|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1228-1632 |
6.79e-16 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 85.38 E-value: 6.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1228 QALGITPTPQPITLTPEQAQALGITPTPQPTTLTPEQTQALGITPTPQPITLTPEQAQALGIT-PTPQPITLTPEQTQAL 1306
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdPPPPPPTPEPAPHALV 2716
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1307 GITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPqPITLTPEQAQALGITPTPQPITLTPEQAQALGITP 1386
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP-PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR 2795
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1387 TPQPITLTPEQAQALGITPTPqpiTLTPEQTQALGITPTPQPITLTPEQaqalgiTPTPQPITLTPEQVQALGITPTPQP 1466
Cdd:PHA03247 2796 ESLPSPWDPADPPAAVLAPAA---ALPPAASPAGPLPPPTSAQPTAPPP------PPGPPPPSLPLGGSVAPGGDVRRRP 2866
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1467 itlTPEQAQALGITPTPQPITLTPEQAqalgITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLT 1546
Cdd:PHA03247 2867 ---PSRSPAAKPAAPARPPVRRLARPA----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRP 2939
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1547 PelvqalgitPTPQPITLTPEQAQALGITPTPQPTTLSPEQaqalgitpTPQPITLTPEQAQALgitPTPQPTTLSPEQA 1626
Cdd:PHA03247 2940 Q---------PPLAPTTDPAGAGEPSGAVPQPWLGALVPGR--------VAVPRFRVPQPAPSR---EAPASSTPPLTGH 2999
|
....*.
gi 1907114278 1627 QALGIS 1632
Cdd:PHA03247 3000 SLSRVS 3005
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1329-1628 |
2.79e-10 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 66.33 E-value: 2.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1329 PTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPItltPEQAQALGITPTPQ 1408
Cdd:pfam03154 180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---PSPHPPLQPMTQPP 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1409 PITLTPEQtqalgitPTPQPITLTPeqaqalgITPTPQPITLTPEQVQALGitpTPQPITLTPEQAQALGitpTPQPITL 1488
Cdd:pfam03154 257 PPSQVSPQ-------PLPQPSLHGQ-------MPPMPHSLQTGPSHMQHPV---PPQPFPLTPQSSQSQV---PPGPSPA 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1489 TPEQAQALGITPTPQPITLTPEQTQALGITPTPQPIT-LTPEQAQALGITPTPQPITLTPELVqalGITPTPQPITLTPE 1567
Cdd:pfam03154 317 APGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhIKPPPTTPIPQLPNPQSHKHPPHLS---GPSPFQMNSNLPPP 393
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907114278 1568 QA-QALGITPTPQPTTLSPEQAQALgitptPQPITLTPEQAQALGITPTPqptTLSPEQAQA 1628
Cdd:pfam03154 394 PAlKPLSSLSTHHPPSAHPPPLQLM-----PQSQQLPPPPAQPPVLTQSQ---SLPPPAASH 447
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2430-2775 |
2.71e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.32 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2430 QPAQAFPSPFTLEKPATLATSTDRLSQRWKDSYPASIPLQALRPSPTQAPFTPTTSLgigslldsekpwmsptyrqtltd 2509
Cdd:PHA03247 2642 PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL----------------------- 2698
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2510 rgqdvlAQPLAPETPPSLRQLLAPGAPPTPGPPLGPRHFFKPrvpPTSGEVPGLVSGGSAaheeLPMSRTTPLQPPEWQG 2589
Cdd:PHA03247 2699 ------ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPA---LPAAPAPPAVPAGPA----TPGGPARPARPPTTAG 2765
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2590 PSRLIPEQGfmPAISSIPLHPFTAEALPTPGRPQRSSKAKPLKPKSARGLPNVTLGFETSQA-PFPIEKTQIPKTPDTSE 2668
Cdd:PHA03247 2766 PPAPAPPAA--PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgPLPPPTSAQPTAPPPPP 2843
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2669 QTQALQDALG--VQPFGIF-------QPYGTSSGIARSQSPLIDEKALSREKPGTPLPSLTTQLPQTPQISTSEKGQ--- 2736
Cdd:PHA03247 2844 GPPPPSLPLGgsVAPGGDVrrrppsrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQpqp 2923
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1907114278 2737 ------KPWLPPIDKPWTPTPVSSTREAKMIVSPTDQHPEDGYVV 2775
Cdd:PHA03247 2924 ppppqpQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
|
|
| SP2_N |
cd22540 |
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ... |
1264-1615 |
7.62e-05 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.
Pssm-ID: 411776 [Multi-domain] Cd Length: 511 Bit Score: 48.38 E-value: 7.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1264 QTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQA 1343
Cdd:cd22540 122 TNQQYQISPQIQAAGQINNSGQIQIIPGTNQAIITPVQVLQQPQQAHKPVPIKPAPLQTSNTNSASLQVPGNVIKLQSGG 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1344 LGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPitlTPEQAQALGITPTPQPI-----TLTPEQTQ 1418
Cdd:cd22540 202 NVALTLPVNNLVGTQDGATQLQLAAAPSKPSKKIRKKSAQAAQPAVT---VAEQVETVLIETTADNIiqagnNLLIVQSP 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1419 ALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQVQALGITP-----TPQPITLTPEQAQALGITPTPQPITLTPEQA 1493
Cdd:cd22540 279 GTGQPAVLQQVQVLQPKQEQQVVQIPQQALRVVQAASATLPTVPqkplqNIQIQNSEPTPTQVYIKTPSGEVQTVLLQEA 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1494 QALGITPTPQPITLTPEQTQALGiTPTPQPITLTPEQAQALGITPTPQPITLTPELVQALGITPTPQPITLTPEQAQALG 1573
Cdd:cd22540 359 PAATATPSSSTSTVQQQVTANNG-TGTSKPNYNVRKERTLPKIAPAGGIISLNAAQLAAAAQAIQTININGVQVQGVPVT 437
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1907114278 1574 ITPTPQPTTLSPEQAQALGIT---PTPQPITLTPEQAQALGITPT 1615
Cdd:cd22540 438 ITNAGGQQQLTVQTVSSNNLTisgLSPTQIQLQMEQALEIETQPG 482
|
|
| MRS6 |
COG5043 |
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]; |
25-255 |
5.55e-04 |
|
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
Pssm-ID: 227376 [Multi-domain] Cd Length: 2552 Bit Score: 46.03 E-value: 5.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 25 LATLRKPISNRDNPL-SLQFEIPASV---QSVIHKIEESHIFRAKEEVIWRLTEIMSNVELIMTRYNIDS---MSPGRKG 97
Cdd:COG5043 47 LDKLGLPIEVTSGLIgTLTLEIPWSSlknKPVEIYIEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSweiLRETLEE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 98 SSSESQKKKRKAFLEKIATVMT--------NVDLR-ERTLSKILSWLEEWNLILSEVSAINMDDyyHWT-----VKMELI 163
Cdd:COG5043 127 SSSSPNISRKQSFIESLITKLIdniqiyieDIHLRfEDNLSADLEGPYSFGLTLYSLRATSTDA--SWTeyfvsTDSSCI 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 164 -------------PDTLKRISK-NVDSLIQMALLLVEEKKRAKKR-ILA--RGTLWkawkdRAIKRPATAQALRLD-QMI 225
Cdd:COG5043 205 hklitldyfsiywCEISPCITTeDIDSYLENFQPMIAEKSPAYNEyILKpvRGTAK-----VSINKLPTDEIPRLRgQLS 279
|
250 260 270
....*....|....*....|....*....|....*.
gi 1907114278 226 FDQIGL---NAKVSEIQGMLQEL---IGTAMFSKLE 255
Cdd:COG5043 280 VEEFSIslsDHMYYSLLGVLDYLqvvMKQQKFLKYR 315
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1228-1632 |
6.79e-16 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 85.38 E-value: 6.79e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1228 QALGITPTPQPITLTPEQAQALGITPTPQPTTLTPEQTQALGITPTPQPITLTPEQAQALGIT-PTPQPITLTPEQTQAL 1306
Cdd:PHA03247 2637 EPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdPPPPPPTPEPAPHALV 2716
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1307 GITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPqPITLTPEQAQALGITPTPQPITLTPEQAQALGITP 1386
Cdd:PHA03247 2717 SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARP-PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESR 2795
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1387 TPQPITLTPEQAQALGITPTPqpiTLTPEQTQALGITPTPQPITLTPEQaqalgiTPTPQPITLTPEQVQALGITPTPQP 1466
Cdd:PHA03247 2796 ESLPSPWDPADPPAAVLAPAA---ALPPAASPAGPLPPPTSAQPTAPPP------PPGPPPPSLPLGGSVAPGGDVRRRP 2866
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1467 itlTPEQAQALGITPTPQPITLTPEQAqalgITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLT 1546
Cdd:PHA03247 2867 ---PSRSPAAKPAAPARPPVRRLARPA----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRP 2939
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1547 PelvqalgitPTPQPITLTPEQAQALGITPTPQPTTLSPEQaqalgitpTPQPITLTPEQAQALgitPTPQPTTLSPEQA 1626
Cdd:PHA03247 2940 Q---------PPLAPTTDPAGAGEPSGAVPQPWLGALVPGR--------VAVPRFRVPQPAPSR---EAPASSTPPLTGH 2999
|
....*.
gi 1907114278 1627 QALGIS 1632
Cdd:PHA03247 3000 SLSRVS 3005
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1234-1635 |
2.97e-15 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 83.06 E-value: 2.97e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1234 PTPQPITLTPEQAqaLGITPTPQPTTLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQ 1313
Cdd:PHA03247 2569 PPPRPAPRPSEPA--VTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTV 2646
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1314 PITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGIT-PTPQPITLTPEQAQALGITPTPQPIT 1392
Cdd:PHA03247 2647 PPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdPPPPPPTPEPAPHALVSATPLPPGPA 2726
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1393 LTPEQAQALGITPTPQPITLTPEQTQALGITPTPqPITLTPEQAQALGITPTPQPITLTPEQVQALGITPTPQPITLTPE 1472
Cdd:PHA03247 2727 AARQASPALPAAPAPPAVPAGPATPGGPARPARP-PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPA 2805
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1473 QAQALGITPTPqpiTLTPEQAQALGITPTPQPITLTPEQTqalgitPTPQPITLTPEQAQALG----ITPTPQPITLTPE 1548
Cdd:PHA03247 2806 DPPAAVLAPAA---ALPPAASPAGPLPPPTSAQPTAPPPP------PGPPPPSLPLGGSVAPGgdvrRRPPSRSPAAKPA 2876
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1549 L--------VQALGITPTPQPITLTPEQAQALGITPTPQPTTLSPEQAQAlgitPTPQPITLTPEQAQalgitPTPQPTT 1620
Cdd:PHA03247 2877 AparppvrrLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPP----PQPQPPPPPPPRPQ-----PPLAPTT 2947
|
410
....*....|....*
gi 1907114278 1621 LSPEQAQALGISLIP 1635
Cdd:PHA03247 2948 DPAGAGEPSGAVPQP 2962
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1272-1649 |
1.62e-14 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 80.75 E-value: 1.62e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1272 PTPQPITLTPEQA-QALGITPTPQPITLTPeqtQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTP 1350
Cdd:PHA03247 2569 PPPRPAPRPSEPAvTSRARRPDAPPQSARP---RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPT 2645
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1351 QPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGIT-PTPQPITLTPEQTQALGITPTPQPI 1429
Cdd:PHA03247 2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdPPPPPPTPEPAPHALVSATPLPPGP 2725
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1430 TLTPEQAQALGITPTPQPITLTPEQVQALGITPTPqPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPITLTP 1509
Cdd:PHA03247 2726 AAARQASPALPAAPAPPAVPAGPATPGGPARPARP-PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDP 2804
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1510 EQTQALGITPTPqpiTLTPEQAQALGITPTPQPITLTPELvqalgiTPTPQPITLTPEQAQALG---------ITPTPQP 1580
Cdd:PHA03247 2805 ADPPAAVLAPAA---ALPPAASPAGPLPPPTSAQPTAPPP------PPGPPPPSLPLGGSVAPGgdvrrrppsRSPAAKP 2875
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907114278 1581 TTLSPEQAQALG---ITPTPQPITLTPEQAQALGITPTPQPTTLSPEQAQALGISLIPKQQEISLSPEQAQA 1649
Cdd:PHA03247 2876 AAPARPPVRRLArpaVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT 2947
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1329-1628 |
2.79e-10 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 66.33 E-value: 2.79e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1329 PTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPItltPEQAQALGITPTPQ 1408
Cdd:pfam03154 180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---PSPHPPLQPMTQPP 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1409 PITLTPEQtqalgitPTPQPITLTPeqaqalgITPTPQPITLTPEQVQALGitpTPQPITLTPEQAQALGitpTPQPITL 1488
Cdd:pfam03154 257 PPSQVSPQ-------PLPQPSLHGQ-------MPPMPHSLQTGPSHMQHPV---PPQPFPLTPQSSQSQV---PPGPSPA 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1489 TPEQAQALGITPTPQPITLTPEQTQALGITPTPQPIT-LTPEQAQALGITPTPQPITLTPELVqalGITPTPQPITLTPE 1567
Cdd:pfam03154 317 APGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhIKPPPTTPIPQLPNPQSHKHPPHLS---GPSPFQMNSNLPPP 393
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1907114278 1568 QA-QALGITPTPQPTTLSPEQAQALgitptPQPITLTPEQAQALGITPTPqptTLSPEQAQA 1628
Cdd:pfam03154 394 PAlKPLSSLSTHHPPSAHPPPLQLM-----PQSQQLPPPPAQPPVLTQSQ---SLPPPAASH 447
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1227-1549 |
1.27e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 64.57 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1227 AQALGITPTPQPITLTPEQAQALGITPTPQPTTLTPEQTQALGITPTPQPiTLTPEQAQALGITPTPQPITLTPEQTQAL 1306
Cdd:PHA03247 2732 SPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPR-RLTRPAVASLSESRESLPSPWDPADPPAA 2810
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1307 GITPTPqpiTLTPEQAQALGITPTPQPITLTPEQtqalgiTPTPQPITLTPEQAQALGITPTPQPitlTPEQAQALGITP 1386
Cdd:PHA03247 2811 VLAPAA---ALPPAASPAGPLPPPTSAQPTAPPP------PPGPPPPSLPLGGSVAPGGDVRRRP---PSRSPAAKPAAP 2878
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1387 TPQPITLTPEQAqalgITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQAlgitPTPQPITLTPEQVQalgitPTPQP 1466
Cdd:PHA03247 2879 ARPPVRRLARPA----VSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPP----PQPQPPPPPPPRPQ-----PPLAP 2945
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1467 ITLTPEQAQALGITPTPQPITLTPEQAQAL-GITPTPQPITLTPEQTQAlgiTPTPQPITLTPEQAQ--ALGITPTPQPI 1543
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQPWLGALVPGRVAVPrFRVPQPAPSREAPASSTP---PLTGHSLSRVSSWASslALHEETDPPPV 3022
|
....*.
gi 1907114278 1544 TLTPEL 1549
Cdd:PHA03247 3023 SLKQTL 3028
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1367-1656 |
1.82e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 63.63 E-value: 1.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1367 PTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPItltPEQAQALGITPTPQ 1446
Cdd:pfam03154 180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---PSPHPPLQPMTQPP 256
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1447 PITLTPEQvqalgitPTPQPITLTPeqaqalgITPTPQPITLTPEQAQALGitpTPQPITLTPEQTQALGitpTPQPITL 1526
Cdd:pfam03154 257 PPSQVSPQ-------PLPQPSLHGQ-------MPPMPHSLQTGPSHMQHPV---PPQPFPLTPQSSQSQV---PPGPSPA 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1527 TPEQAQALGITPTPQPITLTPELVQALGITPTPQPIT-LTPEQAQALGITPTPQPTTLSPEQAqalGITPTPQPITLTPE 1605
Cdd:pfam03154 317 APGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPhIKPPPTTPIPQLPNPQSHKHPPHLS---GPSPFQMNSNLPPP 393
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 1907114278 1606 QAqalgITPTPQPTTLSPEQAQALGISLIPKQQEISLSPeqAQALGLTLTP 1656
Cdd:pfam03154 394 PA----LKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPP--AQPPVLTQSQ 438
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1158-1507 |
3.19e-09 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 63.42 E-value: 3.19e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1158 PTPQPITFTPEQTQALGITPTPqlitLTPEQAKALANTLTAEQVSLSPQQAEALGITPTPQPTTLTP---EQAQALGITP 1234
Cdd:PHA03247 2701 PPPPPPTPEPAPHALVSATPLP----PGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTagpPAPAPPAAPA 2776
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1235 TPQPITLTPEQAQALGITPTPQPTTLTPEQTQALGITPTP-QPITLTPEQAQALGITPTPQPITLTPEqtqalgitptPQ 1313
Cdd:PHA03247 2777 AGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAaLPPAASPAGPLPPPTSAQPTAPPPPPG----------PP 2846
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1314 PITLTPEQAQALGITPTPQPitlTPEQTQALGITPTPQPITLTPEQAqalgITPTPQPITLTPEQAQALGITPTPQPITL 1393
Cdd:PHA03247 2847 PPSLPLGGSVAPGGDVRRRP---PSRSPAAKPAAPARPPVRRLARPA----VSRSTESFALPPDQPERPPQPQAPPPPQP 2919
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1394 TPEQAQAlgitPTPQPITLTPEQTQalgitPTPQPITLTPEQAQALGITPTPQPITLTPEQVQAL-GITPTPQPITLTPE 1472
Cdd:PHA03247 2920 QPQPPPP----PQPQPPPPPPPRPQ-----PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPrFRVPQPAPSREAPA 2990
|
330 340 350
....*....|....*....|....*....|....*..
gi 1907114278 1473 QAQAlgiTPTPQPITLTPEQAQ--ALGITPTPQPITL 1507
Cdd:PHA03247 2991 SSTP---PLTGHSLSRVSSWASslALHEETDPPPVSL 3024
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1265-1624 |
5.31e-09 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 62.09 E-value: 5.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1265 TQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQAL 1344
Cdd:pfam03154 192 TQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSL 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1345 --GITPTPQPITLTPEQAQALGitpTPQPITLTPEQAQALGitpTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGI 1422
Cdd:pfam03154 272 hgQMPPMPHSLQTGPSHMQHPV---PPQPFPLTPQSSQSQV---PPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPL 345
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1423 TPTPQPIT-LTPEQAQALGITPTPQPITLTPeqvQALGITPTPQPITLTPEQA-QALGITPTPQPITLTPEQAQalgITP 1500
Cdd:pfam03154 346 PPAPLSMPhIKPPPTTPIPQLPNPQSHKHPP---HLSGPSPFQMNSNLPPPPAlKPLSSLSTHHPPSAHPPPLQ---LMP 419
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1501 TPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPELVQAlgitPTPQPITLTPEQAQALGITPTPQP 1580
Cdd:pfam03154 420 QSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGG----PPPITPPSGPPTSTSSAMPGIQPP 495
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1907114278 1581 TTLSPEQAQALGITPT----PQPITLTPEQAQALGITPTPQPTTLSPE 1624
Cdd:pfam03154 496 SSASVSSSGPVPAAVScplpPVQIKEEALDEAEEPESPPPPPRSPSPE 543
|
|
| DUF5585 |
pfam17823 |
Family of unknown function (DUF5585); This is a family of unknown function found in chordata. |
1263-1649 |
5.15e-07 |
|
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
Pssm-ID: 465521 [Multi-domain] Cd Length: 506 Bit Score: 55.35 E-value: 5.15e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1263 EQTQALGITPTPQPITLTpEQAQALGITPTPQPITLTPEQTQAlgITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQ 1342
Cdd:pfam17823 56 EQ*NFCAATAAPAPVTLT-KGTSAAHLNSTEVTAEHTPHGTDL--SEPATREGAADGAASRALAAAASSSPSSAAQSLPA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1343 ALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGI 1422
Cdd:pfam17823 133 AIAALPSEAFSAPRAAACRANASAAPRAAIAAASAPHAASPAPRTAASSTTAASSTTAASSAPTTAASSAPATLTPARGI 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1423 TpTPQPITLTPEQAQALGITPTPQPITLTPEQVqalgiTPTPQPITLTPEQAQALGITPTPQPITLTPEQAQalgitpTP 1502
Cdd:pfam17823 213 S-TAATATGHPAAGTALAAVGNSSPAAGTVTAA-----VGTVTPAALATLAAAAGTVASAAGTINMGDPHAR------RL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1503 QPITLTPEQTQALGITPTPQPitltpeQAQAlgitPTPQPITLTPELVQALGITPTPQPITLTPEQAQALGITPTPQPTT 1582
Cdd:pfam17823 281 SPAKHMPSDTMARNPAAPMGA------QAQG----PIIQVSTDQPVHNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTT 350
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1907114278 1583 lspEQAQALGITPTPQPITLTPEQAQALGITPTPQPTTLSPEQ-AQALGISLIPKQQEISLSPEQAQA 1649
Cdd:pfam17823 351 ---TKAQAKEPSASPVPVLHTSMIPEVEATSPTTQPSPLLPTQgAAGPGILLAPEQVATEATAGTASA 415
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1158-1531 |
4.33e-06 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 52.85 E-value: 4.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1158 PTPQPITFTPEQTQALGITPTPQLITLTPEQAKALANTLTAEQVSLSPQQAEALGITPTPQPTTLTPEQAQALGITPTPQ 1237
Cdd:pfam03154 180 AASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMTQPPPPS 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1238 PITLTPEQAQALGITPTPQPTTLTPEQTQALGITPtPQPITLTPEQAQALGitpTPQPITLTPEQTQALGITPTPQPITL 1317
Cdd:pfam03154 260 QVSPQPLPQPSLHGQMPPMPHSLQTGPSHMQHPVP-PQPFPLTPQSSQSQV---PPGPSPAAPGQSQQRIHTPPSQSQLQ 335
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1318 TPEQAQALGITPTPQPIT-LTPEQTQALGITPTPQPITLTPEQAqalGITPTPQPITLTPEQA-QALGITPT-------P 1388
Cdd:pfam03154 336 SQQPPREQPLPPAPLSMPhIKPPPTTPIPQLPNPQSHKHPPHLS---GPSPFQMNSNLPPPPAlKPLSSLSThhppsahP 412
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1389 QPITLTPeQAQALGITPTpQPITLTPEQTQALGITPTPQPITLTPEQAQA----LGITPTPQPITLTPEQVQAlgITPTP 1464
Cdd:pfam03154 413 PPLQLMP-QSQQLPPPPA-QPPVLTQSQSLPPPAASHPPTSGLHQVPSQSpfpqHPFVPGGPPPITPPSGPPT--STSSA 488
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1465 QPITLTPEQAQALGITPTPQPIT--LTPEQAQALGITPTPQPITLTPEQTqalgiTPTPQP-ITLTPEQA 1531
Cdd:pfam03154 489 MPGIQPPSSASVSSSGPVPAAVScpLPPVQIKEEALDEAEEPESPPPPPR-----SPSPEPtVVNTPSHA 553
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2430-2775 |
2.71e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 50.32 E-value: 2.71e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2430 QPAQAFPSPFTLEKPATLATSTDRLSQRWKDSYPASIPLQALRPSPTQAPFTPTTSLgigslldsekpwmsptyrqtltd 2509
Cdd:PHA03247 2642 PPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSL----------------------- 2698
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2510 rgqdvlAQPLAPETPPSLRQLLAPGAPPTPGPPLGPRHFFKPrvpPTSGEVPGLVSGGSAaheeLPMSRTTPLQPPEWQG 2589
Cdd:PHA03247 2699 ------ADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPA---LPAAPAPPAVPAGPA----TPGGPARPARPPTTAG 2765
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2590 PSRLIPEQGfmPAISSIPLHPFTAEALPTPGRPQRSSKAKPLKPKSARGLPNVTLGFETSQA-PFPIEKTQIPKTPDTSE 2668
Cdd:PHA03247 2766 PPAPAPPAA--PAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAgPLPPPTSAQPTAPPPPP 2843
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2669 QTQALQDALG--VQPFGIF-------QPYGTSSGIARSQSPLIDEKALSREKPGTPLPSLTTQLPQTPQISTSEKGQ--- 2736
Cdd:PHA03247 2844 GPPPPSLPLGgsVAPGGDVrrrppsrSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQpqp 2923
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1907114278 2737 ------KPWLPPIDKPWTPTPVSSTREAKMIVSPTDQHPEDGYVV 2775
Cdd:PHA03247 2924 ppppqpQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALV 2968
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
1381-1647 |
2.78e-05 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 49.91 E-value: 2.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1381 ALGITPTPQPITLTPEQA----QALGITPTPQPITLTPeqtqALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQVQ 1456
Cdd:pfam05109 395 GLGTAPKTLIITRTATNAttttHKVIFSKAPESTTTSP----TLNTTGFAAPNTTTGLPSSTHVPTNLTAPASTGPTVST 470
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1457 ALGITPTPQPITltpeqAQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQ---- 1532
Cdd:pfam05109 471 ADVTSPTPAGTT-----SGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKtspt 545
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1533 ALGITPTPQPITLTPELVqalgiTPTPQPITLTPEQAQALGITPTPQPTTLSPEQAQ----------ALGITPTPQPITL 1602
Cdd:pfam05109 546 SAVTTPTPNATSPTPAVT-----TPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGEtspqanttnhTLGGTSSTPVVTS 620
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 1907114278 1603 TPEQAQALGITPTPQPTTLSPEQaqalgISLIPKQQEISLSPEQA 1647
Cdd:pfam05109 621 PPKNATSAVTTGQHNITSSSTSS-----MSLRPSSISETLSPSTS 660
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
1351-1637 |
3.26e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 49.68 E-value: 3.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1351 QPITLTPEQAQALgitPTPQPitlTPEQAQALGITPTPQPITLTPEQAQalgiTPTPQPitlTPEQTQALGITPTPQPIT 1430
Cdd:PHA03378 552 EPASTEPVHDQLL---PAPGL---GPLQIQPLTSPTTSQLASSAPSYAQ----TPWPVP---HPSQTPEPPTTQSHIPET 618
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1431 LTPEQaqalgiTPTP-QPITLTPEQVQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITpTPQPITLTP 1509
Cdd:PHA03378 619 SAPRQ------WPMPlRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPYQPSPTGAN-TMLPIQWAP 691
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1510 EQTQALGITPTP-QPITLTPEQAQALGITPTP-QPITLTPELVQALGITPTPQPitlTPEQAQALGITPTPQPTTLSPEQ 1587
Cdd:PHA03378 692 GTMQPPPRAPTPmRPPAAPPGRAQRPAAATGRaRPPAAAPGRARPPAAAPGRAR---PPAAAPGRARPPAAAPGRARPPA 768
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1588 AQALGITPTPQPITLTPEQAQALGiTPTPQPttlsPEQAQALGISLIPKQ 1637
Cdd:PHA03378 769 AAPGAPTPQPPPQAPPAPQQRPRG-APTPQP----PPQAGPTSMQLMPRA 813
|
|
| SP2_N |
cd22540 |
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins ... |
1264-1615 |
7.62e-05 |
|
N-terminal domain of transcription factor Specificity Protein (SP) 2; Specificity Proteins (SPs) are transcription factors that are involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. SP2 contains the least conserved DNA-binding domain within the SP subfamily of proteins, and its DNA sequence specificity differs from the other SP proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate, or in some cases, repress expression from different promoters. The transcription factor SP2 serves as a paradigm for indirect genomic binding. It does not require its DNA-binding domain for genomic DNA binding and occupies target promoters independently of whether they contain a cognate DNA-binding motif. SP2 belongs to a family of proteins, called the SP/Kruppel or Krueppel-like Factor (KLF) family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. SP factors preferentially bind GC boxes, while KLFs bind CACCC boxes. Another characteristic hallmark of SP factors is the presence of the Buttonhead (BTD) box CXCPXC, just N-terminal to the zinc fingers. The function of the BTD box is unknown, but it is thought to play an important physiological role. Another feature of most SP factors is the presence of a conserved amino acid stretch, the so-called SP box, located close to the N-terminus. SP factors may be separated into three groups based on their domain architecture and the similarity of their N-terminal transactivation domains: SP1-4, SP5, and SP6-9. The transactivation domains between the three groups are not homologous to one another. SP1-4 have similar N-terminal transactivation domains characterized by glutamine-rich regions, which, in most cases, have adjacent serine/threonine-rich regions. This model represents the N-terminal domain of SP2.
Pssm-ID: 411776 [Multi-domain] Cd Length: 511 Bit Score: 48.38 E-value: 7.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1264 QTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQA 1343
Cdd:cd22540 122 TNQQYQISPQIQAAGQINNSGQIQIIPGTNQAIITPVQVLQQPQQAHKPVPIKPAPLQTSNTNSASLQVPGNVIKLQSGG 201
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1344 LGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGITPTPQPitlTPEQAQALGITPTPQPI-----TLTPEQTQ 1418
Cdd:cd22540 202 NVALTLPVNNLVGTQDGATQLQLAAAPSKPSKKIRKKSAQAAQPAVT---VAEQVETVLIETTADNIiqagnNLLIVQSP 278
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1419 ALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQVQALGITP-----TPQPITLTPEQAQALGITPTPQPITLTPEQA 1493
Cdd:cd22540 279 GTGQPAVLQQVQVLQPKQEQQVVQIPQQALRVVQAASATLPTVPqkplqNIQIQNSEPTPTQVYIKTPSGEVQTVLLQEA 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1494 QALGITPTPQPITLTPEQTQALGiTPTPQPITLTPEQAQALGITPTPQPITLTPELVQALGITPTPQPITLTPEQAQALG 1573
Cdd:cd22540 359 PAATATPSSSTSTVQQQVTANNG-TGTSKPNYNVRKERTLPKIAPAGGIISLNAAQLAAAAQAIQTININGVQVQGVPVT 437
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1907114278 1574 ITPTPQPTTLSPEQAQALGIT---PTPQPITLTPEQAQALGITPT 1615
Cdd:cd22540 438 ITNAGGQQQLTVQTVSSNNLTisgLSPTQIQLQMEQALEIETQPG 482
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1319-1661 |
5.07e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.08 E-value: 5.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1319 PEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEqaqALGITPTPQPIT----LTPEQAQALGITPTPQPITLT 1394
Cdd:PHA03247 2484 AEARFPFAAGAAPDPGGGGPPDPDAPPAPSRLAPAILPDE---PVGEPVHPRMLTwirgLEELASDDAGDPPPPLPPAAP 2560
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1395 PeqAQALGITPTPQPITLTPE-QTQALGITPTPQPITLTPeqaQALGITPTPQPITLTPEQVQALGITPTPQPITLTPEQ 1473
Cdd:PHA03247 2561 P--AAPDRSVPPPRPAPRPSEpAVTSRARRPDAPPQSARP---RAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAA 2635
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1474 AQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGIT-PTPQPITLTPELVQA 1552
Cdd:PHA03247 2636 NEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAdPPPPPPTPEPAPHAL 2715
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1553 LGITPTPQPITLTPEQAQALGITPTPQPTTLSPeqaqALGITPTPQPITLTPeqAQALGITPTPQPTTLSPEQAQALGIS 1632
Cdd:PHA03247 2716 VSATPLPPGPAAARQASPALPAAPAPPAVPAGP----ATPGGPARPARPPTT--AGPPAPAPPAAPAAGPPRRLTRPAVA 2789
|
330 340
....*....|....*....|....*....
gi 1907114278 1633 LIPKQQEISLSPEQAQALGLTLTPQQAQV 1661
Cdd:PHA03247 2790 SLSESRESLPSPWDPADPPAAVLAPAAAL 2818
|
|
| MRS6 |
COG5043 |
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion]; |
25-255 |
5.55e-04 |
|
Vacuolar protein sorting-associated protein [Intracellular trafficking and secretion];
Pssm-ID: 227376 [Multi-domain] Cd Length: 2552 Bit Score: 46.03 E-value: 5.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 25 LATLRKPISNRDNPL-SLQFEIPASV---QSVIHKIEESHIFRAKEEVIWRLTEIMSNVELIMTRYNIDS---MSPGRKG 97
Cdd:COG5043 47 LDKLGLPIEVTSGLIgTLTLEIPWSSlknKPVEIYIEDIYLLISPQAKNSLTREELPQSQQALKQRQLDSweiLRETLEE 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 98 SSSESQKKKRKAFLEKIATVMT--------NVDLR-ERTLSKILSWLEEWNLILSEVSAINMDDyyHWT-----VKMELI 163
Cdd:COG5043 127 SSSSPNISRKQSFIESLITKLIdniqiyieDIHLRfEDNLSADLEGPYSFGLTLYSLRATSTDA--SWTeyfvsTDSSCI 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 164 -------------PDTLKRISK-NVDSLIQMALLLVEEKKRAKKR-ILA--RGTLWkawkdRAIKRPATAQALRLD-QMI 225
Cdd:COG5043 205 hklitldyfsiywCEISPCITTeDIDSYLENFQPMIAEKSPAYNEyILKpvRGTAK-----VSINKLPTDEIPRLRgQLS 279
|
250 260 270
....*....|....*....|....*....|....*.
gi 1907114278 226 FDQIGL---NAKVSEIQGMLQEL---IGTAMFSKLE 255
Cdd:COG5043 280 VEEFSIslsDHMYYSLLGVLDYLqvvMKQQKFLKYR 315
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
2312-2742 |
8.17e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.31 E-value: 8.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2312 SPLTPKQPQAVEPAKAKL-----PPLTPSQAQPLQKQLAPELTQTLLFTITLQKAQHLGVTFTYEQTQAAAVTLTSEQVA 2386
Cdd:PHA03247 2678 SPPQRPRRRAARPTVGSLtsladPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARP 2757
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2387 ALEDALTENLAwrweiSVTPGMAQEAPNITTTKQLQALGITARQPAQAFPSPFTLEKPATLATSTDRLSQRWKDSYPASI 2466
Cdd:PHA03247 2758 ARPPTTAGPPA-----PAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT 2832
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2467 PLQALRPSPTQAPFTPTTSLGiGSLLDSEKPWMSPTYRQTltdrgqdvLAQPLAPETPPSLRqllapgaPPTPGPPLGPR 2546
Cdd:PHA03247 2833 SAQPTAPPPPPGPPPPSLPLG-GSVAPGGDVRRRPPSRSP--------AAKPAAPARPPVRR-------LARPAVSRSTE 2896
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2547 HFFKPRVPPTSGEVPGLVSGGSAAHEELPMSRTTPLQPPEWQGPSRLIPEQGFMPAISSIPLHPFTAEALPTPGR----- 2621
Cdd:PHA03247 2897 SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRvavpr 2976
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2622 -------PQRSSKAKPLKPKSARGLPNVT-----LGFETSQAPFPIEKTQIPKTPDTSEQTQAlqdalgvqpfgifqpyg 2689
Cdd:PHA03247 2977 frvpqpaPSREAPASSTPPLTGHSLSRVSswassLALHEETDPPPVSLKQTLWPPDDTEDSDA----------------- 3039
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|...
gi 1907114278 2690 tsSGIARSQSPLIDEKALSREKPGTPLPSLTTQLPQTPQISTSEKGQKPWLPP 2742
Cdd:PHA03247 3040 --DSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGPP 3090
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
2575-2772 |
8.98e-04 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 45.07 E-value: 8.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2575 PMSRTTPLQPPEWQGPSRL-IPEQGFMPAISSIPLHPFTAEALPTPGRPQRSSKAKPLKP-------------------- 2633
Cdd:PTZ00449 600 PRSAQRPTRPKSPKLPELLdIPKSPKRPESPKSPKRPPPPQRPSSPERPEGPKIIKSPKPpkspkppfdpkfkekfyddy 679
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 2634 --KSARGLPNVTlGFETSQAPFPIEKTQIPKTPDTSEQT-QALQDALGVQPFGIFQPYGTSSGIARSQS----PLIDEKA 2706
Cdd:PTZ00449 680 ldAAAKSKETKT-TVVLDESFESILKETLPETPGTPFTTpRPLPPKLPRDEEFPFEPIGDPDAEQPDDIefftPPEEERT 758
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1907114278 2707 LSREKPG-TPLPSLTTQLPQTPQIsTSEKGQKPwlPPIDKPWTPTPVSSTREAKMIVSPTDQHPEDG 2772
Cdd:PTZ00449 759 FFHETPAdTPLPDILAEEFKEEDI-HAETGEPD--EAMKRPDSPSEHEDKPPGDHPSLPKKRHRLDG 822
|
|
| PRK14948 |
PRK14948 |
DNA polymerase III subunit gamma/tau; |
1268-1505 |
1.80e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237862 [Multi-domain] Cd Length: 620 Bit Score: 43.80 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1268 LGITPTPQPitltPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGIT 1347
Cdd:PRK14948 357 LGLLPSAFI----SEIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPTPPANA 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1348 PTPQPITLTPEQAQA-LGITPTPQPITLTPEQAQALGITPTPQPITLTP-------------EQA--QALGitptpQPIT 1411
Cdd:PRK14948 433 ANAPPSLNLEELWQQiLAKLELPSTRMLLSQQAELVSLDSNRAVIAVSPnwlgmvqsrkpllEQAfaKVLG-----RSIK 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1412 LTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPeqvqALGITPTPQPITLTPEQAQALGITPTPQPITLTPE 1491
Cdd:PRK14948 508 LNLESQSGSASNTAKTPPPPQKSPPPPAPTPPLPQPTATAP----PPTPPPPPPTATQASSNAPAQIPADSSPPPPIPEE 583
|
250
....*....|....
gi 1907114278 1492 QAQALGITPTPQPI 1505
Cdd:PRK14948 584 PTPSPTKDSSPEEI 597
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
1172-1582 |
1.96e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 43.75 E-value: 1.96e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1172 ALGITPTPQLITLTPEQAkalanTLTAEQVSLSpqqaealgitptpqPTTLTPEQAQALGITPTPQPITLTPEQAQALGI 1251
Cdd:pfam05109 395 GLGTAPKTLIITRTATNA-----TTTTHKVIFS--------------KAPESTTTSPTLNTTGFAAPNTTTGLPSSTHVP 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1252 TPTPQPTTLTPEQTQALGITPTPQPITltpeqAQALGITPTPQPI-----TLTPEQTQALGITPTPQPITLTPEQAQAlg 1326
Cdd:pfam05109 456 TNLTAPASTGPTVSTADVTSPTPAGTT-----SGASPVTPSPSPRdngteSKAPDMTSPTSAVTTPTPNATSPTPAVT-- 528
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1327 iTPTPQPITLTPEQTQALGITPTPQPITLTPEQAQAlgiTPTPQPITLTPEQAQALGITPTPQPITLTPEQAQAlgitpT 1406
Cdd:pfam05109 529 -TPTPNATSPTLGKTSPTSAVTTPTPNATSPTPAVT---TPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGET-----S 599
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1407 PQPITltpeQTQALGITPTPQPITLTPEQAQAlgiTPTPQPITLTPEQVQALGITPTPQPITLTPEQAQAlgiTPTPQPI 1486
Cdd:pfam05109 600 PQANT----TNHTLGGTSSTPVVTSPPKNATS---AVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDN---STSHMPL 669
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1487 TLTPEQAQALGITptpqpiTLTPEQTQALGI-TPTPQPITLTPEQAQALGITPTpqpiTLTPELVQALGITPtpqPITLT 1565
Cdd:pfam05109 670 LTSAHPTGGENIT------QVTPASTSTHHVsTSSPAPRPGTTSQASGPGNSST----STKPGEVNVTKGTP---PKNAT 736
|
410
....*....|....*..
gi 1907114278 1566 PEQAQALGITPTPQPTT 1582
Cdd:pfam05109 737 SPQAPSGQKTAVPTVTS 753
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
1073-1493 |
2.41e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.60 E-value: 2.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1073 GLPLIPPKPITFTreqTQALGITPTHQPITLTSEqvqalGITPTHQPITLTPEQAQALALILTTEQVKTQRInlsPDQTQ 1152
Cdd:pfam03154 179 GAASPPSPPPPGT---TQAATAGPTPSAPSVPPQ-----GSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRL---PSPHP 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1153 ALGITPTPQPITFTPEQTqalgiTPTPQLITLTPEQAKALANTLTAEQVSLSPQqaealgitptPQPTTLTPEQAQalgI 1232
Cdd:pfam03154 248 PLQPMTQPPPPSQVSPQP-----LPQPSLHGQMPPMPHSLQTGPSHMQHPVPPQ----------PFPLTPQSSQSQ---V 309
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1233 TPTPQPITLTPEQAQALGITPTPQPTTLTPEQTQALGITPTPQPiTLTPEQAQALGITPTPQPITLTPEQTqalGITPTP 1312
Cdd:pfam03154 310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMP-HIKPPPTTPIPQLPNPQSHKHPPHLS---GPSPFQ 385
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1313 QPITLTPEQA-QALGITPTPQPITLTPEQTQALgitptPQPITLTPEQAQALGITPTPqpiTLTPEQAQAlgitPTPQPI 1391
Cdd:pfam03154 386 MNSNLPPPPAlKPLSSLSTHHPPSAHPPPLQLM-----PQSQQLPPPPAQPPVLTQSQ---SLPPPAASH----PPTSGL 453
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1392 TLTPEQ---AQALGITPTPQPIT--LTPEQTQALGITPTPQPITLTPEQAQALGITPTpqpITLTPEQVQALGITPTPQP 1466
Cdd:pfam03154 454 HQVPSQspfPQHPFVPGGPPPITppSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVS---CPLPPVQIKEEALDEAEEP 530
|
410 420
....*....|....*....|....*...
gi 1907114278 1467 ITLTPEQAqalgiTPTPQP-ITLTPEQA 1493
Cdd:pfam03154 531 ESPPPPPR-----SPSPEPtVVNTPSHA 553
|
|
| PRK14948 |
PRK14948 |
DNA polymerase III subunit gamma/tau; |
1263-1486 |
2.78e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237862 [Multi-domain] Cd Length: 620 Bit Score: 43.41 E-value: 2.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1263 EQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQTQ 1342
Cdd:PRK14948 367 EIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPTPPANAANAPPSLNLEELWQ 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1343 A-LGITPTPQPITLTPEQAQALGITPTPQPITLTP-------------EQA--QALGitptpQPITLTPEQAQALGITPT 1406
Cdd:PRK14948 447 QiLAKLELPSTRMLLSQQAELVSLDSNRAVIAVSPnwlgmvqsrkpllEQAfaKVLG-----RSIKLNLESQSGSASNTA 521
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1407 PQPITLTPEQTQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQVQAlgitPTPQPITLTPEQAQALGITPTPQPI 1486
Cdd:PRK14948 522 KTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPPPPPTATQASSNAPAQIPA----DSSPPPPIPEEPTPSPTKDSSPEEI 597
|
|
| PRK14948 |
PRK14948 |
DNA polymerase III subunit gamma/tau; |
1420-1646 |
6.60e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237862 [Multi-domain] Cd Length: 620 Bit Score: 41.87 E-value: 6.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1420 LGITPTPQPitltPEQAQALGITPTPQPITLTPEQVQALGITPTPQPITLTPEQAQALGITPTPQPITLTPEQAQALGIT 1499
Cdd:PRK14948 357 LGLLPSAFI----SEIANASAPANPTPAPNPSPPPAPIQPSAPKTKQAATTPSPPPAKASPPIPVPAEPTEPSPTPPANA 432
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1500 PTPQPITLTPEQTQA-LGITPTPQPITLTPEQAQALGITPTPQPITLTPELV---------------QALGitptpQPIT 1563
Cdd:PRK14948 433 ANAPPSLNLEELWQQiLAKLELPSTRMLLSQQAELVSLDSNRAVIAVSPNWLgmvqsrkplleqafaKVLG-----RSIK 507
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907114278 1564 LTPEQAQALGITPTPQPTTLSPEQAQALGITPTPQPITLTPEQAQALGITPTPQPTTLSPEQAQALGISLIPKQQEISLS 1643
Cdd:PRK14948 508 LNLESQSGSASNTAKTPPPPQKSPPPPAPTPPLPQPTATAPPPTPPPPPPTATQASSNAPAQIPADSSPPPPIPEEPTPS 587
|
...
gi 1907114278 1644 PEQ 1646
Cdd:PRK14948 588 PTK 590
|
|
| |
