQHKRIHTGKKPYRCNDCGKAFN 833
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 483-563 1.73e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 483 MGEKPYKCSY--CEKSFNYSSALEQHkRIHTREKPfgcdecgKAFRNNSGLKvHKRIHTGERPYKCEECGKAYISLSSLI 560
Cdd:COG5189   345 KDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSPEK-MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1907081572 561 NHK 563
Cdd:COG5189   416 YHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
642-667 2.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 1907081572 642 SLKVHKRIHTGEKPYECDICGKAYIS 667
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 346-394 2.34e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 2.34e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1907081572 346 KPYeCDECGKAFRNSSGLIVHKRIHTgekpYKCDICGKAFSYSSGLAVH 394
Cdd:cd20908     1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
531-555 2.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|....*
gi 1907081572 531 LKVHKRIHTGERPYKCEECGKAYIS 555
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 595-675 5.99e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 5.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907081572 595 LGEKPYKCDV--CEKSFNYTSLLSQHkRVHtrekpfecDRCEKVFRNNSSLKVHKRIHTGEKPYECDICGKAYISHSSLI 672
Cdd:COG5189   345 KDGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ...
gi 1907081572 673 NHK 675
Cdd:COG5189   416 YHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
335-359 6.61e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.61e-03
                          10        20
                  ....*....|....*....|....*
gi 1907081572 335 LIQHKVIHTGEKPYECDECGKAFRN 359
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
447-471 7.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.01e-03
                          10        20
                  ....*....|....*....|....*
gi 1907081572 447 LKVHRRLHTGEKPYKCDVCGKAYIS 471
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 707-759 9.38e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 9.38e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907081572 707 LGEKPFKC--VECGKSFSYSSLLSQHKR-------------------IHTGEKPYVCDWCGKAFRNSSGLTVHK 759
Cdd:COG5189   345 KDGKPYKCpvEGCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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