NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1907109872|ref|XP_036015002|]
View 

cadherin EGF LAG seven-pass G-type receptor 1 isoform X6 [Mus musculus]

Protein Classification

cadherin repeat domain-containing protein; laminin G domain-containing protein( domain architecture ID 10182040)

cadherin repeat domain-containing protein similar to Homo sapiens desmoglein-2, which is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion; cadherins are are calcium-dependent cell adhesion proteins that preferentially interact with themselves in connecting cells| laminin G (lLamG) domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 808-903 4.39e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 132.44  E-value: 4.39e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  808 HYTVSVSEDRPVGTSIATISATDEDTGENARITYVLEDPVPQ--FRIDPDTGTIYTMTELDYEDQAAYTLAITAQDNGIP 885
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1907109872  886 QKSDTTSLEILILDANDN 903
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 479-576 1.37e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.20  E-value: 1.37e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  479 YVVQVPEDVAVNTAVLRVQATDRDQGQNAAIHYSIVSGNLKGQFYLHSLSGSLDVINPLDFEAIREYTLRIKAQDGGRPP 558
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*...
gi 1907109872  559 LiNSSGLVSVQVLDVNDN 576
Cdd:cd11304     82 L-SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 264-364 1.46e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.42  E-value: 1.46e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  264 SYQVSVPENEPAGTAVIELRAHDPDEGDAGRLSYQmeaLFDERSNGYFLIDAATGAVTTARSLDRETKDTHVLKVSAVDH 343
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1907109872  344 GSPRRSAATYLTVTVSDTNDH 364
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 372-470 4.33e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 4.33e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  372 EYRERIRENLEVGYEVLTIRATDGDAPSNANMRYRLLEG-AGGVFEIDARSGVVRTRAVVDREEAAEYQLLVEANDQGRN 450
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90       100
                   ....*....|....*....|
gi 1907109872  451 pgPLSASATVHIVVEDENDN 470
Cdd:cd11304     81 --PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 912-1010 1.08e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 1.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  912 YQGSVFEDAPPSTSVLQVSATDRDSGPNGRLLYTFQgGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSP 991
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1907109872  992 nPLSASVGIQVSVLDINDN 1010
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 584-698 7.82e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 7.82e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  584 PFQAAVLENVPLGHSVLHIQAVDADAGENARLQYRLVDtastivggssvdsenpaSAPDFPFQIHNSSGWITVCAELDRE 663
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS-----------------GNEDGLFSIDPSTGEITTAKPLDRE 63

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1907109872  664 EVEHYSFGVEAVDHGSPAMSSSASVSITVLDVNDN 698
Cdd:cd11304     64 EQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1018-1112 9.04e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 9.04e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1018 ELELFVEENSPVGSVVARIRANDPDEGPNAQIMYQIVEGNVPEVFQLDLLSGDLRALVELDFEVRRDYMLVVQAT---SA 1094
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdggGP 80

                           90
                   ....*....|....*...
gi 1907109872 1095 PLVSRATVHIRLLDQNDN 1112
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1459-1642 1.86e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 106.73  E-value: 1.86e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1459 TRSFPPQSFVTFRGLR-QRFHFTVSLAFATQDRNALLLYNGRFNeKHDFIALEIVEEQLQLTFSAGETTTTVTPQVPggV 1537
Cdd:cd00110      1 GVSFSGSSYVRLPTLPaPRTRLSISFSFRTTSPNGLLLYAGSQN-GGDFLALELEDGRLVLRYDLGSGSLVLSSKTP--L 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1538 SDGRWHSVLVQYYNkpnighlglphgpsgeKVAVVTVDDCDaavavhfgsyvgnyscAAQGTQSGSKKSLDLTGPLLLGG 1617
Cdd:cd00110     78 NDGQWHSVSVERNG----------------RSVTLSVDGER----------------VVESGSPGGSALLNLDGPLYLGG 125

                          170       180
                   ....*....|....*....|....*.
gi 1907109872 1618 VPNLPEDFPVHSRQ-FVGCMRNLSID 1642
Cdd:cd00110    126 LPEDLKSPGLPVSPgFVGCIRDLKVN 151
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 706-800 3.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 3.30e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  706 VYELRLNEDAAVGSSVLTLRARDRD--ANSVITYQLTGGNTRNRFALSSQSggGLITLALPLDYKQERQYVLAVTASDG- 782
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPST--GEITTAKPLDREEQSSYTLTVTATDGg 78

                           90       100
                   ....*....|....*....|
gi 1907109872  783 --TRSHTAQVFINVTDANTH 800
Cdd:cd11304     79 gpPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1132-1213 2.84e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 2.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1132 NSFPSGVIGRIPAHDPDLSD--SLNYTFLQGNELSLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTALCTL 1208
Cdd:cd11304      9 NAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPPLSSTATV 88


                   ....*
gi 1907109872 1209 RVTII 1213
Cdd:cd11304     89 TITVL 93
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1379-1414 6.08e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.02  E-value: 6.08e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907109872 1379 IDLCYS-NPCGANGRCRSREGGYTCECFEDFTGEHCQ 1414
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1666-1700 7.69e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 7.69e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907109872 1666 NFCD-GTSCQNGGTCVNRWNTYLCECPLRFGGKNCE 1700
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1422-1456 9.08e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 9.08e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907109872 1422 CASG-VCKNGGTCVNLlIGGFHCVCPPGeYEHPYCE 1456
Cdd:cd00054      5 CASGnPCQNGGTCVNT-VGSYRCSCPPG-YTGRNCE 38
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 808-903 4.39e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 132.44  E-value: 4.39e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  808 HYTVSVSEDRPVGTSIATISATDEDTGENARITYVLEDPVPQ--FRIDPDTGTIYTMTELDYEDQAAYTLAITAQDNGIP 885
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1907109872  886 QKSDTTSLEILILDANDN 903
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 479-576 1.37e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.20  E-value: 1.37e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  479 YVVQVPEDVAVNTAVLRVQATDRDQGQNAAIHYSIVSGNLKGQFYLHSLSGSLDVINPLDFEAIREYTLRIKAQDGGRPP 558
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*...
gi 1907109872  559 LiNSSGLVSVQVLDVNDN 576
Cdd:cd11304     82 L-SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 264-364 1.46e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.42  E-value: 1.46e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  264 SYQVSVPENEPAGTAVIELRAHDPDEGDAGRLSYQmeaLFDERSNGYFLIDAATGAVTTARSLDRETKDTHVLKVSAVDH 343
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1907109872  344 GSPRRSAATYLTVTVSDTNDH 364
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 372-470 4.33e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 4.33e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  372 EYRERIRENLEVGYEVLTIRATDGDAPSNANMRYRLLEG-AGGVFEIDARSGVVRTRAVVDREEAAEYQLLVEANDQGRN 450
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90       100
                   ....*....|....*....|
gi 1907109872  451 pgPLSASATVHIVVEDENDN 470
Cdd:cd11304     81 --PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 912-1010 1.08e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 1.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  912 YQGSVFEDAPPSTSVLQVSATDRDSGPNGRLLYTFQgGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSP 991
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1907109872  992 nPLSASVGIQVSVLDINDN 1010
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 584-698 7.82e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 7.82e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  584 PFQAAVLENVPLGHSVLHIQAVDADAGENARLQYRLVDtastivggssvdsenpaSAPDFPFQIHNSSGWITVCAELDRE 663
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS-----------------GNEDGLFSIDPSTGEITTAKPLDRE 63

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1907109872  664 EVEHYSFGVEAVDHGSPAMSSSASVSITVLDVNDN 698
Cdd:cd11304     64 EQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1018-1112 9.04e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 9.04e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1018 ELELFVEENSPVGSVVARIRANDPDEGPNAQIMYQIVEGNVPEVFQLDLLSGDLRALVELDFEVRRDYMLVVQAT---SA 1094
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdggGP 80

                           90
                   ....*....|....*...
gi 1907109872 1095 PLVSRATVHIRLLDQNDN 1112
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1459-1642 1.86e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 106.73  E-value: 1.86e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1459 TRSFPPQSFVTFRGLR-QRFHFTVSLAFATQDRNALLLYNGRFNeKHDFIALEIVEEQLQLTFSAGETTTTVTPQVPggV 1537
Cdd:cd00110      1 GVSFSGSSYVRLPTLPaPRTRLSISFSFRTTSPNGLLLYAGSQN-GGDFLALELEDGRLVLRYDLGSGSLVLSSKTP--L 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1538 SDGRWHSVLVQYYNkpnighlglphgpsgeKVAVVTVDDCDaavavhfgsyvgnyscAAQGTQSGSKKSLDLTGPLLLGG 1617
Cdd:cd00110     78 NDGQWHSVSVERNG----------------RSVTLSVDGER----------------VVESGSPGGSALLNLDGPLYLGG 125

                          170       180
                   ....*....|....*....|....*.
gi 1907109872 1618 VPNLPEDFPVHSRQ-FVGCMRNLSID 1642
Cdd:cd00110    126 LPEDLKSPGLPVSPgFVGCIRDLKVN 151
Cadherin pfam00028
Cadherin domain;
809-898 5.31e-26

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 103.53  E-value: 5.31e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  809 YTVSVSEDRPVGTSIATISATDEDTGENARITY-VLEDPVPQ-FRIDPDTGTIYTMTELDYEDQAAYTLAITAQDNGIPQ 886
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1907109872  887 KSDTTSLEILIL 898
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 827-905 5.96e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.81  E-value: 5.96e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   827 SATDEDTGENARITYVL--EDPVPQFRIDPDTGTIYTMTELDYEDQAAYTLAITAQDNGIPQKSDTTSLEILILDANDNA 904
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1907109872   905 P 905
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
479-571 5.81e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.45  E-value: 5.81e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  479 YVVQVPEDVAVNTAVLRVQATDRDQGQNAAIHYSIVSGNLKGQFYLHSLSGSLDVINPLDFEAIREYTLRIKAQDGGRPP 558
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|...
gi 1907109872  559 LiNSSGLVSVQVL 571
Cdd:pfam00028   81 L-SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 497-578 2.52e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.19  E-value: 2.52e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   497 QATDRDQGQNAAIHYSIVSGNLKGQFYLHSLSGSLDVINPLDFEAIREYTLRIKAQDGGRPPLiNSSGLVSVQVLDVNDN 576
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTITVLDVNDN 79


                    ..
gi 1907109872   577 AP 578
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 391-472 1.71e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 1.71e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   391 RATDGDAPSNANMRYRLLEG-AGGVFEIDARSGVVRTRAVVDREEAAEYQLLVEANDQGrnPGPLSASATVHIVVEDEND 469
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVND 78


                    ...
gi 1907109872   470 NYP 472
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 706-800 3.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 3.30e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  706 VYELRLNEDAAVGSSVLTLRARDRD--ANSVITYQLTGGNTRNRFALSSQSggGLITLALPLDYKQERQYVLAVTASDG- 782
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPST--GEITTAKPLDREEQSSYTLTVTATDGg 78

                           90       100
                   ....*....|....*....|
gi 1907109872  783 --TRSHTAQVFINVTDANTH 800
Cdd:cd11304     79 gpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-366 3.99e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 3.99e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   283 RAHDPDEGDAGRLSYQmeaLFDERSNGYFLIDAATGAVTTARSLDRETKDTHVLKVSAVDHGSPRRSAATYLTVTVSDTN 362
Cdd:smart00112    1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1907109872   363 DHSP 366
Cdd:smart00112   78 DNAP 81
LamG smart00282
Laminin G domain;
1480-1644 5.51e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 96.25  E-value: 5.51e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  1480 TVSLAFATQDRNALLLYNGrFNEKHDFIALEIVEEQLQLTFSAGETTTTVTPQvPGGVSDGRWHSVLVQYYNkpnighlg 1559
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAG-SKGGGDYLALELRDGRLVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNG-------- 70

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  1560 lphgpsgeKVAVVTVDDCDAAVAVHFgsyvgnyscaaqgtqsGSKKSLDLTGPLLLGGVPNLPEDFPVHSRQ-FVGCMRN 1638
Cdd:smart00282   71 --------RSVTLSVDGGNRVSGESP----------------GGLTILNLDGPLYLGGLPEDLKLPPLPVTPgFRGCIRN 126


                    ....*.
gi 1907109872  1639 LSIDGR 1644
Cdd:smart00282  127 LKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 603-700 6.01e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.34  E-value: 6.01e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   603 QAVDADAGENARLQYRLVDtastivggssvdsenpaSAPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPAM 682
Cdd:smart00112    1 SATDADSGENGKVTYSILS-----------------GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL 63

                            90
                    ....*....|....*...
gi 1907109872   683 SSSASVSITVLDVNDNDP 700
Cdd:smart00112   64 SSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 930-1012 2.99e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 2.99e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   930 SATDRDSGPNGRLLYTFqGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPnPLSASVGIQVSVLDIND 1009
Cdd:smart00112    1 SATDADSGENGKVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1907109872  1010 NPP 1012
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
265-358 3.39e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.36  E-value: 3.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  265 YQVSVPENEPAGTAVIELRAHDPDEGDAGRLSYQMeaLFDErSNGYFLIDAATGAVTTARSLDRETKDTHVLKVSAVDHG 344
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGG-PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....
gi 1907109872  345 SPRRSAATYLTVTV 358
Cdd:pfam00028   78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1037-1114 5.97e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 5.97e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  1037 RANDPDEGPNAQIMYQIVEGNVPEVFQLDLLSGDLRALVELDFEVRRDYMLVVQAT---SAPLVSRATVHIRLLDQNDNP 1113
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdggGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1907109872  1114 P 1114
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
373-465 3.74e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 3.74e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  373 YRERIRENLEVGYEVLTIRATDGDAPSNANMRYRLLEG-AGGVFEIDARSGVVRTRAVVDREEAAEYQLLVEANDQGrnP 451
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG--G 78

                           90
                   ....*....|....
gi 1907109872  452 GPLSASATVHIVVE 465
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1023-1107 1.26e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 1.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1023 VEENSPVGSVVARIRANDPDEGPNAQIMYQIVEGNVPEVFQLDLLSGDLRALVELDFEVRRDYMLVVQATSA---PLVSR 1099
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSggpPLSST 84


                   ....*...
gi 1907109872 1100 ATVHIRLL 1107
Cdd:pfam00028   85 ATVTITVL 92
Cadherin pfam00028
Cadherin domain;
912-1005 1.99e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 1.99e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  912 YQGSVFEDAPPSTSVLQVSATDRDSGPNGRLLYTFQGGDDGDGdFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSP 991
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|....
gi 1907109872  992 nPLSASVGIQVSVL 1005
Cdd:pfam00028   80 -PLSSTATVTITVL 92
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1485-1644 2.64e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 88.25  E-value: 2.64e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1485 FATQDRNALLLYNGrfNEKHDFIALEIVEEQLQLTFSAGETTTTVTPQvPGGVSDGRWHSVLVQYYNkpnighlglphgp 1564
Cdd:pfam02210    1 FRTRQPNGLLLYAG--GGGSDFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNG------------- 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1565 sgeKVAVVTVDDCDaavavhfgsyvgnyscAAQGTQSGSKKSLDLTGPLLLGGVPN-LPEDFPVHSRQFVGCMRNLSIDG 1643
Cdd:pfam02210   65 ---NTLTLSVDGQT----------------VVSSLPPGESLLLNLNGPLYLGGLPPlLLLPALPVRAGFVGCIRDVRVNG 125


                   .
gi 1907109872 1644 R 1644
Cdd:pfam02210  126 E 126
Cadherin pfam00028
Cadherin domain;
585-693 6.47e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 6.47e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  585 FQAAVLENVPLGHSVLHIQAVDADAGENARLQYRlvdtastIVGGSSVDSenpasapdfpFQIHNSSGWITVCAELDREE 664
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS-------ILGGGPGGN----------FRIDPDTGDISTTKPLDRES 63

                           90       100
                   ....*....|....*....|....*....
gi 1907109872  665 VEHYSFGVEAVDHGSPAMSSSASVSITVL 693
Cdd:pfam00028   64 IGEYELTVEATDSGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
707-795 1.06e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 1.06e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  707 YELRLNEDAAVGSSVLTLRARDRD--ANSVITYQLTGGNTRNRFALSSQSGggLITLALPLDYKQERQYVLAVTASDG-- 782
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlgPNGRIFYSILGGGPGGNFRIDPDTG--DISTTKPLDRESIGEYELTVEATDSgg 78

                           90
                   ....*....|....
gi 1907109872  783 -TRSHTAQVFINVT 795
Cdd:pfam00028   79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 725-802 5.24e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 5.24e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   725 RARDRD--ANSVITYQLTGGNTRNRFALSSQSGggLITLALPLDYKQERQYVLAVTASDG---TRSHTAQVFINVTDANT 799
Cdd:smart00112    1 SATDADsgENGKVTYSILSGNDDGLFSIDPETG--EITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVND 78


                    ...
gi 1907109872   800 HRP 802
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1132-1213 2.84e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 2.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1132 NSFPSGVIGRIPAHDPDLSD--SLNYTFLQGNELSLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTALCTL 1208
Cdd:cd11304      9 NAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPPLSSTATV 88


                   ....*
gi 1907109872 1209 RVTII 1213
Cdd:cd11304     89 TITVL 93
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1379-1414 6.08e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.02  E-value: 6.08e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907109872 1379 IDLCYS-NPCGANGRCRSREGGYTCECFEDFTGEHCQ 1414
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1666-1700 7.69e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 7.69e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907109872 1666 NFCD-GTSCQNGGTCVNRWNTYLCECPLRFGGKNCE 1700
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1422-1456 9.08e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 9.08e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907109872 1422 CASG-VCKNGGTCVNLlIGGFHCVCPPGeYEHPYCE 1456
Cdd:cd00054      5 CASGnPCQNGGTCVNT-VGSYRCSCPPG-YTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1422-1456 1.30e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 1.30e-08
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907109872  1422 CASG-VCKNGGTCVNLlIGGFHCVCPPGEYEHPYCE 1456
Cdd:smart00179    5 CASGnPCQNGGTCVNT-VGSYRCECPPGYTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1382-1412 6.68e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.99  E-value: 6.68e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907109872 1382 CYSNPCGANGRCRSREGGYTCECFEDFTGEH 1412
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1668-1698 7.59e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.99  E-value: 7.59e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907109872 1668 CDGTSCQNGGTCVNRWNTYLCECPLRFGGKN 1698
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1673-1700 1.02e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.02e-06
                            10        20
                    ....*....|....*....|....*....
gi 1907109872  1673 CQNGGTCVNRWNTYLCECPLRF-GGKNCE 1700
Cdd:smart00179   11 CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1378-1414 1.49e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.49e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907109872  1378 EIDLCYS-NPCGANGRCRSREGGYTCECFEDFT-GEHCQ 1414
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1427-1448 2.32e-05

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 42.71  E-value: 2.32e-05
                           10        20
                   ....*....|....*....|..
gi 1907109872 1427 CKNGGTCVNLlIGGFHCVCPPG 1448
Cdd:pfam12661    1 CQNGGTCVDG-VNGYKCQCPPG 21
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 808-903 4.39e-36

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 132.44  E-value: 4.39e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  808 HYTVSVSEDRPVGTSIATISATDEDTGENARITYVLEDPVPQ--FRIDPDTGTIYTMTELDYEDQAAYTLAITAQDNGIP 885
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDglFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*...
gi 1907109872  886 QKSDTTSLEILILDANDN 903
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 479-576 1.37e-34

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 128.20  E-value: 1.37e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  479 YVVQVPEDVAVNTAVLRVQATDRDQGQNAAIHYSIVSGNLKGQFYLHSLSGSLDVINPLDFEAIREYTLRIKAQDGGRPP 558
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPP 81

                           90
                   ....*....|....*...
gi 1907109872  559 LiNSSGLVSVQVLDVNDN 576
Cdd:cd11304     82 L-SSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 264-364 1.46e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 122.42  E-value: 1.46e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  264 SYQVSVPENEPAGTAVIELRAHDPDEGDAGRLSYQmeaLFDERSNGYFLIDAATGAVTTARSLDRETKDTHVLKVSAVDH 343
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYS---IVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDG 77

                           90       100
                   ....*....|....*....|.
gi 1907109872  344 GSPRRSAATYLTVTVSDTNDH 364
Cdd:cd11304     78 GGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 372-470 4.33e-32

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 120.88  E-value: 4.33e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  372 EYRERIRENLEVGYEVLTIRATDGDAPSNANMRYRLLEG-AGGVFEIDARSGVVRTRAVVDREEAAEYQLLVEANDQGRN 450
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGnEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90       100
                   ....*....|....*....|
gi 1907109872  451 pgPLSASATVHIVVEDENDN 470
Cdd:cd11304     81 --PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 912-1010 1.08e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 119.73  E-value: 1.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  912 YQGSVFEDAPPSTSVLQVSATDRDSGPNGRLLYTFQgGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSP 991
Cdd:cd11304      2 YEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                           90
                   ....*....|....*....
gi 1907109872  992 nPLSASVGIQVSVLDINDN 1010
Cdd:cd11304     81 -PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 584-698 7.82e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 7.82e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  584 PFQAAVLENVPLGHSVLHIQAVDADAGENARLQYRLVDtastivggssvdsenpaSAPDFPFQIHNSSGWITVCAELDRE 663
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVS-----------------GNEDGLFSIDPSTGEITTAKPLDRE 63

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1907109872  664 EVEHYSFGVEAVDHGSPAMSSSASVSITVLDVNDN 698
Cdd:cd11304     64 EQSSYTLTVTATDGGGPPLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1018-1112 9.04e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 114.33  E-value: 9.04e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1018 ELELFVEENSPVGSVVARIRANDPDEGPNAQIMYQIVEGNVPEVFQLDLLSGDLRALVELDFEVRRDYMLVVQAT---SA 1094
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATdggGP 80

                           90
                   ....*....|....*...
gi 1907109872 1095 PLVSRATVHIRLLDQNDN 1112
Cdd:cd11304     81 PLSSTATVTITVLDVNDN 98
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1459-1642 1.86e-26

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 106.73  E-value: 1.86e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1459 TRSFPPQSFVTFRGLR-QRFHFTVSLAFATQDRNALLLYNGRFNeKHDFIALEIVEEQLQLTFSAGETTTTVTPQVPggV 1537
Cdd:cd00110      1 GVSFSGSSYVRLPTLPaPRTRLSISFSFRTTSPNGLLLYAGSQN-GGDFLALELEDGRLVLRYDLGSGSLVLSSKTP--L 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1538 SDGRWHSVLVQYYNkpnighlglphgpsgeKVAVVTVDDCDaavavhfgsyvgnyscAAQGTQSGSKKSLDLTGPLLLGG 1617
Cdd:cd00110     78 NDGQWHSVSVERNG----------------RSVTLSVDGER----------------VVESGSPGGSALLNLDGPLYLGG 125

                          170       180
                   ....*....|....*....|....*.
gi 1907109872 1618 VPNLPEDFPVHSRQ-FVGCMRNLSID 1642
Cdd:cd00110    126 LPEDLKSPGLPVSPgFVGCIRDLKVN 151
Cadherin pfam00028
Cadherin domain;
809-898 5.31e-26

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 103.53  E-value: 5.31e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  809 YTVSVSEDRPVGTSIATISATDEDTGENARITY-VLEDPVPQ-FRIDPDTGTIYTMTELDYEDQAAYTLAITAQDNGIPQ 886
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYsILGGGPGGnFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|..
gi 1907109872  887 KSDTTSLEILIL 898
Cdd:pfam00028   81 LSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 827-905 5.96e-26

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 102.81  E-value: 5.96e-26
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   827 SATDEDTGENARITYVL--EDPVPQFRIDPDTGTIYTMTELDYEDQAAYTLAITAQDNGIPQKSDTTSLEILILDANDNA 904
Cdd:smart00112    1 SATDADSGENGKVTYSIlsGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1907109872   905 P 905
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
479-571 5.81e-25

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 100.45  E-value: 5.81e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  479 YVVQVPEDVAVNTAVLRVQATDRDQGQNAAIHYSIVSGNLKGQFYLHSLSGSLDVINPLDFEAIREYTLRIKAQDGGRPP 558
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGPP 80

                           90
                   ....*....|...
gi 1907109872  559 LiNSSGLVSVQVL 571
Cdd:pfam00028   81 L-SSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 497-578 2.52e-24

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 98.19  E-value: 2.52e-24
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   497 QATDRDQGQNAAIHYSIVSGNLKGQFYLHSLSGSLDVINPLDFEAIREYTLRIKAQDGGRPPLiNSSGLVSVQVLDVNDN 576
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL-SSTATVTITVLDVNDN 79


                    ..
gi 1907109872   577 AP 578
Cdd:smart00112   80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 391-472 1.71e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 95.88  E-value: 1.71e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   391 RATDGDAPSNANMRYRLLEG-AGGVFEIDARSGVVRTRAVVDREEAAEYQLLVEANDQGrnPGPLSASATVHIVVEDEND 469
Cdd:smart00112    1 SATDADSGENGKVTYSILSGnDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGG--GPPLSSTATVTITVLDVND 78


                    ...
gi 1907109872   470 NYP 472
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 706-800 3.30e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 95.46  E-value: 3.30e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  706 VYELRLNEDAAVGSSVLTLRARDRD--ANSVITYQLTGGNTRNRFALSSQSggGLITLALPLDYKQERQYVLAVTASDG- 782
Cdd:cd11304      1 SYEVSVPENAPPGTVVLTVSATDPDsgENGEVTYSIVSGNEDGLFSIDPST--GEITTAKPLDREEQSSYTLTVTATDGg 78

                           90       100
                   ....*....|....*....|
gi 1907109872  783 --TRSHTAQVFINVTDANTH 800
Cdd:cd11304     79 gpPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 283-366 3.99e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.72  E-value: 3.99e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   283 RAHDPDEGDAGRLSYQmeaLFDERSNGYFLIDAATGAVTTARSLDRETKDTHVLKVSAVDHGSPRRSAATYLTVTVSDTN 362
Cdd:smart00112    1 SATDADSGENGKVTYS---ILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVN 77


                    ....
gi 1907109872   363 DHSP 366
Cdd:smart00112   78 DNAP 81
LamG smart00282
Laminin G domain;
1480-1644 5.51e-23

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 96.25  E-value: 5.51e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  1480 TVSLAFATQDRNALLLYNGrFNEKHDFIALEIVEEQLQLTFSAGETTTTVTPQvPGGVSDGRWHSVLVQYYNkpnighlg 1559
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAG-SKGGGDYLALELRDGRLVLRYDLGSGPARLTSD-PTPLNDGQWHRVAVERNG-------- 70

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  1560 lphgpsgeKVAVVTVDDCDAAVAVHFgsyvgnyscaaqgtqsGSKKSLDLTGPLLLGGVPNLPEDFPVHSRQ-FVGCMRN 1638
Cdd:smart00282   71 --------RSVTLSVDGGNRVSGESP----------------GGLTILNLDGPLYLGGLPEDLKLPPLPVTPgFRGCIRN 126


                    ....*.
gi 1907109872  1639 LSIDGR 1644
Cdd:smart00282  127 LKVNGK 132
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 603-700 6.01e-23

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 94.34  E-value: 6.01e-23
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   603 QAVDADAGENARLQYRLVDtastivggssvdsenpaSAPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPAM 682
Cdd:smart00112    1 SATDADSGENGKVTYSILS-----------------GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPL 63

                            90
                    ....*....|....*...
gi 1907109872   683 SSSASVSITVLDVNDNDP 700
Cdd:smart00112   64 SSTATVTITVLDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 930-1012 2.99e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 92.41  E-value: 2.99e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   930 SATDRDSGPNGRLLYTFqGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPnPLSASVGIQVSVLDIND 1009
Cdd:smart00112    1 SATDADSGENGKVTYSI-LSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGP-PLSSTATVTITVLDVND 78


                    ...
gi 1907109872  1010 NPP 1012
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
265-358 3.39e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 92.36  E-value: 3.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  265 YQVSVPENEPAGTAVIELRAHDPDEGDAGRLSYQMeaLFDErSNGYFLIDAATGAVTTARSLDRETKDTHVLKVSAVDHG 344
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSI--LGGG-PGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG 77

                           90
                   ....*....|....
gi 1907109872  345 SPRRSAATYLTVTV 358
Cdd:pfam00028   78 GPPLSSTATVTITV 91
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 1037-1114 5.97e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 91.26  E-value: 5.97e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  1037 RANDPDEGPNAQIMYQIVEGNVPEVFQLDLLSGDLRALVELDFEVRRDYMLVVQAT---SAPLVSRATVHIRLLDQNDNP 1113
Cdd:smart00112    1 SATDADSGENGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATdggGPPLSSTATVTITVLDVNDNA 80


                    .
gi 1907109872  1114 P 1114
Cdd:smart00112   81 P 81
Cadherin pfam00028
Cadherin domain;
373-465 3.74e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 89.67  E-value: 3.74e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  373 YRERIRENLEVGYEVLTIRATDGDAPSNANMRYRLLEG-AGGVFEIDARSGVVRTRAVVDREEAAEYQLLVEANDQGrnP 451
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGgPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSG--G 78

                           90
                   ....*....|....
gi 1907109872  452 GPLSASATVHIVVE 465
Cdd:pfam00028   79 PPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
1023-1107 1.26e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 88.13  E-value: 1.26e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1023 VEENSPVGSVVARIRANDPDEGPNAQIMYQIVEGNVPEVFQLDLLSGDLRALVELDFEVRRDYMLVVQATSA---PLVSR 1099
Cdd:pfam00028    5 VPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSggpPLSST 84


                   ....*...
gi 1907109872 1100 ATVHIRLL 1107
Cdd:pfam00028   85 ATVTITVL 92
Cadherin pfam00028
Cadherin domain;
912-1005 1.99e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.36  E-value: 1.99e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  912 YQGSVFEDAPPSTSVLQVSATDRDSGPNGRLLYTFQGGDDGDGdFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSP 991
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGN-FRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                           90
                   ....*....|....
gi 1907109872  992 nPLSASVGIQVSVL 1005
Cdd:pfam00028   80 -PLSSTATVTITVL 92
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1485-1644 2.64e-20

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 88.25  E-value: 2.64e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1485 FATQDRNALLLYNGrfNEKHDFIALEIVEEQLQLTFSAGETTTTVTPQvPGGVSDGRWHSVLVQYYNkpnighlglphgp 1564
Cdd:pfam02210    1 FRTRQPNGLLLYAG--GGGSDFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNG------------- 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1565 sgeKVAVVTVDDCDaavavhfgsyvgnyscAAQGTQSGSKKSLDLTGPLLLGGVPN-LPEDFPVHSRQFVGCMRNLSIDG 1643
Cdd:pfam02210   65 ---NTLTLSVDGQT----------------VVSSLPPGESLLLNLNGPLYLGGLPPlLLLPALPVRAGFVGCIRDVRVNG 125


                   .
gi 1907109872 1644 R 1644
Cdd:pfam02210  126 E 126
Cadherin pfam00028
Cadherin domain;
585-693 6.47e-20

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 85.82  E-value: 6.47e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  585 FQAAVLENVPLGHSVLHIQAVDADAGENARLQYRlvdtastIVGGSSVDSenpasapdfpFQIHNSSGWITVCAELDREE 664
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYS-------ILGGGPGGN----------FRIDPDTGDISTTKPLDRES 63

                           90       100
                   ....*....|....*....|....*....
gi 1907109872  665 VEHYSFGVEAVDHGSPAMSSSASVSITVL 693
Cdd:pfam00028   64 IGEYELTVEATDSGGPPLSSTATVTITVL 92
Laminin_G_1 pfam00054
Laminin G domain;
1485-1647 2.19e-16

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 77.36  E-value: 2.19e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1485 FATQDRNALLLYNGRfNEKHDFIALEIVEEQLQLTFSAGETTTTVTPqvPGGVSDGRWHSVLVqYYNKpnighlglphgp 1564
Cdd:pfam00054    1 FRTTEPSGLLLYNGT-QTERDFLALELRDGRLEVSYDLGSGAAVVRS--GDKLNDGKWHSVEL-ERNG------------ 64

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1565 sgeKVAVVTVDDCdaavAVHFGSYVgnyscaaqgtqSGSKKSLDLTGPLLLGGVPNL---PEDFPvHSRQFVGCMRNLSI 1641
Cdd:pfam00054   65 ---RSGTLSVDGE----ARPTGESP-----------LGATTDLDVDGPLYVGGLPSLgvkKRRLA-ISPSFDGCIRDVIV 125


                   ....*.
gi 1907109872 1642 DGRIVD 1647
Cdd:pfam00054  126 NGKPLD 131
Cadherin pfam00028
Cadherin domain;
707-795 1.06e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 1.06e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  707 YELRLNEDAAVGSSVLTLRARDRD--ANSVITYQLTGGNTRNRFALSSQSGggLITLALPLDYKQERQYVLAVTASDG-- 782
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDlgPNGRIFYSILGGGPGGNFRIDPDTG--DISTTKPLDRESIGEYELTVEATDSgg 78

                           90
                   ....*....|....
gi 1907109872  783 -TRSHTAQVFINVT 795
Cdd:pfam00028   79 pPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 725-802 5.24e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 68.92  E-value: 5.24e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872   725 RARDRD--ANSVITYQLTGGNTRNRFALSSQSGggLITLALPLDYKQERQYVLAVTASDG---TRSHTAQVFINVTDANT 799
Cdd:smart00112    1 SATDADsgENGKVTYSILSGNDDGLFSIDPETG--EITTTKPLDREEQPEYTLTVEATDGggpPLSSTATVTITVLDVND 78


                    ...
gi 1907109872   800 HRP 802
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 1132-1213 2.84e-10

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 58.86  E-value: 2.84e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1132 NSFPSGVIGRIPAHDPDLSD--SLNYTFLQGNELSLLLLDPATGELQLSRDLDNNRPLEALMEVSVSD-GIHSVTALCTL 1208
Cdd:cd11304      9 NAPPGTVVLTVSATDPDSGEngEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDgGGPPLSSTATV 88


                   ....*
gi 1907109872 1209 RVTII 1213
Cdd:cd11304     89 TITVL 93
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1379-1414 6.08e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 53.02  E-value: 6.08e-09
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1907109872 1379 IDLCYS-NPCGANGRCRSREGGYTCECFEDFTGEHCQ 1414
Cdd:cd00054      2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1666-1700 7.69e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 7.69e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907109872 1666 NFCD-GTSCQNGGTCVNRWNTYLCECPLRFGGKNCE 1700
Cdd:cd00054      3 DECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1422-1456 9.08e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.64  E-value: 9.08e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907109872 1422 CASG-VCKNGGTCVNLlIGGFHCVCPPGeYEHPYCE 1456
Cdd:cd00054      5 CASGnPCQNGGTCVNT-VGSYRCSCPPG-YTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1422-1456 1.30e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 1.30e-08
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907109872  1422 CASG-VCKNGGTCVNLlIGGFHCVCPPGEYEHPYCE 1456
Cdd:smart00179    5 CASGnPCQNGGTCVNT-VGSYRCECPPGYTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1382-1412 6.68e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.99  E-value: 6.68e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907109872 1382 CYSNPCGANGRCRSREGGYTCECFEDFTGEH 1412
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1668-1698 7.59e-07

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 46.99  E-value: 7.59e-07
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1907109872 1668 CDGTSCQNGGTCVNRWNTYLCECPLRFGGKN 1698
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1673-1700 1.02e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.86  E-value: 1.02e-06
                            10        20
                    ....*....|....*....|....*....
gi 1907109872  1673 CQNGGTCVNRWNTYLCECPLRF-GGKNCE 1700
Cdd:smart00179   11 CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1378-1414 1.49e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.47  E-value: 1.49e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1907109872  1378 EIDLCYS-NPCGANGRCRSREGGYTCECFEDFT-GEHCQ 1414
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1384-1414 2.10e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 45.93  E-value: 2.10e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1907109872 1384 SNPCGANGRCRSREGGYTCECFEDFTGE-HCQ 1414
Cdd:cd00053      5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1422-1456 2.14e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 45.93  E-value: 2.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1907109872 1422 CA-SGVCKNGGTCVNLlIGGFHCVCPPGEYEHPYCE 1456
Cdd:cd00053      2 CAaSNPCSNGGTCVNT-PGSYRCVCPPGYTGDRSCE 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1673-1700 7.17e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 44.39  E-value: 7.17e-06
                           10        20
                   ....*....|....*....|....*....
gi 1907109872 1673 CQNGGTCVNRWNTYLCECPLRF-GGKNCE 1700
Cdd:cd00053      8 CSNGGTCVNTPGSYRCVCPPGYtGDRSCE 36
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1427-1448 2.32e-05

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 42.71  E-value: 2.32e-05
                           10        20
                   ....*....|....*....|..
gi 1907109872 1427 CKNGGTCVNLlIGGFHCVCPPG 1448
Cdd:pfam12661    1 CQNGGTCVDG-VNGYKCQCPPG 21
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1422-1448 3.61e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 42.37  E-value: 3.61e-05
                           10        20
                   ....*....|....*....|....*..
gi 1907109872 1422 CASGVCKNGGTCVNLLiGGFHCVCPPG 1448
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEG 26
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1673-1691 3.85e-05

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 41.94  E-value: 3.85e-05
                           10
                   ....*....|....*....
gi 1907109872 1673 CQNGGTCVNRWNTYLCECP 1691
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCP 19
EGF_CA pfam07645
Calcium-binding EGF domain;
1422-1448 5.51e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.84  E-value: 5.51e-05
                           10        20
                   ....*....|....*....|....*....
gi 1907109872 1422 CASG--VCKNGGTCVNLlIGGFHCVCPPG 1448
Cdd:pfam07645    5 CATGthNCPANTVCVNT-IGSFECRCPDG 32
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 638-698 7.24e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.49  E-value: 7.24e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1907109872  638 ASAPDFPFQIHNSSGWITVCAELDREEVEHYSFGVEAVDHGSPAMSSSASVSITVLDVNDN 698
Cdd:cd00031     38 KEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
EGF smart00181
Epidermal growth factor-like domain;
1384-1414 5.14e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 39.04  E-value: 5.14e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1907109872  1384 SNPCGaNGRCRSREGGYTCECFEDFTG-EHCQ 1414
Cdd:smart00181    5 GGPCS-NGTCINTPGSYTCSCPPGYTGdKRCE 35
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 268-364 6.00e-04

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 40.79  E-value: 6.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  268 SVPENEPAGTAVIELRAhdpDEGDAGRLSYQMEALFDERSNGYFLIDAATGAVTTARSLDRETKDTHVLKVSAVDHGSPR 347
Cdd:cd00031      5 SAVEGRSRGSFRVSIPT---DLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                           90
                   ....*....|....*..
gi 1907109872  348 RSAATYLTVTVSDTNDH 364
Cdd:cd00031     82 PQTSSVFSIEVYDENDN 98
EGF smart00181
Epidermal growth factor-like domain;
1422-1456 1.43e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.88  E-value: 1.43e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1907109872  1422 CAS-GVCKNGgTCVNLlIGGFHCVCPPGEYEHPYCE 1456
Cdd:smart00181    2 CASgGPCSNG-TCINT-PGSYTCSCPPGYTGDKRCE 35
Stig1 pfam04885
Stigma-specific protein, Stig1; This family represents the Stig1 cysteine rich plant protein. ...
 1382-1450 1.96e-03

Stigma-specific protein, Stig1; This family represents the Stig1 cysteine rich plant protein. The STIG1 gene is developmentally regulated and expressed specifically in the stigmatic secretory zone.


Pssm-ID: 461466  Cd Length: 136  Bit Score: 40.44  E-value: 1.96e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872 1382 CYSNP--CGANGrcrsrEGGYTCeCfedftGEHCqVNVRSGR--CasGVCKN---------GGTCVNLLIGGFHC----- 1443
Cdd:pfam04885   55 CDKDPeiCRAKG-----SPGPTC-C-----KKKC-VDVLTDRnnC--GACGKkckfgetccGGRCVNLNFDKRHCgkcnn 120


                   ....*..
gi 1907109872 1444 VCPPGEY 1450
Cdd:pfam04885  121 RCKKGEF 127
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 914-1010 2.03e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 39.25  E-value: 2.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907109872  914 GSVFEDAPPSTSVLQVsATDRDSGPNGRLLYTFQGGDDGDGDFYIEPTSGVIRTQRRLDRENVAVYNLWALAVDRGSPNP 993
Cdd:cd00031      4 GSAVEGRSRGSFRVSI-PTDLIASSGEIIKISAAGKEALPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVP 82

                           90
                   ....*....|....*..
gi 1907109872  994 LSASVGiQVSVLDINDN 1010
Cdd:cd00031     83 QTSSVF-SIEVYDENDN 98
EGF smart00181
Epidermal growth factor-like domain;
1673-1700 5.90e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.96  E-value: 5.90e-03
                            10        20
                    ....*....|....*....|....*....
gi 1907109872  1673 CQNGgTCVNRWNTYLCECPLRF-GGKNCE 1700
Cdd:smart00181    8 CSNG-TCINTPGSYTCSCPPGYtGDKRCE 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH