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Conserved domains on  [gi|1907092119|ref|XP_036013726|]
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protein DEK isoform X1 [Mus musculus]

Protein Classification

SAP domain-containing protein( domain architecture ID 10649971)

SAP (SAF-A/B, Acinus and PIAS) domain-containing protein may bind DNA or RNA and act as a transcriptional regulator

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DEK_C pfam08766
DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and ...
 325-379 1.61e-14

DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteriztic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. The structure of this domain shows it to be homologous to the E2F/DP transcription factor family. This domain is also found in chitin synthase proteins like Swiss:Q8TF96, and in protein phosphatases such as Swiss:Q6NN85.


:

Pssm-ID: 462592  Cd Length: 54  Bit Score: 67.41  E-value: 1.61e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907092119 325 PTDEELKETVKKLLADANLEEVTMKQICKEVYENYPaYDLTERKDFIKTTVKELI 379
Cdd:pfam08766   1 PTDEEIREAIREILRTADLETVTKKQVRKQLEERLG-VDLSERKAFINALIDEIL 54
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
153-187 1.59e-05

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


:

Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 41.32  E-value: 1.59e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907092119  153 LKKFRNAMLKSICEVLDLERSGVNSELVKRILNFL 187
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
 
Name Accession Description Interval E-value
DEK_C pfam08766
DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and ...
 325-379 1.61e-14

DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteriztic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. The structure of this domain shows it to be homologous to the E2F/DP transcription factor family. This domain is also found in chitin synthase proteins like Swiss:Q8TF96, and in protein phosphatases such as Swiss:Q6NN85.


Pssm-ID: 462592  Cd Length: 54  Bit Score: 67.41  E-value: 1.61e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907092119 325 PTDEELKETVKKLLADANLEEVTMKQICKEVYENYPaYDLTERKDFIKTTVKELI 379
Cdd:pfam08766   1 PTDEEIREAIREILRTADLETVTKKQVRKQLEERLG-VDLSERKAFINALIDEIL 54
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
153-187 1.59e-05

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 41.32  E-value: 1.59e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907092119  153 LKKFRNAMLKSICEVLDLERSGVNSELVKRILNFL 187
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 153-187 1.89e-03

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 35.45  E-value: 1.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907092119 153 LKKFRNAMLKSICEVLDLERSGVNSELVKRILNFL 187
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
 
Name Accession Description Interval E-value
DEK_C pfam08766
DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and ...
 325-379 1.61e-14

DEK C terminal domain; DEK is a chromatin associated protein that is linked with cancers and autoimmune disease. This domain is found at the C terminal of DEK and is of clinical importance since it can reverse the characteriztic abnormal DNA-mutagen sensitivity in fibroblasts from ataxia-telangiectasia (A-T) patients. The structure of this domain shows it to be homologous to the E2F/DP transcription factor family. This domain is also found in chitin synthase proteins like Swiss:Q8TF96, and in protein phosphatases such as Swiss:Q6NN85.


Pssm-ID: 462592  Cd Length: 54  Bit Score: 67.41  E-value: 1.61e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1907092119 325 PTDEELKETVKKLLADANLEEVTMKQICKEVYENYPaYDLTERKDFIKTTVKELI 379
Cdd:pfam08766   1 PTDEEIREAIREILRTADLETVTKKQVRKQLEERLG-VDLSERKAFINALIDEIL 54
SAP smart00513
Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;
153-187 1.59e-05

Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation;


Pssm-ID: 128789 [Multi-domain]  Cd Length: 35  Bit Score: 41.32  E-value: 1.59e-05
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1907092119  153 LKKFRNAMLKSICEVLDLERSGVNSELVKRILNFL 187
Cdd:smart00513   1 LAKLKVSELKDELKKRGLSTSGTKAELVDRLLEAL 35
SAP pfam02037
SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding ...
 153-187 1.89e-03

SAP domain; The SAP (after SAF-A/B, Acinus and PIAS) motif is a putative DNA/RNA binding domain found in diverse nuclear and cytoplasmic proteins.


Pssm-ID: 460424 [Multi-domain]  Cd Length: 35  Bit Score: 35.45  E-value: 1.89e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1907092119 153 LKKFRNAMLKSICEVLDLERSGVNSELVKRILNFL 187
Cdd:pfam02037   1 LSKLTVAELKEELRKRGLPTSGKKAELIERLQEYL 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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