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Conserved domains on  [gi|1907087525|ref|XP_036013296|]
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potassium voltage-gated channel subfamily H member 5 isoform X1 [Mus musculus]

Protein Classification

potassium voltage-gated channel protein; ion transporter( domain architecture ID 12140962)

potassium voltage-gated channel protein similar to members from Homo sapiens potassium voltage-gated channel subfamilies (F, G, and V)| ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium, across cell membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 217-479 3.35e-28

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 112.75  E-value: 3.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 217 WDWVILILTFYTAIMVPYNVSFKTKQ-NNIAWLVLDSVVDVIFLVDIVLNFHTTFvgpggevisdpklIRMNYLKT-WFV 294
Cdd:pfam00520   4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAG-------------FKKRYFRSpWNI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 295 IDLLSCLPYDIInaFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVL--VLLVCVFGLVAHWLACIWYSIGd 372
Cdd:pfam00520  71 LDFVVVLPSLIS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIrsLKSLGNLLLLLLLFLFIFAIIG- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 373 yevidevtntiqidswlYQLalsigtpyrYNTSAGIWEGGPSKDSL---YVSSLYFTMTSLTTIGFGNIAPTTDVEK--- 446
Cdd:pfam00520 148 -----------------YQL---------FGGKLKTWENPDNGRTNfdnFPNAFLWLFQTMTTEGWGDIMYDTIDGKgef 201

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1907087525 447 ----MFSVAMMMVGSLLYATIFGNVTTIFQQMYANTN 479
Cdd:pfam00520 202 wayiYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 39-132 2.43e-16

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 74.42  E-value: 2.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  39 PVVYSNDGFCKLSGYHRADVMQKSstCSFMYGELTDKKTIEKVRQTFDnyESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 118
Cdd:pfam13426   3 RIIYVNDAALRLLGYTREELLGKS--ITDLFAEPEDSERLREALREGK--AVREFEVVLYRKDGEPFPVLVSLAPIRDDG 78

                          90
                  ....*....|....
gi 1907087525 119 EKVVLFLCTFKDIT 132
Cdd:pfam13426  79 GELVGIIAILRDIT 92
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 217-479 3.35e-28

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 112.75  E-value: 3.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 217 WDWVILILTFYTAIMVPYNVSFKTKQ-NNIAWLVLDSVVDVIFLVDIVLNFHTTFvgpggevisdpklIRMNYLKT-WFV 294
Cdd:pfam00520   4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAG-------------FKKRYFRSpWNI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 295 IDLLSCLPYDIInaFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVL--VLLVCVFGLVAHWLACIWYSIGd 372
Cdd:pfam00520  71 LDFVVVLPSLIS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIrsLKSLGNLLLLLLLFLFIFAIIG- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 373 yevidevtntiqidswlYQLalsigtpyrYNTSAGIWEGGPSKDSL---YVSSLYFTMTSLTTIGFGNIAPTTDVEK--- 446
Cdd:pfam00520 148 -----------------YQL---------FGGKLKTWENPDNGRTNfdnFPNAFLWLFQTMTTEGWGDIMYDTIDGKgef 201

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1907087525 447 ----MFSVAMMMVGSLLYATIFGNVTTIFQQMYANTN 479
Cdd:pfam00520 202 wayiYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 217-509 3.64e-26

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 113.04  E-value: 3.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 217 WDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEV-ISDPKLIRMNYLKTWFVI 295
Cdd:PLN03192   64 WETLMVVLVAYSAWVYPFEVAFLNASPKRGLEIADNVVDLFFAVDIVLTFFVAYIDPRTQLlVRDRKKIAVRYLSTWFLM 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 296 DLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVAR-----KLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSI 370
Cdd:PLN03192  144 DVASTIPFQALAYLITGTVKLNLSYSLLGLLRFWRLRRVKQlftrlEKDIRFSYFWIRCARLLSVTLFLVHCAGCLYYLI 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 371 GDyevidevtntiqidswlyqlalsigtpyRYNTSAGIWEGG--PS--KDSL---YVSSLYFTMTSLTTIGFGNIAPTTD 443
Cdd:PLN03192  224 AD----------------------------RYPHQGKTWIGAviPNfrETSLwirYISAIYWSITTMTTVGYGDLHAVNT 275

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907087525 444 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQmyaNTNRYHEMLNNVR---DFLKLYQVPKGLSERVMDYI 509
Cdd:PLN03192  276 IEMIFIIFYMLFNLGLTAYLIGNMTNLVVE---GTRRTMEFRNSIEaasNFVGRNRLPPRLKDQILAYM 341
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 39-132 2.43e-16

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 74.42  E-value: 2.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  39 PVVYSNDGFCKLSGYHRADVMQKSstCSFMYGELTDKKTIEKVRQTFDnyESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 118
Cdd:pfam13426   3 RIIYVNDAALRLLGYTREELLGKS--ITDLFAEPEDSERLREALREGK--AVREFEVVLYRKDGEPFPVLVSLAPIRDDG 78

                          90
                  ....*....|....
gi 1907087525 119 EKVVLFLCTFKDIT 132
Cdd:pfam13426  79 GELVGIIAILRDIT 92
PAS COG2202
PAS domain [Signal transduction mechanisms];
37-136 6.75e-14

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 71.59  E-value: 6.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  37 DWPVVYSNDGFCKLSGYHRADVMQKssTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRN 116
Cdd:COG2202    30 DGRILYVNPAFERLTGYSAEELLGK--TLRDLLPPEDDDEFLELLRAALAGGGVWRGELRNRRKDGSLFWVELSISPVRD 107

                          90       100
                  ....*....|....*....|
gi 1907087525 117 EHEKVVLFLCTFKDITLFKQ 136
Cdd:COG2202   108 EDGEITGFVGIARDITERKR 127
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 37-132 4.12e-11

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 65.63  E-value: 4.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  37 DWPVVYSNDGFCKLSGYHRADVMQKSstCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRN 116
Cdd:PRK13558  170 DEPLIYINDAFERITGYSPDEVLGRN--CRFLQGEDTNEERVAELREAIDEERPTSVELRNYRKDGSTFWNQVDIAPIRD 247

                          90
                  ....*....|....*.
gi 1907087525 117 EHEKVVLFLCTFKDIT 132
Cdd:PRK13558  248 EDGTVTHYVGFQTDVT 263
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 37-131 7.36e-08

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 50.71  E-value: 7.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  37 DWPVVYSNDGFCKLSGYHRADVMQKSstcsfmYGELTDKKTIEKVRQTFDNYESN----CFEVLLYKKNRTPVWFYMQIA 112
Cdd:cd00130    11 DGRILYANPAAEQLLGYSPEELIGKS------LLDLIHPEDREELRERLENLLSGgepvTLEVRLRRKDGSVIWVLVSLT 84

                          90
                  ....*....|....*....
gi 1907087525 113 PIRNEHEKVVLFLCTFKDI 131
Cdd:cd00130    85 PIRDEGGEVIGLLGVVRDI 103
PAC smart00086
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif ...
 93-132 7.49e-06

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif occurs C-terminal to a subset of all known PAS motifs. It is proposed to contribute to the PAS domain fold.


Pssm-ID: 197509  Cd Length: 43  Bit Score: 42.94  E-value: 7.49e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907087525   93 FEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDIT 132
Cdd:smart00086   2 VEYRLRRKDGSYIWVLVSASPIRDEDGEVEGILGVVRDIT 41
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 14-132 1.42e-03

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 38.81  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  14 TFLENIVRRSSESSFLLG-NAQIVDWpvvysNDGFCKLSGYHRADVMQKSSTcSFMYGELTDK--KTIEKVRQTFDNYES 90
Cdd:TIGR00229   3 ERYRAIFESSPDAIIVIDlEGNILYV-----NPAFEEIFGYSAEELIGRNVL-ELIPEEDREEvrERIERRLEGEPEPVS 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1907087525  91 NCFEVllYKKNRTPVWFYMQIAPIRnEHEKVVLFLCTFKDIT 132
Cdd:TIGR00229  77 EERRV--RRKDGSEIWVEVSVSPIR-TNGGELGVVGIVRDIT 115
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 217-479 3.35e-28

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 112.75  E-value: 3.35e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 217 WDWVILILTFYTAIMVPYNVSFKTKQ-NNIAWLVLDSVVDVIFLVDIVLNFHTTFvgpggevisdpklIRMNYLKT-WFV 294
Cdd:pfam00520   4 FELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAG-------------FKKRYFRSpWNI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 295 IDLLSCLPYDIInaFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVL--VLLVCVFGLVAHWLACIWYSIGd 372
Cdd:pfam00520  71 LDFVVVLPSLIS--LVLSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIrsLKSLGNLLLLLLLFLFIFAIIG- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 373 yevidevtntiqidswlYQLalsigtpyrYNTSAGIWEGGPSKDSL---YVSSLYFTMTSLTTIGFGNIAPTTDVEK--- 446
Cdd:pfam00520 148 -----------------YQL---------FGGKLKTWENPDNGRTNfdnFPNAFLWLFQTMTTEGWGDIMYDTIDGKgef 201

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1907087525 447 ----MFSVAMMMVGSLLYATIFGNVTTIFQQMYANTN 479
Cdd:pfam00520 202 wayiYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 217-509 3.64e-26

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 113.04  E-value: 3.64e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 217 WDWVILILTFYTAIMVPYNVSFKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEV-ISDPKLIRMNYLKTWFVI 295
Cdd:PLN03192   64 WETLMVVLVAYSAWVYPFEVAFLNASPKRGLEIADNVVDLFFAVDIVLTFFVAYIDPRTQLlVRDRKKIAVRYLSTWFLM 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 296 DLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVAR-----KLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSI 370
Cdd:PLN03192  144 DVASTIPFQALAYLITGTVKLNLSYSLLGLLRFWRLRRVKQlftrlEKDIRFSYFWIRCARLLSVTLFLVHCAGCLYYLI 223

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525 371 GDyevidevtntiqidswlyqlalsigtpyRYNTSAGIWEGG--PS--KDSL---YVSSLYFTMTSLTTIGFGNIAPTTD 443
Cdd:PLN03192  224 AD----------------------------RYPHQGKTWIGAviPNfrETSLwirYISAIYWSITTMTTVGYGDLHAVNT 275

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907087525 444 VEKMFSVAMMMVGSLLYATIFGNVTTIFQQmyaNTNRYHEMLNNVR---DFLKLYQVPKGLSERVMDYI 509
Cdd:PLN03192  276 IEMIFIIFYMLFNLGLTAYLIGNMTNLVVE---GTRRTMEFRNSIEaasNFVGRNRLPPRLKDQILAYM 341
PAS_9 pfam13426
PAS domain; This domain is found in many signalling proteins in which it functions as a sensor ...
 39-132 2.43e-16

PAS domain; This domain is found in many signalling proteins in which it functions as a sensor domain. It recognizes FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 463873 [Multi-domain]  Cd Length: 93  Bit Score: 74.42  E-value: 2.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  39 PVVYSNDGFCKLSGYHRADVMQKSstCSFMYGELTDKKTIEKVRQTFDnyESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 118
Cdd:pfam13426   3 RIIYVNDAALRLLGYTREELLGKS--ITDLFAEPEDSERLREALREGK--AVREFEVVLYRKDGEPFPVLVSLAPIRDDG 78

                          90
                  ....*....|....
gi 1907087525 119 EKVVLFLCTFKDIT 132
Cdd:pfam13426  79 GELVGIIAILRDIT 92
PAS COG2202
PAS domain [Signal transduction mechanisms];
37-136 6.75e-14

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 71.59  E-value: 6.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  37 DWPVVYSNDGFCKLSGYHRADVMQKssTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRN 116
Cdd:COG2202    30 DGRILYVNPAFERLTGYSAEELLGK--TLRDLLPPEDDDEFLELLRAALAGGGVWRGELRNRRKDGSLFWVELSISPVRD 107

                          90       100
                  ....*....|....*....|
gi 1907087525 117 EHEKVVLFLCTFKDITLFKQ 136
Cdd:COG2202   108 EDGEITGFVGIARDITERKR 127
PRK13558 PRK13558
bacterio-opsin activator; Provisional
 37-132 4.12e-11

bacterio-opsin activator; Provisional


Pssm-ID: 237426 [Multi-domain]  Cd Length: 665  Bit Score: 65.63  E-value: 4.12e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  37 DWPVVYSNDGFCKLSGYHRADVMQKSstCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRN 116
Cdd:PRK13558  170 DEPLIYINDAFERITGYSPDEVLGRN--CRFLQGEDTNEERVAELREAIDEERPTSVELRNYRKDGSTFWNQVDIAPIRD 247

                          90
                  ....*....|....*.
gi 1907087525 117 EHEKVVLFLCTFKDIT 132
Cdd:PRK13558  248 EDGTVTHYVGFQTDVT 263
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 419-473 4.99e-10

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 55.74  E-value: 4.99e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907087525 419 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQ 473
Cdd:pfam07885  24 FLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
PRK13557 PRK13557
histidine kinase; Provisional
 37-132 6.35e-09

histidine kinase; Provisional


Pssm-ID: 237425 [Multi-domain]  Cd Length: 540  Bit Score: 58.53  E-value: 6.35e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  37 DWPVVYSNDGFCKLSGYHRADVMqkSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRN 116
Cdd:PRK13557   52 DNPIVFANRAFLEMTGYAAEEII--GNNCRFLQGPETDRATVAEVRDAIAERREIATEILNYRKDGSSFWNALFVSPVYN 129

                          90
                  ....*....|....*.
gi 1907087525 117 EHEKVVLFLCTFKDIT 132
Cdd:PRK13557  130 DAGDLVYFFGSQLDVS 145
PRK13559 PRK13559
hypothetical protein; Provisional
 37-132 2.63e-08

hypothetical protein; Provisional


Pssm-ID: 237427 [Multi-domain]  Cd Length: 361  Bit Score: 55.98  E-value: 2.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  37 DWPVVYSNDGFCKLSGYHRADVMQKSstCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRN 116
Cdd:PRK13559   65 DLPIVLANQAFLDLTGYAAEEVVGRN--CRFLQGAATDPIAVAKIRAAIAAEREIVVELLNYRKDGEPFWNALHLGPVYG 142

                          90
                  ....*....|....*.
gi 1907087525 117 EHEKVVLFLCTFKDIT 132
Cdd:PRK13559  143 EDGRLLYFFGSQWDVT 158
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 37-131 7.36e-08

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 50.71  E-value: 7.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  37 DWPVVYSNDGFCKLSGYHRADVMQKSstcsfmYGELTDKKTIEKVRQTFDNYESN----CFEVLLYKKNRTPVWFYMQIA 112
Cdd:cd00130    11 DGRILYANPAAEQLLGYSPEELIGKS------LLDLIHPEDREELRERLENLLSGgepvTLEVRLRRKDGSVIWVLVSLT 84

                          90
                  ....*....|....*....
gi 1907087525 113 PIRNEHEKVVLFLCTFKDI 131
Cdd:cd00130    85 PIRDEGGEVIGLLGVVRDI 103
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 40-131 1.38e-06

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 47.03  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  40 VVYSNDGFCKLSGYHRADVMQKS-STCSFMYGELTDKKTIEKVRQTFDnyESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 118
Cdd:pfam00989  23 ILYVNAAAEELLGLSREEVIGKSlLDLIPEEDDAEVAELLRQALLQGE--ESRGFEVSFRVPDGRPRHVEVRASPVRDAG 100

                          90
                  ....*....|...
gi 1907087525 119 EKVVLFLCTFKDI 131
Cdd:pfam00989 101 GEILGFLGVLRDI 113
PAC smart00086
Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif ...
 93-132 7.49e-06

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); PAC motif occurs C-terminal to a subset of all known PAS motifs. It is proposed to contribute to the PAS domain fold.


Pssm-ID: 197509  Cd Length: 43  Bit Score: 42.94  E-value: 7.49e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907087525   93 FEVLLYKKNRTPVWFYMQIAPIRNEHEKVVLFLCTFKDIT 132
Cdd:smart00086   2 VEYRLRRKDGSYIWVLVSASPIRDEDGEVEGILGVVRDIT 41
PRK10537 PRK10537
voltage-gated potassium channel protein;
420-467 2.17e-04

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 43.86  E-value: 2.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1907087525 420 VSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYAT----IFGNV 467
Cdd:PRK10537  170 STAFYFSIVTMSTVGYGDIVPVSESARLFTISVIILGITVFATsisaIFGPV 221
NtrB COG3852
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
40-136 2.60e-04

Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];


Pssm-ID: 443061 [Multi-domain]  Cd Length: 361  Bit Score: 43.30  E-value: 2.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  40 VVYSNDGFCKLSGYHRADVMQKSSTCSFMYGELtDKKTIEKVRQTfdNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHE 119
Cdd:COG3852    29 ITYVNPAAERLLGLSAEELLGRPLAELFPEDSP-LRELLERALAE--GQPVTEREVTLRRKDGEERPVDVSVSPLRDAEG 105

                          90
                  ....*....|....*..
gi 1907087525 120 KvVLFLCTFKDITLFKQ 136
Cdd:COG3852   106 E-GGVLLVLRDITERKR 121
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 40-127 1.17e-03

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 38.09  E-value: 1.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  40 VVYSNDGFCKLSGYHRADVMQKSSTC-SFMYGEltDkktIEKVRQTFDNYESN----CFEVLLYKKNRTPVWFYMQIAPI 114
Cdd:pfam08447   1 IIYWSPRFEEILGYTPEELLGKGESWlDLVHPD--D---RERVREALWEALKGgepySGEYRIRRKDGEYRWVEARARPI 75

                          90
                  ....*....|...
gi 1907087525 115 RNEHEKVVLFLCT 127
Cdd:pfam08447  76 RDENGKPVRVIGV 88
sensory_box TIGR00229
PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain ...
 14-132 1.42e-03

PAS domain S-box; The PAS domain was previously described. This sensory box, or S-box domain occupies the central portion of the PAS domain but is more widely distributed. It is often tandemly repeated. Known prosthetic groups bound in the S-box domain include heme in the oxygen sensor FixL, FAD in the redox potential sensor NifL, and a 4-hydroxycinnamyl chromophore in photoactive yellow protein. Proteins containing the domain often contain other regulatory domains such as response regulator or sensor histidine kinase domains. Other S-box proteins include phytochromes and the aryl hydrocarbon receptor nuclear translocator. [Regulatory functions, Small molecule interactions]


Pssm-ID: 272971 [Multi-domain]  Cd Length: 124  Bit Score: 38.81  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  14 TFLENIVRRSSESSFLLG-NAQIVDWpvvysNDGFCKLSGYHRADVMQKSSTcSFMYGELTDK--KTIEKVRQTFDNYES 90
Cdd:TIGR00229   3 ERYRAIFESSPDAIIVIDlEGNILYV-----NPAFEEIFGYSAEELIGRNVL-ELIPEEDREEvrERIERRLEGEPEPVS 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1907087525  91 NCFEVllYKKNRTPVWFYMQIAPIRnEHEKVVLFLCTFKDIT 132
Cdd:TIGR00229  77 EERRV--RRKDGSEIWVEVSVSPIR-TNGGELGVVGIVRDIT 115
PAS COG2202
PAS domain [Signal transduction mechanisms];
40-136 1.93e-03

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 40.39  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907087525  40 VVYSNDGFCKLSGYHRADVMQKSSTcsfmygELTDKKTIEKVRQTFDN-----YESNCFEVLLYKKNRTPVWFYMQIAPI 114
Cdd:COG2202   159 ILYVNPAAEELLGYSPEELLGKSLL------DLLHPEDRERLLELLRRlleggRESYELELRLKDGDGRWVWVEASAVPL 232

                          90       100
                  ....*....|....*....|..
gi 1907087525 115 RNEHEkVVLFLCTFKDITLFKQ 136
Cdd:COG2202   233 RDGGE-VIGVLGIVRDITERKR 253
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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