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Conserved domains on  [gi|1907083413|ref|XP_036012940|]
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regulatory-associated protein of mTOR isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 879-1174 3.42e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 3.42e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  879 SVVKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRVWknfaDLE 955
Cdd:cd00200     13 TCVAFSPDGKLLATGSGDGTIKvWDLETGELLRTLkgHTGPVRDVAASA-------DGTYLASGSSDKTIRLW----DLE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  956 KNpEMVTAWQGLSDMLpttrgagMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVA 1035
Cdd:cd00200     82 TG-ECVRTLTGHTSYV-------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSPDGTFVAS 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1036 GLGDGSIRVYDrrMALSECrVMTYREHTAWVVKayLQKHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDI 1113
Cdd:cd00200    153 SSQDGTIKLWD--LRTGKC-VATLTGHTGEVNS--VAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907083413 1114 HPQANLIACGSMNqftaiyngngeliNNIKYYDGFMGQRV-------GAISCLAFHPHWPHLAVGSND 1174
Cdd:cd00200    228 SPDGYLLASGSED-------------GTIRVWDLRTGECVqtlsghtNSVTSLAWSPDGKRLASGSAD 282
Raptor_N super family cl46306
Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor ...
 8-58 2.98e-18

Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure. It conserves the characteriztic cys/his dyad of the caspases suggesting it may have a peptidase activity.


The actual alignment was detected with superfamily member pfam14538:

Pssm-ID: 480646  Cd Length: 152  Bit Score: 82.71  E-value: 2.98e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907083413    8 IKNCSCFIsenHDENYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSF 58
Cdd:pfam14538  105 TSNGEIWV---FNKDYTQYIPLSIYDLFSWLGSPSIFIFDCSNAGNLLNAF 152
HEAT COG1413
HEAT repeat [General function prediction only];
415-522 1.43e-08

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 54.63  E-value: 1.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  415 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 494
Cdd:COG1413     53 LEALKDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALG--------RLGDPAAVPA 113

                           90       100
                   ....*....|....*....|....*...
gi 1907083413  495 nvammLAQLINDGSPMVRKELVVALSHL 522
Cdd:COG1413    114 -----LLEALKDPDWEVRRAAARALGRL 136
COG5096 super family cl34899
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 324-548 1.72e-04

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


The actual alignment was detected with superfamily member COG5096:

Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 45.87  E-value: 1.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  324 IFPYVLKLLQSSARELRPLLVFIW---AK------ILAVDSscqadLVKDNGHKyflsvlaDPYMpaehRTMTAFILAVI 394
Cdd:COG5096     56 LFPDVIKNVATRDVELKRLLYLYLeryAKlkpelaLLAVNT-----IQKDLQDP-------NEEI----RGFALRTLSLL 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  395 vnsyttgQEACLQGNLIAICLEQLSDPHPLLRQWVAICLGRIWQnFDSARWCGVRDSAHEKLysLLSDPIPEVRCAAVFA 474
Cdd:COG5096    120 -------RVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYR-LDKDLYHELGLIDILKE--LVADSDPIVIANALAS 189

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907083413  475 LGTFVGNSAErtDHSTTIDHNVAMMLAQLINDGSPMVRKELVVALSHLVVQYESN---FCT-VALQFMEEEKNYPLPS 548
Cdd:COG5096    190 LAEIDPELAH--GYSLEVILRIPQLDLLSLSVSTEWLLLIILEVLTERVPTTPDSaedFEErLSPPLQHNNAEVLLIA 265
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 879-1174 3.42e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 3.42e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  879 SVVKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRVWknfaDLE 955
Cdd:cd00200     13 TCVAFSPDGKLLATGSGDGTIKvWDLETGELLRTLkgHTGPVRDVAASA-------DGTYLASGSSDKTIRLW----DLE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  956 KNpEMVTAWQGLSDMLpttrgagMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVA 1035
Cdd:cd00200     82 TG-ECVRTLTGHTSYV-------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSPDGTFVAS 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1036 GLGDGSIRVYDrrMALSECrVMTYREHTAWVVKayLQKHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDI 1113
Cdd:cd00200    153 SSQDGTIKLWD--LRTGKC-VATLTGHTGEVNS--VAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907083413 1114 HPQANLIACGSMNqftaiyngngeliNNIKYYDGFMGQRV-------GAISCLAFHPHWPHLAVGSND 1174
Cdd:cd00200    228 SPDGYLLASGSED-------------GTIRVWDLRTGECVqtlsghtNSVTSLAWSPDGKRLASGSAD 282
Raptor_N pfam14538
Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor ...
 8-58 2.98e-18

Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure. It conserves the characteriztic cys/his dyad of the caspases suggesting it may have a peptidase activity.


Pssm-ID: 464202  Cd Length: 152  Bit Score: 82.71  E-value: 2.98e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907083413    8 IKNCSCFIsenHDENYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSF 58
Cdd:pfam14538  105 TSNGEIWV---FNKDYTQYIPLSIYDLFSWLGSPSIFIFDCSNAGNLLNAF 152
WD40 COG2319
WD40 repeat [General function prediction only];
890-1183 3.45e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.45e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  890 IAVADKD-SICFWDWEKGEKLDYF--HNGnprytRVTAMEYL-NGQdcsLLLTATDDGAIRVWknfaDLEKNPEMVTawq 965
Cdd:COG2319    135 LASGSADgTVRLWDLATGKLLRTLtgHSG-----AVTSVAFSpDGK---LLASGSDDGTVRLW----DLATGKLLRT--- 199

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  966 glsdmLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAGLGDGSIRVY 1045
Cdd:COG2319    200 -----LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1046 DRRmalSECRVMTYREHTAWVVKAYLqkHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDIHPQANLIACG 1123
Cdd:COG2319    274 DLA---TGELLRTLTGHSGGVNSVAF--SPDGkLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKTLASG 348

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907083413 1124 SMNQFTAIYN-GNGELINNIKyydgfmgQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1183
Cdd:COG2319    349 SDDGTVRLWDlATGELLRTLT-------GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
HEAT COG1413
HEAT repeat [General function prediction only];
415-522 1.43e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 54.63  E-value: 1.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  415 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 494
Cdd:COG1413     53 LEALKDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALG--------RLGDPAAVPA 113

                           90       100
                   ....*....|....*....|....*...
gi 1907083413  495 nvammLAQLINDGSPMVRKELVVALSHL 522
Cdd:COG1413    114 -----LLEALKDPDWEVRRAAARALGRL 136
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 415-520 2.59e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.87  E-value: 2.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  415 LEQL-SDPHPLLRQWVAICLGRIwqNFDSARwcgvrdsahEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTID 493
Cdd:pfam13646    5 LQALlRDPDPEVRAAAIRALGRI--GDPEAV---------PALLELLKDEDPAVRRAAAEALG--------KIGDPEALP 65

                           90       100
                   ....*....|....*....|....*..
gi 1907083413  494 HnvamMLAQLINDGSPMVRKELVVALS 520
Cdd:pfam13646   66 A----LLELLRDDDDDVVRAAAAEALA 88
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 324-548 1.72e-04

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 45.87  E-value: 1.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  324 IFPYVLKLLQSSARELRPLLVFIW---AK------ILAVDSscqadLVKDNGHKyflsvlaDPYMpaehRTMTAFILAVI 394
Cdd:COG5096     56 LFPDVIKNVATRDVELKRLLYLYLeryAKlkpelaLLAVNT-----IQKDLQDP-------NEEI----RGFALRTLSLL 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  395 vnsyttgQEACLQGNLIAICLEQLSDPHPLLRQWVAICLGRIWQnFDSARWCGVRDSAHEKLysLLSDPIPEVRCAAVFA 474
Cdd:COG5096    120 -------RVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYR-LDKDLYHELGLIDILKE--LVADSDPIVIANALAS 189

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907083413  475 LGTFVGNSAErtDHSTTIDHNVAMMLAQLINDGSPMVRKELVVALSHLVVQYESN---FCT-VALQFMEEEKNYPLPS 548
Cdd:COG5096    190 LAEIDPELAH--GYSLEVILRIPQLDLLSLSVSTEWLLLIILEVLTERVPTTPDSaedFEErLSPPLQHNNAEVLLIA 265
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 879-1174 3.42e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 98.18  E-value: 3.42e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  879 SVVKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRVWknfaDLE 955
Cdd:cd00200     13 TCVAFSPDGKLLATGSGDGTIKvWDLETGELLRTLkgHTGPVRDVAASA-------DGTYLASGSSDKTIRLW----DLE 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  956 KNpEMVTAWQGLSDMLpttrgagMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVA 1035
Cdd:cd00200     82 TG-ECVRTLTGHTSYV-------SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAFSPDGTFVAS 152

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1036 GLGDGSIRVYDrrMALSECrVMTYREHTAWVVKayLQKHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDI 1113
Cdd:cd00200    153 SSQDGTIKLWD--LRTGKC-VATLTGHTGEVNS--VAFSPDGeKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAF 227

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907083413 1114 HPQANLIACGSMNqftaiyngngeliNNIKYYDGFMGQRV-------GAISCLAFHPHWPHLAVGSND 1174
Cdd:cd00200    228 SPDGYLLASGSED-------------GTIRVWDLRTGECVqtlsghtNSVTSLAWSPDGKRLASGSAD 282
Raptor_N pfam14538
Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor ...
 8-58 2.98e-18

Raptor N-terminal CASPase like domain; This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure. It conserves the characteriztic cys/his dyad of the caspases suggesting it may have a peptidase activity.


Pssm-ID: 464202  Cd Length: 152  Bit Score: 82.71  E-value: 2.98e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907083413    8 IKNCSCFIsenHDENYTQYIPLSIYDLQTWMGSPSIFVYDCSNAGLIVKSF 58
Cdd:pfam14538  105 TSNGEIWV---FNKDYTQYIPLSIYDLFSWLGSPSIFIFDCSNAGNLLNAF 152
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 975-1182 9.31e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.00  E-value: 9.31e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  975 RGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAGLGDGSIRVYDRRmalSEC 1054
Cdd:cd00200      9 TGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE---TGE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1055 RVMTYREHTAWVvkAYLQKHPEGHIVSVS-VNGDVRFFDPRMPESVNVMQ-IVKGLTALDIHPQANLIACGSMNQFTAIY 1132
Cdd:cd00200     85 CVRTLTGHTSYV--SSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQDGTIKLW 162

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1907083413 1133 NG-NGELINNIKYYDGFmgqrvgaISCLAFHPHWPHLAVGSNDYYISVYSV 1182
Cdd:cd00200    163 DLrTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDL 206
WD40 COG2319
WD40 repeat [General function prediction only];
890-1183 3.45e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 3.45e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  890 IAVADKD-SICFWDWEKGEKLDYF--HNGnprytRVTAMEYL-NGQdcsLLLTATDDGAIRVWknfaDLEKNPEMVTawq 965
Cdd:COG2319    135 LASGSADgTVRLWDLATGKLLRTLtgHSG-----AVTSVAFSpDGK---LLASGSDDGTVRLW----DLATGKLLRT--- 199

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  966 glsdmLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAGLGDGSIRVY 1045
Cdd:COG2319    200 -----LTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGRLLASGSADGTVRLW 273

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1046 DRRmalSECRVMTYREHTAWVVKAYLqkHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQI-VKGLTALDIHPQANLIACG 1123
Cdd:COG2319    274 DLA---TGELLRTLTGHSGGVNSVAF--SPDGkLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPDGKTLASG 348

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907083413 1124 SMNQFTAIYN-GNGELINNIKyydgfmgQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1183
Cdd:COG2319    349 SDDGTVRLWDlATGELLRTLT-------GHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
871-1183 2.02e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 2.02e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  871 LNRNPGVPSVVKFHPFTPCIAVADKD-SICFWDWEKGEKLDYF--HNGNPRYTRVTAmeylngqDCSLLLTATDDGAIRV 947
Cdd:COG2319     74 LLGHTAAVLSVAFSPDGRLLASASADgTVRLWDLATGLLLRTLtgHTGAVRSVAFSP-------DGKTLASGSADGTVRL 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  948 WknfaDLEKNPEMVTawqglsdmLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCD 1027
Cdd:COG2319    147 W----DLATGKLLRT--------LTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFS 213

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1028 SHRSLIVAGLGDGSIRVYDrrMALSECrVMTYREHTAWVVK-AYlqkHPEG-HIVSVSVNGDVRFFDPRMPESVNVMQIV 1105
Cdd:COG2319    214 PDGKLLASGSADGTVRLWD--LATGKL-LRTLTGHSGSVRSvAF---SPDGrLLASGSADGTVRLWDLATGELLRTLTGH 287

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1106 KG-LTALDIHPQANLIACGSMNQFTAIYN-GNGELINNIKyydgfmgQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1183
Cdd:COG2319    288 SGgVNSVAFSPDGKLLASGSDDGTVRLWDlATGKLLRTLT-------GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 881-1092 2.93e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 2.93e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  881 VKFHPFTPCIAVADKDSICF-WDWEKGEKLDYF--HNGNprytrVTAMEYLngQDCSLLLTATDDGAIRVWknfaDLEKN 957
Cdd:cd00200     57 VAASADGTYLASGSSDKTIRlWDLETGECVRTLtgHTSY-----VSSVAFS--PDGRILSSSSRDKTIKVW----DVETG 125

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  958 pEMVTAWQGLSDmlpttrgAGMVVDWEQETGLLMSSGDVRIVRIWDT--------------------------------- 1004
Cdd:cd00200    126 -KCLTTLRGHTD-------WVNSVAFSPDGTFVASSSQDGTIKLWDLrtgkcvatltghtgevnsvafspdgekllssss 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1005 DRETKVQDIPTGADSC--------VTSLSCDSHRSLIVAGLGDGSIRVYDRRMAlsECrVMTYREHTAWVVKAYLqkHPE 1076
Cdd:cd00200    198 DGTIKLWDLSTGKCLGtlrghengVNSVAFSPDGYLLASGSEDGTIRVWDLRTG--EC-VQTLSGHTNSVTSLAW--SPD 272

                          250
                   ....*....|....*..
gi 1907083413 1077 GH-IVSVSVNGDVRFFD 1092
Cdd:cd00200    273 GKrLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
877-1183 1.77e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.71  E-value: 1.77e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  877 VPSVVKFHPFTPCIAVADKDSICFWDWEKGEKLDYFHNGNPRYTRVTAMeylngQDCSLLLTATDDGAIRVWknfaDLEk 956
Cdd:COG2319     39 VASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS-----PDGRLLASASADGTVRLW----DLA- 108

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  957 NPEMVTAWQGLSDMLPTtrgagmvVDWEQETGLLMSSGDVRIVRIWDTDRETKVQDIpTGADSCVTSLSCDSHRSLIVAG 1036
Cdd:COG2319    109 TGLLLRTLTGHTGAVRS-------VAFSPDGKTLASGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLLASG 180

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1037 LGDGSIRVYDrrmALSECRVMTYREHTAWVVK-AYlqkHPEGH-IVSVSVNGDVRFFDprmPESVNVMQIVKG----LTA 1110
Cdd:COG2319    181 SDDGTVRLWD---LATGKLLRTLTGHTGAVRSvAF---SPDGKlLASGSADGTVRLWD---LATGKLLRTLTGhsgsVRS 251

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907083413 1111 LDIHPQANLIACGSMNQFTAIYN-GNGELInnikyydGFMGQRVGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1183
Cdd:COG2319    252 VAFSPDGRLLASGSADGTVRLWDlATGELL-------RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
962-1183 8.87e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 8.87e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  962 TAWQGLSDMLPTTRGAGMVVDWEQETGLLMSSGDVRIVRIWDTDRETKVQdIPTGADSCVTSLSCDSHRSLIVAGLGDGS 1041
Cdd:COG2319     23 AALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLA-TLLGHTAAVLSVAFSPDGRLLASASADGT 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1042 IRVYDrrmALSECRVMTYREHTAWVVKAYLqkHPEGH-IVSVSVNGDVRFFDPRMPESVNVMQIVKG-LTALDIHPQANL 1119
Cdd:COG2319    102 VRLWD---LATGLLLRTLTGHTGAVRSVAF--SPDGKtLASGSADGTVRLWDLATGKLLRTLTGHSGaVTSVAFSPDGKL 176

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907083413 1120 IACGSMNQFTAIYN-GNGELINNIKYYDgfmgqrvGAISCLAFHPHWPHLAVGSNDYYISVYSVE 1183
Cdd:COG2319    177 LASGSDDGTVRLWDlATGKLLRTLTGHT-------GAVRSVAFSPDGKLLASGSADGTVRLWDLA 234
HEAT COG1413
HEAT repeat [General function prediction only];
415-522 1.43e-08

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 54.63  E-value: 1.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  415 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 494
Cdd:COG1413     53 LEALKDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALG--------RLGDPAAVPA 113

                           90       100
                   ....*....|....*....|....*...
gi 1907083413  495 nvammLAQLINDGSPMVRKELVVALSHL 522
Cdd:COG1413    114 -----LLEALKDPDWEVRRAAARALGRL 136
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 890-1185 2.75e-07

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 53.77  E-value: 2.75e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  890 IAVADKD-SICFWDWEKGEKLDYFHNGNPRYT-----RVTAMEYLNGQdcslLLTATDDGAIRVWKNFADLEKNPEmVTA 963
Cdd:cd22857     47 LAVARKNgTVEVLDPENGDLLASFSDSEPATKlseedHFVGLHLFSGT----LLTCTSKGSLRSTKLPDDSTASSS-PTA 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  964 WQGLSDMLPTTRGagmvvdwEQETGLLMSSGDVRIVRIWDTdrETKVQDI---------------PTgadsCVTS---LS 1025
Cdd:cd22857    122 WVCLGGNLLCMRV-------DPNENYFAFGGKEVELNVWDL--EEKPGKIwraknvpndslglrvPV----WVTDltfLS 188

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1026 CDSHRSlIVAGLGDGSIRVYD----RRmalsecRVM--TYREHTAWVVkaylQKHPEGHIVSVSVN-GDVRFFDPRmpes 1098
Cdd:cd22857    189 KDDHRK-IVTGTGYHQVRLYDtraqRR------PVVsvDFGETPIKAV----AEDPDGHTVYVGDTsGDLASIDLR---- 253

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413 1099 vnvmqivkgltaldihpqanliacgsmnqftaiyngNGELINNikyYDGFMGqrvGAISCLAFHPHWPHLAVGSNDYYIS 1178
Cdd:cd22857    254 ------------------------------------TGKLLGC---FKGKCG---GSIRSIARHPELPLIASCGLDRYLR 291


                   ....*..
gi 1907083413 1179 VYSVEKR 1185
Cdd:cd22857    292 IWDTETR 298
HEAT COG1413
HEAT repeat [General function prediction only];
415-522 4.69e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 50.40  E-value: 4.69e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  415 LEQLSDPHPLLRQWVAICLGRIWQnfdsarwcgvrDSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDH 494
Cdd:COG1413     22 IAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALG--------RIGDPEAVPA 82

                           90       100
                   ....*....|....*....|....*...
gi 1907083413  495 nvammLAQLINDGSPMVRKELVVALSHL 522
Cdd:COG1413     83 -----LIAALKDEDPEVRRAAAEALGRL 105
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 415-520 2.59e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.87  E-value: 2.59e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  415 LEQL-SDPHPLLRQWVAICLGRIwqNFDSARwcgvrdsahEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTID 493
Cdd:pfam13646    5 LQALlRDPDPEVRAAAIRALGRI--GDPEAV---------PALLELLKDEDPAVRRAAAEALG--------KIGDPEALP 65

                           90       100
                   ....*....|....*....|....*..
gi 1907083413  494 HnvamMLAQLINDGSPMVRKELVVALS 520
Cdd:pfam13646   66 A----LLELLRDDDDDVVRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
411-476 2.93e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 45.00  E-value: 2.93e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907083413  411 IAICLEQLSDPHPLLRQWVAICLGRIWqnfdsarwcgvRDSAHEKLYSLLSDPIPEVRCAAVFALG 476
Cdd:COG1413     80 VPALIAALKDEDPEVRRAAAEALGRLG-----------DPAAVPALLEALKDPDWEVRRAAARALG 134
COG5096 COG5096
Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular ...
 324-548 1.72e-04

Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 227427 [Multi-domain]  Cd Length: 757  Bit Score: 45.87  E-value: 1.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  324 IFPYVLKLLQSSARELRPLLVFIW---AK------ILAVDSscqadLVKDNGHKyflsvlaDPYMpaehRTMTAFILAVI 394
Cdd:COG5096     56 LFPDVIKNVATRDVELKRLLYLYLeryAKlkpelaLLAVNT-----IQKDLQDP-------NEEI----RGFALRTLSLL 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083413  395 vnsyttgQEACLQGNLIAICLEQLSDPHPLLRQWVAICLGRIWQnFDSARWCGVRDSAHEKLysLLSDPIPEVRCAAVFA 474
Cdd:COG5096    120 -------RVKELLGNIIDPIKKLLTDPHAYVRKTAALAVAKLYR-LDKDLYHELGLIDILKE--LVADSDPIVIANALAS 189

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907083413  475 LGTFVGNSAErtDHSTTIDHNVAMMLAQLINDGSPMVRKELVVALSHLVVQYESN---FCT-VALQFMEEEKNYPLPS 548
Cdd:COG5096    190 LAEIDPELAH--GYSLEVILRIPQLDLLSLSVSTEWLLLIILEVLTERVPTTPDSaedFEErLSPPLQHNNAEVLLIA 265
HEAT COG1413
HEAT repeat [General function prediction only];
450-522 1.38e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.38  E-value: 1.38e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907083413  450 DSAHEKLYSLLSDPIPEVRCAAVFALGtfvgnsaeRTDHSTTIDHnvammLAQLINDGSPMVRKELVVALSHL 522
Cdd:COG1413     15 PAAVPALIAALADEDPDVRAAAARALG--------RLGDPRAVPA-----LLEALKDPDPEVRAAAAEALGRI 74
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 456-479 6.14e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.58  E-value: 6.14e-03
                           10        20
                   ....*....|....*....|....
gi 1907083413  456 LYSLLSDPIPEVRCAAVFALGTFV 479
Cdd:pfam02985    5 LLKLLNDPSPEVREAAAEALGELA 28
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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