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Conserved domains on  [gi|1907089883|ref|XP_036013598|]
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striatin-3 isoform X2 [Mus musculus]

Protein Classification

striatin( domain architecture ID 10548818)

striatin, a WD40 repeat protein which may function as scaffolding or signaling protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-805 5.79e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 212.97  E-value: 5.79e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 484 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 563
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 564 ATIQWWNmpspnvdpydtYESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCVCTYNGdKEHGIp 643
Cdd:cd00200    73 KTIRLWD-----------LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 644 TSVDFIGCDpaHMVTSF-NTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 722
Cdd:cd00200   139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 723 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 802
Cdd:cd00200   210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                  ...
gi 1907089883 803 KVF 805
Cdd:cd00200   286 RIW 288
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-190 3.29e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


:

Pssm-ID: 462401  Cd Length: 85  Bit Score: 156.51  E-value: 3.29e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883  65 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907089883 145 dlkmptfeseetkdveappapqnsqlTWKQGRQLLRQYLQEVGYTD 190
Cdd:pfam08232  66 --------------------------KRKKSRQYLKKCLQEIGYLD 85
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-805 5.79e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 212.97  E-value: 5.79e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 484 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 563
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 564 ATIQWWNmpspnvdpydtYESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCVCTYNGdKEHGIp 643
Cdd:cd00200    73 KTIRLWD-----------LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 644 TSVDFIGCDpaHMVTSF-NTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 722
Cdd:cd00200   139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 723 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 802
Cdd:cd00200   210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                  ...
gi 1907089883 803 KVF 805
Cdd:cd00200   286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
444-804 7.42e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.83  E-value: 7.42e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 444 LLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWN-----PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 518
Cdd:COG2319    70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlatglLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 519 QKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNvdpydtyesnvLAGTLVAHTDAV 598
Cdd:COG2319   150 ATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAV 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 599 WGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCVCTYNGDkeHGIPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSL 676
Cdd:COG2319   208 RSVAFSpdG--KLLASGSADGTVRLWDLATG-KLLRTLTGH--SGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELL 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 677 VMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 756
Cdd:COG2319   282 RTLTGHSGG-------VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1907089883 757 RLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKV 804
Cdd:COG2319   355 RLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-190 3.29e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 156.51  E-value: 3.29e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883  65 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907089883 145 dlkmptfeseetkdveappapqnsqlTWKQGRQLLRQYLQEVGYTD 190
Cdd:pfam08232  66 --------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 721-760 6.79e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 6.79e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907089883  721 TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 760
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
722-760 1.13e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 1.13e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907089883 722 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 760
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-805 5.79e-63

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 212.97  E-value: 5.79e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 484 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQktvpakksaslDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 563
Cdd:cd00200     4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE-----------TGELLRTLKGHTGPVRDVAASADGTYLASGSSD 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 564 ATIQWWNmpspnvdpydtYESNVLAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNPqEKLPCVCTYNGdKEHGIp 643
Cdd:cd00200    73 KTIRLWD-----------LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV-ETGKCLTTLRG-HTDWV- 138

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 644 TSVDFIGCDpaHMVTSF-NTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTG 722
Cdd:cd00200   139 NSVAFSPDG--TFVASSsQDGTIKLWDLRTGKCVATLTGHTGE-------VNSVAFSPDGEKLLSSSSDGTIKLWDLSTG 209

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 723 KMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALA 802
Cdd:cd00200   210 KCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH----TNSVTSLAWSPDGKRLASGSADGTI 285


                  ...
gi 1907089883 803 KVF 805
Cdd:cd00200   286 RIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
444-804 7.42e-58

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 202.83  E-value: 7.42e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 444 LLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWN-----PKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNL 518
Cdd:COG2319    70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDlatglLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 519 QKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPNvdpydtyesnvLAGTLVAHTDAV 598
Cdd:COG2319   150 ATG-----------KLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGK-----------LLRTLTGHTGAV 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 599 WGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCVCTYNGDkeHGIPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSL 676
Cdd:COG2319   208 RSVAFSpdG--KLLASGSADGTVRLWDLATG-KLLRTLTGH--SGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELL 281

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 677 VMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSI 756
Cdd:COG2319   282 RTLTGHSGG-------VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTV 354

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 1907089883 757 RLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKV 804
Cdd:COG2319   355 RLWDLATGELLRTLTGH----TGAVTSVAFSPDGRTLASGSADGTVRL 398
Striatin pfam08232
Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a ...
 65-190 3.29e-45

Striatin family; Striatin is an intracellular protein which has a caveolin-binding motif, a coiled-coil structure, a calmodulin-binding site, and a WD (pfam00400) repeat domain. It acts as a scaffold protein and is involved in signalling pathways.


Pssm-ID: 462401  Cd Length: 85  Bit Score: 156.51  E-value: 3.29e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883  65 IPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERakyhklkygtelnqg 144
Cdd:pfam08232   1 LPGVLHFLQTEWHRHERDRNAWEIERAEMKARIAKLEGERRGQENLKKDLKRRIKMLEYALKQES--------------- 65

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1907089883 145 dlkmptfeseetkdveappapqnsqlTWKQGRQLLRQYLQEVGYTD 190
Cdd:pfam08232  66 --------------------------KRKKSRQYLKKCLQEIGYLD 85
WD40 COG2319
WD40 repeat [General function prediction only];
477-763 9.94e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.24  E-value: 9.94e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 477 KTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQ 556
Cdd:COG2319   150 ATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG-----------KLLRTLTGHTGAVRSVAFSPDGKL 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 557 CFSGGIDATIQWWNMpspnvdpydtyESNVLAGTLVAHTDAVWGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCVCTY 634
Cdd:COG2319   219 LASGSADGTVRLWDL-----------ATGKLLRTLTGHSGSVRSVAFSpdG--RLLASGSADGTVRLWDLATG-ELLRTL 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 635 NGDkeHGIPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSLVMLSSQVDSglqssnhINRVVSHPTLPVTITAHEDRHI 714
Cdd:COG2319   285 TGH--SGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-------VRSVAFSPDGKTLASGSDDGTV 354

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1907089883 715 KFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDS 763
Cdd:COG2319   355 RLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
484-805 7.89e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.99  E-value: 7.89e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 484 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTvpakksasldvEPIYTFRAHIGPVLSLAISSNGEQCFSGGID 563
Cdd:COG2319    31 LLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAG-----------ALLATLLGHTAAVLSVAFSPDGRLLASASAD 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 564 ATIQWWNMpspnvdpydtyESNVLAGTLVAHTDAVWGLAYS--GikNQLLSCSADGTIRLWNPQEKlPCVCTYNGDkeHG 641
Cdd:COG2319   100 GTVRLWDL-----------ATGLLLRTLTGHTGAVRSVAFSpdG--KTLASGSADGTVRLWDLATG-KLLRTLTGH--SG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 642 IPTSVDFIGcDPAHMVTSFNTGSAVIYDLETSQSLVMLSSqvdsglqSSNHINRVVSHP---TLpvtITAHEDRHIKFFD 718
Cdd:COG2319   164 AVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG-------HTGAVRSVAFSPdgkLL---ASGSADGTVRLWD 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 719 NKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGA 798
Cdd:COG2319   233 LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGH----SGGVNSVAFSPDGKLLASGSD 308


                  ....*..
gi 1907089883 799 DALAKVF 805
Cdd:COG2319   309 DGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 587-805 1.12e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 128.22  E-value: 1.12e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 587 LAGTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWNpQEKLPCVCTYngdKEHGIP-TSVDFIGCDPAhMVTSFNTGSA 665
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD-LETGELLRTL---KGHTGPvRDVAASADGTY-LASGSSDKTI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907089883 666 VIYDLETSQSLVMLSSqvdsglqssnHINRVVS---HPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDP 742
Cdd:cd00200    76 RLWDLETGECVRTLTG----------HTSYVSSvafSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP 145

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907089883 743 NGIYLMSGSHDCSIRLWNLDSKTCVQEITAHrkklDESIYDVAFHPSKAYIASAGADALAKVF 805
Cdd:cd00200   146 DGTFVASSSQDGTIKLWDLRTGKCVATLTGH----TGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 721-760 6.79e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 6.79e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907089883  721 TGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 760
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
722-760 1.13e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.19  E-value: 1.13e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907089883 722 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWN 760
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 478-517 1.92e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 50.77  E-value: 1.92e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1907089883  478 TWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN 517
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
479-517 8.37e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 48.88  E-value: 8.37e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1907089883 479 WNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWN 517
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 590-623 1.79e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.79e-07
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1907089883  590 TLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWN 623
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
476-519 8.95e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.22  E-value: 8.95e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1907089883 476 RKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQ 519
Cdd:COG2319   359 LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 pfam00400
WD domain, G-beta repeat;
589-623 9.23e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 9.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907089883 589 GTLVAHTDAVWGLAYSGIKNQLLSCSADGTIRLWN 623
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 533-570 1.56e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.38  E-value: 1.56e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1907089883  533 EPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN 570
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
533-570 1.24e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 1.24e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1907089883 533 EPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWN 570
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 763-805 9.27e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 9.27e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1907089883  763 SKTCVQEITAHRKkldeSIYDVAFHPSKAYIASAGADALAKVF 805
Cdd:smart00320   1 SGELLKTLKGHTG----PVTSVAFSPDGKYLASGSDDGTIKLW 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 722-787 5.57e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 39.67  E-value: 5.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1907089883 722 GKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNL--------DSKTCVQEItaHRKklDESIYDVAFH 787
Cdd:pfam20426 114 GRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVlrgrssekRSRNTQTEF--PRK--DHVIAETPFH 183
WD40 pfam00400
WD domain, G-beta repeat;
764-805 5.99e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.01  E-value: 5.99e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1907089883 764 KTCVQEITAHRKkldeSIYDVAFHPSKAYIASAGADALAKVF 805
Cdd:pfam00400   1 GKLLKTLEGHTG----SVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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