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Conserved domains on  [gi|1907093815|ref|XP_036013953|]
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DNA polymerase kappa isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 103-433 8.65e-142

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


:

Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 420.00  E-value: 8.65e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 179
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 180 VKEILAEYDPNFMAMSLDEAYLNITQHLQERQDwPED-----KRRYFIKMGnyLK--IGIAPNTMLAKVCSDKNKPNGQY 252
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLFGS-ATEiakeiRARIREETG--LTasAGIAPNKFLAKIASDLNKPNGLT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 253 QILPsrSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSWHYFLHIALGLGSTDLARDGER 332
Cdd:cd03586   158 VIPP--EDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRER 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 333 KSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELL 411
Cdd:cd03586   236 KSIGVERTFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELL 315

                         330       340
                  ....*....|....*....|..
gi 1907093815 412 RTEvnvgsPHPLRLRLMGVRMS 433
Cdd:cd03586   316 EEL-----LDGRPIRLLGVRLS 332
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 540-565 2.04e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 41.82  E-value: 2.04e-05
                           10        20
                   ....*....|....*....|....*.
gi 1907093815  540 FICPVCFREqegVSLEAFNEHVDECL 565
Cdd:smart00734   2 VQCPVCFRE---VPENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 681-707 6.31e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


:

Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 40.28  E-value: 6.31e-05
                           10        20
                   ....*....|....*....|....*..
gi 1907093815  681 ALVCPVCNLEQetsDLTLFNIHVDICL 707
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 103-433 8.65e-142

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 420.00  E-value: 8.65e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 179
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 180 VKEILAEYDPNFMAMSLDEAYLNITQHLQERQDwPED-----KRRYFIKMGnyLK--IGIAPNTMLAKVCSDKNKPNGQY 252
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLFGS-ATEiakeiRARIREETG--LTasAGIAPNKFLAKIASDLNKPNGLT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 253 QILPsrSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSWHYFLHIALGLGSTDLARDGER 332
Cdd:cd03586   158 VIPP--EDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRER 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 333 KSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELL 411
Cdd:cd03586   236 KSIGVERTFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELL 315

                         330       340
                  ....*....|....*....|..
gi 1907093815 412 RTEvnvgsPHPLRLRLMGVRMS 433
Cdd:cd03586   316 EEL-----LDGRPIRLLGVRLS 332
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 101-433 1.31e-99

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 311.31  E-value: 1.31e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 177
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 178 KEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQDWPEdkrryfikMGNYLK------------IGIAPNTMLAKVCSDK 245
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEA--------IARRIRrrirretgltvsVGIAPNKFLAKIASDL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 246 NKPNGQYQILPSRsaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ-RALLSLLFSEtSWHYFLHIALGLGST 324
Cdd:COG0389   154 AKPDGLTVIPPGE--VAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPR 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 325 DLARDGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEI 403
Cdd:COG0389   231 PVEPRRPRKSIGVERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAEL 310

                         330       340       350
                  ....*....|....*....|....*....|
gi 1907093815 404 FAIAKELLRTEVNVGSPhplrLRLMGVRMS 433
Cdd:COG0389   311 LRAARELLERIYRPGRP----VRLLGVRLS 336
PRK02406 PRK02406
DNA polymerase IV; Validated
 107-441 2.31e-98

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 308.20  E-value: 2.31e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 107 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 182
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 183 ILAEYDPNFMAMSLDEAYLNITQHL----------QE-RQD-WPEdkrryfikmgnyLKI----GIAPNTMLAKVCSDKN 246
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVTDNKlcigsatliaQEiRQDiFEE------------LGLtasaGVAPNKFLAKIASDWN 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 247 KPNGQYQILPSRsaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELyQQRALLSLLfsetswHYF------LHialg 320
Cdd:PRK02406  149 KPNGLFVITPEE--VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELI------RHFgkfgrrLY---- 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 321 lgstDLAR---------DGERKSMSVERTFSEISKTEEQyslCQE----LCAELAHDLQKEG--LKGRTVTIKLKNVNFE 385
Cdd:PRK02406  216 ----ERARgiderpvkpDRERKSVGVERTFAEDLYDLEA---CLAelprLAEKLERRLERAKpdKRIKTVGVKLKFADFQ 288

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907093815 386 VKTRaSTVPAAISTAEEIFAIAKELLRTEVNVGsphplrLRLMGVRMSTFSSEDDR 441
Cdd:PRK02406  289 QTTK-EHTADPLDKADLIELLAQALLRRLGGRG------VRLLGVGVTLLEPQLER 337
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 105-244 4.61e-48

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 166.60  E-value: 4.61e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 105 VDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 181
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093815 182 EILAEY-DPNFMAMSLDEAYLNITqHLQERQDWPED-----KRRYFIKMGNYLKIGIAPNTMLAKVCSD 244
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLT-GLEKLFGAEEAlakrlRREIAEETGLTCSIGIAPNKLLAKLASD 148
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 540-565 2.04e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 41.82  E-value: 2.04e-05
                           10        20
                   ....*....|....*....|....*.
gi 1907093815  540 FICPVCFREqegVSLEAFNEHVDECL 565
Cdd:smart00734   2 VQCPVCFRE---VPENLINSHLDSCL 24
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 681-707 6.31e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 40.28  E-value: 6.31e-05
                           10        20
                   ....*....|....*....|....*..
gi 1907093815  681 ALVCPVCNLEQetsDLTLFNIHVDICL 707
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
 
Name Accession Description Interval E-value
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 103-433 8.65e-142

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 420.00  E-value: 8.65e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE 179
Cdd:cd03586     1 IHIDMDAFYASVEQRDNPELKGKPVAVGGSSdrgVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPPRFDKYREVSRQ 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 180 VKEILAEYDPNFMAMSLDEAYLNITQHLQERQDwPED-----KRRYFIKMGnyLK--IGIAPNTMLAKVCSDKNKPNGQY 252
Cdd:cd03586    81 IMEILREYTPLVEPLSIDEAYLDVTDYVRLFGS-ATEiakeiRARIREETG--LTasAGIAPNKFLAKIASDLNKPNGLT 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 253 QILPsrSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSWHYFLHIALGLGSTDLARDGER 332
Cdd:cd03586   158 VIPP--EDVEEFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEPDRER 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 333 KSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELL 411
Cdd:cd03586   236 KSIGVERTFSEdLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFSTRTRSRTLPEPTDDAEDIYELALELL 315

                         330       340
                  ....*....|....*....|..
gi 1907093815 412 RTEvnvgsPHPLRLRLMGVRMS 433
Cdd:cd03586   316 EEL-----LDGRPIRLLGVRLS 332
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 101-433 1.31e-99

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 311.31  E-value: 1.31e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSM---LATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVS 177
Cdd:COG0389     2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGDNNrgvVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPPDFELYRDVS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 178 KEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQDWPEdkrryfikMGNYLK------------IGIAPNTMLAKVCSDK 245
Cdd:COG0389    82 RRVMAILERYTPLVEPLSIDEAFLDVTGSARLFGSAEA--------IARRIRrrirretgltvsVGIAPNKFLAKIASDL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 246 NKPNGQYQILPSRsaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ-RALLSLLFSEtSWHYFLHIALGLGST 324
Cdd:COG0389   154 AKPDGLTVIPPGE--VAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALpRAELRRRFGK-VGERLYRLARGIDPR 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 325 DLARDGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEI 403
Cdd:COG0389   231 PVEPRRPRKSIGVERTFGEdLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRTTTRSRTLPEPTDDTAEL 310

                         330       340       350
                  ....*....|....*....|....*....|
gi 1907093815 404 FAIAKELLRTEVNVGSPhplrLRLMGVRMS 433
Cdd:COG0389   311 LRAARELLERIYRPGRP----VRLLGVRLS 336
PRK02406 PRK02406
DNA polymerase IV; Validated
 107-441 2.31e-98

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 308.20  E-value: 2.31e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 107 MDAFYAAVEMRDNPELKDKPIAVGS----MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKE 182
Cdd:PRK02406    1 MDCFYAAVEMRDNPELRGKPVAVGGspgrRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPGRFDVYKEVSRQIRE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 183 ILAEYDPNFMAMSLDEAYLNITQHL----------QE-RQD-WPEdkrryfikmgnyLKI----GIAPNTMLAKVCSDKN 246
Cdd:PRK02406   81 IFRRYTDLIEPLSLDEAYLDVTDNKlcigsatliaQEiRQDiFEE------------LGLtasaGVAPNKFLAKIASDWN 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 247 KPNGQYQILPSRsaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELyQQRALLSLLfsetswHYF------LHialg 320
Cdd:PRK02406  149 KPNGLFVITPEE--VDAFLATLPVEKIPGVGKVTAEKLHALGIYTCADL-QKYDLAELI------RHFgkfgrrLY---- 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 321 lgstDLAR---------DGERKSMSVERTFSEISKTEEQyslCQE----LCAELAHDLQKEG--LKGRTVTIKLKNVNFE 385
Cdd:PRK02406  216 ----ERARgiderpvkpDRERKSVGVERTFAEDLYDLEA---CLAelprLAEKLERRLERAKpdKRIKTVGVKLKFADFQ 288

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1907093815 386 VKTRaSTVPAAISTAEEIFAIAKELLRTEVNVGsphplrLRLMGVRMSTFSSEDDR 441
Cdd:PRK02406  289 QTTK-EHTADPLDKADLIELLAQALLRRLGGRG------VRLLGVGVTLLEPQLER 337
PTZ00205 PTZ00205
DNA polymerase kappa; Provisional
 16-457 1.62e-82

DNA polymerase kappa; Provisional


Pssm-ID: 140232 [Multi-domain]  Cd Length: 571  Bit Score: 274.20  E-value: 1.62e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815  16 LRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQVNQRIENMMQQKAQIT--------SQQLRKAQLQVDK 87
Cdd:PTZ00205   42 FQLTLDCNKAGMGNVDKERVEAIIRNVSEGSSFLMNEQRLAEGREKQLQELKRKSSLFTqllggernAAQRKQWELKVSK 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815  88 FAMELERNRNLNnTIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVP 167
Cdd:PTZ00205  122 IEQELEATRRLG-TYIHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILP 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 168 PNFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQ--ERQDWPED-----KRRYFIKMGNYLKIGIAPNTMLAK 240
Cdd:PTZ00205  201 PDFDAYNEESNTVRRIVAEYDPNYISFGLDELTLEVSAYIErfEGTKTAEDvaselRVRVFGETKLTASAGIGPTAALAK 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 241 VCSDKNKPNGQYQI-LPSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQRALLSLLFSETSWHYFLHIAL 319
Cdd:PTZ00205  281 IASNINKPNGQHDLnLHTRGDVMTYVRDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCYILHNNLFRFLLGASI 360

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 320 GL------------GSTDLARDGERKSMSVERTFSEISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVK 387
Cdd:PTZ00205  361 GImqwpdaataantENCEGATGGQRKAISSERSFTTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASYRYQ 440

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907093815 388 TRASTVPAAISTAEEIFAIAKELLRtevnvgsPHPLR---LRLMGVRMSTFSSEDDRkHQQRsiigflQAGNQ 457
Cdd:PTZ00205  441 QYTKSLIQYSDDSATLRRAVDGLLL-------PHAAKyseMCLLGVRFLDLISAKDF-HMKR------KGGNQ 499
PRK14133 PRK14133
DNA polymerase IV; Provisional
 98-448 3.54e-73

DNA polymerase IV; Provisional


Pssm-ID: 184529 [Multi-domain]  Cd Length: 347  Bit Score: 241.93  E-value: 3.54e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815  98 LNNTIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 174
Cdd:PRK14133    1 MDRVIIHVDMDAFFASVEQMDNPKLKGKPVIVGGISergVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVRHERYK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 175 AVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQErqdwPED-----KRRYFIKMGNYLKIGIAPNTMLAKVCSDKNKPN 249
Cdd:PRK14133   81 EVSKNIFKILYEVTPIVEPVSIDEAYLDITNIKEE----PIKiakyiKKKVKKETGLTLSVGISYNKFLAKLASDWNKPD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 250 GQYQIlpSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ-QRALLSLLFSETSWHYFLHIAlGLGSTDLAR 328
Cdd:PRK14133  157 GIKII--TEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKlSREFLIEYFGKFGVEIYERIR-GIDYREVEV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 329 DGERKSMSVERTFS-EISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIA 407
Cdd:PRK14133  234 SRERKSIGKETTLKkDTKDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQTHTKSKTLNDYIRDKEEIYNVA 313

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1907093815 408 KELLRtEVNVGSPhplrLRLMGVRMSTFSSEddrKHQQRSI 448
Cdd:PRK14133  314 CEILE-HINIKEP----IRLIGLSVSNLSEN---KIEQLSF 346
PRK02794 PRK02794
DNA polymerase IV; Provisional
 101-440 4.87e-70

DNA polymerase IV; Provisional


Pssm-ID: 179473 [Multi-domain]  Cd Length: 419  Bit Score: 235.98  E-value: 4.87e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVG--SMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 178
Cdd:PRK02794   37 SIAHIDCDAFYASVEKRDNPELRDKPVIIGggKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKPDMEKYVRVGR 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 179 EVKEILAEYDPNFMAMSLDEAYLNI--TQHLQERqdwPEDK------RRYFIKMGNYLKIGIAPNTMLAKVCSDKNKPNG 250
Cdd:PRK02794  117 EVRAMMQALTPLVEPLSIDEAFLDLsgTERLHGA---PPAVvlarfaRRVEREIGITVSVGLSYNKFLAKIASDLDKPRG 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 251 qYQILpSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ--QRALLSLLFSETSWHYflHIALGLGSTDLAR 328
Cdd:PRK02794  194 -FSVI-GRAEALAFLAPKPVGIIWGVGPATAARLARDGIRTIGDLQRadEADLMRRFGSMGLRLW--RLARGIDDRKVSP 269

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 329 DGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIA 407
Cdd:PRK02794  270 DREAKSVSAETTFETdLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRLRTRRRTLEDPTQLADRIFRTA 349

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1907093815 408 KELLRTEvnvgsPHPLRLRLMGVRMSTFSSEDD 440
Cdd:PRK02794  350 RELLEKE-----TDGTAFRLIGIGVSDLSPADE 377
PRK03348 PRK03348
DNA polymerase IV; Provisional
 101-437 8.23e-62

DNA polymerase IV; Provisional


Pssm-ID: 235118 [Multi-domain]  Cd Length: 454  Bit Score: 214.80  E-value: 8.23e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNYHARRFGVRAAMPGFIAKRLCPQL-IIVPPNFDKYRAV 176
Cdd:PRK03348    6 WVLHLDMDAFFASVEQLTRPTLRGRPVLVGGLGgrgVVAGASYEARVFGARSAMPMHQARRLVGNGaVVLPPRFVVYRAA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 177 SKEVKEILAEYDPNFMAMSLDEAYLNITQHL----QERQDWPED-KRRYFIKMGNYLKIGIAPNTMLAKVCSDKNKPNGQ 251
Cdd:PRK03348   86 SRRVFDTLRELSPVVEQLSFDEAFVEPAELAgasaEEVEAFAERlRARVREETGLPASVGAGSGKQIAKIASGLAKPDGI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 252 YQILPSRSavMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ--QRALLSLLfSETSWHYFLHIALGLGSTDLARD 329
Cdd:PRK03348  166 RVVPPGEE--RELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAAlsEAEVANLL-GATVGPALHRLARGIDDRPVAER 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 330 GERKSMSVERTFSEISKTEEQYSLCQELCAELAHD-LQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAK 408
Cdd:PRK03348  243 AEAKQISAESTFAVDLTTRAQLREAIERIAEHAHRrLLKDGRGARTVTVKLRKSDFSTLTRSATLPYATDDAAVLAATAR 322

                         330       340
                  ....*....|....*....|....*....
gi 1907093815 409 ELLRTEVNVGSphplrLRLMGVRMSTFSS 437
Cdd:PRK03348  323 RLLLDPDEIGP-----IRLVGVGFSGLSD 346
PolY cd00424
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 103-433 2.58e-58

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176453 [Multi-domain]  Cd Length: 343  Bit Score: 201.82  E-value: 2.58e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 103 VHVDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSK 178
Cdd:cd00424     1 LHIDFDNFFASVEQLARPELKGRPVVVvpfnSDSTCVIACSYEARKYGVKRGMPVREARKMCPNLILVPARLDLYRRLSE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 179 EVKEILAEYDPNFMAMSLDEAYLNIT---QHLQERQDWPED-KRRYFIKMGNY-LKIGIAPNTMLAKVCSDKNKPNGQYQ 253
Cdd:cd00424    81 RLLSELEEVAPLVEVASIDELFLDLTgsaRLLGLGSEVALRiKRHIAEQLGGItASIGIASNKLLAKLAAKYAKPDGLTI 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 254 ILPsrSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELY--QQRALLSLLFSETS--WHYFLHialGLGSTDLARD 329
Cdd:cd00424   161 LDP--EDLPGFLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLaaSPDALLALWGGVSGerLWYALR---GIDDEPLSPP 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 330 GERKSMSVERTFSEISKTEEQ-YSLCQELCAELAHDLQKEGLKGRTVTIKLKNVN------FEVKTRASTVPAAISTaEE 402
Cdd:cd00424   236 RPRKSFSHERVLPRDSRNAEDaRPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDgrwsghADIPSRSAPRPISTED-GE 314

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1907093815 403 IFAIAKELLRTEVNVgsPHPLRLRLMGVRMS 433
Cdd:cd00424   315 LLHALDKLWRALLDD--KGPRRLRRLGVRLS 343
PRK03858 PRK03858
DNA polymerase IV; Validated
 101-466 1.93e-56

DNA polymerase IV; Validated


Pssm-ID: 179663 [Multi-domain]  Cd Length: 396  Bit Score: 198.29  E-value: 1.93e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 101 TIVHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEV 180
Cdd:PRK03858    5 SILHADLDSFYASVEQRDDPALRGRPVIVGGGVVLAAS-YEAKAYGVRTAMGGRQARRLCPQAVVVPPRMSAYSRASKAV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 181 KEILAEYDPNFMAMSLDEAYLNIT--QHLQERqdwPED-----KRRYFIKMGNYLKIGIAPNTMLAKVCSDKNKPNGQYQ 253
Cdd:PRK03858   84 FEVFRDTTPLVEGLSIDEAFLDVGglRRISGT---PVQiaarlRRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 254 ILPSRSavMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ--QRALLSLLFSETSWHyfLHiALGlgstdLARD-- 329
Cdd:PRK03858  161 VPPDRE--LAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAElpESALVSLLGPAAGRH--LH-ALA-----HNRDpr 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 330 -----GERKSMSVERTFSEISKTEEQY--SLCQeLCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEE 402
Cdd:PRK03858  231 rvetgRRRRSVGAQRALGRGPNSPAEVdaVVVA-LVDRVARRMRAAGRTGRTVVLRLRFDDFTRATRSHTLPRPTASTAT 309

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1907093815 403 IFAIAKELLRtevNVGSPHPLR-LRLMGVRMSTFsseDDRKHQQRSIIGFLQAGNQALSSTGDSL 466
Cdd:PRK03858  310 LLAAARDLVA---AAAPLIAERgLTLVGFAVSNL---DDDGAQQLELPFGLRRPGSALDAALDAV 368
PRK01810 PRK01810
DNA polymerase IV; Validated
 102-487 2.14e-56

DNA polymerase IV; Validated


Pssm-ID: 179337 [Multi-domain]  Cd Length: 407  Bit Score: 198.72  E-value: 2.14e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 102 IVHVDMDAFYAAVEMRDNPELKDKPIAV-GSMS----MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAV 176
Cdd:PRK01810    7 IFHVDMNSFFASVEIAYDPSLQGKPLAVaGNEKerkgIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRRPNFDRYREA 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 177 SKEVKEILAEYDPNFMAMSLDEAYLNIT----------------QHLQERQDWPedkrryfikmgnyLKIGIAPNTMLAK 240
Cdd:PRK01810   87 SRQMFQILSEFTPLVQPVSIDEGYLDITdcyalgspleiakmiqQRLLTELQLP-------------CSIGIAPNKFLAK 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 241 VCSDKNKPNGqYQILPSRSaVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQ-QRALLSLLFSETSWHyfLH-IA 318
Cdd:PRK01810  154 MASDMKKPLG-ITVLRKRD-VPEMLWPLPVGEMHGIGEKTAEKLKDIGIQTIGDLAKaDEHILRAKLGINGVR--LQrRA 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 319 LGL--GSTDLARDGERKSMSVERTFSEISKTE-EQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPA 395
Cdd:PRK01810  230 NGIddRPVDPEAIYQFKSVGNSTTLSHDMDEEkELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRRTITRSKTLKN 309

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 396 AISTAEEIFAIAKELLRTEVNvGSPhplrLRLMGV-------------RMSTFSSEDDRKHQQ-RSIIGFLQA--GNQAL 459
Cdd:PRK01810  310 PIWEKRDIFQAASRLFKQHWN-GDP----VRLLGVtatdlewkteavkQLDLFSFEEDAKEEPlLAVIDQINDkyGMPLL 384

                         410       420
                  ....*....|....*....|....*...
gi 1907093815 460 SSTGDSLDKTDKTElakplEMSHKKSFF 487
Cdd:PRK01810  385 QRGSQLLRKQEKTF-----GTSFEKDFM 407
PolY_Rev1 cd01701
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ...
 98-413 1.36e-50

DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.


Pssm-ID: 176455 [Multi-domain]  Cd Length: 404  Bit Score: 182.51  E-value: 1.36e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815  98 LNNTIVHVDMDAFYAAVEMRDNPELKDKPIAV----GSMSMLATSNYHARRFGVRAAMpgFI--AKRLCPQLIIVPPNFD 171
Cdd:cd01701    45 LQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVchgkGPNSEIASCNYEARSYGIKNGM--WVgqAKKLCPQLVTLPYDFE 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 172 KYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQDWPED-----KRRYFIKMGNYLKIGIAPNTMLAKVCSDKN 246
Cdd:cd01701   123 AYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLEETYELPEElaeaiRNEIRETTGCSASVGIGPNILLARLATRKA 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 247 KPNGQYQILPsrSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ----RALLSLLFSETSWHyFLHIALGLG 322
Cdd:cd01701   203 KPDGQYHLSA--EKVEEFLSQLKVGDLPGVGSSLAEKLVKLFGDTCGGLELRsktkEKLQKVLGPKTGEK-LYDYCRGID 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 323 STDLARDGERKSMSVERTFSEISKTEEQ-YSLCQELCAELAHDLQKEGLKGRTVTIKLKN------------------VN 383
Cdd:cd01701   280 DRPVTGEKERKSVSAEINYGIRFTNVDDvEQFLQRLSEELSKRLEESNVTGRQITLKLMKrapgapieppkymghgicDS 359

                         330       340       350
                  ....*....|....*....|....*....|
gi 1907093815 384 FevkTRASTVPAAISTAEEIFAIAKELLRT 413
Cdd:cd01701   360 F---SKSSTLGVATDDSGVIGTEAKKLFRD 386
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 105-244 4.61e-48

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 166.60  E-value: 4.61e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 105 VDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVK 181
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGgngRGIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVVPPDLELYRRASRKIF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1907093815 182 EILAEY-DPNFMAMSLDEAYLNITqHLQERQDWPED-----KRRYFIKMGNYLKIGIAPNTMLAKVCSD 244
Cdd:pfam00817  81 EILRRFsTPKVEQASIDEAFLDLT-GLEKLFGAEEAlakrlRREIAEETGLTCSIGIAPNKLLAKLASD 148
PRK03103 PRK03103
DNA polymerase IV; Reviewed
 102-448 1.92e-41

DNA polymerase IV; Reviewed


Pssm-ID: 235104 [Multi-domain]  Cd Length: 409  Bit Score: 156.70  E-value: 1.92e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 102 IVHVDMDAFYAAVEMRDNPELKDKPIAVG------SMSMLATSnYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRA 175
Cdd:PRK03103    5 ILLVDMQSFYASVEKAANPELKGRPVIVSgdperrSGVVLAAC-PLAKAYGVKTAERLWEAQQKCPDLVVVKPRMQRYID 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 176 VSKEVKEILAEYDPNFMAMSLDEAYLNIT-------------QHLQERqdwpedKRRYFikmGNYLKIGIAPNTMLAKVC 242
Cdd:PRK03103   84 VSLQITRILEDFTDLVEPFSIDEQFLDVTgsqklfgspleiaQKIQQR------IMRET---GVYARVGIGPNKLLAKMA 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 243 SD---KNKPNGQYQIlpSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELyqqrALLSLLFSETSW----HYFL 315
Cdd:PRK03103  155 CDnfaKKNPDGLFTL--DKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQL----ANTPLERLKKRWgingEVLW 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 316 HIALGLGSTDLARDG--ERKSMSVERTF-SEISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKT---R 389
Cdd:PRK03103  229 RTANGIDYSPVTPHSldRQKAIGHQMTLpRDYRGFEEIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADFDWPTgfsR 308

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1907093815 390 ASTVPAAISTAEEIFAIAKELLRTEVNvGSPhplrLRLMGVRMSTFSSED-------DRKHQQRSI 448
Cdd:PRK03103  309 QMTLPEPTNLAMEVYEAACKLFHRHWD-GKP----VRRVGVTLSNLVSDDvwqlslfGDRERKRSL 369
PRK03352 PRK03352
DNA polymerase IV; Validated
 102-431 3.00e-39

DNA polymerase IV; Validated


Pssm-ID: 179564 [Multi-domain]  Cd Length: 346  Bit Score: 148.63  E-value: 3.00e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 102 IVHVDMDAFYAAVEMRDNPELKDKPIAVG-------SMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 174
Cdd:PRK03352    7 VLHVDLDQFIAAVELLRRPELAGLPVIVGgngdptePRKVVTCASYEARAFGVRAGMPLRTAARRCPDAVFLPSDPAAYD 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 175 AVSKEVKEILAEYDPNFMAMSLDEAYLNItqhlqeRQDWPED-----KRRYFIKMGNYLKIGIAPNTMLAKVCSDKNKPN 249
Cdd:PRK03352   87 AASEEVMATLRDLGVPVEVWGWDEAFLGV------DTDDPEAlaeeiRAAVLERTGLSCSVGIGDNKLRAKIATGFAKPA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 250 GQYQIlpSRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTEL-YQQRALLSLLFSETSWHYFLHIALGLGSTDL-A 327
Cdd:PRK03352  161 GVFRL--TDANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLaAADPAELAATFGPTTGPWLLLLARGGGDTEVsA 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 328 RDGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAI 406
Cdd:PRK03352  239 EPWVPRSRSREVTFPQdLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATFYTRTKIRKLPEPTTDPDVIEAA 318

                         330       340
                  ....*....|....*....|....*
gi 1907093815 407 AKELLrTEVNVGSPhplrLRLMGVR 431
Cdd:PRK03352  319 ALDVL-DRFELDRP----VRLLGVR 338
PRK01216 PRK01216
DNA polymerase IV; Validated
 102-289 1.88e-36

DNA polymerase IV; Validated


Pssm-ID: 179251 [Multi-domain]  Cd Length: 351  Bit Score: 140.70  E-value: 1.88e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 102 IVHVDMDAFYAAVEMRDNPELKDKPIAVGSMS-------MLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYR 174
Cdd:PRK01216    3 ILFVDFDYFFAQVEEVLNPSLKGKPVVVCVYSgrfedsgAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEVYQ 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 175 AVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQERQD----WPEDKRRYFIKMGNYLKIGIAPNTMLAKVCSDKNKPNG 250
Cdd:PRK01216   83 QVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKNYQDaynlGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNG 162

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1907093815 251 QYQILPSRsaVMDFIKDLPIRKVSGIGKVTEKMLMALGI 289
Cdd:PRK01216  163 IKVIDDEE--VKRFINELDIADIPGIGDITAEKLKKLGV 199
PolY_Pol_eta cd01702
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ...
 103-412 6.35e-36

DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.


Pssm-ID: 176456 [Multi-domain]  Cd Length: 359  Bit Score: 139.37  E-value: 6.35e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLII--VPP------------ 168
Cdd:cd01702     1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILahVATykkgedeadyhe 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 169 ---------NFDKYRAVSKEVKEILAEYDPNFMAMSLDEAYLNITQHLQER-QDWPEDKRRYfikmgnYLKIGIAPNTML 238
Cdd:cd01702    81 npsparhkvSLDPYRRASRKILNILKRFGDVVEKASIDEAYLDLGSRIVEEiRQQVYDELGY------TCSAGIAHNKML 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 239 AKVCSDKNKPNGQyQILPSrSAVMDFIKDLPIRKVSGI-GKVTEKMLMALGIVTCTELYQQRALLSLL---FSET--SWH 312
Cdd:cd01702   155 AKLASGMNKPNAQ-TILRN-DAVASFLSSLPITSIRGLgGKLGEEIIDLLGLPTEGDVAGFRSSESDLqehFGEKlgEWL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 313 YflHIALGLGSTDLARDGERKSMSVERTFS--EISKTEEQYSLCQELCAELAHDLQKE----GLKGRTVTIKLKNVNFEV 386
Cdd:cd01702   233 Y--NLLRGIDHEPVKPRPLPKSMGSSKNFPgkTALSTEDVQHWLLVLASELNSRLEDDryenNRRPKTLVLSLRQRGDGV 310

                         330       340
                  ....*....|....*....|....*.
gi 1907093815 387 KTRASTvPAAISTAEEIFAIAKELLR 412
Cdd:cd01702   311 RRSRSC-ALPRYDAQKIVKDAFKLIK 335
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 103-298 2.05e-35

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 138.37  E-value: 2.05e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 103 VHVDMDAFYAAVEMRDNPELKDKPIAVGSMSMLATSNYHARRFGVRAAMPGFIAKRLCPQLIIVP-PNFDKYRAVSKEVK 181
Cdd:cd01703     1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNgEDLTPFRDMSKKVY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 182 EILAEYDPNFMA--MSLDEAYLNITQ-------HLQErqdwpEDKRRYFIKMGNYLKIGIAPNTMLAKVCSDKNKPNGQY 252
Cdd:cd01703    81 RLLRSYSWNDRVerLGFDENFMDVTEmrllvasHIAY-----EMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQT 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1907093815 253 QILP-SRSAVMDFIKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ 298
Cdd:cd01703   156 TLLPpSCADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEF 202
PolY_Pol_V_umuC cd01700
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ...
 105-412 2.50e-29

umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.


Pssm-ID: 176454 [Multi-domain]  Cd Length: 344  Bit Score: 119.96  E-value: 2.50e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 105 VDMDAFYAAVEMRDNPELKDKPIAVGS---MSMLATSNyHARRFGVRAAMPGFIAKRLCPQL--IIVPPNFDKYRAVSKE 179
Cdd:cd01700     3 VDCNSFYASCERVFRPLLLGRPLVVLSnndGCVIARSP-EAKALGIKMGSPYFKVPDLLERHgvAVFSSNYALYGDMSRR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 180 VKEILAEYDPNFMAMSLDEAYLNIT--QHLQERQDWPED-KRRYFIKMGNYLKIGIAPNTMLAKVCSD----KNKPNGQY 252
Cdd:cd01700    82 IMSILERFSPDVEVYSIDESFLDLTgsLRFGDLEELARKiRRRILQETGIPVTVGIGPTKTLAKLANDlakkKNPYGGVV 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 253 QIL--PSRSAVMdfiKDLPIRKVSGIGKVTEKMLMALGIVT-----CTELYQQRALLSLLFSETSWHyfLHialGLGSTD 325
Cdd:cd01700   162 DLTdeEVRDKLL---KILPVGDVWGIGRRTAKKLNAMGIHTagdlaQADPDLLRKKFGVVGERLVRE--LN---GIDCLP 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 326 LAR-DGERKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNF--EVKTRASTVPAAISTAE 401
Cdd:cd01700   234 LEEyPPPKKSIGSSRSFGRdVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFsrQPKYYSATNTLPYPTND 313

                         330
                  ....*....|...
gi 1907093815 402 --EIFAIAKELLR 412
Cdd:cd01700   314 trEIVKAALRLLY 326
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 332-439 2.78e-23

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 94.93  E-value: 2.78e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 332 RKSMSVERTFSE-ISKTEEQYSLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKEL 410
Cdd:pfam11799   1 RKSIGAERTFGRdLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFRTITRSVTLPSPTDDTDEIYRAALRL 80

                          90       100
                  ....*....|....*....|....*....
gi 1907093815 411 LRTEVnvgspHPLRLRLMGVRMSTFSSED 439
Cdd:pfam11799  81 LRRLY-----RGRPVRLLGVSLSNLVPEG 104
umuC PRK03609
translesion error-prone DNA polymerase V subunit UmuC;
104-298 1.34e-09

translesion error-prone DNA polymerase V subunit UmuC;


Pssm-ID: 179607 [Multi-domain]  Cd Length: 422  Bit Score: 60.93  E-value: 1.34e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 104 HVDMDAFYAAVEMRDNPELKDKPIAVGSMS---MLATSNyHARRFGVRAAMPGFIAK--RLCPQLIIVPPNFDKYRAVSK 178
Cdd:PRK03609    4 LCDVNSFYASCETVFRPDLRGKPVVVLSNNdgcVIARSA-EAKALGIKMGDPWFKQKdlFRRCGVVCFSSNYELYADMSN 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 179 EVKEILAEYDPNFMAMSLDEAYLNIT--QHLQERQDWPEDKRRYfIKMGNYLKIG--IAPNTMLAKVCSDKNKpngQYQi 254
Cdd:PRK03609   83 RVMSTLEELSPRVEIYSIDEAFCDLTgvRNCRDLTDFGREIRAT-VLQRTHLTVGvgIAQTKTLAKLANHAAK---KWQ- 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1907093815 255 lPSRSAVMDF---------IKDLPIRKVSGIGKVTEKMLMALGIVTCTELYQQ 298
Cdd:PRK03609  158 -RQTGGVVDLsnlerqrklLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADT 209
PolY_like cd03468
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ...
 117-412 1.24e-08

DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176458 [Multi-domain]  Cd Length: 335  Bit Score: 57.39  E-value: 1.24e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 117 RDNPELKDKPIAV----GSMSMLATsNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKEVKEILAEYDPNFM 192
Cdd:cd03468    15 RNRPADDEAPLAVverkKAGRILAC-NAAARAAGVRPGMPLAEALALCPNLQVVEYDPEADARALQELALWLLRFTPLVA 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 193 AMSLDEAYLNITQHLQERQDWP---EDKRRYFIKMGNYLKIGIAPNTMLAKVCSDKNKPNGQYQIlPSRSAVMDFIKDLP 269
Cdd:cd03468    94 LDGPDGLLLDVTGCLHLFGGEDalaASLRAALATLGLSARAGIADTPGAAWLLARAGGGRGVLRR-EALAAALVLLAPLP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907093815 270 IRkVSGIGKVTEKMLMALGIVT---CTELYqqRALLSLLFSE--TSWHYFLhialgLGSTDLARDG----ERKSMSVERT 340
Cdd:cd03468   173 VA-ALRLPPETVELLARLGLRTlgdLAALP--RAELARRFGLalLLRLDQA-----YGRDPEPLLFspppPAFDFRLELQ 244

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1907093815 341 F-SEISKTEEQysLCQELCAELAHDLQKEGLKGRTVTIKLKNVNFEVKTRASTVPAAISTAEEIFAIAKELLR 412
Cdd:cd03468   245 LeEPIARGLLF--PLRRLLEQLCAFLALRGLGARRLSLTLFREDGRVTRVLVGLARPSRDDLPLLRLLRERLE 315
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 540-565 2.04e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 41.82  E-value: 2.04e-05
                           10        20
                   ....*....|....*....|....*.
gi 1907093815  540 FICPVCFREqegVSLEAFNEHVDECL 565
Cdd:smart00734   2 VQCPVCFRE---VPENLINSHLDSCL 24
IMS_HHH pfam11798
IMS family HHH motif; These proteins are involved in UV protection, eg.
 258-289 4.16e-05

IMS family HHH motif; These proteins are involved in UV protection, eg.


Pssm-ID: 432081 [Multi-domain]  Cd Length: 32  Bit Score: 40.84  E-value: 4.16e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1907093815 258 RSAVMDFIKDLPIRKVSGIGKVTEKMLMALGI 289
Cdd:pfam11798   1 PDDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
ZnF_Rad18 smart00734
Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative ...
 681-707 6.31e-05

Rad18-like CCHC zinc finger; Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.


Pssm-ID: 128973 [Multi-domain]  Cd Length: 24  Bit Score: 40.28  E-value: 6.31e-05
                           10        20
                   ....*....|....*....|....*..
gi 1907093815  681 ALVCPVCNLEQetsDLTLFNIHVDICL 707
Cdd:smart00734   1 LVQCPVCFREV---PENLINSHLDSCL 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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