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Conserved domains on  [gi|1907083510|ref|XP_036012954|]
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keratin-associated protein 4-6 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Keratin_B2 super family cl37504
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-147 8.55e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


The actual alignment was detected with superfamily member pfam01500:

Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.12  E-value: 8.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083510   3 SSCCGSVCSEEG-CSQGCCQPSCCVSSCCRPQCCQSVCCRPSCCRPSCCVSSCcrPQCCQSACCQPTCCRPSCCRPSCCI 81
Cdd:pfam01500   7 SFCGFPTCSTGGtCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTGCGG 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907083510  82 SSCCQPSCGGSSCCGSSCC--RPCCRPCCRPCCCLRPVCGQVCCQT-----TCYRPTCVISTCPRPMCCATPC 147
Cdd:pfam01500  85 IGYGQEGSSGAVSSRTRWCrpDCRVEGTCLPPCCVVSCTPPTCCQLhhaqaSCCRPSYCGQSCCRPACCCQCS 157
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-147 8.55e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.12  E-value: 8.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083510   3 SSCCGSVCSEEG-CSQGCCQPSCCVSSCCRPQCCQSVCCRPSCCRPSCCVSSCcrPQCCQSACCQPTCCRPSCCRPSCCI 81
Cdd:pfam01500   7 SFCGFPTCSTGGtCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTGCGG 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907083510  82 SSCCQPSCGGSSCCGSSCC--RPCCRPCCRPCCCLRPVCGQVCCQT-----TCYRPTCVISTCPRPMCCATPC 147
Cdd:pfam01500  85 IGYGQEGSSGAVSSRTRWCrpDCRVEGTCLPPCCVVSCTPPTCCQLhhaqaSCCRPSYCGQSCCRPACCCQCS 157
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
14-81 8.26e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 38.38  E-value: 8.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083510  14 GCSQGCCQPSCCVSSCCRPQCCQSVCCRPSCCRPSCCVSSCCRP--QCCQSACCQPTCCRPSCCRPSCCI 81
Cdd:COG3901   614 LALAAAALARRRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIinECCCCCCLCCRRCQDDPLCPPRIK 683
 
Name Accession Description Interval E-value
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 3-147 8.55e-15

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 67.12  E-value: 8.55e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083510   3 SSCCGSVCSEEG-CSQGCCQPSCCVSSCCRPQCCQSVCCRPSCCRPSCCVSSCcrPQCCQSACCQPTCCRPSCCRPSCCI 81
Cdd:pfam01500   7 SFCGFPTCSTGGtCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTC--QPCCQTSCCQPTCCQTSSCQTGCGG 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907083510  82 SSCCQPSCGGSSCCGSSCC--RPCCRPCCRPCCCLRPVCGQVCCQT-----TCYRPTCVISTCPRPMCCATPC 147
Cdd:pfam01500  85 IGYGQEGSSGAVSSRTRWCrpDCRVEGTCLPPCCVVSCTPPTCCQLhhaqaSCCRPSYCGQSCCRPACCCQCS 157
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
44-87 1.04e-13

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 61.24  E-value: 1.04e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907083510  44 CCRPSCCVSSCCRPQCCQSACCQPTCCRPSCCRPSCCISSCCQP 87
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQP 44
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
34-78 1.30e-13

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 60.86  E-value: 1.30e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907083510  34 CCQSVCCRPSCCRPSCCVSSCCRPQCCQSACCQPTCCRPSCCRPS 78
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
29-73 2.02e-13

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 60.47  E-value: 2.02e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907083510  29 CCRPQCCQSVCCRPSCCRPSCCVSSCCRPQCCQSACCQPTCCRPS 73
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
24-68 5.61e-13

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 59.32  E-value: 5.61e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1907083510  24 CCVSSCCRPQCCQSVCCRPSCCRPSCCVSSCCRPQCCQSACCQPT 68
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
15-57 1.19e-12

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 58.55  E-value: 1.19e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1907083510  15 CSQGCCQPSCCVSSCCRPQCCQSVCCRPSCCRPSCCVSSCCRP 57
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQP 44
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 34-148 1.46e-09

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 53.26  E-value: 1.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083510  34 CCQSVCCRPSCCRPSCCVSSCCRPQCCQSACCQPTCCRPSCCRPSCCISSCCQPSCGGSSCCGSSCCRPCCRPCC----- 108
Cdd:pfam01500   4 CGTSFCGFPTCSTGGTCGSGCCQPCCCQSSCCRPSCCQTSCCQPTTFQSSCCRPTCQPCCQTSCCQPTCCQTSSCqtgcg 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1907083510 109 -----RPCCCLRPVCGQVCCQTTCYRPTCVISTCPRPMCCATPCC 148
Cdd:pfam01500  84 gigygQEGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCC 128
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
10-50 2.25e-09

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 50.07  E-value: 2.25e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1907083510  10 CSEEGCSQGCCQPSCCVSSCCRPQCCQSVCCRPSCCRPSCC 50
Cdd:pfam13885   2 CQPSCCQPSCCQPSCCQPSCCQPSCCQPSCCRPSCCRSSCC 42
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
3-48 1.05e-07

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 45.84  E-value: 1.05e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1907083510   3 SSCCGSVCseegCSQGCCQPSCCVSSCCRPQCCQSVCCRPSCCRPS 48
Cdd:pfam13885   4 PSCCQPSC----CQPSCCQPSCCQPSCCQPSCCRPSCCRSSCCQPT 45
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
 2-69 1.91e-06

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 44.78  E-value: 1.91e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907083510   2 VSSCCGSVCSEEGCSQGCCQPSCCVSSCCRPQCCQSVCCRP-----SCCRPSCCVSSCCRPQCCqSACCQPTC 69
Cdd:pfam01500  90 EGSSGAVSSRTRWCRPDCRVEGTCLPPCCVVSCTPPTCCQLhhaqaSCCRPSYCGQSCCRPACC-CQCSEPTC 161
Keratin_B2_2 pfam13885
Keratin, high sulfur B2 protein;
64-140 7.05e-05

Keratin, high sulfur B2 protein;


Pssm-ID: 464017 [Multi-domain]  Cd Length: 45  Bit Score: 38.13  E-value: 7.05e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907083510  64 CCQPTCCRPSCCRPSCCISSCCQPscggssccgssccrpccrpccrpccclrpvcgqVCCQTTCYRPTCVISTCPRP 140
Cdd:pfam13885   1 CCQPSCCQPSCCQPSCCQPSCCQP---------------------------------SCCQPSCCRPSCCRSSCCQP 44
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 1-86 3.58e-04

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 38.64  E-value: 3.58e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083510   1 MVSSCCGSVCSEEGCSQGCCQP-SCCVSSCCRPQCCQSVCCRPSCCRPSCCVSSCCRPQCCQSACCQPTCCRPSCCRPSC 79
Cdd:pfam05287   1 MSYNCCSGNFSSRSLRNHLHYPvSSCGSSCPSNLSYSTDLCSPSSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSY 80


                  ....*..
gi 1907083510  80 CISSCCQ 86
Cdd:pfam05287  81 CVPSPCQ 87
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 2-87 4.02e-04

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 38.64  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083510   2 VSSCCGSVCSEEGCSQGC--CQPSCCVSSCCRPQCCQSVCCRPSCCRPSCCVSSCCRPQCCQSACCQPTCCRPSCCRPSC 79
Cdd:pfam05287  82 VPSPCQRSCYSPRTSCVCspCQTTSAGSLGFGSSSCQSLGYGSNSCQPLGCGSSGFRPLGCLSKGFQSLGYGSSFCRPSY 161


                  ....*...
gi 1907083510  80 CISSCCQP 87
Cdd:pfam05287 162 VSSRSYQP 169
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
14-81 8.26e-04

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 38.38  E-value: 8.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083510  14 GCSQGCCQPSCCVSSCCRPQCCQSVCCRPSCCRPSCCVSSCCRP--QCCQSACCQPTCCRPSCCRPSCCI 81
Cdd:COG3901   614 LALAAAALARRRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIinECCCCCCLCCRRCQDDPLCPPRIK 683
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
24-86 2.17e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 37.22  E-value: 2.17e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907083510  24 CCVSSCCRPQCCQSVCCRPSCCRPSCCVSSCCRPQCCQSACCQPTCCRPSCCRPSCCISSCCQ 86
Cdd:COG3901   604 FFFRRLCLLGLALAAAALARRRLWRRRRRECCCGCCCCCCKCCCIVIIIDGIIIINECCCCCC 666
PMG pfam05287
PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and ...
 3-133 4.28e-03

PMG protein; This family consists of several mouse anagen-specific protein mKAP13 (PMG1 and PMG2). PMG1 and 2 contain characteriztic repeats reminiscent of the keratin-associated proteins (KAPs). Both genes are expressed in growing hair follicles in skin as well as in sebaceous and eccrine sweat glands. Interestingly, expression is also detected in the mammary epithelium where it is limited to the onset of the pubertal growth phase and is independent of ovarian hormones. Their broad, developmentally controlled expression pattern, together with their unique amino acid composition, demonstrate that pmg-1 and pmg-2 constitute a novel KAP gene family participating in the differentiation of all epithelial cells forming the epidermal appendages.


Pssm-ID: 283053 [Multi-domain]  Cd Length: 180  Bit Score: 35.56  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907083510   3 SSCCGSVCSEEGCSQGCCQPSCCVSSCCRPQCCQSVCCRPSCCRPSCCV-SSCCRPQCCQSACCQPTCCRPSCCRPSCCI 81
Cdd:pfam05287  44 SSCQLGSSLRDNCQETCGEPTSCQTSSCEPCTSSTSYCVPSPCQRSCYSpRTSCVCSPCQTTSAGSLGFGSSSCQSLGYG 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1907083510  82 SSCCQPSCGGSSC--CGSSCCRPCCRPCCRPCCCLRPVCGQVCCQTTCYRPTCV 133
Cdd:pfam05287 124 SNSCQPLGCGSSGfrPLGCLSKGFQSLGYGSSFCRPSYVSSRSYQPSCFRPSCG 177
NosR COG3901
Transcriptional regulator NosR of nitric oxide reductase [Transcription];
24-87 8.00e-03

Transcriptional regulator NosR of nitric oxide reductase [Transcription];


Pssm-ID: 443108 [Multi-domain]  Cd Length: 713  Bit Score: 35.68  E-value: 8.00e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907083510  24 CCVSSCCRPQCCQSVCCRPSCCRPSCCVSSCCRPQCCqsaCCQPTCCRPSCCRPSCCISSCCQP 87
Cdd:COG3901   603 FFFFRRLCLLGLALAAAALARRRLWRRRRRECCCGCC---CCCCKCCCIVIIIDGIIIINECCC 663
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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